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Correlation Between MicroRNA by Extracellular Vesicle Mediated and Antiviral Effects of Interferon Omega in Feline Peripheral Blood. 猫外周血中细胞外囊泡介导的微RNA与Ω干扰素的抗病毒作用之间的相关性
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-01 DOI: 10.1089/jir.2023.0174
Mingxing Yang, Guowei Xu, Jingyan Zhang, Zhiting Guo, Chao Liang, Yajun Li, Lei Wang, Yuxia Zhou, Yi Ru, Jianxi Li, Xuezhi Wang, Yan Sun

Feline interferon omega (IFN-ω) has been proven to have high antiviral activity; however, its in-depth antiviral effects remain unknown. Extracellular vesicles (EVs) have been demonstrated to participate in the regulation of the immune response pathway for the body through various active substances, especially through the microRNA (miRNA) carried by them. In this study, we isolated EVs from feline peripheral blood by differential centrifugation, and further found that the content of IFN-ω in EVs increased continuously within 24 h after IFN-ω treatment, and a large number of miRNAs were significantly downregulated in EVs within 12 h after IFN-ω treatment. These significantly differentially expressed miRNAs were important for regulating changes in antiviral cytokines. This study reveals for the first time the correlation between EVs-mediated miRNA in feline peripheral blood and IFN-ω on antiviral immune response, which may provide strong data support for the development of novel antiviral nanomedicine and the research of the antiviral effects of IFN-ω.

猫干扰素ω(IFN-ω)已被证实具有很高的抗病毒活性,但其深层次的抗病毒作用仍不为人知。细胞外囊泡(EVs)已被证实可通过各种活性物质,特别是通过其携带的微RNA(miRNA)参与机体免疫应答途径的调节。本研究采用差速离心法从猫外周血中分离出EVs,进一步发现IFN-ω处理后24小时内EVs中IFN-ω的含量持续增加,IFN-ω处理后12小时内EVs中大量miRNA显著下调。这些明显差异表达的 miRNA 对调节抗病毒细胞因子的变化非常重要。本研究首次揭示了猫外周血中EVs介导的miRNA与IFN-ω对抗病毒免疫应答的相关性,为开发新型抗病毒纳米药物和研究IFN-ω的抗病毒作用提供了有力的数据支持。
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引用次数: 0
Cytokine Plasma Levels in Breast Cancer Patients, Before and After Surgery. 乳腺癌患者手术前后的细胞因子血浆水平
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI: 10.1089/jir.2023.0157
Emmanuel Kontomanolis, Christina Tsigalou, Achilleas Mitrakas, Anastasia G Gkegka, Eleni Efraimidou, Dimitrios Karamanidis, Konstantinos Nikoletos, Tsikouras Panagiotis, Nikolaos Nikoletos, Alexandra Giatromanolaki, Michael I Koukourakis

Studying the levels of cytokines in the plasma of patients could be valuable in guiding immunotherapy policies. We assessed the plasma levels of 4 major cytokines [interferon (IFN)-β, interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β)] collected from 19 patients with ductal breast cancer (BCa), before surgery (BS) and 5 days after surgery (AS). The ratio AS/BS was also calculated and correlated with histopathological variables and tumor-infiltrating lymphocyte (TIL) density. The IFN-β and TNF-α levels were significantly higher in BCa patients, BS and AS, than healthy controls (P < 0.02). High IL-2 levels BS were linked with node involvement (P = 0.02), and marginally with HER2 expression (P = 0.08), while high TNF-α levels were linked with high PgR expression (P = 0.02). Increasing IFN-β, IL-2, and TNF-α levels were noted AS, which was more evident in patients with larger tumors. The TGF-β levels were significantly lower in BCa patients (P < 0.007). Linear regression analysis showed a direct association of IFN-β levels AS (P = 0.02, r = 0.52) and of TNF-α AS/BS-ratio (P = 0.001, r = 0.72) with TIL-density. It is suggested that although effector immune response is evident in the majority of early stage BCa patients, removal of the primary tumor further unblocks such responses.

研究患者血浆中的细胞因子水平对指导免疫疗法政策很有价值。我们评估了 19 位导管型乳腺癌(BCa)患者手术前(BS)和手术后 5 天(AS)血浆中 4 种主要细胞因子[干扰素 (IFN)-β、白细胞介素-2 (IL-2)、肿瘤坏死因子α (TNF-α)、转化生长因子β (TGF-β)]的水平。此外,还计算了 AS/BS 比率,并将其与组织病理学变量和肿瘤浸润淋巴细胞(TIL)密度相关联。BCa患者(BS和AS)的IFN-β和TNF-α水平明显高于健康对照组(P = 0.02),与HER2表达略有关联(P = 0.08),而高TNF-α水平与高PgR表达有关(P = 0.02)。AS患者的IFN-β、IL-2和TNF-α水平不断升高,这在肿瘤较大的患者中更为明显。TGF-β水平在BCa患者中明显较低(P P = 0.02,r = 0.52),TNF-α的AS/BS比值(P = 0.001,r = 0.72)与TIL密度相关。这表明,虽然大多数早期 BCa 患者的效应免疫反应是明显的,但切除原发肿瘤会进一步解除这种反应。
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引用次数: 0
Molecular Insights of Nonalcoholic Fatty Liver Disease Pathogenesis. 非酒精性脂肪肝发病机制的分子洞察。
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-03-01 Epub Date: 2024-02-01 DOI: 10.1089/jir.2023.0162
Reham Mohammed Dawood, Ghada Maher Salum, Mai Abd El-Meguid, Basma El-Sayed Fotouh

Nonalcoholic fatty liver disease (NAFLD) is now the most prevalent chronic liver disease. Many hepatic abnormalities are associated with NAFLD such as nonalcoholic steatohepatitis, progressive fibrosis, cirrhosis, and liver failure. Moreover, the pathogenesis of NAFLD has numerous etiologies and can be explained due to the existence of several of stimulus that act simultaneously on genetically susceptible patients. These stimuli include obesity, diabetes, and insulin resistance. In addition, identifying the role of gut microbiota on NAFLD progression has been illustrated. In this review, we clarified the several factors that lead to the development of NAFLD and identify those who are most at risk of developing liver end-stage disease. Highlighting the noninvasive diagnostic NAFLD markers could be helpful in the disease prevention and treatment approaches.

非酒精性脂肪肝(NAFLD)是目前最普遍的慢性肝病。许多肝功能异常都与非酒精性脂肪肝有关,如非酒精性脂肪性肝炎、进行性纤维化、肝硬化和肝功能衰竭。此外,非酒精性脂肪肝的发病机制有多种病因,可以解释为存在多种刺激因素,同时作用于遗传易感患者。这些刺激因素包括肥胖、糖尿病和胰岛素抵抗。此外,肠道微生物群对非酒精性脂肪肝进展的作用也得到了证实。在这篇综述中,我们阐明了导致非酒精性脂肪肝发展的几个因素,并确定了哪些人最有可能发展成肝脏终末期疾病。强调非侵入性非酒精性脂肪肝诊断标志物有助于疾病的预防和治疗。
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引用次数: 0
Association of Polymorphisms of the IL-17A and IL-17F Genes with Increased Risk of Hypertension and Obesity in Mexican Patients with COVID-19. IL-17A和IL-17F基因多态性与墨西哥 COVID-19 患者高血压和肥胖症风险增加的关系。
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-02-01 Epub Date: 2023-12-28 DOI: 10.1089/jir.2023.0101
Richard Salama-Frisbie, Cinthia A Molina-Flores, Arguiñe I Urraza-Robledo, María E Gutiérrez-Pérez, Alberto A Miranda-Pérez, Alhi A Gutiérrez-Salas, Jorge Haro-Santa Cruz, Francisco C López-Márquez

Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2). COVID-19 can cause a cytokine release syndrome in which cytokines, including interleukin 17 (IL-17), are massively secreted in response to a specific stimulus. This can contribute to mortality and severe forms of COVID-19. The study aimed to determine the association of SARS-CoV2 infection with the IL-17A rs2275913 and IL-17F rs763780 variants, as well as with the associated comorbidities in COVID-19-positive Mexican patients. The study included 178 patients positive to COVID-19 and 177 COVID-19 negative subjects. For genotyping, the samples were amplified with a TaqMan® probe. There was no association between the AA genotype and A allele of IL-17A variant or the IL-17F C allele with the presence of COVID-19. In regard to comorbidities, a statistically significant association was found between IL-17A rs2275913 AA genotype and hypertension, as well as with the presence of obesity (P = 0.003, OR 23, 95% CI: 2.97-178.092 and P = 0.025, OR 28, 95% CI: 1.52-178.029, respectively) in patients with COVID-19. In conclusion, rs2275913 IL-17A polymorphism in COVID-19 patients seems to confer a higher susceptibility to the presence of hypertension and obesity, increasing the risk of premature cardiovascular disease in this population. However, more studies should be conducted for a better understanding of their relation.

冠状病毒病 2019(COVID-19)是由严重急性呼吸系统综合征冠状病毒-2(SARS-CoV2)引起的。COVID-19 可导致细胞因子释放综合征,即细胞因子(包括白细胞介素 17 (IL-17))在特定刺激下大量分泌。这可能导致死亡和严重的 COVID-19。该研究旨在确定 SARS-CoV2 感染与 IL-17A rs2275913 和 IL-17F rs763780 变体的关系,以及 COVID-19 阳性的墨西哥患者的相关合并症。该研究包括 178 名 COVID-19 阳性患者和 177 名 COVID-19 阴性受试者。在进行基因分型时,使用 TaqMan® 探针对样本进行扩增。IL-17A变体的AA基因型和A等位基因或IL-17F的C等位基因与COVID-19的存在没有关联。在合并症方面,在 COVID-19 患者中,IL-17A rs2275913 AA 基因型与高血压以及肥胖(分别为 P = 0.003,OR 23,95% CI:2.97-178.092 和 P = 0.025,OR 28,95% CI:1.52-178.029)之间存在统计学意义上的显著关联。总之,COVID-19 患者的 rs2275913 IL-17A 多态性似乎更容易导致高血压和肥胖,从而增加该人群过早罹患心血管疾病的风险。然而,要更好地了解它们之间的关系,还需要进行更多的研究。
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引用次数: 0
Cytokines 2023: 11th Annual Meeting of the International Cytokine and Interferon Society. 细胞因子 2023:国际细胞因子和干扰素学会第 11 届年会。
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-02-01 Epub Date: 2024-01-29 DOI: 10.1089/jir.2023.0207
Mary McCabe
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引用次数: 0
Interleukin-6 Family of Cytokines in Cancers. 癌症中的白细胞介素-6 家族细胞因子
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-02-01 Epub Date: 2024-01-17 DOI: 10.1089/jir.2023.0103
Iwona Zaporowska-Stachowiak, Michał Springer, Katarzyna Stachowiak, Mary Oduah, Maciej Sopata, Katarzyna Wieczorowska-Tobis, Wiesław Bryl

Nine soluble ligands [interleukin-6 (IL-6), interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, interleukin-27 (IL-27), and interleukin-31] share the ubiquitously expressed transmembrane protein-glycoprotein-130 beta-subunit (gp130) and thus form IL-6 family cytokines. Proteins that may be important for cancerogenesis, CT-1, IL-11, IL-27, LIF, OSM, and CNTF, belong to the superfamily of IL-6. Cytokines such as IL-6, IL-11, and IL-27 are better investigated in comparison with other members of the same family of cytokines, eg, CT-1. Gp130 is one of the main receptors through which these cytokines exert their effects. The clinical implication of understanding the pathways of these cytokines in oncology is that targeted therapy to inhibit or potentiate cytokine activity may lead to remission in some cases.

九种可溶性配体[白细胞介素-6 (IL-6)、白细胞介素-11 (IL-11)、白血病抑制因子 (LIF)、鹅肌肽 M (OSM)、睫状肌神经营养因子 (CNTF)、心脏营养素-1 (CT-1)、白细胞介素-27(IL-27)和白细胞介素-31]共享普遍表达的跨膜蛋白-糖蛋白-130 beta-亚基(gp130),因此形成 IL-6 家族细胞因子。可能对癌症发生有重要影响的蛋白质 CT-1、IL-11、IL-27、LIF、OSM 和 CNTF 都属于 IL-6 的超家族。IL-6、IL-11 和 IL-27 等细胞因子与 CT-1 等同属一个细胞因子家族的其他成员相比,得到了更好的研究。Gp130 是这些细胞因子发挥作用的主要受体之一。了解这些细胞因子在肿瘤学中的作用途径的临床意义在于,抑制或增强细胞因子活性的靶向治疗可能会使某些病例的病情得到缓解。
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引用次数: 0
C-C Motif Chemokine 2 Regulates Macrophage Polarization and Contributes to Myocardial Infarction Healing. C-C Motif趋化因子2调控巨噬细胞极化并促进心肌梗死愈合
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-02-01 Epub Date: 2023-12-28 DOI: 10.1089/jir.2023.0132
Liangwei Chen, Dihao Pan, Yiran Zhang, Enfan Zhang, Liang Ma

Macrophages are crucial immune cells that play essential roles in the healing of myocardial infarction (MI), undergoing continuous polarization throughout this process. C-C motif chemokine 2 (CCL2) is a chemokine that regulates inflammatory responses during MI. However, the extent to which CCL2 influences macrophage polarization and MI healing remains incompletely understood. In this study, we investigate the role of CCL2 in macrophage polarization and MI healing. Our findings reveal that CCL2 is differentially expressed in lipopolysaccharide (LPS)-induced M1 and interleukin (IL)-4-induced M2 RAW264.7 macrophages. Knockdown of CCL2 attenuates TNF-α secretion stimulated by LPS, while overexpression of CCL2 mitigates IL-10 production triggered by IL-4 in these macrophages. Moreover, CCL2 deficiency disrupts LPS-induced M1 polarization, whereas CCL2 overexpression reduces M2 polarization of RAW264.7 macrophages induced by IL-4. Further exploration indicates that the promotion of M1 polarization by CCL2 is significantly impaired by inhibition of the p38-mediated MAPK pathway and NF-κB pathway. In a MI mouse model, CCL2 knockdown remarkably reduces infarct size, collagen synthesis, and the expression of cardiac fibrosis and hypertrophy markers. The activity of the p38-mediated MAPK pathway and NF-κB pathway is downregulated by CCL2 knockdown as well. Additionally, the number of total macrophages and M1 macrophages in the infarct decreases, while the number of M2 macrophages increases upon CCL2 deficiency. In conclusion, these results suggest that CCL2 is a key regulator of macrophage polarization, controlling MI healing in vivo.

巨噬细胞是重要的免疫细胞,在心肌梗塞(MI)愈合过程中发挥着至关重要的作用,并在整个过程中不断分化。C-C motif趋化因子2(CCL2)是一种趋化因子,可调节心肌梗死过程中的炎症反应。然而,CCL2 对巨噬细胞极化和心肌梗死愈合的影响程度仍不完全清楚。在本研究中,我们探讨了 CCL2 在巨噬细胞极化和 MI 愈合中的作用。我们的研究结果表明,CCL2在脂多糖(LPS)诱导的M1和白细胞介素(IL)-4诱导的M2 RAW264.7巨噬细胞中表达不同。敲除 CCL2 可减轻 LPS 刺激的 TNF-α 分泌,而过表达 CCL2 则可减轻 IL-4 在这些巨噬细胞中引发的 IL-10 的产生。此外,缺乏 CCL2 会破坏 LPS 诱导的 M1 极化,而过表达 CCL2 则会降低 IL-4 诱导的 RAW264.7 巨噬细胞的 M2 极化。进一步的研究表明,抑制 p38 介导的 MAPK 通路和 NF-κB 通路会显著削弱 CCL2 对 M1 极化的促进作用。在心肌梗死小鼠模型中,CCL2 的敲除可显著缩小梗死面积、减少胶原合成、降低心脏纤维化和肥大标志物的表达。CCL2 基因敲除还能降低 p38 介导的 MAPK 通路和 NF-κB 通路的活性。此外,CCL2 缺乏时,梗死区总巨噬细胞和 M1 巨噬细胞的数量减少,而 M2 巨噬细胞的数量增加。总之,这些结果表明,CCL2 是巨噬细胞极化的关键调节因子,控制着体内 MI 的愈合。
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引用次数: 0
Levels of Cytokines in Leptospirosis Patients with Different Serovars and rfb Locus. 不同血清型和 rfb 基因座的钩端螺旋体病患者体内的细胞因子水平
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-02-01 DOI: 10.1089/jir.2023.0091
Indika Senavirathna, Dinesha Jayasundara, Janith Warnasekara, Chamila Kappagoda, Suneth Agampodi

Leptospirosis has a wide spectrum of clinical manifestations ranging from mild to severe disease. The cytokine response is considered one of the key drivers for this varying manifestation. The different cytokine response observed in patients with leptospirosis could be due to the variation of infecting serovars. Since the rfb locus codes for the lipopolysaccharide synthesis of the bacterial cell wall, which also determines the serovar, this locus may play a role in driving a specific cytokine response in the host. We investigated 12 commonly used cytokine profiles in serum samples of culture, microscopic agglutination test (MAT), or polymerase chain reaction (PCR)-positive patients with leptospirosis. The sequences of the rfb locus in culture-positive samples were generated from whole genome sequencing and serovar status was drawn from original data published. Isolated cultures were subjected to whole genome sequencing using the PacBio RS II system, and the resulting data were used to determine the species. The recovered genomic data were annotated with the Rapid Annotation using Subsystem Technology (RAST) subsystem, and the rfb locus was extracted. The cytokine analysis was carried out using the Qiagen human ELISA kit. Eighteen samples were found to be positive by culture, while the other 7 samples were positive by PCR or MAT. Infections from Leptospira interrogans serovar Autumnalis (5), Pyrogens (3), Icterohaemorrhagiae (1) Leptospira borgpetersenii (all 7 samples clustered in same clonal group with serovar status not determined), Leptospira weilii (1 with serovar status not determined), and Leptospira kirschneri serovar Grippotyphosa (1) were included in the analysis. Three patients [infected with Leptospira interrogansserovar Autumnalis (2) and Pyrogens (1)] and 2 MAT-positive patients (highest titer against serovar Bratislava of L.interrognas) were reported to have severe clinical manifestations, while the rest had mild to moderate symptoms. Although the serum cytokine concentration of patients with severe clinical manifestation was comparatively higher, a statistically significant difference was observed only for interleukin (IL)-1β (P < 0.05). IL-10/tumor necrosis factor-alpha (TNF-α) ratio was high in patients with severe complications. In general, patients infected with L. interrogans showed higher concentration of cytokines compared to L. borgpetersenii.

钩端螺旋体病的临床表现范围很广,从轻微到严重不等。细胞因子反应被认为是导致这种不同表现的关键因素之一。在钩端螺旋体病患者身上观察到的不同细胞因子反应可能是由于感染的血清型不同造成的。由于 rfb 基因座编码细菌细胞壁脂多糖的合成,这也决定了血清型,因此该基因座可能在驱动宿主的特定细胞因子反应中发挥作用。我们研究了培养、显微凝集试验(MAT)或聚合酶链反应(PCR)阳性钩端螺旋体病患者血清样本中的 12 种常用细胞因子谱。培养阳性样本中 rfb 基因座的序列来自全基因组测序,血清型状态来自已发表的原始数据。使用 PacBio RS II 系统对分离培养物进行全基因组测序,并根据测序结果确定物种。利用子系统技术快速注释(RAST)子系统对恢复的基因组数据进行注释,并提取 rfb 基因座。细胞因子分析使用 Qiagen 人类 ELISA 试剂盒进行。通过培养发现 18 个样本呈阳性,另外 7 个样本通过 PCR 或 MAT 呈阳性。分析中包括的感染病原体有:审讯钩端螺旋体(Leptospira interrogans serovar Autumnalis)(5 例)、Pyrogens(3 例)、Icterohaemorrhagiae(1 例)、Leptospira borgpetersenii(所有 7 例样本均聚集在同一克隆组,血清型尚未确定)、Leptospira weilii(1 例,血清型尚未确定)和 Leptospira kirschneri serovar Grippotyphosa(1 例)。据报告,3 名患者(感染了 Leptospira interrogansserovar Autumnalis (2) 和 Pyrogens (1))和 2 名 MAT 阳性患者(对 L.interrognas 的血清菌株 Bratislava 的滴度最高)有严重的临床表现,其余患者的症状为轻度至中度。虽然临床表现严重的患者血清细胞因子浓度相对较高,但只有白细胞介素(IL)-1β(P. L. interrogans 的细胞因子浓度高于 L. borgpetersenii)有显著统计学差异。
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引用次数: 0
Analysis of Interleukin-6 Gene Variants (rs1800795, rs1800796, rs1554606, rs1800797, rs2069840, rs12700386, and rs2069861) as Prognostic Markers in Breast Cancer: A Systematic Review, Meta-Analysis, and Network Analysis. 白介素-6基因变异(rs1800795、rs1800796、rs1554606、rs1800797、rs2069840、rs12700386和rs2069861)作为乳腺癌预后标志物的分析:系统综述、meta分析和网络分析
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-01-01 Epub Date: 2023-11-29 DOI: 10.1089/jir.2023.0090
Ali Azizi, Nasrin Mansouri, Mitra Tarlan, Masoud Sadeghi

Interleukin-6 (IL-6) has obviously tumor-promoting and tumor-inhibitory effects and can induce an epithelial-mesenchymal transition phenotype in human breast cancer (BC) cells and implicate its potential to promote BC metastasis. Herein, we aimed to evaluate the association of IL-6 variants (rs1800795, rs1800796, rs1554606, rs1800797, rs2069840, rs12700386, and rs2069861) with the susceptibility to BC. The databases of PubMed/Medline, Web of Science, Scopus, and Cochrane Library were searched until December 19, 2022, without any restrictions. The quality assessment of each study was performed based on the Newcastle-Ottawa Scale tool. The Review Manager 5.3 software presented the effect sizes including odds ratio (OR) along with a 95% confidence interval (CI). Both publication bias and sensitivity analyses were carried out by the Comprehensive Meta-Analysis version 2.0 software. A total of 2,508 records were identified among databases and at last, 27 articles were entered into the meta-analysis. Seven polymorphisms of IL-6 were entered into the analyses. Just rs1800797 polymorphism in the dominant model (OR = 1.51; 95% CI = 1.15-2.00; P = 0.003) and rs2069840 polymorphism in heterozygous (OR = 0.89; 95% CI = 0.81-0.97; P = 0.008) and dominant (OR = 0.91; 95% CI = 0.84-0.99; P = 0.02) models had a significant association with the BC risk. In conclusion, among 7 polymorphisms and despite a few included cases, the present meta-analysis recommended that the AA+GA genotype of rs1800797 polymorphism had a significantly elevated risk and the GC and the CC+GC genotypes of rs2069840 polymorphism had a protective role in the BC patients.

白细胞介素-6 (IL-6)具有明显的促瘤和抑瘤作用,可诱导人乳腺癌细胞上皮-间质转化表型,并可能促进乳腺癌转移。在此,我们旨在评估IL-6变异(rs1800795、rs1800796、rs1554606、rs1800797、rs2069840、rs12700386和rs2069861)与BC易感性的关系。检索PubMed/Medline、Web of Science、Scopus、Cochrane Library等数据库至2022年12月19日,无任何限制。每个研究的质量评估是基于纽卡斯尔-渥太华量表工具进行的。Review Manager 5.3软件显示了包括优势比(OR)和95%置信区间(CI)在内的效应大小。发表偏倚和敏感性分析均采用综合meta分析2.0版软件进行。在数据库中共识别2508条记录,最终有27篇文章被纳入meta分析。IL-6的7个多态性被纳入分析。优势模型只有rs1800797多态性(OR = 1.51;95% ci = 1.15-2.00;P = 0.003),杂合子rs2069840多态性(OR = 0.89;95% ci = 0.81-0.97;P = 0.008)和显性(OR = 0.91;95% ci = 0.84-0.99;P = 0.02)模型与BC风险显著相关。综上所述,在7个多态性中,除了少数纳入病例外,本meta分析提示rs1800797多态性的AA+GA基因型在BC患者中具有显著升高的风险,rs2069840多态性的GC和CC+GC基因型在BC患者中具有保护作用。
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引用次数: 0
The "Yin-Yang" Activities of Tumor-Induced Inflammatory Cytokines for Cancer Immunotherapy, Detection, and Prognosis. 肿瘤诱导的炎性细胞因子的 "阴阳 "活动对癌症免疫疗法、检测和预后的影响。
IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Pub Date : 2024-01-01 Epub Date: 2023-12-29 DOI: 10.1089/jir.2023.29058.editorial
Yan Ma
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引用次数: 0
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Journal of Interferon and Cytokine Research
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