Urinary tract infection (UTI) is one of the common causes of hospital visit in infants and children. Vesicoureteral reflux (VUR) predisposes to UTI and renal scarring. VUR is usually diagnosed after an episode of UTI. VUR is the most common underlying etiology responsible for febrile UTIs or pyelonephritis in children. Along with the morbidity of pyelonephritis, long-term sequelae of recurrent renal infections include renal scarring, proteinuria, and hypertension. Treatment is directed toward the prevention of recurrent infection through the use of continuous antibiotic prophylaxis during a period of observation for spontaneous resolution or by surgical correction. In children, bowel and bladder dysfunction (BBD) plays a significant role in the occurrence of UTI and the rate of VUR resolution. Effective treatment of BBD leads to higher rates of spontaneous resolution and decreased risk of UTI.
{"title":"Urinary tract infection and vesicoureteric reflux","authors":"Snehamayee Nayak, N. Sharma, A. Jindal","doi":"10.4103/JINA.JINA_6_17","DOIUrl":"https://doi.org/10.4103/JINA.JINA_6_17","url":null,"abstract":"Urinary tract infection (UTI) is one of the common causes of hospital visit in infants and children. Vesicoureteral reflux (VUR) predisposes to UTI and renal scarring. VUR is usually diagnosed after an episode of UTI. VUR is the most common underlying etiology responsible for febrile UTIs or pyelonephritis in children. Along with the morbidity of pyelonephritis, long-term sequelae of recurrent renal infections include renal scarring, proteinuria, and hypertension. Treatment is directed toward the prevention of recurrent infection through the use of continuous antibiotic prophylaxis during a period of observation for spontaneous resolution or by surgical correction. In children, bowel and bladder dysfunction (BBD) plays a significant role in the occurrence of UTI and the rate of VUR resolution. Effective treatment of BBD leads to higher rates of spontaneous resolution and decreased risk of UTI.","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115140752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of the study was to identify correlation between DNA damage marker 8-hydroxy 2-deoxy guanosine (8-OHdG) and other prognostic factors such as Gleason's score, serum prostate-specific antigen (PSA), and stage in carcinoma prostate and to assess a probability-correlation between DNA damage and benign prostatic hyperplasia (BPH) and control. Materials and Methods: A study has been carried out prospectively. Forty patients of carcinoma prostate, 34 BPH, and 14 healthy controls were included in the study between the period of July 2010 to July 2012. Serum 8-OHdG level was measured in all subjects as a marker of DNA damage. Results: Serum 8-OHdG level was significantly raised in patient with prostate cancer (313.39 ± 69.48 ng/mL) as compared with BPH patients (204.42 ± 40.97 ng/mL) and control group (198.94 ± 15.74 ng/mL) with P< 0.001. Serum 8-OHdG level in BPH patients was higher than the controls, but the mean difference was statistically insignificant (P = 1.000). The patients with serum PSA >20 ng/mL, Gleason's score >6 had higher mean 8-OHdG levels as compared to serum PSA ≤20 and Gleason score ≤6, as P< 0.05. There was also direct association found between prostate volume and stage of the tumor though it was not significant. Conclusions: These findings suggest that oxidative stress level was significantly raised in prostate cancer patients. It was also observed that a significant direct association exists between oxidative stress and certain clinicopathologic factors, including serum PSA, Gleason score, and metastasis which show that with progression of disease, there was increase in oxidative stress level.
{"title":"To find the role of DNA damage marker 8-hydroxy 2-deoxy guanosine in patients of prostate cancer, benign prostatic hyperplasia and its association to other prognostic factors of prostate cancer","authors":"L. Kumar, Sriniwas Kumar, S. Agarwal","doi":"10.4103/JINA.JINA_5_17","DOIUrl":"https://doi.org/10.4103/JINA.JINA_5_17","url":null,"abstract":"Purpose: The aim of the study was to identify correlation between DNA damage marker 8-hydroxy 2-deoxy guanosine (8-OHdG) and other prognostic factors such as Gleason's score, serum prostate-specific antigen (PSA), and stage in carcinoma prostate and to assess a probability-correlation between DNA damage and benign prostatic hyperplasia (BPH) and control. Materials and Methods: A study has been carried out prospectively. Forty patients of carcinoma prostate, 34 BPH, and 14 healthy controls were included in the study between the period of July 2010 to July 2012. Serum 8-OHdG level was measured in all subjects as a marker of DNA damage. Results: Serum 8-OHdG level was significantly raised in patient with prostate cancer (313.39 ± 69.48 ng/mL) as compared with BPH patients (204.42 ± 40.97 ng/mL) and control group (198.94 ± 15.74 ng/mL) with P< 0.001. Serum 8-OHdG level in BPH patients was higher than the controls, but the mean difference was statistically insignificant (P = 1.000). The patients with serum PSA >20 ng/mL, Gleason's score >6 had higher mean 8-OHdG levels as compared to serum PSA ≤20 and Gleason score ≤6, as P< 0.05. There was also direct association found between prostate volume and stage of the tumor though it was not significant. Conclusions: These findings suggest that oxidative stress level was significantly raised in prostate cancer patients. It was also observed that a significant direct association exists between oxidative stress and certain clinicopathologic factors, including serum PSA, Gleason score, and metastasis which show that with progression of disease, there was increase in oxidative stress level.","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123329079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Durrani, M. Pahwa, A. Pahwa, S. Chadha, V. Tyagi, H. Jauhari
Introduction: Success of renal transplantation, besides other factors, depends on the total number of nephrons in the transplanted kidney. The aim of our study was to investigate the effect of ratio of donor kidney weight (DKW) to recipient body weight (RBW) on renal allograft function. Materials and Methods: We conducted a retrospective study at our hospital on 245 patients who underwent live-related kidney transplant. Patients were divided into three groups depending on the ratio of DKW in grams to RBW in kilograms. Results: Mean age of the recipients was 40.19 ± 11.86 years (15–68 years) and donor was 46.18 ± 10.98 years (22–75 years). Male:female ratio for recipients and donors was 205:40 and 163:82, respectively. The decrease in mean creatinine level was more rapid in Group 3 patients as compared with Group 2 and Group 1 patients at 7 days and the trend continued till 3 years. Conclusion: The higher DKW/RBW ratio is an important factor for early function and late function of grafts. Extreme mismatch between the DKW and RBW should be kept in mind, and the DKW/RBW ratio can help us prognosticate patients' renal allograft function.
{"title":"Does graft kidney weight have any impact on renal allograft function?","authors":"A. Durrani, M. Pahwa, A. Pahwa, S. Chadha, V. Tyagi, H. Jauhari","doi":"10.4103/JINA.JINA_40_16","DOIUrl":"https://doi.org/10.4103/JINA.JINA_40_16","url":null,"abstract":"Introduction: Success of renal transplantation, besides other factors, depends on the total number of nephrons in the transplanted kidney. The aim of our study was to investigate the effect of ratio of donor kidney weight (DKW) to recipient body weight (RBW) on renal allograft function. Materials and Methods: We conducted a retrospective study at our hospital on 245 patients who underwent live-related kidney transplant. Patients were divided into three groups depending on the ratio of DKW in grams to RBW in kilograms. Results: Mean age of the recipients was 40.19 ± 11.86 years (15–68 years) and donor was 46.18 ± 10.98 years (22–75 years). Male:female ratio for recipients and donors was 205:40 and 163:82, respectively. The decrease in mean creatinine level was more rapid in Group 3 patients as compared with Group 2 and Group 1 patients at 7 days and the trend continued till 3 years. Conclusion: The higher DKW/RBW ratio is an important factor for early function and late function of grafts. Extreme mismatch between the DKW and RBW should be kept in mind, and the DKW/RBW ratio can help us prognosticate patients' renal allograft function.","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"27 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128247211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-01DOI: 10.4103/2394-2916.208580
M. El-Hamd, S. Aboeldahab
Objectives: The objective of this study was to assess the clinical presentations of perianal warts in boys and to evaluate the possible relationship between the presence of perianal warts and the sexual abuse as mode of transmission. Materials and Methods: In a prospective clinical study, it conducted on 16 boys with clinically evident perianal warts at the Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Upper Egypt, between September 2012 and March 2016. A detailed history from the child and his family was taken. All boys underwent full clinical general and local examinations including (1) site, number, size, and the shape of warts in perianal region, (2) physical signs of sexual abuse, (3) warts in other body areas, and (4) signs of other sexually transmitted diseases. Results: The age of boys ranged from 4 to 10 years, with a mean ± standard deviation of 6.4 ± 1.9 years. Fourteen boys (87.5%) presented with multiple moist papules. Eleven boys (68.75%) had a progressive course. Fourteen boys (87.5%) had no symptoms (incidentally discovered) and 2 boys (12.5%) had perianal itching and pain. Thirteen boys (81.25%) had confirmed history of sexual abuse. Fourteen boys (87.5%) had no physical signs of sexual abuse and 2 boys (12.5%) had perianal fissures. Conclusion: Our results suggested that sexual abuse should be considered in every case of boys with perianal warts.
{"title":"Possible role of sexual abuse in boys with perianal warts","authors":"M. El-Hamd, S. Aboeldahab","doi":"10.4103/2394-2916.208580","DOIUrl":"https://doi.org/10.4103/2394-2916.208580","url":null,"abstract":"Objectives: The objective of this study was to assess the clinical presentations of perianal warts in boys and to evaluate the possible relationship between the presence of perianal warts and the sexual abuse as mode of transmission. Materials and Methods: In a prospective clinical study, it conducted on 16 boys with clinically evident perianal warts at the Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Upper Egypt, between September 2012 and March 2016. A detailed history from the child and his family was taken. All boys underwent full clinical general and local examinations including (1) site, number, size, and the shape of warts in perianal region, (2) physical signs of sexual abuse, (3) warts in other body areas, and (4) signs of other sexually transmitted diseases. Results: The age of boys ranged from 4 to 10 years, with a mean ± standard deviation of 6.4 ± 1.9 years. Fourteen boys (87.5%) presented with multiple moist papules. Eleven boys (68.75%) had a progressive course. Fourteen boys (87.5%) had no symptoms (incidentally discovered) and 2 boys (12.5%) had perianal itching and pain. Thirteen boys (81.25%) had confirmed history of sexual abuse. Fourteen boys (87.5%) had no physical signs of sexual abuse and 2 boys (12.5%) had perianal fissures. Conclusion: Our results suggested that sexual abuse should be considered in every case of boys with perianal warts.","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130939976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-01DOI: 10.4103/2394-2916.208577
Y. Chen, Qin Xue, N. Wang
Atypical hemolytic uremic syndrome (aHUS) is a rare disease of uncontrolled alternative pathway complement activation and pregnancy-associated aHUS (P-aHUS) is a more rare but life-threatening disorder. Besides gene screening, ADAMTS-13 detection and renal biopsy is helpful to establish diagnosis and prognosis assessment when kidney is involved. Combined liver-kidney transplant and eculizumab therapy has generally been the initial approach to this disease management besides therapeutic plasma exchange and plasma infusion. Though transplant and eculizumab therapy may be more effective than traditional therapy, it is much more expensive and not easily available. Herein we report a case of P-aHUS and our case indicates that plasma exchange and hemodialysis may be effective to P-aHUS for those not suitable/available for eculizumab treatment or transplant.
{"title":"Pregnancy-associated atypical hemolytic uremic syndrome: A case report and literature review","authors":"Y. Chen, Qin Xue, N. Wang","doi":"10.4103/2394-2916.208577","DOIUrl":"https://doi.org/10.4103/2394-2916.208577","url":null,"abstract":"Atypical hemolytic uremic syndrome (aHUS) is a rare disease of uncontrolled alternative pathway complement activation and pregnancy-associated aHUS (P-aHUS) is a more rare but life-threatening disorder. Besides gene screening, ADAMTS-13 detection and renal biopsy is helpful to establish diagnosis and prognosis assessment when kidney is involved. Combined liver-kidney transplant and eculizumab therapy has generally been the initial approach to this disease management besides therapeutic plasma exchange and plasma infusion. Though transplant and eculizumab therapy may be more effective than traditional therapy, it is much more expensive and not easily available. Herein we report a case of P-aHUS and our case indicates that plasma exchange and hemodialysis may be effective to P-aHUS for those not suitable/available for eculizumab treatment or transplant.","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129992988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-01DOI: 10.4103/2394-2916.208578
R. Sen, Sumiti Gupta, P. Parmar, Komal Brar, M. Gilotra, Veena Gupta
Myelolipomas are a rare benign variant of adipose tissue tumors with additional hematopoietic elements. In general, these tumors were discovered accidentally on autopsy with a low incidence. Adrenal gland is the most common site for myelolipoma. We reported a case of giant adrenal myelolipoma (>18 cm) which presented with vague, nonspecific pain which is worth mentioning because of its rarity and huge size.
{"title":"Giant adrenal myelolipoma: A rare case report and review of literature","authors":"R. Sen, Sumiti Gupta, P. Parmar, Komal Brar, M. Gilotra, Veena Gupta","doi":"10.4103/2394-2916.208578","DOIUrl":"https://doi.org/10.4103/2394-2916.208578","url":null,"abstract":"Myelolipomas are a rare benign variant of adipose tissue tumors with additional hematopoietic elements. In general, these tumors were discovered accidentally on autopsy with a low incidence. Adrenal gland is the most common site for myelolipoma. We reported a case of giant adrenal myelolipoma (>18 cm) which presented with vague, nonspecific pain which is worth mentioning because of its rarity and huge size.","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"341 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122753556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Primary renal malignant fibrous histiocytoma (MFH) is a rare tumor indistinguishable from renal cell carcinoma clinically and radiologically which can be differentiated only by histological and immunohistochemical studies. We report a case of primary renal MFH in a 40-year-old female who presented with left flank pain. Abdominal ultrasonography and computerized tomography revealed a well-defined renal mass. The contralateral kidney and renal functions were normal. Preoperative diagnosis was renal cell carcinoma and nephrectomy was performed. Histological examination and immunohistochemistry revealed MFH.
{"title":"Malignant fibrous histiocytoma of the kidney","authors":"Sunita Singh, Yashika Bhatia, J. Sharma, R. Sen","doi":"10.4103/JINA.JINA_7_17","DOIUrl":"https://doi.org/10.4103/JINA.JINA_7_17","url":null,"abstract":"Primary renal malignant fibrous histiocytoma (MFH) is a rare tumor indistinguishable from renal cell carcinoma clinically and radiologically which can be differentiated only by histological and immunohistochemical studies. We report a case of primary renal MFH in a 40-year-old female who presented with left flank pain. Abdominal ultrasonography and computerized tomography revealed a well-defined renal mass. The contralateral kidney and renal functions were normal. Preoperative diagnosis was renal cell carcinoma and nephrectomy was performed. Histological examination and immunohistochemistry revealed MFH.","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133495603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Regan E Sevinsky, David W. Stewart, S. Harirforoosh
{"title":"Nonsteroidal anti-inflammatory drugs: Is there a link between cardiovascular and renal adverse effects?","authors":"Regan E Sevinsky, David W. Stewart, S. Harirforoosh","doi":"10.4103/JINA.JINA_2_17","DOIUrl":"https://doi.org/10.4103/JINA.JINA_2_17","url":null,"abstract":"","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114404811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4103/2394-2916.201276
Jiao Liu, JiLei Tang, D. Gong, C. Kong
Objectives: The objective of this study was to explore the values of prostate-specific antigen (PSA) before and after transurethral prostatic resection (TURP) surgery and the corresponding correlation with the resection extent through short and long-term changes of benign prostatic hyperplasia (BPH) of patient's serum PSA after TURP. Materials and Methods: Data were abstracted from a retrospective sampling study of 209 cases of BPH patients. The values of serum PSA level were measured preoperatively and at specified periods after TURP surgery; 5 days, 1 month, 3 months, and 6 months. These periods were correlated with the resection extent. Results: Quantitative PSA values were collected before and after the surgical procedure at the time periods. The decrease of PSA value was observed 5 days after surgery when compared with preoperative PSA value, which is about 4.42 ± 8.78 ng/mL while 35% decrease was reported following a month after surgery. Moreover, PSA levels in these five periods were significantly different (P < 0.01), and the value of PSA >4 ng/mL group is still higher than the group of PSA ≤4 ng/mL after the decrease. Resection extent of TURP: The mean differences between real removal quality and the quality, according to the prostate ultrasonography, should be removed, which is expressed in ± standard deviations. The value of the total sample is −0.941 ± 9.56 ng/mL. Values in the group of PSA ≤4 ng/mL and PSA >4 ng/mL are 0.13 ± 10.53 and −3.83 ± 5.41, respectively. There appears to be a positive correlation between the variations of PSA and the resection extent (P < 0.01, R = 0.91). In addition, a positive correlation was confirmed between the variations of PSA and the resection extent in the group of PSA ≤4 ng/mL and PSA >4 ng/mL (P < 0.01, R 1 = 0.986, R 2 = 0.924). Conclusion: A downward trend is demonstrated here in PSA after TURP. The PSA value lowered to a normal level in about 1 month. The interesting point is that there is an inverse relationship between the larger size of the resection and the decrease in PSA values. Thus, missed and misdiagnoses of prostate cancer could be reduced with the long-term follow-up of BPH patients' postoperative levels of serum after TURP. In regards to patients whose preoperative PSA >4 ng/mL, monitoring standards should be taken according to their postoperative PSA baseline when measuring their results of prostate needle biopsies and the diagnosis of prostatic cancer.
{"title":"Level change of prostate-specific antigen in patients with benign prostatic hyperplasia after transurethral prostatic resection","authors":"Jiao Liu, JiLei Tang, D. Gong, C. Kong","doi":"10.4103/2394-2916.201276","DOIUrl":"https://doi.org/10.4103/2394-2916.201276","url":null,"abstract":"Objectives: The objective of this study was to explore the values of prostate-specific antigen (PSA) before and after transurethral prostatic resection (TURP) surgery and the corresponding correlation with the resection extent through short and long-term changes of benign prostatic hyperplasia (BPH) of patient's serum PSA after TURP. Materials and Methods: Data were abstracted from a retrospective sampling study of 209 cases of BPH patients. The values of serum PSA level were measured preoperatively and at specified periods after TURP surgery; 5 days, 1 month, 3 months, and 6 months. These periods were correlated with the resection extent. Results: Quantitative PSA values were collected before and after the surgical procedure at the time periods. The decrease of PSA value was observed 5 days after surgery when compared with preoperative PSA value, which is about 4.42 ± 8.78 ng/mL while 35% decrease was reported following a month after surgery. Moreover, PSA levels in these five periods were significantly different (P < 0.01), and the value of PSA >4 ng/mL group is still higher than the group of PSA ≤4 ng/mL after the decrease. Resection extent of TURP: The mean differences between real removal quality and the quality, according to the prostate ultrasonography, should be removed, which is expressed in ± standard deviations. The value of the total sample is −0.941 ± 9.56 ng/mL. Values in the group of PSA ≤4 ng/mL and PSA >4 ng/mL are 0.13 ± 10.53 and −3.83 ± 5.41, respectively. There appears to be a positive correlation between the variations of PSA and the resection extent (P < 0.01, R = 0.91). In addition, a positive correlation was confirmed between the variations of PSA and the resection extent in the group of PSA ≤4 ng/mL and PSA >4 ng/mL (P < 0.01, R 1 = 0.986, R 2 = 0.924). Conclusion: A downward trend is demonstrated here in PSA after TURP. The PSA value lowered to a normal level in about 1 month. The interesting point is that there is an inverse relationship between the larger size of the resection and the decrease in PSA values. Thus, missed and misdiagnoses of prostate cancer could be reduced with the long-term follow-up of BPH patients' postoperative levels of serum after TURP. In regards to patients whose preoperative PSA >4 ng/mL, monitoring standards should be taken according to their postoperative PSA baseline when measuring their results of prostate needle biopsies and the diagnosis of prostatic cancer.","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134217064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.4103/2394-2916.201277
T. Balasubramaniyan, J. Dhanapriya, T. Dineshkumar, A. T. Maasila, S. Arivazhagan, D. Rajasekar, R. Sakthirajan, N. Gopalakrishnan
Anti-glomerular basement membrane (anti-GBM) disease is an autoimmune disorder characterized by crescentic glomerulonephritis, pulmonary hemorrhage, and the presence of circulating anti-GBM antibodies which bind to the α3 chain of Type IV collagen found in the GBM. IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. The simultaneous occurrence of atypical anti-GBM disease and IgAN has not been reported previously. We report here two female patients who presented with oliguria, hypertension, and renal failure. Renal biopsy revealed crescentic glomerulonephritis and bright linear IgG staining along glomerular capillary walls and mesangial IgA (3+) deposits in immunofluorescence. Serology was negative for anti-GBM antibodies both by ELISA and immunoblot assays. Hence, a diagnosis of atypical anti-GBM disease with superimposed IgAN was made. Both patients were treated with hemodialysis, intravenous steroids, and cyclophosphamide with the improvement of renal function in one patient and the other progressed to end-stage renal disease.
{"title":"Atypical anti-glomerular basement membrane disease superimposed on IgA nephropathy","authors":"T. Balasubramaniyan, J. Dhanapriya, T. Dineshkumar, A. T. Maasila, S. Arivazhagan, D. Rajasekar, R. Sakthirajan, N. Gopalakrishnan","doi":"10.4103/2394-2916.201277","DOIUrl":"https://doi.org/10.4103/2394-2916.201277","url":null,"abstract":"Anti-glomerular basement membrane (anti-GBM) disease is an autoimmune disorder characterized by crescentic glomerulonephritis, pulmonary hemorrhage, and the presence of circulating anti-GBM antibodies which bind to the α3 chain of Type IV collagen found in the GBM. IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. The simultaneous occurrence of atypical anti-GBM disease and IgAN has not been reported previously. We report here two female patients who presented with oliguria, hypertension, and renal failure. Renal biopsy revealed crescentic glomerulonephritis and bright linear IgG staining along glomerular capillary walls and mesangial IgA (3+) deposits in immunofluorescence. Serology was negative for anti-GBM antibodies both by ELISA and immunoblot assays. Hence, a diagnosis of atypical anti-GBM disease with superimposed IgAN was made. Both patients were treated with hemodialysis, intravenous steroids, and cyclophosphamide with the improvement of renal function in one patient and the other progressed to end-stage renal disease.","PeriodicalId":158840,"journal":{"name":"Journal of Integrative Nephrology and Andrology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115738080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：