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The association of locomotive and non-locomotive physical activity measured by an accelerometer with functional fitness in healthy elderly men: a pilot study. 用加速度计测量健康老年男性的运动性和非运动性体力活动与功能性体能的关系:一项试点研究。
Pub Date : 2018-03-30 DOI: 10.20463/jenb.2018.0007
Hyejoon Park, Wonil Park, Moran Lee, Nayoung Ko, Eunkyung Kim, Kazuko Ishikawa-Takata, Jonghoon Park

Purpose: The purpose of this study was to investigate the relationship of various aspects of daily physical activity, such as the number of steps, time spent in moderate to vigorous intensity physical activity (MVPA), and locomotive and non-locomotive MVPA measured by a triaxial accelerometer, with the functional fitness in healthy elderly men.

Methods: The subjects of this study were 22 healthy elderly men aged over 65 years. The participants wore a triaxial accelerometer for two weeks to estimate their daily physical activities. The level of functional fitness was measured based on "National Fitness Award 100 in Korea" immediately after the measurement of two weeks of daily physical activities.

Results: The results showed that active healthy elderly men with more than 6,500 walking steps per day and more than 60 min per day spent in MVPA showed a significantly higher 2-min marching in place and index of cardiorespiratory endurance compared to less physically active participants. Particularly, locomotive MVPA was significantly associated with cardiorespiratory endurance levels (r = 0.50), whereas non-locomotive MVPA was not associated with other measurements of functional fitness.

Conclusion: Increased MVPA time, especially the locomotive MVPA, can effectively suppress the decrease in cardiorespiratory endurance level in elderly men. However, no association was observed between non-locomotive MVPA, such as household activities, and functional fitness in healthy elderly men.

目的:本研究的目的是调查健康老年男性日常体力活动的各个方面(如步数、中等至剧烈强度体力活动(MVPA)所花费的时间、由三轴加速度计测量的运动性和非运动性 MVPA)与功能性体能之间的关系:研究对象为 22 名 65 岁以上的健康老年男性。参与者佩戴三轴加速度计两周,以估算他们的日常体力活动。在测量两周的日常体力活动后,立即根据 "韩国国民体质100奖 "测量功能性体能水平:结果表明,与体力活动较少的参与者相比,每天步行超过 6500 步、每天 MVPA 时间超过 60 分钟的活跃健康老年男性的 2 分钟原地踏步和心肺耐力指数明显更高。特别是,运动型 MVPA 与心肺耐力水平显著相关(r = 0.50),而非运动型 MVPA 与其他功能性体能测量结果无关:结论:增加 MVPA 时间,尤其是机动力 MVPA,可有效抑制老年男性心肺耐力水平的下降。结论:增加 MVPA 时间,尤其是机动力 MVPA 时间,可有效抑制老年男性心肺耐力水平的下降,但在健康老年男性中,非机动力 MVPA(如家务活动)与功能性体能之间没有关联。
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引用次数: 0
Arc/Arg3.1 protein expression in dorsal hippocampal CA1, a candidate event as a biomarker for the effects of exercise on chronic stress-evoked behavioral abnormalities. Arc/Arg3.1蛋白在海马背侧CA1中的表达,作为运动对慢性应激性行为异常影响的候选生物标志物。
Pub Date : 2017-12-31 DOI: 10.20463/jenb.2017.0033
Yea-Hyun Leem, Hyukki Chang

Purpose: Chronic stress is a risk factor for behavioral deficits, including impaired memory processing and depression. Exercise is well known to have beneficial impacts on brain health.

Methods: Mice were forced to treadmill running (4-week) during chronic restraint stress (6h/21d), and then behavioral tests were conducted by Novel object recognition, forced swimming test: FST, sociality test: SI. Dissected brain was stained with anti-calbindin-d28k and anti-Arc antibodies. Also, mice were treated with CX546 intraperitoneally during chronic restraint stress, and behavioral tests were assessed using Morris water maze, FST, and SI. Dissected brain was stained with anti-Arc antibody.

Results: The current study demonstrated that chronic stress-induced impairment of memory consolidation and depression-like behaviors, along with the changes in calbindin-d28k and Arc protein levels in the hippocampal CA1 area, were attenuated by regular treadmill running. Further, prolonged ampakine treatment prevented chronic stress-evoked behavioral abnormalities and nuclear Arc levels in hippocampal CA1 neurons. Nuclear localization of Arc protein in hippocampal CA1 neurons, but not total levels, was correlated with behavioral outcome in chronically stressed mice in response to a regular exercise regimen.

Conclusion: These results suggest that nuclear levels of Arc are strongly associated with behavioral changes, and highlight the role of exercise acting through an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPAR)-mediated mechanisms in a chronic stress-induced maladaptive condition.

目的:慢性压力是行为缺陷的危险因素,包括记忆处理受损和抑郁。众所周知,锻炼对大脑健康有益。方法:在慢性约束应激(6h/21d)条件下,强迫小鼠在跑步机上跑步(4周),进行新物体识别、强迫游泳测试(FST)、社会性测试(SI)等行为测试。用抗calbinin -d28k和抗arc抗体对解剖脑组织进行染色。此外,小鼠在慢性约束应激期间腹腔注射CX546,并使用Morris水迷宫、FST和SI评估行为测试。解剖脑组织进行抗arc抗体染色。结果:目前的研究表明,长期的应激导致的记忆巩固和抑郁样行为的损害,以及海马CA1区calbinding -d28k和Arc蛋白水平的变化,通过定期的跑步机运动而减弱。此外,长期的安帕平治疗可以预防慢性应激引起的行为异常和海马CA1神经元的核弧水平。长期应激小鼠对常规运动方案的反应中,海马CA1神经元中Arc蛋白的核定位与行为结果相关,而不是总水平。结论:这些结果表明Arc的核水平与行为改变密切相关,并强调运动在慢性应激诱导的适应不良状态中通过α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体(AMPA)介导的机制起作用。
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引用次数: 7
Nutritional needs in the professional practice of swimming: a review. 游泳专业实践中的营养需求:综述。
Pub Date : 2017-12-31 DOI: 10.20463/jenb.2017.0030
Raúl Domínguez, Antonio Jesús-Sánchez-Oliver, Eduardo Cuenca, Pablo Jodra, Sandro Fernandes da Silva, Fernando Mata-Ordóñez

Purpose: Swimming requires developing a high aerobic and anaerobic capacity for strength and technical efficiency. The purpose of this study was to establish the nutritional requirements and dietary strategies that can optimize swimming performance.

Methods: Several related studies retrieved from the databases, Dialnet, Elsevier, Medline, Pubmed, and Web of Science, through keyword search strategies were reviewed.

Results: The recommended carbohydrate intake ranges between 6-10-12 g/kg/d, protein 2 g/kg/d, and fat should surpass 20-25% of the daily intake.

Conclusion: Performance can be optimized with a hydration plan, as well as adequate periodization of supplements, such as caffeine, creatine, sodium bicarbonate, B-alanine, beetroot juice, Vitamin D, bovine colostrum, and HMB.

目的:游泳需要发展一个高有氧和无氧能力的力量和技术效率。本研究的目的是建立营养需求和饮食策略,以优化游泳成绩。方法:采用关键词搜索策略,对从Dialnet、Elsevier、Medline、Pubmed、Web of Science等数据库中检索到的相关研究进行综述。结果:建议碳水化合物摄入量为6-10-12 g/kg/d,蛋白质摄入量为2 g/kg/d,脂肪应超过日摄入量的20-25%。结论:通过制定补水计划以及适当的定期补充,如咖啡因、肌酸、碳酸氢钠、b -丙氨酸、甜菜根汁、维生素D、牛初乳和HMB,可以优化运动性能。
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引用次数: 15
Weight reduction does not induce an undesirable decrease in muscle mass, muscle strength, or physical performance in men with obesity: a pilot study. 减轻体重不会导致肥胖男性的肌肉质量、肌肉力量或体能下降:一项试点研究。
Pub Date : 2017-12-31 DOI: 10.20463/jenb.2017.0029
Bokun Kim, Takehiko Tsujimoto, Rina So, Xiaoguang Zhao, Sechang Oh, Kiyoji Tanaka

Purpose: To date, there have been no reports on whether weight reduction causes decreases in muscle mass, muscle strength, or physical performance that could lead to health problems. Thus, in this pilot study, we investigated the appropriateness of the changes in muscle mass, muscle strength and physical performance after weight reduction.

Methods: Obese men who completed a weight reduction program to decrease and maintain a body mass index (BMI) of less than 25 kg/m2 for one year were recruited for the study. One year after the completion of a weight reduction program, the participants' muscle mass, muscle strength, and physical performance were compared with those in a reference group composed of individuals whose BMI was less than 25 kg/m2. Whole-body scanning was performed using dual-energy X-ray absorptiometry to analyze muscle mass. Handgrip strength and knee extensor strength were measured to evaluate arm and leg muscle strength, respectively. For physical performance, a jump test was employed.

Results: The results showed that the biceps, triceps, subscapular, and suprailiac areas of professional fashion models were significantly thinner than those of women in general (p<.001), and that their waist size was also significantly smaller (p<.001). However, hip circumference showed no significant difference. Body mass index, waist-to-hip ratio, and body fat (%) in professional fashion models were significantly lower than those in women in general (p<.001), while the body density in professional fashion models was significantly greater (p<0.001).

Conclusion: Weight reduction participants showed an average reduction in body weight of -16.47%. Normalized arm muscle mass and handgrip strength were significantly greater in the weight reduction group than in the reference group; however, no significant differences were detected between the two groups with respect to the other variables. After one year, there were no significant differences between the two groups.

目的:迄今为止,还没有关于减轻体重是否会导致肌肉质量、肌肉力量或体能下降,从而引发健康问题的报道。因此,在这项试验性研究中,我们调查了减重后肌肉质量、肌肉力量和体能变化的适当性:研究招募了完成减重计划,将体重指数(BMI)降低并维持在 25 kg/m2 以下一年的肥胖男性。在完成减重计划一年后,将参与者的肌肉质量、肌肉力量和体能表现与由体重指数低于 25 kg/m2 的人组成的参照组进行比较。采用双能 X 射线吸收仪进行全身扫描,分析肌肉质量。测量手握力和膝关节伸展力分别是为了评估手臂和腿部肌肉力量。在体能方面,采用了跳跃测试:结果显示,职业时装模特的肱二头肌、肱三头肌、肩胛下和髂上部位明显比普通女性瘦(p):减重参与者的体重平均减少了 -16.47%。减重组的正常化手臂肌肉质量和握力明显高于参照组;但在其他变量方面,两组之间没有发现明显差异。一年后,两组之间没有明显差异。
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引用次数: 0
The potential role of exercise in chronic stress-related changes in AMPA receptor phenotype underlying synaptic plasticity. 运动在慢性应激相关的突触可塑性下AMPA受体表型变化中的潜在作用。
Pub Date : 2017-12-31 DOI: 10.20463/jenb.2017.0037
Yea-Hyun Leem
[Purpose] Chronic stress can cause disturbances in synaptic plasticity, such as longterm potentiation, along with behavioral defects including memory deficits. One major mechanism sustaining synaptic plasticity involves the dynamics and contents of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) in the central nervous system. In particular, chronic stress-induced disruption of AMPARs includes it abnormal expression, trafficking, and calcium conductance at glutamatergic synapses, which contributes to synaptic plasticity at excitatory synapses. Exercise has the effect of promoting synaptic plasticity in neurons. However, the contribution of exercise to AMPAR behavior under chronic stressful maladaptation remains unclear. [Methods] The present article reviews the information about the chronic stress-related synaptic plasticity and the role of exercise from the previous-published articles. [Results] AMPAR-mediated synaptic transmission is an important for chronic stress-related changes of synaptic plasticity, and exercise may at least partly contribute to these episodes. [Conclusion] The present article discusses the relationship between AMPARs and synaptic plasticity in chronic stress, as well as the potential role of exercise.
目的:慢性应激可引起突触可塑性紊乱,如长时程增强,以及包括记忆缺陷在内的行为缺陷。中枢神经系统中α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体(AMPARs)的动态和含量是维持突触可塑性的主要机制之一。特别是,慢性应激诱导的AMPARs破坏包括谷氨酸能突触的异常表达、运输和钙传导,这有助于兴奋性突触的突触可塑性。运动有促进神经元突触可塑性的作用。然而,在慢性应激性不适应下,运动对AMPAR行为的影响尚不清楚。方法:回顾前人关于慢性应激相关突触可塑性和运动在其中的作用。结果:ampar介导的突触传递在慢性应激相关的突触可塑性变化中起重要作用,而运动可能至少在一定程度上促进了这些变化。结论:本文讨论了慢性应激下AMPARs与突触可塑性的关系,以及运动的潜在作用。
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引用次数: 5
The role of habitual physical activity on arterial stiffness in elderly Individuals: a systematic review and meta-analysis. 习惯性体育活动对老年人动脉硬化的作用:一项系统综述和荟萃分析。
Pub Date : 2017-12-31 DOI: 10.20463/jenb.2017.0041
Wonil Park, Hun-Young Park, Kiwon Lim, Jonghoon Park

Purpose: Physical inactivity behavior at middle age or older is a major risk factor for cardiovascular disease. However, the effects of levels of habitual physical activity on arterial stiffness in elderly population remain unclear currently. Therefore, the purpose of this study was to demonstrate whether the effects of habitual physical activity could attenuate arterial stiffness in elderly individuals via a meta-analysis.

Methods: We searched the Medline and Embase databases from January 1997 through November 2017, using the medical subject headings "older population", "physical activity" (e.g., walking, cycling, climbing, and any participation in sports), "arterial stiffness", "pulse wave velocity", and "cardiovascular health" published in English. Six articles (2,932 participants) were included in this meta-analysis. We investigated the effects of habitual physical activity on arterial stiffness, which was measured by the pulse wave velocity.

Results: Results confirmed heterogeneity (Q-value = 160.691, p = 0.000, I2 = 96.888) between individual studies. The effect size was calculated using random effect model. It has shown that physically active individuals have significantly lower arterial stiffness than their sedentary peers do (standardized mean difference: -1.017 ± 0.340, 95% confidence interval: -1.684 ~ -0.350, p = 0.003).

Conclusion: Findings of our systematic review and meta-analysis indicate that habitual physical activity can significantly ameliorate arterial stiffness in the elderly population.

目的:中老年缺乏身体活动是心血管疾病的主要危险因素。然而,目前尚不清楚习惯体育活动水平对老年人动脉硬化的影响。因此,本研究的目的是通过荟萃分析来证明习惯性体育活动是否可以减轻老年人动脉僵硬的影响。方法:我们检索了1997年1月至2017年11月的Medline和Embase数据库,使用英文出版的医学主题标题为“老年人口”、“身体活动”(例如步行、骑自行车、登山和任何体育运动)、“动脉僵硬度”、“脉搏波速度”和“心血管健康”。6篇文章(2,932名参与者)被纳入本荟萃分析。我们研究了习惯性体育活动对动脉硬度的影响,这是通过脉搏波速度来测量的。结果:结果证实各研究之间存在异质性(q值= 160.691,p = 0.000, I2 = 96.888)。效应量采用随机效应模型计算。研究表明,经常运动的人动脉僵硬度明显低于不运动的同龄人(标准化平均差:-1.017±0.340,95%可信区间:-1.684 ~ -0.350,p = 0.003)。结论:我们的系统综述和荟萃分析的结果表明,习惯性体育活动可以显著改善老年人的动脉僵硬。
{"title":"The role of habitual physical activity on arterial stiffness in elderly Individuals: a systematic review and meta-analysis.","authors":"Wonil Park,&nbsp;Hun-Young Park,&nbsp;Kiwon Lim,&nbsp;Jonghoon Park","doi":"10.20463/jenb.2017.0041","DOIUrl":"https://doi.org/10.20463/jenb.2017.0041","url":null,"abstract":"<p><strong>Purpose: </strong>Physical inactivity behavior at middle age or older is a major risk factor for cardiovascular disease. However, the effects of levels of habitual physical activity on arterial stiffness in elderly population remain unclear currently. Therefore, the purpose of this study was to demonstrate whether the effects of habitual physical activity could attenuate arterial stiffness in elderly individuals via a meta-analysis.</p><p><strong>Methods: </strong>We searched the Medline and Embase databases from January 1997 through November 2017, using the medical subject headings \"older population\", \"physical activity\" (e.g., walking, cycling, climbing, and any participation in sports), \"arterial stiffness\", \"pulse wave velocity\", and \"cardiovascular health\" published in English. Six articles (2,932 participants) were included in this meta-analysis. We investigated the effects of habitual physical activity on arterial stiffness, which was measured by the pulse wave velocity.</p><p><strong>Results: </strong>Results confirmed heterogeneity (Q-value = 160.691, p = 0.000, I2 = 96.888) between individual studies. The effect size was calculated using random effect model. It has shown that physically active individuals have significantly lower arterial stiffness than their sedentary peers do (standardized mean difference: -1.017 ± 0.340, 95% confidence interval: -1.684 ~ -0.350, p = 0.003).</p><p><strong>Conclusion: </strong>Findings of our systematic review and meta-analysis indicate that habitual physical activity can significantly ameliorate arterial stiffness in the elderly population.</p>","PeriodicalId":15795,"journal":{"name":"Journal of Exercise Nutrition & Biochemistry","volume":"21 4","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2017-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35768531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Comparison of body composition between fashion models and women in general. 时装模特与普通女性身体成分的比较。
Pub Date : 2017-12-31 DOI: 10.20463/jenb.2017.0032
Sunhee Park

Purpose: The present study compared the physical characteristics and body composition of professional fashion models and women in general, utilizing the skinfold test.

Methods: The research sample consisted of 90 professional fashion models presently active in Korea and 100 females in the general population, all selected through convenience sampling. Measurement was done following standardized methods and procedures set by the International Society for the Advancement of Kinanthropometry. Body density (mg/ mm) and body fat (%) were measured at the biceps, triceps, subscapular, and suprailiac areas.

Results: The results showed that the biceps, triceps, subscapular, and suprailiac areas of professional fashion models were significantly thinner than those of women in general (p<.001), and that their waist size was also significantly smaller (p<.001). However, hip circumference showed no significant difference. Body mass index, waist-to-hip ratio, and body fat (%) in professional fashion models were significantly lower than those in women in general (p<.001), while the body density in professional fashion models was significantly greater (p<.001).

Conclusion: Body density in professional fashion models is higher, due to taller stature, than in women in general. Moreover, there is an effort on the part of fashion models to lose weight in order to maintain a thin body and a low weight for occupational reasons.

目的:本研究通过皮褶测试,比较了职业时装模特和普通女性的身体特征和身体组成:研究样本包括 90 名活跃在韩国的职业时装模特和 100 名普通女性,所有样本均通过便利抽样法选出。测量按照国际人体测量促进学会制定的标准方法和程序进行。在肱二头肌、肱三头肌、肩胛下和髂上部位测量了身体密度(毫克/毫米)和身体脂肪(%):结果表明,职业时装模特的肱二头肌、肱三头肌、肩胛下和髂上部位明显比一般女性要薄(p 结论:职业时装模特的身体密度比一般女性要高:由于身材高大,职业时装模特的身体密度比一般女性要高。此外,出于职业原因,时装模特会努力减肥,以保持苗条的身材和较低的体重。
{"title":"Comparison of body composition between fashion models and women in general.","authors":"Sunhee Park","doi":"10.20463/jenb.2017.0032","DOIUrl":"10.20463/jenb.2017.0032","url":null,"abstract":"<p><strong>Purpose: </strong>The present study compared the physical characteristics and body composition of professional fashion models and women in general, utilizing the skinfold test.</p><p><strong>Methods: </strong>The research sample consisted of 90 professional fashion models presently active in Korea and 100 females in the general population, all selected through convenience sampling. Measurement was done following standardized methods and procedures set by the International Society for the Advancement of Kinanthropometry. Body density (mg/ mm) and body fat (%) were measured at the biceps, triceps, subscapular, and suprailiac areas.</p><p><strong>Results: </strong>The results showed that the biceps, triceps, subscapular, and suprailiac areas of professional fashion models were significantly thinner than those of women in general (p<.001), and that their waist size was also significantly smaller (p<.001). However, hip circumference showed no significant difference. Body mass index, waist-to-hip ratio, and body fat (%) in professional fashion models were significantly lower than those in women in general (p<.001), while the body density in professional fashion models was significantly greater (p<.001).</p><p><strong>Conclusion: </strong>Body density in professional fashion models is higher, due to taller stature, than in women in general. Moreover, there is an effort on the part of fashion models to lose weight in order to maintain a thin body and a low weight for occupational reasons.</p>","PeriodicalId":15795,"journal":{"name":"Journal of Exercise Nutrition & Biochemistry","volume":"21 4","pages":"22-26"},"PeriodicalIF":0.0,"publicationDate":"2017-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35768533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of acute voluntary loaded wheel running on BDNF expression in the rat hippocampus. 急性负重轮跑对大鼠海马BDNF表达的影响。
Pub Date : 2017-12-31 DOI: 10.20463/jenb.2017.0034
Minchul Lee, Hideaki Soya
[Purpose] Voluntary loaded wheel running involves the use of a load during a voluntary running activity. A muscle-strength or power-type activity performed at a relatively high intensity and a short duration may cause fewer apparent metabolic adaptations but may still elicit muscle fiber hypertrophy. This study aimed to determine the effects of acute voluntary wheel running with an additional load on brain-derived neurotrophic factor (BDNF) expression in the rat hippocampus. [Methods] Ten-week old male Wistar rats were assigned randomly to a (1) sedentary (Control) group; (2) voluntary exercise with no load (No-load) group; or (3) voluntary exercise with an additional load (Load) group for 1-week (acute period). The expression of BDNF genes was quantified by real-time PCR. [Results] The average distance levels were not significantly different in the No-load and Load groups. However, the average work levels significantly increased in the Load group. The relative soleus weights were greater in the No-load group. Furthermore, loaded wheel running up-regulated the BDNF mRNA level compared with that in the Control group. The BDNF mRNA levels showed a positive correlation with workload levels (r=0.75), suggesting that the availability of multiple workload levels contributes to the BDNF-related benefits of loaded wheel running noted in this study. [Conclusion] This novel approach yielded the first set of findings showing that acute voluntary loaded wheel running, which causes muscular adaptation, enhanced BDNF expression, suggesting a possible role of high-intensity short-term exercise in hippocampal BDNF activity.
目的:自愿负重轮跑涉及在自愿跑步活动中使用负重轮跑。在相对高强度和短时间内进行的肌肉力量或能量类型的活动可能导致较少的明显代谢适应,但仍可能引起肌纤维肥大。本研究旨在确定急性自发性轮跑外加负荷对大鼠海马脑源性神经营养因子(BDNF)表达的影响。方法:将10周龄雄性Wistar大鼠随机分为(1)久坐组(对照组);(2)自愿运动与无负荷(no -load)组;(3)自愿运动加负荷组1周(急性期)。实时荧光定量PCR检测BDNF基因表达。结果:空载组和负重组的平均距离水平无显著差异。然而,Load组的平均工作水平显著提高。空载组比目鱼相对重量更大。此外,与对照组相比,负重车轮运行上调了BDNF mRNA水平。BDNF mRNA水平与负荷水平呈正相关(r=0.75),这表明多种负荷水平有助于本研究中发现的负荷轮式跑步与BDNF相关的益处。结论:这种新颖的方法首次发现,急性自愿负重轮跑会导致肌肉适应,从而增强BDNF表达,这表明高强度短期运动可能在海马BDNF活性中发挥作用。
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引用次数: 16
The synergistic effect of protein complex supplementation combined with 12 weeks of resistance training on isokinetic muscular function in untrained young males. 蛋白质复合物补充结合12周阻力训练对未训练的年轻男性等速肌肉功能的协同效应。
Pub Date : 2017-12-31 DOI: 10.20463/jenb.2017.0036
Jiwoong Jang, Hun-Young Park, Choongsung Yoo, Yeram Park, Jisu Kim, Kiwon Lim

Purpose: Resistance exercise training (RET) and an additional intake of dietary protein supplements may improve muscle mass and muscular function, and reduce inflammatory markers. The types, amount, and timing of dietary protein supplements are important for the synergistic effects of resistance training and dietary protein supplements. We hypothesized that a 25.1 g protein complex supplement taken for 12 weeks, immediately before and after resistance exercise, would enhance fat free mass and isokinetic muscular function in young untrained males.

Methods: Eighteen participants were randomly assigned to a placebo (n=8) or protein complex supplement groups (n=10). The RET was a supervised progressive program, 3 times per week for 12-weeks, and was performed progressing 80% of their one repetition maximum (1-RM). Body composition, blood pressure, plasma inflammatory markers, lipid level and isokinetic muscular function were assessed before and after the study period.

Results: There was a significant interaction effect in C-reactive protein (CRP) (p =0.044) among blood vessel inflammatory markers. The protein complex supplement group had shown more effective improvement at 12 weeks intervention compared to the placebo group in isokinetic muscular function. There was a significant interaction effect in peak torque at 60 degrees/sec leg extension (p =0.044), total work at 240 degrees/sec leg extension (p =0.025), and total work at 240 degrees/sec leg flexion (p =0.011).

Conclusion: Protein complex supplementation during RET appears more effective than RET alone in improving isokinetic muscular function for 12 weeks in untrained young men.

目的:抗阻运动训练(RET)和额外摄入膳食蛋白质补充剂可以改善肌肉质量和肌肉功能,并减少炎症标志物。膳食蛋白质补充的类型、数量和时间对抗阻训练和膳食蛋白质补充的协同作用很重要。我们假设,在阻力运动前后连续服用12周的25.1 g蛋白质复合物补充剂,可以提高未受过训练的年轻男性的无脂肪量和等速肌肉功能。方法:18名参与者被随机分配到安慰剂组(n=8)或蛋白质复合物补充剂组(n=10)。RET是一个有监督的渐进式计划,每周3次,持续12周,并进行80%的重复最大值(1-RM)。在研究前后分别评估身体成分、血压、血浆炎症标志物、脂质水平和等速肌肉功能。结果:c反应蛋白(CRP)与血管炎症标志物之间存在显著交互作用(p =0.044)。在12周的干预中,与安慰剂组相比,蛋白质复合物补充剂组在等速肌肉功能方面表现出更有效的改善。在腿伸60度/秒时的峰值扭矩(p =0.044)、腿伸240度/秒时的总功(p =0.025)和腿屈240度/秒时的总功(p =0.011)存在显著的相互作用。结论:在12周未训练的年轻男性中,在RET期间补充蛋白质复合物似乎比单独RET更有效地改善等速肌肉功能。
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引用次数: 2
Effect of treadmill exercise on skeletal muscle autophagy in rats with obesity induced by a high-fat diet. 跑步机运动对高脂饮食诱导肥胖大鼠骨骼肌自噬的影响。
Pub Date : 2017-09-30 DOI: 10.20463/jenb.2017.0013
Do Keun Cho, Dong Hun Choi, Joon Yong Cho

Purpose: This study aimed to investigate the effects of treadmill exercise on body weight, blood biochemistry, and autophagy.

Methods: Triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, insulin, and glucose levels were measured, the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score was calculated, and the soleus muscle was analyzed for autophagy-related factors (Beclin-1, p62, LC3, Lamp-2) in rats with obesity induced by a high-fat diet. Eight-week-old Sprague Dawley rats were fed a high-fat diet for 35 weeks and then subjected to 10 weeks of treadmill exercise. The experimental group was divided into a Normal Diet-Sedentary (ND-SED, n=8) group, an (High-Fat Diet-Sedentary (HF-SED, n=8) group, and an High-Fat Diet + Treadmill Exercise (HF-TE, n=8) group. The intensity of treadmill exercise was set as 8 m/min for 5 min, 11 m/min for 5 min, 15 m/min for 20 min, and 11 m/min for the last 5 minutes. A glucose tolerance test was performed at the 2nd and 8th week of exercise by sampling of tail blood.

Results: With endurance exercise, the HFTE group showed a significant decrease in body weight, with improved blood biochemical indices and HOMA-IR scores, in comparison with the HF-SED group. However, there was no significant difference in Beclin-1, p62, LC3, and Lamp-2 proteins as measured by autophagic flux in the soleus muscle.

Conclusion: Treadmill exercise induced improvements in body weight, body fat, and biochemical indicators of obesity and Type 2 diabetes, but had no effect on autophagy in soleus muscle.

目的:本研究旨在探讨跑步机运动对体重、血液生化和自噬的影响。方法:测定高脂饮食致肥胖大鼠的甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、胰岛素、葡萄糖水平,计算胰岛素抵抗稳态模型评估(HOMA-IR)评分,分析比雷鱼肌自噬相关因子(Beclin-1、p62、LC3、Lamp-2)。8周大的Sprague Dawley大鼠被喂食高脂肪饮食35周,然后进行10周的跑步机运动。实验组分为正常饮食-久坐(ND-SED, n=8)组、高脂肪饮食-久坐(HF-SED, n=8)组和高脂肪饮食+跑步机运动(HF-TE, n=8)组。跑步机运动强度设为8 m/min,第5分钟11 m/min,第20分钟15 m/min,最后5分钟11 m/min。在运动第2周和第8周取尾血进行糖耐量试验。结果:与HF-SED组相比,经过耐力运动后,HFTE组体重明显下降,血液生化指标和HOMA-IR评分均有所改善。然而,比目鱼肌自噬通量测定的Beclin-1、p62、LC3和Lamp-2蛋白无显著差异。结论:跑步机运动对体重、体脂、肥胖和2型糖尿病生化指标均有改善作用,但对比目鱼肌自噬无影响。
{"title":"Effect of treadmill exercise on skeletal muscle autophagy in rats with obesity induced by a high-fat diet.","authors":"Do Keun Cho,&nbsp;Dong Hun Choi,&nbsp;Joon Yong Cho","doi":"10.20463/jenb.2017.0013","DOIUrl":"https://doi.org/10.20463/jenb.2017.0013","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the effects of treadmill exercise on body weight, blood biochemistry, and autophagy.</p><p><strong>Methods: </strong>Triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, insulin, and glucose levels were measured, the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score was calculated, and the soleus muscle was analyzed for autophagy-related factors (Beclin-1, p62, LC3, Lamp-2) in rats with obesity induced by a high-fat diet. Eight-week-old Sprague Dawley rats were fed a high-fat diet for 35 weeks and then subjected to 10 weeks of treadmill exercise. The experimental group was divided into a Normal Diet-Sedentary (ND-SED, n=8) group, an (High-Fat Diet-Sedentary (HF-SED, n=8) group, and an High-Fat Diet + Treadmill Exercise (HF-TE, n=8) group. The intensity of treadmill exercise was set as 8 m/min for 5 min, 11 m/min for 5 min, 15 m/min for 20 min, and 11 m/min for the last 5 minutes. A glucose tolerance test was performed at the 2nd and 8th week of exercise by sampling of tail blood.</p><p><strong>Results: </strong>With endurance exercise, the HFTE group showed a significant decrease in body weight, with improved blood biochemical indices and HOMA-IR scores, in comparison with the HF-SED group. However, there was no significant difference in Beclin-1, p62, LC3, and Lamp-2 proteins as measured by autophagic flux in the soleus muscle.</p><p><strong>Conclusion: </strong>Treadmill exercise induced improvements in body weight, body fat, and biochemical indicators of obesity and Type 2 diabetes, but had no effect on autophagy in soleus muscle.</p>","PeriodicalId":15795,"journal":{"name":"Journal of Exercise Nutrition & Biochemistry","volume":"21 3","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"2017-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.20463/jenb.2017.0013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35455379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
期刊
Journal of Exercise Nutrition & Biochemistry
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