Pub Date : 2019-06-17DOI: 10.15226/2378-1726/6/2/00186
Abdul Kader Mohiuddin
Acne, also known as acne vulgaris (AV), is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. It is characterized by blackheads or whiteheads, pimples, oily skin, and possible scarring. An intact stratum corneum and barrier, normal natural moisturizing factor and hyaluronic acid levels, normal Aquaporin-3 (AQP3) expression (localized at the basal lateral membranes of collecting duct cells in the kidney), and balanced sebum secretion are qualities of the skin that fall in the middle of the oily–dry spectrum. Patients rarely, if ever, complain about reduced sebum production, but elevated sebum production, yielding oily skin that can be a precursor to acne, is a common complaint. Several factors are known to influence sebum production. AV is mostly triggered by Propionibacterium acnes in adolescence, under the influence of normal circulating dehydroepiandrosterone (DHEA). It is a very common skin disorder which can present with inflammatory and noninflammatory lesions chiefly on the face but can also occur on the upper arms, trunk, and back. Age, in particular, has a significant and well-known impact, as sebum levels are usually low in childhood, rise in the middle-to-late teen years, and remain stable into the seventh and eighth decades until endogenous androgen synthesis dwindles. Sebum, the oily secretion of the sebaceous glands containing wax esters, sterol esters, cholesterol, di- and triglycerides, and squalene, imparts an oily quality to the skin and is well known to play an important role in acne development. Acne can’t be prevented or cured, but it can be treated effectively. The pimples and bumps heal slowly, and when one begins to go away, others seem to crop up. Depending on its severity, acne can cause emotional distress and scar the skin. Acne may cause scarring of the skin, but generally causes no long-term health problems. In self-body image, some parts of the body including face play an important role. Existence of even a minor lesion in this part may be unpleasant for the patient and seems large. This image can cause mental disorders including depression and anxiety, low self-esteem, and decrease in social relationships. However, high levels of anxiety and depression in patients with facial acne are not related to oxidative stress, according to a study published online in the Journal of Cosmetic Dermatology
{"title":"A Comprehensive Review of Acne Vulgaris","authors":"Abdul Kader Mohiuddin","doi":"10.15226/2378-1726/6/2/00186","DOIUrl":"https://doi.org/10.15226/2378-1726/6/2/00186","url":null,"abstract":"Acne, also known as acne vulgaris (AV), is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. It is characterized by blackheads or whiteheads, pimples, oily skin, and possible scarring. An intact stratum corneum and barrier, normal natural moisturizing factor and hyaluronic acid levels, normal Aquaporin-3 (AQP3) expression (localized at the basal lateral membranes of collecting duct cells in the kidney), and balanced sebum secretion are qualities of the skin that fall in the middle of the oily–dry spectrum. Patients rarely, if ever, complain about reduced sebum production, but elevated sebum production, yielding oily skin that can be a precursor to acne, is a common complaint. Several factors are known to influence sebum production. AV is mostly triggered by Propionibacterium acnes in adolescence, under the influence of normal circulating dehydroepiandrosterone (DHEA). It is a very common skin disorder which can present with inflammatory and noninflammatory lesions chiefly on the face but can also occur on the upper arms, trunk, and back. Age, in particular, has a significant and well-known impact, as sebum levels are usually low in childhood, rise in the middle-to-late teen years, and remain stable into the seventh and eighth decades until endogenous androgen synthesis dwindles. Sebum, the oily secretion of the sebaceous glands containing wax esters, sterol esters, cholesterol, di- and triglycerides, and squalene, imparts an oily quality to the skin and is well known to play an important role in acne development. Acne can’t be prevented or cured, but it can be treated effectively. The pimples and bumps heal slowly, and when one begins to go away, others seem to crop up. Depending on its severity, acne can cause emotional distress and scar the skin. Acne may cause scarring of the skin, but generally causes no long-term health problems. In self-body image, some parts of the body including face play an important role. Existence of even a minor lesion in this part may be unpleasant for the patient and seems large. This image can cause mental disorders including depression and anxiety, low self-esteem, and decrease in social relationships. However, high levels of anxiety and depression in patients with facial acne are not related to oxidative stress, according to a study published online in the Journal of Cosmetic Dermatology","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90198829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-10DOI: 10.15226/2378-1726/6/1/00185
P. Julian, I. Krasnaliev, I. Bakardzhiev
Osteoma cutis, also called multiple miliary osteoma cutis is a rarely described dermatosis, and in cases that are not associated with Albright’s hereditary osteodystrophy, osteoma cutis is being defined as a skin type of hamartoma, with mesenchymal cell differentiation in bone tissue. Levels of biochemical parameters (such as serum calcium, alkaline phosphatase and parathormones) are usually within the reference range when dermal osteomas are found. When osteoma cutis formations are X-ray detected (as it often happens when a computer tomography for dental purposes is performed) they manifest as small nodules in the skin with bone density ranging from 1 to 3mm. The very few presence in literature of osteoma cutis cases is due to the fact that the condition is usually asymptomatic and/or its scarce expression is misdiagnosed as milia, fatty hyperplasia or fatty cysts. Reported in this paper are 14 (fourteen) cases of osteoma cutis. It is discussed their occurrence is due to chronic inflammatory processes (acne), and/or pathogenic behavior of skin injuring (patomimia) that unlock suppressed genes (paleo genes) to protect the skin, that are similar to the bone tiles (osteoderms) present in many vertebrates.
{"title":"Osteoma cutis - Neoplasia or Paleogenetics?","authors":"P. Julian, I. Krasnaliev, I. Bakardzhiev","doi":"10.15226/2378-1726/6/1/00185","DOIUrl":"https://doi.org/10.15226/2378-1726/6/1/00185","url":null,"abstract":"Osteoma cutis, also called multiple miliary osteoma cutis is a rarely described dermatosis, and in cases that are not associated with Albright’s hereditary osteodystrophy, osteoma cutis is being defined as a skin type of hamartoma, with mesenchymal cell differentiation in bone tissue. Levels of biochemical parameters (such as serum calcium, alkaline phosphatase and parathormones) are usually within the reference range when dermal osteomas are found. When osteoma cutis formations are X-ray detected (as it often happens when a computer tomography for dental purposes is performed) they manifest as small nodules in the skin with bone density ranging from 1 to 3mm. The very few presence in literature of osteoma cutis cases is due to the fact that the condition is usually asymptomatic and/or its scarce expression is misdiagnosed as milia, fatty hyperplasia or fatty cysts. Reported in this paper are 14 (fourteen) cases of osteoma cutis. It is discussed their occurrence is due to chronic inflammatory processes (acne), and/or pathogenic behavior of skin injuring (patomimia) that unlock suppressed genes (paleo genes) to protect the skin, that are similar to the bone tiles (osteoderms) present in many vertebrates.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87690668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-06-03DOI: 10.15226/2378-1726/6/1/00184
Meng Liu, Yan Zheng, Mengdi Zhang, Q. Duan, S. Xiao
Cutaneous squamous cell carcinoma (cSCC) is one of the common non-melanoma skin malignant tumors with sophisticated pathogenesis. FOXE1 is considered to be a tumor suppressor involved in the development of various tumors; however, the expression and significance of FOXE1 in cSCC remains to be investigated.
{"title":"Expression of FOXE1 in Cutaneous Squamous Cell Carcinoma","authors":"Meng Liu, Yan Zheng, Mengdi Zhang, Q. Duan, S. Xiao","doi":"10.15226/2378-1726/6/1/00184","DOIUrl":"https://doi.org/10.15226/2378-1726/6/1/00184","url":null,"abstract":"Cutaneous squamous cell carcinoma (cSCC) is one of the common non-melanoma skin malignant tumors with sophisticated pathogenesis. FOXE1 is considered to be a tumor suppressor involved in the development of various tumors; however, the expression and significance of FOXE1 in cSCC remains to be investigated.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88321097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-15DOI: 10.15226/2378-1726/6/1/00183
J. Penev, I. Bakardzhiev, M. Gospodinova
Tuberous sclerosis (Morbus Bourneville-Pringle) is a rare, multisystemic,autosomal dominant disease, associated with a mutation of either of two genes TSC1 and TSC2, responsible for synthesis of proteins hamartin and tuberin - tumor growth suppressing factors, involved in cell proliferation and differentiation processes. Perhaps the most common findings of TS are angiophibromas - cutaneous manifestations of the disease, serving as clinical pointers to the diagnosis. Different methods are being used to treat facial angiofibromas with little or no success. Treatment with CO2 laser ablation can provide fruitful results in removing facial angiofibromas. Presented is a case of a 40 year-old female patient, diagnosed with tuberous sclerosis with multiple facial angiofibromas, subjected to CO2 laser ablation.
{"title":"Successful CO2 Laser Treatment of Facial Angiofibromas in a Female Patient with Tuberous Sclerosis: Case Report","authors":"J. Penev, I. Bakardzhiev, M. Gospodinova","doi":"10.15226/2378-1726/6/1/00183","DOIUrl":"https://doi.org/10.15226/2378-1726/6/1/00183","url":null,"abstract":"Tuberous sclerosis (Morbus Bourneville-Pringle) is a rare, multisystemic,autosomal dominant disease, associated with a mutation of either of two genes TSC1 and TSC2, responsible for synthesis of proteins hamartin and tuberin - tumor growth suppressing factors, involved in cell proliferation and differentiation processes. Perhaps the most common findings of TS are angiophibromas - cutaneous manifestations of the disease, serving as clinical pointers to the diagnosis. Different methods are being used to treat facial angiofibromas with little or no success. Treatment with CO2 laser ablation can provide fruitful results in removing facial angiofibromas. Presented is a case of a 40 year-old female patient, diagnosed with tuberous sclerosis with multiple facial angiofibromas, subjected to CO2 laser ablation.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73407423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-04DOI: 10.15226/2378-1726/6/1/00182
G. Tchernev, I. Temelkova
Approach variability in melanoma surgery is more likely to be artificially created and refers mainly to: 1) the surgical safety margins; 2) the clinician’s compliance with the patient’s choice to pre-define these margins for a better cosmetic outcome; 3) the interval within which re-excisions may be carried out; 4)discrepancy between the clinically respected and histologically established tumor resection margins; 5)as well as the lack of additional guidelines for re-excisions within the already established differences between the clinically and histologically established resection margin. These ʺinaccuraciesʺ make it difficult to implement the current guidelines and often lead to confusion. We assume that the approach variability is for sure not established and based only on the opinion of the so-called ‘expert groups’!
{"title":"Important about the Manipulations of the Pharmaceutical Concerns, the OSMS (One Step Melanoma Surgery) and the Drug Induced Melanoma: \"You Dream Things; You Say, 'Why?' But I See Things Before My Eyes; And I Say ‘Why Not?’\"","authors":"G. Tchernev, I. Temelkova","doi":"10.15226/2378-1726/6/1/00182","DOIUrl":"https://doi.org/10.15226/2378-1726/6/1/00182","url":null,"abstract":"Approach variability in melanoma surgery is more likely to be artificially created and refers mainly to: 1) the surgical safety margins; 2) the clinician’s compliance with the patient’s choice to pre-define these margins for a better cosmetic outcome; 3) the interval within which re-excisions may be carried out; 4)discrepancy between the clinically respected and histologically established tumor resection margins; 5)as well as the lack of additional guidelines for re-excisions within the already established differences between the clinically and histologically established resection margin. These ʺinaccuraciesʺ make it difficult to implement the current guidelines and often lead to confusion. We assume that the approach variability is for sure not established and based only on the opinion of the so-called ‘expert groups’!","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"135 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79581544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-21DOI: 10.15226/2378-1726/6/1/00181
Mengdi Zhang, Min Wang, Q. Duan, Yan Zheng
RIPK3 is a member of the receptor-interacting protein kinase family. The RIPK3 protein is a TNFR1-regulated transcription factor that plays an important role in cell stress caused by various factors such as pathogen infection, inflammation, cell differentiation and cell damage. When cells are exposed to external stimuli, RIPK3 activates the downstream transcription factors to cause a series of reactions that ultimately lead to cell survival or death. However, the roles of RIPK3 in lichen planus has not been reported. In this study we compared the expression of RIPK3 protein in normal skin tissue and cutaneous lichen planus lesion, and analyzed the epidemiology characteristics of the patients. It is speculated that RIPK3 may play a role in the development of cutaneous lichen planus.
{"title":"The Expression And Significance Of RIPK3 In Cutaneous Lichen Planus And The Epidemiological Analysis","authors":"Mengdi Zhang, Min Wang, Q. Duan, Yan Zheng","doi":"10.15226/2378-1726/6/1/00181","DOIUrl":"https://doi.org/10.15226/2378-1726/6/1/00181","url":null,"abstract":"RIPK3 is a member of the receptor-interacting protein kinase family. The RIPK3 protein is a TNFR1-regulated transcription factor that plays an important role in cell stress caused by various factors such as pathogen infection, inflammation, cell differentiation and cell damage. When cells are exposed to external stimuli, RIPK3 activates the downstream transcription factors to cause a series of reactions that ultimately lead to cell survival or death. However, the roles of RIPK3 in lichen planus has not been reported. In this study we compared the expression of RIPK3 protein in normal skin tissue and cutaneous lichen planus lesion, and analyzed the epidemiology characteristics of the patients. It is speculated that RIPK3 may play a role in the development of cutaneous lichen planus.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75102185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-30DOI: 10.15226/2378-1726/5/2/00180
A. Aguirre, E. Gil-Quintana, Manuel La Nuez
Human skin physiology changes during the course of life involving age-related changes in skin appearance. It has been suggested that eggshell membrane, a natural ingredient containing collagen, hyaluronic acid, elastine, among others, can be used for improving skin. However, there are limited clinical studies using eggshell membrane as a dietary supplement to study skin health. The efficacy of Ovoderm®, an oral supplement from eggshell membrane, on skin biophysical parameters related to cutaneous aging was evaluated.
{"title":"Supplementation with Ovoderm® Reduces the Clinical Signs of Skin Aging. A Double-Blind, Placebo-Controlled Study","authors":"A. Aguirre, E. Gil-Quintana, Manuel La Nuez","doi":"10.15226/2378-1726/5/2/00180","DOIUrl":"https://doi.org/10.15226/2378-1726/5/2/00180","url":null,"abstract":"Human skin physiology changes during the course of life involving age-related changes in skin appearance. It has been suggested that eggshell membrane, a natural ingredient containing collagen, hyaluronic acid, elastine, among others, can be used for improving skin. However, there are limited clinical studies using eggshell membrane as a dietary supplement to study skin health. The efficacy of Ovoderm®, an oral supplement from eggshell membrane, on skin biophysical parameters related to cutaneous aging was evaluated.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72821857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-25DOI: 10.15226/2378-1726/5/2/00179
Tsehai Seife, Alie Ayal, Mastewal Misganaw, F. T. Zewdu
Cutaneous leishmaniasis is one of the endemic and neglected diseases known to exist in Ethiopian highlands. However, a neglected tropical disease overshadowed by lack of effective anti-leishmaniasis agent in Ethiopia. Thus, high number of population is faced for various degree of socio-economical and psychosocial morbidity. Hence, this study was initiated and conducted from July-February, 2017/18 to assess the patterns and effectiveness of different types of anti-leishmaniasis agents in Boru Meda Hospital, Dessie District.
{"title":"Treatment Patterns, And Effectivness of Anti- Leishmaniasis Agents for Patients with Cutaneous Leishmaniasis at Boru Meda Hospital, South Wollo, North East Ethiopia, 2017/18","authors":"Tsehai Seife, Alie Ayal, Mastewal Misganaw, F. T. Zewdu","doi":"10.15226/2378-1726/5/2/00179","DOIUrl":"https://doi.org/10.15226/2378-1726/5/2/00179","url":null,"abstract":"Cutaneous leishmaniasis is one of the endemic and neglected diseases known to exist in Ethiopian highlands. However, a neglected tropical disease overshadowed by lack of effective anti-leishmaniasis agent in Ethiopia. Thus, high number of population is faced for various degree of socio-economical and psychosocial morbidity. Hence, this study was initiated and conducted from July-February, 2017/18 to assess the patterns and effectiveness of different types of anti-leishmaniasis agents in Boru Meda Hospital, Dessie District.","PeriodicalId":15481,"journal":{"name":"Journal of Clinical Research in Dermatology","volume":"64 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77601581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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