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Light amplification by stimulated emission of radiation in fistula-in-ano: innovation or impetuosity? Current position 激光治疗肛瘘:创新还是冲动?流式的位置。
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-13 DOI: 10.1016/j.gassur.2026.102328
Vipul D. Yagnik , Prema Ram Choudhary , Pankaj Garg
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引用次数: 0
Per oral endoscopic myotomy and laparoscopic Heller myotomy show similar outcomes in type III achalasia 经口内窥镜肌切开术和腹腔镜heller肌切开术治疗III型贲门失弛缓症的结果相似。
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-13 DOI: 10.1016/j.gassur.2026.102331
Archana K. Jeeji, Peter T. White, Adam J. Bograd, Alexander S. Farivar, Emily M. Mackay, Brian E. Louie

Background

Achalasia is classified into 3 manometric subtypes with variable treatment response. Guidelines recommend per oral endoscopic myotomy (POEM) over laparoscopic Heller myotomy (LHM) for the treatment of achalasia type III. However, there is limited evidence directly comparing these operations. We aimed to compare the treatment response to POEM vs LHM in type III achalasia.

Methods

We conducted a retrospective, case-control review of patients undergoing primary myotomy for type III achalasia or achalasia variants with type III features. The primary outcome was symptomatic response assessed using the Eckardt score (ES) with a score of ≤3 classified as success. The secondary outcome was the need for reintervention(s) within 3 years.

Results

There were 46 patients, of whom 16 underwent POEM, and 30 underwent LHM. The groups were similar in demographics, preoperative ESs, and rates of preoperative endoscopic interventions. Both groups had median myotomy lengths of 6 cm (4 cm esophageal and 2 cm gastric). After myotomy, both groups had similar rates of success (14/16 POEM vs 26/30 LHM, P =.94). The primary persisting symptom was dysphagia in both groups. Reinterventions occurred in 4/16 (25%) of POEM patients who underwent 9 reinterventions compared with 5/30 (16.7%) LHM patients who underwent 6 reinterventions (P =.49). Most patients in both groups had symptomatic improvement after their last reintervention.

Conclusion

Patients with type III achalasia had similar improvements after undergoing POEM or LHM. There was no difference in reintervention rates between the groups. Patients undergoing reintervention after POEM were more likely to undergo multiple reinterventions.
背景:失弛缓症可分为三种压力测量亚型,治疗反应各不相同。指南推荐口服内窥镜肌切开术(POEM)而不是腹腔镜Heller肌切开术(LHM)治疗III型贲门失弛缓症。然而,直接比较这些操作的证据有限。我们的目的是比较POEM和LHM治疗III型失弛缓症的疗效。方法:我们对因III型失弛缓症或III型失弛缓症变异而接受原发性肌切开术的患者进行了回顾性、病例对照研究。主要结局是使用Eckardt评分(ES)评估症状反应,评分≤3分为成功。次要指标为3年内是否需要再干预。结果:46例患者中16例行POEM, 30例行LHM。两组在人口统计学、术前Eckardt评分和术前内镜干预率方面相似。两组中位切肌长度均为6cm(食管4cm,胃2cm)。在肌切开术后,两组的成功率相似(14/16 POEM vs 26/30 LHM, p=0.94)。两组患者的主要持续症状均为吞咽困难。在接受9次再干预的POEM患者中,有4/16(25%)发生了再干预,而接受6次再干预的LHM患者中有5/30(16.7%)发生了再干预(p=0.49)。两组患者均在最后一次再干预后症状改善。结论:III型贲门失弛缓症患者接受POEM或LHM治疗有相似的改善。两组之间的再干预率没有差异。POEM后再干预的患者更有可能进行多次再干预。
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引用次数: 0
Early Recurrence of Esophagogastric junction adenoCarcinoma after Surgery: a multicentre analysis of risk factors (ERECS Trial) 食管胃交界腺癌术后早期复发:一项多中心危险因素分析(ERECS试验)
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-13 DOI: 10.1016/j.gassur.2026.102329
Stefano de Pascale , Riccardo Rosati , Vincenzo Bagnardi , Andrea Cossu , Giovanni Ferrari , Samuele Frassoni , Simone Giacopuzzi , Monica Gualtierotti , Lucia Moletta , Mario Morino , Giovanni Pallabazzer , Marco Realis Luc , Fabrizio Rebecchi , Stefano Santi , Michele Valmasoni , Jacopo Weindelmayer , Uberto Fumagalli Romario

Background

Esophagogastric junction adenocarcinoma (EGJA) is characterized by a high recurrence rate after esophagectomy, which significantly affects patient survival. This study aimed to identify the risk factors contributing to early recurrence (ER) within 12 months after Ivor Lewis esophagectomy (ILE) in patients with EGJA.

Methods

A retrospective multicenter analysis was conducted across 7 high-volume Italian centers that included 594 patients with Siewert type I and II EGJAs who underwent ILE between January 2018 and December 2022. The clinicopathologic characteristics and postoperative outcomes were analyzed. ER was defined as cancer recurrence within 12 months after surgery. Univariate and multivariate analyses were performed to identify the independent risk factors for ER.

Results

The overall recurrence rate was 41.2% (245/594), with ER occurring in 24.4% (145/594) of patients. The 1-year overall survival rate was 87.7%, and the 1-year recurrence-free survival (RFS) rate was 70.6%. The median RFS was 32.1 months. Multivariate Cox regression analysis identified lower body mass index (hazard ratio [HR], 0.95; P =.009), poor or absent response to neoadjuvant treatment based on the Mandard classification (HR, 2.26; P =.013), and advanced stage (HR, 2.24; P <.001) as independent significant risk factors for ER in EGJA.

Conclusion

Identifying prognostic factors associated with ER allows for the stratification of a subgroup of patients with poor oncological outcomes who require a personalized treatment approach, distinct from the standard multimodal treatment.
背景:食管胃交界腺癌(EGJA)的特点是食管切除术后复发率高,严重影响患者的生存。本研究旨在确定EGJA患者Ivor Lewis食管切除术(ILE)后12个月内早期复发(ER)的危险因素。方法:对意大利7个大容量中心进行回顾性多中心分析,包括2018年1月至2022年12月期间接受ILE治疗的594例siwert I型和II型EGJA患者。分析两组患者的临床病理特征及术后结果。ER定义为术后12个月内肿瘤复发。进行单变量和多变量分析以确定ER的独立危险因素。结果:总复发率为41.2%(245/594),其中ER发生率为24.4%(145/594)。1年总生存率(OS)为87.7%,1年无复发生存率(RFS)为70.6%。中位RFS为32.1个月。多变量Cox回归分析发现,较低的BMI (HR = 0.95, P = 0.009)、基于标准分类的新辅助治疗反应差或无反应(HR = 2.26, P = 0.013)和晚期(HR = 2.24, P < 0.001)是EGJA患者ER的独立显著危险因素。结论:确定与ER相关的预后因素允许对需要个性化治疗方法的患者亚组进行分层,不同于标准的多模式治疗,因为肿瘤预后较差。
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引用次数: 0
A rare type of gastric malignancy: primary gastric Burkitt lymphoma 一种罕见的胃恶性肿瘤:原发性胃伯基特淋巴瘤。
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-12 DOI: 10.1016/j.gassur.2026.102326
Shaoping Xiong, Wenju Chen
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引用次数: 0
Early vs delayed oral feeding after esophagectomy for esophageal cancer: a systematic review and meta-analysis of randomized controlled trials assessing safety, clinical recovery, and quality of life outcomes 食管癌食管切除术后早期与延迟口服喂养:一项评估安全性、临床恢复和生活质量的随机对照试验的系统回顾和荟萃分析
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-12 DOI: 10.1016/j.gassur.2026.102322
Nirmal Paudel , Anurag Jha , Amina Basharat , Muhammad Huzaifa Khalil , Ramsha Ali , Shaista Qadir , Syed Hassan Akhlaq , Muhammad Anas , Muhammad Abbas , Awais Ayub , Muhammad Nabeel Saddique , Nukhbat Ullah Awan

Background

Esophagectomy traditionally involves delayed oral feeding (DOF) due to anastomotic leakage concerns. Enhanced Recovery After Surgery protocols favor early feeding, but its safety remains controversial. This study compared early oral feeding (EOF) and DOF after esophagectomy.

Methods

PubMed, Embase, and Scopus were systematically searched from inception of the study to October 2025 for randomized controlled trials comparing EOF (0–3 days) and DOF (≥5 days) after esophagectomy. The primary outcomes were anastomotic leakage and pneumonia. The secondary outcomes included complications, hospital outcomes, gastrointestinal (GI) recovery, and quality of life (QOL). Effect sizes were calculated as mean differences (MDs) or standardized MDs (SMDs) for continuous variables and risk ratios (RRs) for dichotomous variables, with 95% CIs, using Review Manager (version 5.4; Cochrane Collaboration).

Results

A total of 13 trials involving 1468 patients were included in the study. Early feeding showed no increase in anastomotic leakage (RR, 0.89 [95% CI, 0.55–1.45]; I² = 0%), with consistent safety across anastomotic locations and surgical approaches. Early feeding significantly reduced pneumonia (RR, 0.66 [95% CI, 0.47–0.92]; P =.01) and accelerated GI recovery: time to first bowel movement (MD, −0.50 days [95% CI, −0.55 to −0.46]; P <.00001) and first flatus (MD, −0.61 days [95% CI, −0.95 to −0.26]; P =.0006). Hospital stay was reduced by 1.89 days (95% CI, −3.06 to −0.72; P =.002) with lower medical expenses (SMD, −1.19 [95% CI, −2.07 to −0.30]; P =.009). QOL improved: global health status (MD, 9.08 [95% CI, 3.88–14.29]; P =.0006), dysphagia (MD, −6.15 [95% CI, −9.97 to −2.34]; P =.002), pain (MD, −3.60 [95% CI, −5.32 to −1.89]; P <.00001), and swallowing difficulties (MD, −1.39 [95% CI, −1.53 to −1.26]; P <.00001).

Conclusion

EOF after esophagectomy seems safe and effective, reducing complications while accelerating recovery. However, further high-quality multicenter trials are needed to validate these findings.
背景:传统的食管切除术由于担心吻合口漏而延迟口服喂养。手术后增强恢复(ERAS)方案支持早期喂养,但其安全性仍存在争议。我们比较了食管切除术后早期和延迟口服喂养。方法:我们系统地检索PubMed、Embase和Scopus到2025年10月的随机对照试验,比较食管切除术后早期(50 -3天)和延迟(≥5天)口服喂养。主要结局为吻合口漏和肺炎。次要结局包括并发症、医院结局、胃肠道恢复和生活质量。使用Review Manager5.4计算连续变量的效应量为平均差异(MD)或标准化平均差异(SMD),二分类变量的风险比(RR)为95%置信区间。结果:纳入13项试验,共1468例患者。早期喂养没有增加吻合口漏(RR:0.89, 95% CI:0.55 ~ 1.45, I²=0%),在不同的吻合口位置和手术入路具有一致的安全性。早期喂养可显著减少肺炎(RR:0.66, 95% CI:0.47 ~ 0.92, p=0.01),加速胃肠道恢复:至第一次排便时间(MD:-0.50天,95% CI: -0.55 ~ 0.46)。结论:食管切除术后早期口服喂养安全有效,可减少并发症,加速恢复。然而,需要进一步的高质量多中心试验来验证这些发现。
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引用次数: 0
The association of preoperative nutritional status and physical fitness with postoperative outcomes in esophageal cancer: results from the PReoperative intervention to Improve Outcomes in esophageal cancer patients after Resection study. 食管癌术前营养状况和身体健康与术后预后的关系:来自PRIOR研究的结果
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-12 DOI: 10.1016/j.gassur.2026.102327
Elja A E Reijneveld, Jaap J Dronkers, Iris B Mekenkamp, Joran J Kauw, Ewout A Kouwenhoven, Jan Willem Haveman, Edwin J van Adrichem, Miranda J Velthuis, Sandra Beijer, Jelle P Ruurda, Cindy Veenhof

Purpose: This study aimed to investigate whether preoperative nutritional status and physical fitness after prehabilitation are associated with surgical outcomes, functional capacity, fatigue, and quality of life after esophagectomy.

Methods: This multicenter, observational cohort study included patients with esophageal cancer who underwent curative treatment and multimodal prehabilitation as part of standard care. Preoperative assessments included body mass index (BMI), risk of malnutrition, exercise capacity, handgrip strength (HGS), upper leg muscle function, physical activity level, and fatigue, after finishing prehabilitation. Differences in preoperative parameters between patients with and without postoperative overall or pulmonary complications were analyzed using independent samples t-tests. Associations between preoperative parameters and length of hospital stay, postoperative functional capacity, fatigue, and quality of life were examined using multivariable linear regression models.

Results: A total of 168 patients were included in the study, with a mean age of 65.9 ± 8.6 years and 78.0% of the patients being male. A higher preoperative BMI was associated with more overall complications (P =.029). Better preoperative exercise capacity and upper leg muscle function were associated with less pulmonary complications (P <.045) and better postoperative functional capacity (P <.032). Less preoperative fatigue was associated with better postoperative functional capacity, quality of life, and less fatigue (P ≤.001). Risk of malnutrition, HGS, and physical activity level were not significantly associated with postoperative outcomes.

Conclusion: BMI, exercise capacity, upper leg muscle function, and fatigue seem to be important factors in the preoperative assessment before esophagectomy in terms of postoperative complications, postoperative functional capacity, fatigue, and quality of life. During prehabilitation, specific attention is needed for patients with a high BMI, low fitness level, and high fatigue.

目的:探讨食管癌患者术前营养状况和康复后的身体健康状况是否与食管癌术后预后、功能能力、疲劳和生活质量相关。方法:这项多中心、观察性队列研究纳入了接受根治性治疗和作为标准治疗一部分的多模式康复治疗的食管癌患者。术前评估包括身体质量指数(BMI)、营养不良风险、运动能力、握力、上肢肌肉功能、体力活动水平和完成康复后的疲劳程度。采用独立t检验分析有和无术后整体或肺部并发症患者术前参数的差异。使用多变量线性回归模型检查与住院时间、术后功能能力、疲劳和生活质量的关系。结果:纳入患者168例,平均年龄65.9±8.6岁;78.0%的男性。术前BMI越高,总并发症越多(p= 0.029)。结论:BMI、运动能力、上肢肌肉功能和疲劳似乎是食管切除术前术前评估的重要因素,无论是在术后并发症、术后功能能力、疲劳和生活质量方面。因此,在(p)康复过程中,需要特别注意高BMI、低健康水平和高疲劳的患者。
{"title":"The association of preoperative nutritional status and physical fitness with postoperative outcomes in esophageal cancer: results from the PReoperative intervention to Improve Outcomes in esophageal cancer patients after Resection study.","authors":"Elja A E Reijneveld, Jaap J Dronkers, Iris B Mekenkamp, Joran J Kauw, Ewout A Kouwenhoven, Jan Willem Haveman, Edwin J van Adrichem, Miranda J Velthuis, Sandra Beijer, Jelle P Ruurda, Cindy Veenhof","doi":"10.1016/j.gassur.2026.102327","DOIUrl":"10.1016/j.gassur.2026.102327","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate whether preoperative nutritional status and physical fitness after prehabilitation are associated with surgical outcomes, functional capacity, fatigue, and quality of life after esophagectomy.</p><p><strong>Methods: </strong>This multicenter, observational cohort study included patients with esophageal cancer who underwent curative treatment and multimodal prehabilitation as part of standard care. Preoperative assessments included body mass index (BMI), risk of malnutrition, exercise capacity, handgrip strength (HGS), upper leg muscle function, physical activity level, and fatigue, after finishing prehabilitation. Differences in preoperative parameters between patients with and without postoperative overall or pulmonary complications were analyzed using independent samples t-tests. Associations between preoperative parameters and length of hospital stay, postoperative functional capacity, fatigue, and quality of life were examined using multivariable linear regression models.</p><p><strong>Results: </strong>A total of 168 patients were included in the study, with a mean age of 65.9 ± 8.6 years and 78.0% of the patients being male. A higher preoperative BMI was associated with more overall complications (P =.029). Better preoperative exercise capacity and upper leg muscle function were associated with less pulmonary complications (P <.045) and better postoperative functional capacity (P <.032). Less preoperative fatigue was associated with better postoperative functional capacity, quality of life, and less fatigue (P ≤.001). Risk of malnutrition, HGS, and physical activity level were not significantly associated with postoperative outcomes.</p><p><strong>Conclusion: </strong>BMI, exercise capacity, upper leg muscle function, and fatigue seem to be important factors in the preoperative assessment before esophagectomy in terms of postoperative complications, postoperative functional capacity, fatigue, and quality of life. During prehabilitation, specific attention is needed for patients with a high BMI, low fitness level, and high fatigue.</p>","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":" ","pages":"102327"},"PeriodicalIF":2.4,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invited commentary on “Restoring bowel continuity after extended left colectomy: a comparative study of the retroileal window and Deloyers techniques” 特邀评论“延长左结肠切除术后恢复肠道连续性:回肠后窗和Deloyers技术的比较研究”
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.gassur.2025.102309
Vitaliy Poylin
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引用次数: 0
Overuse of subtotal cholecystectomy: surgeon practice patterns and outcomes in a large healthcare system 过度使用胆囊次全切除术:大型医疗保健系统的外科医生实践模式和结果。
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-08 DOI: 10.1016/j.gassur.2026.102325
Ramsey Michael Dallal , Samantha Ekanayake , Alec C. Beekley , Sultan Mahmoud Abdelhamid , Radi F. Zaki , Noah Streitfeld , Charles J. Yeo

Background

Subtotal cholecystectomy (SC) is a possible bailout procedure to prevent bile duct injuries (BDIs) when a critical view of safety cannot be obtained during cholecystectomy (CC).

Methods

This retrospective study analyzed 17,299 CCs performed by 111 surgeons across 12 hospitals within 1 large healthcare system using multilevel propensity-weighted logistic regression to model the risk of SC and reinterventions, accounting for patient-, surgeon-, and hospital-level factors.

Results

Among 157 SC cases, 94 (60%) were performed by just 8 surgeons, who collectively accounted for only 13% of all CCs. In addition, 136 cases (87%) of SC were concentrated in 3 hospitals, accounting for 31% of all CCs. Surgeons with increasing experience performing SC were significantly more likely to perform the procedure (odds ratio [OR], 1.13; P =.004). Conversely, the more CCs a surgeon performed, the lower the likelihood of performing an SC (OR, 0.998; P <.001). Fellowship training and years of experience were not significant independent predictors. The 30-day disease-specific reintervention rate after SC was 22.3%. There was no detectable increase in reinterventions among surgeons or hospitals who had never or rarely performed SC. In addition, 6 major BDIs requiring reconstruction were identified after CC (BDI rate of 0.03%). Surgeon-level variability, not hospital-level variability, explained the residual clustering of SC use, accounting for 16% of the adjusted residual.

Conclusion

SC use was primarily surgeon driven, even after accounting for patient factors that were independently associated with SC. These findings challenge SC’s role as a universal bailout and call for curbing its discretionary overuse.
背景:当在胆囊切除术(CC)中不能获得安全的关键观点时,胆囊次全切除术(SC)是一种可能预防胆管损伤(BDI)的救助手术。方法:我们回顾性分析了一个大型医疗保健系统内12家医院111名外科医生进行的17,299例(cc)手术,采用多层次倾向加权logistic回归模型,考虑患者、外科医生和医院层面的因素,对SC和再干预的风险进行建模。结果:157例SC病例中,60%由8名外科医生完成,合计仅占全部胆囊切除术的13%。136例(87%)SC集中在3家医院,占所有CC的31%。经验丰富的外科医生更有可能实施SC手术(OR 1.13, p = 0.004)。相反,外科医生行CC越多,行SC的可能性越低(OR 0.998, p < 0.001)。研究金培训和经验年数不是显著的独立预测因子。SC后30天疾病特异性再干预率为22.3%。在从未或很少行过SC的外科医生或医院中,再干预的发生率没有明显增加。CC后发现了6个需要重建的主要胆管损伤(BDI率为0.03%)。外科医生水平的可变性,而不是医院水平的可变性,解释了SC使用的残差聚类,占调整残差的16%。结论:SC的使用主要是由外科医生驱动的,即使在考虑了与SC独立相关的患者因素之后。这些发现挑战了SC作为普遍救助的作用,并呼吁限制其酌情过度使用。
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引用次数: 0
Invited commentary on “Contemporary emergency management and 1-year outcomes of colonic diverticulitis: a population-based cohort study” 特邀评论:当代急诊管理和结肠憩室炎的1年预后:一项基于人群的队列研究。
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-07 DOI: 10.1016/j.gassur.2026.102323
Sean J. Langenfeld
{"title":"Invited commentary on “Contemporary emergency management and 1-year outcomes of colonic diverticulitis: a population-based cohort study”","authors":"Sean J. Langenfeld","doi":"10.1016/j.gassur.2026.102323","DOIUrl":"10.1016/j.gassur.2026.102323","url":null,"abstract":"","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"30 3","pages":"Article 102323"},"PeriodicalIF":2.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145944556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic-assisted decompression of the celiac trunk via the common hepatic artery approach for median arcuate ligament syndrome 经肝总动脉入路腹腔干机器人辅助减压治疗正中弓状韧带综合征。
IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2026-01-06 DOI: 10.1016/j.gassur.2026.102321
Michela Orsi, Lorenza Beomonte Zobel, Giuseppe S. Sica
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引用次数: 0
期刊
Journal of Gastrointestinal Surgery
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