Pub Date : 2016-11-08DOI: 10.4172/2167-0889.C1.007
A. Kaul
{"title":"Possible role of estrogen receptors in gender susceptibility in the development of chronic infections and liver cancers","authors":"A. Kaul","doi":"10.4172/2167-0889.C1.007","DOIUrl":"https://doi.org/10.4172/2167-0889.C1.007","url":null,"abstract":"","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90401690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-04DOI: 10.4172/2167-0889.1000204
Chih‐Wen Lin, Chia-Chang Hsu, D. Perng, M. Yeh, Sien‐Sing Yang
Objectives: Taiwan has a high prevalence of hepatitis B viral (HBV) infection with rising alcoholic liver disease. We investigated the histological assessment of viral hepatitis B activity in patients with concomitant HBV infection and alcoholism. Methods: 229 patients (33 with concomitant heavy alcoholism and HBV infection, 114 with HBV infection alone, and 82 with heavy alcoholism alone) were enrolled between 2009 and 2012 at Cathy General hospital and E-Da hospital. Results: Patients with concomitant alcoholism and HBV infection are male predominant and younger. 97.4% and 91.4% patients have detectable HBV DNA in patients with HBV infection without or with alcoholism, respectively. Patients with concomitant HBV infection and alcoholism have much piecemeal necrosis, confluent necrosis, focal necrosis, portal inflammation, necroinflammatory grading, and cirrhosis with Ishak stage 5-6 fibrosis. Moreover, patients with concomitant HBV infection and alcoholism also have much pericelluar fibrosis, sclerosing hyaline necrosis, non-alcoholic fatty liver disease (NAFLD) ballooning, NAFLD activity score (NAS) and NAFLD Stage 4 fibrosis (P<0.001). However, patients with alcoholism alone have much more steatosis than those with HBV infection with and without alcoholism. Conclusions: Patients having concomitant alcoholism and HBV infection develop the histological features of both alcoholic liver disease and viral hepatitis B. The assessment of hepatitis B viral activity in alcoholic liver disease depends on detectable viral load and histological features of viral hepatitis B in patients with concomitant HBV infection and alcoholism.
{"title":"The Histological Assessment of Hepatitis B Viral Activity in Patients with Heavy Alcohol Consumption","authors":"Chih‐Wen Lin, Chia-Chang Hsu, D. Perng, M. Yeh, Sien‐Sing Yang","doi":"10.4172/2167-0889.1000204","DOIUrl":"https://doi.org/10.4172/2167-0889.1000204","url":null,"abstract":"Objectives: Taiwan has a high prevalence of hepatitis B viral (HBV) infection with rising alcoholic liver disease. We investigated the histological assessment of viral hepatitis B activity in patients with concomitant HBV infection and alcoholism. \u0000Methods: 229 patients (33 with concomitant heavy alcoholism and HBV infection, 114 with HBV infection alone, and 82 with heavy alcoholism alone) were enrolled between 2009 and 2012 at Cathy General hospital and E-Da hospital. \u0000Results: Patients with concomitant alcoholism and HBV infection are male predominant and younger. 97.4% and 91.4% patients have detectable HBV DNA in patients with HBV infection without or with alcoholism, respectively. Patients with concomitant HBV infection and alcoholism have much piecemeal necrosis, confluent necrosis, focal necrosis, portal inflammation, necroinflammatory grading, and cirrhosis with Ishak stage 5-6 fibrosis. Moreover, patients with concomitant HBV infection and alcoholism also have much pericelluar fibrosis, sclerosing hyaline necrosis, non-alcoholic fatty liver disease (NAFLD) ballooning, NAFLD activity score (NAS) and NAFLD Stage 4 fibrosis (P<0.001). However, patients with alcoholism alone have much more steatosis than those with HBV infection with and without alcoholism. \u0000Conclusions: Patients having concomitant alcoholism and HBV infection develop the histological features of both alcoholic liver disease and viral hepatitis B. The assessment of hepatitis B viral activity in alcoholic liver disease depends on detectable viral load and histological features of viral hepatitis B in patients with concomitant HBV infection and alcoholism.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"20 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82568727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-11-01DOI: 10.4172/2167-0889.1000203
María García, I. Hernández, F. Cuenca, Maria Villegas
Up until now, few cases of HBV reactivation after HCV therapy with new direct acting antivirals have been communicated, the majority of them without clinical repercussion. We present a case of fulminant hepatic failure for HBV reactivation in a patient infected with human immunodeficiency virus, after HCV therapy with DAAs.
{"title":"Acute B Hepatitis after Hepatitis C Virus Therapy with Direct Acting Antivirals in a Co-infected Patient with HIV","authors":"María García, I. Hernández, F. Cuenca, Maria Villegas","doi":"10.4172/2167-0889.1000203","DOIUrl":"https://doi.org/10.4172/2167-0889.1000203","url":null,"abstract":"Up until now, few cases of HBV reactivation after HCV therapy with new direct acting antivirals have been communicated, the majority of them without clinical repercussion. We present a case of fulminant hepatic failure for HBV reactivation in a patient infected with human immunodeficiency virus, after HCV therapy with DAAs.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"4 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74863637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-10-31DOI: 10.4172/2167-0889.1000E111
Xia Xuefeng, J. Park
Xia Xuefeng1* and Jun Yong Park2 1Principal Investigator, Center for Diabetes Research, The Methodist Hospital Research Institute, Houston, Texas, USA 2Department of Internal Medicine, Yonsei University College of Medicine, Korea *Corresponding author: Principal Investigator, Center for Diabetes Research, The Methodist Hospital Research Institute, Houston, Texas, USA, Tel: 713-441-6665; Email: xuefengx@gmail.com
{"title":"Hepatic Functions and its Disorders","authors":"Xia Xuefeng, J. Park","doi":"10.4172/2167-0889.1000E111","DOIUrl":"https://doi.org/10.4172/2167-0889.1000E111","url":null,"abstract":"Xia Xuefeng1* and Jun Yong Park2 1Principal Investigator, Center for Diabetes Research, The Methodist Hospital Research Institute, Houston, Texas, USA 2Department of Internal Medicine, Yonsei University College of Medicine, Korea *Corresponding author: Principal Investigator, Center for Diabetes Research, The Methodist Hospital Research Institute, Houston, Texas, USA, Tel: 713-441-6665; Email: xuefengx@gmail.com","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"5 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2016-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81981151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hepatocellular Carcinoma (HCC) is a most lethal malignancy. At first presentation, patients often already have advanced disease, and their treatment options for cure are very limited. Measurable biomarkers for early diagnosis of HCC are urgently needed to prolong the median over-all survival rate and reduce therapeutic expenditures. Proteomics is a powerful analytical technique that has been widely applied to search for cancer biomarkers, including in HCC. High-sensitivity, high-throughput, and non-invasive technologies should be capable of contributing to early diagnosis of HCC. In this review, we provide a flow scheme for proteomic study in HCC, and an overview of technical approaches for protein quantification. In addition, we present a broad summary of the HCC biomarkers proposed by studies in recent years, which have used various quantitative proteomic approaches.
{"title":"Global Analysis of Proteomics for Discovery of Biomarkers in Hepatocellular Carcinoma","authors":"Hong Li, Jiangbei Yuan, Fangbing Zhai, Jianqiang Zhang, Hua He, Xuefeng Xia","doi":"10.4172/2167-0889.1000202","DOIUrl":"https://doi.org/10.4172/2167-0889.1000202","url":null,"abstract":"Hepatocellular Carcinoma (HCC) is a most lethal malignancy. At first presentation, patients often already have \u0000 advanced disease, and their treatment options for cure are very limited. Measurable biomarkers for early diagnosis \u0000 of HCC are urgently needed to prolong the median over-all survival rate and reduce therapeutic expenditures. \u0000 Proteomics is a powerful analytical technique that has been widely applied to search for cancer biomarkers, including \u0000 in HCC. High-sensitivity, high-throughput, and non-invasive technologies should be capable of contributing to early \u0000 diagnosis of HCC. In this review, we provide a flow scheme for proteomic study in HCC, and an overview of technical \u0000 approaches for protein quantification. In addition, we present a broad summary of the HCC biomarkers proposed by \u0000 studies in recent years, which have used various quantitative proteomic approaches.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"7 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2016-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88881222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-27DOI: 10.4172/2167-0889.1000201
Muhammad Salman, N. Kasem, N. Saleh
The present study aims to compare the therapeutic effects between to extract scorpion venom (bradykinin potentiating factor; BPF) and aqueous extract of Sweet basil (Ocimum basilicum) on CCl4-induced toxicity of liver and kidney in albino rats. Rats were divided into 8 groups. Group (1) was served as normal group; Group (2) was injected intraperitoneal (i.p.) once a week for 3 weeks with BPF at a dose (1 μgm/g). Group (3) was received orally O. basilicum extract, twice a week for 6 weeks at dose (20 ml/kg). Group 4 was treated with the same doses of BPF and O. basilicum. Group (5) was injected i.p. with CCl4 (1 ml/kg), 3 times weekly, for 2 weeks and served as control group. Groups 6, 7 and 8 were injected i.p. with CCl4 then treated i.p. with BPF, orally with O. basilicum and BPF plus O. basilicum respectively. The results of the present study cleared that normal group (1) and groups (2, 3 and 4) showed no significant difference in all liver and kidney functions, besides antioxidant enzymes except creatinine and GSH, were highly significant increase in group (4). CCl4 caused a highly significant decrease in serum albumin, uric acid, besides Catalase, GSH, SOD activities in liver tissue, while there are an elevation in serum AST, ALT, ALP, γ-GT, creatinine and Urea, besides MDA and NO levels in liver tissue. While, groups (6, 7 and 8) revealed reverse effect in all parameters and recorded a remarkable improvement, comparing with normal group. It can be concluded that the treatment with the extract from the scorpion venom Buthus occitanus (BPF) is more effective than those of extract from the plant (O. basilicum) against the toxicity of liver and kidney-induced by CCl4 in albino rats. In addition, the hepato-ameliorating and antioxidant effects of two extracts were found to be better than those of extract of BPF or O. basilicum indepently.
{"title":"Comparative Effects of Scorpion Venom and Aqueous Basil ( Ocimum basilicum ) Leaves Extracts on Ccl4-induced Toxicity in Albino Rats","authors":"Muhammad Salman, N. Kasem, N. Saleh","doi":"10.4172/2167-0889.1000201","DOIUrl":"https://doi.org/10.4172/2167-0889.1000201","url":null,"abstract":"The present study aims to compare the therapeutic effects between to extract scorpion venom (bradykinin potentiating factor; BPF) and aqueous extract of Sweet basil (Ocimum basilicum) on CCl4-induced toxicity of liver and kidney in albino rats. Rats were divided into 8 groups. Group (1) was served as normal group; Group (2) was injected intraperitoneal (i.p.) once a week for 3 weeks with BPF at a dose (1 μgm/g). Group (3) was received orally O. basilicum extract, twice a week for 6 weeks at dose (20 ml/kg). Group 4 was treated with the same doses of BPF and O. basilicum. Group (5) was injected i.p. with CCl4 (1 ml/kg), 3 times weekly, for 2 weeks and served as control group. Groups 6, 7 and 8 were injected i.p. with CCl4 then treated i.p. with BPF, orally with O. basilicum and BPF plus O. basilicum respectively. The results of the present study cleared that normal group (1) and groups (2, 3 and 4) showed no significant difference in all liver and kidney functions, besides antioxidant enzymes except creatinine and GSH, were highly significant increase in group (4). CCl4 caused a highly significant decrease in serum albumin, uric acid, besides Catalase, GSH, SOD activities in liver tissue, while there are an elevation in serum AST, ALT, ALP, γ-GT, creatinine and Urea, besides MDA and NO levels in liver tissue. While, groups (6, 7 and 8) revealed reverse effect in all parameters and recorded a remarkable improvement, comparing with normal group. It can be concluded that the treatment with the extract from the scorpion venom Buthus occitanus (BPF) is more effective than those of extract from the plant (O. basilicum) against the toxicity of liver and kidney-induced by CCl4 in albino rats. In addition, the hepato-ameliorating and antioxidant effects of two extracts were found to be better than those of extract of BPF or O. basilicum indepently.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"21 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88162528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-19DOI: 10.4172/2167-0889.1000200
Muhammad Salman, Abdel-rahman
This study, was established five groups of albino rats to determine the therapeutic effect of Curcuma longa and ursofalk against the toxicity of CC14 in liver and kidney. Group (1) was received orally NaCl 0.9% and used as a normal group. Group (2) was injected intraperitoneal (i.p.) with CCl4 (1 ml/kg), 3 times weekly, for 2 weeks. Group (3) was given orally Ursofalk (100 mg/kg per body weight), group (4) was given orally Curcuma longa (100 mg/kg body weight) and group (5) was given the same doses of Ursofalk plus Curcuma longa for 30 days respectively, post-injected intraperitoneal (i.p.) with CCl4 (1 ml/kg) 3 times weekly, for 2 weeks. Two blood samples were collected, for hematological and biochemical parameters. Specimens from liver and kidney were collected for histopathological examination. Group (2) revealed a highly significant decrease in total RBCs, platelets, Hb and PCV, serum uric acid, albumin, glucose, HDL-cholesterol, besides catalase, GSH, SOD activities in liver tissue, while WBCs, serum ALT, AST, ALP, γ-GT, creatinine, urea, cholesterol, triglycerides and LDL-cholesterol levels, besides Malondialdehyde and Nitric Oxide levels in liver tissue showed a highly significant increase. Meanwhile, groups (3, 4 and 5) displayed reverse effect in all parameters and return to normal. The histological results displayed inflammation with necrosis and degenerative changes in group (2), while remain groups showed mild changes particularly in group (5). It could be concluded that CCl4 induced destruction in liver and kidney, which showed a clear improvement by using of Ursofalk and Curcuma longa as treatment.
{"title":"Patho-physiological studies on the Reverse Effect of Curcumin (Curcuma longa, Zingiberaceae) and Ursofalk (Ursodeoxycholic acid) against the Toxicity of Carbon Tetrachloride on Albino Rats","authors":"Muhammad Salman, Abdel-rahman","doi":"10.4172/2167-0889.1000200","DOIUrl":"https://doi.org/10.4172/2167-0889.1000200","url":null,"abstract":"This study, was established five groups of albino rats to determine the therapeutic effect of Curcuma longa and ursofalk against the toxicity of CC14 in liver and kidney. Group (1) was received orally NaCl 0.9% and used as a normal group. Group (2) was injected intraperitoneal (i.p.) with CCl4 (1 ml/kg), 3 times weekly, for 2 weeks. Group (3) was given orally Ursofalk (100 mg/kg per body weight), group (4) was given orally Curcuma longa (100 mg/kg body weight) and group (5) was given the same doses of Ursofalk plus Curcuma longa for 30 days respectively, post-injected intraperitoneal (i.p.) with CCl4 (1 ml/kg) 3 times weekly, for 2 weeks. Two blood samples were collected, for hematological and biochemical parameters. Specimens from liver and kidney were collected for histopathological examination. Group (2) revealed a highly significant decrease in total RBCs, platelets, Hb and PCV, serum uric acid, albumin, glucose, HDL-cholesterol, besides catalase, GSH, SOD activities in liver tissue, while WBCs, serum ALT, AST, ALP, γ-GT, creatinine, urea, cholesterol, triglycerides and LDL-cholesterol levels, besides Malondialdehyde and Nitric Oxide levels in liver tissue showed a highly significant increase. Meanwhile, groups (3, 4 and 5) displayed reverse effect in all parameters and return to normal. The histological results displayed inflammation with necrosis and degenerative changes in group (2), while remain groups showed mild changes particularly in group (5). It could be concluded that CCl4 induced destruction in liver and kidney, which showed a clear improvement by using of Ursofalk and Curcuma longa as treatment.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"41 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77843604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-08-10DOI: 10.4172/2167-0889.1000198
S. McCabe, M. Lim, S. Maddineni, G. Rozenblit
{"title":"Watershed Hepatocellular Carcinoma â Utility of Cone Beam CT forTranscatheter Therapy and Case Report","authors":"S. McCabe, M. Lim, S. Maddineni, G. Rozenblit","doi":"10.4172/2167-0889.1000198","DOIUrl":"https://doi.org/10.4172/2167-0889.1000198","url":null,"abstract":"","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"77 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2016-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82668668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-28DOI: 10.4172/2167-0889.1000197
Junichi Taira, Y. Imai, Takatomo Sano, K. Sugimoto, Yoshihiro Furuichi, I. Nakamura, F. Moriyasu
Objectives: We observed the time-course changes of blood flow in non-hypervascular hepatocellular nodules that showed hypointensity in the hepatobiliary phase on Gd-EOB-DTPA-enhanced magnetic resonance imaging (EOB-MRI), and evaluated the relationship between hypervascular change and the status of blood supply in the nodules. Methods: The study included 69 hepatocellular nodules in 33 patients demonstrating hypointensity in the hepatobiliary phase on EOB-MRI and showing non-hypervascular features on CT during hepatic arteriography (CTHA) performed during the same period. Results: In relation to blood flow on CTHA/ CT during arterial portography (CTAP), the cumulative rate of hypervascular change at 52 weeks was 0.0% for iso/iso, 29.7% for hypo/iso, 61.5% for iso/hypo, and 55.0% for hypo/hypo. Multivariate analysis using COX proportional hazards regression showed that CTAP findings (hypodensity) and CTHA findings (hypo-density) were significant variables for hypervascular change. Conclusions: In cases of non-hypervascular hepatocellular tumors, nodules with decreased arterial or portal blood flow that show hypointensity in the hepatobiliary phase on EOB-MRI are likely to develop into typical hepatocellular carcinoma in a shorter time.
{"title":"Relationship between the Status of Blood Supply in the Non-hypervascular Hepatocellular Nodules among Chronic Liver Diseases and the Hypervascular Change","authors":"Junichi Taira, Y. Imai, Takatomo Sano, K. Sugimoto, Yoshihiro Furuichi, I. Nakamura, F. Moriyasu","doi":"10.4172/2167-0889.1000197","DOIUrl":"https://doi.org/10.4172/2167-0889.1000197","url":null,"abstract":"Objectives: We observed the time-course changes of blood flow in non-hypervascular hepatocellular nodules that showed hypointensity in the hepatobiliary phase on Gd-EOB-DTPA-enhanced magnetic resonance imaging (EOB-MRI), and evaluated the relationship between hypervascular change and the status of blood supply in the nodules. Methods: The study included 69 hepatocellular nodules in 33 patients demonstrating hypointensity in the hepatobiliary phase on EOB-MRI and showing non-hypervascular features on CT during hepatic arteriography (CTHA) performed during the same period. Results: In relation to blood flow on CTHA/ CT during arterial portography (CTAP), the cumulative rate of hypervascular change at 52 weeks was 0.0% for iso/iso, 29.7% for hypo/iso, 61.5% for iso/hypo, and 55.0% for hypo/hypo. Multivariate analysis using COX proportional hazards regression showed that CTAP findings (hypodensity) and CTHA findings (hypo-density) were significant variables for hypervascular change. Conclusions: In cases of non-hypervascular hepatocellular tumors, nodules with decreased arterial or portal blood flow that show hypointensity in the hepatobiliary phase on EOB-MRI are likely to develop into typical hepatocellular carcinoma in a shorter time.","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"82 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74088938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-07-07DOI: 10.4172/2167-0889.1000I103
Takahiro Sato
Ectopic varices are defined as portosystemic venous collaterals occurring anywhere in the gastrointestinal tract other than the esophagogastric region. Anastomotic varices after choledochojejunostomy should be considered when evaluating gastrointestinal hemorrhage in patients with previous surgery and mesenteric venous hypertension. Hemorrhaging from varices in the jejunal loop [1], with extrahepatic portal vein obstruction after choledochojejunostomy, is a rare condition but several articles have been published. Various medical treatments, such as interventional radiology and surgery, have been used to control bleeding from anastomotic varices after choledochojejunostomy; however, there is no best treatment strategy for anastomotic varices. Anastomotic varices after choledochojejunostomy drain directly into the intrahepatic portal vein. Therefore, endoscopic treatment is difficult for this condition and endoscopic obliterative therapy with N-butyl-2-cyanoacrylate is the preferred treatment for this type varices [1,2].
{"title":"Endoscopic Treatment for Anastomotic Varices after Choledochojejunostomy","authors":"Takahiro Sato","doi":"10.4172/2167-0889.1000I103","DOIUrl":"https://doi.org/10.4172/2167-0889.1000I103","url":null,"abstract":"Ectopic varices are defined as portosystemic venous collaterals occurring anywhere in the gastrointestinal tract other than the esophagogastric region. Anastomotic varices after choledochojejunostomy should be considered when evaluating gastrointestinal hemorrhage in patients with previous surgery and mesenteric venous hypertension. Hemorrhaging from varices in the jejunal loop [1], with extrahepatic portal vein obstruction after choledochojejunostomy, is a rare condition but several articles have been published. Various medical treatments, such as interventional radiology and surgery, have been used to control bleeding from anastomotic varices after choledochojejunostomy; however, there is no best treatment strategy for anastomotic varices. Anastomotic varices after choledochojejunostomy drain directly into the intrahepatic portal vein. Therefore, endoscopic treatment is difficult for this condition and endoscopic obliterative therapy with N-butyl-2-cyanoacrylate is the preferred treatment for this type varices [1,2].","PeriodicalId":16145,"journal":{"name":"Journal of Liver","volume":"5 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86964688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}