Journal of Intellectual Disability Research最新文献_第5页

Drug burden index of people ageing with intellectual disability and cognitive complaints attending a specialist memory service 接受记忆专科服务的智障和认知障碍老年人的药物负担指数。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-26 DOI: 10.1111/jir.13180

R. M. Vaughan, M. O'Dwyer, J. Tyrrell, S. P. Kennelly, M. McCarron

Background

Medications with sedative or anticholinergic properties should be prescribed with caution in those with cognitive complaints. This is particularly relevant in people ageing with an intellectual disability (ID). Higher drug burden index (DBI) scores are associated with increased frailty and falls and reduced quality of life in older people and increased risk of adverse effects (daytime somnolence, constipation) in those with ID. While previous studies have shown that the ID population has higher rates of drug burden and a higher propensity to be prescribed an antipsychotic than the general population, the degree of burden has not been assessed specifically in those with ID and cognitive complaints.

Methods

We assessed drug burden in a cohort of sequential referrals to a national memory service for people with ID. All patients were referred for assessment of cognitive complaints (self-reported or caregiver-reported problems with memory or cognition). DBI was calculated individually for each participant, and the impact of aetiology of ID, level of ID, age, psychiatric/neurological comorbidities and diagnostic outcome on DBI scores was assessed.

Results

The study population was 58.6% female with a median age of 55 years and aetiology of ID was Down syndrome (DS) in 71.3%. Consensus diagnosis was Alzheimer's dementia in 40.2%, mild cognitive impairment in 29.9% and cognitively unimpaired from baseline in 25.3%. Medication use was high with 95.4% taking medications, with a median number of medications of 4 (interquartile range 4) and a rate of polypharmacy (≥5 medications) of 51.7%. Overall, 65.5% were exposed to sedative or anticholinergic medications with 39.1% exposed to a clinically significant DBI score >1. Those with psychiatric comorbidities, non-DS aetiology or epilepsy were significantly more likely to have a DBI score >1.

Conclusions

People with ID and incipient cognitive complaints have a high level of drug burden, which concerningly exceeds that of the general population.

背景：对于有认知障碍的患者，应慎用具有镇静或抗胆碱能特性的药物。这一点对于患有智力障碍（ID）的老年人尤为重要。药物负担指数（DBI）得分越高，老年人体弱、跌倒和生活质量下降的情况就越多，智障人士出现不良反应（白天嗜睡、便秘）的风险也越高。以往的研究表明，与普通人群相比，智障人群的药物负担率更高，被处方抗精神病药物的倾向性也更高，但还没有专门针对智障和认知障碍患者的药物负担程度进行过评估：我们评估了一组连续转诊至国家记忆服务机构的智障人士的药物负担。所有转诊患者均接受了认知症状评估（自我报告或护理人员报告的记忆或认知问题）。对每位参与者的 DBI 进行单独计算，并评估智障病因、智障程度、年龄、精神/神经系统合并症和诊断结果对 DBI 分数的影响：研究对象中 58.6% 为女性，中位年龄为 55 岁，71.3% 的 ID 病因是唐氏综合征（DS）。40.2%的人被确诊为阿尔茨海默氏痴呆症，29.9%的人被确诊为轻度认知障碍，25.3%的人被确诊为基线认知功能未受损。药物使用率很高，95.4% 的人在服药，药物中位数为 4 种（四分位间范围为 4），多药（≥5 种药物）率为 51.7%。总体而言，65.5%的患者服用镇静剂或抗胆碱能药物，39.1%的患者服用具有临床意义的DBI评分>1：结论：患有智障和初期认知障碍的患者的药物负担很重，超过了普通人群的药物负担，令人担忧。

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引用次数: 0

Age and sex-specific risk in fractures with Down syndrome in a retrospective case–control study from Germany 德国一项回顾性病例对照研究中唐氏综合征患者骨折的年龄和性别风险。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-25 DOI: 10.1111/jir.13183

S. Krieg, A. Krieg, K. Kostev

Background

The increasing life expectancy of individuals with Down syndrome has led to a growing awareness of mid- and late-life conditions.

Methods

Based on the Disease Analyser database (IQVIA), this retrospective cohort study compared adults ≥18 years of age with Down syndrome (ICD-10: Q90) in general practices in Germany with a propensity score-matched cohort without Down syndrome. The outcome was the first diagnosis of a fracture within 5 years of the index date. The cumulative incidence of fractures over a 5-year period was presented using Kaplan–Meier curves. Univariable Cox regression analyses by age group and sex were performed to assess the association between Down syndrome and fractures.

Results

A total of 2547 individuals with Down syndrome and 12 735 individuals without Down syndrome were included in the study. A significantly higher cumulative fracture incidence within 5 years was observed in the age group 51–60 years (9.3% Down syndrome vs. 4.8% without Down syndrome, P = 0.003) as well as in the age group >60 years (20.3% Down syndrome vs. 8.6% without Down syndrome, P < 0.001) compared with the cohort without Down syndrome. Regression analysis showed a significant association between Down syndrome and fracture risk in women with Down syndrome aged 51–60 years (hazard ratio [HR] = 1.60; 95% confidence interval [CI]: 1.13–2.26), and in those aged 51–60 years (HR = 2.08; 95% CI: 1.27–3.41) and >60 years (HR = 2.98; 95% CI: 1.87–4.73)), but not in men. When comparing fractures in individuals with and without Down syndrome, shoulder and arm fractures were most common in the Down syndrome cohort.

Conclusion

The results of our study indicate a positive association between individuals with Down syndrome and subsequent fractures in women and those aged >50 years. Prevention of falls appears to be particularly important in these populations. However, future studies should clarify the extent to which socio-economic factors, such as housing, play a role in this context.

背景：随着唐氏综合征患者预期寿命的延长，他们对中年和晚年状况的认识也在不断提高：随着唐氏综合征患者预期寿命的延长，人们对中晚期疾病的认识也在不断提高：这项回顾性队列研究以 Disease Analyser 数据库（IQVIA）为基础，比较了德国全科医生中年龄≥18 岁的唐氏综合征成人（ICD-10：Q90）与无唐氏综合征的倾向得分匹配队列。研究结果是在索引日期后的 5 年内首次诊断出骨折。5 年内骨折的累积发生率采用 Kaplan-Meier 曲线表示。按年龄组和性别进行单变量 Cox 回归分析，以评估唐氏综合征与骨折之间的关系：研究共纳入了 2547 名唐氏综合征患者和 12 735 名非唐氏综合征患者。在 51-60 岁年龄组（9.3% 的唐氏综合征患者与 4.8% 的非唐氏综合征患者，P = 0.003）和大于 60 岁年龄组（20.3% 的唐氏综合征患者与 8.6% 的非唐氏综合征患者，P 60 岁（HR = 2.98；95% CI：1.87-4.73））中观察到，5 年内累积骨折发生率明显较高，但在男性中没有观察到。在比较有唐氏综合征和无唐氏综合征患者的骨折情况时，肩部和手臂骨折在唐氏综合征人群中最为常见：结论：我们的研究结果表明，患有唐氏综合症的人与女性和年龄大于 50 岁的人随后发生骨折之间存在正相关。在这些人群中，预防跌倒似乎尤为重要。不过，未来的研究应明确住房等社会经济因素在这方面的作用。

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引用次数: 0

SSBP 26th International Research Symposium, Bali, Indonesia: Abstracts for presentation 第 26 届 SSBP 教育日暨国际研究研讨会：遗传和神经发育障碍的早期识别和治疗。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-22 DOI: 10.1111/jir.13174

引用次数: 0

Early identification and treatment of genetic and neurodevelopmental disorders 遗传和神经发育障碍的早期识别和治疗。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-22 DOI: 10.1111/jir.13175

T. I. Winarni, A. Utari, N. Maharani, T. A. Sumekar, N. R. B. Sihombing, R. J. Hagerman

引用次数: 0

SSBP 26th International Research Symposium, Bali, Indonesia: Keynote Abstracts for presentation 第 26 届 SSBP 教育日暨国际研究研讨会：遗传和神经发育障碍的早期识别和治疗。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-22 DOI: 10.1111/jir.13173

引用次数: 0

Immersive virtual reality is more effective than non-immersive devices for developing real-world skills in people with intellectual disability 与非沉浸式设备相比，沉浸式虚拟现实在开发智障人士的真实世界技能方面更为有效。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-21 DOI: 10.1111/jir.13177

A. Franze, T. Loetscher, N. C. Gallomarino, A. Szpak, G. Lee, S. C. Michalski

Background

People with intellectual disability (ID) demonstrate persistent challenges around developing life skills. Immersive virtual reality (IVR) is gaining interest as a tool for training life skills as it enables individuals to engage in hands-on learning in a safe, controlled and repeatable environment. However, there are concerns about the potential drawbacks of IVR, such as cybersickness and practical challenges with using the equipment, which may hinder its widespread adoption in educational settings. The current study aimed to compare the effectiveness of training in IVR and a non-immersive virtual environment for improving real-world skills in people with ID.

Methods

In the present study, 36 adults (16 female, 20 male) with ID were recruited from a disability organisation. Participants completed a real-world assessment of waste management skills before and after training in either the IVR or non-immersive group.

Results

Consistent with our hypotheses, the IVR group scored significantly higher in the real-world assessment after virtual training (d = 1), and at the 1-week follow-up (d = 1.12), compared with the non-immersive group. Further analyses showed that the IVR group, but not the non-immersive group, significantly improved performance in the real-world assessment across timepoints.

Conclusions

The findings indicate that IVR was more effective for improving and retaining real-world waste management skills. This study supports IVR as a viable tool for professionals and caregivers to develop skills for independent living among people with ID.

背景：智障人士在发展生活技能方面一直面临挑战。沉浸式虚拟现实（IVR）作为一种训练生活技能的工具正受到越来越多的关注，因为它能让个人在安全、可控和可重复的环境中进行实践学习。然而，IVR 的潜在缺点也令人担忧，例如晕网和使用设备时的实际困难，这可能会阻碍其在教育环境中的广泛应用。本研究旨在比较 IVR 培训和非沉浸式虚拟环境对提高智障人士实际技能的效果：本研究从一家残疾人组织招募了 36 名成年智障人士（16 名女性，20 名男性）。参加者在 IVR 或非沉浸式组培训前后完成了对废物管理技能的真实世界评估：结果：与我们的假设一致，与非浸入式组相比，IVR 组在虚拟培训后（d = 1）和一周随访时（d = 1.12）的真实世界评估中得分明显更高。进一步的分析表明，IVR 组（而非沉浸式组）在不同时间点的真实世界评估中的表现都有显著提高：结论：研究结果表明，IVR 对提高和保持真实世界中的废物管理技能更为有效。这项研究支持将 IVR 作为一种可行的工具，供专业人员和护理人员培养智障人士的独立生活技能。

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引用次数: 0

Feasibility and findings of electrocardiogram recording in older adults with intellectual disabilities: results of the Healthy Ageing and Intellectual Disabilities study 智障老年人心电图记录的可行性和结果：健康老龄化和智障研究的结果。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-15 DOI: 10.1111/jir.13181

M. J. de Leeuw, M. N. Böhmer, M. J. G. Leening, J. A. Kors, P. J. E. Bindels, A. Oppewal, D. A. M. Maes-Festen

Background

Older adults with intellectual disabilities (ID) have a high risk of cardiovascular diseases (CVD). At the same time, challenging diagnostic work-up increases the likelihood of underdiagnosis of CVD in this population. To limit this underdiagnosis, it would be beneficial to use objective measures such as the electrocardiogram (ECG). However, little is known about the feasibility of ECG recording and the prevalence of ECG abnormalities in this population. Therefore, the aims of this study were to investigate the feasibility of resting ECG recording, to study the prevalence of ECG abnormalities, and to compare the frequency of ECG abnormalities with medical records in older adults with ID.

Method

A cross-sectional study was performed within a cohort of older adults (≥60 years) with ID as part of the Healthy Ageing and Intellectual Disabilities (HA-ID) study. A resting 12-lead ECG was attempted, and the ECG recording was considered feasible if the recording could be made and if the ECG could be interpreted by a cardiologist and the Modular ECG Analysis System (MEANS). ECGs were assessed for the presence of ECG abnormalities and medical record review was performed. If the cardiologist or MEANS concluded that there was evidence of myocardial infarction, atrial fibrillation or QTc prolongation on the ECG in the absence of this ECG diagnosis in the participant's medical record, this was classified as a previously undiagnosed ECG diagnosis.

Results

ECG recording was feasible in 134 of the 200 participants (67.0%). Of these 134 participants (70.6 ± 5.8 years; 52.2% female), 103 (76.9%) had one or more ECG abnormality, with the most prevalent being prolonged P-wave duration (27.6%), QTc prolongation (18.7%), minor T-wave abnormalities (17.9%), first degree atrioventricular block (12.7%) and myocardial infarction (6.7%). Eight out of 9 (88.9%) myocardial infarctions and all cases of (significant) QTc prolongation (100%) were previously undiagnosed.

Conclusions

This study showed that ECG recording is feasible in the majority of older adults with ID and revealed a substantial underdiagnosis of ECG abnormalities. These results stress the importance of ECG recording and warrant further research into the yield of opportunistic ECG screening in older adults with ID.

背景：智障老年人罹患心血管疾病（CVD）的风险很高。同时，高难度的诊断工作增加了这一人群心血管疾病诊断不足的可能性。为了限制这种漏诊，使用心电图（ECG）等客观测量方法将是有益的。然而，人们对心电图记录的可行性以及该人群心电图异常的发生率知之甚少。因此，本研究的目的是调查静息心电图记录的可行性，研究心电图异常的发生率，并将智障老年人心电图异常的频率与医疗记录进行比较：方法：作为健康老龄化和智力残疾（HA-ID）研究的一部分，在一组患有智障的老年人（≥60 岁）中进行了一项横断面研究。研究人员尝试了静息 12 导联心电图，如果心电图能够记录，并且心电图能够由心脏病专家和模块化心电图分析系统 (MEANS) 进行解读，则认为心电图记录是可行的。评估心电图是否存在异常，并对病历进行审查。如果心脏病专家或模块化心电图分析系统（MEANS）认为心电图上存在心肌梗死、心房颤动或 QTc 延长的证据，而参与者的医疗记录中没有该心电图诊断，则将其归类为先前未诊断的心电图诊断：200 名参与者中有 134 人（67.0%）可以进行心电图记录。在这 134 名参与者（70.6 ± 5.8 岁；52.2% 为女性）中，103 人（76.9%）有一种或多种心电图异常，其中最常见的是 P 波持续时间延长（27.6%）、QTc 延长（18.7%）、轻微 T 波异常（17.9%）、一级房室传导阻滞（12.7%）和心肌梗死（6.7%）。9例心肌梗死中的8例（88.9%）和所有（明显）QTc延长的病例（100%）以前都未被诊断出来：这项研究表明，对大多数患有智障的老年人进行心电图记录是可行的，并揭示了心电图异常的严重漏诊。这些结果强调了心电图记录的重要性，值得进一步研究对患有智障的老年人进行机会性心电图筛查的收益。

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引用次数: 0

Description and predictors of self-determination in males and females with fragile X syndrome on the verge of adulthood 罹患脆性 X 综合征的男性和女性濒临成年时自我决定能力的描述和预测因素。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-12 DOI: 10.1111/jir.13182

L. Friedman, C. Moser, A. J. Thurman, J. L. Taylor, L. Abbeduto, J. Klusek

<div> <section> <h3> Background</h3> <p>Self-determination refers to setting goals and making decisions regarding one's own life with support from others as needed. Research on people with intellectual and developmental disabilities has established the importance of self-determination for quality of life outcomes, such as increased independence and life satisfaction. However, self-determination has not been characterised specifically in fragile X syndrome (FXS), the leading inherited cause of intellectual disability. Relative to youth with other forms of intellectual and developmental disabilities, youth with FXS may face exceptional barriers to the development of self-determined behaviour. In addition to intellectual disability, the FXS behavioural profile is characterised by high rates of autism and anxiety that may further limit opportunities for youth with FXS. The heritable nature of the condition can also yield a distinctive family environment, with siblings and parents also living with fragile X or its associated conditions. Considering these unique challenges, the present study examined self-determination in young adult males and females with FXS and explored whether factors such as language skills, adaptive behaviour and autism traits were associated with self-determination capacity and opportunities.</p> </section> <section> <h3> Methods</h3> <p>The present study included 9 females and 36 males with FXS between the ages of 17 and 25 years. Caregivers (mothers or fathers) completed the American Institute for Research Self-Determination Assessment, which is a questionnaire that yields three scores: self-determination capacity, opportunities for self-determination at home and opportunities for self-determination at school.</p> </section> <section> <h3> Results</h3> <p>Caregivers endorsed a wide range of self-determination capacity and opportunities, with ratings for opportunities at home and school exceeding ratings of capacity. Better adaptive behaviour skills were associated with more self-determination capacity, and the presence of more autism traits was associated with fewer opportunities at school.</p> </section> <section> <h3> Conclusions</h3> <p>Results from this study contribute to our understanding of avenues to best support young adults with FXS as they transition to adulthood. Our findings also have implications for practice, such that interventions targeting adaptive behaviours and self-determination may be an effective approach for promoting autonomy and independence for young adults with FXS. Additionally, caregivers and educat

背景：自决是指在他人的必要支持下，为自己的生活设定目标并做出决定。对智力和发育障碍人士的研究已经证实，自我决定对提高生活质量具有重要意义，例如提高独立性和生活满意度。然而，对于脆性 X 综合症（FXS）这种导致智力残疾的主要遗传病因，人们还没有专门研究过他们的自决能力。与患有其他形式智力和发育障碍的青少年相比，患有脆性 X 射线综合症的青少年在发展自我决定行为方面可能面临特殊障碍。除智力障碍外，FXS 行为特征的另一个特点是自闭症和焦虑症的高发率，这可能会进一步限制 FXS 患者的机会。这种疾病的遗传性还可能导致独特的家庭环境，因为兄弟姐妹和父母也患有脆性 X 或相关疾病。考虑到这些独特的挑战，本研究考察了患有 FXS 的年轻成年男性和女性的自我决定能力，并探讨了语言技能、适应行为和自闭症特征等因素是否与自我决定能力和机会相关：本研究包括 9 名女性和 36 名男性 FXS 患者，年龄在 17 岁至 25 岁之间。照顾者（母亲或父亲）填写了美国研究所自决评估问卷，该问卷可得出三项评分：自决能力、在家中的自决机会和在学校的自决机会：照顾者对自决能力和自决机会的认可范围很广，对家庭和学校自决机会的评分超过了对自决能力的评分。较好的适应行为技能与较高的自决能力相关，而较多的自闭症特征与较少的在校机会相关：这项研究的结果有助于我们了解如何在 FXS 青少年向成年过渡的过程中为他们提供最佳支持。我们的研究结果还对实践产生了影响，例如，针对适应行为和自我决定的干预措施可能是促进 FXS 青少年自主和独立的有效方法。此外，照顾者和教育者应继续为他们提供实践自我决定的机会，无论他们对自己能力的认知如何。

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引用次数: 0

Stressful life events, post-traumatic stress disorder symptoms and mental health in individuals with intellectual disabilities: a scoping review 智障人士的生活压力事件、创伤后应激障碍症状和心理健康：范围界定综述。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-11 DOI: 10.1111/jir.13178

M. Rouleaux, N. Peters-Scheffer, R. Lindauer, L. Mevissen, R. Didden

<div> <section> <h3> Background</h3> <p>Stressful life events are events that do not fulfil the A criterion of PTSD in the DSM-5(TR) but are perceived as negative by the person. There is an ongoing debate about the usefulness of the A criterion as a gate criterion for PTSD, and especially regarding which events qualify as traumatic or stressful life events. This debate is particularly important for individuals with intellectual disabilities (ID) or borderline intellectual functioning (BIF), as they seem to be more likely to experience traumatic and stressful life events than their peers without ID-BIF and appear to be more susceptible to the disruptive effects of these events. As a result, people with ID-BIF are more likely to develop mental health and behavioural problems. There is insufficient knowledge about how the relationship between stressful life events and PTSD symptoms should be interpreted, how traumatic and stressful life events are defined and distinguished in people with ID, and whether the A criterion should be broadened for individuals with ID-BIF. The aim of this scoping review was to understand stressful life events and their relationship with PTSD symptoms, other mental health and/or behavioural problems in individuals with ID-BIF.</p> </section> <section> <h3> Methods</h3> <p>The scoping review was conducted in accordance with the JBI methodology for scoping reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR).</p> </section> <section> <h3> Results</h3> <p>Thirty-eight studies were included. Five studies focused on stressful life events and PTSD symptoms. The other studies examined associations between stressful life events and other mental health and/or behavioural problems. Most of the studies did not clearly differentiate between stressful and traumatic events according to the A criterion of PTSD in the DSM-IV (TR) or DSM-5(TR). Of the six studies in which stressful life events were specified and could be distinguished from traumatic events, one found a positive association between PTSD symptoms and stressful life events and five showed weak to strong positive associations with other mental health and/or behavioural problems.</p> </section> <section> <h3> Conclusions</h3> <p>PTSD symptoms following stressful life events in individuals with ID-BIF are underrepresented in the literature. The lack of a clear definition of stressful life events leads to a gap in the knowledge on whether and how stressful life events may lead to PTSD symptoms, other mental he

背景：应激性生活事件是指不符合 DSM-5（TR）中创伤后应激障碍 A 标准，但被患者视为负面的事件。关于 A 标准作为 PTSD 门槛标准的实用性，特别是关于哪些事件符合创伤性或应激性生活事件的标准，一直存在争论。这一争论对于智障（ID）或边缘智力功能（BIF）患者尤为重要，因为他们似乎比没有智障-边缘智力功能的同龄人更有可能经历创伤性和压力性生活事件，而且似乎更容易受到这些事件的破坏性影响。因此，ID-BIF 患者更容易出现心理健康和行为问题。对于如何解释生活压力事件与创伤后应激障碍症状之间的关系，如何定义和区分 ID 患者的创伤性和生活压力事件，以及是否应扩大 ID-BIF 患者的 A 级标准，目前还缺乏足够的了解。本范围综述旨在了解生活压力事件及其与ID-BIF患者的创伤后应激障碍症状、其他心理健康和/或行为问题之间的关系：范围界定综述根据 JBI 范围界定综述方法和范围界定综述系统综述和荟萃分析扩展首选报告项目（PRISMA-ScR）进行：共纳入 38 项研究。其中五项研究侧重于生活压力事件和创伤后应激障碍症状。其他研究则探讨了生活压力事件与其他心理健康和/或行为问题之间的关联。大多数研究并没有根据 DSM-IV（TR）或 DSM-5（TR）中创伤后应激障碍的 A 标准明确区分压力事件和创伤事件。在明确指出生活压力事件并可将其与创伤事件区分开来的六项研究中，一项研究发现创伤后应激障碍症状与生活压力事件呈正相关，五项研究发现创伤后应激障碍症状与其他心理健康和/或行为问题呈弱到强的正相关：结论：ID-BIF 患者在生活压力事件后出现的创伤后应激障碍症状在文献中的代表性不足。由于缺乏对压力性生活事件的明确定义，因此在有关压力性生活事件是否以及如何导致ID-BIF患者出现创伤后应激障碍症状、其他心理健康和/或行为问题的知识方面存在空白。因此，对于创伤后应激障碍A标准是否适合ID-BIF患者，还不能做出一般性结论或建议。专家临床经验研究表明，应考虑为ID-BIF患者扩大创伤后应激障碍A标准的适用范围，因此需要开展进一步研究，以确定应激性生活事件在创伤后应激障碍症状中的作用，并为ID-BIF患者的评估和有效治疗提供依据。

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引用次数: 0

Laboratory-based measures of executive function and daily living skills in young children with Down syndrome: informing future interventions 基于实验室的唐氏综合症幼儿执行功能和日常生活技能测量方法：为未来的干预措施提供依据。

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research

Pub Date : 2024-08-07 DOI: 10.1111/jir.13176

K. Van Deusen, M. A. Prince, M. M. Walsh, A. J. Esbensen, L. R. Patel, M. E. Pinks, A. J. Thurman, L. Abbeduto, L. A. Daunhauer, D. J. Fidler

Background

Adaptive behaviour refers to the practical skills necessary for independence and is considered a high-priority intervention target for children with neurogenetic conditions associated with intellectual disability, like Down syndrome (DS). Daily living skills (DLS) are a critical aspect of adaptive behaviour, but they have received little intervention attention, possibly because they involve a wide variety of skills across many settings. The present study aimed to advance DLS intervention science by examining the concurrent and longitudinal association between DLS performances and a cognitive skillset hypothesised to support DLS skill acquisition, executive function (EF).

Methods

Participants were 71 children with DS between the ages of 2.5 and 8.7 years (M = 5.23 years; standard deviation = 1.65) who completed a battery of adapted EF tasks and a primary caregiver who completed the Vineland Adaptive Behavior Scales 3rd Edition Parent/Caregiver Comprehensive Report Form. A subset of caregivers also provided 6- and 12-month follow-up adaptive behaviour information.

Results

Results demonstrated a positive association between EF task performance and DLS standard scores and v-scores both concurrently and longitudinally.

Conclusions

The findings have implications for potential future intervention approaches that aim to strengthen DLS performances by advancing EF skills in this population.

背景：适应行为是指独立所需的实际技能，被认为是唐氏综合症（DS）等伴有智力障碍的神经遗传性疾病儿童的优先干预目标。日常生活技能（DLS）是适应行为的一个重要方面，但它们很少受到干预措施的关注，这可能是因为它们涉及许多环境中的各种技能。本研究旨在通过考察 DLS 表现与被假设为支持 DLS 技能习得的认知技能--执行功能（EF）--之间的并发和纵向关联，推动 DLS 干预科学的发展：71名年龄在2.5至8.7岁之间的DS儿童（中=5.23岁；标准差=1.65）完成了一系列经过调整的执行功能任务，他们的主要照顾者完成了维尼兰适应行为量表第三版家长/照顾者综合报告表。一部分照顾者还提供了 6 个月和 12 个月的适应行为跟踪信息：结果表明，在同时和纵向上，EF 任务表现与 DLS 标准分数和 v 分数之间存在正相关：这些研究结果对未来潜在的干预方法具有启示意义，这些干预方法旨在通过提高该人群的EF技能来加强DLS表现。

{"title":"Laboratory-based measures of executive function and daily living skills in young children with Down syndrome: informing future interventions","authors":"K. Van Deusen, M. A. Prince, M. M. Walsh, A. J. Esbensen, L. R. Patel, M. E. Pinks, A. J. Thurman, L. Abbeduto, L. A. Daunhauer, D. J. Fidler","doi":"10.1111/jir.13176","DOIUrl":"10.1111/jir.13176","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Adaptive behaviour refers to the practical skills necessary for independence and is considered a high-priority intervention target for children with neurogenetic conditions associated with intellectual disability, like Down syndrome (DS). Daily living skills (DLS) are a critical aspect of adaptive behaviour, but they have received little intervention attention, possibly because they involve a wide variety of skills across many settings. The present study aimed to advance DLS intervention science by examining the concurrent and longitudinal association between DLS performances and a cognitive skillset hypothesised to support DLS skill acquisition, executive function (EF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants were 71 children with DS between the ages of 2.5 and 8.7 years (M = 5.23 years; standard deviation = 1.65) who completed a battery of adapted EF tasks and a primary caregiver who completed the Vineland Adaptive Behavior Scales 3rd Edition Parent/Caregiver Comprehensive Report Form. A subset of caregivers also provided 6- and 12-month follow-up adaptive behaviour information.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results demonstrated a positive association between EF task performance and DLS standard scores and <i>v</i>-scores both concurrently and longitudinally.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings have implications for potential future intervention approaches that aim to strengthen DLS performances by advancing EF skills in this population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16163,"journal":{"name":"Journal of Intellectual Disability Research","volume":"68 11","pages":"1301-1315"},"PeriodicalIF":2.1,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jir.13176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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