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Association of Polymorphisms of the IL-17A and IL-17F Genes with Increased Risk of Hypertension and Obesity in Mexican Patients with COVID-19. IL-17A和IL-17F基因多态性与墨西哥 COVID-19 患者高血压和肥胖症风险增加的关系。
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-02-01 Epub Date: 2023-12-28 DOI: 10.1089/jir.2023.0101
Richard Salama-Frisbie, Cinthia A Molina-Flores, Arguiñe I Urraza-Robledo, María E Gutiérrez-Pérez, Alberto A Miranda-Pérez, Alhi A Gutiérrez-Salas, Jorge Haro-Santa Cruz, Francisco C López-Márquez

Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV2). COVID-19 can cause a cytokine release syndrome in which cytokines, including interleukin 17 (IL-17), are massively secreted in response to a specific stimulus. This can contribute to mortality and severe forms of COVID-19. The study aimed to determine the association of SARS-CoV2 infection with the IL-17A rs2275913 and IL-17F rs763780 variants, as well as with the associated comorbidities in COVID-19-positive Mexican patients. The study included 178 patients positive to COVID-19 and 177 COVID-19 negative subjects. For genotyping, the samples were amplified with a TaqMan® probe. There was no association between the AA genotype and A allele of IL-17A variant or the IL-17F C allele with the presence of COVID-19. In regard to comorbidities, a statistically significant association was found between IL-17A rs2275913 AA genotype and hypertension, as well as with the presence of obesity (P = 0.003, OR 23, 95% CI: 2.97-178.092 and P = 0.025, OR 28, 95% CI: 1.52-178.029, respectively) in patients with COVID-19. In conclusion, rs2275913 IL-17A polymorphism in COVID-19 patients seems to confer a higher susceptibility to the presence of hypertension and obesity, increasing the risk of premature cardiovascular disease in this population. However, more studies should be conducted for a better understanding of their relation.

冠状病毒病 2019(COVID-19)是由严重急性呼吸系统综合征冠状病毒-2(SARS-CoV2)引起的。COVID-19 可导致细胞因子释放综合征,即细胞因子(包括白细胞介素 17 (IL-17))在特定刺激下大量分泌。这可能导致死亡和严重的 COVID-19。该研究旨在确定 SARS-CoV2 感染与 IL-17A rs2275913 和 IL-17F rs763780 变体的关系,以及 COVID-19 阳性的墨西哥患者的相关合并症。该研究包括 178 名 COVID-19 阳性患者和 177 名 COVID-19 阴性受试者。在进行基因分型时,使用 TaqMan® 探针对样本进行扩增。IL-17A变体的AA基因型和A等位基因或IL-17F的C等位基因与COVID-19的存在没有关联。在合并症方面,在 COVID-19 患者中,IL-17A rs2275913 AA 基因型与高血压以及肥胖(分别为 P = 0.003,OR 23,95% CI:2.97-178.092 和 P = 0.025,OR 28,95% CI:1.52-178.029)之间存在统计学意义上的显著关联。总之,COVID-19 患者的 rs2275913 IL-17A 多态性似乎更容易导致高血压和肥胖,从而增加该人群过早罹患心血管疾病的风险。然而,要更好地了解它们之间的关系,还需要进行更多的研究。
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引用次数: 0
Cytokines 2023: 11th Annual Meeting of the International Cytokine and Interferon Society. 细胞因子 2023:国际细胞因子和干扰素学会第 11 届年会。
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-02-01 Epub Date: 2024-01-29 DOI: 10.1089/jir.2023.0207
Mary McCabe
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引用次数: 0
Interleukin-6 Family of Cytokines in Cancers. 癌症中的白细胞介素-6 家族细胞因子
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-02-01 Epub Date: 2024-01-17 DOI: 10.1089/jir.2023.0103
Iwona Zaporowska-Stachowiak, Michał Springer, Katarzyna Stachowiak, Mary Oduah, Maciej Sopata, Katarzyna Wieczorowska-Tobis, Wiesław Bryl

Nine soluble ligands [interleukin-6 (IL-6), interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine, interleukin-27 (IL-27), and interleukin-31] share the ubiquitously expressed transmembrane protein-glycoprotein-130 beta-subunit (gp130) and thus form IL-6 family cytokines. Proteins that may be important for cancerogenesis, CT-1, IL-11, IL-27, LIF, OSM, and CNTF, belong to the superfamily of IL-6. Cytokines such as IL-6, IL-11, and IL-27 are better investigated in comparison with other members of the same family of cytokines, eg, CT-1. Gp130 is one of the main receptors through which these cytokines exert their effects. The clinical implication of understanding the pathways of these cytokines in oncology is that targeted therapy to inhibit or potentiate cytokine activity may lead to remission in some cases.

九种可溶性配体[白细胞介素-6 (IL-6)、白细胞介素-11 (IL-11)、白血病抑制因子 (LIF)、鹅肌肽 M (OSM)、睫状肌神经营养因子 (CNTF)、心脏营养素-1 (CT-1)、白细胞介素-27(IL-27)和白细胞介素-31]共享普遍表达的跨膜蛋白-糖蛋白-130 beta-亚基(gp130),因此形成 IL-6 家族细胞因子。可能对癌症发生有重要影响的蛋白质 CT-1、IL-11、IL-27、LIF、OSM 和 CNTF 都属于 IL-6 的超家族。IL-6、IL-11 和 IL-27 等细胞因子与 CT-1 等同属一个细胞因子家族的其他成员相比,得到了更好的研究。Gp130 是这些细胞因子发挥作用的主要受体之一。了解这些细胞因子在肿瘤学中的作用途径的临床意义在于,抑制或增强细胞因子活性的靶向治疗可能会使某些病例的病情得到缓解。
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引用次数: 0
C-C Motif Chemokine 2 Regulates Macrophage Polarization and Contributes to Myocardial Infarction Healing. C-C Motif趋化因子2调控巨噬细胞极化并促进心肌梗死愈合
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-02-01 Epub Date: 2023-12-28 DOI: 10.1089/jir.2023.0132
Liangwei Chen, Dihao Pan, Yiran Zhang, Enfan Zhang, Liang Ma

Macrophages are crucial immune cells that play essential roles in the healing of myocardial infarction (MI), undergoing continuous polarization throughout this process. C-C motif chemokine 2 (CCL2) is a chemokine that regulates inflammatory responses during MI. However, the extent to which CCL2 influences macrophage polarization and MI healing remains incompletely understood. In this study, we investigate the role of CCL2 in macrophage polarization and MI healing. Our findings reveal that CCL2 is differentially expressed in lipopolysaccharide (LPS)-induced M1 and interleukin (IL)-4-induced M2 RAW264.7 macrophages. Knockdown of CCL2 attenuates TNF-α secretion stimulated by LPS, while overexpression of CCL2 mitigates IL-10 production triggered by IL-4 in these macrophages. Moreover, CCL2 deficiency disrupts LPS-induced M1 polarization, whereas CCL2 overexpression reduces M2 polarization of RAW264.7 macrophages induced by IL-4. Further exploration indicates that the promotion of M1 polarization by CCL2 is significantly impaired by inhibition of the p38-mediated MAPK pathway and NF-κB pathway. In a MI mouse model, CCL2 knockdown remarkably reduces infarct size, collagen synthesis, and the expression of cardiac fibrosis and hypertrophy markers. The activity of the p38-mediated MAPK pathway and NF-κB pathway is downregulated by CCL2 knockdown as well. Additionally, the number of total macrophages and M1 macrophages in the infarct decreases, while the number of M2 macrophages increases upon CCL2 deficiency. In conclusion, these results suggest that CCL2 is a key regulator of macrophage polarization, controlling MI healing in vivo.

巨噬细胞是重要的免疫细胞,在心肌梗塞(MI)愈合过程中发挥着至关重要的作用,并在整个过程中不断分化。C-C motif趋化因子2(CCL2)是一种趋化因子,可调节心肌梗死过程中的炎症反应。然而,CCL2 对巨噬细胞极化和心肌梗死愈合的影响程度仍不完全清楚。在本研究中,我们探讨了 CCL2 在巨噬细胞极化和 MI 愈合中的作用。我们的研究结果表明,CCL2在脂多糖(LPS)诱导的M1和白细胞介素(IL)-4诱导的M2 RAW264.7巨噬细胞中表达不同。敲除 CCL2 可减轻 LPS 刺激的 TNF-α 分泌,而过表达 CCL2 则可减轻 IL-4 在这些巨噬细胞中引发的 IL-10 的产生。此外,缺乏 CCL2 会破坏 LPS 诱导的 M1 极化,而过表达 CCL2 则会降低 IL-4 诱导的 RAW264.7 巨噬细胞的 M2 极化。进一步的研究表明,抑制 p38 介导的 MAPK 通路和 NF-κB 通路会显著削弱 CCL2 对 M1 极化的促进作用。在心肌梗死小鼠模型中,CCL2 的敲除可显著缩小梗死面积、减少胶原合成、降低心脏纤维化和肥大标志物的表达。CCL2 基因敲除还能降低 p38 介导的 MAPK 通路和 NF-κB 通路的活性。此外,CCL2 缺乏时,梗死区总巨噬细胞和 M1 巨噬细胞的数量减少,而 M2 巨噬细胞的数量增加。总之,这些结果表明,CCL2 是巨噬细胞极化的关键调节因子,控制着体内 MI 的愈合。
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引用次数: 0
Levels of Cytokines in Leptospirosis Patients with Different Serovars and rfb Locus. 不同血清型和 rfb 基因座的钩端螺旋体病患者体内的细胞因子水平
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-02-01 DOI: 10.1089/jir.2023.0091
Indika Senavirathna, Dinesha Jayasundara, Janith Warnasekara, Chamila Kappagoda, Suneth Agampodi

Leptospirosis has a wide spectrum of clinical manifestations ranging from mild to severe disease. The cytokine response is considered one of the key drivers for this varying manifestation. The different cytokine response observed in patients with leptospirosis could be due to the variation of infecting serovars. Since the rfb locus codes for the lipopolysaccharide synthesis of the bacterial cell wall, which also determines the serovar, this locus may play a role in driving a specific cytokine response in the host. We investigated 12 commonly used cytokine profiles in serum samples of culture, microscopic agglutination test (MAT), or polymerase chain reaction (PCR)-positive patients with leptospirosis. The sequences of the rfb locus in culture-positive samples were generated from whole genome sequencing and serovar status was drawn from original data published. Isolated cultures were subjected to whole genome sequencing using the PacBio RS II system, and the resulting data were used to determine the species. The recovered genomic data were annotated with the Rapid Annotation using Subsystem Technology (RAST) subsystem, and the rfb locus was extracted. The cytokine analysis was carried out using the Qiagen human ELISA kit. Eighteen samples were found to be positive by culture, while the other 7 samples were positive by PCR or MAT. Infections from Leptospira interrogans serovar Autumnalis (5), Pyrogens (3), Icterohaemorrhagiae (1) Leptospira borgpetersenii (all 7 samples clustered in same clonal group with serovar status not determined), Leptospira weilii (1 with serovar status not determined), and Leptospira kirschneri serovar Grippotyphosa (1) were included in the analysis. Three patients [infected with Leptospira interrogansserovar Autumnalis (2) and Pyrogens (1)] and 2 MAT-positive patients (highest titer against serovar Bratislava of L.interrognas) were reported to have severe clinical manifestations, while the rest had mild to moderate symptoms. Although the serum cytokine concentration of patients with severe clinical manifestation was comparatively higher, a statistically significant difference was observed only for interleukin (IL)-1β (P < 0.05). IL-10/tumor necrosis factor-alpha (TNF-α) ratio was high in patients with severe complications. In general, patients infected with L. interrogans showed higher concentration of cytokines compared to L. borgpetersenii.

钩端螺旋体病的临床表现范围很广,从轻微到严重不等。细胞因子反应被认为是导致这种不同表现的关键因素之一。在钩端螺旋体病患者身上观察到的不同细胞因子反应可能是由于感染的血清型不同造成的。由于 rfb 基因座编码细菌细胞壁脂多糖的合成,这也决定了血清型,因此该基因座可能在驱动宿主的特定细胞因子反应中发挥作用。我们研究了培养、显微凝集试验(MAT)或聚合酶链反应(PCR)阳性钩端螺旋体病患者血清样本中的 12 种常用细胞因子谱。培养阳性样本中 rfb 基因座的序列来自全基因组测序,血清型状态来自已发表的原始数据。使用 PacBio RS II 系统对分离培养物进行全基因组测序,并根据测序结果确定物种。利用子系统技术快速注释(RAST)子系统对恢复的基因组数据进行注释,并提取 rfb 基因座。细胞因子分析使用 Qiagen 人类 ELISA 试剂盒进行。通过培养发现 18 个样本呈阳性,另外 7 个样本通过 PCR 或 MAT 呈阳性。分析中包括的感染病原体有:审讯钩端螺旋体(Leptospira interrogans serovar Autumnalis)(5 例)、Pyrogens(3 例)、Icterohaemorrhagiae(1 例)、Leptospira borgpetersenii(所有 7 例样本均聚集在同一克隆组,血清型尚未确定)、Leptospira weilii(1 例,血清型尚未确定)和 Leptospira kirschneri serovar Grippotyphosa(1 例)。据报告,3 名患者(感染了 Leptospira interrogansserovar Autumnalis (2) 和 Pyrogens (1))和 2 名 MAT 阳性患者(对 L.interrognas 的血清菌株 Bratislava 的滴度最高)有严重的临床表现,其余患者的症状为轻度至中度。虽然临床表现严重的患者血清细胞因子浓度相对较高,但只有白细胞介素(IL)-1β(P. L. interrogans 的细胞因子浓度高于 L. borgpetersenii)有显著统计学差异。
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引用次数: 0
Analysis of Interleukin-6 Gene Variants (rs1800795, rs1800796, rs1554606, rs1800797, rs2069840, rs12700386, and rs2069861) as Prognostic Markers in Breast Cancer: A Systematic Review, Meta-Analysis, and Network Analysis. 白介素-6基因变异(rs1800795、rs1800796、rs1554606、rs1800797、rs2069840、rs12700386和rs2069861)作为乳腺癌预后标志物的分析:系统综述、meta分析和网络分析
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-01-01 Epub Date: 2023-11-29 DOI: 10.1089/jir.2023.0090
Ali Azizi, Nasrin Mansouri, Mitra Tarlan, Masoud Sadeghi

Interleukin-6 (IL-6) has obviously tumor-promoting and tumor-inhibitory effects and can induce an epithelial-mesenchymal transition phenotype in human breast cancer (BC) cells and implicate its potential to promote BC metastasis. Herein, we aimed to evaluate the association of IL-6 variants (rs1800795, rs1800796, rs1554606, rs1800797, rs2069840, rs12700386, and rs2069861) with the susceptibility to BC. The databases of PubMed/Medline, Web of Science, Scopus, and Cochrane Library were searched until December 19, 2022, without any restrictions. The quality assessment of each study was performed based on the Newcastle-Ottawa Scale tool. The Review Manager 5.3 software presented the effect sizes including odds ratio (OR) along with a 95% confidence interval (CI). Both publication bias and sensitivity analyses were carried out by the Comprehensive Meta-Analysis version 2.0 software. A total of 2,508 records were identified among databases and at last, 27 articles were entered into the meta-analysis. Seven polymorphisms of IL-6 were entered into the analyses. Just rs1800797 polymorphism in the dominant model (OR = 1.51; 95% CI = 1.15-2.00; P = 0.003) and rs2069840 polymorphism in heterozygous (OR = 0.89; 95% CI = 0.81-0.97; P = 0.008) and dominant (OR = 0.91; 95% CI = 0.84-0.99; P = 0.02) models had a significant association with the BC risk. In conclusion, among 7 polymorphisms and despite a few included cases, the present meta-analysis recommended that the AA+GA genotype of rs1800797 polymorphism had a significantly elevated risk and the GC and the CC+GC genotypes of rs2069840 polymorphism had a protective role in the BC patients.

白细胞介素-6 (IL-6)具有明显的促瘤和抑瘤作用,可诱导人乳腺癌细胞上皮-间质转化表型,并可能促进乳腺癌转移。在此,我们旨在评估IL-6变异(rs1800795、rs1800796、rs1554606、rs1800797、rs2069840、rs12700386和rs2069861)与BC易感性的关系。检索PubMed/Medline、Web of Science、Scopus、Cochrane Library等数据库至2022年12月19日,无任何限制。每个研究的质量评估是基于纽卡斯尔-渥太华量表工具进行的。Review Manager 5.3软件显示了包括优势比(OR)和95%置信区间(CI)在内的效应大小。发表偏倚和敏感性分析均采用综合meta分析2.0版软件进行。在数据库中共识别2508条记录,最终有27篇文章被纳入meta分析。IL-6的7个多态性被纳入分析。优势模型只有rs1800797多态性(OR = 1.51;95% ci = 1.15-2.00;P = 0.003),杂合子rs2069840多态性(OR = 0.89;95% ci = 0.81-0.97;P = 0.008)和显性(OR = 0.91;95% ci = 0.84-0.99;P = 0.02)模型与BC风险显著相关。综上所述,在7个多态性中,除了少数纳入病例外,本meta分析提示rs1800797多态性的AA+GA基因型在BC患者中具有显著升高的风险,rs2069840多态性的GC和CC+GC基因型在BC患者中具有保护作用。
{"title":"Analysis of <i>Interleukin-6</i> Gene Variants (<i>rs1800795</i>, <i>rs1800796</i>, <i>rs1554606</i>, <i>rs1800797</i>, <i>rs2069840</i>, <i>rs12700386</i>, and <i>rs2069861</i>) as Prognostic Markers in Breast Cancer: A Systematic Review, Meta-Analysis, and Network Analysis.","authors":"Ali Azizi, Nasrin Mansouri, Mitra Tarlan, Masoud Sadeghi","doi":"10.1089/jir.2023.0090","DOIUrl":"10.1089/jir.2023.0090","url":null,"abstract":"<p><p>Interleukin-6 (IL-6) has obviously tumor-promoting and tumor-inhibitory effects and can induce an epithelial-mesenchymal transition phenotype in human breast cancer (BC) cells and implicate its potential to promote BC metastasis. Herein, we aimed to evaluate the association of <i>IL-6</i> variants (<i>rs1800795</i>, <i>rs1800796</i>, <i>rs1554606</i>, <i>rs1800797</i>, <i>rs2069840</i>, <i>rs12700386</i>, and <i>rs2069861</i>) with the susceptibility to BC. The databases of PubMed/Medline, Web of Science, Scopus, and Cochrane Library were searched until December 19, 2022, without any restrictions. The quality assessment of each study was performed based on the Newcastle-Ottawa Scale tool. The Review Manager 5.3 software presented the effect sizes including odds ratio (OR) along with a 95% confidence interval (CI). Both publication bias and sensitivity analyses were carried out by the Comprehensive Meta-Analysis version 2.0 software. A total of 2,508 records were identified among databases and at last, 27 articles were entered into the meta-analysis. Seven polymorphisms of IL-6 were entered into the analyses. Just <i>rs1800797</i> polymorphism in the dominant model (OR = 1.51; 95% CI = 1.15-2.00; <i>P</i> = 0.003) and <i>rs2069840</i> polymorphism in heterozygous (OR = 0.89; 95% CI = 0.81-0.97; <i>P</i> = 0.008) and dominant (OR = 0.91; 95% CI = 0.84-0.99; <i>P</i> = 0.02) models had a significant association with the BC risk. In conclusion, among 7 polymorphisms and despite a few included cases, the present meta-analysis recommended that the AA+GA genotype of <i>rs1800797</i> polymorphism had a significantly elevated risk and the GC and the CC+GC genotypes of <i>rs2069840</i> polymorphism had a protective role in the BC patients.</p>","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The "Yin-Yang" Activities of Tumor-Induced Inflammatory Cytokines for Cancer Immunotherapy, Detection, and Prognosis. 肿瘤诱导的炎性细胞因子的 "阴阳 "活动对癌症免疫疗法、检测和预后的影响。
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-01-01 Epub Date: 2023-12-29 DOI: 10.1089/jir.2023.29058.editorial
Yan Ma
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引用次数: 0
Impact of Chronic Moderate Exercise on Immune Cells and Cytokine Levels in Rats: Focus on the Endocannabinergic Pathway. 慢性适度运动对大鼠免疫细胞和细胞因子水平的影响:内源性大麻素途径的研究
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-01-01 Epub Date: 2023-11-14 DOI: 10.1089/jir.2023.0120
Salvador Valencia-Sánchez, Karen Elizabeth Nava-Castro, Claudia Angélica Garay-Canales, Víctor Hugo Del Río-Araiza, Jorge Morales-Montor

Although the modulation of immunity by exercise has been a long-studied paradigm, the molecular pathways connecting the two are still not fully understood. Regular moderate aerobic exercise is associated with improved health and directly impacts the immune system by changing the proportion of cell subpopulations, their function, and interleukin production. The endocannabinoid system has gained importance as an immune modulator, affected by moderate aerobic promoting the production of endocannabinoids, which are ligands of the cannabinoid receptors (CBRs) expressed on the surface of all immune cells. Our group previously reported a reduction of lymphocytic populations in the spleen of chronically exercised rats, accompanied by an increase in CBR expression. Given the complex and compartmentalized nature of the immune system, we decided to study the effects of chronic exercise on the proportion of peripheral blood mononuclear cells, serum interleukins, and the expression of CBRs on these cells. Overall, our results indicate that chronic exercise decreases the proportion of T helper and Tγδ cells but increases the expression of cannabinoids (CBR1) on T helper and natural killer cells, and the production of interleukins, including IL-1β, interferon-gamma, tumor necrosis factor-alpha, IL-10, and IL-4, suggesting higher reactivity and efficiency from the immune system conferred by exercise.

虽然运动对免疫的调节已经被研究了很长时间,但连接两者的分子途径仍然没有完全被理解。定期适度的有氧运动与改善健康有关,并通过改变细胞亚群的比例、功能和白细胞介素的产生直接影响免疫系统。内源性大麻素系统作为一种重要的免疫调节剂,受到适度有氧运动的影响,促进内源性大麻素的产生,内源性大麻素是在所有免疫细胞表面表达的大麻素受体(CBRs)的配体。本研究小组之前报道了长期运动大鼠脾脏淋巴细胞数量减少,并伴有CBR表达增加。鉴于免疫系统的复杂性和区隔性,我们决定研究慢性运动对外周血单个核细胞比例、血清白细胞介素和这些细胞上cbr表达的影响。总体而言,我们的研究结果表明,慢性运动降低了T辅助细胞和Tγδ细胞的比例,但增加了大麻素(CBR1)在T辅助细胞和自然杀伤细胞上的表达,以及白细胞介素(包括IL-1β、干扰素γ、肿瘤坏死因子α、IL-10和IL-4)的产生,表明运动赋予免疫系统更高的反应性和效率。
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引用次数: 0
Acknowledgment of Reviewers 2023. 鸣谢 2023 年审稿人。
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-01-01 Epub Date: 2023-12-21 DOI: 10.1089/jir.2023.29059.ack
{"title":"Acknowledgment of Reviewers 2023.","authors":"","doi":"10.1089/jir.2023.29059.ack","DOIUrl":"10.1089/jir.2023.29059.ack","url":null,"abstract":"","PeriodicalId":16261,"journal":{"name":"Journal of Interferon and Cytokine Research","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine Profile Response of Human Peripheral Blood Mononuclear Cells Stimulated by Bartonella bacilliformis. 杆菌状巴尔通体刺激人外周血单个核细胞的细胞因子谱反应。
IF 2.3 4区 医学 Q2 Immunology and Microbiology Pub Date : 2024-01-01 Epub Date: 2023-11-15 DOI: 10.1089/jir.2023.0107
Barbara Ymaña, Javier Enciso-Benavides, Gemma Moncunill, Maria J Pons

Carrion's disease is a neglected endemic disease found in remote Andean areas. As an overlooked disease, knowledge of innate immune responses to Bartonella bacilliformis, the etiological agent, is scarce. This study aimed to evaluate the cytokine response to B. bacilliformis using in vitro human peripheral blood mononuclear cells (PBMCs) stimulations. PBMCs from naive adults were isolated by gradient centrifugation and cocultured with heat-inactivated (HI) B. bacilliformis at different incubation times (3, 6, 12, 24, and 36 h). Cytokines, chemokines, and growth factors were determined in culture supernatants by multiplex fluorescent bead-based quantitative suspension array technology. During the first 36 h, a proinflammatory response was observed, including tumor necrosis factor-α, interleukin (IL)-1α, IL-1β, interferon-α2, and IL-6, followed by an anti-inflammatory response mainly related to IL-1RA. Moreover, high expression levels of chemokines IL-8, monocyte chemoattractant protein-1α, and macrophage inflammatory protein (MIP)-1β were detected from 3 h poststimulation and MIP-1α was detected at 24 h. Some growth factors, mainly granulocyte macrophage colony-stimulating factor and granulocyte colony-stimulating factor, and in minor concentrations vascular endothelial growth factor, epidermal growth factor, and eotaxin, were also detected. Innate response to HI B. bacilliformis stimulation consists of a rapid and strong proinflammatory response characterized by a wide range of cytokines and chemokines followed by an anti-inflammatory response and increased specific growth factors.

腐肉病是一种被忽视的地方病,常见于偏远的安第斯地区。作为一种被忽视的疾病,对病原体巴通体杆菌的先天免疫反应的了解很少。本研究旨在通过体外刺激人外周血单个核细胞(PBMCs)来评估细胞因子对芽孢杆菌的反应。通过梯度离心分离初生成人的pbmc,并在不同孵育时间(3,6,12,24和36 h)与热灭活(HI)芽孢杆菌共培养。细胞因子、趋化因子和生长因子通过基于多重荧光珠的定量悬浮阵列技术在培养上清液中进行检测。在前36小时,观察到促炎反应,包括肿瘤坏死因子-α、白细胞介素(IL)-1α、IL-1β、干扰素-α2和IL-6,随后是主要与IL- 1ra相关的抗炎反应。此外,趋化因子IL-8、单核细胞趋化蛋白-1α和巨噬细胞炎症蛋白(MIP)-1β在刺激后3小时高表达,MIP-1α在24小时高表达。部分生长因子,主要是粒细胞巨噬细胞集落刺激因子和粒细胞集落刺激因子,以及少量浓度的血管内皮生长因子、表皮生长因子和eotaxin。对HI芽孢杆菌刺激的先天反应包括快速而强烈的促炎反应,其特征是广泛的细胞因子和趋化因子,随后是抗炎反应和特异性生长因子的增加。
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引用次数: 0
期刊
Journal of Interferon and Cytokine Research
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