Hector Acosta-Rodriguez, Pratheek Bobba, Alicia Stephan, Tal Zeevi, Ajay Malhotra, Anh Tuan Tran, Simone Kaltenhauser, Laura Ment, Seyedmehdi Payabvash
Background and Purpose
Socioeconomic determinants of health impact childhood development and adult health outcomes. One key aspect is the physical environment and neighborhood where children live and grow. Emerging evidence suggests that neighborhood deprivation, often measured by the Area Deprivation Index (ADI), may influence neurodevelopment, but longitudinal and multimodal neuroimaging analyses remain limited.
Methods
We examined the association between childhood neighborhoods and brain white matter (WM) microstructural integrity using a large, demographically representative cohort from the Adolescent Brain Cognitive Development Study. We analyzed the relationship between ADI and MRI metrics of WM microstructural integrity and resting-state funtional magnetic resonance imaging (rs-fMRI) connectivity in children with data at baseline (mean age of 9.9 years) and follow-up (mean age 12.0 years), with a sample size of n = 2615.
Results
Children living in poorer neighborhoods (higher ADI) showed lower brain WM microstructural integrity at baseline and follow-up, even after adjusting for age, sex, race/ethnicity, head size, body mass index, parental education, and income levels. This reduced microstructure was seen in critical tracts, such as the superior longitudinal fasciculus, corpus callosum, and the uncinate. Additionally, baseline and follow-up rs-fMRI analysis revealed that children living in poorer neighborhoods had decreased connectivity within the retrosplenial-temporal network and between higher-order networks, such as the cingulo-opercular network.
Conclusions
These findings highlight the influence of neighborhood socioeconomic disadvantage on both WM microstructural integrity and functional brain connectivity in the preadolescent brain. Children from more deprived neighborhoods showed reduced integrity in key WM tracts and disrupted connectivity within and between higher-order networks.
{"title":"Impact of Childhood Neighborhood Deprivation on White Matter and Functional Connectivity During Adolescence","authors":"Hector Acosta-Rodriguez, Pratheek Bobba, Alicia Stephan, Tal Zeevi, Ajay Malhotra, Anh Tuan Tran, Simone Kaltenhauser, Laura Ment, Seyedmehdi Payabvash","doi":"10.1111/jon.70087","DOIUrl":"https://doi.org/10.1111/jon.70087","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Socioeconomic determinants of health impact childhood development and adult health outcomes. One key aspect is the physical environment and neighborhood where children live and grow. Emerging evidence suggests that neighborhood deprivation, often measured by the Area Deprivation Index (ADI), may influence neurodevelopment, but longitudinal and multimodal neuroimaging analyses remain limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We examined the association between childhood neighborhoods and brain white matter (WM) microstructural integrity using a large, demographically representative cohort from the Adolescent Brain Cognitive Development Study. We analyzed the relationship between ADI and MRI metrics of WM microstructural integrity and resting-state funtional magnetic resonance imaging (rs-fMRI) connectivity in children with data at baseline (mean age of 9.9 years) and follow-up (mean age 12.0 years), with a sample size of <i>n</i> = 2615.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Children living in poorer neighborhoods (higher ADI) showed lower brain WM microstructural integrity at baseline and follow-up, even after adjusting for age, sex, race/ethnicity, head size, body mass index, parental education, and income levels. This reduced microstructure was seen in critical tracts, such as the superior longitudinal fasciculus, corpus callosum, and the uncinate. Additionally, baseline and follow-up rs-fMRI analysis revealed that children living in poorer neighborhoods had decreased connectivity within the retrosplenial-temporal network and between higher-order networks, such as the cingulo-opercular network.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings highlight the influence of neighborhood socioeconomic disadvantage on both WM microstructural integrity and functional brain connectivity in the preadolescent brain. Children from more deprived neighborhoods showed reduced integrity in key WM tracts and disrupted connectivity within and between higher-order networks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enchao Qiu, Joga Chaganti, Phillip Phan, Mahdi Alizadeh, Devon Middleton, Kiran Talekar, Prabath K. Mondel, Scott H. Faro, Feroze B. Mohamed, Hsiangkuo Yuan
Background and Purpose
Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) has emerged as a promising noninvasive method for evaluating water motion that may reflect glymphatic system function. However, the reliability of DTI-ALPS measurements across different region-of-interest (ROI) selection methods remains underinvestigated. This study aimed to assess the interrater reliability among three neuroradiologists in native space and compare DTI-ALPS indices derived from ROIs placed in subjects’ native space versus standardized Montreal Neurological Institute (MNI) space.
Methods
DTI-ALPS indices from 16 healthy subjects were calculated from both left and right hemispheres using two ROI placement approaches: (1) native space ROIs manually placed by three neuroradiologists, and (2) standardized ROIs in MNI space based on the fractional anisotropy template. Interrater reliability was assessed using intraclass correlation coefficients (ICCs). The proportion of ROI overlaps among the three neuroradiologists was also evaluated. Differences between native and MNI space measurements were evaluated using related-samples Friedman's analysis with post hoc pairwise comparisons.
Results
Interrater reliability for native space ROI placement was moderate for left-sided DTI-ALPS indices (ICC = 0.599) and good for right-sided DTI-ALPS indices (ICC = 0.807). Spatial overlap analysis revealed poor Dice similarity coefficients across all ROI types (range: 0.047–0.312), with right association ROIs showing higher spatial consistency. Significant differences were found between native and MNI space measurements for left-sided DTI-ALPS indices (p = 0.002) but not for right-sided DTI-ALPS indices (p = 0.913).
Conclusion
These findings highlight the importance of standardized ROI selection approaches for clinical applications of DTI-ALPS.
{"title":"Reliability and Spatial Consistency of MR Diffusion Tensor Imaging Measures Along the Cerebral Perivascular Space","authors":"Enchao Qiu, Joga Chaganti, Phillip Phan, Mahdi Alizadeh, Devon Middleton, Kiran Talekar, Prabath K. Mondel, Scott H. Faro, Feroze B. Mohamed, Hsiangkuo Yuan","doi":"10.1111/jon.70086","DOIUrl":"https://doi.org/10.1111/jon.70086","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) has emerged as a promising noninvasive method for evaluating water motion that may reflect glymphatic system function. However, the reliability of DTI-ALPS measurements across different region-of-interest (ROI) selection methods remains underinvestigated. This study aimed to assess the interrater reliability among three neuroradiologists in native space and compare DTI-ALPS indices derived from ROIs placed in subjects’ native space versus standardized Montreal Neurological Institute (MNI) space.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>DTI-ALPS indices from 16 healthy subjects were calculated from both left and right hemispheres using two ROI placement approaches: (1) native space ROIs manually placed by three neuroradiologists, and (2) standardized ROIs in MNI space based on the fractional anisotropy template. Interrater reliability was assessed using intraclass correlation coefficients (ICCs). The proportion of ROI overlaps among the three neuroradiologists was also evaluated. Differences between native and MNI space measurements were evaluated using related-samples Friedman's analysis with post hoc pairwise comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Interrater reliability for native space ROI placement was moderate for left-sided DTI-ALPS indices (ICC = 0.599) and good for right-sided DTI-ALPS indices (ICC = 0.807). Spatial overlap analysis revealed poor Dice similarity coefficients across all ROI types (range: 0.047–0.312), with right association ROIs showing higher spatial consistency. Significant differences were found between native and MNI space measurements for left-sided DTI-ALPS indices (<i>p</i> = 0.002) but not for right-sided DTI-ALPS indices (<i>p</i> = 0.913).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings highlight the importance of standardized ROI selection approaches for clinical applications of DTI-ALPS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonadab dos Santos Silva, Claudia C. F. Vasconcelos, Carina T. Spedo, Carolina Alvarez Azevedo, Larissa C. S. Lopes, Francesco La Rosa, Carolina B. Moura, Osvaldo Nascimento, Fernanda Cristina Rueda Lopes
Background and Purpose
Cognitive impairment is common and disabling in multiple sclerosis (MS), yet poorly explained by lesion burden. This study aimed to determine whether the indirect impact of lesions, quantified through disconnectomes, explains multidomain cognitive deficits more effectively than lesion load, and to identify specific white matter tracts underlying these deficits.
Methods
Thirty adults with MS completed the Brief International Cognitive Assessment for MS, covering processing speed (Symbol Digit Modalities Test; SDMT), verbal memory (California Verbal Learning Test-II; CVLT-II), and visuospatial memory (Brief Visuospatial Memory Test–Revised; BVMT-R). Lesions were segmented using 3 Tesla fluid-attenuated inversion recovery images and used to estimate tract-specific disconnections and generate voxel-wise disconnectome maps. Tract-specific and voxel-wise analyses were used to identify disconnection patterns associated with cognitive performance.
Results
Cognition was impaired across all domains (all p < 0.001). Disconnectome volume was a significant independent determinant of cognitive performance (β = –0.41, p = 0.004), whereas lesion volume was not. Tract-specific analyses revealed distinct disconnection patterns: slower SDMT was associated with left cingulum posterior (β = −0.310, 95% confidence interval [CI] [−0.599, −0.021]); poorer CVLT-II with left arcuate fasciculus (β = −0.232, 95% CI [−0.435, −0.030]); and lower BVMT-R with right cingulum posterior (β = −0.218, 95% CI [−0.383, −0.054]). Voxel-wise analyses identified where the strongest associations between disconnectomes and cognitive performance were located.
Conclusion
Lesion-driven disconnection is a more robust determinant of cognitive impairment in MS than lesion burden alone, and disconnectome mapping may help understand the indirect network-level mechanisms underlying cognitive deficits in MS.
{"title":"Lesion-Based Disconnectome Explains Cognitive Outcomes in Multiple Sclerosis","authors":"Jonadab dos Santos Silva, Claudia C. F. Vasconcelos, Carina T. Spedo, Carolina Alvarez Azevedo, Larissa C. S. Lopes, Francesco La Rosa, Carolina B. Moura, Osvaldo Nascimento, Fernanda Cristina Rueda Lopes","doi":"10.1111/jon.70081","DOIUrl":"https://doi.org/10.1111/jon.70081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Cognitive impairment is common and disabling in multiple sclerosis (MS), yet poorly explained by lesion burden. This study aimed to determine whether the indirect impact of lesions, quantified through disconnectomes, explains multidomain cognitive deficits more effectively than lesion load, and to identify specific white matter tracts underlying these deficits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty adults with MS completed the Brief International Cognitive Assessment for MS, covering processing speed (Symbol Digit Modalities Test; SDMT), verbal memory (California Verbal Learning Test-II; CVLT-II), and visuospatial memory (Brief Visuospatial Memory Test–Revised; BVMT-R). Lesions were segmented using 3 Tesla fluid-attenuated inversion recovery images and used to estimate tract-specific disconnections and generate voxel-wise disconnectome maps. Tract-specific and voxel-wise analyses were used to identify disconnection patterns associated with cognitive performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Cognition was impaired across all domains (all <i>p</i> < 0.001). Disconnectome volume was a significant independent determinant of cognitive performance (β = –0.41, <i>p</i> = 0.004), whereas lesion volume was not. Tract-specific analyses revealed distinct disconnection patterns: slower SDMT was associated with left cingulum posterior (β = −0.310, 95% confidence interval [CI] [−0.599, −0.021]); poorer CVLT-II with left arcuate fasciculus (β = −0.232, 95% CI [−0.435, −0.030]); and lower BVMT-R with right cingulum posterior (β = −0.218, 95% CI [−0.383, −0.054]). Voxel-wise analyses identified where the strongest associations between disconnectomes and cognitive performance were located.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Lesion-driven disconnection is a more robust determinant of cognitive impairment in MS than lesion burden alone, and disconnectome mapping may help understand the indirect network-level mechanisms underlying cognitive deficits in MS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahla Radmard, Mona Gad, Ali Sheikhy, Richard Dagher, Vivek Yedavalli, Licia P. Luna
Background
Alzheimer's disease (AD) and mild cognitive impairment (MCI) are two common conditions associated with cognitive decline. With global dementia cases rising, identifying the most accurate imaging method for diagnosis is essential.
Methods
Following Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, we systematically reviewed studies utilizing arterial spin labeling magnetic resonance imaging (ASL-MRI) and [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for neurodegenerative disorders. Searches in PubMed/MEDLINE, Scopus, and Embase led to 17 studies directly comparing these modalities for MCI/AD diagnosis. Seven studies met criteria for meta-analysis based on interreader agreement and area under the curve (AUC) data. Meta-analysis was performed using the R “Mada” package, with study heterogeneity assessed via the Zhou and Dendukuri approach.
Results
Meta-analysis of seven studies showed FDG-PET had a slightly higher AUC (0.864, sensitivity 0.81, specificity 0.80) compared to ASL-MRI (AUC 0.836, sensitivity 0.73, specificity 0.80), but no statistically significant difference. Low heterogeneity was observed (I2: 9.4% for FDG-PET, 6.5% for ASL-MRI). In MCI subgroup analysis, FDG-PET outperformed ASL-MRI with significantly higher sensitivity (0.90 vs. 0.75), specificity (0.91 vs. 0.73), and AUC (0.92 vs. 0.80, p < 0.001).
Conclusion
FDG-PET and ASL-MRI demonstrate comparable diagnostic accuracy for AD and MCI. Selection between modalities may depend on availability, cost, and safety considerations.
Clinical Relevance/Application
Both FDG-PET and MRI-ASL are effective at identifying MCI and AD, enabling accurate diagnosis. The choice of which modality to use may be addressed by cost, availability, and consideration of other potential diagnoses.
阿尔茨海默病（AD）和轻度认知障碍（MCI）是两种与认知能力下降相关的常见疾病。随着全球痴呆症病例的增加，确定最准确的诊断成像方法至关重要。方法根据系统评价和荟萃分析方案的首选报告项目，我们系统地回顾了利用动脉自旋标记磁共振成像（ASL-MRI）和[18F]-2-氟-2-脱氧-d -葡萄糖正电子发射断层扫描（FDG-PET）治疗神经退行性疾病的研究。在PubMed/MEDLINE、Scopus和Embase中搜索，有17项研究直接比较了这些模式对MCI/AD的诊断。7项研究符合基于解读者一致性和曲线下面积（AUC）数据的meta分析标准。采用R“Mada”软件包进行meta分析，通过Zhou和Dendukuri方法评估研究异质性。结果7项研究荟萃分析显示，FDG-PET的AUC（0.864，敏感性0.81，特异性0.80）略高于ASL-MRI (AUC 0.836，敏感性0.73，特异性0.80)，但差异无统计学意义。观察到低异质性（I2: FDG-PET为9.4%，ASL-MRI为6.5%）。在MCI亚组分析中，FDG-PET的灵敏度（0.90 vs. 0.75）、特异性（0.91 vs. 0.73）和AUC （0.92 vs. 0.80, p < 0.001）明显优于ASL-MRI。结论FDG-PET和ASL-MRI对AD和MCI的诊断准确性相当。模式之间的选择可能取决于可用性、成本和安全性考虑。FDG-PET和MRI-ASL均能有效识别MCI和AD，实现准确诊断。使用哪种方式的选择可以根据成本、可获得性和其他潜在诊断的考虑来解决。
{"title":"Functional Imaging in Alzheimer's Disease: A Systematic Review and Meta-Analysis of ASL-MRI and FDG-PET","authors":"Mahla Radmard, Mona Gad, Ali Sheikhy, Richard Dagher, Vivek Yedavalli, Licia P. Luna","doi":"10.1111/jon.70080","DOIUrl":"https://doi.org/10.1111/jon.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Alzheimer's disease (AD) and mild cognitive impairment (MCI) are two common conditions associated with cognitive decline. With global dementia cases rising, identifying the most accurate imaging method for diagnosis is essential.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, we systematically reviewed studies utilizing arterial spin labeling magnetic resonance imaging (ASL-MRI) and [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) for neurodegenerative disorders. Searches in PubMed/MEDLINE, Scopus, and Embase led to 17 studies directly comparing these modalities for MCI/AD diagnosis. Seven studies met criteria for meta-analysis based on interreader agreement and area under the curve (AUC) data. Meta-analysis was performed using the R “Mada” package, with study heterogeneity assessed via the Zhou and Dendukuri approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Meta-analysis of seven studies showed FDG-PET had a slightly higher AUC (0.864, sensitivity 0.81, specificity 0.80) compared to ASL-MRI (AUC 0.836, sensitivity 0.73, specificity 0.80), but no statistically significant difference. Low heterogeneity was observed (<i>I</i><sup>2</sup>: 9.4% for FDG-PET, 6.5% for ASL-MRI). In MCI subgroup analysis, FDG-PET outperformed ASL-MRI with significantly higher sensitivity (0.90 vs. 0.75), specificity (0.91 vs. 0.73), and AUC (0.92 vs. 0.80, <i>p</i> < 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>FDG-PET and ASL-MRI demonstrate comparable diagnostic accuracy for AD and MCI. Selection between modalities may depend on availability, cost, and safety considerations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Relevance/Application</h3>\u0000 \u0000 <p>Both FDG-PET and MRI-ASL are effective at identifying MCI and AD, enabling accurate diagnosis. The choice of which modality to use may be addressed by cost, availability, and consideration of other potential diagnoses.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Kanzawa, Shiori Amemiya, Hidemasa Takao, Osamu Abe
Background and Purpose
This study aims to characterize hemodynamic alterations in gliomas by analyzing global signal metrics and amplitude of low-frequency fluctuations (ALFF).
Methods
We analyzed resting-state functional MRI data from an open dataset. A total of 29 glioma patients (17 men; mean age: 44.2 ± 13.9 years; 16 high-grade) were included. Global signal cross-correlation (GSXC), representing the maximum cross-correlation value between each voxel's time series and the average gray matter signal of the contralateral hemisphere, and ALFF were calculated. Regions of interest for tumor were defined and mirrored to the contralateral side for comparison. Linear mixed-effects models were used to examine effects of tumor grade and measurement side on GSXC and ALFF. Post hoc analyses compared tumor versus contralateral regions.
Results
GSXC was significantly reduced in tumor regions compared to the contralateral hemisphere, regardless of tumor grade (low-grade: 0.31 ± 0.21 vs. 0.45 ± 0.16, p = 0.005; high-grade: 0.39 ± 0.17 vs. 0.55 ± 0.13, p < 0.001). ALFF was significantly lower in low-grade tumors compared to the contralateral side (0.65 ± 0.15 vs. 0.77 ± 0.14, p = 0.005), while no significant difference was found in high-grade tumors (0.80 ± 0.18 vs. 0.77 ± 0.10, p = 0.46).
Conclusions
Our findings suggest that GSXC and ALFF provide complementary pathological information on glioma. GSXC indicates impaired cerebrovascular reactivity due to gliovascular uncoupling, whereas ALFF shows an increase in high-grade gliomas likely reflecting greater total vascularity.
背景与目的本研究旨在通过分析神经胶质瘤的整体信号指标和低频波动（ALFF）的幅度来表征血液动力学的改变。方法对开放数据集的静息状态功能MRI数据进行分析。共纳入29例胶质瘤患者（男性17例，平均年龄44.2±13.9岁，高级别16例）。计算各体素时间序列与对侧半球平均灰质信号的最大互相关值Global signal cross-correlation （GSXC）和ALFF。确定肿瘤感兴趣的区域，并镜像到对侧进行比较。采用线性混合效应模型检验肿瘤分级和测量侧对GSXC和ALFF的影响。事后分析比较肿瘤和对侧区域。结果与对侧半球相比，GSXC在肿瘤区域显著减少，与肿瘤分级无关（低分级：0.31±0.21 vs 0.45±0.16,p = 0.005；高分级：0.39±0.17 vs 0.55±0.13,p < 0.001）。低级别肿瘤的ALFF明显低于对侧（0.65±0.15比0.77±0.14,p = 0.005），而高级别肿瘤的ALFF差异无统计学意义（0.80±0.18比0.77±0.10,p = 0.46）。结论GSXC和ALFF为胶质瘤提供了互补的病理信息。GSXC表明由于胶质血管解偶联导致脑血管反应性受损，而ALFF显示高级别胶质瘤的增加可能反映了更大的总血管。
{"title":"Characterizing Hemodynamic Alterations in Glioma: Insights From Resting-State Functional MRI","authors":"Jun Kanzawa, Shiori Amemiya, Hidemasa Takao, Osamu Abe","doi":"10.1111/jon.70082","DOIUrl":"https://doi.org/10.1111/jon.70082","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>This study aims to characterize hemodynamic alterations in gliomas by analyzing global signal metrics and amplitude of low-frequency fluctuations (ALFF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed resting-state functional MRI data from an open dataset. A total of 29 glioma patients (17 men; mean age: 44.2 ± 13.9 years; 16 high-grade) were included. Global signal cross-correlation (GSXC), representing the maximum cross-correlation value between each voxel's time series and the average gray matter signal of the contralateral hemisphere, and ALFF were calculated. Regions of interest for tumor were defined and mirrored to the contralateral side for comparison. Linear mixed-effects models were used to examine effects of tumor grade and measurement side on GSXC and ALFF. Post hoc analyses compared tumor versus contralateral regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>GSXC was significantly reduced in tumor regions compared to the contralateral hemisphere, regardless of tumor grade (low-grade: 0.31 ± 0.21 vs. 0.45 ± 0.16, <i>p</i> = 0.005; high-grade: 0.39 ± 0.17 vs. 0.55 ± 0.13, <i>p</i> < 0.001). ALFF was significantly lower in low-grade tumors compared to the contralateral side (0.65 ± 0.15 vs. 0.77 ± 0.14, <i>p</i> = 0.005), while no significant difference was found in high-grade tumors (0.80 ± 0.18 vs. 0.77 ± 0.10, <i>p</i> = 0.46).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that GSXC and ALFF provide complementary pathological information on glioma. GSXC indicates impaired cerebrovascular reactivity due to gliovascular uncoupling, whereas ALFF shows an increase in high-grade gliomas likely reflecting greater total vascularity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 5","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masoud Hassanzadeh, Alyssa Ailion, Simon K. Warfield, Taha Gholipour, Shan Siddiqi, Steven M. Stufflebeam, Elmira Hassanzadeh
Background and Purpose
Resting-state fMRI (rs-fMRI) is increasingly used to map brain networks in patients under anesthesia, but technical factors can affect its utility. We evaluated the effects of sevoflurane, multiband acceleration, and scan duration on rs-fMRI signal quality and within-subject reliability under anesthesia.
Methods
We retrospectively analyzed 64 clinical rs-fMRI scans acquired under anesthesia, with or without sevoflurane and multiband factor 5 acceleration. Temporal signal-to-noise ratio (tSNR) was used as a measure of signal quality. For each patient, the scan was split in half, and seed-based connectivity maps were generated for the primary motor cortex (M1), posterior cingulate cortex (PCC), and subgenual anterior cingulate cortex (sgACC). Split-half spatial correlations were used to assess within-subject reliability. Group comparisons examined differences in tSNR and reliability across conditions, and correlations with scan duration were tested.
Results
Multiband acceleration was associated with significantly lower tSNR (U = 652.0, p = 8.9 × 10─6) and reduced split-half reliability for M1 (p = 0.019), PCC (p = 0.010), and sgACC (p = 0.0064). Sevoflurane showed no significant effect on tSNR or reliability. Longer scan duration correlated with improved reliability for M1 (r = 0.38, p = 0.003) but not for PCC or sgACC. No correlation was found between tSNR and reliability.
Conclusion
Hight multiband acceleration reduces both signal quality and reliability of rs-fMRI under anesthesia. Sevoflurane had no measurable effect. The lack of correlation between tSNR and reliability underscores the need for more robust metrics when evaluating scan quality.
{"title":"High Multiband Acceleration Degrades Resting-State Functional MRI Reliability and Signal Quality Under Anesthesia","authors":"Masoud Hassanzadeh, Alyssa Ailion, Simon K. Warfield, Taha Gholipour, Shan Siddiqi, Steven M. Stufflebeam, Elmira Hassanzadeh","doi":"10.1111/jon.70075","DOIUrl":"https://doi.org/10.1111/jon.70075","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Resting-state fMRI (rs-fMRI) is increasingly used to map brain networks in patients under anesthesia, but technical factors can affect its utility. We evaluated the effects of sevoflurane, multiband acceleration, and scan duration on rs-fMRI signal quality and within-subject reliability under anesthesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 64 clinical rs-fMRI scans acquired under anesthesia, with or without sevoflurane and multiband factor 5 acceleration. Temporal signal-to-noise ratio (tSNR) was used as a measure of signal quality. For each patient, the scan was split in half, and seed-based connectivity maps were generated for the primary motor cortex (M1), posterior cingulate cortex (PCC), and subgenual anterior cingulate cortex (sgACC). Split-half spatial correlations were used to assess within-subject reliability. Group comparisons examined differences in tSNR and reliability across conditions, and correlations with scan duration were tested.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Multiband acceleration was associated with significantly lower tSNR (<i>U</i> = 652.0, <i>p</i> = 8.9 × 10─<sup>6</sup>) and reduced split-half reliability for M1 (<i>p</i> = 0.019), PCC (<i>p</i> = 0.010), and sgACC (<i>p</i> = 0.0064). Sevoflurane showed no significant effect on tSNR or reliability. Longer scan duration correlated with improved reliability for M1 (<i>r</i> = 0.38, <i>p</i> = 0.003) but not for PCC or sgACC. No correlation was found between tSNR and reliability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hight multiband acceleration reduces both signal quality and reliability of rs-fMRI under anesthesia. Sevoflurane had no measurable effect. The lack of correlation between tSNR and reliability underscores the need for more robust metrics when evaluating scan quality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144891680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew C. McClelland, Colin A. Ellis, Emory Kuo, Kenny Q. Ye, Ramani Balu, Suyash Mohan
Background and Purpose
Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state with characteristic imaging findings. While classic PRES typically involves parieto-occipital edema, atypical cases present with variable involvement of deep gray nuclei, brainstem, cerebellum, and corpus callosum, which may complicate diagnosis. This study aims to characterize the neuroimaging features of “atypical” PRES in a large cohort and evaluate relationships with clinical variables and outcomes.
Methods
We retrospectively analyzed neuroimaging data from patients diagnosed with PRES, identifying cases with atypical edema patterns. Relationships between MRI findings, clinical variables, and outcomes were assessed with univariable and multivariable regression analyses.
Results
A total of 184 PRES cases were analyzed. 71.7% had “atypical” imaging findings. Atypical edema was associated with older age (odds ratio [OR] 2.96 ≥52 years, p = 0.002) and negatively associated with pregnancy (OR 0.20, p<0.001). These associations were seen in a subset of atypical locations, particularly those supplied by the posterior circulation. Additionally, certain atypical edema patterns were correlated with prolonged hospital stays and reduced clinical reversibility, suggesting a potential impact on patient outcomes.
Conclusion
In this large series of PRES cases, atypical imaging findings were common. Atypical edema, including a posterior circulation pattern, was seen more commonly in older patients, less commonly in pregnancy, and may represent a more severe form of this syndrome with worse outcomes. Recognizing these atypical imaging patterns is crucial for timely intervention and improved patient outcomes.
背景与目的后路可逆性脑病综合征（PRES）是一种具有特征性影像学表现的神经毒性状态。典型的PRES通常包括顶枕水肿，非典型病例表现为不同程度的深灰色核、脑干、小脑和胼胝体受累，这可能使诊断复杂化。本研究旨在在一个大队列中描述“非典型”PRES的神经影像学特征，并评估其与临床变量和结果的关系。方法回顾性分析PRES患者的神经影像学资料，确定非典型水肿的病例。通过单变量和多变量回归分析评估MRI表现、临床变量和结果之间的关系。结果共分析了184例PRES病例。71.7%有“非典型”影像学表现。非典型水肿与年龄较大相关（比值比[OR] 2.96≥52岁，p = 0.002），与妊娠负相关（比值比[OR] 0.20, p = 0.001）。这些关联见于非典型部位的一个子集，特别是由后循环供应的部位。此外，某些非典型水肿模式与住院时间延长和临床可逆性降低相关，表明对患者预后有潜在影响。结论在这一系列的PRES病例中，不典型的影像学表现是常见的。非典型水肿，包括后循环模式，在老年患者中更常见，在妊娠患者中较少见，并且可能代表该综合征的更严重形式，预后更差。认识到这些非典型影像模式对于及时干预和改善患者预后至关重要。
{"title":"Atypical Edema in Posterior Reversible Encephalopathy Syndrome: Clinical Associations and Outcome","authors":"Andrew C. McClelland, Colin A. Ellis, Emory Kuo, Kenny Q. Ye, Ramani Balu, Suyash Mohan","doi":"10.1111/jon.70078","DOIUrl":"https://doi.org/10.1111/jon.70078","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state with characteristic imaging findings. While classic PRES typically involves parieto-occipital edema, atypical cases present with variable involvement of deep gray nuclei, brainstem, cerebellum, and corpus callosum, which may complicate diagnosis. This study aims to characterize the neuroimaging features of “atypical” PRES in a large cohort and evaluate relationships with clinical variables and outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed neuroimaging data from patients diagnosed with PRES, identifying cases with atypical edema patterns. Relationships between MRI findings, clinical variables, and outcomes were assessed with univariable and multivariable regression analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 184 PRES cases were analyzed. 71.7% had “atypical” imaging findings. Atypical edema was associated with older age (odds ratio [OR] 2.96 ≥52 years, <i>p</i> = 0.002) and negatively associated with pregnancy (OR 0.20, <i>p</i><0.001). These associations were seen in a subset of atypical locations, particularly those supplied by the posterior circulation. Additionally, certain atypical edema patterns were correlated with prolonged hospital stays and reduced clinical reversibility, suggesting a potential impact on patient outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this large series of PRES cases, atypical imaging findings were common. Atypical edema, including a posterior circulation pattern, was seen more commonly in older patients, less commonly in pregnancy, and may represent a more severe form of this syndrome with worse outcomes. Recognizing these atypical imaging patterns is crucial for timely intervention and improved patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cerebral collateral circulation is a critical determinant of infarct evolution, therapeutic response, and clinical outcomes in patients with acute ischemic stroke. While the concept of “time is brain” has traditionally guided reperfusion therapy, recent evidence—particularly from trials like DAWN and DEFUSE 3—suggests that collateral status more accurately determines the rate of infarct progression and the extent of salvageable tissue. This comprehensive review synthesizes advances in neuroimaging modalities for evaluating cerebral collaterals, emphasizing their role in refining stroke diagnosis, guiding patient selection, and informing personalized treatment strategies. Structural approaches such as multiphase and dynamic CT angiography, alongside perfusion-based parameters (e.g., cerebral blood volume, hypoperfusion intensity ratio, and Tmax delay maps), are examined. Cortical venous outflow, assessed via the cortical vein opacification score, emerges as an independent predictor of outcome, complementing arterial grading. Susceptibility-weighted imaging, arterial spin labeling, and metabolic and molecular techniques (e.g., PET imaging of inflammation and vascular remodeling) offer functional insights beyond traditional angiography. Biomarkers such as matrix metalloproteinase-9, integrin αvβ3, and translocator protein–targeted PET ligands are discussed in relation to collateral vessel dynamics. Finally, we explore the integration of genetically informed brain atlases, spatial transcriptomics, and imaging–genomic platforms for high-resolution collateral phenotyping. Although promising, these modalities face challenges related to heterogeneity, limited validation, and the lack of standardization. A biologically informed, multimodal, and automated imaging paradigm may herald a new era of precision stroke medicine.
{"title":"Advances in Collateral Neuroimaging for Acute Ischemic Stroke: Redefining Time and Tissue Windows in the Reperfusion Era","authors":"Ritwick Mondal, Shramana Deb, Nirmalya Ray, Ananya Sengupta, Vramanti Sarkar, Subhadeep Banerjee, Avik Mukherjee, Jayanta Roy, Julián Benito-León","doi":"10.1111/jon.70079","DOIUrl":"https://doi.org/10.1111/jon.70079","url":null,"abstract":"<p>Cerebral collateral circulation is a critical determinant of infarct evolution, therapeutic response, and clinical outcomes in patients with acute ischemic stroke. While the concept of “time is brain” has traditionally guided reperfusion therapy, recent evidence—particularly from trials like DAWN and DEFUSE 3—suggests that collateral status more accurately determines the rate of infarct progression and the extent of salvageable tissue. This comprehensive review synthesizes advances in neuroimaging modalities for evaluating cerebral collaterals, emphasizing their role in refining stroke diagnosis, guiding patient selection, and informing personalized treatment strategies. Structural approaches such as multiphase and dynamic CT angiography, alongside perfusion-based parameters (e.g., cerebral blood volume, hypoperfusion intensity ratio, and Tmax delay maps), are examined. Cortical venous outflow, assessed via the cortical vein opacification score, emerges as an independent predictor of outcome, complementing arterial grading. Susceptibility-weighted imaging, arterial spin labeling, and metabolic and molecular techniques (e.g., PET imaging of inflammation and vascular remodeling) offer functional insights beyond traditional angiography. Biomarkers such as matrix metalloproteinase-9, integrin αvβ3, and translocator protein–targeted PET ligands are discussed in relation to collateral vessel dynamics. Finally, we explore the integration of genetically informed brain atlases, spatial transcriptomics, and imaging–genomic platforms for high-resolution collateral phenotyping. Although promising, these modalities face challenges related to heterogeneity, limited validation, and the lack of standardization. A biologically informed, multimodal, and automated imaging paradigm may herald a new era of precision stroke medicine.</p>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jakob Pansell, Tina Thomsson, Emelie Eng, Andreas Wallin, Mohammad Hirzallah
Background and purpose
Optic nerve sheath diameter (ONSD) measured by point-of-care ultrasound (POCUS) is a commonly used non-invasive estimate of intracranial pressure (ICP). However, methodological variations limit standardization of this promising technique. Different imaging axes are identified as one such source of ONSD POCUS methodological variation. This study aimed to evaluate the agreement and diagnostic accuracy for elevated ICP between transverse and sagittal ONSD measurements.
Methods
We conducted a post-hoc analysis of 213 intensive care patients from three prior studies. ONSD was measured in both transverse and sagittal planes, externally (ONSDext) and internally (ONSDint) of the dura mater. Agreement was assessed using Lin's concordance correlation coefficient (CCC). Diagnostic accuracy for detecting ICP ≥20 mmHg was evaluated using area under the receiver operator characteristics curve (AUROC) analyses in a subset of 139 patients.
Results
Sagittal ONSD was significantly larger than transverse ONSD (median difference 0.2 mm, p<0.001). Agreement between transverse and sagittal ONSD was poor (CCC: 0.65 and 0.70 for right and left side ONSDext, and 0.43 and 0.51 for right and left side ONSDint). No significant differences in AUROC were found between transverse, sagittal, or averaged measurements.
Conclusions
Transverse and sagittal ONSD measurements are not interchangeable due to significant differences and poor agreement. Diagnostic accuracy was similar across methods. These findings support continued use of transverse measurement as the standard approach for ONSD POCUS in clinical practice.
背景与目的视神经鞘直径（ONSD）是一种常用的无创颅内压（ICP）测量方法。然而，方法上的差异限制了这项有前途的技术的标准化。不同的成像轴被认为是ONSD POCUS方法差异的一个来源。本研究旨在评估横向和矢状面ONSD测量之间ICP升高的一致性和诊断准确性。方法：我们对之前三项研究中的213例重症监护患者进行了事后分析。在横切面和矢状面，硬脑膜外部（ONSDext）和内部（ONSDint）测量ONSD。采用Lin’s一致性相关系数（CCC）评价一致性。对139例患者进行受试者操作特征曲线下面积（AUROC）分析，评估检测ICP≥20 mmHg的诊断准确性。结果矢状面ONSD明显大于横面ONSD（中位数差0.2 mm, p<0.001）。横向和矢状面ONSD的一致性较差（左右两侧ONSDext的CCC分别为0.65和0.70，左右两侧ONSDint的CCC分别为0.43和0.51）。横切面、矢状面或平均测量的AUROC无显著差异。结论横切面和矢状面ONSD测量结果差异显著且一致性差，不能互换。不同方法的诊断准确性相似。这些发现支持在临床实践中继续使用横向测量作为ONSD POCUS的标准方法。
{"title":"Optic Nerve Sheath Diameter: Which Axis Should Be Measured?","authors":"Jakob Pansell, Tina Thomsson, Emelie Eng, Andreas Wallin, Mohammad Hirzallah","doi":"10.1111/jon.70076","DOIUrl":"https://doi.org/10.1111/jon.70076","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and purpose</h3>\u0000 \u0000 <p>Optic nerve sheath diameter (ONSD) measured by point-of-care ultrasound (POCUS) is a commonly used non-invasive estimate of intracranial pressure (ICP). However, methodological variations limit standardization of this promising technique. Different imaging axes are identified as one such source of ONSD POCUS methodological variation. This study aimed to evaluate the agreement and diagnostic accuracy for elevated ICP between transverse and sagittal ONSD measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a post-hoc analysis of 213 intensive care patients from three prior studies. ONSD was measured in both transverse and sagittal planes, externally (ONSDext) and internally (ONSDint) of the dura mater. Agreement was assessed using Lin's concordance correlation coefficient (CCC). Diagnostic accuracy for detecting ICP ≥20 mmHg was evaluated using area under the receiver operator characteristics curve (AUROC) analyses in a subset of 139 patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sagittal ONSD was significantly larger than transverse ONSD (median difference 0.2 mm, p<0.001). Agreement between transverse and sagittal ONSD was poor (CCC: 0.65 and 0.70 for right and left side ONSDext, and 0.43 and 0.51 for right and left side ONSDint). No significant differences in AUROC were found between transverse, sagittal, or averaged measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Transverse and sagittal ONSD measurements are not interchangeable due to significant differences and poor agreement. Diagnostic accuracy was similar across methods. These findings support continued use of transverse measurement as the standard approach for ONSD POCUS in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Byungseok Kim, Ik-Dong Yoo, Hyeonseok S. Jeong, Yong-An Chung, In-Uk Song
Background and Purpose
Isolated cervical dystonia is characterized by sustained or intermittent neck movements caused by involuntary muscle contractions, resulting in abnormal movements or postures of cervical areas. We measured altered regional cerebral blood flow (rCBF) in patients with idiopathic cervical dystonia compared to healthy controls and explored the correlation between dystonia severity and rCBF patterns.
Methods
A total of 38 patients with isolated cervical dystonia and 29 healthy controls were recruited. All subjects underwent Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and Tc-99m HMPAO SPECT; TWSTRS was used to assess the severity of dystonia. rCBF was compared between groups using voxel-wise statistical analyses. Associations between rCBF in significant clusters and TWSTRS scores were examined using linear regression.
Results
Compared with controls, patients with cervical dystonia exhibited reduced rCBF in brain regions implicated in sensory processing, motor control, and higher cognitive functions, including the left middle temporal gyrus, right postcentral gyrus, right lingual gyrus, left precuneus, right temporal pole, right middle cingulate gyrus, and right anterior cingulate gyrus. Although reduced rCBF was observed in seven regions, only the right temporal pole showed a significant correlation with TWSTRS motor scores. Reduced rCBF in the right temporal pole negatively correlated with higher TWSTRS scores in dystonia patients.
Conclusion
The negative correlation between reduced rCBF in the right temporal pole and increased TWSTRS scores highlights a potential association between altered cerebral perfusion and dystonic symptom severity. Understanding these alterations could offer insights into the neurobiological basis of cervical dystonia, aiding targeted therapeutic interventions.
{"title":"SPECT Cerebral Perfusion Patterns in Isolated Cervical Dystonia","authors":"Byungseok Kim, Ik-Dong Yoo, Hyeonseok S. Jeong, Yong-An Chung, In-Uk Song","doi":"10.1111/jon.70073","DOIUrl":"https://doi.org/10.1111/jon.70073","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Isolated cervical dystonia is characterized by sustained or intermittent neck movements caused by involuntary muscle contractions, resulting in abnormal movements or postures of cervical areas. We measured altered regional cerebral blood flow (rCBF) in patients with idiopathic cervical dystonia compared to healthy controls and explored the correlation between dystonia severity and rCBF patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 38 patients with isolated cervical dystonia and 29 healthy controls were recruited. All subjects underwent Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and Tc-99m HMPAO SPECT; TWSTRS was used to assess the severity of dystonia. rCBF was compared between groups using voxel-wise statistical analyses. Associations between rCBF in significant clusters and TWSTRS scores were examined using linear regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with controls, patients with cervical dystonia exhibited reduced rCBF in brain regions implicated in sensory processing, motor control, and higher cognitive functions, including the left middle temporal gyrus, right postcentral gyrus, right lingual gyrus, left precuneus, right temporal pole, right middle cingulate gyrus, and right anterior cingulate gyrus. Although reduced rCBF was observed in seven regions, only the right temporal pole showed a significant correlation with TWSTRS motor scores. Reduced rCBF in the right temporal pole negatively correlated with higher TWSTRS scores in dystonia patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The negative correlation between reduced rCBF in the right temporal pole and increased TWSTRS scores highlights a potential association between altered cerebral perfusion and dystonic symptom severity. Understanding these alterations could offer insights into the neurobiological basis of cervical dystonia, aiding targeted therapeutic interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"35 4","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.70073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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