Pub Date : 2026-01-06DOI: 10.1016/j.jogoh.2026.103106
D Serfaty , J Escola , L Klein , CPJ Talbot , L Longfier , F Carrois
Introduction
In France, contraception use is lowest among women aged 40 and over, and the abortion rate in this age group remains stable or slightly increases. This may be due to conventional contraceptive methods being unsuitable for these women, who are less fertile and often less sexually active. On-demand contraceptive methods include male and female condoms, diaphragms, pericoital pills and spermicides. While these methods are not currently recommended due to lower effectiveness compared to continuous contraception, they may be appropriate for women in their later reproductive years, given their reduced pregnancy risk. The IPSOS survey assessed women's contraceptive preferences, particularly for continuous versus on-demand methods.
Material and methods
A 10-minute online survey was taken by 900 women (300 from France, 300 from Algeria and 300 from Russia), randomly drawn from Ipsos database in February 2023. Half were aged between 18 and 39 and half between 40 and 50. Statistical analysis was performed on unweighted samples, the sample size insuring robustness.
Results
Overall, 63 % of women were open to on-demand contraception. Among those aged 40 and over (n = 450), 59 % favored it, with country-specific variations (49 % in France, 55 % in Algeria, and 73 % in Russia).
Discussion
This international study highlights the need for an on-demand contraception, particularly for women over 40. Combining it with continuous contraception could reduce the number of unplanned pregnancies and abortions, whose current rate in France is the highest since 1990.
{"title":"Which would you prefer: continuous or only on-demand contraception? International survey by IPSOS","authors":"D Serfaty , J Escola , L Klein , CPJ Talbot , L Longfier , F Carrois","doi":"10.1016/j.jogoh.2026.103106","DOIUrl":"10.1016/j.jogoh.2026.103106","url":null,"abstract":"<div><h3>Introduction</h3><div>In France, contraception use is lowest among women aged 40 and over, and the abortion rate in this age group remains stable or slightly increases. This may be due to conventional contraceptive methods being unsuitable for these women, who are less fertile and often less sexually active. On-demand contraceptive methods include male and female condoms, diaphragms, pericoital pills and spermicides. While these methods are not currently recommended due to lower effectiveness compared to continuous contraception, they may be appropriate for women in their later reproductive years, given their reduced pregnancy risk. The IPSOS survey assessed women's contraceptive preferences, particularly for continuous <em>versus</em> on-demand methods.</div></div><div><h3>Material and methods</h3><div>A 10-minute online survey was taken by 900 women (300 from France, 300 from Algeria and 300 from Russia), randomly drawn from Ipsos database in February 2023. Half were aged between 18 and 39 and half between 40 and 50. Statistical analysis was performed on unweighted samples, the sample size insuring robustness.</div></div><div><h3>Results</h3><div>Overall, 63 % of women were open to on-demand contraception. Among those aged 40 and over (<em>n</em> = 450), 59 % favored it, with country-specific variations (49 % in France, 55 % in Algeria, and 73 % in Russia).</div></div><div><h3>Discussion</h3><div>This international study highlights the need for an on-demand contraception, particularly for women over 40. Combining it with continuous contraception could reduce the number of unplanned pregnancies and abortions, whose current rate in France is the highest since 1990.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103106"},"PeriodicalIF":1.6,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To assess the benefit of secondary cytoreductive surgery (SCS) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC), and to evaluate how survival outcomes are influenced by second-line PARP inhibitor maintenance therapy.
Methods
This retrospective study included 52 patients with platinum-sensitive recurrent EOC treated at the National Cancer Institute of Aviano, Italy, between 2015 and 2022. Patients received either SCS followed by chemotherapy (SCS+CT group) or chemotherapy alone (CT-only group). The primary endpoints were progression-free survival (PFS) and post-recurrence survival (PRS). Secondary analyses explored the impact of second-line PARPi maintenance on survival outcomes within each treatment group.
Results
Patients in the SCS+CT group experienced significantly longer PFS compared to those in the CT-only group (median 19.2 vs. 10.0 months, p=0.007). Among patients receiving PARPi maintenance, the benefit was even more pronounced: median PFS was 40.3 months in the SCS+CT group versus 21.9 months in the CT-only group (p=0.026). A non-significant trend toward improved PRS was observed in the SCS+CT group (48.3 vs. 36.0 months, p=0.23). PARPi maintenance was associated with longer PRS in both treatment arms (p=0.0056 for SCS+CT; p=0.033 for CT-only).
Conclusions
In patients with platinum-sensitive recurrent EOC, SCS combined with chemotherapy significantly improves PFS, particularly when followed by second-line PARPi maintenance. These findings support the role of SCS in carefully selected patients and emphasize the synergistic effect of integrating surgical and molecularly targeted strategies.
{"title":"Evaluating the role of secondary surgery and PARP inhibition in platinum-sensitive ovarian cancer relapse","authors":"Stefano Fucina , Nicolò Clemente , Anna Del Fabro , Luca Martella , Emilio Lucia , Fabio Puglisi , Michele Bartoletti , Gustavo Baldassarre , Fabiola Giudici , Vincenzo Canzonieri , Antonino Ditto","doi":"10.1016/j.jogoh.2026.103108","DOIUrl":"10.1016/j.jogoh.2026.103108","url":null,"abstract":"<div><h3>Aim</h3><div>To assess the benefit of secondary cytoreductive surgery (SCS) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC), and to evaluate how survival outcomes are influenced by second-line PARP inhibitor maintenance therapy.</div></div><div><h3>Methods</h3><div>This retrospective study included 52 patients with platinum-sensitive recurrent EOC treated at the National Cancer Institute of Aviano, Italy, between 2015 and 2022. Patients received either SCS followed by chemotherapy (SCS+CT group) or chemotherapy alone (CT-only group). The primary endpoints were progression-free survival (PFS) and post-recurrence survival (PRS). Secondary analyses explored the impact of second-line PARPi maintenance on survival outcomes within each treatment group.</div></div><div><h3>Results</h3><div>Patients in the SCS+CT group experienced significantly longer PFS compared to those in the CT-only group (median 19.2 vs. 10.0 months, <em>p</em>=0.007). Among patients receiving PARPi maintenance, the benefit was even more pronounced: median PFS was 40.3 months in the SCS+CT group versus 21.9 months in the CT-only group (p=0.026). A non-significant trend toward improved PRS was observed in the SCS+CT group (48.3 vs. 36.0 months, <em>p</em>=0.23). PARPi maintenance was associated with longer PRS in both treatment arms (<em>p</em>=0.0056 for SCS+CT; p=0.033 for CT-only).</div></div><div><h3>Conclusions</h3><div>In patients with platinum-sensitive recurrent EOC, SCS combined with chemotherapy significantly improves PFS, particularly when followed by second-line PARPi maintenance. These findings support the role of SCS in carefully selected patients and emphasize the synergistic effect of integrating surgical and molecularly targeted strategies.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103108"},"PeriodicalIF":1.6,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.jogoh.2026.103107
Luc van Lonkhuijzen , Constantijne H. Mom , Maaike van der Aa
{"title":"Cervical cancer in women eligible for HPV-vaccination in the Netherlands","authors":"Luc van Lonkhuijzen , Constantijne H. Mom , Maaike van der Aa","doi":"10.1016/j.jogoh.2026.103107","DOIUrl":"10.1016/j.jogoh.2026.103107","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103107"},"PeriodicalIF":1.6,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.jogoh.2026.103105
Hélène Alleoud Michi , Hélène Hoarau , Vincent Balaya , Julie Marcadet , Malik Boukerrou , Phuong Lien Tran
{"title":"From right to reality: Barriers in women's journey to tubal sterilization","authors":"Hélène Alleoud Michi , Hélène Hoarau , Vincent Balaya , Julie Marcadet , Malik Boukerrou , Phuong Lien Tran","doi":"10.1016/j.jogoh.2026.103105","DOIUrl":"10.1016/j.jogoh.2026.103105","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103105"},"PeriodicalIF":1.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy and safety of topical anesthetics during intrauterine device insertion: A systematic review","authors":"Sylvine Carrondo Cottin , Geneviève Asselin , Mathieu Leboeuf , Marc Rhainds","doi":"10.1016/j.jogoh.2026.103104","DOIUrl":"10.1016/j.jogoh.2026.103104","url":null,"abstract":"","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103104"},"PeriodicalIF":1.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.jogoh.2025.103103
Camille Martel , Claire Zhang , Lise Lecointre , Catherine Roy , Emilie Faller , Thomas Boisramé , Luc Soler , Cherif Akladios
Background
Colorectal endometriosis (CRE) is one of the most severe forms of deep pelvic endometriosis with a high risk of major postoperative complications. While pelvic MRI is the gold standard for preoperative assessment, its interpretation remains challenging. This study aimed to evaluate the feasibility and potential clinical value of three-dimensional (3D) MRI-based modeling as a tool to support preoperative planning in patients with CRE.
Methods
All patients who underwent laparoscopic segmental rectosigmoid resection for deep endometriosis (DE) between January 1, 2008 and December 31, 2019 in the gynecologic surgery department of Hautepierre Hospital with preoperative pelvic MRI performed at the Strasbourg New Civil Hospital were retrospectively included. Segmentation was carried out by a gynecologic surgeon using VP Planning® software on T2-weighted 3D axial images. The resulting 3D models were then evaluated by four expert gynecologic surgeons using a structured questionnaire assessing anatomical accuracy and potential usefulness for surgical planning.
Results
Fourteen 3D models of the pelvic anatomy were produced. The comparison of the modeling data with operative reports was satisfactory with a good correlation of the modeling with the operative findings. The interest of modeling in surgical planning were evaluated at 7.6 / 10. Surgeons believed that 3D modeling could help them understand the complexity of the surgery in 79 % of the cases presented.
Conclusion
This study demonstrates the technical feasibility of 3D surface-based modeling of CRE using pelvic MRI. The 3D models obtained seems to have interesting potential in the context of pre operative planning.
{"title":"Feasibility and clinical value of virtual reality based on 3D model in colorectal endometriosis for surgical planning","authors":"Camille Martel , Claire Zhang , Lise Lecointre , Catherine Roy , Emilie Faller , Thomas Boisramé , Luc Soler , Cherif Akladios","doi":"10.1016/j.jogoh.2025.103103","DOIUrl":"10.1016/j.jogoh.2025.103103","url":null,"abstract":"<div><h3>Background</h3><div>Colorectal endometriosis (CRE) is one of the most severe forms of deep pelvic endometriosis with a high risk of major postoperative complications. While pelvic MRI is the gold standard for preoperative assessment, its interpretation remains challenging. This study aimed to evaluate the feasibility and potential clinical value of three-dimensional (3D) MRI-based modeling as a tool to support preoperative planning in patients with CRE.</div></div><div><h3>Methods</h3><div>All patients who underwent laparoscopic segmental rectosigmoid resection for deep endometriosis (DE) between January 1, 2008 and December 31, 2019 in the gynecologic surgery department of Hautepierre Hospital with preoperative pelvic MRI performed at the Strasbourg New Civil Hospital were retrospectively included. Segmentation was carried out by a gynecologic surgeon using VP Planning® software on T2-weighted 3D axial images. The resulting 3D models were then evaluated by four expert gynecologic surgeons using a structured questionnaire assessing anatomical accuracy and potential usefulness for surgical planning.</div></div><div><h3>Results</h3><div>Fourteen 3D models of the pelvic anatomy were produced. The comparison of the modeling data with operative reports was satisfactory with a good correlation of the modeling with the operative findings. The interest of modeling in surgical planning were evaluated at 7.6 / 10. Surgeons believed that 3D modeling could help them understand the complexity of the surgery in 79 % of the cases presented.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the technical feasibility of 3D surface-based modeling of CRE using pelvic MRI. The 3D models obtained seems to have interesting potential in the context of pre operative planning.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103103"},"PeriodicalIF":1.6,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Infertility constitutes a major public health issue, and requests for oocyte donation, initially indicated in cases of premature ovarian insufficiency or to avoid the transmission of a maternally inherited genetic disease, are currently increasing due to the rise in requests following IVF failure or in cases of age-related infertility. Pregnancies resulting from oocyte donation are associated with increased obstetric morbidity compared with spontaneous pregnancies or those resulting from IVF with autologous oocytes. However, the influence of the initial indication for oocyte donation on obstetric outcomes is still debated.
Objective
To evaluate clinical pregnancy rates and obstetric outcomes of singleton pregnancies after oocyte donation according to the maternal indication.
Materials and Methods
A retrospective single-center study including infertile women aged 18 to 43 years, managed with oocyte donation between 2012 and 2024 in our Assisted Reproductive Technology center. Clinico-biological data and the outcomes of oocyte donation cycles were analyzed. The obstetric outcomes of singleton ongoing pregnancies were studied according to the etiology of oocyte donation: group 1 (intra-couple IVF failure), group 2 (genetic cause), group 3 (idiopathic POI), group 4 (iatrogenic POI).
Results
A total of 276 women underwent 586 oocyte donation cycles, with embryo transfer performed in 88% of cases under hormone replacement therapy. The clinical pregnancy rate per cycle was 30%, significantly higher in the group 3 idiopathic POI (44.2%,). The live birth rate per cycle was 21% in the overall population and 31% in the group 3 (p = 0.014). Among the 107 singleton pregnancies resulting in live birth, the most frequent complications were gestational diabetes (23 %) and hypertensive disorders (23%), with no significant difference between the 4 groups. The overall caesarean section rate was 44%.
Conclusion
Patients with idiopathic POI achieve better pregnancy and live birth rates after oocyte donation, without a specific increase in obstetric complications compared with other indications. The increased obstetric morbidity observed after oocyte donation underlines the need for personalized pregnancy follow-up.
{"title":"Pregnancy chances and obstetrical outcomes after egg donation according to the maternal indication","authors":"Saadoun Cheina , Zimmermann Appoline , Gnisci Audrey , Deveze Carole , Guillemain-Metzler Catherine , Courbiere Blandine","doi":"10.1016/j.jogoh.2025.103102","DOIUrl":"10.1016/j.jogoh.2025.103102","url":null,"abstract":"<div><h3>Introduction</h3><div>Infertility constitutes a major public health issue, and requests for oocyte donation, initially indicated in cases of premature ovarian insufficiency or to avoid the transmission of a maternally inherited genetic disease, are currently increasing due to the rise in requests following IVF failure or in cases of age-related infertility. Pregnancies resulting from oocyte donation are associated with increased obstetric morbidity compared with spontaneous pregnancies or those resulting from IVF with autologous oocytes. However, the influence of the initial indication for oocyte donation on obstetric outcomes is still debated.</div></div><div><h3>Objective</h3><div>To evaluate clinical pregnancy rates and obstetric outcomes of singleton pregnancies after oocyte donation according to the maternal indication.</div></div><div><h3>Materials and Methods</h3><div>A retrospective single-center study including infertile women aged 18 to 43 years, managed with oocyte donation between 2012 and 2024 in our Assisted Reproductive Technology center. Clinico-biological data and the outcomes of oocyte donation cycles were analyzed. The obstetric outcomes of singleton ongoing pregnancies were studied according to the etiology of oocyte donation: group 1 (intra-couple IVF failure), group 2 (genetic cause), group 3 (idiopathic POI), group 4 (iatrogenic POI).</div></div><div><h3>Results</h3><div>A total of 276 women underwent 586 oocyte donation cycles, with embryo transfer performed in 88% of cases under hormone replacement therapy. The clinical pregnancy rate per cycle was 30%, significantly higher in the group 3 idiopathic POI (44.2%,). The live birth rate per cycle was 21% in the overall population and 31% in the group 3 (<em>p</em> = 0.014). Among the 107 singleton pregnancies resulting in live birth, the most frequent complications were gestational diabetes (23 %) and hypertensive disorders (23%), with no significant difference between the 4 groups. The overall caesarean section rate was 44%.</div></div><div><h3>Conclusion</h3><div>Patients with idiopathic POI achieve better pregnancy and live birth rates after oocyte donation, without a specific increase in obstetric complications compared with other indications. The increased obstetric morbidity observed after oocyte donation underlines the need for personalized pregnancy follow-up.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103102"},"PeriodicalIF":1.6,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.jogoh.2025.103099
Yangyang Zhang , Pan Dou , Nuo Huang , Jiao Yu , Xi Wang , Fei Chen , Haiyu Li , Yang Xu
Background
To date, research on polycystic ovary syndrome (PCOS) has focused on patients who are overweight/obese, with less attention given to PCOS patients who have a normal body mass index (BMI). The latter may also exhibit an increased body fat percentage (BFP). Studies have shown that BFP can affect hormonal profiles, metabolism and adipokine-related indicators. Therefore, the aim of this study was to investigate the effects of BFP on the aforementioned indicators in PCOS patients with a normal BMI.
Methods
In total, 115 PCOS patients with and without a normal BMI were included in this cross-sectional cohort study. The women were divided into two groups: the high-BFP group (BFP≥30 %) and the normal-BFP group (BFP<30 %). Body composition indicators such as BFP were assessed with an Inbody770 body composition measuring instrument made by Biospace Co., Ltd. Serum hormonal profiles and glucose and lipid metabolism-related indicators were determined via biochemical assessments. Among the 115 PCOS patients with a normal BMI, 56 were tested for inflammation and adipokine-related indicators by ELISA. These indicators were analysed with a two-sided t test.
Results
The prevalence of high BFP in PCOS patients with a normal BMI was 60 %. With a waist‒to‒hip ratio ≥0.85 set as the threshold, the incidence of central obesity was 65.22 % in the high-BFP group and 19.57 % in the normal-BFP group. The LH/FSH ratio, free androgen index (FAI), and DHEAS and androstenedione levels were greater in the high-BFP group than in the normal-BFP group. On the basis of a HOMA-IR >2.69 as the diagnostic criterion for insulin resistance, no significant difference in the prevalence of insulin resistance was observed between the two groups. The blood glucose and insulin levels at 2 hours after sugar intake were greater in the high-BFP group than in the normal-BFP group. Among the lipid metabolism indicators, the triglyceride level was significantly greater and the HDL level was significantly lower in the high-BFP group than in the normal-BFP group. There were no significant differences in inflammation-related indicators between the two groups. With respect to adipokines, the leptin level was significantly higher in the high-BFP group than in the normal-BFP group. The levels of other indicators, such as adiponectin and resistin, did not differ significantly between the two groups.
Conclusions
More attention should be given to PCOS patients with a normal BMI. Our study revealed that approximately 60 % of these patients have elevated BFP. A high BFP can lead to disruptions in sex hormone levels, metabolism and adipokine levels, which may further affect pregnancy outcomes. These findings suggest that a more intense focus on body composition analysis and BFP control is needed in the diagnosis and treatment of PCOS.
{"title":"Effects of body fat percentage on hormonal profiles, metabolism and adipokine-related indicators in PCOS patients with a normal body mass index: A cross-sectional study","authors":"Yangyang Zhang , Pan Dou , Nuo Huang , Jiao Yu , Xi Wang , Fei Chen , Haiyu Li , Yang Xu","doi":"10.1016/j.jogoh.2025.103099","DOIUrl":"10.1016/j.jogoh.2025.103099","url":null,"abstract":"<div><h3>Background</h3><div>To date, research on polycystic ovary syndrome (PCOS) has focused on patients who are overweight/obese, with less attention given to PCOS patients who have a normal body mass index (BMI). The latter may also exhibit an increased body fat percentage (BFP). Studies have shown that BFP can affect hormonal profiles, metabolism and adipokine-related indicators. Therefore, the aim of this study was to investigate the effects of BFP on the aforementioned indicators in PCOS patients with a normal BMI.</div></div><div><h3>Methods</h3><div>In total, 115 PCOS patients with and without a normal BMI were included in this cross-sectional cohort study. The women were divided into two groups: the high-BFP group (BFP≥30 %) and the normal-BFP group (BFP<30 %). Body composition indicators such as BFP were assessed with an Inbody770 body composition measuring instrument made by Biospace Co., Ltd. Serum hormonal profiles and glucose and lipid metabolism-related indicators were determined via biochemical assessments. Among the 115 PCOS patients with a normal BMI, 56 were tested for inflammation and adipokine-related indicators by ELISA. These indicators were analysed with a two-sided t test.</div></div><div><h3>Results</h3><div>The prevalence of high BFP in PCOS patients with a normal BMI was 60 %. With a waist‒to‒hip ratio ≥0.85 set as the threshold, the incidence of central obesity was 65.22 % in the high-BFP group and 19.57 % in the normal-BFP group. The LH/FSH ratio, free androgen index (FAI), and DHEAS and androstenedione levels were greater in the high-BFP group than in the normal-BFP group. On the basis of a HOMA-IR >2.69 as the diagnostic criterion for insulin resistance, no significant difference in the prevalence of insulin resistance was observed between the two groups. The blood glucose and insulin levels at 2 hours after sugar intake were greater in the high-BFP group than in the normal-BFP group. Among the lipid metabolism indicators, the triglyceride level was significantly greater and the HDL level was significantly lower in the high-BFP group than in the normal-BFP group. There were no significant differences in inflammation-related indicators between the two groups. With respect to adipokines, the leptin level was significantly higher in the high-BFP group than in the normal-BFP group. The levels of other indicators, such as adiponectin and resistin, did not differ significantly between the two groups.</div></div><div><h3>Conclusions</h3><div>More attention should be given to PCOS patients with a normal BMI. Our study revealed that approximately 60 % of these patients have elevated BFP. A high BFP can lead to disruptions in sex hormone levels, metabolism and adipokine levels, which may further affect pregnancy outcomes. These findings suggest that a more intense focus on body composition analysis and BFP control is needed in the diagnosis and treatment of PCOS.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 2","pages":"Article 103099"},"PeriodicalIF":1.6,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.jogoh.2025.103101
Xi Chen , Junhong Du , Yuemei Cheng , Tingyu Lang , Xiaowei Liu , Hongli Li , Yongxiu Yang , Xiaolei Liang
Objective
The impact of adjuvant radiotherapy (aRT) on overall survival (OS) in early-stage type II endometrial carcinoma (EC) remains uncertain. This study aimed to develop nomograms and a web-based calculator to identify these patients who may benefit from aRT.
Methods
Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and divided into the developing and validation cohorts. LASSO Cox regression identified prognostic factors, and nomograms were constructed to predict 1-, 3-, and 5-year OS with/without aRT. The expected OS benefit from aRT was reflected in the difference between the two predicted OS nomograms. Validation involved ROC analysis, calibration curves, and decision curve analysis. A web calculator was created for estimating aRT's net OS benefit.
Results
Among the 6084 patients, aRT did not improve OS across all patients but showed benefits in specific subgroups, such as those with clear cell carcinoma and carcinosarcoma. Nomograms were constructed for patients with/without aRT to predict 1-, 3-, and 5-year OS, and they can accurately forecast OS. Additionally, the web-based calculator was developed to estimate the net OS benefit of aRT.
Conclusions
The nomograms provide accurate OS estimates for early-stage type II EC patients with/without aRT, thereby supporting individualized treatment decisions. The web calculator offers a quantitative tool for optimizing aRT use based on clinicopathological characteristics.
{"title":"Developing an online calculator to estimate the overall survival benefit from adjuvant radiotherapy in patients with early-stage type II endometrial carcinoma","authors":"Xi Chen , Junhong Du , Yuemei Cheng , Tingyu Lang , Xiaowei Liu , Hongli Li , Yongxiu Yang , Xiaolei Liang","doi":"10.1016/j.jogoh.2025.103101","DOIUrl":"10.1016/j.jogoh.2025.103101","url":null,"abstract":"<div><h3>Objective</h3><div>The impact of adjuvant radiotherapy (aRT) on overall survival (OS) in early-stage type II endometrial carcinoma (EC) remains uncertain. This study aimed to develop nomograms and a web-based calculator to identify these patients who may benefit from aRT.</div></div><div><h3>Methods</h3><div>Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and divided into the developing and validation cohorts. LASSO Cox regression identified prognostic factors, and nomograms were constructed to predict 1-, 3-, and 5-year OS with/without aRT. The expected OS benefit from aRT was reflected in the difference between the two predicted OS nomograms. Validation involved ROC analysis, calibration curves, and decision curve analysis. A web calculator was created for estimating aRT's net OS benefit.</div></div><div><h3>Results</h3><div>Among the 6084 patients, aRT did not improve OS across all patients but showed benefits in specific subgroups, such as those with clear cell carcinoma and carcinosarcoma. Nomograms were constructed for patients with/without aRT to predict 1-, 3-, and 5-year OS, and they can accurately forecast OS. Additionally, the web-based calculator was developed to estimate the net OS benefit of aRT.</div></div><div><h3>Conclusions</h3><div>The nomograms provide accurate OS estimates for early-stage type II EC patients with/without aRT, thereby supporting individualized treatment decisions. The web calculator offers a quantitative tool for optimizing aRT use based on clinicopathological characteristics.</div></div>","PeriodicalId":15871,"journal":{"name":"Journal of gynecology obstetrics and human reproduction","volume":"55 3","pages":"Article 103101"},"PeriodicalIF":1.6,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23DOI: 10.1016/j.jogoh.2025.103098
Hengying Chen , Zhehao Wu , Ze Bo , Mingshan Liu
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