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CAPILLARY ELECTROPHORESIS METHOD FOR THE DETERMINATION OF LACTULOSE AND MANNITOL RATIO FOR ESTIMATING INTESTINAL PERMEABILITY 毛细管电泳法测定乳果糖与甘露醇比值估算肠通透性
Pub Date : 2012-01-01 DOI: 10.16883/JFPIU.58224
E. Acar, D. Ö. Ünal, M. Acar, M. Koc
SUMMARY In this study, a simple, rapid and accurate capillary electrophoresis method has been developed for the determination of lactulose and mannitol in urine for estimating the intestinal permeability. The urine samples were prepared to analyze by using solid phase extraction. For analysis a background electrolyte (BGE) consisted of 6 mmol/L sorbic acid, 1.25mmol/L hexadecyltrimethylammoniumbromide (HDTMA), 50 mmol/L LiOH (pH 12.5) was used. Separation was performed at -5 kV over 20 min within the fused capillary column (45 cm, 50 I¼m I.D.) at 20 °C. The method developed was applied a series of urine sample to measure the lactulose/mannitol concentration rate. Key words: Lactulose, Mannitol, Determination, Permeability, Capillary electrophoresis OZET Bu calismada intestinal gecirgenligin incelenmesi amaciyla idrarda laktuloz ve mannitol tayini icin basit, hizli ve dogru bir kapiler elektroforez yontemi gelistirilmistir. Idrar ornekleri kati faz ozutleme yontemi ile analize hazirlanmistir. Analizler icin 6 mmol/L sorbik asit, 1.25 mmol/L hekzadesil trimetil amonyum bromur (HDTMA), 50 mmol/ L LiOH iceren pH si 12.5 e karsilik gelen destek elektrolit kullanilmistir. Ayrim 45 cm 50 I¼m ic capli fused silika kolonda 20 °C sicaklikta -5 kV ayirma potansiyeli kullanilarak 20 dk icerisinde gerceklestirilmistir. Gelistirilen yontem laktuloz / mannitol derisim oranlarini olcmek icin bir seri idrar numunesine uygulanmistir. Anahtar Kelimeler: Laktuloz, Mannitol, Tayin, Gecirgenlik, Kapiler elektroforez
本研究建立了一种简便、快速、准确的毛细管电泳测定尿中乳果糖和甘露醇的方法,用于估计肠道通透性。制备尿样,采用固相萃取法进行分析。背景电解液(BGE)为6 mmol/L山梨酸、1.25mmol/L十六烷基三甲基溴化铵(HDTMA)、50 mmol/L LiOH (pH 12.5)。在熔融毛细管柱(45 cm, 50 μ m id)中,在-5 kV, 20分钟内,在20°C下进行分离。将该方法应用于一系列尿样中乳果糖/甘露醇浓度率的测定。【关键词】乳果糖,甘露醇,测定,渗透性,毛细管电泳OZET;甘露醇,甘露醇;甘露醇;Idrar或nekleri kati faz ozutleme将分析hazirlanmiir。分析剂为6 mmol/L山梨酸,1.25 mmol/L三甲基溴铵(HDTMA), 50 mmol/L LiOH, pH值为12.5 mmol/L karsilik gelen destek eletrolit kullanilmisir。直径45厘米,直径50厘米,直径1 / 4厘米,直径20°C,直径5千伏,直径5千伏,直径5千伏,直径20千伏,直径5千伏。Gelistirilen system - laktuloz / mannitol - derisim - oranlarini - olmek是一种新型的化学物质。Anahtar Kelimeler: Laktuloz, Mannitol, Tayin, gerecgenlik, Kapiler elektroforez
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引用次数: 0
CYTOTOXIC EFFECTS OF TRIAZOLE FUNGUCIDES 三唑类杀菌剂的细胞毒作用
Pub Date : 2012-01-01 DOI: 10.16883/JFPIU.12230
E. Bülbül, G. Bülbül, G. Özhan
SUMMARY Fungicides are at high risk exposure compounds both pre and post harvest time due to their usage during storage. Fungucides have various benefits on agricultural struggle. Apart from that, studies showed that fungucides also have mutagenic, carcinogenic, chronic toxic effects on nervous system, immune system, hormonal and reproductive system. Triazole group fungicides, prochloraz, tebuconazole, triadimenole and triadimefone, are commonly used in the world. In the study, it is aimed to emphasize about their importance on human and environmental health. And, we evaluated their potential cytotoxic effect on HeLa cells by using MTT and LDH tests. Before the tests application, the parameters like cell counts, incubation times, pesticide concentrations and test circumstances were examined for test optimization. As a result, for MTT cytotoxicity test IC50 values of prochloraz, tebuconazole, triadimefone and triadimenole were recorded in order as 0.4, >1, 0.24 and 0.37 mg/ml. As well for LDH test these values were identified in order as 0.065, 0.985, 0.052 and 0.042 mg/ml. MTT test, used to identify hazards on mitochondrial activity and respiratory chain, showed that cytotoxic effect of prochloraz, triadimefone and triadimenole was dose dependently increased. While tebuconazole showed cytotoxic effect on concentration range studied, it was seen that IC50 values for LDH test which is used to identify membrane damage were lower than IC50 values compared with MTT test. The obtained results would draw attention to expand researches on toxic effects of triazole fungicides which are identified as cytotoxic for human and environment health. Also, it is believed to take necessary precautions for usage of these compounds. Key words: Triazole fungicides, MTT test, LDH test, Cytotoxicity
杀菌剂在收获前和收获后都是高风险暴露化合物,因为它们在储存期间使用。杀菌剂在农业生产中有多种效益。除此之外,研究表明杀菌剂还对神经系统、免疫系统、激素和生殖系统具有诱变、致癌、慢性毒性作用。国际上常用的三唑类杀菌剂有:丙氯嗪、戊康唑、三唑咪唑和三唑美酮。在这项研究中,它旨在强调它们对人类和环境健康的重要性。并通过MTT和LDH试验评估其对HeLa细胞的潜在细胞毒作用。在进行试验前,考察了细胞计数、孵育时间、农药浓度和试验环境等参数,以优化试验。因此,在MTT细胞毒性试验中,prochloraz、tebuconazole、triadimefone、triadadole的IC50值依次为0.4、>1、0.24、0.37 mg/ml。LDH检测结果依次为0.065、0.985、0.052和0.042 mg/ml。MTT试验鉴定对线粒体活性和呼吸链的危害,结果显示丙氯嗪、三二美酮和三三美哚的细胞毒作用呈剂量依赖性增强。在研究浓度范围内,戊康唑表现出细胞毒作用,但用于鉴定膜损伤的LDH试验的IC50值低于MTT试验的IC50值。本研究结果将引起人们对三唑类杀菌剂毒性作用研究的重视,这些杀菌剂对人体和环境健康具有细胞毒性。此外,人们认为在使用这些化合物时应采取必要的预防措施。关键词:三唑类杀菌剂,MTT试验,LDH试验,细胞毒性
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引用次数: 3
THE WILD EDIBLE PLANTS OF WESTERN NIGDE ALADAGLAR MOUNTAINS (CENTRAL TURKEY) 阿拉达格勒山脉西部的野生可食植物(土耳其中部)
Pub Date : 2011-01-01 DOI: 10.16883/JFPIU.16673
E. Ozdemir, .. K.Alpinar
Bu calismada Nigde-Aladaglarin Batisinda yenebilen yabani turlerden 13 familyaya ait 3 3 bitki turu belgelenmistir. Turler en cok taze olarak yen­mektedir. Gida olarak kullanilan bitkilerin en cok kullanilan kismi toprak ustu kisimlaridn. Bitkiler dogal yetisme ortamlarindan, bilgi alinan kisiler ile birlikte toplanmistir. Yapilan arazi calismalari sirasinda Bati Aladaglar bolgesinde bulunan tum yerlesim yerleri (5 ilce ve 10 koy) Nisan 2004 -Ekim 2004 tarihleri arasinda ziyaret edilmistir.
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引用次数: 6
PLANTS USED FOR MEDICINAL PURPOSES IN KARAMAN PROVINCE (SOUTHERN TURKEY) 卡拉曼省药用植物(土耳其南部)
Pub Date : 2011-01-01 DOI: 10.16883/JFPIU.00477
N. Özhatay, .. S.Koçak
Cok eski yerlesim alani olan Karaman ili ettiobotanik acidan arastirilmistir. Yorede yapilan arazi calismalarinda 108 yerlesim alani ziyaret edilmis ve 518 bitki ornegi toplanmistir. Toplanan bitkilerin degerlendirilmesi sonucunda 38 familyaya ait 78 bitki taksonunun tibbi kullanimlarinin oldugu belirlenmistir. Tibbi amacla kullanilan bitkilerin bilimsel adlari ve kullanilislari ile ilgili bilgiler (bitkilerin yoresel adlan, kullanilan kisimlari, hazirlama yontemleri ve kullanilislari) tablo halinde verilmistir.
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引用次数: 10
DETERMINATION OF BORONS IN 18 BOTTLED MINERAL WATERS IN TURKEY 土耳其18种瓶装矿泉水中硼的测定
Pub Date : 2011-01-01 DOI: 10.16883/JFPIU.90732
P. Köseoğlu, .. U.Kolak
Bu calismanin amaci Turkiye'nin cesitli bolgelerinden satin alinmis 18 maden suyu numunesinin bor iceriginin belirlenmesidir. Spektrofotometrik bor tayininde organik reaktif olarak azometin-H kullanilmistir. Mineral sulari icin bor limiti 2.4 mg/L'dir. Bu calismada orneklerdeki bor konsantrasyonlari 0.23 - 10.53 mg/L arasinda degismektedir. Keywords: Boron; Mineral waters; Spectrophotometrically determination; Azomethine-H.
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引用次数: 0
IN VITRO ANTIMICROBIAL ACTIVITIES OF WIDELY USED CHEMICAL DISINFECTANTS AGAINST VARIOUS MICROORGANISMS 常用化学消毒剂对多种微生物的体外抑菌活性研究
Pub Date : 2011-01-01 DOI: 10.16883/JFPIU.15273
S. Döşler, A. Güzel, B. Çelik
Activities of seven different disinfectants that are used commonly against bacteria, fungi and spores have been assessed by using the European Standard EN 1276, EN 1650 and EN 13704 methods, respectively. Disinfectants that contain sodium hypochloride, cationic surfactants and their combinations were found to be effective in five minutes against Escherichia coli ATCC 10799, Staphylococcus aureus ATCC 6538, Enterococcus faecalis ATCC 29212 and Candida albicans ATCC 10231 strains. Disinfectants that contain anionic and non-ionic surfactants and organic chloride compounds were found to be effective in 15 minutes against E. coli ATCC 10799 and S. aureus ATCC 6538, and in 30 minutes against E.faecalis ATCC 29212 and C.albicans ATCC 10231. Organic chloride compound and cationic surfactant - alcohol ethoxylate combination showed sporicidal activity against Bacillus subtilis ATCC 6633 spores in 15 minutes. We found the producer's recommended concentrations were sufficient to achieve an effective disinfection against vegetative bacteria and yeast, but not to bacterial spores.
采用欧洲标准EN 1276、EN 1650和EN 13704的方法分别对常用的七种不同消毒剂的活性进行了评估,这些消毒剂通常用于细菌、真菌和孢子。含有次氯酸钠、阳离子表面活性剂及其组合的消毒剂在5分钟内对大肠杆菌ATCC 10799、金黄色葡萄球菌ATCC 6538、粪肠球菌ATCC 29212和白色念珠菌ATCC 10231菌株有效。含有阴离子和非离子表面活性剂以及有机氯化合物的消毒剂在15分钟内对大肠杆菌ATCC 10799和金黄色葡萄球菌ATCC 6538有效,在30分钟内对粪肠杆菌ATCC 29212和白色念珠菌ATCC 10231有效。有机氯化物与阳离子表面活性剂乙醇-乙氧基酸酯组合在15分钟内对枯草芽孢杆菌ATCC 6633孢子有明显的杀孢活性。我们发现生产商推荐的浓度足以实现对植物性细菌和酵母的有效消毒,但不能对细菌孢子。
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引用次数: 0
HPLC-UV METHOD TRANSFER FOR UPLC IN BIO ANALYTICAL ANALYSIS: DETERMINATION OF TERBINAFINE FROM HUMAN PLASMA 高效液相色谱-紫外转移法用于生物分析分析:人血浆中特比萘芬的测定
Pub Date : 2011-01-01 DOI: 10.16883/JFPIU.33235
.. D.Ozerunal
Analiz laboratuarlari yuksek miktardaki ornekleri en kisa zamanda analiz etmek zorundadir. Bu problemi cozmek icin hizli ve etkin yeni kalitatif ve kantitatif analiz yontemleri gelistirilmelidir. Ilac ve ilgili bilesikler icin sivi kromatografisi yontemi uygundur. Ancak, Yuksek Basincli Sivi Kromatografisi (YBSK) ile analiz sureleri 10-45 dakika arasindadir. Ultra Performans Sivi Kromatografisi (UPSK) kullanimi hizi ve hassasiyeti yuzunden yenilikci bir yaklasim olabilir. Farmasotik ve biomedikal analizlerde bu teknik son yillarda oldukca genis kullanim alam bulmustur. YBSK yontemlerinin UPSK sistemlerine aktarimi ilac endustrisinde ilac gelistirme ve kalite kontrol prosesinde zamani kisaltmak amaciyla sikca kullanilmaktadn. Terbmafniin insan plasmasindan analizi model olarak alinarak, gelistirilen hizli ve guvenilir YBSK yontemi UPSK'ne metod transferi yapilmistir. Ilk analiz yonteminde Tebinafinin plasmadan analizi HPLC sisteminde Zorbax SB-Aq C18 kolon kullanilmistir. Mobil faz, 50 % H 3 P0 4 cozeltisi/ Asetonitril (40/60) v/v), 0.8 ml/dak akis hizmda calisilmista. Terbinafin ve propil parabenin alikonma zamanlari sirasiyla, 17.43 ve 7.27 dakika bulunmustur. Gelistirilen bu metod benzer kolon dolgu materyali kullanilarak UPSK sistemine transfer edilmistir. Waters Acquity BEH C18 1.7 fim 2.1 x 50 mm kolon 50 % H 3 P0 4 cozeltisi/ACN (50/50, v/v) mobil faz olarak 0.3 ml/dakika akis hizinda kullanilmistir. Terbinafin ve propil parabenin alikonma zamanlan sirasiyla, 2.98 ve 0.92 dakika elde edilmistir. Terbinafinin UBSK ile analiz zamani UBSK ne oranla 6 kat daha azdir ve benzer pik ozelliklerinde, 2.98 dakika da elue edilmistir.
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引用次数: 2
THE USE OF WILD EDIBLE PLANTS IN KURECIK (AKCADAG/MALATYA) 库列克(akcadag / malatya)野生食用植物的利用
Pub Date : 2011-01-01 DOI: 10.16883/JFPIU.30064
Y. Yeşil, E. Akalın
Bu calismada Kurecik (Akcadag/Malatya) Bucagi'nda gida, baharat ve cay olarak kullanilan 75 dogal tur tespit edilmistir. Bunlarin arasindan 20 tur ayni zamada tedavi amaciyla kullanilmaktadir. En cok kullanilan bitkilerin bulundugu familyalar; Labiatae (14 tur), Rosaceae (10 tur), Compositae (10 tur) ve Polygonaceae (6 tur)'dir. Bazi endemik turler de (10 tur) bolgede yasayanlar tarafindan kullanilmaktadir.
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引用次数: 13
TAXONOMICAL ANATOMICAL AND KARYOLOGICAL REMARKS ON TWO ENDEMIC CENTAUREA L. SPECIES IN TURKEY: C. kilaea Boiss. & C. hermannii F. Hermann 土耳其特有的两种半马属植物的分类、解剖和核学研究。赫尔曼
Pub Date : 2011-01-01 DOI: 10.16883/JFPIU.45236
B. Gürdal, .. N.Özhatay
Centaurea kilaea, Turkiye'nin kuzeybati kiyisi boyunca oldukca yaygin bir yayilisi bulunan endemik bir turdur. Centaurea hermannii de yakin bir turu olmayan, Turkiye'nin kuzey batisinda yayilis yapan oksin endemik bir turdur. Bu calismada C kilaea ve C hermannii 'nin kromozom sayilari ile yayilislari incelenerek, tehdit ve korunma degerleriyle ilgili yaklasimlar ortaya konulmustur. Calismada ayrica bu turlerin anatomik ozellikleri belirlenmistir.
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引用次数: 2
MORPHOLOGICAL AND ANATOMICAL CHARACTERISTICS OF Veronica turrilliana Stoj.& Stef. (Scrophulariaceae): THE RARE AND THREATENED SPECIES OF TURKEY 牛头草的形态解剖特征。&孙燕姿。(玄参科):土耳其的珍稀濒危物种
Pub Date : 2011-01-01 DOI: 10.16883/JFPIU.04436
S. Demirci, N. Özhatay, E. Akalın
Balkan endemigi olan Veronica turrilliana Stoj. & Stef. Trakya'nin kuzeyinde oldukca genis bir yayilisa sahip olan ve Bern Sozlesmesi Ek Liste I'de yer alan nadir bir turdur. Ille kez 1923 yilinda N. Stojanov ve B. Stefanov tarafindan Bulgaristan'in guneydogusunda, Istranca daglarindan toplanan orneklerle bilim dunyasina tanitilmistir. Bu calismada V. turrilliana turunun morfolojik ve tanitici ozellikleri, yayilisi, tehdit ve korunmasi ile ilgili gorusler verilmistir. Ayrica toprak ustu kisminin anatomik ozellikleri belirtilmistir. Key words: Veronica turrilliana, European Turkey, Morphology, Anat­omy, Description, Threats, Conservation
{"title":"MORPHOLOGICAL AND ANATOMICAL CHARACTERISTICS OF Veronica turrilliana Stoj.& Stef. (Scrophulariaceae): THE RARE AND THREATENED SPECIES OF TURKEY","authors":"S. Demirci, N. Özhatay, E. Akalın","doi":"10.16883/JFPIU.04436","DOIUrl":"https://doi.org/10.16883/JFPIU.04436","url":null,"abstract":"Balkan endemigi olan Veronica turrilliana Stoj. & Stef. Trakya'nin kuzeyinde oldukca genis bir yayilisa sahip olan ve Bern Sozlesmesi Ek Liste I'de yer alan nadir bir turdur. Ille kez 1923 yilinda N. Stojanov ve B. Stefanov tarafindan Bulgaristan'in guneydogusunda, Istranca daglarindan toplanan orneklerle bilim dunyasina tanitilmistir. Bu calismada V. turrilliana turunun morfolojik ve tanitici ozellikleri, yayilisi, tehdit ve korunmasi ile ilgili gorusler verilmistir. Ayrica toprak ustu kisminin anatomik ozellikleri belirtilmistir. Key words: Veronica turrilliana, European Turkey, Morphology, Anat­omy, Description, Threats, Conservation","PeriodicalId":15850,"journal":{"name":"Journal of Faculty Pharmacy of Istanbul University","volume":"1 1","pages":"17-27"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89919712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Faculty Pharmacy of Istanbul University
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