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Portal hypertension or histologic characteristics of the liver? 致编辑的信,内容涉及 "切除范围和潜在肝病影响 ACS NSQIP 风险计算器术前风险评估的准确性 "一文:"切除范围和潜在肝病影响 ACS NSQIP 风险计算器术前风险评估的准确性"。
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.gassur.2024.101881
Lidia Canillas , Amalia Pelegrina , Juan Álvarez , José A. Carrión
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引用次数: 0
Tips for creating the ideal gastric conduit 创建理想胃导管的技巧。
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.gassur.2024.101927
Carolina Garcia, Ziad T. Awad
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引用次数: 0
The impact of fellowship training on current practice patterns and the job market: a survey of Fellowship Council graduates 研究金培训对当前实践模式和就业市场的影响:对研究金理事会毕业生的调查。
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.gassur.2024.101893
Michael Jureller , D. Rohan Jeyarajah , Imran Hassan , Maria S. Altieri , On behalf of the Society for Surgery of the Alimentary Tract Complex Gastrointestinal Fellowship Committee

Background

General surgery has changed significantly over the last decades, with the need for advanced training and expertise. The Fellowship Council (FC) accredits fellowships that train approximately 200 fellows annually. This study aimed to analyze FC graduates’ perceptions of training, current practices, and the job market.

Methods

Data were collected between May 2022 and June 2022 via a survey (SurveyMonkey; Momentive Inc) distributed via email to 2119 previous FC graduates from 2012 to 2021.

Results

There were 257 respondents. However, less than half of the respondents (47%) came from surgeons within the first 3 years after training. Of the respondents, 38% had advanced gastrointestinal (GI) minimally invasive surgery (MIS) training, 26% had bariatric surgery training, 14% had foregut surgery training, and the remaining 22% had hepatobiliary, advanced/complex GI, advanced endoscopy, and colorectal surgery training. Most respondents performed acute care surgery (ACS) as part of their training. Of note, 75% of respondents take ACS call, and 55% of respondents do not perform some operations that they trained in during their fellowship. More than 60% of surgeons had difficulty securing employment.

Conclusion

Despite niche training, there exists a demand for ACS care. There may be an underutilization of advanced training, or this may reflect how surgeons enter practice and gain experience. The challenge in obtaining employment may be due to the saturation of the market, selectivity of the applicants, or hiring challenges during the COVID-19 pandemic. Most surgeons who undertook FC training practice surgery within their domains of training and with some components of ACS. Despite the desire to hire fellowship-trained surgeons, most FC graduates experience difficulty securing employment.
背景:在过去的几十年里,普通外科发生了显著的变化,需要先进的培训和专业知识。奖学金理事会(FC)每年认可约200名奖学金获得者。本研究旨在分析金融学院毕业生对培训、现行做法和就业市场的看法。方法:于2022年5月至2022年6月通过调查(SurveyMonkey;在2012年至2021年期间,通过电子邮件向2119名FC毕业生分发。结果:调查对象257人。然而,不到一半的受访者(47%)来自培训后的前3年内的外科医生。在受访者中,38%接受过高级胃肠道(GI)微创手术(MIS)培训,26%接受过减肥手术培训,14%接受过前肠手术培训,其余22%接受过肝胆、高级/复杂胃肠道、高级内窥镜检查和结直肠手术培训。大多数受访者进行急症护理手术(ACS)作为他们培训的一部分。值得注意的是,75%的受访者接听ACS电话,55%的受访者不执行他们在奖学金期间接受过培训的一些操作。超过60%的外科医生很难找到工作。结论:尽管有针对性的培训,但仍存在ACS护理需求。高级培训的利用可能不足,或者这可能反映了外科医生如何进入实践并获得经验。就业方面的挑战可能是由于市场饱和、申请人的选择性或COVID-19大流行期间的招聘挑战。大多数接受FC培训的外科医生在他们的培训领域和ACS的一些组成部分进行手术实践。尽管希望聘用接受过奖学金培训的外科医生,但大多数FC毕业生都很难找到工作。
{"title":"The impact of fellowship training on current practice patterns and the job market: a survey of Fellowship Council graduates","authors":"Michael Jureller ,&nbsp;D. Rohan Jeyarajah ,&nbsp;Imran Hassan ,&nbsp;Maria S. Altieri ,&nbsp;On behalf of the Society for Surgery of the Alimentary Tract Complex Gastrointestinal Fellowship Committee","doi":"10.1016/j.gassur.2024.101893","DOIUrl":"10.1016/j.gassur.2024.101893","url":null,"abstract":"<div><h3>Background</h3><div>General surgery has changed significantly over the last decades, with the need for advanced training and expertise. The Fellowship Council (FC) accredits fellowships that train approximately 200 fellows annually. This study aimed to analyze FC graduates’ perceptions of training, current practices, and the job market.</div></div><div><h3>Methods</h3><div>Data were collected between May 2022 and June 2022 via a survey (SurveyMonkey; Momentive Inc) distributed via email to 2119 previous FC graduates from 2012 to 2021.</div></div><div><h3>Results</h3><div>There were 257 respondents. However, less than half of the respondents (47%) came from surgeons within the first 3 years after training. Of the respondents, 38% had advanced gastrointestinal (GI) minimally invasive surgery (MIS) training, 26% had bariatric surgery training, 14% had foregut surgery training, and the remaining 22% had hepatobiliary, advanced/complex GI, advanced endoscopy, and colorectal surgery training. Most respondents performed acute care surgery (ACS) as part of their training. Of note, 75% of respondents take ACS call, and 55% of respondents do not perform some operations that they trained in during their fellowship. More than 60% of surgeons had difficulty securing employment.</div></div><div><h3>Conclusion</h3><div>Despite niche training, there exists a demand for ACS care. There may be an underutilization of advanced training, or this may reflect how surgeons enter practice and gain experience. The challenge in obtaining employment may be due to the saturation of the market, selectivity of the applicants, or hiring challenges during the COVID-19 pandemic. Most surgeons who undertook FC training practice surgery within their domains of training and with some components of ACS. Despite the desire to hire fellowship-trained surgeons, most FC graduates experience difficulty securing employment.</div></div>","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101893"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Review and Meta-Analysis of Factors Associated with Esophageal Stent Migration and a Comparison of Anti-Migration Techniques.
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-30 DOI: 10.1016/j.gassur.2025.101977
Olivia Heutlinger, Nischal Acharya, Sohrab Kharabaf, Nisha Acharya, Samantha Perez-Menendez, Kate Kirby, Brian Smith, Ninh T Nguyen

Background: Esophageal stents are efficacious in managing many different pathologies. However, they are limited by their common complication of migration. We present the largest comprehensive review of the risk factors associated with stent migration and interventions leveraged to prevent it.

Methods: A systematic review was conducted following PRISMA guidelines. Inclusion criteria were primary data sources (no systematic reviews), ≥18 years of age, esophageal stent placement, and reported indication for intervention, site of placement, and migration rate. 162 papers met this criterion. Proportions experiencing migration were pooled using a random effects model with a DerSimonian-Laird estimator to account for potential heterogeneity and forest plots were used to visualize the treatment effects across studies.

Results: There were 14,092 patients included in the analysis. The mean migration rate across all studies and stent types was 17.2% and the mean reintervention rate was 83.2%. Cancerous indications, benign strictures, history of esophageal surgery, stent diameter <20mm, plastic stents, and fully covered stents were associated with significantly higher migration rates. There was a trend towards stents using anti-migration technology having lower migration rates (effect size (ES)=0.15, 95% confidence interval (CI) 0.10-0.20) compared to those that did not (ES=0.33, 95% CI 0.18-0.48), however this difference was not significant. There were no statistically significant differences between stent fixation strategies (clips, sutures, wire hooks, Shim's technique).

Conclusion: There are several risk factors associated with stent migration; however no current solutions confer significantly reduced stent migration. Further optimization of these devices or creation of new technology to prevent migration is indicated.

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引用次数: 0
Anatomical insights into Rouviere’s Sulcus through the Glissonean approach in minimally invasive right-sided sepatectomy
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-29 DOI: 10.1016/j.gassur.2025.101981
Sung Chun Cho , Ji Hoon Kim

Background

Understanding the liver anatomy, particularly the Rouviere sulcus (RS), is crucial for safely performing cholecystectomy and hepatectomy. As surgical interest in right-sided hepatectomies using the Glissonean pedicle approach has increased, a thorough understanding of the RS anatomy is becoming increasingly important. This study aimed to investigate the presence and anatomical contents of the RS during right-sided hepatectomy and to develop a preoperative assessment method to improve surgical safety and precision.

Methods

Patients who underwent laparoscopic or robotic right-sided hepatectomy with RS dissection were included in the study. The RS was categorized into open and closed types, and its contents were examined to identify the presence of Glissonean pedicles. The findings were compared with simulations generated from 3-dimensional reconstruction imaging for further analysis.

Results

Of the 83 patients, 62 (74.7%) had open-type RS, and 21 (25.3%) had closed-type RS. Among the open-type RS cases, 38 patients (61.3%) involved the right posterior Glissonean pedicle within the RS, whereas 19 patients (30.7%) involved segment 6 Glissonean pedicle. Preoperative imaging revealed that when the right posterior Glissonean pedicle did not form a common trunk with segments 6 and 7, the Glissonean pedicle of segment 6 was located within the RS. The variation observed in 5 cases (8.1%) with the right main Glissonean pedicle in the RS was significant and should be carefully considered during surgery.

Conclusion

A thorough understanding of the RS anatomy is essential for safe and precise right-sided hepatectomy. Our findings emphasize the variability of RS, particularly concerning the presence of different Glissonean pedicles, including the right posterior segment 6 and, in rare cases, the right main Glissonean pedicle. Our findings highlight the necessity for individualized preoperative imaging and careful consideration of anatomical variations to minimize complications during right-sided hepatectomy.
{"title":"Anatomical insights into Rouviere’s Sulcus through the Glissonean approach in minimally invasive right-sided sepatectomy","authors":"Sung Chun Cho ,&nbsp;Ji Hoon Kim","doi":"10.1016/j.gassur.2025.101981","DOIUrl":"10.1016/j.gassur.2025.101981","url":null,"abstract":"<div><h3>Background</h3><div>Understanding the liver anatomy, particularly the Rouviere sulcus (RS), is crucial for safely performing cholecystectomy and hepatectomy. As surgical interest in right-sided hepatectomies using the Glissonean pedicle approach has increased, a thorough understanding of the RS anatomy is becoming increasingly important. This study aimed to investigate the presence and anatomical contents of the RS during right-sided hepatectomy and to develop a preoperative assessment method to improve surgical safety and precision.</div></div><div><h3>Methods</h3><div>Patients who underwent laparoscopic or robotic right-sided hepatectomy with RS dissection were included in the study. The RS was categorized into open and closed types, and its contents were examined to identify the presence of Glissonean pedicles. The findings were compared with simulations generated from 3-dimensional reconstruction imaging for further analysis.</div></div><div><h3>Results</h3><div>Of the 83 patients, 62 (74.7%) had open-type RS, and 21 (25.3%) had closed-type RS. Among the open-type RS cases, 38 patients (61.3%) involved the right posterior Glissonean pedicle within the RS, whereas 19 patients (30.7%) involved segment 6 Glissonean pedicle. Preoperative imaging revealed that when the right posterior Glissonean pedicle did not form a common trunk with segments 6 and 7, the Glissonean pedicle of segment 6 was located within the RS. The variation observed in 5 cases (8.1%) with the right main Glissonean pedicle in the RS was significant and should be carefully considered during surgery.</div></div><div><h3>Conclusion</h3><div>A thorough understanding of the RS anatomy is essential for safe and precise right-sided hepatectomy. Our findings emphasize the variability of RS, particularly concerning the presence of different Glissonean pedicles, including the right posterior segment 6 and, in rare cases, the right main Glissonean pedicle. Our findings highlight the necessity for individualized preoperative imaging and careful consideration of anatomical variations to minimize complications during right-sided hepatectomy.</div></div>","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 4","pages":"Article 101981"},"PeriodicalIF":2.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invited commentary: human effluvia, microbiome-based biomarkers and cancer screening
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-29 DOI: 10.1016/j.gassur.2025.101976
John C. Alverdy
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引用次数: 0
Achieving textbook outcomes with robotic-assisted Ivor Lewis esophagectomy: a single-center experience with 150 consecutive patients
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-29 DOI: 10.1016/j.gassur.2025.101979
Moshim Kukar , Faisal Jehan , Maureen Brady , Kristopher Attwood , Steven N. Hochwald

Background

With published randomized data, minimally invasive esophagectomy (MIE) has become increasingly popular. However, substantial variability in techniques and outcomes still exists.

Methods

This was a retrospective analysis of 150 consecutive robotic-assisted MIEs (RAMIEs) from a prospectively maintained database from 2020 to 2024 at a single comprehensive cancer center. This study aimed to evaluate the textbook outcome rates after RAMIE.

Results

A total of 150 consecutive patients underwent RAMIE from 2020 to 2024. Tumor location included the esophagus in 18 patients, type 1 gastroesophageal junction (GEJ) in 52 patients, type 2 GEJ in 71 patients, and type 3 GEJ in 9 patients. Most patients had clinical stage T3 tumors. Neoadjuvant therapy was used in 85% of the patients. A complete pathologic response was observed in 27% of patients. The median number of lymph nodes retrieved was 21. Anastomotic leak occurred in 2 patients, none of whom required reoperation. The median hospital stay duration was 7 days. The 30- and 90-day mortality rates were 0.7% and 1.3%, respectively. In addition, the 90-day stricture rate after endoscopic dilation was 0.7%. Of note, 90% of patients had a textbook outcome.

Conclusion

This single-center experience highlights that the combination of a robotic platform and a side-to-side stapled anastomotic technique helps achieve exceptional postoperative outcomes for MIE, with a textbook outcome rate of 90%. With the increasing worldwide adoption of MIE, this seems to be an appropriate time to standardize operative techniques to optimize postoperative outcomes.
{"title":"Achieving textbook outcomes with robotic-assisted Ivor Lewis esophagectomy: a single-center experience with 150 consecutive patients","authors":"Moshim Kukar ,&nbsp;Faisal Jehan ,&nbsp;Maureen Brady ,&nbsp;Kristopher Attwood ,&nbsp;Steven N. Hochwald","doi":"10.1016/j.gassur.2025.101979","DOIUrl":"10.1016/j.gassur.2025.101979","url":null,"abstract":"<div><h3>Background</h3><div>With published randomized data, minimally invasive esophagectomy (MIE) has become increasingly popular. However, substantial variability in techniques and outcomes still exists.</div></div><div><h3>Methods</h3><div>This was a retrospective analysis of 150 consecutive robotic-assisted MIEs (RAMIEs) from a prospectively maintained database from 2020 to 2024 at a single comprehensive cancer center. This study aimed to evaluate the textbook outcome rates after RAMIE.</div></div><div><h3>Results</h3><div>A total of 150 consecutive patients underwent RAMIE from 2020 to 2024. Tumor location included the esophagus in 18 patients, type 1 gastroesophageal junction (GEJ) in 52 patients, type 2 GEJ in 71 patients, and type 3 GEJ in 9 patients. Most patients had clinical stage T3 tumors. Neoadjuvant therapy was used in 85% of the patients. A complete pathologic response was observed in 27% of patients. The median number of lymph nodes retrieved was 21. Anastomotic leak occurred in 2 patients, none of whom required reoperation. The median hospital stay duration was 7 days. The 30- and 90-day mortality rates were 0.7% and 1.3%, respectively. In addition, the 90-day stricture rate after endoscopic dilation was 0.7%. Of note, 90% of patients had a textbook outcome.</div></div><div><h3>Conclusion</h3><div>This single-center experience highlights that the combination of a robotic platform and a side-to-side stapled anastomotic technique helps achieve exceptional postoperative outcomes for MIE, with a textbook outcome rate of 90%. With the increasing worldwide adoption of MIE, this seems to be an appropriate time to standardize operative techniques to optimize postoperative outcomes.</div></div>","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 4","pages":"Article 101979"},"PeriodicalIF":2.2,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical features of abdominal immunoglobulin A vasculitis in adults: a single-center retrospective study
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-28 DOI: 10.1016/j.gassur.2025.101975
Zi-Ping Cai , Hong-Yang Wu , Shun Xu , Wei Liu
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引用次数: 0
Cluster analysis of hepatocellular carcinoma prognosis using preoperative alpha-fetoprotein and des-gamma-carboxy prothrombin levels: a multi-institutional study
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-28 DOI: 10.1016/j.gassur.2025.101980
Yoshitaka Saegusa , Yuki Imaoka , Masahiro Ohira , Tsuyoshi Kobayashi , Naruhiko Honmyo , Michinori Hamaoka , Takashi Onoe , Daisuke Takei , Koichi Oishi , Tomoyuki Abe , Toshihiro Nakayama , Miho Akabane , Kazunari Sasaki , Hideki Ohdan , Hiroshima Surgical Study Group of Clinical Oncology

Background

Hepatocellular carcinoma (HCC) remains the leading cause of cancer-related mortality worldwide and is characterized by high recurrence rates after curative resection. The tumor markers des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) are crucial for HCC diagnosis and prognosis. However, their roles in the modern era of HCC epidemiology require reevaluation.

Methods

This multi-institutional retrospective study analyzed 1515 patients who underwent hepatectomy for primary HCC. Patients were classified into 4 clusters using k-means analysis based on preoperative DCP and AFP levels. Clinicopathologic characteristics, overall survival (OS), and recurrence rate (RR) were evaluated using Cox proportional hazards models and area under the receiver operating characteristic curve (AUROC) comparisons.

Results

Cluster 3 (concurrent elevations of DCP and AFP) had the poorest 5-year OS (52.8%) and the highest RR (79.3%), whereas cluster 4 (low levels of both markers) had the most favorable outcomes, with a 5-year OS rate of 71.5% and an RR of 55.7%. Cluster 1 (elevated DCP alone) was associated with larger tumors (median of 45 mm) and more frequent vascular invasion (43%) than cluster 2 (elevated AFP alone, median tumor size of 24 mm, and vascular invasion of 36%). DCP was a stronger predictor of 5-year OS in patients with preserved liver function (AUROC, 0.63), whereas AFP was more effective in stratifying RR in patients with impaired liver function (AUROC, 0.57). Non-B, non-C hepatitis (NBNC)-related HCC exhibited a distinct biomarker profile, with an elevated DCP level correlating with a higher 5-year RR (67%) than other etiologies.

Conclusion

Our study introduces tumor marker clustering as a novel analytical approach, providing a nuanced understanding of AFP and DCP’s combined utility in predicting prognosis and recurrence. Our findings highlight the independent and complementary roles of these biomarkers, particularly in NBNC-related HCC and in cases with impaired liver function. AFP and DCP remain crucial tools for recurrence risk assessment, guiding personalized management strategies, such as surveillance, neoadjuvant therapies, and tailored postoperative interventions.
{"title":"Cluster analysis of hepatocellular carcinoma prognosis using preoperative alpha-fetoprotein and des-gamma-carboxy prothrombin levels: a multi-institutional study","authors":"Yoshitaka Saegusa ,&nbsp;Yuki Imaoka ,&nbsp;Masahiro Ohira ,&nbsp;Tsuyoshi Kobayashi ,&nbsp;Naruhiko Honmyo ,&nbsp;Michinori Hamaoka ,&nbsp;Takashi Onoe ,&nbsp;Daisuke Takei ,&nbsp;Koichi Oishi ,&nbsp;Tomoyuki Abe ,&nbsp;Toshihiro Nakayama ,&nbsp;Miho Akabane ,&nbsp;Kazunari Sasaki ,&nbsp;Hideki Ohdan ,&nbsp;Hiroshima Surgical Study Group of Clinical Oncology","doi":"10.1016/j.gassur.2025.101980","DOIUrl":"10.1016/j.gassur.2025.101980","url":null,"abstract":"<div><h3>Background</h3><div>Hepatocellular carcinoma (HCC) remains the leading cause of cancer-related mortality worldwide and is characterized by high recurrence rates after curative resection. The tumor markers des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) are crucial for HCC diagnosis and prognosis. However, their roles in the modern era of HCC epidemiology require reevaluation.</div></div><div><h3>Methods</h3><div>This multi-institutional retrospective study analyzed 1515 patients who underwent hepatectomy for primary HCC. Patients were classified into 4 clusters using k-means analysis based on preoperative DCP and AFP levels. Clinicopathologic characteristics, overall survival (OS), and recurrence rate (RR) were evaluated using Cox proportional hazards models and area under the receiver operating characteristic curve (AUROC) comparisons.</div></div><div><h3>Results</h3><div>Cluster 3 (concurrent elevations of DCP and AFP) had the poorest 5-year OS (52.8%) and the highest RR (79.3%), whereas cluster 4 (low levels of both markers) had the most favorable outcomes, with a 5-year OS rate of 71.5% and an RR of 55.7%. Cluster 1 (elevated DCP alone) was associated with larger tumors (median of 45 mm) and more frequent vascular invasion (43%) than cluster 2 (elevated AFP alone, median tumor size of 24 mm, and vascular invasion of 36%). DCP was a stronger predictor of 5-year OS in patients with preserved liver function (AUROC, 0.63), whereas AFP was more effective in stratifying RR in patients with impaired liver function (AUROC, 0.57). Non-B, non-C hepatitis (NBNC)-related HCC exhibited a distinct biomarker profile, with an elevated DCP level correlating with a higher 5-year RR (67%) than other etiologies.</div></div><div><h3>Conclusion</h3><div>Our study introduces tumor marker clustering as a novel analytical approach, providing a nuanced understanding of AFP and DCP’s combined utility in predicting prognosis and recurrence. Our findings highlight the independent and complementary roles of these biomarkers, particularly in NBNC-related HCC and in cases with impaired liver function. AFP and DCP remain crucial tools for recurrence risk assessment, guiding personalized management strategies, such as surveillance, neoadjuvant therapies, and tailored postoperative interventions.</div></div>","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 4","pages":"Article 101980"},"PeriodicalIF":2.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cystic echinococcosis of the liver 肝囊性棘球蚴病
IF 2.2 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-27 DOI: 10.1016/j.gassur.2025.101974
Hassan Aziz , Peyton Seda , Yashant Aswani , Matthew D. Gosse , Aparna Joshi Krishnakumari , Timothy M. Pawlik

Background

Cystic echinococcosis (CE) is a widely endemic helminthic disease caused by infection with metacestodes (larval stage) of the Echinococcus granulosus tapeworm, which is transmitted by dogs and found on every continent, except Antarctica. This study aimed to review the life cycle, epidemiology, symptoms, diagnostic methods, and treatment of E granulosus infection of the liver.

Methods

A comprehensive review was conducted using MEDLINE/PubMed, Google Scholar, Cochrane Library, and the Web of Science, which were accessed between 1990 and 2024. The main search focused on “CE of the liver.” The following terms were used: cystic echinococcosis, hydatidosis, E granulosus, echinococcus life cycle, liver cyst, albendazole, liver resection, pericystectomy, cystobiliary fistula, and percutaneous aspiration injection and reaspiration (PAIR).

Results

CE should be considered in the differential diagnosis of hepatic cysts, especially among individuals with risk factors, such as those who have traveled to or immigrated from areas with a high prevalence. Echinococcus species require 2 hosts to complete their life cycle, with humans acting as intermediate hosts that become infected by ingesting eggs from contaminated environments, leading to cyst formation, typically in the liver or lungs. Symptoms are based on cyst size and location, such as abdominal pain, jaundice, respiratory distress, or neurologic deficits, and can lead to severe complications, such as cyst rupture, allergic reactions, sepsis, or secondary hydatidosis. Imaging plays a key role in evaluating cyst stage, size, location, and potential complications and in determining the appropriateness of a minimally invasive PAIR procedure. Although serum antibody tests typically have a low sensitivity, antigen assays or recombinant proteins may provide useful diagnostic information. For uncomplicated active cysts, the treatment options include chemotherapy alone or in combination with the PAIR technique.

Conclusion

Hepatic echinococcal cysts, which are relatively rare in North America, should be considered in the differential diagnosis of hepatic cysts, especially in individuals with risk factors.
{"title":"Cystic echinococcosis of the liver","authors":"Hassan Aziz ,&nbsp;Peyton Seda ,&nbsp;Yashant Aswani ,&nbsp;Matthew D. Gosse ,&nbsp;Aparna Joshi Krishnakumari ,&nbsp;Timothy M. Pawlik","doi":"10.1016/j.gassur.2025.101974","DOIUrl":"10.1016/j.gassur.2025.101974","url":null,"abstract":"<div><h3>Background</h3><div>Cystic echinococcosis (CE) is a widely endemic helminthic disease caused by infection with metacestodes (larval stage) of the <em>Echinococcus granulosus</em> tapeworm, which is transmitted by dogs and found on every continent, except Antarctica. This study aimed to review the life cycle, epidemiology, symptoms, diagnostic methods, and treatment of <em>E granulosus</em> infection of the liver.</div></div><div><h3>Methods</h3><div>A comprehensive review was conducted using MEDLINE/PubMed, Google Scholar, Cochrane Library, and the Web of Science, which were accessed between 1990 and 2024. The main search focused on “CE of the liver.” The following terms were used: cystic echinococcosis, hydatidosis, <em>E granulosus</em>, echinococcus life cycle, liver cyst, albendazole, liver resection, pericystectomy, cystobiliary fistula, and percutaneous aspiration injection and reaspiration (PAIR).</div></div><div><h3>Results</h3><div>CE should be considered in the differential diagnosis of hepatic cysts, especially among individuals with risk factors, such as those who have traveled to or immigrated from areas with a high prevalence. Echinococcus species require 2 hosts to complete their life cycle, with humans acting as intermediate hosts that become infected by ingesting eggs from contaminated environments, leading to cyst formation, typically in the liver or lungs. Symptoms are based on cyst size and location, such as abdominal pain, jaundice, respiratory distress, or neurologic deficits, and can lead to severe complications, such as cyst rupture, allergic reactions, sepsis, or secondary hydatidosis. Imaging plays a key role in evaluating cyst stage, size, location, and potential complications and in determining the appropriateness of a minimally invasive PAIR procedure. Although serum antibody tests typically have a low sensitivity, antigen assays or recombinant proteins may provide useful diagnostic information. For uncomplicated active cysts, the treatment options include chemotherapy alone or in combination with the PAIR technique.</div></div><div><h3>Conclusion</h3><div>Hepatic echinococcal cysts, which are relatively rare in North America, should be considered in the differential diagnosis of hepatic cysts, especially in individuals with risk factors.</div></div>","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 3","pages":"Article 101974"},"PeriodicalIF":2.2,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Gastrointestinal Surgery
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