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EXPRESS: The Hitchhiker's Guide to Feline Xanthinuria. 《猫黄尿症漫游指南》。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-02-05 DOI: 10.1177/1098612X261424299
Michelle Misong Kim, Brandon Velie, Paul Sheehy, Natalie Courtman, Emily Pritchard, Bianca Haase

Feline xanthinuria is a rare autosomal recessive disorder of purine metabolism, due to genetic mutations in the xanthine dehydrogenase (XDH) gene. It is characterised by excessive excretion and accumulation of xanthine in the urine, which can lead to the formation of xanthine uroliths. Xanthine uroliths may be present in both upper and lower urinary tract, causing clinical signs associated with renal disease and feline lower urinary tract disorders (FLUTD). Hallmark diagnostic findings of xanthinuria are elevated xanthine and hypoxanthine, and reduced uric acid concentrations in serum and urine. Uroliths can be submitted for compositional analysis to confirm the presence of xanthine and definitive diagnosis for xanthinuria. Management involves dietary modification to purine restricted diets, and increased fluid intake. Commercially available renal diets are preferred over urinary diets due to their lower protein composition, and consulting veterinary nutritionists is strongly recommended. Urinary alkalisation is not considered effective method for the dissolution of xanthine uroliths due to their poor solubility. Despite these interventions, recurrence of xanthine urolithiasis can occur. Given the limited treatment options and risk of recurrence, feline xanthinuria is a life-long condition which requires ongoing management and monitoring to mitigate complications. This review will provide an overview of the current understanding of the pathophysiological, metabolic and genetic aspects of the disorder and discuss current diagnostic approaches, management strategies and clinical expectations of feline xanthinuria. Findings from this review highlight the need for greater recognition of feline xanthine urolithiasis as a cause of FLUTD, given current gaps in diagnostic methods and treatment options. A deeper understanding of the condition will help veterinarians accurately differentiate it from other causes of FLUTD and support further research aimed at improving detection, prevention, and management of xanthinuria.

猫黄嘌呤尿是一种罕见的嘌呤代谢常染色体隐性遗传病,由黄嘌呤脱氢酶(XDH)基因突变引起。它的特点是过量排泄和黄嘌呤在尿液中的积累,这可能导致黄嘌呤尿石的形成。黄嘌呤尿石可能存在于上尿路和下尿路,引起与肾脏疾病和猫下尿路疾病(FLUTD)相关的临床症状。黄嘌呤和次黄嘌呤升高,血清和尿液中尿酸浓度降低是黄嘌呤尿症的标志性诊断结果。尿石可提交成分分析,以确认黄嘌呤的存在和黄嘌呤尿的明确诊断。治疗包括调整饮食以限制嘌呤的饮食,并增加液体摄入。市售的肾脏饮食比泌尿饮食更受欢迎,因为它们的蛋白质成分较低,强烈建议咨询兽医营养学家。由于黄嘌呤尿石溶解度差,尿碱化不被认为是有效的溶解黄嘌呤尿石的方法。尽管有这些干预措施,黄嘌呤尿石症仍可能复发。鉴于有限的治疗选择和复发风险,猫黄尿症是一种终身疾病,需要持续管理和监测以减轻并发症。本文综述了目前对该疾病的病理生理、代谢和遗传方面的认识,并讨论了目前猫黄尿症的诊断方法、管理策略和临床期望。鉴于目前在诊断方法和治疗选择方面的差距,本综述的研究结果强调需要更多地认识到猫黄嘌呤尿石症是flud的一个原因。更深入地了解这种情况将有助于兽医准确地将其与其他原因的flud区分开来,并支持旨在改进黄嘌呤尿的检测、预防和管理的进一步研究。
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引用次数: 0
EXPRESS: Ocular findings in cats with feline infectious peritonitis treated with GS-441524: A preliminary prospective study of 118 cases. EXPRESS:用GS-441524治疗猫传染性腹膜炎的眼部发现:118例初步前瞻性研究。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-02-05 DOI: 10.1177/1098612X261424314
Magnolia Bell, Simon Pot, Solène M Meunier, Andrea Spiri, Sandra Felten, Regina Hofmann-Lehmann, Antonella Rampazzo, Anja Suter

This content has been temporarily removed for correction.

目的本研究旨在描述诊断为猫传染性腹膜炎(FIP)的猫的眼部特征和性质,并评估GS-441524抗病毒治疗对眼部表现的影响。方法研究参与者由xxx兽医医院的FIP研究小组前瞻性招募,为期一年。共有118只被诊断为FIP的猫接受了全面的标准化半定量眼科检查。基线检查中出现眼部异常的猫在开始口服抗病毒治疗GS-441524后的第7天和第42天接受随访检查。记录和回顾整个治疗期间的变化。结果基线检查中,40.1%(48/118)的猫有眼部异常,最常见的相关表现为前葡萄膜炎、角沉淀和绒毛膜视网膜炎。在GS-441524的整个治疗过程中,所有眼节均观察到显著改善,大多数病例在治疗的前7天内迅速改善。少数病例仍有残留的绒毛膜视网膜病变和玻璃体细胞。本研究表明FIP猫的眼部异常比之前报道的更为常见。潜在威胁视力的后段改变经常发生,口服GS-441524治疗导致大多数眼部病变,特别是葡萄膜炎和脉络膜视网膜炎的快速改善。这些发现支持将眼科检查作为疑似或确诊FIP猫的临床评估的一部分。
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引用次数: 0
EXPRESS: A Krackow-based Suture Technique as a Novel Alternative for Feline Patellar Fracture Repair: A Biomechanical Comparison. 基于krackow的缝合技术作为猫髌骨骨折修复的新选择:生物力学比较。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-02-05 DOI: 10.1177/1098612X261424298
Min-Young Kim, Eun-Seok Jeong, Sangyul Lee, Hwi-Yool Kim

Objectives: To evaluate the biomechanical properties of the combination of circumferential and Krackow sutures using FiberWire, compared to the conventional methods in feline transverse patellar fractures.

Methods: Twenty-four feline cadaveric pelvic limbs (mean weight 3.74 kg) were harvested, and the patella of each limb was osteotomized transversely to simulate a fracture. The limbs were then randomly assigned to one of three stabilization methods (n=8 per group). Group 1 (PFW) was stabilized with a modified tension band wire with a 0.9 mm Kirschner wire and No. 2 FiberWire. Group 2 (CFS) was stabilized with a circumferential and figure-of-eight suture with No. 2 FiberWire. Group 3 (CKS) was stabilized with a circumferential and Krackow suture with No. 2 FiberWire. All knee joints were fixed at a 135° neutral standing angle and tested by applying tensile force. Loads at 1, 2, and 3 mm gap formation, the maximum failure load and failure modes were recorded.

Results: At 1 mm displacement, Group 3 (96.1±18.6 N) was significantly stronger than Group 1 (p < 0.017). At 2 mm and 3 mm displacements, Group 3 (162.4±12.2 N and 238.6±25.4 N) was significantly stronger than both Group 1 and 2 (p < 0.017). The maximum failure load of Group 3 (352.3±31.0 N) was significantly higher than Group 1 and 2 (p < 0.017). The primary failure mode was pin pull-out (Group 1), suture pull-out (Group 2), and tendon rupture (Group 3).

Conclusions and relevance: The combination of circumferential and Krackow suture technique provides greater resistance to fragment displacement and construct failure than conventional methods in this ex vivo feline patella fracture model.

目的:对比传统方法治疗猫髌骨横向骨折的生物力学性能,评价FiberWire环形和Krackow联合缝合的生物力学性能。方法:取24只平均体重3.74 kg的猫尸体骨盆肢,横截髌骨模拟骨折。然后将四肢随机分配到三种稳定方法中的一种(每组n=8)。第一组(PFW)采用改良张力带钢丝与0.9 mm克氏针和No. 2 FiberWire进行稳定。2组(CFS)采用2号FiberWire环形和8字形缝合进行稳定。第3组(CKS)采用2号FiberWire环形和Krackow缝合进行稳定。所有膝关节固定在135°中立站立角度,并施加拉力进行测试。记录了1、2和3mm间隙形成时的载荷、最大失效载荷和失效模式。结果:1 mm位移时,3组(96.1±18.6 N)显著强于1组(p < 0.017)。在2 mm和3 mm位移时,组3(162.4±12.2 N和238.6±25.4 N)显著强于组1和组2 (p < 0.017)。组3的最大失效负荷(352.3±31.0 N)显著高于组1和组2 (p < 0.017)。主要失效模式为针拔出(组1)、缝线拔出(组2)、肌腱断裂(组3)。结论及意义:在离体猫髌骨骨折模型中,与传统缝合方法相比,环向和Krackow缝合技术的结合可提供更大的抗碎片移位和构建失败的能力。
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引用次数: 0
EXPRESS: Comparison of Thames Medical CAT+ Doppler and AutoCAT+ Automatic Blood Pressure Monitor devices for non-invasive blood pressure measurement in cats. EXPRESS:泰晤士医学CAT+多普勒和AutoCAT+自动血压监测仪在猫无创血压测量中的比较。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-02-05 DOI: 10.1177/1098612X261424313
Eleanor Marriott

ObjectivesA comparative assessment of systolic blood pressure (SBP) measurement was carried out for anaesthetised and conscious cats by using two non-invasive approaches based on the Doppler method and a newly developed oscillometric instrument.MethodsSystemic blood pressure (SBP) was recorded on 131 occasions in 26 cats entering a shelter environment. Six of these cats were monitored while under a general anaesthetic for elective procedures and the rest were conscious during routine health assessment. A paired approach was followed using the Doppler method followed immediately by the oscillometric approach. Mean values and coefficient of variations were calculated. A normal distribution was confirmed before a standard Bland-Altman analysis was completed.ResultsThe mean SBP ± standard deviation for the 131 paired readings was 113.3 ± 23.9 mmHg and 116 ± 26.7 mmHg for the Doppler and oscillometric methods respectively. The small difference in means was not significant. Anaesthetised cats had significantly lower SBP values than those that were conscious. The data set for 16 cats with three replicated paired measurements and a subset of 12 with five such replicated measurements also provided similar normally distributed mean values and a high correlation coefficient. The Bland-Altman plot suggested a positive bias of the oscillometric approach of + 3.07 ± 12.3 mmHg (limits of agreement of -21.0 to 27.1 mmHg) and + 4.93 ± 9.38 mmHg (limits of agreement of -13.5 to 23.3 mmHg) for the 16 and 12 cat subgroups respectively. There was 100% agreement between the two methods in allocation to a hypertension class.Conclusions and relevanceThe results establish that the new AutoCAT+ instrument met some of the guidelines for assessing such instruments for veterinary use with cats with a normal range of blood pressure. Further work is needed with a larger data set spanning hypotension to hypertension for complete validation.

目的对麻醉猫和清醒猫采用多普勒法和一种新发明的示波仪两种无创方法测量收缩压进行比较。方法对26只猫进行131次体血压测定。其中6只猫在接受选择性手术的全身麻醉时被监测,其余的猫在常规健康评估时是有意识的。采用多普勒法进行配对,随后立即采用振荡法。计算平均值和变异系数。在完成标准Bland-Altman分析之前,证实了正态分布。结果多普勒法和示波法131对读数的平均收缩压±标准差分别为113.3±23.9 mmHg和116±26.7 mmHg。平均值的微小差异不显著。麻醉猫的收缩压值明显低于清醒猫。16只猫的数据集有3次重复成对测量,12只猫的数据集有5次重复测量,也提供了相似的正态分布平均值和高相关系数。Bland-Altman图显示,16和12个cat亚组的振荡测量方法分别为+ 3.07±12.3 mmHg(-21.0至27.1 mmHg的一致性界限)和+ 4.93±9.38 mmHg(-13.5至23.3 mmHg的一致性界限)的正偏倚。两种方法在高血压分类上的一致性为100%。结论和相关性结果表明,新的AutoCAT+仪器符合评估此类仪器在正常血压范围内的猫的兽医使用的一些指南。进一步的工作需要更大的数据集,跨越低血压到高血压,以完成验证。
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引用次数: 0
EXPRESS: A psyllium-supplemented gastrointestinal diet is effective for the management of chronic constipation in cats: a 6-month controlled clinical trial. EXPRESS:一项为期6个月的对照临床试验:一种添加车前草的胃肠道饮食对猫的慢性便秘有效。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-02-03 DOI: 10.1177/1098612X261420519
Julie Rochon, Hélène Charles, Vincent Biourge, Jeremy Laxalde, Mikel Goñi García-Falces, Danielle Dito

Recurrent constipation is common in cats. Long-term management should include dietary modifications.ObjectiveThis study evaluated the efficacy of a psyllium-enriched diet for the management of chronic constipation in cats.MethodsA multi-centre, controlled, blinded, 6-month trial, randomly assigned client-owned cats to a gastrointestinal test diet containing 6% psyllium or similar control diet containing 0.5% psyllium (as-fed values). Inclusion criteria included ≥2 constipation episodes in the previous 6 months and ≥2 constipation signs for ≥14 days. Constipation severity (stool consistency and frequency, and defecation pain/difficulty) was scored on Days 7, 30, 60, 90 and 180. Cats could switch diets if constipation signs did not improve, or the diet was not tolerated. Diet failure was defined as study withdrawal due to lack of improvement in constipation, new gastrointestinal signs, or diet switch. Cats switching diets were new cases in the group into which they moved, and statistical analyses (linear and linear mixed models) included them in both diet groups.ResultsOf 49 cats enrolled, 2 were removed for non-compliance, leaving 26 in the test group (18 assigned, 8 switched from control), and 30 in the control group (29 assigned, 1 switched from test). 19/26 and 11/30 cats completed 6 months of the test and control diet, respectively. The rate of diet failure for gastrointestinal reasons was significantly higher in the control (22/30 [73.3%]) versus test group (7/26 [26.9%]; P = 0.0005). Constipation signs improved significantly from baseline in both groups at each visit after Day 7. For stool consistency, improvement was significantly greater in the test versus control group except at Day 30.Conclusions and relevanceIn cats with chronic constipation, a 6% psyllium-supplemented gastrointestinal diet resulted in sustained improvement of clinical signs, a significantly lower probability of diet failure and greater improvements in stool consistency than a control gastrointestinal diet.

复发性便秘在猫身上很常见。长期管理应包括饮食调整。目的本研究评估了车前草营养饮食对猫慢性便秘的治疗效果。方法采用多中心、对照、盲法、为期6个月的试验,将客户饲养的猫随机分配到含有6%车前草的胃肠道试验饲粮或含有0.5%车前草的类似对照饲粮(按饲粮值计算)。纳入标准为:前6个月便秘≥2次,便秘症状≥2次,持续≥14天。便秘严重程度(大便一致性和频率,以及排便疼痛/困难)在第7、30、60、90和180天进行评分。如果便秘症状没有改善,或者猫不能忍受这种饮食,猫可以改变饮食。饮食失败被定义为由于便秘没有改善、新的胃肠道症状或饮食改变而退出研究。猫改变饮食习惯在它们进入的组中是新病例,统计分析(线性和线性混合模型)将它们纳入两个饮食组。结果在入组的49只猫中,有2只因不依从性被剔除,剩下26只在试验组(18只被分配,8只从对照组转来),30只在对照组(29只被分配,1只从测试转来)。分别有19/26和11/30只猫完成了6个月的试验和对照饮食。对照组因胃肠道原因导致的饮食失败率(22/30[73.3%])显著高于试验组(7/26 [26.9%];P = 0.0005)。在第7天之后的每次访问中,两组的便秘症状均较基线显著改善。在粪便一致性方面,除了第30天,试验组与对照组相比改善明显更大。在患有慢性便秘的猫中,与对照组胃肠道饮食相比,添加6%车前草的胃肠道饮食可持续改善临床症状,显著降低饮食失败的可能性,并显著改善粪便一致性。
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引用次数: 0
EXPRESS: Enhanced environmental acclimation of cats using an innovative passive diffuser of the Facial-Marking Pheromone (F3). EXPRESS:使用一种创新的面部标记信息素(F3)被动扩散器增强猫的环境适应能力。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-02-01 DOI: 10.1177/1098612X261422953
Alessandro Cozzi, Miriam Marcet Rius, Eva Teruel, Philippe Monneret, Fanny Menuge, Pietro Asproni, Patrick Pageat

ObjectivesThe aim of the study was to evaluate if diffusing the F3 facial-marking pheromone using a novel passive diffusion system can help cats to exhibit behavior suggesting "confidence" in a novel environment.MethodsA crossover trial was performed: cats were placed into two identical, separate experimental rooms for 10 minutes and exposed either to the treatment or to the control solution. Rooms were arranged similar to a normal living space, and the passive diffuser was placed on a shelf. The behaviour of 14 cats was evaluated during the standardised test. Different behavioural parameters were measured via video analysis and submitted to the statistical analysis to evaluate the emotional state of the cats. Data were analysed using general and generalized linear mixed models, as well as a proportion test.ResultsCats did not destroy or play with the diffuser. The statistical analysis showed that the F3-treated cats spent more time in the proximity of the diffuser (p=0.0180). Moreover, F3-treated cats also spent more time laying down (p=0.0191) and playing (p=0.0016) and exhibited more rubbing behaviour (p=0.0102) than controls, while they spent less time sitting (p=0.0180) than controls. Finally, F3-treated cats needed more time to approach the diffuser (p=0.0517). No differences were observed in the other studied behaviours.Conclusions and relevanceThese findings showed for the first time that adapting this novel passive diffusion system to diffuse the F3 pheromone impacts the behaviour of the treated cats, increasing behaviours associated with positive emotions (playing) and acclimation to and suggesting confidence in the environment (rubbing, resting). Moreover, this new system can be adapted for use at home since it is already used there and does not need electricity or heat to function, making it a promising tool to improve the wellbeing of pet cats in different situations.

目的本研究的目的是评估使用一种新的被动扩散系统扩散F3面部标记信息素是否可以帮助猫在新环境中表现出“自信”的行为。方法进行交叉试验:将猫置于两个相同的单独的试验室中10分钟,分别暴露于治疗溶液或对照溶液中。房间的布置类似于正常的生活空间,被动式扩散器被放置在架子上。在标准化测试中,对14只猫的行为进行了评估。通过视频分析测量不同的行为参数,并提交统计分析,以评估猫的情绪状态。数据分析采用一般和广义线性混合模型,以及比例检验。结果猫对扩散器没有破坏和玩耍。统计分析表明,f3治疗的猫在扩散器附近停留的时间更长(p=0.0180)。此外,接受f3治疗的猫也比对照组花更多的时间躺下(p=0.0191)和玩耍(p=0.0016),并表现出更多的摩擦行为(p=0.0102),而他们花更少的时间坐着(p=0.0180)。最后,f3治疗的猫需要更多的时间来接近扩散器(p=0.0517)。在其他被研究的行为中没有观察到差异。这些发现首次表明,适应这种新的被动扩散系统来扩散F3信息素会影响治疗猫的行为,增加与积极情绪(玩耍)相关的行为,以及对环境的适应和暗示信心(摩擦、休息)。此外,这个新系统可以在家里使用,因为它已经在家里使用了,不需要电或热来工作,这使它成为一个有前途的工具,可以在不同的情况下改善宠物猫的健康。
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引用次数: 0
EXPRESS: Efficacy of Mesenchymal Stem Cell Therapy for Treating Deep Corneal Ulcers and Corneal Perforation in Cats: A Retrospective Study. EXPRESS:间充质干细胞治疗猫角膜溃疡和角膜穿孔的疗效:一项回顾性研究。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-02-01 DOI: 10.1177/1098612X261423236
Natthanet Sritrakoon, Aree Thayananuphat, Tikamporn Teekasang, Burin Nimsuphan

ObjectivesThis study evaluated the therapeutic effects of subconjunctival injection of mesenchymal stem cells (MSCs) for treating deep corneal ulcers and corneal perforation in cats.MethodsOf the 24 cats identified with a deep corneal ulcer or perforation, 17 received MSCs and medical treatment, of which six had deep corneal ulcers and 11 had corneal perforations. Of the seven cats that received only medical treatment, three cats had deep corneal ulcer and the other four cats had corneal perforation. All were monitored with fluorescein staining at 3-4 days and weekly assessments post-MSC injection until fluorescein-negative status was achieved.ResultsOutcomes were compared between cats treated with subconjunctival MSC injections and MSC-untreated cats. Based on the results, 88% (15/17) of the cats treated with MSCs became fluorescein-negative within 1-3 weeks, whereas 12% (2/17) of those receiving subconjunctival MSC injections achieved this outcome within 5-6 weeks. During follow-up period of 146 ± 138 days (range: 15-398 days) after MSC injection, recurrence of corneal perforations was observed in four cats which were ultimately complete healed. All deep corneal ulcers were healed uneventful. In the MSC-untreated group, 57% (4/7) achieved fluorescein-negative status within 3-7 weeks, while another 29% (2/7) experienced recurrent corneal perforation on days 3 and 58, requiring conjunctival graft surgery. Post-surgery, fluorescein-negative status was achieved 25 and 72 days after the initial treatment, respectively. One cat, 14% (1/7), had recurrent corneal perforation that had healed on day 103.Conclusions and relevanceThese findings highlighted the potential of MSC therapy in promoting corneal ulcer and corneal perforation healing in cats.

目的评价结膜下注射间充质干细胞(MSCs)治疗猫角膜深部溃疡和角膜穿孔的疗效。方法对24只确诊为角膜深部溃疡或穿孔的猫,17只接受骨髓间充质干细胞治疗,其中角膜深部溃疡6只,角膜深部穿孔11只。在只接受药物治疗的7只猫中,有3只猫患有深度角膜溃疡,另外4只猫患有角膜穿孔。所有患者在注射msc后3-4天进行荧光素染色监测,并每周进行评估,直到达到荧光素阴性状态。结果比较了结膜下MSC注射治疗的猫和未治疗的猫的结果。根据结果,88%(15/17)接受MSC治疗的猫在1-3周内变成了荧光素阴性,而12%(2/17)接受结膜下MSC注射的猫在5-6周内达到了这一结果。在注射MSC后146±138天(15-398天)的随访期间,观察到4只猫角膜穿孔复发,最终完全愈合。所有角膜深部溃疡均顺利愈合。在msc未治疗组中,57%(4/7)的患者在3-7周内达到荧光素阴性状态,另有29%(2/7)的患者在第3天和第58天出现复发性角膜穿孔,需要进行结膜移植手术。术后,在初始治疗后25天和72天分别达到荧光素阴性状态。1只猫,14%(1/7)有复发性角膜穿孔,在103天愈合。这些发现强调了MSC治疗在促进猫角膜溃疡和角膜穿孔愈合方面的潜力。
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引用次数: 0
Surgical site infection after gastrointestinal surgery in cats: a retrospective single-centre analysis. 猫胃肠手术后手术部位感染的回顾性单中心分析。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-02-01 Epub Date: 2025-12-05 DOI: 10.1177/1098612X251408194
Irina Guntersweiler, Mirja C Nolff

ObjectivesThe goal of this study was to describe the incidence of surgical site infections (SSIs) in a large feline population undergoing gastrointestinal (GI) surgery and to identify factors associated with the development of SSIs specific to GI surgeries in cats, with a special focus on the usage of peri- and postoperative antibiotic treatment.MethodsMedical records of cats undergoing GI surgeries were retrospectively analysed. Data collected included demographic data, type of surgery, indication, data from the anaesthesia protocol, antibiotic use and postoperative outcome. A multivariable logistic regression model was used to identify factors associated with SSI.ResultsOf the 188 included patients undergoing GI surgery, 20 (10.6%) developed an SSI. Of these, 11 (55%) were classified as superficial incisional infections, four (20%) as deep incisional infections and five (25%) as organ/space infections. The absence of perioperative prophylactic antibiotic (PPA) administration was associated with the highest SSI rate (52.4%, 11/21), whereas significantly lower rates were observed in patients receiving PPAs alone (6.7%, 7/105), extended PPAs (7.1%, 1/14) or PPAs followed by continued antibiotic treatment (2.1%, 1/48). Prolonged antibiotic use after surgery in otherwise healthy animals showed no additional benefit in reducing SSI rates.Conclusions and relevanceWe found that PPA administration was associated with a significantly lower incidence of SSI in cats undergoing GI surgery, while extended PPA use was not associated with an additional benefit. These findings provide important guidance for evidence-based antibiotic use in feline soft tissue surgery and support efforts to minimise unnecessary antibiotic administration.

目的本研究的目的是描述大量接受胃肠(GI)手术的猫的手术部位感染(ssi)的发生率,并确定与胃肠手术特异性猫的ssi发展相关的因素,特别关注围手术期和术后抗生素治疗的使用。收集的数据包括人口统计数据、手术类型、指征、麻醉方案数据、抗生素使用和术后结果。采用多变量logistic回归模型确定与SSI相关的因素。结果188例接受胃肠道手术的患者中,20例(10.6%)发生SSI。其中,11例(55%)为浅表切口感染,4例(20%)为深切口感染,5例(25%)为器官/间隙感染。围手术期未给予预防性抗生素(PPA)与SSI发生率最高相关(52.4%,11/21),而单独接受PPA(6.7%, 7/105)、延长PPA(7.1%, 1/14)或PPA后继续抗生素治疗(2.1%,1/48)的患者SSI发生率明显较低。在其他健康的动物手术后长期使用抗生素在降低SSI发生率方面没有额外的好处。结论和相关性我们发现,PPA给药与接受GI手术的猫的SSI发生率显著降低相关,而延长PPA使用与额外的益处无关。这些发现为在猫软组织手术中使用基于证据的抗生素提供了重要指导,并支持努力减少不必要的抗生素使用。
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引用次数: 0
EXPRESS: Surgical treatment of feline meningioma: a single institution survival analysis. 猫脑膜瘤的手术治疗:单机构生存分析。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-01-30 DOI: 10.1177/1098612X261421991
Kathelijn Justine van Heusden, Lucinda L van Stee, Niels Blees, Wilhelmina Bergmann, Carles Planas Padrós, Björn Meij

Case series summaryThe aim of this study was to evaluate survival time (MST), disease-free interval (DFI), and post-operative complications of surgical resection of feline intracranial meningiomas, providing evidence for prognostic counselling for general practitioners. A retrospective review of medical records (2012-2025) identified 17 cats undergoing craniotomy or craniectomy for histologically confirmed meningiomas. Data included patient characteristics, clinical signs, imaging findings, surgical approach, complications, histopathology, recurrence and survival. MRI or CT imaging was used for diagnosis and post-operative monitoring when available. Survival analysis employed Kaplan-Meier and competing risk models; DFI was based on clinical signs or follow-up imaging.Seventeen cats (median age 11.6 years; 82.4% Domestic Shorthair) underwent surgery. Rostrotentorial approach was most common (65%), with minor intraoperative complications in three cases. Post-operative mortality within 4 weeks after surgery was 17.6% (3/17). Fourteen cats survived to discharge. Median follow-up was 622 days. Estimated median survival time was 1674 days (95% CI: 1395-NE (not estimable)), with one-, two-, three-, and four-year survival rates of 82%, 82%, 82%, and 72%, respectively. Median DFI was 377 days (855 days for cats surviving to discharge). Histopathology predominantly included meningothelial and transitional subtypes. Recurrence was detected on MRI in 3/6 cases undergoing follow-up imaging.Relevance and Novel InformationSurgical resection of feline meningiomas is a feasible treatment option with excellent outcomes for cats surviving the immediate post-operative period. The study demonstrates a high median survival time and low recurrence rate among treated cats, with surgery being curative in many cases. These results enable the veterinary general practitioner to more accurately assess the risks and benefits of surgical treatment of feline intra-cranial meningioma and discuss treatment with owners.

本研究的目的是评估猫颅内脑膜瘤手术切除的生存时间(MST)、无病间隔(DFI)和术后并发症,为全科医生的预后咨询提供依据。对2012-2025年的医疗记录进行回顾性回顾,发现17只猫因组织学证实的脑膜瘤而接受开颅或开颅手术。资料包括患者特征、临床体征、影像学表现、手术入路、并发症、组织病理学、复发和生存。MRI或CT成像用于诊断和术后监测。生存分析采用Kaplan-Meier模型和竞争风险模型;DFI是基于临床体征或随访影像。17只猫(中位年龄11.6岁;82.4%家养短毛猫)接受了手术。前幕入路最常见(65%),3例伴有轻微术中并发症。术后4周内死亡率为17.6%(3/17)。14只猫活下来出院了。中位随访时间为622天。估计中位生存时间为1674天(95% CI: 1395-NE(不可估计)),1年、2年、3年和4年生存率分别为82%、82%、82%和72%。中位DFI为377天(存活至出院的猫为855天)。组织病理学主要包括脑膜上皮亚型和移行亚型。随访的病例中,有3/6在MRI上发现复发。手术切除猫脑膜瘤是一种可行的治疗选择,对于术后存活的猫来说效果很好。该研究表明,接受治疗的猫有较高的中位生存时间和较低的复发率,在许多情况下,手术可以治愈。这些结果使兽医全科医生能够更准确地评估手术治疗猫脑内脑膜瘤的风险和收益,并与业主讨论治疗方法。
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引用次数: 0
EXPRESS: Evaluation of the Degradation Profile of Biodegradable Polymers in a Dynamic In Vitro Model with Artificial Feline Urine. EXPRESS:评价生物可降解聚合物在人工猫尿动态体外模型中的降解特征。
IF 2.1 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2026-01-21 DOI: 10.1177/1098612X261418750
Daiana Cardoso, João Requicha, André Meneses, Margarida Pacheco, Alexandre Barros

Objective: To evaluate the degradation profiles and mechanical properties of three absorbable polymers-poly(glycolide-co-trimethylene carbonate-co-epsilon-caprolactone) (PGTC), poly-p-dioxanone (PDO), and poly(glycolide-co-epsilon-caprolactone) (PGC)-envisioning the development of biodegradable ureteral stents in feline medicine.

Methods: PGC, PGTC, and PDO samples were exposed to artificial feline urine circulated through a dynamic system replicating ureteral flow at 38 °C for eight weeks. Degradation was evaluated through weekly measurements of mass loss and qualitative changes. Tensile strength, strain, and stiffness were assessed at defined intervals (day 0, weeks 4, 6, and 7).

Results: PGC degraded completely by week 6, showing rapid loss of tensile strength but consistent stiffness. PGTC exhibited gradual degradation and loss of manageability by week 8, with surface flaking visible microscopically. PDO did not fragment during manipulation or circulation, maintaining tensile strength over eight weeks, although stiffness fluctuations and brittleness were observed.

Conclusion: The polymers showed distinct degradation and mechanical behaviors, providing options for different clinical scenarios. PGC, with rapid degradation, may suit short-term applications. PGTC, with gradual degradation and consistent mechanical properties, could serve intermediate applications. PDO, with slower degradation and prolonged tensile strength, appears suitable for longer-term use. These findings represent a step toward developing biodegradable ureteral stents for feline use, potentially simplifying postoperative management and avoiding stent removal.

Relevance: Biodegradable ureteral stents may improve the management of feline ureteral obstructions by eliminating secondary removal procedures. In this in vitro dynamic model, the polymers degraded in a controlled and predictable manner, without accumulation of debris or flow obstruction in the in vitro system. Future studies should assess whether similar behavior occurs in smaller tubular structures similar to the feline ureter.

目的:评价聚乙二醇-共三亚甲基碳酸-共epsilon-己内酯(PGTC)、聚对二氧环酮(PDO)和聚乙二醇-共epsilon-己内酯(PGC)三种可吸收聚合物的降解特征和力学性能,为开发可生物降解的猫药输尿管支架奠定基础。方法:将PGC、PGTC和PDO样品暴露于人工猫尿中,在38℃的动态系统中复制输尿管流动,持续8周。降解是通过每周测量质量损失和质变来评估的。在规定的时间间隔(第0天、第4周、第6周和第7周)评估抗拉强度、应变和刚度。结果:PGC在第6周完全降解,抗拉强度迅速下降,但刚度保持一致。到第8周,PGTC逐渐退化,失去可管理性,显微镜下可以看到表面剥落。PDO在操作或循环过程中没有碎裂,尽管观察到刚度波动和脆性,但在八周内保持抗拉强度。结论:该聚合物具有明显的降解和力学行为,可用于不同的临床应用。PGC降解快,适合短期应用。PGTC具有逐渐降解和稳定的力学性能,可用于中间应用。PDO具有较慢的降解和延长的抗拉强度,似乎适合长期使用。这些发现代表了开发用于猫的可生物降解输尿管支架的一步,可能简化术后管理并避免支架移除。相关性:可生物降解输尿管支架可以通过消除二次切除手术来改善猫输尿管梗阻的治疗。在这个体外动态模型中,聚合物以可控和可预测的方式降解,在体外系统中没有碎屑积累或流动阻塞。未来的研究应该评估类似于猫输尿管的更小的管状结构是否也会发生类似的行为。
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引用次数: 0
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Journal of Feline Medicine and Surgery
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