Journal of Magnetic Resonance Imaging最新文献_第9页

Optic Nerve MRI Signal Alterations in Dural Arteriovenous Fistulae: Correlations With Papilledema and Visual Decline. 硬脑膜动静脉瘘视神经MRI信号改变：与乳头水肿和视力下降的关系。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-30 DOI: 10.1002/jmri.70250

Adarsh Anil Kumar, Santhosh Kumar Kannath, Jayadevan Enakshy Rajan, Jineesh Valakkada, Bejoy Thomas, Chandrasekharan Kesavadas

Background: Visual decline in dural arteriovenous fistulae (DAVF) patients is attributed to venous hypertension, raised intracranial pressure and resultant optic nerve axoplasmic flow stasis. Objective imaging biomarkers for optic nerve involvement are however limited.

Purpose: To determine whether 3D fluid attenuated inversion recovery (FLAIR) optic nerve signal intensity ratio (SIR) is associated with papilledema and visual deterioration in DAVF patients.

Study type: Single-center retrospective observational study.

Population: 54 digital subtraction angiography (DSA) confirmed DAVF patients (27 with papilledema; 27 without) with 3D FLAIR MRI, together with 27 matched controls.

Field strength/sequence: 3D FLAIR sequence at 3.0 T.

Assessment: Three blinded neuroradiologists evaluated segmental normalized optic-nerve SIR. The primary outcome was status of papilledema (fundoscopy)/visual deterioration (Snellen's visual acuity charting). Secondary outcomes included segmental optic nerve hyperintensity (measured by SIR and qualitative assessment) and visual response (improved, stable or worsened visual acuity) post-embolization. All patients underwent endovascular embolization with repeat neuro-ophthalmologic evaluation and imaging (short term followup at 1 month and long term at 1 year).

Statistical tests: Unpaired t-test, Mann-Whitney U, repeated-measures ANOVA, Receiver Operating Characteristic (ROC) curve; Interobserver agreement with Krippendorff's alpha and intraclass correlation coefficient (ICC); Correlation analysis with Spearman correlation; p value < 0.05 was considered significant.

Results: Optic nerve SIR differed significantly across groups, with highest values in patients with visual decline. The intracanalicular segment was most commonly involved (51.8%). An SIR cutoff of 1.7 showed association of papilledema with visual loss (AUC = 0.725; 95% CI: 0.608-0.858; 48.2% had visual deterioration), yielding 79.2% sensitivity and 63.3% specificity. Follow-up included repeat ophthalmologic evaluation and imaging, with 23.1% patients showing improvement at a mean follow-up of 1.7 ± 1.6 years.

Conclusion: 3D FLAIR MRI may detect optic nerve signal changes in DAVF patients, with elevated intracanalicular SIR correlating with papilledema and visual decline.

Evidence level: 4.

Technical efficacy: Stage 5.

背景：硬脑膜动静脉瘘（DAVF）患者的视力下降是由于静脉高压、颅内压升高和由此引起的视神经轴浆血流停滞。然而，视神经受累的客观成像生物标志物有限。目的：探讨三维液体衰减反转恢复（FLAIR）视神经信号强度比（SIR）与DAVF患者乳头水肿和视力恶化是否相关。研究类型：单中心回顾性观察性研究。人群：54例数字减影血管造影（DSA）证实的DAVF患者（27例有乳头状水肿，27例无）与27例匹配的对照。场强/序列：3.0 t的3D FLAIR序列评估：三位盲法神经放射学家评估节段标准化视神经SIR。主要结果是乳头水肿（眼底镜检查）/视力恶化（Snellen视力表）的状态。次要结果包括栓塞后视神经节段性高强度（由SIR测量和定性评估）和视觉反应（视力改善、稳定或恶化）。所有患者均行血管内栓塞术，并进行重复神经眼科评估和影像学检查（短期随访1个月，长期随访1年）。统计检验：未配对t检验、Mann-Whitney U检验、重复测量方差分析、受试者工作特征（ROC）曲线；观察者间对Krippendorff α和类内相关系数（ICC）的一致性；Spearman相关分析；结果：视神经SIR值组间差异显著，以视力下降组最高。椎管内段最常受累（51.8%）。SIR截断值为1.7，显示乳头水肿与视力下降有关（AUC = 0.725; 95% CI: 0.608-0.858； 48.2%的患者视力下降），敏感性为79.2%，特异性为63.3%。随访包括重复眼科评估和影像学检查，23.1%的患者在平均1.7±1.6年的随访中表现出改善。结论：3D FLAIR MRI可检测到DAVF患者视神经信号的改变，管内SIR升高与视神经乳头水肿和视力下降相关。证据等级：4。技术功效：第5阶段。

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引用次数: 0

Comparison of Single-Breath and Multi-Breath Xe-MRI in the Longitudinal Assessment of Treatment in Children With Cystic Fibrosis. 单次呼吸与多次呼吸x - mri在儿童囊性纤维化治疗纵向评估中的比较。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-29 DOI: 10.1002/jmri.70242

Faiyza S Alam, Samal Munidasa, Brandon Zanette, Daniel Li, Sharon Braganza, Felix Ratjen, Giles Santyr

Background: Elexacaftor/tezacaftor/ivacaftor (ETI) is a current standard therapy for pediatric cystic fibrosis (CF). Multiple-breath washout ¹²⁹Xe MRI (MBW Xe-MRI) is improved following 1 month of treatment. However, the utility of MBW Xe-MRI over extended ETI treatment and its comparison to single-breath Xe-MRI and pulmonary function tests (PFTs) in monitoring disease progression remains unclear.

Purpose: To compare MBW Xe-MRI and single-breath Xe-MRI in a small pediatric CF cohort at 1, 6, 12, and 24 months post-ETI initiation.

Study type: Prospective longitudinal cohort study.

Subjects: 14 participants (7 female, median age 15.5 [14, 17] years) with CF undergoing ETI.

Field strength/sequence: Xe-MRI using a gradient echo sequence at 3T.

Assessment: A total of 12 participants completed MBW Xe-MRI, single-breath Xe-MRI, and PFTs (spirometry, N₂ MBW) at ≥ 2 of 4 visits (1, 6, 12, and 24 months post-ETI). Fractional ventilation (FV) and FV coefficient of variation (CoV_FV) maps were calculated from MBW Xe-MRI. Ventilation defect percent (VDP) was calculated from single-breath Xe-MRI.

Statistical tests: Longitudinal changes were analyzed using a linear mixed-effects model (fixed effect: time, random intercept: participant). Significance via ANOVA F-test, p < 0.05. Intra-class correlation coefficients (ICC) were used to quantify between- and within-subject variability.

Results: Data completeness (total number of acquired data points divided by expected data points across 14 participants, 4 visits) was ≥ 75%. While PFTs/VDP remained stable over 24 months (ICC ≥ 0.93; linear mixed-effects model of time effect for ppFEV₁, LCI and VDP was not significant with p = 0.68, 0.13 and 0.12, respectively), CoV_FV demonstrated a small but significant increase (slope magnitude +0.001/month). Furthermore, two participants had elevated CoV_FV despite normal VDP. Finally, MBW Xe-MRI metrics showed higher within-subject variability than PFTs/VDP (ICC: FV = 0.41, CoV_FV = 0.55 vs. VDP/PFTs ≥ 0.92).

Data conclusion: CoV_FV may continue to evolve over 2 years in pediatric CF patients receiving ETI, particularly in individuals with persistent ventilation defects.

Evidence level: 1.

Stage of technical efficacy: 2.

背景：Elexacaftor/tezacaftor/ivacaftor （ETI）是目前儿童囊性纤维化（CF）的标准治疗方法。治疗1个月后，多次呼吸冲洗129Xe MRI （MBW Xe-MRI）改善。然而，MBW x - mri在延长ETI治疗中的应用及其与单呼吸x - mri和肺功能检查（pft）在监测疾病进展方面的比较仍不清楚。目的：比较eti开始后1、6、12和24个月的MBW x - mri和单呼吸x - mri在一个小型儿科CF队列中的应用。研究类型：前瞻性纵向队列研究。受试者：14名CF患者（7名女性，中位年龄15.5[14,17]岁）接受ETI。场强/序列：x - mri使用3T梯度回波序列。评估：共有12名参与者在4次就诊（eti后1、6、12和24个月）中至少2次完成MBW x - mri、单次呼吸x - mri和PFTs（肺活量测定，N2 MBW）。通过MBW x - mri计算分数通气量（FV）和FV变异系数（CoVFV）图。单次呼吸x - mri计算通气缺陷百分率（VDP）。统计检验：采用线性混合效应模型（固定效应：时间，随机截距：参与者）分析纵向变化。结果：数据完整性（14名参与者4次就诊中获得的总数据点除以预期数据点）≥75%。虽然PFTs/VDP在24个月内保持稳定(ICC≥0.93；时间效应的线性混合效应模型对ppFEV1、LCI和VDP的影响不显著（p分别为0.68、0.13和0.12），但CoVFV呈小而显著的增加（斜率值+0.001/月）。此外，两名参与者尽管VDP正常，但冠状病毒感染升高。最后，MBW Xe-MRI指标显示受试者内变异性高于PFTs/VDP （ICC: FV = 0.41, CoVFV = 0.55, VDP/PFTs≥0.92）。数据结论：CoVFV可能在接受ETI的儿科CF患者中持续发展超过2年，特别是在持续通气缺陷的个体中。证据等级：1。技术功效阶段：

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引用次数: 0

Exploring the Dynamics of Ischemia and Reactive Hyperemia With Skeletal Muscle Blood Oxygen Level Dependent MRI in Patients With Peripheral Artery Disease, Age-Matched Controls, and Young Healthy Subjects 外周动脉疾病患者、年龄匹配对照组和年轻健康受试者的骨骼肌血氧水平依赖MRI探讨缺血和反应性充血的动力学

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-28 DOI: 10.1002/jmri.70204

Jonathan Arvidsson, Stefanie Eriksson, Oscar Jalnefjord, Edvin Johansson, Joakim Nordanstig, Kerstin Lagerstrand

<div> <section> <h3> Background</h3> Skeletal muscle blood oxygen level dependent (BOLD) MRI is a technique for assessing vascular function in peripheral limbs. In patients, however, an increased frequency of atypical response patterns has been observed, warranting investigation into its underlying causes. </section> <section> <h3> Purpose</h3> To explore the dynamics of cuff-induced ischemia and reactive hyperemia with BOLD MRI, focusing on the occurrence, quantification, and interpretation of frequent atypical cuff-induced response patterns. </section> <section> <h3> Study Type</h3> Secondary assessment of prospectively collected datasets. </section> <section> <h3> Population</h3> Seventeen peripheral artery disease (PAD) patients (age: 64–80 years, ankle-brachial index (ABI) range: 0.4–0.8), 8 age-matched controls (age: 64–82 years, ABI range: 1–1.2), and 14 young controls (age: 22–39 years). </section> <section> <h3> Field Strength/Sequence</h3> <math> <semantics> <mrow> <msubsup> <mi>T</mi> <mn>2</mn> <mo>*</mo> </msubsup> </mrow> </semantics> </math>-weighted multi-echo gradient-echo sequence with 11 equidistant echo-times at 3T. </section> <section> <h3> Assessment</h3> A transverse slice of the calf was imaged repeatedly during an upper-thigh cuff compression cycle consisting of 1-min baseline, 5-min arterial occlusion (cuff inflated) and 5-min reactive hyperemia (cuff deflated). <math> <semantics> <mrow> <msubsup> <mi>T</mi> <mn>2</mn> <mo>*</mo> </msubsup>

背景：骨骼肌血氧水平依赖（BOLD） MRI是一种评估外周肢体血管功能的技术。然而，在患者中，观察到非典型反应模式的频率增加，需要对其潜在原因进行调查。目的：利用BOLD MRI探讨袖带诱导的缺血和反应性充血的动力学，重点研究频繁出现的非典型袖带诱导的反应模式的发生、量化和解释。研究类型：前瞻性收集数据集的二次评估。人群：17例外周动脉疾病（PAD）患者（年龄：64-80岁，踝肱指数（ABI）范围：0.4-0.8），8例年龄匹配的对照（年龄：64-82岁，ABI范围：1-1.2），14例年轻对照（年龄：22-39岁）。场强/序列：t2 * $$ {T}_2^{ast } $$ -加权多回波梯度回波序列，在3T具有11等距回波时间。评估：在大腿上袖带压缩周期（包括1分钟基线、5分钟动脉闭塞（袖带充气）和5分钟反应性充血（袖带充气））期间，反复对小腿横切面进行成像。t2 * $$ {T}_2^{ast } $$ -映射与ROI-wise分析比目鱼和腓肠肌产生t2 * $$ {mathrm{T}}_2^{ast } $$时间曲线和先前建立的指标，包括充血上坡（HS up $$ {mathrm{HS}}_{mathrm{up}}operatorname{} $$）和峰值时间（TTP）进行评估。对时间曲线进行了调查，以确定偏离预期的频率和类型。通过拟合参数化函数进一步分析比目鱼肌的T2* $$ {mathrm{T}}_2^{ast } $$时间曲线，得出附加指标，包括袖带释放时的下突深度和单调T2*下降的偏差。踝肱指数（Ankle-brachial index， ABI）作为临床比较参考。统计检验：非参数双尾Wilcoxon秩和检验，评估患者与年龄匹配对照之间的差异。结果：非典型袖带诱导的PAD患者反应模式包括阴性袖带诱导的短暂性(42%, soleus) and non-monotonic declines in T 2 * $$ {T}_2^{ast } $$ during cuffing (58%, soleus). While these contributed to increased variabilities in patients, there were significant differences in HS up $$ mathrm{there} mathrm{were} mathrm{significant} mathrm{differences} mathrm{in} {mathrm{HS}}_{mathrm{up}} $$ (-0.63 ms/s) and TTP (62.8 s) between patients and age-matched controls.Data conclusion: HSup and TTP provided means to quantify calf muscle responses to cuffing. Specific cases of non-monotonous T 2 * $$ {T}_2^{ast } $$ decrease during cuffing suggest the detection of venous valve leakages in inter-muscular veins. Insufficient cuff pressure produced curves with absent ischemic plateau and weak hyperemic responses, the recognition of which is important to prevent physiological misinterpretations of T 2 * - time $$ {mathrm{T}}_2^{ast }-mathrm{time} $$ curves and derived metrics.Evidence level: 1.Technical efficacy: 3.

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引用次数: 0

Editorial for “Exploring the Dynamics of Ischemia and Reactive Hyperemia With Skeletal Muscle Blood Oxygen Level Dependent MRI in Patients With Peripheral Artery Disease, Age-Matched Controls, and Young Healthy Subjects” 《利用骨骼肌血氧水平依赖MRI研究外周动脉疾病患者、年龄匹配对照组和年轻健康受试者的缺血和反应性充血动力学》的社论。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-28 DOI: 10.1002/jmri.70202

Hui Tang, Shiteng Suo

引用次数: 0

Editorial to "Enhancing Study Design and Analysis of MR Imaging Markers Through Measurement Error Modeling". “通过测量误差建模加强磁共振成像标记物的研究设计和分析”的社论。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-24 DOI: 10.1002/jmri.70245

Xiao Wu, Hao Wang

引用次数: 0

Editorial for "Outcome Assessment in Stroke Using Multiparametric MRI: Integrating Infarct Location, Radiomics, and Global Brain Frailty". 《脑卒中多参数MRI结果评估：整合梗死位置、放射组学和整体脑脆弱性》的社论。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-24 DOI: 10.1002/jmri.70246

Tao Li, Lei Zhang, Hongwei Zhou

引用次数: 0

Editorial for "Cardiac MR Fingerprinting at 0.55T Using a Deep Image Prior for Joint T₁, T₂, and M₀ Mapping". “在0.55T下使用深度图像先验进行关节T1， T2和M0映射的心脏MR指纹识别”的社论。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-22 DOI: 10.1002/jmri.70240

Yiwen Gong, Haikun Qi, Sha Hua

引用次数: 0

Cardiac MR Fingerprinting at 0.55T Using a Deep Image Prior for Joint T₁, T₂, and M₀ Mapping. 使用深度图像先验进行关节T1， T2和M0映射的0.55T心脏MR指纹识别。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-22 DOI: 10.1002/jmri.70239

Zhongnan Liu, Zexuan Liu, Imran Rashid, Mauricio Stanzione Galizia, Christopher Scoma, William Truesdell, Prachi Agarwal, Nicole Seiberlich, Liyue Shen, Jesse Hamilton

Background: 0.55T systems offer unique advantages and may support expanded access to cardiac MRI.

Purpose: To assess the feasibility of 0.55T cardiac MR Fingerprinting (MRF), leveraging a deep image prior reconstruction to mitigate noise.

Study type: Phantom and prospective in vivo assessment.

Population: ISMRM/NIST MRI system phantom and 18 healthy subjects (11 female; ages 28 ± 8 years).

Field strength and sequences: MRF, modified Look-Locker inversion recovery (MOLLI), and T₂-prepared balanced steady state free precession (T₂-bSSFP) at 0.55T.

Assessment: MRF T₁ and T₂ maps were reconstructed using (1) a low-rank technique with sparse and locally low-rank regularization (SLLR-MRF) and (2) a deep image prior (DIP-MRF). Accuracy and precision of MRF and conventional sequences were evaluated in a phantom. In vivo performance of MRF was evaluated in the 18 healthy subjects, with 7 subjects also undergoing conventional mapping. Myocardial T₁ and T₂ values were compared among methods and image quality scored by three readers (2, 3, and 4 years of experience) on a 5-point scale.

Statistical tests: Linear regression, Bland-Altman, intraclass correlation coefficient, and one-way ANOVA with p < 0.05 considered significant.

Results: Mean measurements in the left ventricular septum were 671 ± 31 ms (MOLLI), 761 ± 147 ms (SLLR-MRF), and 686 ± 39 ms (DIP-MRF) for T₁, and 63.5 ± 5.7 ms (T₂-bSSFP), 47.5 ± 12.7 ms (SLLR-MRF), and 45.2 ± 4.5 ms (DIP-MRF) for T₂. Compared to conventional mapping, DIP-MRF exhibited significantly lower T₂ but no differences in T₁ (p > 0.99). Standard deviations within the myocardium were significantly lower with DIP-MRF compared to SLLR-MRF (39 vs. 147 ms for T₁ and 4.5 vs. 12.7 ms for T₂). Overall image quality ratings were significantly lower for SLLR-MRF (T₁: 2.3, T₂: 2.9), which were significantly lower compared to conventional mapping methods (T₁: 3.4, T₂: 3.9), and DIP-MRF (T₁: 3.8, T₂: 4.1) received higher scores.

Data conclusion: This study demonstrated the feasibility of cardiac MRF on a commercial 0.55T system, enabled by a deep image prior reconstruction for denoising.

Evidence level: 2.

Stage of technical efficacy: 1.

背景：0.55T系统具有独特的优势，可以支持扩大心脏MRI的使用范围。目的：评估0.55T心脏MR指纹识别（MRF）的可行性，利用深度图像先验重建来减轻噪声。研究类型：幻影和前瞻性体内评估。人群：ISMRM/NIST MRI系统幻影和18名健康受试者（11名女性，年龄28±8岁）。场强和序列：0.55T时的MRF、改进的Look-Locker反演恢复（MOLLI）和t2制备的平衡稳态自由进动（T2-bSSFP）。评估：MRF T1和T2地图重建使用(1)低秩稀疏和局部低秩正则化技术（SLLR-MRF）和(2)深度图像先验（DIP-MRF）。在假体中评估了磁共振成像和常规序列的准确性和精密度。在18名健康受试者中评估了磁共振成像的体内性能，其中7名受试者也进行了常规制图。心肌T1和T2值比较方法和图像质量评分的三个读者（2,3和4年的经验）在5分制。统计学检验：线性回归、Bland-Altman、类内相关系数、单因素方差分析p结果：T1左室间隔平均测量值为671±31 ms （MOLLI）、761±147 ms （SLLR-MRF）、686±39 ms (DIP-MRF)； T2左室间隔平均测量值为63.5±5.7 ms （T2- bssfp）、47.5±12.7 ms （SLLR-MRF）、45.2±4.5 ms （DIP-MRF）。与常规定位相比，DIP-MRF显示T2明显降低，但T1无差异（p < 0.99）。与SLLR-MRF相比，DIP-MRF在心肌内的标准差显著降低（T1为39 vs 147 ms， T2为4.5 vs 12.7 ms）。SLLR-MRF的整体图像质量评分（T1: 2.3, T2: 2.9）明显低于常规制图方法（T1: 3.4, T2: 3.9）， DIP-MRF （T1: 3.8, T2: 4.1）得分较高。数据结论：本研究证明了心脏MRF在商用0.55T系统上的可行性，该系统通过深度图像先验重建进行去噪。证据等级：2。技术功效阶段：

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引用次数: 0

Multisequence MRI Enables High-Fidelity FDG-PET Synthesis for Epilepsy Using GANs. 多序列MRI利用gan实现高保真癫痫FDG-PET合成。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-16 DOI: 10.1002/jmri.70231

Chenyang Yao, Bixiao Cui, Jingjuan Wang, Zhen-Ming Wang, Chunxue Wu, Yi Shan, Hongwei Yang, Jie Lu

Background: FDG-PET aids presurgical epilepsy evaluation but is limited by access and radiation exposure.

Purpose: To evaluate synthetic FDG-PET generated from T1-weighted imaging and resting-state fMRI metrics.

Study type: Retrospective.

Population: 481 participants underwent simultaneous FDG PET/MR. Internal cohort: 311 epilepsy patients split into training/validation/internal test sets (n = 249/31/31; age 18.79 ± 16.33/22.20 ± 11.21/21.65 ± 17.62 years; male/female 145/104, 13/18, 22/9). External cohort: 115 temporal lobe epilepsy patients (age 25.36 ± 10.95 years; male/female 68/47) and 55 healthy controls (age 27.62 ± 5.82 years; male/female 24/31); 92 had surgery with 1-year outcome.

Field strength: Hybrid PET/MR at 3.0 T; gradient-echo T1WI, echo-planar imaging and resting-state BOLD gradient-echo EPI.

Assessment: Performance was assessed using SSIM, PSNR, MSE, NRMSE, SUVR correlation, and Bland-Altman analysis. Three blinded readers performed visual quality grading and detection of temporal lobe hypometabolism. Hippocampal radiomics was used for classification of hippocampal sclerosis and Engel outcome.

Statistical tests: t-tests, chi-square tests, Pearson correlation, Kolmogorov-Smirnov tests, DeLong tests, and false discovery rate correction.

Results: Excellent/Good visual ratings occurred in 82.8% (166/201), with Fleiss' κ = 0.42. SSIM was 0.98 ± 0.01 (internal) and 0.97 ± 0.01 (external); PSNR was 66.66 ± 1.25 and 64.16 ± 1.83, respectively. SUVR correlation with ground-truth PET was r = 0.94 (internal) and r = 0.89 (external); Bland-Altman bias was -0.02 (95% limits of agreement: -0.22 to 0.18) internally and -0.00002 (95% limits: -0.35 to 0.35) externally. Detection accuracy for temporal hypometabolism was 90.3% (internal; κ = 0.735) and 87.1% (external; κ = 0.758). Radiomics AUCs using synthetic PET were 0.72 (95% CI: 0.62-0.83) for hippocampal sclerosis versus healthy controls and 0.77 (95% CI: 0.67-0.87) for Engel IA versus IB-IV; DeLong tests versus ground-truth PET were non-significant (p = 0.56 and p = 0.48).

Conclusion: Multisequence MRI-based synthetic PET showed high agreement with ground-truth PET across image-quality and quantitative SUVR metrics, providing a PET-like metabolic surrogate when FDG-PET is unavailable or impractical.

Level of evidence: Evidence Level 3.

Stages of technical efficacy: Stage 3.

背景：FDG-PET有助于术前癫痫评估，但受访问和辐射暴露的限制。目的：评价由t1加权成像和静息状态fMRI指标生成的合成FDG-PET。研究类型：回顾性。人群：481名参与者同时接受了FDG PET/MR检查。内部队列：311例癫痫患者分为训练组/验证组/内部测试组（n = 249/31/31，年龄18.79±16.33/22.20±11.21/21.65±17.62岁，男/女145/104、13/18、22/9）。外部队列：115例颞叶癫痫患者（年龄25.36±10.95岁，男/女68/47）和55例健康对照（年龄27.62±5.82岁，男/女24/31）；92例接受手术治疗，预后1年。场强：混合PET/MR 3.0 T；梯度-回波T1WI、回波平面成像和静息状态BOLD梯度-回波EPI。评估：采用SSIM、PSNR、MSE、NRMSE、SUVR相关性和Bland-Altman分析对绩效进行评估。三名盲法读者进行了视觉质量分级和颞叶代谢低下的检测。海马放射组学用于海马硬化和Engel预后的分类。统计检验：t检验、卡方检验、Pearson相关性、Kolmogorov-Smirnov检验、DeLong检验和错误发现率校正。结果：视觉评分为优/良的占82.8% (166/201),Fleiss’κ = 0.42。SSIM分别为0.98±0.01（内）和0.97±0.01（外）；PSNR分别为66.66±1.25和64.16±1.83。SUVR与PET的相关性分别为r = 0.94（内部）和r = 0.89（外部）；Bland-Altman偏倚内部为-0.02(95%一致性限：-0.22至0.18)，外部为-0.00002（95%一致性限：-0.35至0.35）。时间代谢低下的检测准确率为90.3%（内部；κ = 0.735）和87.1%（外部；κ = 0.758）。使用合成PET的放射组学auc在海马硬化症与健康对照中为0.72 (95% CI: 0.62-0.83)，在Engel IA与IB-IV组中为0.77 (95% CI: 0.67-0.87)；DeLong检验与ground-truth PET比较无显著性（p = 0.56和p = 0.48）。结论：基于多序列mri的合成PET在图像质量和定量SUVR指标上与真实PET高度一致，在FDG-PET不可用或不切实际时提供了类似PET的代谢替代品。证据等级：证据等级3。技术功效阶段：第三阶段。

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引用次数: 0

Editorial for "Multisequence MRI Enables High-Fidelity FDG-PET Synthesis for Epilepsy Using GANs". 社论“多序列MRI使高保真FDG-PET合成癫痫使用gan”。

IF 3.5 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Magnetic Resonance Imaging

Pub Date : 2026-01-16 DOI: 10.1002/jmri.70234

Min-Ying Lydia Su

引用次数: 0