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Letter to the editor: "Evaluation of bromocriptine for the reduction of fever in patients with acute neurologic injury: A retrospective cohort study". 致编辑的信:“评价溴隐亭对急性神经损伤患者退烧的作用:一项回顾性队列研究”。
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-02-01 Epub Date: 2025-10-29 DOI: 10.1016/j.jcrc.2025.155331
Shyam Sundar Sah, Abhishek Kumbhalwar
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引用次数: 0
Letter to the editor: Effect of music intervention on anxiety in critically ill patients, a meta-analysis of randomized controlled trials. 给编辑的信:音乐干预对危重病人焦虑的影响,随机对照试验的荟萃分析。
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-02-01 Epub Date: 2025-10-27 DOI: 10.1016/j.jcrc.2025.155322
Abdullahٰ Aljasar
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引用次数: 0
Mixed methods evaluation of a digital tool to support the transfer of medication information from ICU to ward. 支持从ICU到病房的药物信息传递的数字工具的混合方法评估。
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-02-01 Epub Date: 2025-08-07 DOI: 10.1016/j.jcrc.2025.155219
Melissa T Baysari, Kristian Stanceski, Bethany A Van Dort, Jacques Raubenheimer, Lily Pham, Danielle Deidun, Adeola Bamgboje-Ayodele, Duncan Mackay, Jonathan Penm, Kevin Sam, Selvana Awad, Gordon Flynn, Atul Gaur, Stuart Lane

Background: Transfer of medication information from intensive care units (ICUs) to general wards is error prone. Additional challenges emerge in hospitals where a different electronic medical record (eMR) is used in ICU and wards. Digital transfer systems, that support information transfer between different eMRs, could minimise errors, but limited research has evaluated these. We aimed to 1) determine the impact of eTOC, a medication transfer system, on medication errors and potential patient harms that occur during ICU-to-ward transfers, 2) to determine frequency of eTOC use post-implementation, and 3) explore how eTOC is used and viewed by clinicians.

Methods: A mixed methods approach was used at one metropolitan and one regional hospital in NSW, Australia. Part 1 comprised a pragmatic pre-post chart-review study (n = 200 patient transfers) and Part 2 used a qualitative approach, including usability testing (n = 4) and semi-structured interviews with clinicians (n = 11).

Results: Implementation of the eTOC system did not significantly reduce the number of transfers containing an error (51 % vs 46 %, pre-post). Although the use of eTOC more than halved the odds of a medication error occurring (OR: 0.44, 95 %CI: 0.27-0.71), the system was inconsistently used. Interviews and usability testing revealed that barriers related both to system design/configuration and to the context of use and organisation (e.g., time pressure) impacted uptake of eTOC.

Conclusions: There is significant potential for technology to support transfer of medication information from ICU to the ward and improve safety if technology is designed well and aligns with how work is done in practice.

背景:从重症监护病房(icu)到普通病房的药物信息传递容易出错。在ICU和病房使用不同电子医疗记录(eMR)的医院中出现了其他挑战。支持不同电子病历之间信息传递的数字传输系统可以最大限度地减少错误,但对这些系统进行评估的研究有限。我们的目的是1)确定eTOC(一种药物转移系统)对在icu到病房转移过程中发生的药物错误和潜在患者伤害的影响,2)确定实施后使用eTOC的频率,以及3)探索临床医生如何使用和看待eTOC。方法:在澳大利亚新南威尔士州的一家城市医院和一家地区医院采用混合方法。第一部分包括一项实用的前后图表回顾研究(n = 200例患者转移),第二部分使用定性方法,包括可用性测试(n = 4)和与临床医生的半结构化访谈(n = 11)。结果:eTOC系统的实施并没有显著减少包含错误的转移次数(51%对46%,post前)。虽然使用eTOC使用药错误发生的几率减少了一半以上(OR: 0.44, 95% CI: 0.27-0.71),但该系统的使用并不一致。访谈和可用性测试显示,与系统设计/配置以及使用和组织背景(例如,时间压力)相关的障碍影响了eTOC的吸收。结论:如果技术设计良好并与实际工作相一致,那么技术支持将药物信息从ICU转移到病房并提高安全性的潜力很大。
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引用次数: 0
Letter to the editor: "Different microcirculatory patterns in patients with COVID-19 and non-COVID-19 ARDS: A multicenter cross-sectional study". 致编辑的信:“COVID-19和非COVID-19 ARDS患者的不同微循环模式:一项多中心横断面研究”。
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-01-31 DOI: 10.1016/j.jcrc.2026.155455
Fengyu Chen, Chunming Zhang, Kan Kan, Zejun Xue, Jun Zhang
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引用次数: 0
Between a nightmare and a miracle: A qualitative study of patient experience during and after intensive care unit admission in pregnancy or postpartum. 在噩梦和奇迹之间:在怀孕或产后重症监护病房住院期间和之后的患者体验的定性研究。
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-01-31 DOI: 10.1016/j.jcrc.2026.155472
Yarden Zerem, Sharon Einav, Carolyn F Weiniger, Reut Schvartz, Hen Y Sela, Adi Finkelstein

Background: Intensive care unit (ICU) admission of obstetric patients during pregnancy or postpartum is not uncommon. The long-term physical and emotional implications of such admissions require elucidation.

Aim: To describe obstetric patients' long-term perspectives on ICU admission and recovery.

Methods: A phenomenological approach was undertaken. All consecutive obstetric patients admitted to the ICU during 2016-2021 were invited to participate in a semi-structured interview after hospital discharge. Interviews were conducted from 12/2020 to 06/2022, and the transcripts were analyzed using Braun and Clarke's six-phase approach to reflexive thematic analysis.

Results: A total of 59 women aged 20-34 years admitted to an ICU during pregnancy or postpartum were interviewed. Qualitative inductive analysis of the interview transcripts generated three themes: the illness experience, an atypical patient, and recovery. Repetitive topics were a sense of disorientation, feeling distressed and scared, the importance of remaining in contact with and informed on the neonate, the importance of partner and family support, the challenges of being an atypical ICU patient, the difficulties in returning to normal life, and coping strategies.

Conclusions: This study sheds new light on the experiences of obstetric patients admitted to an ICU. It highlights missed opportunities for maternal‑neonatal bonding, the importance of family support, unique needs that often remain unmet, the need for effective communication with the ICU staff, and the physical and emotional long-term adverse effects of the experience. The patient's narrative can contribute to our understanding of the ICU experience as a whole and its outcomes.

背景:产科患者在妊娠期或产后入住重症监护病房(ICU)并不罕见。这种承认对身体和情感的长期影响需要澄清。目的:探讨产科患者对ICU住院和康复的长期看法。方法:采用现象学方法。所有2016-2021年期间连续入住ICU的产科患者在出院后被邀请参加半结构化访谈。访谈时间为2020年12月至2022年6月,访谈记录采用Braun和Clarke的反思性主题分析六阶段法进行分析。结果:对59名孕期或产后入住ICU的20 ~ 34岁女性进行了访谈。访谈记录的定性归纳分析产生了三个主题:疾病经历,非典型患者和康复。重复的话题包括迷失方向、感到痛苦和害怕、与新生儿保持联系和了解新生儿情况的重要性、伴侣和家庭支持的重要性、作为一名非典型ICU患者的挑战、回归正常生活的困难以及应对策略。结论:本研究揭示了新的经验,产科患者入住ICU。它强调了错失的孕产妇与新生儿建立联系的机会、家庭支持的重要性、经常未得到满足的独特需求、与ICU工作人员进行有效沟通的需要,以及这种经历对身体和情感的长期不利影响。患者的叙述有助于我们对ICU的整体经验及其结果的理解。
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引用次数: 0
Subphenotypes in acute respiratory distress syndrome: A scoping review across clinical, biological, computational, imaging, omics, and artificial intelligence approaches 急性呼吸窘迫综合征的亚表型:临床、生物学、计算、成像、组学和人工智能方法的范围综述
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-01-30 DOI: 10.1016/j.jcrc.2026.155441
Javier Muñoz , Jamil Antonio Cedeño , Galo Francisco Castañeda

Background

Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome with high mortality. Subphenotyping may identify more homogeneous groups for prognostic enrichment and precision therapies.

Methods

We conducted a scoping review (January 2013–December 31, 2025) in PubMed, Embase, and the Cochrane Library, complemented by reference screening. We included original adult studies deriving, applying, or validating ARDS phenotypes/subphenotypes and excluded pediatric, preclinical, review/editorial, and abstract-only reports.

Results

Sixty studies met eligibility criteria. Subphenotypes were reported across clinical, biological, computational, imaging, omics, and artificial intelligence (AI) domains, with uneven evidence maturity; reproducibility and validation were strongest in biological and computational frameworks, whereas imaging and omics evidence was more heterogeneous and less frequently externally validated. The most robust distinction separated hyperinflammatory and hypoinflammatory groups, differing in mortality, ventilator-free days, and organ failure, and showing heterogeneity of treatment effect in secondary analyses of randomized trials (fluid management, statins, corticosteroids, and recruitment manoeuvres). Clinical and computational approaches provided parsimonious classifiers for near real-time assignment, while biological studies implicated inflammatory, epithelial, and endothelial injury markers. AI models integrated multimodal data and reproduced known phenotypes, but external validation and interpretability were inconsistent.

Conclusions

ARDS subphenotypes—particularly hyperinflammatory and hypoinflammatory classes—are prognostically meaningful and associated with heterogeneity of treatment effect. Parsimonious clinical and computational classifiers appear closest to bedside translation. Future research should prioritise prospective phenotype-stratified/adaptive trials using standardized, transparent algorithms in diverse international cohorts.
背景:急性呼吸窘迫综合征(ARDS)是一种高死亡率的异质性综合征。亚表型可以确定更均匀的群体,以进行预后富集和精确治疗。方法我们在PubMed、Embase和Cochrane图书馆进行了范围综述(2013年1月- 2025年12月31日),并辅以参考文献筛选。我们纳入了衍生、应用或验证ARDS表型/亚表型的原始成人研究,排除了儿科、临床前、综述/编辑和仅限摘要的报告。结果60项研究符合入选标准。亚表型报告涉及临床、生物学、计算、成像、组学和人工智能(AI)领域,证据成熟度不均匀;在生物学和计算框架中,可重复性和验证性最强,而成像和组学证据则更加异构,外部验证的频率更低。最明显的区别是将高炎症组和低炎症组分开,在死亡率、无呼吸机天数和器官衰竭方面存在差异,并且在随机试验的二次分析中显示治疗效果的异质性(液体管理、他汀类药物、皮质类固醇和招募操作)。临床和计算方法为近实时分配提供了简约的分类器,而生物学研究涉及炎症、上皮和内皮损伤标志物。人工智能模型集成了多模态数据并再现了已知的表型,但外部验证和可解释性不一致。结论ards亚表型,特别是高炎性和低炎性亚型,具有预后意义,且与治疗效果的异质性相关。简约的临床分类器和计算分类器似乎最接近床边翻译。未来的研究应优先考虑前瞻性表型分层/适应性试验,在不同的国际队列中使用标准化、透明的算法。
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引用次数: 0
Sex differences in venoarterial extracorporeal membrane oxygenation utilisation and clinical outcomes in Australia 澳大利亚静脉动脉体外膜氧合使用和临床结果的性别差异
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-01-29 DOI: 10.1016/j.jcrc.2026.155473
Riley J. Batchelor , Carol L. Hodgson , Malanka Lankaputhra , Aidan Burrell , Judit Orosz , Julia Coull , Vincent Pellegrino , James Antsey , Jeffrey Lefkovits , Andrew J. Taylor , David M. Kaye , Dion Stub , on behalf of EXCEL coinvestigators

Background

Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly utilised in critically ill patients with severe cardiac failure and cardiac arrest, yet sex-specific differences in presentation, utilisation, and clinical outcomes are not well understood.

Methods

The EXCEL registry is a binational registry capturing data on patients requiring ECMO in Australia and New Zealand. Data were collected on adult patients supported with VA-ECMO in Australia from February 2019 to December 2024. Patients were stratified by sex to assess differences in demographics, clinical characteristics, ECMO indications, complications, and outcomes. Multivariable logistic regression analyses conditional on several baseline covariates assessed associations between sex, in-hospital mortality, and major bleeding.

Results

Among 1443 patients undergoing VA-ECMO, 32.7% female and 67.3% were male. Females were younger, had lower APACHE IV scores, and more commonly required ECMO for myocarditis, pulmonary embolism, and advanced pulmonary hypertension. Conversely, males predominantly presented with acute myocardial infarction and more frequently had cardiac arrest with a shockable rhythm. Unadjusted in-hospital mortality was comparable between sexes; however, following adjustment, female sex independently predicted higher in-hospital mortality (OR 1.41, 95% CI 1.07–1.87; p = 0.015) and major bleeding (OR 1.40, 95% CI 1.03–1.91; p = 0.033).

Conclusion

Female patients represent one third of the VA-ECMO population and are a distinct cohort to male patients. Despite younger age and fewer traditional risk factors, female sex is associated with increased adjusted risk of in-hospital mortality and bleeding in VA-ECMO patients. These findings should be interpreted as an adjusted association that is contingent on the completeness of covariate adjustment.
背景静脉体外膜氧合(VA-ECMO)越来越多地用于严重心力衰竭和心脏骤停的危重患者,但在表现、使用和临床结果方面的性别差异尚不清楚。方法EXCEL注册表是一个两国注册表,收集澳大利亚和新西兰需要ECMO的患者的数据。收集了2019年2月至2024年12月在澳大利亚接受VA-ECMO支持的成年患者的数据。患者按性别分层,以评估人口统计学、临床特征、ECMO指征、并发症和结果的差异。以几个基线协变量为条件的多变量logistic回归分析评估了性别、住院死亡率和大出血之间的关系。结果1443例VA-ECMO患者中,女性32.7%,男性67.3%。女性更年轻,APACHE IV评分更低,心肌炎、肺栓塞和晚期肺动脉高压更常需要ECMO。相反,男性主要表现为急性心肌梗死,更常见的是心脏骤停伴有震荡性心律。未经调整的住院死亡率在性别之间具有可比性;然而,调整后,女性独立预测更高的住院死亡率(OR 1.41, 95% CI 1.07-1.87; p = 0.015)和大出血(OR 1.40, 95% CI 1.03-1.91; p = 0.033)。结论女性患者占VA-ECMO患者总数的三分之一,与男性患者相比是一个明显的队列。尽管年龄较小,传统风险因素较少,但女性与VA-ECMO患者住院死亡率和出血调整风险增加有关。这些发现应该被解释为一个调整后的关联,这取决于协变量调整的完整性。
{"title":"Sex differences in venoarterial extracorporeal membrane oxygenation utilisation and clinical outcomes in Australia","authors":"Riley J. Batchelor ,&nbsp;Carol L. Hodgson ,&nbsp;Malanka Lankaputhra ,&nbsp;Aidan Burrell ,&nbsp;Judit Orosz ,&nbsp;Julia Coull ,&nbsp;Vincent Pellegrino ,&nbsp;James Antsey ,&nbsp;Jeffrey Lefkovits ,&nbsp;Andrew J. Taylor ,&nbsp;David M. Kaye ,&nbsp;Dion Stub ,&nbsp;on behalf of EXCEL coinvestigators","doi":"10.1016/j.jcrc.2026.155473","DOIUrl":"10.1016/j.jcrc.2026.155473","url":null,"abstract":"<div><h3>Background</h3><div>Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly utilised in critically ill patients with severe cardiac failure and cardiac arrest, yet sex-specific differences in presentation, utilisation, and clinical outcomes are not well understood.</div></div><div><h3>Methods</h3><div>The EXCEL registry is a binational registry capturing data on patients requiring ECMO in Australia and New Zealand. Data were collected on adult patients supported with VA-ECMO in Australia from February 2019 to December 2024. Patients were stratified by sex to assess differences in demographics, clinical characteristics, ECMO indications, complications, and outcomes. Multivariable logistic regression analyses conditional on several baseline covariates assessed associations between sex, in-hospital mortality, and major bleeding.</div></div><div><h3>Results</h3><div>Among 1443 patients undergoing VA-ECMO, 32.7% female and 67.3% were male. Females were younger, had lower APACHE IV scores, and more commonly required ECMO for myocarditis, pulmonary embolism, and advanced pulmonary hypertension. Conversely, males predominantly presented with acute myocardial infarction and more frequently had cardiac arrest with a shockable rhythm. Unadjusted in-hospital mortality was comparable between sexes; however, following adjustment, female sex independently predicted higher in-hospital mortality (OR 1.41, 95% CI 1.07–1.87; <em>p</em> = 0.015) and major bleeding (OR 1.40, 95% CI 1.03–1.91; <em>p</em> = 0.033).</div></div><div><h3>Conclusion</h3><div>Female patients represent one third of the VA-ECMO population and are a distinct cohort to male patients. Despite younger age and fewer traditional risk factors, female sex is associated with increased adjusted risk of in-hospital mortality and bleeding in VA-ECMO patients. These findings should be interpreted as an adjusted association that is contingent on the completeness of covariate adjustment.</div></div>","PeriodicalId":15451,"journal":{"name":"Journal of critical care","volume":"93 ","pages":"Article 155473"},"PeriodicalIF":2.9,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: “Recovery of motor functions and cognitive functions in patients with intensive care unit–acquired weakness” 致编辑的信:“重症监护病房获得性虚弱患者运动功能和认知功能的恢复”
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-01-29 DOI: 10.1016/j.jcrc.2026.155477
Sandhya Anil Harihar , Anant Sidhappa Kurhade
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引用次数: 0
Response to the letter: Effects of levosimendan on weaning from mechanical ventilation 回复来信:左西孟旦对机械通气脱机的影响
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-01-29 DOI: 10.1016/j.jcrc.2026.155450
Cang Li, Fei Guo, Zengfeng Wang, Liang Shan
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引用次数: 0
Acute respiratory distress syndrome and acute kidney injury in critically ill patients: A scoping review on this lung-kidney crosstalk 危重病人急性呼吸窘迫综合征和急性肾损伤:肺肾串扰的范围综述
IF 2.9 3区 医学 Q2 CRITICAL CARE MEDICINE Pub Date : 2026-01-27 DOI: 10.1016/j.jcrc.2026.155445
Francisco Z. Mattedi , Heitor S. Ribeiro , Geraldo F. Busatto , Carlos R.R. Carvalho , Dirce Maria Trevisan Zanetta , Emmanuel A. Burdmann , on behalf of the HCFMUSP COVID-19 Study Group

Introduction

The incidence of acute kidney injury (AKI) in patients with acute respiratory distress syndrome (ARDS) is high; nonetheless, the lung-kidney crosstalk remains unclear.

Objective

Describe the association between ARDS and AKI in critically ill patients.

Methods

This scoping review was conducted according to the JBI and PRISM-ScR and included studies that investigated critically ill patients with ARDS (Participants), described AKI-related outcomes (Concept), and were conducted in hospitals (Context). MEDLINE, Embase, and LILACS databases were searched for articles published up to January 2024. Only observational studies were considered. Data on the diagnosis of ARDS-AKI and other kidney-related outcomes were extracted.

Results

A total of 2943 studies were screened, of which 28 were included in this review. Most studies were prospective and the majority originated from Europe. AKI was diagnosed using the KDIGO criteria in most studies and the pooled overall rate of AKI development across the studies was 46.8% (95% CI: 40.8–52.8). Two reports identified ARDS as an independent risk factor for AKI. Kidney replacement therapy was described in 17 studies. AKI recovery was described in only three studies. Seventeen studies evaluated hospital mortality, specifically in patients with ARDS-AKI, and found a greater mortality risk as compared to only ARDS.

Conclusions

This scoping review emphasizes the variability of the evidence, which hinders definitive conclusions about the association between ARDS and AKI, despite their common occurrence in critically ill patients. Therefore, a significant gap remains in our understanding of this lung-kidney interaction.
急性呼吸窘迫综合征(ARDS)患者急性肾损伤(AKI)发生率高;尽管如此,肺肾间的相互作用仍不清楚。目的探讨危重患者急性呼吸窘迫综合征(ARDS)与AKI的关系。方法本综述根据JBI和PRISM-ScR进行,纳入了调查ARDS危重患者(参与者)、描述aki相关结果(概念)和在医院进行的研究(背景)。在MEDLINE、Embase和LILACS数据库中搜索到2024年1月之前发表的文章。只考虑观察性研究。提取ARDS-AKI诊断和其他肾脏相关结局的数据。结果共筛选2943项研究,其中28项纳入本综述。大多数研究是前瞻性的,大多数来自欧洲。在大多数研究中,AKI是使用KDIGO标准诊断的,所有研究中AKI的总发生率为46.8% (95% CI: 40.8-52.8)。两份报告将ARDS确定为AKI的独立危险因素。17项研究描述了肾脏替代疗法。只有三项研究描述了AKI的恢复。17项研究评估了医院死亡率,特别是ARDS- aki患者的死亡率,发现与ARDS患者相比,ARDS患者的死亡率风险更高。结论:本综述强调了证据的可变性,尽管ARDS和AKI在危重患者中常见,但这阻碍了关于ARDS和AKI之间关联的明确结论。因此,我们对这种肺-肾相互作用的理解仍有很大的差距。
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引用次数: 0
期刊
Journal of critical care
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