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Possible role of estrogen receptors in gender susceptibility in the development of chronic infections and liver cancers 雌激素受体在慢性感染和肝癌发展中性别易感性的可能作用
Pub Date : 2016-11-08 DOI: 10.4172/2167-0889.C1.007
A. Kaul
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引用次数: 0
The Histological Assessment of Hepatitis B Viral Activity in Patients with Heavy Alcohol Consumption 重度饮酒患者乙型肝炎病毒活性的组织学评估
Pub Date : 2016-11-04 DOI: 10.4172/2167-0889.1000204
Chih‐Wen Lin, Chia-Chang Hsu, D. Perng, M. Yeh, Sien‐Sing Yang
Objectives: Taiwan has a high prevalence of hepatitis B viral (HBV) infection with rising alcoholic liver disease. We investigated the histological assessment of viral hepatitis B activity in patients with concomitant HBV infection and alcoholism. Methods: 229 patients (33 with concomitant heavy alcoholism and HBV infection, 114 with HBV infection alone, and 82 with heavy alcoholism alone) were enrolled between 2009 and 2012 at Cathy General hospital and E-Da hospital. Results: Patients with concomitant alcoholism and HBV infection are male predominant and younger. 97.4% and 91.4% patients have detectable HBV DNA in patients with HBV infection without or with alcoholism, respectively. Patients with concomitant HBV infection and alcoholism have much piecemeal necrosis, confluent necrosis, focal necrosis, portal inflammation, necroinflammatory grading, and cirrhosis with Ishak stage 5-6 fibrosis. Moreover, patients with concomitant HBV infection and alcoholism also have much pericelluar fibrosis, sclerosing hyaline necrosis, non-alcoholic fatty liver disease (NAFLD) ballooning, NAFLD activity score (NAS) and NAFLD Stage 4 fibrosis (P<0.001). However, patients with alcoholism alone have much more steatosis than those with HBV infection with and without alcoholism. Conclusions: Patients having concomitant alcoholism and HBV infection develop the histological features of both alcoholic liver disease and viral hepatitis B. The assessment of hepatitis B viral activity in alcoholic liver disease depends on detectable viral load and histological features of viral hepatitis B in patients with concomitant HBV infection and alcoholism.
目的:台湾乙型肝炎病毒(HBV)感染率高,酒精性肝病呈上升趋势。我们研究了伴有HBV感染和酒精中毒的患者的乙型病毒性肝炎活性的组织学评估。方法:2009 - 2012年在Cathy总医院和E-Da医院收集229例患者,其中重度酒精中毒合并HBV感染33例,单纯HBV感染114例,单纯重度酒精中毒82例。结果:伴有酒精中毒和HBV感染的患者以男性为主,年轻化。97.4%和91.4%的HBV感染和酒精中毒患者检测到HBV DNA。伴有HBV感染和酒精中毒的患者有许多碎片性坏死、融合性坏死、局灶性坏死、门脉炎、坏死性炎症分级和伴有Ishak 5-6期纤维化的肝硬化。此外,合并HBV感染和酒精中毒的患者也有较多的细胞周围纤维化、硬化性透明坏死、非酒精性脂肪性肝病(NAFLD)球囊化、NAFLD活动评分(NAS)和NAFLD 4期纤维化(P<0.001)。然而,酒精中毒的患者比HBV感染伴或不伴酒精中毒的患者有更多的脂肪变性。结论:酒精中毒和HBV合并感染的患者具有酒精性肝病和病毒性肝炎的组织学特征。评估酒精性肝病患者的乙型肝炎病毒活性取决于HBV合并感染和酒精中毒患者可检测到的病毒载量和病毒性肝炎的组织学特征。
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引用次数: 2
Acute B Hepatitis after Hepatitis C Virus Therapy with Direct Acting Antivirals in a Co-infected Patient with HIV 直接抗病毒药物治疗丙型肝炎合并HIV感染患者后急性乙型肝炎
Pub Date : 2016-11-01 DOI: 10.4172/2167-0889.1000203
María García, I. Hernández, F. Cuenca, Maria Villegas
Up until now, few cases of HBV reactivation after HCV therapy with new direct acting antivirals have been communicated, the majority of them without clinical repercussion. We present a case of fulminant hepatic failure for HBV reactivation in a patient infected with human immunodeficiency virus, after HCV therapy with DAAs.
到目前为止,使用新的直接作用抗病毒药物治疗HCV后HBV再激活的病例很少,其中大多数没有临床反应。我们报告了一例感染人类免疫缺陷病毒的患者,在用DAAs治疗HCV后,因HBV再激活而暴发性肝衰竭。
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引用次数: 1
Hepatic Functions and its Disorders 肝功能及其紊乱
Pub Date : 2016-10-31 DOI: 10.4172/2167-0889.1000E111
Xia Xuefeng, J. Park
Xia Xuefeng1* and Jun Yong Park2 1Principal Investigator, Center for Diabetes Research, The Methodist Hospital Research Institute, Houston, Texas, USA 2Department of Internal Medicine, Yonsei University College of Medicine, Korea *Corresponding author: Principal Investigator, Center for Diabetes Research, The Methodist Hospital Research Institute, Houston, Texas, USA, Tel: 713-441-6665; Email: xuefengx@gmail.com
夏雪峰1*、parkjun Yong 2 1美国德克萨斯州休斯顿卫理公会医院研究所糖尿病研究中心首席研究员2韩国延世大学医学院内科*通讯作者:美国德克萨斯州休斯顿卫理公会医院研究所糖尿病研究中心首席研究员,电话:713-441-6665;电子邮件:xuefengx@gmail.com
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引用次数: 0
Global Analysis of Proteomics for Discovery of Biomarkers in Hepatocellular Carcinoma 蛋白质组学在肝细胞癌生物标志物发现中的全局分析
Pub Date : 2016-10-27 DOI: 10.4172/2167-0889.1000202
Hong Li, Jiangbei Yuan, Fangbing Zhai, Jianqiang Zhang, Hua He, Xuefeng Xia
Hepatocellular Carcinoma (HCC) is a most lethal malignancy. At first presentation, patients often already have advanced disease, and their treatment options for cure are very limited. Measurable biomarkers for early diagnosis of HCC are urgently needed to prolong the median over-all survival rate and reduce therapeutic expenditures. Proteomics is a powerful analytical technique that has been widely applied to search for cancer biomarkers, including in HCC. High-sensitivity, high-throughput, and non-invasive technologies should be capable of contributing to early diagnosis of HCC. In this review, we provide a flow scheme for proteomic study in HCC, and an overview of technical approaches for protein quantification. In addition, we present a broad summary of the HCC biomarkers proposed by studies in recent years, which have used various quantitative proteomic approaches.
肝细胞癌(HCC)是一种最致命的恶性肿瘤。初次就诊时,患者往往已经处于疾病晚期,他们的治疗选择非常有限。迫切需要可测量的HCC早期诊断生物标志物,以延长中位总生存率并减少治疗费用。蛋白质组学是一种强大的分析技术,已广泛应用于寻找癌症生物标志物,包括HCC。高灵敏度、高通量和非侵入性技术应该能够有助于HCC的早期诊断。在这篇综述中,我们提供了HCC蛋白质组学研究的流程方案,并概述了蛋白质定量的技术方法。此外,我们对近年来使用各种定量蛋白质组学方法的研究提出的HCC生物标志物进行了广泛的总结。
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引用次数: 1
Comparative Effects of Scorpion Venom and Aqueous Basil ( Ocimum basilicum ) Leaves Extracts on Ccl4-induced Toxicity in Albino Rats 天蝎毒液与罗勒叶水提取物对ccl4致白化大鼠毒性的比较研究
Pub Date : 2016-09-27 DOI: 10.4172/2167-0889.1000201
Muhammad Salman, N. Kasem, N. Saleh
The present study aims to compare the therapeutic effects between to extract scorpion venom (bradykinin potentiating factor; BPF) and aqueous extract of Sweet basil (Ocimum basilicum) on CCl4-induced toxicity of liver and kidney in albino rats. Rats were divided into 8 groups. Group (1) was served as normal group; Group (2) was injected intraperitoneal (i.p.) once a week for 3 weeks with BPF at a dose (1 μgm/g). Group (3) was received orally O. basilicum extract, twice a week for 6 weeks at dose (20 ml/kg). Group 4 was treated with the same doses of BPF and O. basilicum. Group (5) was injected i.p. with CCl4 (1 ml/kg), 3 times weekly, for 2 weeks and served as control group. Groups 6, 7 and 8 were injected i.p. with CCl4 then treated i.p. with BPF, orally with O. basilicum and BPF plus O. basilicum respectively. The results of the present study cleared that normal group (1) and groups (2, 3 and 4) showed no significant difference in all liver and kidney functions, besides antioxidant enzymes except creatinine and GSH, were highly significant increase in group (4). CCl4 caused a highly significant decrease in serum albumin, uric acid, besides Catalase, GSH, SOD activities in liver tissue, while there are an elevation in serum AST, ALT, ALP, γ-GT, creatinine and Urea, besides MDA and NO levels in liver tissue. While, groups (6, 7 and 8) revealed reverse effect in all parameters and recorded a remarkable improvement, comparing with normal group. It can be concluded that the treatment with the extract from the scorpion venom Buthus occitanus (BPF) is more effective than those of extract from the plant (O. basilicum) against the toxicity of liver and kidney-induced by CCl4 in albino rats. In addition, the hepato-ameliorating and antioxidant effects of two extracts were found to be better than those of extract of BPF or O. basilicum indepently.
本研究旨在比较蝎毒缓激肽增强因子;甜罗勒(Ocimum basilicum)水提物对ccl4诱导的白化大鼠肝、肾毒性的影响。大鼠分为8组。1组为正常组;组(2)每周1次腹腔注射BPF,剂量为1 μgm/g,连用3周。3组患者口服罗勒提取物,每周2次,剂量为20 ml/kg,连用6周。第4组用相同剂量的BPF和basilicum处理。组(5)ig注射CCl4 (1 ml/kg),每周3次,连用2周,作为对照组。第6组、第7组和第8组分别腹腔注射CCl4,然后腹腔注射BPF、口服罗勒及BPF加罗勒。本研究结果表明,正常组(1)和各组(2、3、4)肝肾功能均无显著差异,除抗氧化酶肌酐和谷胱甘肽外,各组(4)除抗氧化酶肌酐和谷胱甘肽外,均显著升高。CCl4使血清白蛋白、尿酸、过氧化氢酶、谷胱甘肽、肝组织SOD活性显著降低,血清AST、ALT、ALP、γ-GT、肌酐和尿素升高。肝组织中MDA和NO的含量而组(6、7、8)各项指标均出现逆转,较正常组有显著改善。由此可见,蝎毒Buthus occitanus (BPF)提取物对CCl4诱导的白化大鼠肝肾毒性的治疗效果优于该植物提取物。此外,两种提取物的肝脏改善和抗氧化作用均优于单独提取的BPF或basilicum。
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引用次数: 2
Patho-physiological studies on the Reverse Effect of Curcumin (Curcuma longa, Zingiberaceae) and Ursofalk (Ursodeoxycholic acid) against the Toxicity of Carbon Tetrachloride on Albino Rats 姜黄素(Curcuma longa,姜科)和熊去氧胆酸(Ursodeoxycholic acid)对四氯化碳对白化大鼠毒性逆转作用的病理生理研究
Pub Date : 2016-08-19 DOI: 10.4172/2167-0889.1000200
Muhammad Salman, Abdel-rahman
This study, was established five groups of albino rats to determine the therapeutic effect of Curcuma longa and ursofalk against the toxicity of CC14 in liver and kidney. Group (1) was received orally NaCl 0.9% and used as a normal group. Group (2) was injected intraperitoneal (i.p.) with CCl4 (1 ml/kg), 3 times weekly, for 2 weeks. Group (3) was given orally Ursofalk (100 mg/kg per body weight), group (4) was given orally Curcuma longa (100 mg/kg body weight) and group (5) was given the same doses of Ursofalk plus Curcuma longa for 30 days respectively, post-injected intraperitoneal (i.p.) with CCl4 (1 ml/kg) 3 times weekly, for 2 weeks. Two blood samples were collected, for hematological and biochemical parameters. Specimens from liver and kidney were collected for histopathological examination. Group (2) revealed a highly significant decrease in total RBCs, platelets, Hb and PCV, serum uric acid, albumin, glucose, HDL-cholesterol, besides catalase, GSH, SOD activities in liver tissue, while WBCs, serum ALT, AST, ALP, γ-GT, creatinine, urea, cholesterol, triglycerides and LDL-cholesterol levels, besides Malondialdehyde and Nitric Oxide levels in liver tissue showed a highly significant increase. Meanwhile, groups (3, 4 and 5) displayed reverse effect in all parameters and return to normal. The histological results displayed inflammation with necrosis and degenerative changes in group (2), while remain groups showed mild changes particularly in group (5). It could be concluded that CCl4 induced destruction in liver and kidney, which showed a clear improvement by using of Ursofalk and Curcuma longa as treatment.
本实验建立5组白化大鼠,观察姜黄、乌尔索克对CC14肝、肾毒性的治疗作用。组(1)口服0.9% NaCl,作为正常组。组(2)腹腔注射CCl4 (1 ml/kg),每周3次,连用2周。组(3)口服Ursofalk (100 mg/kg /体重),组(4)口服姜黄(100 mg/kg体重),组(5)分别给予相同剂量的Ursofalk加姜黄,连续30天,每周3次,腹腔注射CCl4 (1 ml/kg),连续2周。采集两份血样,测定血液学和生化指标。取肝、肾标本进行组织病理学检查。(2)组小鼠总红细胞、血小板、Hb、PCV、血清尿酸、白蛋白、葡萄糖、hdl -胆固醇及肝组织过氧化氢酶、谷胱甘肽、SOD活性均显著降低;wbc、血清ALT、AST、ALP、γ-GT、肌酐、尿素、胆固醇、甘油三酯、ldl -胆固醇水平及肝组织丙二醛、一氧化氮水平均显著升高。同时,第3、4、5组各项参数均出现逆转,恢复正常。组织学结果显示(2)组炎症、坏死、退行性改变,其余各组变化较轻,尤其是(5)组。可见CCl4对肝脏和肾脏的破坏作用,经Ursofalk和姜黄治疗后明显改善。
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引用次数: 5
Watershed Hepatocellular Carcinoma â Utility of Cone Beam CT forTranscatheter Therapy and Case Report 流域肝癌ÃⅱÂÂ锥形束CT在经导管治疗中的应用及病例报告
Pub Date : 2016-08-10 DOI: 10.4172/2167-0889.1000198
S. McCabe, M. Lim, S. Maddineni, G. Rozenblit
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引用次数: 0
Relationship between the Status of Blood Supply in the Non-hypervascular Hepatocellular Nodules among Chronic Liver Diseases and the Hypervascular Change 慢性肝病非高血管性肝细胞结节血供状况与高血管性改变的关系
Pub Date : 2016-07-28 DOI: 10.4172/2167-0889.1000197
Junichi Taira, Y. Imai, Takatomo Sano, K. Sugimoto, Yoshihiro Furuichi, I. Nakamura, F. Moriyasu
Objectives: We observed the time-course changes of blood flow in non-hypervascular hepatocellular nodules that showed hypointensity in the hepatobiliary phase on Gd-EOB-DTPA-enhanced magnetic resonance imaging (EOB-MRI), and evaluated the relationship between hypervascular change and the status of blood supply in the nodules. Methods: The study included 69 hepatocellular nodules in 33 patients demonstrating hypointensity in the hepatobiliary phase on EOB-MRI and showing non-hypervascular features on CT during hepatic arteriography (CTHA) performed during the same period. Results: In relation to blood flow on CTHA/ CT during arterial portography (CTAP), the cumulative rate of hypervascular change at 52 weeks was 0.0% for iso/iso, 29.7% for hypo/iso, 61.5% for iso/hypo, and 55.0% for hypo/hypo. Multivariate analysis using COX proportional hazards regression showed that CTAP findings (hypodensity) and CTHA findings (hypo-density) were significant variables for hypervascular change. Conclusions: In cases of non-hypervascular hepatocellular tumors, nodules with decreased arterial or portal blood flow that show hypointensity in the hepatobiliary phase on EOB-MRI are likely to develop into typical hepatocellular carcinoma in a shorter time.
目的:观察gd - eob - dtpa增强磁共振成像(EOB-MRI)显示肝胆期低密度的非高血管性肝细胞结节血流的时间变化,并评价结节内高血管性改变与血供状况的关系。方法:本研究纳入33例患者的69个肝细胞结节,在同一时期进行肝动脉造影(CTHA)时,在EOB-MRI上表现为肝胆期低密度,而在CT上表现为非高血管特征。结果:相对于CTHA/ CT在动脉门静脉造影(CTAP)期间的血流,52周时,高血管改变的累积率iso/iso为0.0%,hypoo /iso为29.7%,iso/ hypo61.5%, hypoo / hypo55.0%。采用COX比例风险回归的多因素分析显示,CTAP检查结果(低密度)和CTHA检查结果(低密度)是高血管变化的显著变量。结论:在非高血管性肝细胞肿瘤中,动脉或门静脉血流减少的结节在EOB-MRI上表现为肝胆期低密度,可能在较短时间内发展为典型的肝细胞癌。
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引用次数: 8
Endoscopic Treatment for Anastomotic Varices after Choledochojejunostomy 胆总管空肠吻合术后吻合口静脉曲张的内镜治疗
Pub Date : 2016-07-07 DOI: 10.4172/2167-0889.1000I103
Takahiro Sato
Ectopic varices are defined as portosystemic venous collaterals occurring anywhere in the gastrointestinal tract other than the esophagogastric region. Anastomotic varices after choledochojejunostomy should be considered when evaluating gastrointestinal hemorrhage in patients with previous surgery and mesenteric venous hypertension. Hemorrhaging from varices in the jejunal loop [1], with extrahepatic portal vein obstruction after choledochojejunostomy, is a rare condition but several articles have been published. Various medical treatments, such as interventional radiology and surgery, have been used to control bleeding from anastomotic varices after choledochojejunostomy; however, there is no best treatment strategy for anastomotic varices. Anastomotic varices after choledochojejunostomy drain directly into the intrahepatic portal vein. Therefore, endoscopic treatment is difficult for this condition and endoscopic obliterative therapy with N-butyl-2-cyanoacrylate is the preferred treatment for this type varices [1,2].
异位静脉曲张被定义为发生在胃肠道的任何地方,而不是食管胃区。对既往手术及肠系膜静脉高压患者进行胃肠道出血评估时应考虑吻合口静脉曲张。空肠袢静脉曲张出血[1],胆肠吻合术后肝外门静脉阻塞是一种罕见的情况,但已有几篇文章发表。各种医学治疗,如介入放射学和外科手术,已被用于控制胆总管空肠吻合术后吻合口静脉曲张出血;然而,对于吻合口静脉曲张没有最好的治疗策略。胆总管空肠吻合术后吻合口静脉曲张直接流入肝内门静脉。因此,内镜下治疗这种情况比较困难,使用n -丁基-2-氰基丙烯酸酯进行内镜闭塞治疗是这种类型静脉曲张的首选治疗方法[1,2]。
{"title":"Endoscopic Treatment for Anastomotic Varices after Choledochojejunostomy","authors":"Takahiro Sato","doi":"10.4172/2167-0889.1000I103","DOIUrl":"https://doi.org/10.4172/2167-0889.1000I103","url":null,"abstract":"Ectopic varices are defined as portosystemic venous collaterals occurring anywhere in the gastrointestinal tract other than the esophagogastric region. Anastomotic varices after choledochojejunostomy should be considered when evaluating gastrointestinal hemorrhage in patients with previous surgery and mesenteric venous hypertension. Hemorrhaging from varices in the jejunal loop [1], with extrahepatic portal vein obstruction after choledochojejunostomy, is a rare condition but several articles have been published. Various medical treatments, such as interventional radiology and surgery, have been used to control bleeding from anastomotic varices after choledochojejunostomy; however, there is no best treatment strategy for anastomotic varices. Anastomotic varices after choledochojejunostomy drain directly into the intrahepatic portal vein. Therefore, endoscopic treatment is difficult for this condition and endoscopic obliterative therapy with N-butyl-2-cyanoacrylate is the preferred treatment for this type varices [1,2].","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86964688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
期刊
Journal of Liver
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