Journal of gynecology obstetrics and human reproduction最新文献

{"title":"Experience in medical treatment of ectopic pregnancy, cesarean scar with three comparative methods: Methotrexate intra-gestational-sac injection, ultrasound-guided KCL injection, and hysteroscopy-assisted resection","authors":"Nazli Navali ,&nbsp;Saeedeh Mardi ,&nbsp;Solmaz Fallahi","doi":"10.1016/j.jogoh.2025.103056","DOIUrl":"10.1016/j.jogoh.2025.103056","url":null,"abstract":"<div><h3>Introduction</h3><div>Cesarean scar pregnancy (CSP) presents significant risks to the mother, and there is no consensus on the optimal treatment for this condition. This study was conducted to compare the effectiveness of three interventions: methotrexate (MTX) intra-gestational sac injection, potassium chloride (KCL) intra-gestational sac injection under ultrasound guidance, and hysteroscopic resection.</div></div><div><h3>Methods</h3><div>Women with CSP were enrolled and randomly assigned to three groups: (1) MTX injection with curettage, (2) KCl injection with curettage, and (3) hysteroscopic resection performed one day after intramuscular MTX administration. Discharge was scheduled for the following day, provided there were no complications. Weekly follow-up assessments included measuring serum β-human chorionic gonadotropin (β-hCG) levels.</div></div><div><h3>Results</h3><div>No statistically significant differences were observed in serum β-hCG levels among the groups before treatment or after intervention (p-value=0.396 and p-value=0.095, respectively). The length of hospitalization did not differ significantly between the groups (<em>p</em> = 0.903). Similarly, the time to β-hCG normalization showed no significant variation (p = 0.426). All three treatment strategies effectively achieved complete resolution, with a marked decline in serum β-hCG levels across all participants.</div></div><div><h3>Conclusion</h3><div>The comparative analysis indicates equivalent efficacy among the three interventions in terms of gestational sac resolution and β-hCG clearance time. No cases of uterine perforation, hemorrhage, hysterectomy, or extended hospitalization were reported following any of the treatments.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 1","pages":"Article 103056"},"PeriodicalIF":1.6,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbidity of surgical induced abortion between 14 and 16 weeks of gestation","authors":"Aurélie Jugnet ,&nbsp;Lise Amart ,&nbsp;Hamza Benjelloun ,&nbsp;Mathilde Gibier ,&nbsp;Claire Burnet ,&nbsp;Héléne Piclet ,&nbsp;Aubert Agostini","doi":"10.1016/j.jogoh.2025.103055","DOIUrl":"10.1016/j.jogoh.2025.103055","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the morbidity associated with surgical induced abortion (SIA) using the dilation and evacuation (D&amp;E) technique between 14 and 16 weeks of gestation (WG).</div></div><div><h3>Material and Methods</h3><div>A retrospective single-center cohort study was conducted at Hôpital de la Conception, Marseille, including patients who underwent SIA between 14 and 16 WG from April 4, 2022, to February 8, 2024.</div></div><div><h3>Results</h3><div>Among the 127 patients included, 17 cases (13.39%) of haemorrhage (blood loss &gt; 500 mL) were reported, 1 case (0.79%) required a hemostatic hysterectomy and a blood transfusion due to placenta accreta, 2 cases (1.57%) involved cervical lacerations, and 2 cases (1.57%) postoperative infections. No uterine perforations or secondary surgeries for retained products were reported. Blood loss volume decreased over the course of the study (beta -0.55; 95% CI -0.79, -0.30; <em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>SIA using the D&amp;E method between 14 and 16 WG is a procedure with a low risk of major complications. As with any surgical procedure, this technique requires a learning curve.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103055"},"PeriodicalIF":1.6,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal monitoring in pregnancies at and beyond 41 completed weeks: Prospective blind observational study of the use of umbilical and middle cerebral artery Doppler","authors":"Jeremy Boujenah,&nbsp;Bernard Benoit,&nbsp;Reda Djafer,&nbsp;Jacques Raiga,&nbsp;Guillaume Benoist,&nbsp;Bruno Carbonne","doi":"10.1016/j.jogoh.2025.103054","DOIUrl":"10.1016/j.jogoh.2025.103054","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess the association of umbilical and middle cerebral artery Doppler, with the need for medical intervention during labor and the occurrence of adverse neonatal outcome in pregnancies at/or beyond 41 weeks.</div></div><div><h3>Methods</h3><div>Prospective, observational study of all pregnant women at 41 weeks and beyond during one year in a single Maternity Unit. Doppler measurements of umbilical artery and middle cerebral artery resistance indices (UA-RI and MCA-RI) and cerebro placental ratio (CPR) were performed at 41 weeks, blinded to the clinical staff. Clinical management of prolonged pregnancy was based on routine antepartum fetal heart rate (FHR) monitoring and ultrasound assessment of oligohydramnios. The main outcome measures were 2 composite criteria: 1) “medical intervention during labor” including any of cesarean delivery for FHR abnormalities and/or need for fetal scalp blood sampling for lactate measurement; and 2) “suboptimal neonatal outcome” including any of 5-min Apgar score &lt; 7, umbilical cord artery pH &lt; 7.15, transfer to neonatal unit or perinatal death. The association between abnormal fetal Doppler and the outcome criteria was assessed.</div></div><div><h3>Results</h3><div>Out of 116 women recruited (12.3 % of all deliveries), 30 (25.9 %) had a medical intervention during labor and 16 (13.8 %) had a suboptimal neonatal outcome. None of antepartum FHR or oligohydramnios were associated with any of the primary outcomes. UA-RI and cerebro-placental ratio were strongly associated with the need for a medical intervention during labor (OR [95 % CI] 13.1 [1.4 – 122.2] and 5.1 [1.3 19.7], respectively) but not with the occurrence or a suboptimal neonatal outcome. If made available to the clinical staff, abnormal fetal Dopplers could have led to 12 additional inductions of labor and to the adequate identification of 13 interventions during labor including 6 cesareans for abnormal FHR.</div></div><div><h3>Conclusion</h3><div>Abnormal fetal Doppler beyond 41 weeks may help to better identify situations at risk for medical intervention for fetal concern during labor. Further studies are necessary to assess its prospective use for the management of prolonged pregnancies</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 1","pages":"Article 103054"},"PeriodicalIF":1.6,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Impact of a national public health plan on the time frame for moderate and severe endometriosis diagnosis\"","authors":"Ruihang Luo ,&nbsp;Maosen Liu ,&nbsp;Wei Zhong ,&nbsp;Jian Bo Wu ,&nbsp;Yuxin Fan ,&nbsp;Mingshan Liu","doi":"10.1016/j.jogoh.2025.103048","DOIUrl":"10.1016/j.jogoh.2025.103048","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103048"},"PeriodicalIF":1.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with mode of delivery in large-for-gestational-age fetuses: A retrospective cohort study","authors":"Salomé Azeroual,&nbsp;Mohamed Dakin,&nbsp;Théo Joannes,&nbsp;Olivier Graesslin,&nbsp;René Gabriel,&nbsp;Benjamin Birene","doi":"10.1016/j.jogoh.2025.103047","DOIUrl":"10.1016/j.jogoh.2025.103047","url":null,"abstract":"<div><h3>Background</h3><div>Large-for-gestational-age (LGA) fetuses are often associated with increased maternal and neonatal morbidity. Although suspicion of LGA can prompt closer surveillance and interventions such as labor induction, the actual impact on delivery outcomes and complications remains controversial.</div></div><div><h3>Purpose</h3><div>To assess maternal and fetal factors associated with the mode of delivery in pregnancies with LGA fetuses.</div></div><div><h3>Basic procedures</h3><div>Retrospective, single-center study (2018–2021) including term, singleton pregnancies with birthweight ≥ 90th percentile (AUDIPOG). Exclusion criteria were prior cesarean, multiples, preterm birth, non-cephalic presentation, planned cesarean, maternal request, or incomplete records. Primary outcome was mode of delivery. Multiple logistic regression was used.</div></div><div><h3>Main findings</h3><div>A total of 211 women met inclusion criteria. The rate of operative delivery (cesarean or instrumental vaginal birth) was 32.2% (68/211). In multiple logistic regression, nulliparity (OR 8.1, 95% CI 3.2–20.5, <em>p</em> &lt; 0.001), induction of labor (OR 2.6, 95% CI 1.1–6.3, <em>p</em> = 0.035), greater gestational weight gain (OR 1.07 per kg, 95% CI 1.01–1.14, <em>p</em> = 0.021), and prenatal suspicion of macrosomia (EFW &gt; 90th percentile at growth or third-trimester ultrasound, OR 2.9, 95% CI 1.2–7.1, <em>p</em> = 0.019) were independently associated with an increased risk of non-spontaneous birth. Maternal age, diabetes, and a history of LGA were not significantly associated after adjustment. Neonatal outcomes were favorable, with only one case of umbilical arterial pH &lt; 7.00 (0.5%) and no severe traumatic complications.</div></div><div><h3>Conclusions</h3><div>In LGA pregnancies, nulliparity and suspected macrosomia were associated with higher rates of medical intervention, whereas induction and prior vaginal delivery favored spontaneous birth. Neonatal weight did not differ between delivery modes. These findings underscore the complexity of managing suspected LGA fetuses and the need for prospective multicenter studies to refine risk stratification.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103047"},"PeriodicalIF":1.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of GLP-1 receptor agonists in obstetrics and perinatal outcomes: A systematic review and meta-analysis","authors":"Bruna Benigna Sales Armstrong ,&nbsp;Ana Clara Pimenta Servidoni ,&nbsp;Giovanna Cristina de Castro Martin ,&nbsp;Guilherme Franceschini Machado ,&nbsp;Wellgner Fernandes Oliveira Amador ,&nbsp;Abdelrahman Yousif","doi":"10.1016/j.jogoh.2025.103046","DOIUrl":"10.1016/j.jogoh.2025.103046","url":null,"abstract":"<div><h3>Objective</h3><div>Primary endpoint is maternal and fetal complications during pregnancy, labor, and delivery after exposure to GLP-1 receptor agonists.</div></div><div><h3>Data Sources</h3><div>A systematic search was conducted across PubMed, Embase, and Cochrane Central databases, including studies published from 2020 to 2025.</div></div><div><h3>Study eligibility criteria</h3><div>Included studies: (1) RCTs or cohorts; (2) exposure to GLP-1 RAs during pregnancy or preconception; (3) control group not exposed to GLP-1 RAs. Excluded studies: (1) without outcomes of interest; (2) lacking data transparency; (3) retracted; (4) abstracts, case reports, reviews; (5) no control group.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>Six studies evaluated GLP-1 RA exposure during preconception or first trimester. Two authors screened studies; a third resolved disagreements. Risk of bias was assessed with ROBINS-I and RoB 2. Meta-analysis pooled continuous outcomes with mean differences and binary outcomes with odds ratios. Heterogeneity was evaluated via Cochrane Q and I². Subgroup analysis focused on first-trimester exposure.</div></div><div><h3>Results</h3><div>No statistically significant differences in pregnancy outcomes between GLP-1 RA and control group, including fetal growth restriction or small for gestational age (<em>p</em> = 0.12), live births (<em>p</em> = 0.10), major birth defects (<em>p</em> = 0.79), miscarriages (<em>p</em> = 0.41), preterm delivery (<em>p</em> = 0.62); and stillbirths (<em>p</em> = 0.09). GLP-1 RAs were linked to a lower risk of congenital heart defects (<em>p</em> = 0.03), even in the subgroup analysis (<em>p</em> = 0.03), and showed no significant protective effect against gestational diabetes (<em>p</em> = 0.49). In subgroup analysis, there were no notable differences in miscarriage (<em>p</em> = 0.32), major birth defects (<em>p</em> = 0.83) and preterm delivery (<em>p</em> = 0.88); there were fewer live births that did not reach statistical significance (<em>p</em> = 0.06).</div></div><div><h3>Conclusion</h3><div>No statistically significant difference was observed between the control and intervention groups. GLP-1 RAs were connected to a lower risk of congenital heart defects.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103046"},"PeriodicalIF":1.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Favorable pregnancy outcome in a woman with extensive disseminated peritoneal leiomyomatosis","authors":"E. Hagelauer ,&nbsp;M. Beck ,&nbsp;C. Rousset-Jablonski ,&nbsp;E. Ruaux ,&nbsp;A. Trecourt ,&nbsp;P. Rousset ,&nbsp;W. Gertych","doi":"10.1016/j.jogoh.2025.103045","DOIUrl":"10.1016/j.jogoh.2025.103045","url":null,"abstract":"<div><div>Disseminated peritoneal leiomyomatosis (DPL) is a rare and benign condition characterized by the progression of smooth muscle tumors across the peritoneal cavity. The etiology is not well understood and could include previous surgeries and hormonal stimulation. We report on a 39-year-old woman with extensive DPL at the end of her pregnancy. She was diagnosed in the context of amenorrhea and was initially treated by gonadotropin-releasing hormone (GnRH) agonist. During pregnancy, a significant increase in lesion size was observed. The day before the planned cesarean-section (C-section), she presented with severe hypercalcemia, which was probably from a paraneoplastic origin. The patient underwent a planned C-section at 36 weeks and 5 days of gestation by midline sub-umbilical laparotomy, allowing a safe delivery.</div><div>This case provides insights for healthcare providers facing similar cases, considering that the obstetrical management of patients with DPL has not yet been defined.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103045"},"PeriodicalIF":1.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Follow-Up in young women with severe dysmenorrhea predicts early onset of endometriosis.","authors":"Elvira Nocita, Francesco Giuseppe Martire, Chiara Paladino, Giulia Monaco, Federica Iacobini, Sara Valeriani, Giorgia Soreca, Consuelo Russo, Caterina Exacoustos","doi":"10.1016/j.jogoh.2025.103003","DOIUrl":"10.1016/j.jogoh.2025.103003","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the progression of endometriosis and painful symptoms in young women (≤ 25 years) with severe dysmenorrhea (Visual Analogue Scale score ≥ 7), with or without ultrasound-detected endometriosis, over a follow-up period of 12 to 36 months. The impact of hormone therapy was also assessed.</p><p><strong>Methods: </strong>This retrospective observational study included 124 young women with severe dysmenorrhea: 67 had ultrasound signs of endometriosis/adenomyosis, 57 did not. All patients with ultrasound-detected endometriosis/adenomyosis received continuous hormone therapy, inducing amenorrhea; those without ultrasound findings underwent either cyclic hormone therapy or no treatment. Clinical and ultrasound assessments were performed at baseline and at follow-up visits at 12, 24 and 36 months, recording all symptoms and disease sites.</p><p><strong>Results: </strong>In patients with ultrasound-detected endometriosis on continuous hormone therapy, all painful symptoms improved, and endometrioma size significantly decreased, with 40 % resolving completely. Utero-sacral ligament lesions also shrank, while rectal endometriosis remained unchanged. Ultrasound direct signs of adenomyosis were no longer visible in 22 % of cases. In patients without initial ultrasound evidence of endometriosis and with a regular menstrual cycle, new ultrasound-detected endometriosis emerged in 20 % of cases at follow-up.</p><p><strong>Conclusions: </strong>In young patients with severe dysmenorrhea, clinical and ultrasound follow-up supports early detection of endometriosis and an appropriate treatment may reduce symptoms and prevent disease progression.</p>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":" ","pages":"103003"},"PeriodicalIF":1.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What changes in the fetal heart rate are associated with neonatal acidosis during the second stage of labor?","authors":"G. Dhenin ,&nbsp;S. Godin ,&nbsp;N. Ramdane ,&nbsp;H. Behal ,&nbsp;C. Garabedian","doi":"10.1016/j.jogoh.2025.103043","DOIUrl":"10.1016/j.jogoh.2025.103043","url":null,"abstract":"<div><h3>Objective</h3><div>To describe fetal heart rate (FHR) patterns associated with neonatal acidosis during the second stage of labor.</div></div><div><h3>Method</h3><div>This single-center (Lille, France) retrospective cohort study was conducted between September 2022 and January 2023. Fetal heart rate (FHR) during maternal expulsive efforts was interpreted for all low-risk women who delivered vaginally after 37 weeks' gestation. Low risk was defined by the absence of any maternal history, obstetric complications, and a normal fetal heart rate in the hour before the onset of expulsive efforts. A baseline increase was defined as a greater than 20 % increase in baseline FHR. Reduced variability and marked variability were defined as a variability &lt;5 bpm and greater than 25 bpm, respectively. FHRs were also described according to Melchior's classification. Neonatal acidosis was defined as umbilical artery pH &lt;7.15.</div></div><div><h3>Results</h3><div>Among the 275 expulsion FHRs analysed, 7.3 % (20/275) showed increased baseline and 5.5 % (15/275) abnormal variability. Neonatal acidosis occurred in 19.6 % (54/275) of neonates. Increased baseline and bradycardia were significantly associated with neonatal acidosis (14.8 % vs 5.4 %, <em>p</em> = 0.035 and 20.4 % vs 10.0 %, <em>p</em> = 0.035, respectively).</div></div><div><h3>Conclusion</h3><div>Increased baseline fetal heart rate during the second stage of labor was associated with a significant risk of neonatal acidosis. It would be interesting to include it in classifications related to this stage.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103043"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hyperhomocysteinemia with IVF live birth rate: A retrospective cohort study","authors":"Lijun Shui ,&nbsp;Xiaozhu Chen ,&nbsp;Xianchao Dou ,&nbsp;Liangyi Ni ,&nbsp;Chao Chen ,&nbsp;Xinyi Zhu ,&nbsp;Qi Jin ,&nbsp;Shun Bai ,&nbsp;Limin Wu ,&nbsp;Meihong Hu","doi":"10.1016/j.jogoh.2025.103044","DOIUrl":"10.1016/j.jogoh.2025.103044","url":null,"abstract":"<div><h3>Objective</h3><div>Homocysteine (Hcy) has been reported to be associated with female reproduction. However, the correlation between hyperhomocysteinemia (HHcy) and pregnancy outcomes among infertile women remains unclear. This observational study aims to evaluate the effect of HHcy on pregnancy outcomes in infertile patients undergoing ART treatment.</div></div><div><h3>Methods</h3><div>Data were collected from 385 patients (50 in the HHcy group and 335 in the non-HHcy group) who underwent In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) at the First Affiliated Hospital of University of Science and Technology of China. Clinical outcomes between the two groups were analyzed.</div></div><div><h3>Results</h3><div>The number of oocytes retrieved, MII oocytes, oocyte maturation rate and normal fertilization rate did not differ significantly between the two groups. However, the HHcy group exhibited significantly lower rates of biochemical pregnancy (48 % vs. 74.9 %), clinical pregnancy (38 % vs. 63.9 %) and live births (34 % vs. 52.8 %) in the HHcy group compared to non-HHcy group. Logistic regression analyses indicated that HHcy was negatively associated with biochemical pregnancy rate (OR= 0.28, 95 % CI: 0.14–0.54, <em>P</em> &lt; 0.001), clinical pregnancy rate (OR = 0.32, 95 % CI: 0.16–0.61, <em>P</em> &lt; 0.001) and live birth rate (OR = 0.45, 95 % CI: 0.23–0.86, <em>P</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>HHcy exhibited a negative correlation with live birth among patients underwent IVF/ICSI. Clinicians should consider focusing more attention on patients with HHcy to enhance ART outcomes.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"54 10","pages":"Article 103044"},"PeriodicalIF":1.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}