Journal of Gastrointestinal Surgery最新文献

{"title":"Resectable gastric cancer: should we apply a tailored surgical strategy according to microsatellite status?","authors":"Edoardo Maria Muttillo ,&nbsp;Leonardo Di Cicco ,&nbsp;Alice La Franca ,&nbsp;Alessio Lucarini ,&nbsp;Giulia Arrivi ,&nbsp;Francesco Saverio Li Causi ,&nbsp;Giorgio Castagnola ,&nbsp;Andrea Scarinci ,&nbsp;Emanuela Pilozzi ,&nbsp;Federica Mazzuca ,&nbsp;Genoveffa Balducci ,&nbsp;Roberto Luca Meniconi ,&nbsp;Giuseppe Maria Ettorre ,&nbsp;Paolo Mercantini","doi":"10.1016/j.gassur.2024.101890","DOIUrl":"10.1016/j.gassur.2024.101890","url":null,"abstract":"<div><h3>Background</h3><div>High microsatellite instability (MSI) represents a small subgroup of gastric cancer (GC) with favorable prognostic and predictive significance. This study aimed to investigate locoregional lymph node (LN) involvement, overall survival (OS), disease-free survival (DFS), and the interplay between molecular subtypes and histologic profiles regarding survival outcomes in MSI GC vs microsatellite stability (MSS) GC.</div></div><div><h3>Methods</h3><div>This study included 72 patients with GC who underwent surgery with or without chemotherapy from 2017 to 2023. Clinicopathologic characteristics, OS, and DFS were compared between LN-positive and LN-negative patients stratified by microsatellite status, treatments, molecular profiles, and tumor cell types.</div></div><div><h3>Results</h3><div>MSI GC was more common in older patients (79.0 vs 70.2 years; <em>P</em> &lt;.001), more common in females (73.68% vs 43.32%; <em>P</em> =.023), and associated with intestinal-type histology (94.5% vs 49.0%; <em>P</em> =.002). Positive LN involvement and lymphovascular invasion (LVI) were lower in the MSI group than in the MSS group (positive LN: 2.73 vs 4.15, respectively; <em>P</em> =.366; LVI: 36.8% vs 64.5%, respectively; <em>P</em> =.039). Patients with MSI showed slightly better OS and DFS than those with MSS (OS: 84.20% vs 66.00%, respectively; <em>P</em> =.108; DFS: 84.62% vs 63.89%, respectively; <em>P</em> =.120). In addition, compared with patients with MSS GC, those with MSI GC had improved OS and DFS in the LN-positive group (OS: 72.7% vs 61.3%, respectively; <em>P</em> =.255; DFS: 75.0% vs 50.0%, respectively; <em>P</em> =.148) and LN-negative group (OS: 100.0% vs 85.7%, respectively; <em>P</em> =.149; DFS: 100.0% vs 85.7%, respectively; <em>P</em> =.376). In patients not receiving chemotherapy, the MSI/intestinal-type group had the highest OS and DFS (77.0% and 87.5%, respectively; <em>P</em> =.024), whereas the MSS/mixed-type group had the lowest OS and DFS (25.0% and 100.0%, respectively; <em>P</em> =.290). In patients receiving chemotherapy, the MSI/intestinal-type group had the highest OS and DFS (100.0% and 100.0%, respectively; <em>P</em> =.741), whereas the MSS/mixed-type group had the lowest OS and DFS (66.7% and 50.0%, respectively; <em>P</em> =.397).</div></div><div><h3>Conclusion</h3><div>First, patients with MSI GC have a significantly lower risk of locoregional LN involvement and better OS and DFS than those with MSS GC. Second, treatment responses differ based on MSI status: patients with MSI tumors benefit more from upfront surgical interventions, whereas those with MSS, particularly mixed histotypes, demonstrate improved outcomes with preoperative chemotherapy. These results advocate for a tailored therapeutic approach that considers microsatellite status, Lauren classification, and patient clinical conditions.</div></div>","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101890"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Castleman disease masquerading as a retroperitoneal mass with dense calcification","authors":"Abdeali Saif Arif Kaderi ,&nbsp;Gauri Deshpande ,&nbsp;Shraddha Patkar","doi":"10.1016/j.gassur.2024.101901","DOIUrl":"10.1016/j.gassur.2024.101901","url":null,"abstract":"","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101901"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited commentary on thrombosis and anticoagulation after portal vein resection during pancreatic surgery: a systematic review","authors":"Epameinondas Dogeas,&nbsp;Michael A. Choti","doi":"10.1016/j.gassur.2024.101900","DOIUrl":"10.1016/j.gassur.2024.101900","url":null,"abstract":"","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101900"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous origin of the posterior superior pancreaticoduodenal artery: critical vascular variations in the field of hepato-pancreato-biliary surgery","authors":"Yuki Okazoe,&nbsp;Hiroaki Yanagimoto,&nbsp;Daisuke Tsugawa,&nbsp;Masayuki Akita,&nbsp;Hirochika Toyama,&nbsp;Masahiro Kido,&nbsp;Takumi Fukumoto","doi":"10.1016/j.gassur.2024.101926","DOIUrl":"10.1016/j.gassur.2024.101926","url":null,"abstract":"","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101926"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of ileal stricture and gastrointestinal bleeding caused by ectopic pancreas","authors":"Xiaoyi Zhao,&nbsp;Qiang Zhan,&nbsp;Zhongxia Chen","doi":"10.1016/j.gassur.2025.101982","DOIUrl":"10.1016/j.gassur.2025.101982","url":null,"abstract":"","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 4","pages":"Article 101982"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization technology-assisted laparoscopic left hemihepatectomy plus biliary reconstruction for complex biliary dilatation: combined caudoperipheral approach with craniodorsal approach","authors":"Xinci Li ,&nbsp;Kangwei Guo ,&nbsp;Jian Yang","doi":"10.1016/j.gassur.2024.101894","DOIUrl":"10.1016/j.gassur.2024.101894","url":null,"abstract":"","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101894"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant esophageal lipoma","authors":"Dan-Ni Li ,&nbsp;Zhou Li ,&nbsp;Zhi-Ren Wang","doi":"10.1016/j.gassur.2024.101924","DOIUrl":"10.1016/j.gassur.2024.101924","url":null,"abstract":"","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101924"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GI Surgery Summit white paper: recruiting and training the next generation of surgeons","authors":"Jenny H. Chang ,&nbsp;Kelsey Romatoski ,&nbsp;Madeline B. Torres ,&nbsp;Cyrus John Sholevar ,&nbsp;Brenessa Lindeman ,&nbsp;Cameron Gaskill ,&nbsp;Callisia N. Clark ,&nbsp;Flavio Rocha ,&nbsp;Taylor S. Riall ,&nbsp;Jennifer F. Tseng ,&nbsp;Jennifer S. Davids ,&nbsp;Timothy M. Pawlik ,&nbsp;R. Matthew Walsh","doi":"10.1016/j.gassur.2024.101896","DOIUrl":"10.1016/j.gassur.2024.101896","url":null,"abstract":"<div><h3>Background</h3><div>There is an ongoing debate on surgical training and its evolution to meet the demands of a complex and changing healthcare environment.</div></div><div><h3>Methods</h3><div>A GI Surgery Summit was held in January 2024 that included prominent leaders and rising talents from the Society for Surgery of the Alimentary Tract, Society of Surgical Oncology, Association for Academic Surgery, and Society of University Surgeons. This meeting was held to address the multifaceted current and future challenges of surgery.</div></div><div><h3>Results</h3><div>This paper addresses the topic of recruitment and training of the next generation of surgeons in the United States and abroad and reflects a collective focus on surgical education to ensure the delivery of high-quality care in an increasingly sophisticated medical and surgical landscape.</div></div><div><h3>Conclusion</h3><div>The discussions and recommendations from the 2024 GI Surgery Summit underscore the crucial need to support diversity, embrace innovative educational frameworks, build a robust global surgical workforce, and foster a culture of wellness and support. Focusing on these key areas ensures that the future leaders of surgery are not only skilled and knowledgeable but also resilient and compassionate, ready to meet the evolving challenges of the healthcare landscape.</div></div>","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101896"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of radiomics features extracted from baseline computed tomography images in predicting overall survival in patients with nonsurgical pancreatic ductal adenocarcinoma: incorporation of a radiomics score to a multiparametric nomogram to predict 1-year overall survival","authors":"Seyedeh Panid Madani ,&nbsp;Mohammad Mirza-Aghazadeh-Attari ,&nbsp;Alireza Mohseni ,&nbsp;Shadi Afyouni ,&nbsp;Ghazal Zandieh ,&nbsp;Haneyeh Shahbazian ,&nbsp;Ali Borhani ,&nbsp;Iman Yazdani Nia ,&nbsp;Daniel Laheru ,&nbsp;Timothy M. Pawlik ,&nbsp;Ihab R. Kamel","doi":"10.1016/j.gassur.2024.101882","DOIUrl":"10.1016/j.gassur.2024.101882","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to determine the value of radiomics features derived from baseline computed tomography (CT) scans and volumetric measurements to predict overall survival (OS) in patients with nonsurgical pancreatic ductal adenocarcinoma (PDAC) treated with a chemotherapy combination regimen of 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX).</div></div><div><h3>Methods</h3><div>In this retrospective single-institution study, 131 patients with nonsurgical PDAC who received FOLFIRINOX neoadjuvant chemotherapy between December 2012 and November 2021 were included. Pretreatment contrast-enhanced CT images were obtained for all patients before inclusion. The primary tumor was contoured by an expert radiologist with 25 years of experience. A total of 845 radiomics features, including first-, second-, and higher-order features, were extracted from the total tumor volume. A feature reduction pipeline was used to reduce the dimensionality of the data. The selected features were used to generate a radiomics score based on the Least Absolute Shrinkage and Selection Operator coefficients. A high-dimensional Cox model was generated on the basis of the radiomics score and other quantitative and semantic imaging findings.</div></div><div><h3>Results</h3><div>From the 845 radiomics features extracted, 45 were significantly different between the tertiles. The following equation was used to generate a radiomics score: radiomics score = SmallAreaEmphasis (−66.87801 + LargeDependenceEmphasis) − 0.2345916. The radiomics score was significantly different among the 3 groups of the radiomics features (<em>P</em> = .034). The overall difference in survival was significant among the 3 groups (<em>P</em> = .02). The nomogram showed good calibration and showed significant differences among the patients when they were classified as tertiles (<em>P</em> &lt; .00).</div></div><div><h3>Conclusion</h3><div>Radiomics approaches have the potential to predict OS in nonsurgical patients with PDAC, and the inclusion of semantic imaging findings and pathologic data could further enhance prognostication in patients with PDAC.</div></div>","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101882"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metachronous gastric metastasis from clear cell renal cell carcinoma presenting with gastrointestinal bleeding","authors":"Abdeali Saif A. Kaderi,&nbsp;Amandeep Arora,&nbsp;Manish Suresh Bhandare","doi":"10.1016/j.gassur.2024.101891","DOIUrl":"10.1016/j.gassur.2024.101891","url":null,"abstract":"","PeriodicalId":15893,"journal":{"name":"Journal of Gastrointestinal Surgery","volume":"29 2","pages":"Article 101891"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}