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Trends in Burdens of Disease by Transmission Source (USA, 2005-2020) and Hazard Identification for Foods: Focus on Milkborne Disease. 按传播源划分的疾病负担趋势(美国,2005-2020 年)和食品危害识别:重点关注奶源性疾病。
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-03-28 DOI: 10.1007/s44197-024-00216-6
Michele M Stephenson, Margaret E Coleman, Nicholas A Azzolina

Background: Robust solutions to global, national, and regional burdens of communicable and non-communicable diseases, particularly related to diet, demand interdisciplinary or transdisciplinary collaborations to effectively inform risk analysis and policy decisions.

Objective: U.S. outbreak data for 2005-2020 from all transmission sources were analyzed for trends in the burden of infectious disease and foodborne outbreaks.

Methods: Outbreak data from 58 Microsoft Access® data tables were structured using systematic queries and pivot tables for analysis by transmission source, pathogen, and date. Trends were examined using graphical representations, smoothing splines, Spearman's rho rank correlations, and non-parametric testing for trend. Hazard Identification was conducted based on the number and severity of illnesses.

Results: The evidence does not support increasing trends in the burden of infectious foodborne disease, though strongly increasing trends were observed for other transmission sources. Morbidity and mortality were dominated by person-to-person transmission; foodborne and other transmission sources accounted for small portions of the disease burden. Foods representing the greatest hazards associated with the four major foodborne bacterial diseases were identified. Fatal foodborne disease was dominated by fruits, vegetables, peanut butter, and pasteurized dairy.

Conclusion: The available evidence conflicts with assumptions of zero risk for pasteurized milk and increasing trends in the burden of illness for raw milk. For future evidence-based risk management, transdisciplinary risk analysis methodologies are essential to balance both communicable and non-communicable diseases and both food safety and food security, considering scientific, sustainable, economic, cultural, social, and political factors to support health and wellness for humans and ecosystems.

背景:全球、国家和地区的传染性和非传染性疾病负担,尤其是与饮食有关的疾病负担,需要跨学科或跨学科合作才能有效地为风险分析和政策决策提供信息:对 2005-2020 年美国所有传播源的疫情数据进行分析,以了解传染病和食源性疫情的负担趋势:方法:使用系统查询和数据透视表对 58 个 Microsoft Access® 数据表中的疫情数据进行结构化处理,以便按传播源、病原体和日期进行分析。使用图形表示法、平滑样条、Spearman's rho 等级相关性和非参数趋势测试对趋势进行检验。根据疾病的数量和严重程度进行了危害识别:证据不支持食源性传染病负担呈上升趋势,但观察到其他传染源呈强烈上升趋势。发病率和死亡率以人传人为主;食源性和其他传播源占疾病负担的一小部分。确定了与四种主要食源性细菌疾病相关的危害最大的食物。致命的食源性疾病主要是水果、蔬菜、花生酱和巴氏杀菌乳制品:现有证据与巴氏杀菌奶的零风险假设和生奶的疾病负担增加趋势相冲突。对于未来以证据为基础的风险管理,跨学科风险分析方法对于平衡传染性和非传染性疾病以及食品安全和粮食安全至关重要,同时要考虑科学、可持续、经济、文化、社会和政治因素,以支持人类和生态系统的健康和福祉。
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引用次数: 0
Correction to: Epidemiology of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease in Taiwan. 更正:台湾慢性阻塞性肺病患者骨质疏松症的流行病学。
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 DOI: 10.1007/s44197-024-00248-y
Kuang-Ming Liao, Chuan-Wei Shen, Kai-Lin Chiu, Chun-Hui Lu, Chih-Wun Fang, Chung-Yu Chen
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引用次数: 0
Differences in the Cellular Immune Response during and after Treatment of Sudanese Patients with Post-kala-azar Dermal Leishmaniasis, and Possible Implications for Outcome. 苏丹卡拉-扎尔皮肤利什曼病后遗症患者治疗期间和治疗后细胞免疫反应的差异及其对治疗结果的可能影响。
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-07-15 DOI: 10.1007/s44197-024-00270-0
Ana Torres, Brima Musa Younis, Mohammed Alamin, Samuel Tesema, Lorena Bernardo, Jose Carlos Solana, Javier Moreno, Alaa-Aldeen Mustafa, Fabiana Alves, Ahmed Mudawi Musa, Eugenia Carrillo

Background: The host cellular immune response associated with two treatments for post-kala-azar dermal leishmaniasis (PKDL) - paromomycin plus miltefosine (Arm 1), and liposomal amphotericin B plus miltefosine (Arm 2) - was examined in Sudanese patients before treatment (D0), at the end of treatment (D42), and during the post-treatment period (D180).

Methods: Whole blood samples were stimulated with soluble Leishmania antigen for 24 h (whole blood assay [WBA]) and the concentrations of Th1/Th2/Th17-associated cytokines, IP-10, PDL-1 and granzyme B were determined.

Results: The Arm 1 treatment (98.2% cure rate) induced a Th1/Th2/Th17 response, while the Arm 2 treatment (80% cure rate) induced a Th1/Th2 response. Five Arm 2 patients relapsed and showed lower IFN-γ, TNF and IL-1β concentrations at D0 than non-relapsers in this Arm. In patients with low-IFN-γ-production at D0, Arm 1 treatment led to a better host immune response and clinical outcome than Arm 2 treatment.

Conclusions: A Th1/Th2/Th17 response was associated with a higher cure rate. Patients with low IFN-γ, TNF and IL-1β before treatment are more likely to relapse if they undergo Arm 2-type treatment. Determining IFN-γ, TNF and IL-10 levels prior to treatment could help predict patients at higher risk of relapse/recovery from PKDL.

Trial registration: ClinicalTrials.gov NCT03399955, Registered 17 January 2018, https://clinicaltrials.gov/study/ NCT03399955.

背景:研究了苏丹患者在治疗前(D0)、治疗结束时(D42)和治疗后期间(D180)的两种卡拉-札后皮肤利什曼病(PKDL)治疗方法--副霉素加米特福新(Arm 1)和脂质体两性霉素B加米特福新(Arm 2)--相关的宿主细胞免疫反应:方法:用可溶性利什曼病抗原刺激全血样本 24 小时(全血测定 [WBA]),测定 Th1/Th2/Th17 相关细胞因子、IP-10、PDL-1 和颗粒酶 B 的浓度:结果:Arm 1疗法(治愈率98.2%)诱导了Th1/Th2/Th17反应,而Arm 2疗法(治愈率80%)诱导了Th1/Th2反应。治疗组 2 中有 5 名患者复发,他们在第 0 天时的 IFN-γ、TNF 和 IL-1β 浓度低于未复发者。对于D0时IFN-γ分泌较低的患者,Arm 1治疗的宿主免疫反应和临床结果均优于Arm 2治疗:结论:Th1/Th2/Th17应答与更高的治愈率相关。治疗前IFN-γ、TNF和IL-1β较低的患者如果接受Arm 2治疗,复发的可能性更大。在治疗前测定IFN-γ、TNF和IL-10水平有助于预测PKDL复发/康复风险较高的患者:ClinicalTrials.gov NCT03399955,2018年1月17日注册,https://clinicaltrials.gov/study/ NCT03399955。
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引用次数: 0
Global Research on Pandemics or Epidemics and Mental Health: A Natural Language Processing Study. 关于大流行病或流行病与心理健康的全球研究:自然语言处理研究。
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI: 10.1007/s44197-024-00284-8
Xin Ye, Xinfeng Wang, Hugo Lin

Background: The global research on pandemics or epidemics and mental health has been growing exponentially recently, which cannot be integrated through traditional systematic review. Our study aims to systematically synthesize the evidence using natural language processing (NLP) techniques.

Methods: Multiple databases were searched using titles, abstracts, and keywords. We systematically identified relevant literature published prior to Dec 31, 2023, using NLP techniques such as text classification, topic modelling and geoparsing methods. Relevant articles were categorized by content, date, and geographic location, outputting evidence heat maps, geographical maps, and narrative synthesis of trends in related publications.

Results: Our NLP analysis identified 77,915 studies in the area of pandemics or epidemics and mental health published before Dec 31, 2023. The Covid pandemic was the most common, followed by SARS and HIV/AIDS; Anxiety and stress were the most frequently studied mental health outcomes; Social support and healthcare were the most common way of coping. Geographically, the evidence base was dominated by studies from high-income countries, with scant evidence from low-income counties. Co-occurrence of pandemics or epidemics and fear, depression, stress was common. Anxiety was one of the three most common topics in all continents except North America.

Conclusion: Our findings suggest the importance and feasibility of using NLP to comprehensively map pandemics or epidemics and mental health in the age of big literature. The review identifies clear themes for future clinical and public health research, and is critical for designing evidence-based approaches to reduce the negative mental health impacts of pandemics or epidemics.

背景:近来,全球有关流行病或疫情与心理健康的研究呈指数级增长,传统的系统性综述无法对其进行整合。我们的研究旨在利用自然语言处理(NLP)技术对证据进行系统综合:方法:使用标题、摘要和关键词对多个数据库进行了检索。我们使用文本分类、主题建模和地理解析方法等 NLP 技术系统地识别了 2023 年 12 月 31 日之前发表的相关文献。我们按照内容、日期和地理位置对相关文章进行了分类,输出了证据热图、地理图以及相关出版物趋势的叙述性综述:我们的 NLP 分析确定了在 2023 年 12 月 31 日之前发表的大流行病或流行病与心理健康领域的 77,915 项研究。焦虑和压力是最常见的心理健康结果;社会支持和医疗保健是最常见的应对方式。从地域上看,证据基础主要是来自高收入国家的研究,来自低收入国家的证据很少。大流行病或流行病与恐惧、抑郁和压力同时出现的情况很常见。除北美外,焦虑是各大洲最常见的三个主题之一:我们的研究结果表明,在大文献时代,使用 NLP 全面描绘大流行病或流行病与心理健康的重要性和可行性。该综述为未来的临床和公共卫生研究确定了明确的主题,对于设计循证方法以减少流行病或疫情对心理健康的负面影响至关重要。
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引用次数: 0
Epidemiological Mapping of Cutaneous Leishmaniasis in Saudi Arabia: An Observational Descriptive Study. 沙特阿拉伯皮肤利什曼病流行病学图谱:观察性描述研究。
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-08-26 DOI: 10.1007/s44197-024-00285-7
Basmah Alharbi, Mawahib Ahmed

Cutaneous leishmaniasis (CL) is a parasitic disease that affects individuals worldwide. An epidemiological observational population-cohort study was conducted on the basis of comprehensive research on CL incidence in Saudi and non-Saudi residents. The Ministry of Health recorded the incidence of CL between January 2020 and December 2022. The chi-square test was used to analyze the data and determine CL incidence rates in age-specific incidence rates (ASIRs) and gender between Saudi and non-Saudi residents in Saudi Arabia. The study found that between 2020 and 2022, there were 2280 cases of CL in Saudi Arabia, with 1367 and 913 cases in men and women, respectively. Of Saudi nationals, 64.26% and 12.91% were male and female, respectively. The frequency of CL was higher (87.09%) among non-Saudi residents than among Saudi nationals, with a statistically significant difference (P = 0.001) between the two groups. The ASIRs for CL were higher in patients aged 15-45 years. This study revealed variations in CL incidence rates among the 13 administrative regions; Qassim, followed by Aseer, Ha'il, and Madinah, had higher rates than the other regions. These findings indicate the need for targeted interventions and public health strategies to reduce the burden on CL, particularly among non-Saudi residents.

皮肤利什曼病(CL)是一种影响全球个人的寄生虫病。在对沙特和非沙特居民的皮肤利什曼病发病率进行全面研究的基础上,我们开展了一项流行病学观察性人群队列研究。卫生部记录了 2020 年 1 月至 2022 年 12 月期间的 CL 发病率。研究采用卡方检验法对数据进行分析,确定沙特阿拉伯境内沙特籍和非沙特籍居民的CL发病率在年龄特异性发病率(ASIR)和性别方面的差异。研究发现,2020 年至 2022 年期间,沙特阿拉伯共有 2280 例 CL 病例,其中男性和女性分别为 1367 例和 913 例。在沙特国民中,男性和女性分别占 64.26% 和 12.91%。非沙特居民的 CL 患病率(87.09%)高于沙特国民,两组之间的差异具有统计学意义(P = 0.001)。15-45 岁患者的 CL ASIR 较高。这项研究显示,13 个行政区域的 CL 发病率存在差异;卡西姆(Qassim)、阿赛尔(Aseer)、哈伊勒(Ha'il)和麦地那(Madinah)的发病率高于其他地区。这些研究结果表明,有必要采取有针对性的干预措施和公共卫生策略,以减轻CL的负担,尤其是非沙特居民的CL负担。
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引用次数: 0
Epidemiology of Q Fever in Southeast Europe for a 20-Year Period (2002-2021). 20 年间(2002-2021 年)东南欧 Q 热的流行病学。
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-09-04 DOI: 10.1007/s44197-024-00288-4
Tatjana Pustahija, Snežana Medić, Vladimir Vuković, Zagorka Lozanov-Crvenković, Aleksandra Patić, Mirjana Štrbac, Verica Jovanović, Dragana Dimitrijević, Milunka Milinković, Mirjana Lana Kosanović, Helena C Maltezou, Kassiani Mellou, Sanjin Musa, Marijan Bakić, Sanja Medenica, Nikolina Sokolovska, Nina Vukmir Rodić, Milica Devrnja, Mioljub Ristić, Vladimir Petrović

This study aimed to assess epidemiological trends of Q fever in six countries of Southeast Europe by analysing surveillance data for 2002-2021 period. In this descriptive analysis, we collected and analysed data on confirmed human Q fever cases, obtained from the national Public Health Institutes of Bosnia and Herzegovina, Croatia, Greece, Montenegro, North Macedonia and Serbia. Overall, 2714 Q fever cases were registered during the 20-year period. The crude average annual notification rate was 0.82 (± 2.06) (95% CI: 0.47-1.16) per 100,000 inhabitants, ranged from 0.06 (± 0.04) (95% CI: 0.04-0.08) /100,000 in Greece to 2.78 (± 4.80) (95% CI: 0.53-5.02) /100,000 in the Republic of Srpska (entity of Bosnia and Herzegovina). Significant declining trends of Q fever age standardized rates were registered in Croatia, the Federation of Bosnia and Herzegovina, North Macedonia and Serbia, with an average annual change of -30.15%; -17.13%; -28.33% and - 24.77%, respectively. An unequal spatial distribution was observed. The highest average age-specific notification rate was reported in the 20-59 age group (0.84 (± 0.40) (95% CI: 0.65-1.02) /100,000). Most cases (53.69%) were reported during the spring. Q fever remains a significant public health threat in this part of Europe. The findings of this study revealed the endemic maintenance of this disease in the including countries, with large regional and subnational disparities in notification rates. A downward trend was found in Q fever notification rates across the study countries with the average notification rate higher than in the EU/EEA, during the same period.

本研究旨在通过分析 2002-2021 年期间的监测数据,评估 Q 热在东南欧六国的流行趋势。在这项描述性分析中,我们收集并分析了波斯尼亚和黑塞哥维那、克罗地亚、希腊、黑山、北马其顿和塞尔维亚国家公共卫生研究所提供的人类 Q 热确诊病例数据。20 年间共登记了 2714 例 Q 热病例。粗平均年通报率为每 10 万居民 0.82 (± 2.06) (95% CI: 0.47-1.16),从希腊的 0.06 (± 0.04) (95% CI: 0.04-0.08) /100,000 到塞族共和国(波斯尼亚和黑塞哥维那实体)的 2.78 (± 4.80) (95% CI: 0.53-5.02) /100,000 不等。克罗地亚、波斯尼亚和黑塞哥维那联邦、北马其顿和塞尔维亚的 Q 热年龄标准化发病率呈显著下降趋势,年均变化率分别为-30.15%、-17.13%、-28.33%和-24.77%。空间分布不均。20-59 岁年龄组的平均通知率最高(0.84 (± 0.40) (95% CI: 0.65-1.02) /100,000)。大多数病例(53.69%)在春季报告。Q 热仍然是欧洲这一地区的一个重大公共卫生威胁。这项研究的结果表明,这种疾病在这些国家仍呈地方性流行,地区和国家以下各级的报告率差异很大。研究国家的 Q 热通报率呈下降趋势,同期平均通报率高于欧盟/欧洲经济区。
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引用次数: 0
A Call for Adopting High-Dose Influenza Vaccines for Adults Aged 65 and Above in Gulf Cooperation Council (GCC) Countries. 呼吁海湾合作委员会 (GCC) 国家为 65 岁及以上的成年人接种大剂量流感疫苗。
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-09-10 DOI: 10.1007/s44197-024-00292-8
Salah T Al Awaidy, Parvaiz A Koul, Faryal Khamis, Fatima Al Slil, Imane Jroundi, Fatima Al Olama, Khalid Hamid Elawad, Musallam Yunus Hassan Abuhasan, Fana Al Oraimi, Mine Durusu Tanriover, Hassan Zaraket

Seasonal influenza poses significant health and economic challenges globally each year, particularly impacting the elderly population (aged ≥ 65 years) with increased rates of hospitalization, and mortality. The population of older adults is steadily increasing in the Gulf Cooperation Council (GCC) countries and is likely to increase even further. In addition, there is a high burden of chronic comorbidities in these countries like diabetes and obesity, which increases the likelihood of severe consequences of influenza infection. The GCC countries also host mass gathering events like Hajj, Umrah pilgrimage, Arba'een (nearby Iraq) pilgrimage, and international sports and business events, which further intensify the risk of outbreaks like influenza. These events facilitate the mixing of visitors from various countries. Thus, influenza activity in this North Hemisphere (NH) geography is usually present even before the availability of NH seasonal influenza vaccine. This is especially problematic for the elderly, whose protection from the previous year's immunization would have waned. Higher dosages of antigens or adjuvants have been used to improve immunogenicity in older people with superior vaccine effectiveness. Therefore, there is a compelling argument in favor of the implementation of high-dose seasonal influenza vaccines in the GCC countries to improve the protection of individuals aged 65 years and older against influenza infection and associated severe complications.

每年的季节性流感都会给全球的健康和经济带来重大挑战,尤其是对老年人口(年龄≥ 65 岁)的影响,住院率和死亡率都会上升。在海湾合作委员会(GCC)国家,老年人口正在稳步增长,并有可能进一步增加。此外,在这些国家,糖尿病和肥胖症等慢性并发症的负担很重,这增加了感染流感造成严重后果的可能性。海湾合作委员会国家还举办朝觐、Umrah 朝圣、Arba'een(伊拉克附近)朝圣以及国际体育和商业活动等大规模集会活动,这进一步加剧了流感等疾病爆发的风险。这些活动为来自不同国家的游客混杂在一起提供了便利。因此,北半球的流感活动通常在北半球季节性流感疫苗上市之前就已出现。这对老年人来说尤其棘手,因为他们上一年接种的疫苗对他们的保护作用已经减弱。曾有人使用较高剂量的抗原或佐剂来提高老年人的免疫原性,并取得了较好的疫苗效果。因此,有充分的理由支持在海湾合作委员会国家接种高剂量季节性流感疫苗,以加强对 65 岁及以上老年人的保护,使其免受流感感染和相关严重并发症的影响。
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引用次数: 0
Correction: Tuberculosis in Ukrainian War Refugees and Migrants in the Czech Republic and Slovakia: A Molecular Epidemiological Study. 更正:捷克共和国和斯洛伐克境内乌克兰战争难民和移民的结核病:分子流行病学研究。
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 DOI: 10.1007/s44197-024-00212-w
Matúš Dohál, Věra Dvořáková, Miluše Šperková, Arash Ghodousi, Maryam Omrani, Igor Porvazník, Erik M Rasmussen, Mária Škereňová, Michaela Krivošová, Olha Konstantynovska, Timothy M Walker, Vladyslav Nikolayevskyy, Daniela M Cirillo, Ivan Solovič, Juraj Mokrý
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引用次数: 0
A Holistic Approach to Cardiometabolic and Infectious Health in the General Population of Reunion Island: The REUNION Study. 留尼汪岛普通人群心脏代谢和感染健康的综合方法:留尼旺研究
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-04-02 DOI: 10.1007/s44197-024-00221-9
Mohammad Ryadh Pokeerbux, Patrick Mavingui, Patrick Gérardin, Nelly Agrinier, Erick Gokalsing, Olivier Meilhac, Maxime Cournot

Introduction: Reunion Island is a French overseas department in the South West Indian Ocean with a unique multi-ethnic population. Cardiovascular diseases are the most common chronic conditions with higher prevalences of hypertension and diabetes compared to mainland France. Moreover, Reunion Island is particularly exposed to vector-borne diseases such as chikungunya and dengue. Our objective is to describe the prevalence of cardiometabolic and infectious diseases in Reunion Island and explore causal mechanisms linking these diseases.

Methods: The REUNION study is an ongoing French prospective study. From January 2022, 2,000 consenting participants (18-68 years old) are being recruited from the general population according to polling lists and random generation of cellphone number. Baseline examination consists of (i) general health examination, assessment of cardiovascular risk factors, markers of subclinical atherosclerosis, bronchial obstruction, neuropathic and autonomic dysfunction, (ii) questionnaires to determine sociodemographic characteristics, diet, exposure to vector-borne diseases, mental health and cognitive functions, social inequalities in health and ethnic origins, (iii) biological sampling for determination of cardiovascular risk factors, seroprevalence of infectious diseases, innovative lipid biomarkers, advanced omics, composition of intestinal, periodontal and skin microbiota, and biobanking.

Conclusions: The REUNION study should provide new insights into the prevalence of cardiometabolic and infectious diseases, as well as their potential associations through the examination of various environmental pathways and a wide range of health aspects.

简介留尼汪岛是西南印度洋上的一个法国海外省,拥有独特的多民族人口。心血管疾病是最常见的慢性疾病,高血压和糖尿病的发病率高于法国本土。此外,留尼汪岛尤其容易受到基孔肯雅病和登革热等病媒传播疾病的影响。我们的目标是描述留尼汪岛心脏代谢疾病和传染病的发病率,并探索这些疾病之间的因果关系:留尼旺研究是法国正在进行的一项前瞻性研究。从2022年1月起,根据投票名单和随机生成的手机号码,从普通人群中招募2000名同意参加的参与者(18-68岁)。基线检查包括:(i) 一般健康检查,评估心血管风险因素、亚临床动脉粥样硬化标志物、支气管阻塞、神经病理性和自主神经功能障碍;(ii) 问卷调查,以确定社会人口特征、饮食、接触病媒传播疾病的情况、(iii) 通过生物采样确定心血管风险因素、传染病血清流行率、创新的脂质生物标记物、先进的全息技术、肠道、牙周和皮肤微生物群的组成以及生物银行。结论:通过对各种环境途径和广泛的健康问题进行研究,REUNION 研究将为了解心血管代谢疾病和传染病的发病率及其潜在关联提供新的视角。
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引用次数: 0
Epidemiological Insights into Autoimmune Bullous Diseases in China: A Comprehensive Analysis. 中国自身免疫性牛皮癣流行病学透视:全面分析。
IF 3.8 4区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2024-09-01 Epub Date: 2024-07-22 DOI: 10.1007/s44197-024-00277-7
Zihua Chen, Lanting Wang, Li Ma, Fanping Yang, Shengan Chen, Jin Yang, Haiqing Gao, Chang Tang, Ying Zhao, Zhen Zhang, Lin Tang, Haiyu Xue, Jian Ying, Yu Xu, Wenhong Zhang, Lingyun Shao, Hanqiu Liu, Xiaoqun Luo

Objective: This study aims to conduct an extensive analysis of autoimmune bullous diseases, particularly pemphigus vulgaris and bullous pemphigoid, in Shanghai, China, from 2016 to 2023. It seeks to understand the demographic profiles, comorbidities, mortality rates, risk factors, and socioeconomic impacts associated with autoimmune bullous disease.

Methods: A cross-sectional study design was employed, enrolling 1,072 patients. Diagnostic measures included clinical manifestations, histopathology, direct immunofluorescence, and serologic tests. The study also involved a detailed socioeconomic analysis and evaluation of occupational risks.

Results: The findings highlight a significant occupational risk in industries requiring enhanced safety measures, with a notable prevalence of autoimmune bullous disease among workers in these sectors. A considerable portion of the patients were from low-income backgrounds with limited literacy, indicating the economic burden of autoimmune bullous disease. A key discovery of the study is the potential pathological link between autoimmune bullous disease and interstitial lung disease.

Conclusion: This research, one of the first comprehensive studies on autoimmune bullous disease in China, underscores the need for targeted healthcare strategies and further investigation into autoimmune bullous disease, particularly its relationship with interstitial lung disease.

研究目的本研究旨在对中国上海从2016年至2023年的自身免疫性大疱性皮肤病,尤其是寻常型丘疹性荨麻疹和大疱性类天疱疮进行广泛分析。研究旨在了解与自身免疫性大疱性皮肤病相关的人口统计学特征、合并症、死亡率、风险因素和社会经济影响:采用横断面研究设计,共纳入 1,072 名患者。诊断措施包括临床表现、组织病理学、直接免疫荧光和血清学检测。研究还涉及详细的社会经济分析和职业风险评估:结果:研究结果表明,在需要加强安全措施的行业中,自身免疫性牛皮癣的职业风险很大,这些行业的工人中自身免疫性牛皮癣的发病率很高。相当一部分患者来自低收入背景,文化水平有限,这表明自身免疫性大疱性红斑狼疮给经济造成了负担。该研究的一个重要发现是自身免疫性大疱性肺病与间质性肺病之间的潜在病理联系:这项研究是中国首次对自身免疫性牛皮癣进行的全面研究之一,它强调了有针对性的医疗保健策略和进一步研究自身免疫性牛皮癣的必要性,尤其是其与间质性肺病的关系。
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引用次数: 0
期刊
Journal of Epidemiology and Global Health
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