Pub Date : 2020-06-18DOI: 10.15226/2378-1726/7/3/001116
P. Mawardi, M. Mardiana
Melasma is a hyperpigmented lesion that occurs on different skin areas that are often exposed to sunlight with predilection arising on the face, neck, and partially on arms or other body parts. It is also known as chloasma or black colour. This pigmentation disorder is common to people with IV-VI type of skin, and those living in the environment with more Ultraviolet (UV) exposure. Yet, its etiology has not been understood clearly. The major influential factors on its pathogenesis are UV radiation exposure, endocrine factor, genetic predisposition, the phototoxic/ photoallergies medicine,anticonvulsant medicine,particularly cosmetics, and nutrition deficiency are reportedly less influential or a rare factor. The aim of this research is to prove the difference between melanin index number on melasma patients having therapies by using non-hydoquinone cream and Kligman’s formula.
{"title":"The Difference of Melanin Index in Treatment of MelasmaUsing Non-Hydroquinone Cream and Kligman's Formula","authors":"P. Mawardi, M. Mardiana","doi":"10.15226/2378-1726/7/3/001116","DOIUrl":"https://doi.org/10.15226/2378-1726/7/3/001116","url":null,"abstract":"Melasma is a hyperpigmented lesion that occurs on different skin areas that are often exposed to sunlight with predilection arising on the face, neck, and partially on arms or other body parts. It is also known as chloasma or black colour. This pigmentation disorder is common to people with IV-VI type of skin, and those living in the environment with more Ultraviolet (UV) exposure. Yet, its etiology has not been understood clearly. The major influential factors on its pathogenesis are UV radiation exposure, endocrine factor, genetic predisposition, the phototoxic/ photoallergies medicine,anticonvulsant medicine,particularly cosmetics, and nutrition deficiency are reportedly less influential or a rare factor. The aim of this research is to prove the difference between melanin index number on melasma patients having therapies by using non-hydoquinone cream and Kligman’s formula.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73463361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-25DOI: 10.15226/2378-1726/7/2/001113
G. Amorim, Eduardo Dan Itaya, Gabriela Coelho Itaya, Luiza Mousquer Leal, Amanda Amaro Pereira, Roberto Moreira Amorim Filho
We present a case of a 50 year-old woman with multiple erythematous and hyperpigmented plaques, with achromic and slightly atrophic centers, restricted to a body segment. Dermoscopy showed a pigmented network surrounding a central scar-like patch. Histopathology, complemented by immunohistochemical profile was compatible with dermatofibromas, arranged in a multiple clustered form. Relevant literature on the topic was reviewed. Meshterms: Factor 13a Positivity; Benign Fibrous Histiocytoma; Multiple clustered dermatofibroma; Segmental Distribution
{"title":"Multiple Clustered and Focally Atrophic Dermatofibromas: Case Report and Literature Review","authors":"G. Amorim, Eduardo Dan Itaya, Gabriela Coelho Itaya, Luiza Mousquer Leal, Amanda Amaro Pereira, Roberto Moreira Amorim Filho","doi":"10.15226/2378-1726/7/2/001113","DOIUrl":"https://doi.org/10.15226/2378-1726/7/2/001113","url":null,"abstract":"We present a case of a 50 year-old woman with multiple erythematous and hyperpigmented plaques, with achromic and slightly atrophic centers, restricted to a body segment. Dermoscopy showed a pigmented network surrounding a central scar-like patch. Histopathology, complemented by immunohistochemical profile was compatible with dermatofibromas, arranged in a multiple clustered form. Relevant literature on the topic was reviewed. Meshterms: Factor 13a Positivity; Benign Fibrous Histiocytoma; Multiple clustered dermatofibroma; Segmental Distribution","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90524409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-26DOI: 10.15226/2378-1726/7/1/001109
H. Hur, Duck Taik Shim, S. Song, Pyoung-Su Kim, Dong-Nyeok Hyun, Yu Ri Kim
Background: Infantile Café-Au-Lait Spot (CALS) is a benign hyperpigmentary skin disorder that ranges in color from light brown to dark brown. Using traditional laser therapies including 532nm potassium titanyl phosphate(KTP) laser, 694nm ruby laser and 755nm alexandrite laser for infantile CALS treatment may provoke harmful side effects such as purpurae, crusts,Post-Inflammatory Hyperpigmentation (PIH), mottled hypopigmentation and scarring. Unfortunately, there is no clear standard for the laser treatment of infantile CALS because an infant is too young to receive laser treatment. Objectives: This study was performed to investigate the efficacy and safety of Dr. Hoon Hur’s Golden Parameter Therapy (GPT) with a high fluence 1064nm Q-switched Nd:YAG laser laser (QSNL) for infantile CALS treatment. Methods: Nineteen Korean patients with infantile CALS were enrolled in this study and treated with a 1064nm QSNL on a weekly basis for 20-50 treatment sessions of Dr. Hoon Hur’s GPT. The parameters were a spot size of 7 mm, a fluence of 2.2 J/cm2 and a pulse rate of 10Hz with one pass by a sliding-stacking technique over the infantile CALS. Results: After the final treatment, all of the 19 patients with infantile CALS were achieved the complete removal of pigmented lesions without any side effects such as purpurae, crusts, PIH, mottled hypopigmentation or scarring. No recurrences were observed in any of the patients after a follow- up of 6-14 months. Conclusion: We suggest that Dr. Hoon Hur’s GPT with a high fluence 1064nm QSNL is a safe and effective treatment for infantile CALS without causing side effects and recurrences. Keywords: Infantile Cafe au Lait Spot; 1064nm Nd:YAG laser; Dr. Hoon Hur’s GPT
{"title":"The Treatment of Infantile Cafe Au Lait Spot Using Dr. Hoon Hur’s Golden Parameter Therapy with a High Fluence 1064nm Q-Switched Nd: Yag Laser","authors":"H. Hur, Duck Taik Shim, S. Song, Pyoung-Su Kim, Dong-Nyeok Hyun, Yu Ri Kim","doi":"10.15226/2378-1726/7/1/001109","DOIUrl":"https://doi.org/10.15226/2378-1726/7/1/001109","url":null,"abstract":"Background: Infantile Café-Au-Lait Spot (CALS) is a benign hyperpigmentary skin disorder that ranges in color from light brown to dark brown. Using traditional laser therapies including 532nm potassium titanyl phosphate(KTP) laser, 694nm ruby laser and 755nm alexandrite laser for infantile CALS treatment may provoke harmful side effects such as purpurae, crusts,Post-Inflammatory Hyperpigmentation (PIH), mottled hypopigmentation and scarring. Unfortunately, there is no clear standard for the laser treatment of infantile CALS because an infant is too young to receive laser treatment. Objectives: This study was performed to investigate the efficacy and safety of Dr. Hoon Hur’s Golden Parameter Therapy (GPT) with a high fluence 1064nm Q-switched Nd:YAG laser laser (QSNL) for infantile CALS treatment. Methods: Nineteen Korean patients with infantile CALS were enrolled in this study and treated with a 1064nm QSNL on a weekly basis for 20-50 treatment sessions of Dr. Hoon Hur’s GPT. The parameters were a spot size of 7 mm, a fluence of 2.2 J/cm2 and a pulse rate of 10Hz with one pass by a sliding-stacking technique over the infantile CALS. Results: After the final treatment, all of the 19 patients with infantile CALS were achieved the complete removal of pigmented lesions without any side effects such as purpurae, crusts, PIH, mottled hypopigmentation or scarring. No recurrences were observed in any of the patients after a follow- up of 6-14 months. Conclusion: We suggest that Dr. Hoon Hur’s GPT with a high fluence 1064nm QSNL is a safe and effective treatment for infantile CALS without causing side effects and recurrences. Keywords: Infantile Cafe au Lait Spot; 1064nm Nd:YAG laser; Dr. Hoon Hur’s GPT","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80302678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-30DOI: 10.15226/2378-1726/6/5/001103
I. Temelkova, G. Tchernev
{"title":"Tinea Imbricate- like Pemphigus erythematosus (Senear-Usher syndrome)!","authors":"I. Temelkova, G. Tchernev","doi":"10.15226/2378-1726/6/5/001103","DOIUrl":"https://doi.org/10.15226/2378-1726/6/5/001103","url":null,"abstract":"","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77050477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-11DOI: 10.15226/2378-1726/6/5/001102
I. Temelkova, G. Tchernev
{"title":"Isolated palmar located postherpetic Erythema multiforme: unique pathognomonic clinical presentation!","authors":"I. Temelkova, G. Tchernev","doi":"10.15226/2378-1726/6/5/001102","DOIUrl":"https://doi.org/10.15226/2378-1726/6/5/001102","url":null,"abstract":"","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79138849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-11DOI: 10.15226/2378-1726/6/5/001101
I. Temelkova, G. Tchernev
{"title":"Congenital Bilateral ocular hypoplasia associated with bilateral manifestation of Klippel- Trenaunay- Weber syndrome of the lower extremities: uncommon presentation in a Bulgarian patient with dermatitis hypostatica!","authors":"I. Temelkova, G. Tchernev","doi":"10.15226/2378-1726/6/5/001101","DOIUrl":"https://doi.org/10.15226/2378-1726/6/5/001101","url":null,"abstract":"","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80455959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.15226/2378-1726/6/4/001100
I. Temelkova, J. Cardoso, G. Tchernev
{"title":"Chronic tophaceous gout: Unique presentation in a Bulgarian patient!","authors":"I. Temelkova, J. Cardoso, G. Tchernev","doi":"10.15226/2378-1726/6/4/001100","DOIUrl":"https://doi.org/10.15226/2378-1726/6/4/001100","url":null,"abstract":"","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73858254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.15226/2378-1726/6/4/00199
I. Temelkova, J. Cardoso, G. Tchernev
We present a 47 year-old woman with histologically and serologically confirmed subacute cutaneous lupus erythematosus since 2009. The initial clinical appearance of the lesions was that of polycyclic and monocyclic annular plaques, located on the face, trunk and extremities (Figs 1a, 1b). The patient was initially treated with oral chloroquine phosphate 250mg/daily in combination with 40 mg intravenous methylprednisolone, leading to control of the disease, and subsequently tapered until a maintenance oral dose of 4 mg over time.
{"title":"Bulgarian patient with Rowell syndrome!","authors":"I. Temelkova, J. Cardoso, G. Tchernev","doi":"10.15226/2378-1726/6/4/00199","DOIUrl":"https://doi.org/10.15226/2378-1726/6/4/00199","url":null,"abstract":"We present a 47 year-old woman with histologically and serologically confirmed subacute cutaneous lupus erythematosus since 2009. The initial clinical appearance of the lesions was that of polycyclic and monocyclic annular plaques, located on the face, trunk and extremities (Figs 1a, 1b). The patient was initially treated with oral chloroquine phosphate 250mg/daily in combination with 40 mg intravenous methylprednisolone, leading to control of the disease, and subsequently tapered until a maintenance oral dose of 4 mg over time.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85235104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.15226/2378-1726/6/4/00198
J. Penev, M. Balabanova, I. Bakardzhiev
Individual well-being and self-esteem related to appearance of patients with multiple seborrheic keratoses (MSK), as well asan original strategy for complete removal of all lesions with CO2 laser are discussed. Presented are examples from our dermatological practice illustrating negative psycho-social impact of multiple SK on individual well-being. Seborrheic keratosis is considered a widespread dermatosis, as well as a cosmetic issue for its presence creates an overall impression of prematurely aged, and a “shabby” looking skin. Individuals with multiple SK often suffer low self-esteem in terms of their appearance which may improve after the aesthetic CO2 laser complete elimination of MSK lesions.
{"title":"Strategy of Aesthetic Laser Removal of Multiple Seborrheic Keratosis and Effects on Appearance’ Self- Esteem and Well-Being","authors":"J. Penev, M. Balabanova, I. Bakardzhiev","doi":"10.15226/2378-1726/6/4/00198","DOIUrl":"https://doi.org/10.15226/2378-1726/6/4/00198","url":null,"abstract":"Individual well-being and self-esteem related to appearance of patients with multiple seborrheic keratoses (MSK), as well asan original strategy for complete removal of all lesions with CO2 laser are discussed. Presented are examples from our dermatological practice illustrating negative psycho-social impact of multiple SK on individual well-being. Seborrheic keratosis is considered a widespread dermatosis, as well as a cosmetic issue for its presence creates an overall impression of prematurely aged, and a “shabby” looking skin. Individuals with multiple SK often suffer low self-esteem in terms of their appearance which may improve after the aesthetic CO2 laser complete elimination of MSK lesions.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"273 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73055654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-14DOI: 10.15226/2378-1726/6/4/00197
I. Temelkova, G. Tchernev
The group of cutaneous T-cell lymphomas (CTCL) or the so-called Mycosis fungoides (MF) is also referred to as a “great imitator" and in some cases may be misinterpreted as benign inflammatory skin disorders. Difficulties could arise both clinically and histopathologically, especially in the early stages of the disease. For this reason, it is recommended that the diagnosis of MF to follow a three-stage pattern of behavior and be performed on the basis of clinic, histopathology and immunohistochemistry.
{"title":"Erythema chronicum migrans like- T cell lymphoma: First description in the medical literature. Successful management with methotrexate and methylprednisolone aceponate!","authors":"I. Temelkova, G. Tchernev","doi":"10.15226/2378-1726/6/4/00197","DOIUrl":"https://doi.org/10.15226/2378-1726/6/4/00197","url":null,"abstract":"The group of cutaneous T-cell lymphomas (CTCL) or the so-called Mycosis fungoides (MF) is also referred to as a “great imitator\" and in some cases may be misinterpreted as benign inflammatory skin disorders. Difficulties could arise both clinically and histopathologically, especially in the early stages of the disease. For this reason, it is recommended that the diagnosis of MF to follow a three-stage pattern of behavior and be performed on the basis of clinic, histopathology and immunohistochemistry.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75103383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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