Journal of Magnetic Resonance Imaging最新文献

英文中文

IDH Mutation Classification in Nonenhancing Gliomas: A Comparison of Habitat and Whole-Tumor Transfer Learning Strategies. 非增强胶质瘤中IDH突变分类：栖息地和全肿瘤转移学习策略的比较。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-22 DOI: 10.1002/jmri.70187

Yu Han, Yuyao Wang, Wuxun Cui, Sijie Xiu, Yang Yang, Jin Zhang

Background: Isocitrate dehydrogenase (IDH) mutation status is an important biomarker for the diagnosis and management of nonenhancing gliomas, underscoring the need for noninvasive preoperative classification.

Purpose: To compare the value of habitat-based and whole-tumor strategies in classifying IDH mutation status in nonenhancing gliomas via transfer learning on structural magnetic resonance imaging and subtraction images.

Study type: Retrospective.

Population: Two-hundred and eighty-four patients with nonenhancing gliomas, divided into a training set (n = 198; 44 ± 12 years; 83 females) and a testing set (n = 86; 46 ± 11 years; 35 females).

Field strength/sequence: 3T, fluid-attenuated inversion recovery (FLAIR), fast spin-echo (FSE) T2-weighted imaging (T2WI), FSE T1-weighted imaging (T1WI), contrast-enhanced FSE T1-weighted imaging (T1CE).

Assessment: Based on FLAIR, T2WI, T1WI, T1CE, and subtraction images, two regions of interest input strategies were applied to construct transfer learning models, including whole-tumor strategy and habitat-based strategy. Model performance was evaluated using the area under curves (AUC) and accuracy (ACC). Finally, the optimal model was combined with clinical variables to develop integrative models.

Statistical tests: Continuous variables were analyzed by Student's t test or Wilcoxon rank-sum test; categorical variables by χ² test or Fisher's exact test. Two-sided p < 0.05 was statistically significant.

Results: In the whole-tumor strategy, the subtraction model demonstrated significantly superior performance, achieving training and testing set AUC/ACC of 0.850/0.813 and 0.890/0.884. The habitat-based strategy significantly outperformed the whole-tumor strategy, with the T2WI model demonstrating optimal efficacy (training set, AUC/ACC = 0.898/0.899; testing set, AUC/ACC = 0.870/0.849). The integrative model (habitat-based T2WI + Age + Location) achieved the highest classification performance, with AUCs of 0.923 and 0.947 in the training and testing sets, respectively.

Data conclusion: The habitat-based strategy outperforms the whole-tumor approach, with the habitat-based T2WI model achieving optimal classification performance. Integrating age and tumor location into this model can further boost its classification capability.

Level of evidence: 3:

Technical efficacy: Stage 2.

背景：异柠檬酸脱氢酶（IDH）突变状态是非增强型胶质瘤诊断和治疗的重要生物标志物，强调术前无创分类的必要性。目的：比较基于栖息地策略和全肿瘤策略在结构磁共振成像和减影图像上的迁移学习对非增强胶质瘤中IDH突变状态的分类价值。研究类型：回顾性。人群：284例非增强性胶质瘤患者，分为训练组（n = 198； 44±12岁；女性83例）和测试组（n = 86； 46±11岁；女性35例）。场强/序列：3T、流体衰减反演恢复（FLAIR）、快速自旋回波（FSE） t2加权成像（T2WI）、FSE t1加权成像（T1WI）、对比增强FSE t1加权成像（T1CE）。评估：基于FLAIR、T2WI、T1WI、T1CE和减法图像，采用两种兴趣区域输入策略构建迁移学习模型，包括全肿瘤策略和基于栖息地的策略。使用曲线下面积（AUC）和精度（ACC）来评估模型的性能。最后，将优化后的模型与临床变量相结合，形成综合模型。统计检验：采用Student’st检验或Wilcoxon秩和检验对连续变量进行分析；通过χ2检验或费雪确切检验。双侧p结果：在全肿瘤策略中，减法模型表现出明显的优势，训练集和测试集AUC/ACC分别为0.850/0.813和0.890/0.884。基于栖息地的策略明显优于全肿瘤策略，T2WI模型效果最佳（训练集，AUC/ACC = 0.898/0.899；测试集，AUC/ACC = 0.870/0.849）。综合模型（基于栖息地的T2WI +年龄+位置）的分类性能最高，训练集和测试集的auc分别为0.923和0.947。数据结论：基于栖息地的策略优于全肿瘤方法，其中基于栖息地的T2WI模型具有最佳的分类性能。在模型中加入年龄和肿瘤位置可以进一步提高模型的分类能力。证据等级：3；技术功效：第二阶段。

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引用次数: 0

Editorial for “Development and Deployment of a Machine Learning Model to Triage the Use of Prostate MRI (ProMT-ML) in Patients With Suspected Prostate Cancer” “开发和部署一种机器学习模型，对疑似前列腺癌患者进行前列腺MRI （ProMT-ML）分类”的社论。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-22 DOI: 10.1002/jmri.70190

Feng Xu, Yu-Dong Zhang

引用次数: 0

Editorial for “Safety of MRI Examinations Under Sedation: A Nationwide Survey in Japan” 社论“镇静下核磁共振检查的安全性：日本全国调查”。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-20 DOI: 10.1002/jmri.70181

Pia Sanpitak

引用次数: 0

T2-Weighted T1 Mapping and Automated Segmentation of CSF: Assessment of Solute Gradients in the Healthy Brain. t2 -加权T1映射和脑脊液自动分割：健康大脑溶质梯度的评估。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-18 DOI: 10.1002/jmri.70169

Tryggve Holck Storås, Sofie Lysholm Lian, Ingrid Mossige, Jørgen Riseth, Siri Fløgstad Svensson, Grethe Løvland, Geir Ringstad, Kent-André Mardal, Kyrre Eeg Emblem, Kaja Nordengen

Background: Cerebrospinal fluid (CSF) serves as a medium for nutrient delivery and waste clearance. The T1 relaxation rate, R1, can be used to measure the concentration of intrinsic solutes and extrinsic contrast agents.

Purpose: To implement a method for R1 mapping and segmentation of CSF and to use this method to explore how R1 of CSF relates to protein content and gadobutrol after intrathecal administration.

Study type: Prospective cohort study, complemented by phantom analysis.

Population: Ten healthy control subjects (mean age 65.5 ± 4.4 years, range 57-72 years; five males and five females) and protein- and gadobutrol-gradient phantom.

Field strength/sequence: 3 T Philips Ingenia scanner; 3D T2W mixed inversion recovery spin-echo (T2W-mixed IRSE) sequence and 3D T1W turbo field echo (3D T1W-TFE).

Assessment: R1 maps were calculated by combining IR and SE data. An automated segmentation method derived from FreeSurfer employed SE data for CSF segmentation and T1W-TFE for anatomical reference. CSF was collected by lumbar puncture for protein measurements, and 0.25 mmol gadobutrol was injected intrathecally. Post-contrast assessments were performed at 3, 24, 48, and 72 h.

Statistical tests: One-way ANOVA, followed by a post hoc Tukey HSD test, and simple and multiple linear regression analysis; significance level of 0.05.

Results: R1 of ventricular CSF 0.216 ± 0.001 s^-1 was significantly lower than that surrounding the cerebellum 0.225 ± 0.001 and cerebrum 0.228 ± 0.002 and correlated with lumbar protein concentration (R² = 0.56). Peak gadobutrol concentrations were 101 ± 84 μM in ventricles, 185 ± 89 μM in cerebellar SAS and 166 ± 91 μM in cerebral SAS. Corresponding concentrations were 6 ± 4, 17 ± 8, and 37 ± 18 μM at 72 h.

Data conclusion: Intrinsic R1 of CSF in the subarachnoid space correlated with protein content. Intracranial CSF enrichment after intrathecal administration of gadobutrol showed a large variation among healthy volunteers.

Evidence level: 2.

Technical efficacy: 3.

背景：脑脊液（CSF）是营养物质输送和废物清除的介质。T1弛豫速率R1可以用来测量固有溶质和外在对比剂的浓度。目的：建立脑脊液R1定位和分割方法，并利用该方法探讨脊髓鞘内给药后脑脊液R1与蛋白含量和gadobutrol的关系。研究类型：前瞻性队列研究，辅以幻影分析。人群：健康对照10例（平均年龄65.5±4.4岁，年龄范围57-72岁，男5女5），蛋白质梯度和gadobutrol梯度幻影。场强/序列：3t Philips Ingenia扫描仪；三维T2W混合反演恢复自旋回波（T2W-mixed IRSE）序列和三维T1W涡轮场回波（3D T1W- tfe）。评价：结合IR和SE数据计算R1图。源自FreeSurfer的自动分割方法采用SE数据进行脑脊液分割，T1W-TFE作为解剖学参考。腰椎穿刺采集脑脊液进行蛋白测定，鞘内注射0.25 mmol gadobutrol。对比后评估分别在3、24、48和72小时进行。统计检验：单因素方差分析、事后Tukey HSD检验、简单和多元线性回归分析；显著性水平0.05。结果：脑脊液R1 0.216±0.001 s-1明显低于小脑周围0.225±0.001和大脑周围0.228±0.002，且与腰椎蛋白浓度相关（R2 = 0.56）。脑室、小脑SAS和脑SAS的峰值浓度分别为101±84 μM、185±89 μM和166±91 μM。72h对应浓度分别为6±4、17±8、37±18 μM。资料结论：蛛网膜下腔脑脊液内征R1与蛋白含量相关。在健康志愿者中，鞘内给予加多布鲁后的颅内脑脊液富集表现出很大的差异。证据等级：2。技术功效：

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引用次数: 0

Editorial for “Incremental Prognostic Value of Cardiac MRI-Based Right-to-Left Ventricular Blood Pool T2 Ratio in Patients With Dilated Cardiomyopathy” “基于心脏mri的左、右心室血池T2比值对扩张型心肌病患者的增量预后价值”的社论。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-18 DOI: 10.1002/jmri.70177

Jin-Yi Xiang, Dong-Aolei An, Lian-Ming Wu

引用次数: 0

Editorial for “Quantitative MRI Values for Atrial and Ventricular Parameters in Altitude-Dwelling Youth: Ethnic and Sex-Specific Differences” “高原青年心房和心室参数的定量MRI值：种族和性别特异性差异”的社论。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-18 DOI: 10.1002/jmri.70174

Steffen E. Petersen, Janek Salatzki

引用次数: 0

Highly Accelerated Aortic 4D Flow MRI: Implications for Pulse Wave Velocity Measurements 高加速主动脉4D血流MRI：脉搏波速度测量的意义。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-14 DOI: 10.1002/jmri.70175

Ethan Johnson, Kelly Jarvis

引用次数: 0

Editorial for “Altered Myocardial Oxygenation and Impaired Energy Efficiency: A Pilot Study in Patients With Light Chain Cardiac Amyloidosis” “心肌氧合改变和能量效率受损：轻链心脏淀粉样变性患者的初步研究”的社论。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-14 DOI: 10.1002/jmri.70173

Evgenia Efthymiou, Nikolaos L. Kelekis

引用次数: 0

Incremental Prognostic Value of Cardiac MRI-Based Right-to-Left Ventricular Blood Pool T2 Ratio in Patients With Dilated Cardiomyopathy 基于心脏mri的左、右心室血池T2比值对扩张型心肌病患者的增量预后价值。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-12 DOI: 10.1002/jmri.70170

Ji Yang, Yajuan Li, Yangzhen Hou, Jing Luo, Yijie Li, Shulin Liu, Hui Zhou

<div> <section> <h3> Background</h3> <p>Blood T2 is sensitive to blood oxygenation level, and right ventricular (RV) oxygenation abnormalities may be detected by the relative difference between T2 values of the left ventricular (LV) and RV blood pools.</p> </section> <section> <h3> Purpose</h3> <p>To investigate the prognostic value of right-to-left ventricular blood pool T2 ratio (RV/LV T2 ratio) in patients with dilated cardiomyopathy (DCM).</p> </section> <section> <h3> Study Type</h3> <p>Retrospective.</p> </section> <section> <h3> Population</h3> <p>Three hundred and eleven patients with DCM (mean age: 52 ± 14.5 years; 72% male) and 30 age- and sex-matched healthy controls.</p> </section> <section> <h3> Field Strength/Sequence</h3> <p>1.5 or 3.0 T, steady-state free precession cine sequence, T2-prepared fast low-angle shot T2 mapping sequence, and phase-sensitive inversion recovery late gadolinium enhancement (LGE) sequence.</p> </section> <section> <h3> Assessment</h3> <p>Clinical characteristics, conventional cardiac MRI parameters (ventricular volumes, function, mass), LGE extent, native myocardial T2, LV and RV strain, and RV/LV T2 ratio were assessed. Patients were followed up for a median duration of 34 months (interquartile range 21–45 months). The primary outcome, major adverse cardiac events (MACE), includes all-cause mortality, heart failure-related hospitalization, heart transplantation, or aborted sudden cardiac death. The incremental prognostic value of RV/LV T2 ratio for MACE was assessed beyond traditional risk factors.</p> </section> <section> <h3> Statistical Tests</h3> <p>The prognostic value of RV/LV T2 ratio was evaluated using multivariable Cox regression analysis and Kaplan–Meier curves. Incremental prognostic value was evaluated using C indices and likelihood ratio tests. A <i>p</i> value < 0.05 was considered significant.</p> </section> <section> <h3> Results</h3> <p>One hundred and twenty-four patients experienced MACE. RV/LV T2 ratio was significantly lower in participants with MACE, and was associated with MACE in patients with DCM, irrespective of LVEF and LGE extent (above or below median value). In Cox analysis, RV/LV T2 ratio was independently associated with MACE (hazard ratio: 1.32 per 0.1 decrease), and provided significant incremental prognostic value beyond traditional

背景：血液T2对血氧水平敏感，通过左室（LV）和右室（RV）血池T2值的相对差值可以检测右室（RV）氧合异常。目的：探讨右左心室血池T2比值（RV/LV T2比值）对扩张型心肌病（DCM）患者的预后价值。研究类型：回顾性。人群：311例DCM患者（平均年龄：52±14.5岁；72%男性）和30例年龄和性别匹配的健康对照。场强/序列：1.5或3.0 T，稳态自由进动影像序列，T2制备快速低角度拍摄T2映射序列，相敏反演恢复晚期钆增强（LGE）序列。评估：评估临床特征、常规心脏MRI参数（心室容积、功能、质量）、LGE程度、原生心肌T2、左室和右室应变、左室/左室T2比值。患者的中位随访时间为34个月（四分位数间21-45个月）。主要结局是主要心脏不良事件（MACE），包括全因死亡率、心力衰竭相关住院、心脏移植或流产的心源性猝死。除了传统的危险因素外，还评估了RV/LV T2比值对MACE的增量预后价值。统计学检验：采用多变量Cox回归分析和Kaplan-Meier曲线评价RV/LV T2比值的预后价值。使用C指数和似然比检验评估增量预后价值。结果：124例患者出现MACE。与LVEF和LGE程度（高于或低于中位数）无关，MACE患者的RV/LV T2比值显著降低，且与DCM患者的MACE相关。在Cox分析中，RV/LV T2比值与MACE独立相关（风险比：1.32 / 0.1），并且在DCM患者中提供了超越传统危险因素的显著增量预后价值。数据结论：在DCM患者中，RV/LV T2比值与MACE独立相关，在与临床和常规MRI危险因素联合的模型中提供了增加的预后价值。证据等级：3。技术功效：5。

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引用次数: 0

Comparison of 5 T and 3 T Biparametric MRI for Clinically Suspected Prostate Cancer: Image Quality, Lesion Visualization, and Artifacts 临床怀疑前列腺癌的5t和3t双参数MRI的比较：图像质量，病变可视化和伪影。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2025-11-12 DOI: 10.1002/jmri.70171

Yunfeng Deng, Guiqin Liu, Jie Chen, Shengyun He, Kai Lu, Xiaobin Wei, Jingli Chen, Mengying Zhu, Yuansheng Luo, Yinjie Zhu, Wei Xue, Guangyu Wu

<div> <section> <h3> Background</h3> <p>Biparametric MRI (bpMRI) is important for prostate cancer (PCa) diagnosis. Higher field strength at 5 T may improve image quality versus 3 T, but clinical value remains unclear.</p> </section> <section> <h3> Purpose</h3> <p>To compare image quality, imaging artifacts, and PCa visualization between 3 T and 5 T bpMRI.</p> </section> <section> <h3> Study Type</h3> <p>Prospective.</p> </section> <section> <h3> Population</h3> <p>One hundred and five patients with clinically suspected PCa, including 56 with histologically proven prostatic lesions.</p> </section> <section> <h3> Field Strength/Sequence</h3> <p>3 T and 5 T; T2-weighted imaging (T2WI) using fast spin echo and echo-planar diffusion-weighted imaging (DWI).</p> </section> <section> <h3> Assessment</h3> <p>Signal-to-noise ratio (SNR) measured at both field strengths; in the biopsy-proven cancer subset, contrast-to-noise ratio (CNR), apparent diffusion coefficient (ADC), and lesion-boundary sharpness measured using the “plot profile” function. Image quality and lesion conspicuity rated on 5-point Likert scales. Prostate imaging reporting and data system (PI-RADS) v2.1 agreement was compared using Cohen <i>κ</i>. Participants were grouped by pre-scan enema (enema <i>n</i> = 61; non-enema <i>n</i> = 44) for artifact comparisons.</p> </section> <section> <h3> Staistical Tests</h3> <p>Wilcoxon signed-rank test, ICC, and Cohen's <i>κ</i>; <i>p</i> < 0.05 was considered significant.</p> </section> <section> <h3> Results</h3> <p>5 T demonstrated significantly higher SNR for T2WI (391.40 vs. 274.41) and DWI (208.82 vs. 106.40). CNR was higher at 5 T for T2WI (median 10.3 vs. 8.5) and DWI (median 31.5 vs. 16.2); lesion-edge sharpness was greater at 5 T (median 48.1%/mm vs. 30.9%/mm). Median scores for image quality, lesion conspicuity, and anatomy visibility were higher at 5 T than at 3 T (4–5 vs. 3–4). DWI artifacts were more frequent at 5 T in the non-enema group (5 T 20%–27% vs. 3 T 11%–16%); other artifact comparisons were not significant (<i>p</i> = 0.059–0.886). PI-RADS scoring showed excellent inter-reader agreement (<i>κ</i> = 0.83–0.95) and good inter-field agreement (<i>κ</i> = 0.69–0.89).</p> </section> <section> <h3> Data Conclusion</h3>

背景：双参数MRI （bpMRI）在前列腺癌（PCa）诊断中具有重要意义。与3t相比，5t更高的场强可能改善图像质量，但临床价值尚不清楚。目的：比较3t和5t bpMRI的图像质量、成像伪影和PCa可视化。研究类型：前瞻性。人群：105例临床怀疑为前列腺癌的患者，其中56例组织学证实为前列腺病变。场强/序列：3t、5t；t2加权成像（T2WI）采用快速自旋回波和回波平面扩散加权成像（DWI）。评估：在两种场强下测量信噪比（SNR）；在活检证实的癌症子集中，使用“plot profile”函数测量对比度-噪声比（CNR）、表观扩散系数（ADC）和病变边界清晰度。图像质量和病变显著性以5分李克特量表评定。采用Cohen κ比较前列腺影像学报告与数据系统（PI-RADS） v2.1一致性。参与者按扫描前灌肠分组（灌肠n = 61；非灌肠n = 44）进行伪影比较。统计检验：Wilcoxon sign -rank检验、ICC、Cohen’s κ；p结果：5t显示T2WI（391.40比274.41）和DWI（208.82比106.40）的信噪比明显更高。T2WI（中位数10.3 vs. 8.5）和DWI（中位数31.5 vs. 16.2）的CNR在5 T时更高；病变边缘锐度在5 T时更高（中位数48.1%/mm vs. 30.9%/mm）。图像质量、病变显著性和解剖可见性的中位数分数在5t时高于3t（4-5比3-4）。未灌肠组5t时DWI伪影更常见（5t 20%-27% vs. 3t 11%-16%）；其他伪影比较不显著（p = 0.059-0.886）。PI-RADS评分显示良好的读者间一致性（κ = 0.83-0.95）和良好的场间一致性（κ = 0.69-0.89）。数据结论：在bpMRI中，5t的T2WI和DWI图像质量明显优于3t。证据等级：2。技术功效：第3阶段。

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