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A Review on Frailty in Patient with Liver Cirrhosis and Its Management 肝硬化患者虚弱及其处理综述
Pub Date : 2020-01-01 DOI: 10.35248/2167-0889.20.9.240
S. Thasneem, Yedu Krishnan Ss, Roshni Pr, S. Sadasivan
Frailty is an unstable phenomenon affecting multiple physiological systems, resulting in decreased reserve and vulnerable outcomes. With ageing the prevalence of frailty seems to be increasing general population as well as with cirrhosis patients. Though research are undergoing on prognostic markers, gut microbes or pharmacology in hepatology, it should be extended to a proper definition for frailty its diagnostic tool and management. Frailty score should be considered along with MELD score as a routine assessment in patients waiting for liver transplantation. Malnutrition is a common complication of cirrhosis patients which may leads to frailty, even though frailty is seen in well-nourished patients. When normal dietary supplements become ineffective the need for nutritional supplements like Branched chain amino acids (BCAA) become necessary. Combining BCAAs along with exercise therapy have shown significant improvements for lower limb muscle strength and balance ability in frail and pre-frail cirrhotic patients since muscle wasting is a major concern for them.
脆弱是一种影响多个生理系统的不稳定现象,导致储备减少和脆弱结局。随着年龄的增长,虚弱的患病率似乎在增加,一般人群以及肝硬化患者也是如此。虽然研究正在进行预后标志物,肠道微生物或药理学肝病学,它应该扩展到一个适当的定义,虚弱的诊断工具和管理。衰弱评分应与MELD评分一起作为等待肝移植患者的常规评估。营养不良是肝硬化患者的常见并发症,可能导致虚弱,即使在营养良好的患者中也会出现虚弱。当正常的膳食补充剂变得无效时,就需要像支链氨基酸(BCAA)这样的营养补充剂。由于肌肉萎缩是虚弱和虚弱前肝硬化患者的主要问题,将支链氨基酸与运动疗法相结合已显示出对虚弱和虚弱前肝硬化患者下肢肌肉力量和平衡能力的显著改善。
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引用次数: 1
Recent and Novel Observations Pertaining to Non-Infectious Liver Disorders 关于非传染性肝脏疾病的最新和新的观察
Pub Date : 2020-01-01 DOI: 10.35248/2167-0889.20.9.E118
Min Li
Clinical hepatology has recently gained a wider recognition among medical community owing to the advancements in liver biochemical investigations and with liver diseases now being increasingly recognized as a major threat to public health. Malnutrition, drug addiction, alcohol abuse and environmental pollution are prevalent across different regions of the world which are identified to be associated with risk factors of liver diseases. Liver diseases, if highly prevalent and if remain untreated, may lead to reduced longevity and productivity and can hamper the socioeconomic contribution.
近年来,由于肝脏生化研究的进步和肝脏疾病日益被认为是公共卫生的主要威胁,临床肝病学在医学界得到了更广泛的认可。营养不良、吸毒成瘾、酗酒和环境污染在世界不同区域普遍存在,这些已被确定为与肝脏疾病的危险因素有关。肝病如果高度流行且得不到治疗,可能导致寿命缩短和生产力下降,并可能妨碍社会经济贡献。
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引用次数: 0
Editor's Note on Liver Journal 肝脏杂志编者注
Pub Date : 2020-01-01 DOI: 10.35248/2167-0889.20.9.E119
Min Li
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引用次数: 0
Liver Fibrosis Conventional and Molecular Imaging Diagnosis Update 肝纤维化常规和分子影像学诊断进展
Pub Date : 2019-01-22 DOI: 10.35248/2167-0889.19.8.236
Shujing Li, Xicui Sun, Minjie Chen, Z. Ying, Yamin Wan, Liya Pi, Bin Ren, Qi Cao
Liver fibrosis is a serious, life-threatening disease with high morbidity and mortality that result from diverse causes. Liver biopsy, considered the “gold standard” to diagnose, grade, and stage liver fibrosis, has limitations in terms of invasiveness, cost, sampling variability, inter-observer variability, and the dynamic process of fibrosis. Compelling evidence has demonstrated that all stages of fibrosis are reversible if the injury is removed. There is a clear need for safe, effective, and reliable non-invasive assessment modalities to determine liver fibrosis in order to manage it precisely in personalized medicine. However, conventional imaging methods used to assess morphological and structural changes related to liver fibrosis, including ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI), are only useful in assessing advanced liver disease, including cirrhosis. Functional imaging techniques, including MR elastography (MRE), US elastography, and CT perfusion are useful for assessing moderate to advanced liver fibrosis. MRE is considered the most accurate noninvasive imaging technique, and US elastography is currently the most widely used noninvasive means. However, these modalities are less accurate in early-stage liver fibrosis and some factors affect the accuracy of these techniques. Molecular imaging is a target-specific imaging mechanism that has the potential to accurately diagnose early-stage liver fibrosis. We provide an overview of recent advances in molecular imaging for the diagnosis and staging of liver fibrosis which will enable clinicians to monitor the progression of disease and potentially reverse liver fibrosis. We compare the promising technologies with conventional and functional imaging and assess the utility of molecular imaging in precision and personalized clinical medicine in the early stages of liver fibrosis.
肝纤维化是一种严重的、危及生命的疾病,由多种原因引起,发病率和死亡率高。肝活检被认为是肝纤维化诊断、分级和分期的“金标准”,但在侵入性、成本、采样可变性、观察者间可变性和纤维化动态过程等方面存在局限性。令人信服的证据表明,如果损伤被切除,所有阶段的纤维化都是可逆的。显然需要安全、有效、可靠的非侵入性评估方式来确定肝纤维化,以便在个性化医疗中精确管理肝纤维化。然而,用于评估与肝纤维化相关的形态学和结构变化的传统成像方法,包括超声、计算机断层扫描(CT)和磁共振成像(MRI),仅适用于评估晚期肝病,包括肝硬化。功能成像技术,包括磁共振弹性成像(MRE)、超声弹性成像和CT灌注,可用于评估中度至晚期肝纤维化。MRE被认为是最精确的无创成像技术,而US弹性成像是目前应用最广泛的无创成像手段。然而,这些方法在早期肝纤维化中准确性较低,并且一些因素会影响这些技术的准确性。分子成像是一种靶向特异性成像机制,具有准确诊断早期肝纤维化的潜力。我们概述了肝纤维化的分子成像诊断和分期的最新进展,这将使临床医生能够监测疾病的进展并有可能逆转肝纤维化。我们将这些有前景的技术与常规和功能成像技术进行比较,并评估分子成像技术在肝纤维化早期精确和个性化临床医学中的应用。
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引用次数: 20
Aeromonas Infections in Patients with Liver Cirrhosis in Japan 日本肝硬化患者的气单胞菌感染
Pub Date : 2019-01-01 DOI: 10.4172/2167-0889.1000235
T. Shizuma
Aeromonas species are recognized as opportunistic pathogens that cause serious problems in patients with liver cirrhosis (LC). In this article, 25 case reports of Aeromonas infections in patients with LC in Japan are reviewed and summarized. Among the 25 cases, cases of septicemia or skin and soft tissue infections have been relatively well reported. In total, the 1-month mortality rate was 68% (17/25), whereas the overall survival rate was 32% (8/25). In particular, among 16 cases with skin and soft tissue infections, 12 (75%) died within the first 4 days after admission, regardless of the administration of antimicrobial agents and/or lower limb amputation, indicating extremely poor short-term prognosis.
气单胞菌被认为是导致肝硬化(LC)患者严重问题的机会性病原体。本文对日本25例LC患者气单胞菌感染病例进行了回顾和总结。在25例病例中,败血症或皮肤软组织感染的病例报道较多。1个月总死亡率为68%(17/25),总生存率为32%(8/25)。特别是,在16例皮肤和软组织感染病例中,12例(75%)在入院后4天内死亡,无论是否给予抗菌药物和/或截肢,表明短期预后极差。
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引用次数: 0
Spontaneous Fungal Peritonitis in Patients with Liver Cirrhosis 肝硬化患者自发性真菌性腹膜炎
Pub Date : 2019-01-01 DOI: 10.35248/2167-0889.19.8.238
T. Shizuma
Although spontaneous peritonitis is a common infection in liver cirrhosis patients, little is known about the clinical characteristics and treatments of spontaneous fungal peritonitis (SFP) or fungiascites. Although diagnosis of SFP or fungiascites is made according to the cell counts and culture in ascitic fluid, delayed diagnosis has been associated with poor prognosis of SFP. Risk factors for SFP include severe underlying liver dysfunction, hospitalization and nosocomial infections. SFP mortality rates have been estimated as higher than those of spontaneous bacterial peritonitis. Although early administration of appropriate antifungal agents may be necessary, it remains uncertain whether antifungal therapies would decrease SFP’s mortality rate.
自发性腹膜炎是肝硬化患者常见的一种感染,但对自发性真菌性腹膜炎(SFP)或真菌性腹水的临床特点及治疗方法了解甚少。虽然根据腹水中的细胞计数和培养来诊断SFP或真菌腹水,但延迟诊断与SFP的预后不良有关。SFP的危险因素包括严重的潜在肝功能障碍、住院和医院感染。据估计,SFP的死亡率高于自发性细菌性腹膜炎。虽然早期给予适当的抗真菌药物可能是必要的,但抗真菌治疗是否会降低SFP的死亡率仍不确定。
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引用次数: 0
Importance of Prolidase Enzyme Activity and Serum Cytokeratin 18 Levels for Differential Diagnosis between Asymptomatic Hepatitis B Carriers and HBeAg Negative Chronic Hepatitis B Patients 增殖酶活性和血清细胞角蛋白18水平对无症状乙型肝炎携带者和HBeAg阴性慢性乙型肝炎患者鉴别诊断的重要性
Pub Date : 2019-01-01 DOI: 10.35248/2167-0889.19.8.237
N. Yılmaz, A. Balkan, M. Koruk
Background: In this study, it was aimed to evaluate the relationship between the severity of necroinflammation in the liver and the stage of fibrosis and the serum levels of Serum Prolidase Activity (SPA) and Cytokeratin (CK)-18 in patients with active Chronic Hepatitis B (CHB) and asymptomatic Hepatitis B Virus (HBV) carriers. Methods: Biochemical analyses, serological parameters associated with HBV and serum prolidase activity and CK-18 levels were measured in asymptomatic HBV carriers (n=65), active CHB patients (n=60) and healthy controls (n=27). Liver biopsies were performed on asymptomatic HBV carriers and active CHB patients. Findings: SPA level was significantly higher in active CHB patients (819.92 ± 123.74 IU/L) compared to asymptomatic HBV carriers (732.99 ± 124.70 IU/L) and was higher in asymptomatic HBV carriers compared to healthy controls (529.4 ± 74.73 IU/L) (p=0.001). The diagnostic cut-off value of SPA level was found 751.15 U/L. When this cut-off value was taken to differentiate HBe-Ag negative CHB in asymptomatic HBV carriers, sensitivity and specificity of efficacy were 72% and 63% respectively (c-statistics: 0.707). A strong positive correlation was observed between serum prolidase level and the severity of fibrosis in asymptomatic HBV carriers (r=0.603, p=0.000). A positive correlation was determined between SPA level and Histological Activity Index (HAI) scores in patients with active CHB and asymptomatic HBV carriers. The serum CK-18 levels were significantly lower in the healthy control group when compared to the asymptomatic HBV carriers and active CHB patients (p=0.001). Conclusion: Prolidase enzyme may be beneficial in differentiating asymptomatic HBV carriers from HBeAg-negative CHB patients when used in combination with ALT and HBV-DNA levels.
背景:本研究旨在评价活动性慢性乙型肝炎(CHB)和无症状乙型肝炎病毒(HBV)携带者的肝脏坏死性炎症严重程度和纤维化分期与血清增殖酶活性(SPA)和细胞角蛋白(CK)-18水平的关系。方法:对无症状HBV携带者(n=65)、活动性CHB患者(n=60)和健康对照(n=27)进行生化分析、血清HBV相关血清学指标及血清蛋白酶活性和CK-18水平测定。对无症状HBV携带者和活动性CHB患者进行肝活检。结果:活动性CHB患者的SPA水平(819.92±123.74 IU/L)明显高于无症状HBV携带者(732.99±124.70 IU/L),无症状HBV携带者的SPA水平明显高于健康对照组(529.4±74.73 IU/L) (p=0.001)。SPA水平的诊断临界值为751.15 U/L。当采用该临界值区分无症状HBV携带者中HBe-Ag阴性CHB时,疗效的敏感性和特异性分别为72%和63% (c-statistics: 0.707)。无症状乙肝病毒携带者血清增殖酶水平与纤维化严重程度呈正相关(r=0.603, p=0.000)。在活动性CHB患者和无症状HBV携带者中,SPA水平与组织学活动指数(HAI)评分呈正相关。与无症状HBV携带者和活动性CHB患者相比,健康对照组血清CK-18水平显著降低(p=0.001)。结论:当与ALT和HBV- dna水平联合使用时,增殖酶可能有助于区分无症状HBV携带者和hbeag阴性CHB患者。
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引用次数: 0
Effect of Static Magnetic Fields on Proliferation and Apoptosis of Gallbladder Cancer Cells: An in vitro and in vivo study 静磁场对胆囊癌细胞增殖和凋亡的影响:体外和体内研究
Pub Date : 2018-03-02 DOI: 10.4172/2167-0889.1000227
Huanle Yang, J. Xiang, Jian Dong, Jiwen Cheng, Xinglong Zheng, Peng Liu, Rongqian Wu, Y. Lv
Objectives: The knowledge on how static magnetic fields (SMF) of magnetic implants affect living cells and tissues is limited while these magnetic devices are more and more frequently adopted in certain surgical approaches. Methods: In this study, we exposed cultures of human gallbladder cancer cells to SMF continuously for up to 7 days, trying to simulate the exposure pattern of surgical magnetic implants, and implanted magnetic devices into tumor-bearing nude mice for 1 month, then evaluated the effect on proliferation and apoptosis of cancer cells and tissues. Results: It showed that after SMF exposure, whereas in vitro study showed decreased cell proliferation and increased apoptosis of the gallbladder cancer cells, in vivo study showed no significant differences both on proliferation and on apoptosis. Conclusions: Our findings indicate that with current magnetic biliary anastomosis devices, the SMF from magnetic implants shows little effects on proliferative and apoptotic activities of gallbladder cancer cells in vivo, while there are still possibilities that long-term continuous SMF exposure from surgical magnetic implants may interact with living cells, probably in a feeble manner.
目的:磁性植入物的静磁场(SMF)如何影响活细胞和组织的知识有限,而这些磁性植入物越来越多地用于某些手术入路。方法:在本研究中,我们将人胆囊癌细胞培养物连续暴露于SMF长达7天,试图模拟外科磁性植入物的暴露模式,并将磁性装置植入荷瘤裸鼠体内1个月,观察其对癌细胞和组织增殖和凋亡的影响。结果:SMF暴露后,体外研究显示胆囊癌细胞增殖减少,凋亡增加,而体内研究显示胆囊癌细胞增殖和凋亡均无显著差异。结论:我们的研究结果表明,在现有的磁性胆道吻合术中,磁性植入物的SMF对胆囊癌细胞的增殖和凋亡活性的影响很小,而手术磁性植入物长期持续暴露的SMF仍有可能与活细胞相互作用,可能是微弱的相互作用。
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引用次数: 1
Portal Vein Thrombosis with Tropical Splenomegaly-A Rare Coincidental Finding 门静脉血栓形成伴热带脾肿大-罕见的巧合发现
Pub Date : 2018-01-05 DOI: 10.4172/2167-0889.1000225
N. Gupta, M. Wadhawan, Varun Gupta
Tropical splenomegaly syndrome has rarely been associated as a cause of portal hypertension in patients living in endemic malarial zone. TSS has however has never been reported to be associated with portal vein thrombosis. We report a case of a 17 year old male who presented with features of portal hypertension and on radiological evaluation was found to have portal vein thrombus with cavernoma formation. Liver biopsy was performed for ruling out other pathologies and cirrhosis and was found to have hemozoin pigment along with features of inflow vascular pathology. We here in report first case of tropical splenomegaly with portal vein thrombosis.
热带脾肿大综合征很少被认为是疟疾流行区患者门静脉高压症的原因。然而,从未有报道称TSS与门静脉血栓形成有关。我们报告一个17岁男性的病例,他表现出门静脉高压的特征,在放射学评估中发现有门静脉血栓伴海绵瘤形成。为排除其他病理及肝硬化,行肝活检,发现血色素伴流入血管病理特征。我们在此报告首例热带脾肿大合并门静脉血栓的病例。
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引用次数: 0
Epidemiologic Study on the Incidence of Biliary Complications after Liver Transplantation 肝移植术后胆道并发症发生率的流行病学研究
Pub Date : 2018-01-01 DOI: 10.4172/2167-0889.1000229
Ana Cláudia de Souza Silva, A. Andrade, Quelson Coelho Lisboa, C. X. Lima, J. Araújo, Thaís Gambogi, V. Borges, I. Filho
Ana Claudia De Souza Silva1, Antônio Márcio De Faria Andrade1, Quelson Coelho Lisboa1, Cristiano Xavier de Lima1, Juliana Papatella Araújo1, Thaís Ribeiro Gambogi1, Valdineria Oliveira Borges1 and Idiberto José Zotarelli Filho2* 1Department of gastroenterology, Hepatology and Liver Transplantation Felício Rocho Hospital, Belo Horizonte, MG, Brazil 2Post Graduate and Continuing Education (Unipos), Department of Scientific Production, Street Ipiranga, 3460, São José do Rio Preto SP, Brazil
Ana Claudia De Souza silva a1, Antônio Márcio De Faria Andrade1, Quelson Coelho Lisboa1, Cristiano Xavier De Lima1, Juliana Papatella Araújo1, Thaís Ribeiro Gambogi1, Valdineria Oliveira Borges1和Idiberto jos Zotarelli Filho2* 1巴西贝洛奥里藏特罗乔医院消化内科、肝脏内科和肝脏移植科Felício巴西罗乔医院2研究生和继续教育(Unipos),科学生产部,Street Ipiranga, 3460, o jos do Rio Preto SP,巴西
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引用次数: 1
期刊
Journal of Liver
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