Pub Date : 2019-08-07DOI: 10.15226/2378-1726/6/3/00195
G. Tchernev, I. Temelkova
We present a 43-year-old female with congenital melanocytic lesion in the area of the left thigh [Figure 1a]. Within the last 1 year, the patient observed a change in the color of the formation and an increase in its size. Within the dermatological examination on the lateral side of the left thigh, the presence of a pigment asymmetric lesion with a size of 1,5/2 cm, clear distortion from healthy tissue at the periphery, loss of pigmentation between 9: 00-11: 00 hours, irregular diameter and significant elevation in the upper two-thirds of the lesion, was observed [Figures 1ab]. Clinically and dermatoscopically (loss of pigment network and presence of pale pink and gray regression areas) data were indicative for melanoma of less than 1 mm or melanoma in situ [Fig. 1a]. Preoperative ultrasound examination of tumor thickness was not performed. The screening was without data for dissemination of the process. An operation was performed by the of One step melanoma surgery (OSMS) method, and the lesion was removed by elliptical excision with a direct surgical field of 1 cm in all directions [Figure 1c-d]. The resulting surgical defect was closed by single interrupted sutures [Figure 1e]. The post-operative histological examination confirmed the initial (clinical/ dermatoscopic) diagnosis, namely that it is melanoma in situ, with clear resection lines. A smooth post-operative period without complications was observed.
{"title":"One step melanoma surgery (OSMS) for thin melanomas and melanoma in situ: Undoubtedly the perfect and most adequate therapeutic Approach!","authors":"G. Tchernev, I. Temelkova","doi":"10.15226/2378-1726/6/3/00195","DOIUrl":"https://doi.org/10.15226/2378-1726/6/3/00195","url":null,"abstract":"We present a 43-year-old female with congenital melanocytic lesion in the area of the left thigh [Figure 1a]. Within the last 1 year, the patient observed a change in the color of the formation and an increase in its size. Within the dermatological examination on the lateral side of the left thigh, the presence of a pigment asymmetric lesion with a size of 1,5/2 cm, clear distortion from healthy tissue at the periphery, loss of pigmentation between 9: 00-11: 00 hours, irregular diameter and significant elevation in the upper two-thirds of the lesion, was observed [Figures 1ab]. Clinically and dermatoscopically (loss of pigment network and presence of pale pink and gray regression areas) data were indicative for melanoma of less than 1 mm or melanoma in situ [Fig. 1a]. Preoperative ultrasound examination of tumor thickness was not performed. The screening was without data for dissemination of the process. An operation was performed by the of One step melanoma surgery (OSMS) method, and the lesion was removed by elliptical excision with a direct surgical field of 1 cm in all directions [Figure 1c-d]. The resulting surgical defect was closed by single interrupted sutures [Figure 1e]. The post-operative histological examination confirmed the initial (clinical/ dermatoscopic) diagnosis, namely that it is melanoma in situ, with clear resection lines. A smooth post-operative period without complications was observed.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90451122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-07DOI: 10.15226/2378-1726/6/4/00196
I. Temelkova, V. Malev, G. Tchernev
A 42 year old male patient visited the dermatological department with a complaint for suddenly appeared and curious looking lesion in the area of the back (fig. 1a-b). Respectively, the lesion was painless, but caused some cosmetic concerns. According to the anamnestic data several days before the clinical examination the formation has been treated by a surgeon with electrocautery, resulting in а partial remission of the lesion. A tissue sample has not been collected and no histopathological data was available at the time. During the dermatological examination the presence of blackberry like, around 5mm, elevated, lobulated lesion was established in the area of the back (fig. 1a-b). Additionally, circular redness was visualized around the lesion (fig. 1a-b). Based on clinic and dermatoscopy, the possibility of cutaneous hemangioma or melanoma was considered. Surgical removal of the lesion was performed with a direct operational safety margin of 1 cm in all directions. Subsequent histological examination revealed the presence of capillary hemangioma with clear resection lines.
{"title":"Blackberry-like lesion of the back: One Step melanoma surgery (OSMS) as possible treatment approach even when melanoma only suspected!?","authors":"I. Temelkova, V. Malev, G. Tchernev","doi":"10.15226/2378-1726/6/4/00196","DOIUrl":"https://doi.org/10.15226/2378-1726/6/4/00196","url":null,"abstract":"A 42 year old male patient visited the dermatological department with a complaint for suddenly appeared and curious looking lesion in the area of the back (fig. 1a-b). Respectively, the lesion was painless, but caused some cosmetic concerns. According to the anamnestic data several days before the clinical examination the formation has been treated by a surgeon with electrocautery, resulting in а partial remission of the lesion. A tissue sample has not been collected and no histopathological data was available at the time. During the dermatological examination the presence of blackberry like, around 5mm, elevated, lobulated lesion was established in the area of the back (fig. 1a-b). Additionally, circular redness was visualized around the lesion (fig. 1a-b). Based on clinic and dermatoscopy, the possibility of cutaneous hemangioma or melanoma was considered. Surgical removal of the lesion was performed with a direct operational safety margin of 1 cm in all directions. Subsequent histological examination revealed the presence of capillary hemangioma with clear resection lines.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82005361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-07DOI: 10.15226/2378-1726/6/3/00194
V. Malev, I. Temelkova, G. Tchernev
Hemangiomas are benign tumors, most commonly located in the head and neck region, showing a notoriously higher prevalence in females (3:1). They usually affect eyelids, lips, nose, chin and oral cavity [1,2]. Hemangiomas are mainly divided into congenital and acquired type. Path morphologically they are classified as capillary, cavernous or miscellaneous forms, and according to their depth as superficial, deep or compound. The evolution of hemangiomas usually goes through three stages: endothelial cell proliferation, accelerated growth and involution. The involution of congenital hemangiomas in turn can be like rapidly involuting congenital hemangioma (RICH) or never involute (noninvoluting congenital hemangioma; (NICH). According to the literature hemangiomas are a common tumor in infancy, and they usually resolve within the age of 10 [1, 3].
{"title":"Giant Congenital Hemangioma of the Tongue: sporadic finding in a female Bulgarian patient with Hidradenitis suppurativa!","authors":"V. Malev, I. Temelkova, G. Tchernev","doi":"10.15226/2378-1726/6/3/00194","DOIUrl":"https://doi.org/10.15226/2378-1726/6/3/00194","url":null,"abstract":"Hemangiomas are benign tumors, most commonly located in the head and neck region, showing a notoriously higher prevalence in females (3:1). They usually affect eyelids, lips, nose, chin and oral cavity [1,2]. Hemangiomas are mainly divided into congenital and acquired type. Path morphologically they are classified as capillary, cavernous or miscellaneous forms, and according to their depth as superficial, deep or compound. The evolution of hemangiomas usually goes through three stages: endothelial cell proliferation, accelerated growth and involution. The involution of congenital hemangiomas in turn can be like rapidly involuting congenital hemangioma (RICH) or never involute (noninvoluting congenital hemangioma; (NICH). According to the literature hemangiomas are a common tumor in infancy, and they usually resolve within the age of 10 [1, 3].","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89890433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.15226/2378-1726/6/3/00192
G. Tchernev, I. Temelkova
The main purpose of the analyzes carried out by the colleagues in an recently published paper in PNAS-USA [Proceedings of the National Academy of Science of the United States of America) is focused 1) on the one hand on the in vitro effect of Losartan in murine ovarian carcinoma model, demonstrating that the adjuvant effect of losartan should be definitely synergistic with regard to the parallel-induced / or ongoing chemotherapy, and on the other hand 2) in addition, that malignant ascites in retrospectively observed patient group seems to be also reduced [1].
{"title":"Losartan: Reduces Ascites, but induces Cancer? Again Some Stupid Statements from PNAS- Proceedings of the National Academy of Science of USA!","authors":"G. Tchernev, I. Temelkova","doi":"10.15226/2378-1726/6/3/00192","DOIUrl":"https://doi.org/10.15226/2378-1726/6/3/00192","url":null,"abstract":"The main purpose of the analyzes carried out by the colleagues in an recently published paper in PNAS-USA [Proceedings of the National Academy of Science of the United States of America) is focused 1) on the one hand on the in vitro effect of Losartan in murine ovarian carcinoma model, demonstrating that the adjuvant effect of losartan should be definitely synergistic with regard to the parallel-induced / or ongoing chemotherapy, and on the other hand 2) in addition, that malignant ascites in retrospectively observed patient group seems to be also reduced [1].","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"2014 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74244505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-01DOI: 10.15226/2378-1726/6/3/00193
G. Tchernev, I. Temelkova
Again we would like to focus the attention to a case of valsartan induced melanoma: a patient who has received two medical products (combined drug of amlodipine and valsartan 10/ 160mg (1-0-0), in the period 2008 to 2018, and additional valsartan 160mg (0-0-1) from 2015 that 1) the suspected primary melanocytic lesion was acquired one and occurred about three years after the start of the treatment with two different sartans 2) progression to cutaneous melanoma was observed when the dose of the valsartan was doubled within a period of 2,5 years, and 3) the exact application of the guidelines of AJCC for surgical treatment of cutaneous melanoma does not protect from melanoma progression (as in the case described by us) unlike the OSMS surgical model in which this progression is absent [3,4]. And what seems to be extraordinary is that 4) the progression of cutaneous melanoma to stage 4 was actually observed in a patient who was initially treated with two different sartans, produced from the same company that produces the Dabrafenib and Trametinib medication : the most widespread medications for treatment of melanoma at the moment [1]! Drugs, which have been subsequently used to treat ʺourʺ patient also?!
{"title":"Big Pharma Paradoxes (BPP): Selling simultaneously drugs which Induce and Treat melanomas: \"The simple example for complicated Relations!\"","authors":"G. Tchernev, I. Temelkova","doi":"10.15226/2378-1726/6/3/00193","DOIUrl":"https://doi.org/10.15226/2378-1726/6/3/00193","url":null,"abstract":"Again we would like to focus the attention to a case of valsartan induced melanoma: a patient who has received two medical products (combined drug of amlodipine and valsartan 10/ 160mg (1-0-0), in the period 2008 to 2018, and additional valsartan 160mg (0-0-1) from 2015 that 1) the suspected primary melanocytic lesion was acquired one and occurred about three years after the start of the treatment with two different sartans 2) progression to cutaneous melanoma was observed when the dose of the valsartan was doubled within a period of 2,5 years, and 3) the exact application of the guidelines of AJCC for surgical treatment of cutaneous melanoma does not protect from melanoma progression (as in the case described by us) unlike the OSMS surgical model in which this progression is absent [3,4]. And what seems to be extraordinary is that 4) the progression of cutaneous melanoma to stage 4 was actually observed in a patient who was initially treated with two different sartans, produced from the same company that produces the Dabrafenib and Trametinib medication : the most widespread medications for treatment of melanoma at the moment [1]! Drugs, which have been subsequently used to treat ʺourʺ patient also?!","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87809303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-26DOI: 10.15226/2378-1726/6/2/00188
G. Tchernev, Konstantin Stavrov, U. Wollina, I. Temelkova
Grover’s disease is a transient acantholytic dermatosis that usually disappears within a few weeks, but it can also be presented as a persistent variant with a duration of more than 3 years. The etiology of this disease is not entirely clear and possible causes include viral infections, drug reactions (BRAF inhibitors and allogeneic haematopoietic stem cell transplantation). In terms of treatment, topical and systemic steroids, oral vitamin A and PUVA therapy are described. We present a 79-year-old man with a 1-month complaint for a recurring, highly itchy, blistering rash on the skin of the upper limbs, back and chest. During the clinical examination, there was an erythemo-papulo-vesicular polymorphic rash , in places with xerosis areas, engaging the upper part of the trunk, as the initial data and subsequent histopathological verification data spoke undoubtly in direction of acantholytic dermatosis or Grover’s disease .During hospitalization, systemic antihistamine and topical steroid therapy was performed. Subsequently, ambulatory therapy with Acitretin 20 mg /daily per os and Methylprednisolone aceponate 0.1% x 2 / daily topically was given with a good therapeutic response. We believe that this case seems to be the first officially documented case of Morbus Grover associated with idiopathic low-grade thrombocytopenia. Key words: Morbus Grover; Idiopathic thrombocytopenia; Acitretin; Prednisolone; PSA
格罗弗氏病是一种短暂的棘皮溶解性皮肤病，通常在几周内消失，但它也可以表现为持续3年以上的持久变体。该病的病因尚不完全清楚，可能的病因包括病毒感染、药物反应(BRAF抑制剂和异体造血干细胞移植)。在治疗方面，描述了局部和全身类固醇，口服维生素A和PUVA治疗。我们报告一位79岁的男性，因上肢，背部和胸部皮肤反复出现高度瘙痒，起泡皮疹而抱怨1个月。在临床检查中，有一个红斑丘疹多形皮疹，在干燥的地方，累及躯干上部，初步资料和随后的组织病理学验证资料无疑地表明棘囊性皮肤病或Grover病。住院期间，进行了全身抗组胺和局部类固醇治疗。随后，给予阿维甲素20mg /d / s和醋酸甲泼尼龙0.1% x 2 /d局部门诊治疗，治疗效果良好。我们相信这个病例似乎是第一个正式记录的Morbus Grover与特发性低级别血小板减少症相关的病例。关键词:Morbus Grover;特发性血小板减少;Acitretin;强的松;PSA
{"title":"Transient Acantholytic Dermatosis (Grover's Disease) in a Bulgarian Patient Associated With Idiopathic Low-Grade Thrombocytopenia: First Description in the Medical Literature!","authors":"G. Tchernev, Konstantin Stavrov, U. Wollina, I. Temelkova","doi":"10.15226/2378-1726/6/2/00188","DOIUrl":"https://doi.org/10.15226/2378-1726/6/2/00188","url":null,"abstract":"Grover’s disease is a transient acantholytic dermatosis that usually disappears within a few weeks, but it can also be presented as a persistent variant with a duration of more than 3 years. The etiology of this disease is not entirely clear and possible causes include viral infections, drug reactions (BRAF inhibitors and allogeneic haematopoietic stem cell transplantation). In terms of treatment, topical and systemic steroids, oral vitamin A and PUVA therapy are described. We present a 79-year-old man with a 1-month complaint for a recurring, highly itchy, blistering rash on the skin of the upper limbs, back and chest. During the clinical examination, there was an erythemo-papulo-vesicular polymorphic rash , in places with xerosis areas, engaging the upper part of the trunk, as the initial data and subsequent histopathological verification data spoke undoubtly in direction of acantholytic dermatosis or Grover’s disease .During hospitalization, systemic antihistamine and topical steroid therapy was performed. Subsequently, ambulatory therapy with Acitretin 20 mg /daily per os and Methylprednisolone aceponate 0.1% x 2 / daily topically was given with a good therapeutic response. We believe that this case seems to be the first officially documented case of Morbus Grover associated with idiopathic low-grade thrombocytopenia. Key words: Morbus Grover; Idiopathic thrombocytopenia; Acitretin; Prednisolone; PSA","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89147804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-26DOI: 10.15226/2378-1726/6/3/00191
I. Temelkova, U. Wollina, Konstantin Stavrov, I. Yungareva, G. Tchernev
According to the literature data, pityriasis lichenoides chronica (PLC) can also be considered as a drug-induced disease among many other possible causes, e.g. parainfectious!. Currently, the following medications are described as possible triggers among drugs: antidepressants and statins, adalimumab, HMG-CoA reductase inhibitors, pemetrexed and infliximab. We present a 82-year-old man with ischemic cerebral infarction on the occasion of which he accepts acetylsalicylic acid 100mg (0-0-1) since December 2018. According to the patient, immediately (or about 2 months) after starting medication with acetylsalicylic acid, he observed raised itchy lesions on the skin of the trunk. During the dermatological examination, presence of disseminated erythemo-papulous, partially lichenoid lesions, excoriations and fine desquamation was established on the skin of the trunk and the extremities. Possibility for pityriasis lichenoides chronica, parapsoriasis small plaque form or lichen planus was considered. A skin biopsy was taken, and histological examination revealed evidence for pityriasis lichenoides chronica. Due to the suspicion for drug induced pityriasis, acetylsalicylic acid treatment was discontinued and replaced with clopidogrel. After a period of 6 weeks, we observed a good clinical response and reversal of the skin symptoms. We present the first case of acetylsalicylic acid induced PLC think the conclusion with certainty is not possible. Only the disappearance after change of medication does not prove the induction by ASS. In case of recurrence of the skin changes after reexposition with ASS could prove the causative role of ASS. Patients with this type of disease should be closely monitored because of the possibility for development of lymphoproliferative disorders.
{"title":"Drug Induced (Acetylsalicylic Acid/ASS) Pityriasis Lichenoides Chronica: First Report In The Medical Literature!?","authors":"I. Temelkova, U. Wollina, Konstantin Stavrov, I. Yungareva, G. Tchernev","doi":"10.15226/2378-1726/6/3/00191","DOIUrl":"https://doi.org/10.15226/2378-1726/6/3/00191","url":null,"abstract":"According to the literature data, pityriasis lichenoides chronica (PLC) can also be considered as a drug-induced disease among many other possible causes, e.g. parainfectious!. Currently, the following medications are described as possible triggers among drugs: antidepressants and statins, adalimumab, HMG-CoA reductase inhibitors, pemetrexed and infliximab. We present a 82-year-old man with ischemic cerebral infarction on the occasion of which he accepts acetylsalicylic acid 100mg (0-0-1) since December 2018. According to the patient, immediately (or about 2 months) after starting medication with acetylsalicylic acid, he observed raised itchy lesions on the skin of the trunk. During the dermatological examination, presence of disseminated erythemo-papulous, partially lichenoid lesions, excoriations and fine desquamation was established on the skin of the trunk and the extremities. Possibility for pityriasis lichenoides chronica, parapsoriasis small plaque form or lichen planus was considered. A skin biopsy was taken, and histological examination revealed evidence for pityriasis lichenoides chronica. Due to the suspicion for drug induced pityriasis, acetylsalicylic acid treatment was discontinued and replaced with clopidogrel. After a period of 6 weeks, we observed a good clinical response and reversal of the skin symptoms. We present the first case of acetylsalicylic acid induced PLC think the conclusion with certainty is not possible. Only the disappearance after change of medication does not prove the induction by ASS. In case of recurrence of the skin changes after reexposition with ASS could prove the causative role of ASS. Patients with this type of disease should be closely monitored because of the possibility for development of lymphoproliferative disorders.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75090897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-26DOI: 10.15226/2378-1726/6/2/00189
G. Tchernev, U. Wollina, Konstantin Stavrov, I. Temelkova
Background: There are different literature data according to which small plaque parapsoriasis (SPP) and guttate parapsoriasis could be considered as part of the various clinical forms of MF. However, there are no literature data that compare different control groups of patients (receiving/ not taking antihypertensive medication) and the two important possibilities deriving from it, namely: 1) that certain drug forms could be inducers of parapsoriasis and 2) that other drug forms could potentiate the transformation of existing parapsoriasis into T-cell lymphoma. We describe a case of possible infectious and / or drug-induced SPP by discussing an important, albeit currently hypothetical link to the drug mediated cancerogenesis. Case report: We present a 39-year-old man with a disseminated eruptive erythemo-papulo-squamous rash, localized on the skin of the trunk and extremities. According to anamnestic data, skin symptoms date back to about 1 month when the patient was hospitalized in the ENT compartment for severe throat pain. Primary empirical antibiotic therapy with clindamycin 4x 600mg/ daily i.v was performed on a regimen and partial remission was achieved. Immediately afterwards there was a resumption of symptoms and the additional occurrence of skin lesions. From the conducted tests, the presence of acute tonsillopharyngitis, focal infection of dental origin and elevated antistreptolysin titer was found. In parallel, the patient receives antihypertensive therapy (ACE inhibitor and beta blocker) on the occasion of arterial hypertension. There was a suspicion for infectious and / or drug-triggered psoriasis gutata, as the subsequent histological study showed evidence of small plaque parapsoriasis. Conclusion: Although there are a number of literature data on the relationship between antihypertensive drugs and their pro-or anticancerogenic action against various types of tumors, there is currently no data available to compare the existing risk of developing T- cell lymphoma in patients with SPP and concomitant cardiac therapy with ACE inhibitors and beta blockers. We present a patient with triple histologically verified small plaque parapsoriasis and we are discussing a completely new pathogenetic element: triggering in the framework a possible chronic infection and systemic antihypertensive therapy. The selected retrospective or prospective analysis of wider groups of patients with chronic infections / systemic antihypertensive medication as well as proven T cell lymphomas could provide clarity with respect to the shared by us observations in single patients. Keywords: Small plaque parapsoriasis; antihypertensive drugs; chronic infections; triggers; drug mediated cancerogenesis;
{"title":"Antihypertensive Drugs (АCE- Inhibitors/ Beta- Blockers) and Chronic Infections as Potential Triggers for the Spontaneously Development of Small Plaque Parapsoriasis ?!","authors":"G. Tchernev, U. Wollina, Konstantin Stavrov, I. Temelkova","doi":"10.15226/2378-1726/6/2/00189","DOIUrl":"https://doi.org/10.15226/2378-1726/6/2/00189","url":null,"abstract":"Background: There are different literature data according to which small plaque parapsoriasis (SPP) and guttate parapsoriasis could be considered as part of the various clinical forms of MF. However, there are no literature data that compare different control groups of patients (receiving/ not taking antihypertensive medication) and the two important possibilities deriving from it, namely: 1) that certain drug forms could be inducers of parapsoriasis and 2) that other drug forms could potentiate the transformation of existing parapsoriasis into T-cell lymphoma. We describe a case of possible infectious and / or drug-induced SPP by discussing an important, albeit currently hypothetical link to the drug mediated cancerogenesis. Case report: We present a 39-year-old man with a disseminated eruptive erythemo-papulo-squamous rash, localized on the skin of the trunk and extremities. According to anamnestic data, skin symptoms date back to about 1 month when the patient was hospitalized in the ENT compartment for severe throat pain. Primary empirical antibiotic therapy with clindamycin 4x 600mg/ daily i.v was performed on a regimen and partial remission was achieved. Immediately afterwards there was a resumption of symptoms and the additional occurrence of skin lesions. From the conducted tests, the presence of acute tonsillopharyngitis, focal infection of dental origin and elevated antistreptolysin titer was found. In parallel, the patient receives antihypertensive therapy (ACE inhibitor and beta blocker) on the occasion of arterial hypertension. There was a suspicion for infectious and / or drug-triggered psoriasis gutata, as the subsequent histological study showed evidence of small plaque parapsoriasis. Conclusion: Although there are a number of literature data on the relationship between antihypertensive drugs and their pro-or anticancerogenic action against various types of tumors, there is currently no data available to compare the existing risk of developing T- cell lymphoma in patients with SPP and concomitant cardiac therapy with ACE inhibitors and beta blockers. We present a patient with triple histologically verified small plaque parapsoriasis and we are discussing a completely new pathogenetic element: triggering in the framework a possible chronic infection and systemic antihypertensive therapy. The selected retrospective or prospective analysis of wider groups of patients with chronic infections / systemic antihypertensive medication as well as proven T cell lymphomas could provide clarity with respect to the shared by us observations in single patients. Keywords: Small plaque parapsoriasis; antihypertensive drugs; chronic infections; triggers; drug mediated cancerogenesis;","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78782955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-26DOI: 10.15226/2378-1726/6/2/00190
G. Tchernev, U. Wollina, I. Temelkova
G Tchernev1˒2*, U Wollina3 and I Temelkova1˒2 1Department of Dermatology, Venereology and Dermatologic surgery, Medical Institute of Ministry of Interior (MVR); Sofia, Bulgaria 2OnkodermaClinic for Dermatology, Venereology and Dermatologic Surgery; Sofia, Bulgaria 3Department of Dermatology and Allergology, Stadtisches Klinikum Dresden, Germany Clinical Research in Dermatology: Open Access Open Access Letter to Editor
{"title":"Multi-Drug Induced Palmar and Plantar Lichen Planus: First Description in the Medical Literature!","authors":"G. Tchernev, U. Wollina, I. Temelkova","doi":"10.15226/2378-1726/6/2/00190","DOIUrl":"https://doi.org/10.15226/2378-1726/6/2/00190","url":null,"abstract":"G Tchernev1˒2*, U Wollina3 and I Temelkova1˒2 1Department of Dermatology, Venereology and Dermatologic surgery, Medical Institute of Ministry of Interior (MVR); Sofia, Bulgaria 2OnkodermaClinic for Dermatology, Venereology and Dermatologic Surgery; Sofia, Bulgaria 3Department of Dermatology and Allergology, Stadtisches Klinikum Dresden, Germany Clinical Research in Dermatology: Open Access Open Access Letter to Editor","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88346264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-20DOI: 10.15226/2378-1726/6/2/00187
H. Yingjian, Duan Qiqi, W. Ning, Zheng Yan
Background: Skin basal cell carcinoma (BCC) is the most common skin cancer with an increasing incidence rate worldwide. XB130 is a novel adaptor protein for intracellular signal transduction and it participates in cell proliferation, cell survival, cell migration and cell apoptosis. Studies have demonstrated that XB130 is involved in cancer initiation and progression; however, its expression and role in BCC have not been investigated. Methods: Immunohistochemistry was carried out to detect the expression of XB130 at protein level in skin samples obtained from patients with skin basal cell carcinoma (n=40) and healthy donors (n=35). Results: In our study, we found that the staining of XB130 was mostly observed in cytoplasm. In normal skin tissues, XB130 was expressed almost in the whole layer of the epidermis. And the expression of XB130 in BCC was significantly down-regulated compared to normal skin. Conclusions: The study suggested that XB130 is involved in the pathogenesis of BCC and it may serve as a therapeutic target of BCC. Keywords: XB130; skin basal cell carcinoma;
{"title":"The Expression and Significance of XB130 in Skin Basal Cell Carcinoma","authors":"H. Yingjian, Duan Qiqi, W. Ning, Zheng Yan","doi":"10.15226/2378-1726/6/2/00187","DOIUrl":"https://doi.org/10.15226/2378-1726/6/2/00187","url":null,"abstract":"Background: Skin basal cell carcinoma (BCC) is the most common skin cancer with an increasing incidence rate worldwide. XB130 is a novel adaptor protein for intracellular signal transduction and it participates in cell proliferation, cell survival, cell migration and cell apoptosis. Studies have demonstrated that XB130 is involved in cancer initiation and progression; however, its expression and role in BCC have not been investigated. Methods: Immunohistochemistry was carried out to detect the expression of XB130 at protein level in skin samples obtained from patients with skin basal cell carcinoma (n=40) and healthy donors (n=35). Results: In our study, we found that the staining of XB130 was mostly observed in cytoplasm. In normal skin tissues, XB130 was expressed almost in the whole layer of the epidermis. And the expression of XB130 in BCC was significantly down-regulated compared to normal skin. Conclusions: The study suggested that XB130 is involved in the pathogenesis of BCC and it may serve as a therapeutic target of BCC. Keywords: XB130; skin basal cell carcinoma;","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77316769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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