Pub Date : 2021-03-18DOI: 10.52142/OMUJECM.38.SI.GASTRO.13
U. Avcıoğlu, B. Baş, S. Çalişkan
Meckel’s diverticulum is the most common congenital anomaly of the gastrointestinal system. It results from the incomplete closure of the omphalomesenteric canal in intrauterine life. It is mostly diagnosed in childhood with intestinal obstruction and bleeding. It is uncommon and often clinically silent in adults. Also, it is difficult to diagnose the patients with symptomatic Meckel’s diverticulum. We report a 28-year-old male who presented with life-threatening recurrent lower gastrointestinal (GI) bleeding and was operated with the diagnosis of Meckel’s diverticulum with duodenal ulcer.
{"title":"A case of Meckel’s diverticulum with life-threatening recurrent gastrointestinal bleeding in an adult","authors":"U. Avcıoğlu, B. Baş, S. Çalişkan","doi":"10.52142/OMUJECM.38.SI.GASTRO.13","DOIUrl":"https://doi.org/10.52142/OMUJECM.38.SI.GASTRO.13","url":null,"abstract":"Meckel’s diverticulum is the most common congenital anomaly of the gastrointestinal system. It results from the incomplete closure of the omphalomesenteric canal in intrauterine life. It is mostly diagnosed in childhood with intestinal obstruction and bleeding. It is uncommon and often clinically silent in adults. Also, it is difficult to diagnose the patients with symptomatic Meckel’s diverticulum. We report a 28-year-old male who presented with life-threatening recurrent lower gastrointestinal (GI) bleeding and was operated with the diagnosis of Meckel’s diverticulum with duodenal ulcer.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"8 1","pages":"78-80"},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78537346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-18DOI: 10.52142/OMUJECM.38.SI.GASTRO.11
U. Avcıoğlu, A. İdil Soylu
It is difficult to diagnose Crohn's disease in the asymptomatic period. The aim of this study is to evaluate the diagnostic utility of CT enterography (CTE) in the diagnosis of asymptomatic Crohn's disease (CD) with small intestine involment in patients with iron deficiency anemia (IDA). 250 patients who underwent CTE examination between 2017 and 2018 were retrospectively scanned. 45 patients who had endoscopic examinations and diagnosed with IDA were included in the study. While one or more pathological findings to explain IDA were observed in 31 (68%) patients with endoscopic examinations, findings that could be explained as CD sequelae were observed in 4 (8.8%) patients. No lesions were observed by CTE in 10 (22.2%) patients. Diagnosis is difficult in mild forms of Crohn’s disease or in periods of remission. In this period, CTE can contribute to the diagnosis as it can also show extraluminal findings.
{"title":"Can asymptomatic Chron’s disease be diagnosed in patients with iron deficiency anemia by CT-enterograhpy?","authors":"U. Avcıoğlu, A. İdil Soylu","doi":"10.52142/OMUJECM.38.SI.GASTRO.11","DOIUrl":"https://doi.org/10.52142/OMUJECM.38.SI.GASTRO.11","url":null,"abstract":"It is difficult to diagnose Crohn's disease in the asymptomatic period. The aim of this study is to evaluate the diagnostic utility of CT enterography (CTE) in the diagnosis of asymptomatic Crohn's disease (CD) with small intestine involment in patients with iron deficiency anemia (IDA). 250 patients who underwent CTE examination between 2017 and 2018 were retrospectively scanned. 45 patients who had endoscopic examinations and diagnosed with IDA were included in the study. While one or more pathological findings to explain IDA were observed in 31 (68%) patients with endoscopic examinations, findings that could be explained as CD sequelae were observed in 4 (8.8%) patients. No lesions were observed by CTE in 10 (22.2%) patients. Diagnosis is difficult in mild forms of Crohn’s disease or in periods of remission. In this period, CTE can contribute to the diagnosis as it can also show extraluminal findings.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"8 1","pages":"71-73"},"PeriodicalIF":0.0,"publicationDate":"2021-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80421985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-14DOI: 10.52142/OMUJECM.38.2.10
N. A. Aslan, E. Kelkitli, N. Ozturk
Background Iron deficiency and zinc deficiency had been known to disturb congnitive functions especially in infants and preschool children. Our purpose was to evaluate the effect of zinc deficiency and iron deficiency on cognitive function (with Montreal Cognitive Assesment [MoCA] score) in females. Methods: We designed a randomized controlled prospective study. 41 iron deficient female patients and 40 healthy volunteers were involved in the study Results: The average MoCA score ± SD was 24,63 ± 4,3 (range 11–30) in iron deficiency anemia (IDA), and 27.43± 2.02 (23-30) in healthy volunteers. Zinc level was 97.06 (40.8–146.8) mg/dl and 257.5 (128.2–463.7) in IDA and healthy volunteers respectively. MoCA score (r= 0.803, p=0,000<0,01), were significantly correlated with Zinc Level in iron deficient group. Conclusion: We found that there was a statistically important linear relationship between MoCA score and zinc level in female patinets with iron defciency anemia.
{"title":"Effect of zinc deficiency on cognitive function in females with iron deficiency anemia","authors":"N. A. Aslan, E. Kelkitli, N. Ozturk","doi":"10.52142/OMUJECM.38.2.10","DOIUrl":"https://doi.org/10.52142/OMUJECM.38.2.10","url":null,"abstract":"Background Iron deficiency and zinc deficiency had been known to disturb congnitive functions especially in infants and preschool children. Our purpose was to evaluate the effect of zinc deficiency and iron deficiency on cognitive function (with Montreal Cognitive Assesment [MoCA] score) in females. Methods: We designed a randomized controlled prospective study. 41 iron deficient female patients and 40 healthy volunteers were involved in the study Results: The average MoCA score ± SD was 24,63 ± 4,3 (range 11–30) in iron deficiency anemia (IDA), and 27.43± 2.02 (23-30) in healthy volunteers. Zinc level was 97.06 (40.8–146.8) mg/dl and 257.5 (128.2–463.7) in IDA and healthy volunteers respectively. MoCA score (r= 0.803, p=0,000<0,01), were significantly correlated with Zinc Level in iron deficient group. Conclusion: We found that there was a statistically important linear relationship between MoCA score and zinc level in female patinets with iron defciency anemia.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"12 1","pages":"111-114"},"PeriodicalIF":0.0,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78554588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Şengül, Y. Büyükkarabacak, Gamze Altun, Z. Altunkaynak, Bilal Şengül, S. Gürz, A. Basoglu, M. G. Pirzirenli
Background: Surgical treatment of chest wall deformities is done with costal cartilage resection in selected patients in adolescence. In this study, we evaluated the effect of costal cartilage resections on the lung volume by using computed tomography with stereologically. Methods: In this study, sixteen 4-weeks-old New Zealand rabbits were employed. Young subjects were preferred to evaluate the effect of the operation on the growth process. In order to avoid postoperative complications, only 2 costal cartilage resection was performed. The surgical group was resected to the right 4 and 5 costal cartilages (n = 8). The group that was not operated was accepted as the control group (n=8). The growth of the subjects was followed. Computed thorax tomography (CTT) scans of all animals were performed preoperatively and at the 4th postoperative week. Estimation of pre- and postoperative lung volumes was performed with the Cavalieri principle. Results: In the control group followed up during growth, bilateral lung volume was increased (15.75% and 20.62% respectively right and left lungs). In the surgical group, both the surgical side and the opposite lung volume decreased after costal cartilage resection (20.09% and 1.07% respectively right and left lungs). Conclusions: Even though the number of resected cartilage was limited, total lung volume decreased after costal cartilage resection. In the treatment of chest wall deformities, costal cartilage resection should be considered as the last option in children.
{"title":"Does Costal Cartilage Resection Reduce Lung Volume ? (An Experimental Stereological Study)","authors":"A. Şengül, Y. Büyükkarabacak, Gamze Altun, Z. Altunkaynak, Bilal Şengül, S. Gürz, A. Basoglu, M. G. Pirzirenli","doi":"10.52142/OMUJECM.38.2.2","DOIUrl":"https://doi.org/10.52142/OMUJECM.38.2.2","url":null,"abstract":"Background: Surgical treatment of chest wall deformities is done with costal cartilage resection in selected patients in adolescence. In this study, we evaluated the effect of costal cartilage resections on the lung volume by using computed tomography with stereologically. Methods: In this study, sixteen 4-weeks-old New Zealand rabbits were employed. Young subjects were preferred to evaluate the effect of the operation on the growth process. In order to avoid postoperative complications, only 2 costal cartilage resection was performed. The surgical group was resected to the right 4 and 5 costal cartilages (n = 8). The group that was not operated was accepted as the control group (n=8). The growth of the subjects was followed. Computed thorax tomography (CTT) scans of all animals were performed preoperatively and at the 4th postoperative week. Estimation of pre- and postoperative lung volumes was performed with the Cavalieri principle. Results: In the control group followed up during growth, bilateral lung volume was increased (15.75% and 20.62% respectively right and left lungs). In the surgical group, both the surgical side and the opposite lung volume decreased after costal cartilage resection (20.09% and 1.07% respectively right and left lungs). Conclusions: Even though the number of resected cartilage was limited, total lung volume decreased after costal cartilage resection. In the treatment of chest wall deformities, costal cartilage resection should be considered as the last option in children.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"44 1","pages":"61-65"},"PeriodicalIF":0.0,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91231456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim/Background Traumatic atlantoaxial instability usually results from a motor vehicle accident, falls and motorcycle accidents. Atlantoaxial instability can lead to spinal cord compression and neck pain, but, spasticity and radicular symptoms as well. The purpose of surgery is to remove the compression and stabilize the joint permanently. To date, several surgical techniques have been described to remedy C1-C2 instability. In this study, the clinical and radiological outcomes of patients who operated with the C1 (Atlas bone) laminar hooks fixation and bilateral C2 (Axis bone) trans-pedicular screw technique were shown. Also, the advantages and disadvantages of this technique are discussed. Methods From March 2010 to December 2017, 12 patients who have atlantoaxial instability were surgically treated by modified fixation technique which consists C1 laminar hooks fixation and bilateral C2 transpedicular screw. Results Twelve patients were operated with this procedure from March 2010 to December 2017. All the patients were checked with flexion-extension x-rays at the end of the twelfth week. The posterior bony fusion formation was observed on imaging in all patients. Conclusion C2 bilateral pedicle screw combined with C1 laminar hook system is a good method for atlantoaxial instability in the conditions which is not convenient for insertion of C1 lateral mass and C2 trans-articular screw. However, this method may not be available in some cases such as traumatic, infection, neoplastic or degenerative pathologies in which the posterior arch of the atlas is damaged.
{"title":"The application of C2 transpedicular screw, C1 laminar hook fixation and bone graft in the atlantoaxial instability","authors":"Sukru Oral","doi":"10.52142/OMUJECM.38.2.7","DOIUrl":"https://doi.org/10.52142/OMUJECM.38.2.7","url":null,"abstract":"Aim/Background Traumatic atlantoaxial instability usually results from a motor vehicle accident, falls and motorcycle accidents. Atlantoaxial instability can lead to spinal cord compression and neck pain, but, spasticity and radicular symptoms as well. The purpose of surgery is to remove the compression and stabilize the joint permanently. To date, several surgical techniques have been described to remedy C1-C2 instability. In this study, the clinical and radiological outcomes of patients who operated with the C1 (Atlas bone) laminar hooks fixation and bilateral C2 (Axis bone) trans-pedicular screw technique were shown. Also, the advantages and disadvantages of this technique are discussed. Methods From March 2010 to December 2017, 12 patients who have atlantoaxial instability were surgically treated by modified fixation technique which consists C1 laminar hooks fixation and bilateral C2 transpedicular screw. Results Twelve patients were operated with this procedure from March 2010 to December 2017. All the patients were checked with flexion-extension x-rays at the end of the twelfth week. The posterior bony fusion formation was observed on imaging in all patients. Conclusion C2 bilateral pedicle screw combined with C1 laminar hook system is a good method for atlantoaxial instability in the conditions which is not convenient for insertion of C1 lateral mass and C2 trans-articular screw. However, this method may not be available in some cases such as traumatic, infection, neoplastic or degenerative pathologies in which the posterior arch of the atlas is damaged.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"131 1","pages":"94-98"},"PeriodicalIF":0.0,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78517449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-14DOI: 10.52142/OMUJECM.38.2.23
Vahid Hamidi Omran, M. Ranaei, N. Neamati, J. Shirvani, K. Tilaki, A. Mosapour, Mehdi Soltanzadeh Yamchi, M. Tourani, H. Parsian
Background: Helicobacter pylori (H. pylori) infection can result in various complications, included micronutrient variations, nutritional impairment, gastric tissue damages and oxidative stress. The present study aimed to evaluate serum variations of Cu and Se in H. pylori infected individuals. Materials and methods: A prospective case-control study was performed on 69 participants with abdominal pains (40 patients with H. pylori gastritis versus 29 control group). Serum levels of Cu and Se were measured using Atomic Absorption Spectrophotometer. Statistical analysis was performed using SPSS software. Comparisons of elements between included groups were done using independent sample t-test. Subgroup analysis between male and female (with or without H. pylori) was performed using one way analysis of variance. Correlation between serum Cu and Se was assessed using Pearson’s correlation test. The p-value levels less than 0.05 were considered as significant. Results: There were no significant differences in serum levels of Cu and Se between H. pylori positive and negative persons. In male with H. pylori, Se levels were 38.4% higher than control male (p-value=0.03). A positive and significant correlation was observed between serum Cu and Se levels (r = 0.51, P-value = 0.024). Conclusion: Although no statistic difference was observed in serum Cu and Se levels, the significant correlation between measured elements represent as good evidence for some discrepancies. Given the importance of well controlled micronutrients in whole body health, especially in high risk H. pylori patients, more studies are needed to clarify the exact relation of these and other trace elements with H. pylori outcomes.
{"title":"Evaluation of serum levels of copper and selenium in Helicobacter pylori positive and negative gastritis patients","authors":"Vahid Hamidi Omran, M. Ranaei, N. Neamati, J. Shirvani, K. Tilaki, A. Mosapour, Mehdi Soltanzadeh Yamchi, M. Tourani, H. Parsian","doi":"10.52142/OMUJECM.38.2.23","DOIUrl":"https://doi.org/10.52142/OMUJECM.38.2.23","url":null,"abstract":"Background: Helicobacter pylori (H. pylori) infection can result in various complications, included micronutrient variations, nutritional impairment, gastric tissue damages and oxidative stress. The present study aimed to evaluate serum variations of Cu and Se in H. pylori infected individuals. Materials and methods: A prospective case-control study was performed on 69 participants with abdominal pains (40 patients with H. pylori gastritis versus 29 control group). Serum levels of Cu and Se were measured using Atomic Absorption Spectrophotometer. Statistical analysis was performed using SPSS software. Comparisons of elements between included groups were done using independent sample t-test. Subgroup analysis between male and female (with or without H. pylori) was performed using one way analysis of variance. Correlation between serum Cu and Se was assessed using Pearson’s correlation test. The p-value levels less than 0.05 were considered as significant. Results: There were no significant differences in serum levels of Cu and Se between H. pylori positive and negative persons. In male with H. pylori, Se levels were 38.4% higher than control male (p-value=0.03). A positive and significant correlation was observed between serum Cu and Se levels (r = 0.51, P-value = 0.024). Conclusion: Although no statistic difference was observed in serum Cu and Se levels, the significant correlation between measured elements represent as good evidence for some discrepancies. Given the importance of well controlled micronutrients in whole body health, especially in high risk H. pylori patients, more studies are needed to clarify the exact relation of these and other trace elements with H. pylori outcomes.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"73 1","pages":"182-186"},"PeriodicalIF":0.0,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80575860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-14DOI: 10.52142/OMUJECM.38.2.16
Banuhan Şahin, D. Öztürk
Objective: The aim of this study is to investigate the level of anxiety and distress among pregnant women during the outbreak of Covid-19. Material and Methods: A 30-item questionnaire was applied on-line to a total of 240 pregnant women from all the cities of Turkey between 18-24 May 2020. With this questionnaire, demographic data of the participants, their knowledge and concerns about Covid-19, general measures they took against Covid-19, pregnancy follow-ups and their delivery preferences were evaluated. In addition, the State-trait Anxiety Inventory (STAI) adapted to Turkish was applied to each participant. Personal and obstetric information were grouped and compared with the anxiety scale. Anxiety levels of the groups were calculated. Results: The STAI score means of 240 pregnant women who filled our questionnaire was 46.39±12.36 and the Cronbach Alpha value was calculated as 0.93. It was found that 125 pregnant women received help by contacting their doctor over the phone during the Covid-19 outbreak. It was also found that 106 pregnant women wanted to give birth at home. It was again found that 47.9% of pregnant women received information about Covid-19 from television. The STAI scores of pregnant women whose one or more family members’ Covid-19 test were positive was 59.60 ± 5.63. The anxiety scores of pregnant women who were healthcare workers was 48.30 ± 12.27. Conclusions: Necessary clinical and psychological counseling services should be provided by local and national health institutions via television, telephone and internet for pregnant women, whose anxiety level increased during the Covid-19 outbreak, to be in full physical and mental well-being.
{"title":"Evaluation of the level of anxiety among pregnant women during the outbreak of Covid-19","authors":"Banuhan Şahin, D. Öztürk","doi":"10.52142/OMUJECM.38.2.16","DOIUrl":"https://doi.org/10.52142/OMUJECM.38.2.16","url":null,"abstract":"Objective: The aim of this study is to investigate the level of anxiety and distress among pregnant women during the outbreak of Covid-19. Material and Methods: A 30-item questionnaire was applied on-line to a total of 240 pregnant women from all the cities of Turkey between 18-24 May 2020. With this questionnaire, demographic data of the participants, their knowledge and concerns about Covid-19, general measures they took against Covid-19, pregnancy follow-ups and their delivery preferences were evaluated. In addition, the State-trait Anxiety Inventory (STAI) adapted to Turkish was applied to each participant. Personal and obstetric information were grouped and compared with the anxiety scale. Anxiety levels of the groups were calculated. Results: The STAI score means of 240 pregnant women who filled our questionnaire was 46.39±12.36 and the Cronbach Alpha value was calculated as 0.93. It was found that 125 pregnant women received help by contacting their doctor over the phone during the Covid-19 outbreak. It was also found that 106 pregnant women wanted to give birth at home. It was again found that 47.9% of pregnant women received information about Covid-19 from television. The STAI scores of pregnant women whose one or more family members’ Covid-19 test were positive was 59.60 ± 5.63. The anxiety scores of pregnant women who were healthcare workers was 48.30 ± 12.27. Conclusions: Necessary clinical and psychological counseling services should be provided by local and national health institutions via television, telephone and internet for pregnant women, whose anxiety level increased during the Covid-19 outbreak, to be in full physical and mental well-being.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"57 1","pages":"143-149"},"PeriodicalIF":0.0,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76076330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Sadeghinezhad, Moslem Dahmardeh, Z. Tootian, Hadis Bojarzadeh, F. Yarmahmoudi
Oxaliplatin (Ox) is widely used for the treatment of various tumors. Since Ox prevents DNA replication and transcription, it may affect organs with rapid cell divisions such as the testes. Although its use during pregnancy has been reported, no information regarding its effects on the testes of the offspring is not available yet. Thirty-two mice were randomly divided into four groups. The control group (1) was administered intraperitoneally 0.2 ml of saline three times a week for the 21 days of pre-pregnancy, pregnancy and lactation. Experimental groups 2, 3 and 4 received 3 mg/kg of oxaliplatin three times a week for 21 days during pre-pregnancy, pregnancy and lactation, respectively. The left testis was removed from male offspring 30 and 60 days after birth. The volume of the testes, seminiferous tubules and interstitial tissue, the surface area and height of the seminiferous epithelium, as well as the length and diameter of seminiferous tubules, were analyzed by means of stereology. Results showed a decrease in the evaluated parameters in experimental groups, in comparison with the control group. Due to the ameliorating effect of Ox on offspring testes, cautiousness is needed during maternal administration in order to preserve the fertility of male offspring.
{"title":"Study on the effect of maternal administration of oxaliplatin on offspring testes using unbiased design-based stereology","authors":"J. Sadeghinezhad, Moslem Dahmardeh, Z. Tootian, Hadis Bojarzadeh, F. Yarmahmoudi","doi":"10.52142/OMUJECM.38.2.8","DOIUrl":"https://doi.org/10.52142/OMUJECM.38.2.8","url":null,"abstract":"Oxaliplatin (Ox) is widely used for the treatment of various tumors. Since Ox prevents DNA replication and transcription, it may affect organs with rapid cell divisions such as the testes. Although its use during pregnancy has been reported, no information regarding its effects on the testes of the offspring is not available yet. Thirty-two mice were randomly divided into four groups. The control group (1) was administered intraperitoneally 0.2 ml of saline three times a week for the 21 days of pre-pregnancy, pregnancy and lactation. Experimental groups 2, 3 and 4 received 3 mg/kg of oxaliplatin three times a week for 21 days during pre-pregnancy, pregnancy and lactation, respectively. The left testis was removed from male offspring 30 and 60 days after birth. The volume of the testes, seminiferous tubules and interstitial tissue, the surface area and height of the seminiferous epithelium, as well as the length and diameter of seminiferous tubules, were analyzed by means of stereology. Results showed a decrease in the evaluated parameters in experimental groups, in comparison with the control group. Due to the ameliorating effect of Ox on offspring testes, cautiousness is needed during maternal administration in order to preserve the fertility of male offspring.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"3 1","pages":"99-106"},"PeriodicalIF":0.0,"publicationDate":"2021-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81903121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-01DOI: 10.5835/JECM.OMU.38.01.007
Ozlem Kazan Kizilkurt, Gürler Güz, H. Güz, N. Dilbaz
Novel Coronavirus (COVID-19) pandemic which is a global public health problem continues to affect humans both physically and psychologically all around the world. So, it is important to diagnose and manage the anxiety while fighting the COVID-19 pandemic. The present study aimed to separately evaluate state and trait anxiety in the COVID-19 pandemic in Turkey. In addition, it was aimed to investigate the relation of demographic variable with state anxiety in the COVID-19 pandemic, as well as the relationship between trait anxiety and somatosensory amplification with state anxiety.726 participants who responded to online survey between March 30th and April 20th, 2020 were evaluated. All participants answered the survey that covered sociodemographic data and questions specifically about COVID-19 pandemic as well as State-Trait Anxiety Inventory and Somatosensory Amplification Scale. Pearson test was used for correlation analysis, ordinal variables were analyzed with Spearman correlation test. State anxiety is higher, if the participant is woman, has an acquaintance with the COVID-19 positivity, has a chronic medical condition and currently receiving or has history of psychiatric treatment. Age, monthly income, trait anxiety level and somatosensory amplification are also factors related to state anxiety. In conclusion, it is considered that those populations may be more vulnerable to the psychological effects of pandemic and they should be closely followed up for longer periods.
{"title":"State-trait anxiety levels in Turkey during COVID-19 pandemic and its relationship to somatosensory amplification","authors":"Ozlem Kazan Kizilkurt, Gürler Güz, H. Güz, N. Dilbaz","doi":"10.5835/JECM.OMU.38.01.007","DOIUrl":"https://doi.org/10.5835/JECM.OMU.38.01.007","url":null,"abstract":"Novel Coronavirus (COVID-19) pandemic which is a global public health problem continues to affect humans both physically and psychologically all around the world. So, it is important to diagnose and manage the anxiety while fighting the COVID-19 pandemic. The present study aimed to separately evaluate state and trait anxiety in the COVID-19 pandemic in Turkey. In addition, it was aimed to investigate the relation of demographic variable with state anxiety in the COVID-19 pandemic, as well as the relationship between trait anxiety and somatosensory amplification with state anxiety.726 participants who responded to online survey between March 30th and April 20th, 2020 were evaluated. All participants answered the survey that covered sociodemographic data and questions specifically about COVID-19 pandemic as well as State-Trait Anxiety Inventory and Somatosensory Amplification Scale. Pearson test was used for correlation analysis, ordinal variables were analyzed with Spearman correlation test. State anxiety is higher, if the participant is woman, has an acquaintance with the COVID-19 positivity, has a chronic medical condition and currently receiving or has history of psychiatric treatment. Age, monthly income, trait anxiety level and somatosensory amplification are also factors related to state anxiety. In conclusion, it is considered that those populations may be more vulnerable to the psychological effects of pandemic and they should be closely followed up for longer periods.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"41 1","pages":"33-38"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87097213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-28DOI: 10.21203/rs.3.rs-134810/v1
T. Yildirim, Ali Yilmaz, S. Köktürk, H. Işık
Aim:We aimed to compare the effectiveness of curcumin, which has been shown to inhibit cell migration and proliferation, with that of methylprednisolone, which has been shown to have a similar mechanism of action to that of curcumin and to delay tissue repair and wound healing, in the prevention of epidural fibrosis in an experimental laminectomy model in rats.Material and methods:The experiment was conducted with 40 male Wistar rats weighing 250-300 g which were divided into four groups. Laminectomy was performed from L1 to L4 in all groups. Curcumin and methylprednisolone were applied to the other two groups except the control and Dmso groups. The vertebral colon was excised en bloc and each section was examined for epidural fibrosis formation under a light microscope to evaluate histologically using the grading system.Results:The statistical analyses indicated that the treatment groups had a significant effect on the histological grades of epidural fibrosis in rats compared to the control group.Discussion:Curcumin, derived from the rhizome (Rhizoma Curcumae) of turmeric (Curcuma longa) was found to show a significant effect in the prevention of epidural fibrosis formation with its potent antioxidant and anti-inflammatory properties and by inhibiting further recruitment of fibroblasts to the laminectomy area.Conclusions:In the present study, both histological examination and statistical analyses indicated that the administration of curcumin led to a remarkable reduction in epidural fibrosis after laminectomy.
{"title":"Comparison of Curcumin and Methylprednisolone in Preventing Epidural Fibrosis After Spinal Surgery: An Experimental Study","authors":"T. Yildirim, Ali Yilmaz, S. Köktürk, H. Işık","doi":"10.21203/rs.3.rs-134810/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-134810/v1","url":null,"abstract":"\u0000 Aim:We aimed to compare the effectiveness of curcumin, which has been shown to inhibit cell migration and proliferation, with that of methylprednisolone, which has been shown to have a similar mechanism of action to that of curcumin and to delay tissue repair and wound healing, in the prevention of epidural fibrosis in an experimental laminectomy model in rats.Material and methods:The experiment was conducted with 40 male Wistar rats weighing 250-300 g which were divided into four groups. Laminectomy was performed from L1 to L4 in all groups. Curcumin and methylprednisolone were applied to the other two groups except the control and Dmso groups. The vertebral colon was excised en bloc and each section was examined for epidural fibrosis formation under a light microscope to evaluate histologically using the grading system.Results:The statistical analyses indicated that the treatment groups had a significant effect on the histological grades of epidural fibrosis in rats compared to the control group.Discussion:Curcumin, derived from the rhizome (Rhizoma Curcumae) of turmeric (Curcuma longa) was found to show a significant effect in the prevention of epidural fibrosis formation with its potent antioxidant and anti-inflammatory properties and by inhibiting further recruitment of fibroblasts to the laminectomy area.Conclusions:In the present study, both histological examination and statistical analyses indicated that the administration of curcumin led to a remarkable reduction in epidural fibrosis after laminectomy.","PeriodicalId":15770,"journal":{"name":"Journal of Experimental & Clinical Medicine","volume":"57 1","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80119576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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