Journal of Neuroimaging最新文献_第5页

Lower admission stroke severity is associated with good collateral status in distal medium vessel occlusion stroke 在远端中血管闭塞性卒中中，较低的入院卒中严重程度与良好的侧支状态相关。

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-05-26 DOI: 10.1111/jon.13208

Janet Mei, Hamza A. Salim, Dhairya A. Lakhani, Aneri Balar, Basel Musmar, Nimer Adeeb, Meisam Hoseinyazdi, Licia Luna, Francis Deng, Nathan Z. Hyson, Adam A. Dmytriw, Adrien Guenego, Tobias D. Faizy, Jeremy J. Heit, Gregory W. Albers, Victor C. Urrutia, Raf Llinas, Elisabeth B. Marsh, Argye E. Hillis, Kambiz Nael, Vivek S. Yedavalli

Background and Purpose

Distal medium vessel occlusions (DMVOs) are a significant contributor to acute ischemic stroke (AIS), with collateral status (CS) playing a pivotal role in modulating ischemic damage progression. We aimed to explore baseline characteristics associated with CS in AIS-DMVO.

Methods

This retrospective analysis of a prospectively collected database enrolled 130 AIS-DMVO patients from two comprehensive stroke centers. Baseline characteristics, including patient demographics, admission National Institutes of Health Stroke Scale (NIHSS) score, admission Los Angeles Motor Scale (LAMS) score, and co-morbidities, including hypertension, hyperlipidemia, diabetes, coronary artery disease, atrial fibrillation, and history of transient ischemic attack or stroke, were collected. The analysis was dichotomized to good CS, reflected by hypoperfusion index ratio (HIR) <.3, versus poor CS, reflected by HIR ≥.3.

Results

Good CS was observed in 34% of the patients. As to the occluded location, 43.8% occurred in proximal M2, 16.9% in mid M2, 35.4% in more distal middle cerebral artery, and 3.8% in distal anterior cerebral artery. In multivariate logistic analysis, a lower NIHSS score and a lower LAMS score were both independently associated with a good CS (odds ratio [OR]: 0.88, 95% confidence interval [CI]: 0.82-0.95, p < .001 and OR: 0.77, 95% CI: 0.62-0.96, p = .018, respectively). Patients with poor CS were more likely to manifest as moderate to severe stroke (29.1% vs. 4.5%, p < .001), while patients with good CS had a significantly higher chance of having a minor stroke clinically (40.9% vs. 12.8%, p < .001).

Conclusions

CS remains an important determinant in the severity of AIS-DMVO. Collateral enhancement strategies may be a worthwhile pursuit in AIS-DMVO patients with more severe initial stroke presentation, which can be swiftly identified by the concise LAMS and serves as a proxy for underlying poor CS.

背景和目的：远端中血管闭塞（DMVO）是急性缺血性卒中（AIS）的重要诱因，而侧支状态（CS）在调节缺血性损伤进展中起着关键作用。我们旨在探讨与 AIS-DMVO 中 CS 相关的基线特征：本研究对前瞻性收集的数据库进行了回顾性分析，纳入了来自两家综合卒中中心的 130 名 AIS-DMVO 患者。收集了基线特征，包括患者人口统计学特征、入院时美国国立卫生研究院卒中量表（NIHSS）评分、入院时洛杉矶运动量表（LAMS）评分以及合并疾病，包括高血压、高脂血症、糖尿病、冠心病、心房颤动以及短暂性脑缺血发作或卒中病史。分析结果以低灌注指数比值（HIR）反映的良好 CS 为二分法：34%的患者CS良好。就闭塞位置而言，43.8%发生在M2近端，16.9%发生在M2中段，35.4%发生在更远端大脑中动脉，3.8%发生在远端大脑前动脉。在多变量逻辑分析中，较低的 NIHSS 评分和较低的 LAMS 评分均与良好的 CS 独立相关（比值比 [OR]：0.88，95% 置信区间 [CI]：0.82-0.95, p 结论：CS仍是决定AIS-DMVO严重程度的重要因素。对于初始卒中表现较严重的 AIS-DMVO 患者，侧支增强策略可能是一个值得追求的目标，简明的 LAMS 可以迅速识别侧支增强策略，并可作为潜在不良 CS 的替代指标。

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引用次数: 0

Validation of the transcranial Doppler rescue criteria for mechanical thrombectomy 验证机械血栓切除术的经颅多普勒抢救标准。

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-05-25 DOI: 10.1111/jon.13207

Adnan Khan, Maher Saqqur, Ashfaq Shuaib, Khurshid Khan, Vijay K. Sharma, Alejandro Brunser, Jürgen Eggers, Robert Mikulik, Aristeidis H. Katsanos, Theodore N. Sergentanis, Konstantinos Vadikolias, Marta Rubiera, Reza Bavarsad Shahripour, Huy Thang Nguyen, Patricia Martínez-Sánchez, Apostolos Safouris, Ioannis Heliopoulos, Abdul Salam, Carol Derksen, Konstantinos Voumvourakis, Theodora Psaltopoulou, Anne W. Alexandrov, Andrei V. Alexandrov, Georgios Tsivgoulis, CLOTBUST-PRO Investigators

Background and Purpose

Transcranial Doppler (TCD) identifies acute stroke patients with arterial occlusion where treatment may not effectively open the blocked vessel. This study aimed to examine the clinical utility and prognostic value of TCD flow findings in patients enrolled in a multicenter prospective study (CLOTBUST-PRO).

Methods

Patients enrolled with intracranial occlusion on computed tomography angiography (CTA) who underwent urgent TCD evaluation before intravenous thrombolysis was included in this analysis. TCD findings were assessed using the mean flow velocity (MFV) ratio, comparing the reciprocal ratios of the middle cerebral artery (MCA) depths bilaterally (affected MCA-to-contralateral MCA MFV [aMCA/cMCA MFV ratio]).

Results

A total of 222 patients with intracranial occlusion on CTA were included in the study (mean age: 64 ± 14 years, 62% men). Eighty-eight patients had M1 MCA occlusions; baseline mean National Institutes of Health Stroke Scale (NIHSS) score was 16, and a 24-hour mean NIHSS score was 10 points. An aMCA/cMCA MFV ratio of <.6 had a sensitivity of 99%, specificity of 16%, positive predictive value (PV) of 60%, and negative PV of 94% for identifying large vessel occlusion (LVO) including M1 MCA, terminal internal carotid artery, or tandem ICA/MCA. Thrombolysis in Brain Ischemia scale, with (grade ≥1) compared to without flow (grade 0), showed a sensitivity of 17.1%, specificity of 86.9%, positive PV of 62%, and negative PV of 46% for identifying LVO.

Conclusions

TCD is a valuable modality for evaluating arterial circulation in acute ischemic stroke patients, demonstrating significant potential as a screening tool for intravenous/intra-arterial lysis protocols.

背景和目的：经颅多普勒（TCD）可识别动脉闭塞的急性卒中患者，在这种情况下，治疗可能无法有效打通阻塞的血管。本研究旨在对参加多中心前瞻性研究（CLOTBUST-PRO）的患者的 TCD 血流检查结果的临床实用性和预后价值进行研究：分析对象包括计算机断层扫描血管造影（CTA）显示颅内闭塞的入组患者，这些患者在静脉溶栓前接受了紧急TCD评估。通过比较双侧大脑中动脉（MCA）深度的倒数比值（受累 MCA 与对侧 MCA MFV [aMCA/cMCA MFV 比值]），使用平均流速（MFV）比值对 TCD 结果进行评估：研究共纳入了 222 名 CTA 检查显示颅内闭塞的患者（平均年龄：64 ± 14 岁，62% 为男性）。88名患者为M1 MCA闭塞；美国国立卫生研究院卒中量表（NIHSS）基线平均评分为16分，24小时NIHSS平均评分为10分。aMCA/cMCA MFV 比值为结论：TCD 是评估急性缺血性卒中患者动脉循环的一种重要方式，作为静脉/动脉内溶栓方案的筛选工具具有巨大潜力。

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引用次数: 0

Longitudinal myelin content measures of slowly expanding lesions using 7T MRI in multiple sclerosis 利用 7T 磁共振成像测量多发性硬化症缓慢扩展病灶的纵向髓鞘含量。

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-05-22 DOI: 10.1111/jon.13209

Mina M. Huerta, Devon S. Conway, Sarah M. Planchon, Bhaskar Thoomukuntla, Oh Se-Hong, Ken E. Sakaie, Daniel Ontaneda, Kunio Nakamura

Background and Purpose

Slowly expanding lesions (SELs) are thought to represent a subset of chronic active lesions and have been associated with clinical disability, severity, and disease progression. The purpose of this study was to characterize SELs using advanced magnetic resonance imaging (MRI) measures related to myelin and neurite density on 7 Tesla (T) MRI.

Methods

The study design was retrospective, longitudinal, observational cohort with multiple sclerosis (n = 15). Magnetom 7T scanner was used to acquire magnetization-prepared 2 rapid acquisition gradient echo and advanced MRI including visualization of short transverse relaxation time component (ViSTa) for myelin, quantitative magnetization transfer (qMT) for myelin, and neurite orientation dispersion density imaging (NODDI). SELs were defined as lesions showing ≥12% of growth over 12 months on serial MRI. Comparisons of quantitative measures in SELs and non-SELs were performed at baseline and over time. Statistical analyses included two-sample t-test, analysis of variance, and mixed-effects linear model for MRI metrics between lesion types.

Results

A total of 1075 lesions were evaluated. Two hundred twenty-four lesions (21%) were SELs, and 216 (96%) of the SELs were black holes. At baseline, compared to non-SELs, SELs showed significantly lower ViSTa (1.38 vs. 1.53, p < .001) and qMT (2.47 vs. 2.97, p < .001) but not in NODDI measures (p > .27). Longitudinally, only ViSTa showed a greater loss when comparing SEL and non-SEL (p = .03).

Conclusions

SELs have a lower myelin content relative to non-SELs without a difference in neurite measures. SELs showed a longitudinal decrease in apparent myelin water fraction reflecting greater tissue injury.

背景和目的：缓慢扩展病变（SELs）被认为是慢性活动性病变的一个子集，与临床残疾、严重程度和疾病进展有关。本研究的目的是利用先进的磁共振成像（MRI）技术，通过7特斯拉（T）磁共振成像检查与髓鞘和神经元密度相关的指标来描述SEL的特征：研究设计为多发性硬化症患者（n = 15）的回顾性纵向观察队列。使用 Magnetom 7 T 扫描仪采集磁化准备 2 快速采集梯度回波和高级 MRI，包括髓鞘短横向弛豫时间分量可视化（ViSTa）、髓鞘定量磁化转移（qMT）和神经元定向弥散密度成像（NODDI）。SEL的定义是在连续核磁共振成像上显示12个月内增长≥12%的病变。对SEL和非SEL的定量指标进行基线和随时间变化的比较。统计分析包括双样本 t 检验、方差分析和病变类型间 MRI 指标的混合效应线性模型：共评估了 1075 个病灶。其中 224 个病灶（21%）为 SEL，216 个病灶（96%）为黑洞。基线时，与非 SEL 相比，SEL 的 ViSTa 明显较低（1.38 对 1.53，P.27）。纵向比较，SEL 与非 SEL 相比，只有 ViSTa 的损失更大（p = .03）：结论：SEL 相对于非 SEL 的髓鞘含量较低，但神经元测量结果没有差异。SEL的表观髓鞘水分率呈纵向下降趋势，反映出组织损伤更严重。

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引用次数: 0

Nerve cross-sectional area in advanced uremic neuropathy: A nerve ultrasound pilot study 晚期尿毒症神经病变的神经横截面积：神经超声试验研究

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-05-19 DOI: 10.1111/jon.13205

Jan-Hendrik Tosberg, Hannah Mork, Rafael Klimas, Jörg Radermacher, Peter Dieter Schellinger, Jörg Philipps

Background and Purpose

Uremic neuropathy (UN) is a disabling neuropathy in end-stage kidney disease (ESKD) affecting the majority of patients receiving long-term hemodialysis (HD). One previous nerve ultrasound study reported an increased cross-sectional area (CSA) of the median nerve in moderate UN, while another study found enlarged sural nerves in small-fiber polyneuropathy associated with ESKD. The present cohort study aims to analyze bilateral CSA of multiple nerves in UN.

Methods

Ten nondiabetic ESKD patients with UN on HD for at least 2 years and 10 healthy age-matched controls underwent bilateral ultrasound examinations with CSA measurements in 13 arm and leg nerve sites. Nerve conduction studies (NCS) and the total neuropathy score (TNS) were recorded. Pearson's coefficient and the Mann-Whitney U-test were used to analyze correlations and compare groups.

Results

ESKD patients presented advanced neuropathic symptoms (mean TNS 15.9). NCS showed significantly reduced motor and sensory amplitudes in the UN group compared to the control group, and a slightly reduced nerve CSA was observed in 5 of 13 nerve sites (p < .05); the other nerve sites were not enlarged. Sural nerve CSA (p < .05) and sensory amplitude (p < .01) were negatively correlated with the TNS.

Conclusions

Nerve enlargement was not observed in the present study in advanced UN. A reduced nerve CSA observed in the sural nerve suggests an axonal loss associated with long-term HD in ESKD. During clinical workup of an acute disease of the peripheral nervous system in ESKD patients, nerve enlargement might be attributable to other causes than chronic UN.

背景和目的：尿毒症神经病变（UN）是终末期肾病（ESKD）中的一种致残性神经病变，影响着大多数长期接受血液透析（HD）的患者。之前的一项神经超声研究报告称，中度尿毒症患者的正中神经横截面积（CSA）增大，而另一项研究则发现与 ESKD 相关的小纤维多发性神经病患者的鞍神经增大。本队列研究旨在分析 UN 多条神经的双侧 CSA：方法：10 名接受 HD 治疗至少 2 年的非糖尿病 ESKD UN 患者和 10 名年龄匹配的健康对照者接受了双侧超声波检查，测量了 13 个手臂和腿部神经部位的 CSA。记录了神经传导研究（NCS）和神经病变总分（TNS）。采用皮尔逊系数和曼-惠特尼 U 检验分析相关性并进行分组比较：结果：ESKD 患者出现晚期神经病理性症状（平均 TNS 15.9）。NCS 显示，与对照组相比，UN 组的运动和感觉振幅明显降低，在 13 个神经位点中的 5 个位点观察到神经 CSA 略有降低（p 结论：UN 组未观察到神经扩大：在本研究中，晚期 UN 未观察到神经扩张。在硬脊膜神经中观察到的神经CSA减少表明，ESKD患者的轴突损失与长期HD有关。在 ESKD 患者周围神经系统急性疾病的临床检查中，神经肿大可能是由慢性 UN 以外的其他原因引起的。

{"title":"Nerve cross-sectional area in advanced uremic neuropathy: A nerve ultrasound pilot study","authors":"Jan-Hendrik Tosberg, Hannah Mork, Rafael Klimas, Jörg Radermacher, Peter Dieter Schellinger, Jörg Philipps","doi":"10.1111/jon.13205","DOIUrl":"10.1111/jon.13205","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Purpose</h3>\u0000 \u0000 <p>Uremic neuropathy (UN) is a disabling neuropathy in end-stage kidney disease (ESKD) affecting the majority of patients receiving long-term hemodialysis (HD). One previous nerve ultrasound study reported an increased cross-sectional area (CSA) of the median nerve in moderate UN, while another study found enlarged sural nerves in small-fiber polyneuropathy associated with ESKD. The present cohort study aims to analyze bilateral CSA of multiple nerves in UN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten nondiabetic ESKD patients with UN on HD for at least 2 years and 10 healthy age-matched controls underwent bilateral ultrasound examinations with CSA measurements in 13 arm and leg nerve sites. Nerve conduction studies (NCS) and the total neuropathy score (TNS) were recorded. Pearson's coefficient and the Mann-Whitney <i>U</i>-test were used to analyze correlations and compare groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ESKD patients presented advanced neuropathic symptoms (mean TNS 15.9). NCS showed significantly reduced motor and sensory amplitudes in the UN group compared to the control group, and a slightly reduced nerve CSA was observed in 5 of 13 nerve sites (<i>p</i> < .05); the other nerve sites were not enlarged. Sural nerve CSA (<i>p</i> < .05) and sensory amplitude (<i>p</i> < .01) were negatively correlated with the TNS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Nerve enlargement was not observed in the present study in advanced UN. A reduced nerve CSA observed in the sural nerve suggests an axonal loss associated with long-term HD in ESKD. During clinical workup of an acute disease of the peripheral nervous system in ESKD patients, nerve enlargement might be attributable to other causes than chronic UN.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16399,"journal":{"name":"Journal of Neuroimaging","volume":"34 4","pages":"486-492"},"PeriodicalIF":2.3,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jon.13205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative brain stem assessment in discriminating neurodegenerative disorders from normal pressure hydrocephalus 脑干定量评估在区分神经退行性疾病和正常压力脑积水方面的作用

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-04-26 DOI: 10.1111/jon.13204

Charalampos Georgiopoulos, Stergios Papadimitriou, Dag Nyholm, Lena Kilander, Malin Löwenmark, David Fällmar, Johan Virhammar

Background and Purpose

Differentiating idiopathic normal pressure hydrocephalus (iNPH) from neurodegenerative disorders such as progressive supranuclear palsy (PSP), Multiple System Atrophy—parkinsonian type (MSA-P), and vascular dementia (VaD) is challenging due to overlapping clinical and neuroimaging findings. This study assesses if quantitative brain stem and cerebellum metrics can aid in this differentiation.

Methods

We retrospectively compared the sagittal midbrain area, midbrain to pons ratio, MR parkinsonism index (MRPI), and cerebellar atrophy in 30 PSP patients, 31 iNPH patients, 27 MSA-P patients, 32 VaD patients, and 25 healthy controls. Statistical analyses determined group differences, sensitivity, specificity, and the area under the receiver operating characteristic curves.

Results

There was an overlap in midbrain morphology between PSP and iNPH, as assessed with MRPI, midbrain to pons ratio, and midbrain area. A cutoff value of MRPI > 13 exhibited 84% specificity in distinguishing PSP from iNPH and 100% in discriminating PSP from all other conditions. A cutoff value of midbrain to pons ratio at <0.15 yielded 95% specificity for differentiating PSP from iNPH and 100% from all other conditions. A cutoff value of midbrain area at <87 mm² exhibited 97% specificity for differentiating PSP from iNPH and 100% from all other conditions. All measures showed low sensitivity. Cerebellar atrophy did not differ significantly among groups.

Conclusion

Our study questions MRPI's diagnostic performance in distinguishing PSP from iNPH. Simpler indices such as midbrain to pons ratio and midbrain area showed similar or better accuracy. However, all these indices displayed low sensitivity despite significant differences among PSP, MSA-P, and VaD.

背景和目的由于临床和神经影像学结果的重叠，将特发性正常压力脑积水（iNPH）与进行性核上性麻痹（PSP）、多系统萎缩-帕金森病型（MSA-P）和血管性痴呆（VaD）等神经退行性疾病区分开来具有挑战性。本研究评估了脑干和小脑的定量指标是否有助于这种区分。方法我们回顾性地比较了30名PSP患者、31名iNPH患者、27名MSA-P患者、32名VaD患者和25名健康对照者的中脑矢状面面积、中脑与脑桥比率、MR帕金森病指数（MRPI）和小脑萎缩情况。统计分析确定了组间差异、灵敏度、特异性和接收器操作特征曲线下面积。结果根据MRPI、中脑与脑桥比率和中脑面积评估，PSP和iNPH患者的中脑形态存在重叠。MRPI>13的临界值在区分PSP和iNPH方面显示出84%的特异性，在区分PSP和所有其他疾病方面显示出100%的特异性。中脑与脑桥比值的临界值为0.15时，区分PSP与iNPH的特异性为95%，区分PSP与所有其他病症的特异性为100%。中脑面积的临界值为87平方毫米，在鉴别PSP和iNPH方面的特异性为97%，在鉴别所有其他疾病方面的特异性为100%。所有测量指标的灵敏度都很低。结论我们的研究对 MRPI 在区分 PSP 和 iNPH 方面的诊断性能提出了质疑。中脑与脑桥比率和中脑面积等较简单的指标显示出相似或更好的准确性。然而，尽管 PSP、MSA-P 和 VaD 之间存在显著差异，但所有这些指标都显示出较低的灵敏度。

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引用次数: 0

Neural correlates of chocolate brand preference: A functional MRI study 巧克力品牌偏好的神经相关性：功能磁共振成像研究

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-04-26 DOI: 10.1111/jon.13203

Senal Peiris, Michael J. Tobia, Andrew Smith, Emily Grun, Rommy Elyan, Paul J. Eslinger, Qing X. Yang, Prasanna Karunanayaka

Background and Purpose

Preferences can be developed for, or against, specific brands and services. Using two functional magnetic resonance imaging (fMRI) experiments, this study investigated two dissociable aspects of reward processing, craving and liking, in chocolate lovers. The goal was to further delineate the neural basis supporting branding effects using familiar chocolate (FC) and unfamiliar chocolate (UC) brand images.

Methods

In the first experiment, subjects rated their subjective craving and liking on a scale of 1-5 (weak-strong) for each FC and UC image. In the second experiment, they performed a choice task between FC and UC images.

Results

Both the craving and liking ratings were significantly greater for FC and were differentially correlated with choice behavior. Craving ratings predicted greater preference for UC, and liking ratings predicted greater preference for FC. A contrast of neural activity for UC versus FC choice trials revealed significantly greater activation for UC choices in the bilateral inferior frontal gyrus and right caudate head. Response times for the FC images were faster than UC images; fMRI activity in the ventromedial prefrontal cortex was significantly correlated with response times during FC trials, but not UC trials. These correlations were significantly different from each other at the group level.

Conclusions

The choices for branded chocolate products are driven by higher subjective reward ratings and lower neural processing demands.

背景和目的人们可以对特定品牌和服务产生偏好，也可以对其产生反感。本研究利用两项功能磁共振成像（fMRI）实验，调查了巧克力爱好者在奖赏加工过程中的两个可分离的方面，即渴望和喜欢。目的是利用熟悉的巧克力（FC）和不熟悉的巧克力（UC）品牌图像，进一步阐明支持品牌效应的神经基础。方法在第一个实验中，受试者对每个 FC 和 UC 图像按 1-5 级（弱-强）评定其主观渴望和喜欢程度。第二项实验中，受试者在 FC 和 UC 图片之间进行选择。结果对 FC 的渴求度和好感度都明显更高，并且与选择行为有不同程度的相关性。渴求评分预示着对 UC 的偏好程度更高，而喜欢评分则预示着对 FC 的偏好程度更高。通过对比 UC 和 FC 选择试验的神经活动，发现在双侧额叶下回和右侧尾状脑中，UC 选择的激活程度明显更高。FC 图像的反应时间比 UC 图像快；腹内侧前额叶皮层的 fMRI 活动与 FC 试验中的反应时间显著相关，但与 UC 试验中的反应时间无关。结论对品牌巧克力产品的选择是由较高的主观奖励评级和较低的神经处理需求驱动的。

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引用次数: 0

Relationship between neuroimaging and cognition in frontotemporal dementia: An FDG-PET and structural MRI study 额颞叶痴呆症的神经影像与认知之间的关系：FDG-PET 和结构性 MRI 研究

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-04-26 DOI: 10.1111/jon.13206

Salih Cayir, Tommaso Volpi, Takuya Toyonaga, Jean-Dominique Gallezot, Yanghong Yang, Faranak Ebrahimian Sadabad, Tim Mulnix, Adam P. Mecca, Arman Fesharaki-Zadeh, David Matuskey

Background and Purpose

Frontotemporal dementia (FTD) is a clinically and pathologically heterogeneous neurodegenerative condition with a prevalence comparable to Alzheimer's disease for patients under 65 years of age. Limited studies have examined the association between cognition and neuroimaging in FTD using different imaging modalities.

Methods

We examined the association of cognition using Montreal Cognitive Assessment (MoCA) with both gray matter (GM) volume and glucose metabolism using magnetic resonance imaging and fluorodeoxyglucose (FDG)-PET in 21 patients diagnosed with FTD. Standardized uptake value ratio (SUVR) using the brainstem as a reference region was the primary outcome measure for FDG-PET. Partial volume correction was applied to PET data to account for disease-related atrophy.

Results

Significant positive associations were found between whole-cortex GM volume and MoCA scores (r = 0.46, p = .04). The association between whole-cortex FDG SUVR and MoCA scores was not significant (r = 0.37, p = .09). GM volumes of the frontal cortex (r = 0.54, p = .01), caudate (r = 0.62, p<.01), and insula (r = 0.57, p<.01) were also significantly correlated with MoCA, as were SUVR values of the insula (r = 0.51, p = .02), thalamus (r = 0.48, p = .03), and posterior cingulate cortex (PCC) (r = 0.47, p = .03).

Conclusions

Whole-cortex atrophy is associated with cognitive dysfunction, and this association is larger than for whole-cortex hypometabolism as measured with FDG-PET. At the regional level, focal atrophy and/or hypometabolism in the frontal cortex, insula, PCC, thalamus, and caudate seem to be important for the decline of cognitive function in FTD. Furthermore, these results highlight how functional and structural changes may not overlap and might contribute to cognitive dysfunction in FTD in different ways.

背景和目的额颞叶痴呆（FTD）是一种临床和病理上异质性的神经退行性疾病，在 65 岁以下的患者中发病率与阿尔茨海默病相当。我们在 21 名确诊为 FTD 的患者中使用蒙特利尔认知评估（MoCA）检查了认知能力与灰质（GM）体积和葡萄糖代谢之间的关系，并使用了磁共振成像和氟脱氧葡萄糖（FDG）-PET。以脑干为参考区域的标准化摄取值比（SUVR）是 FDG-PET 的主要结果测量指标。结果发现全皮层 GM 体积与 MoCA 评分之间存在显著的正相关（r = 0.46，p = .04）。整个皮层 FDG SUVR 与 MoCA 评分之间的关系不显著（r = 0.37，p = 0.09）。额叶皮层（r = 0.54，p = .01）、尾状核（r = 0.62，p<.01）和脑岛（r = 0.57，p<.01）的 GM 体积也与 MoCA 显著相关，脑岛（r = 0.51，p = .02）、丘脑（r = 0.48，p = .结论全皮层萎缩与认知功能障碍相关，而且这种相关性大于用 FDG-PET 测量的全皮层代谢低下。在区域水平上，额叶皮层、岛叶、丘脑PCC、丘脑和尾状体的局灶性萎缩和/或代谢低下似乎对FTD患者认知功能的下降很重要。此外，这些结果还突显了功能性和结构性变化可能并不重叠，而且可能以不同的方式导致 FTD 认知功能障碍。

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引用次数: 0

Feasibility of measuring blood-brain barrier permeability using ultra-short echo time radial magnetic resonance imaging 利用超短回波时间径向磁共振成像测量血脑屏障通透性的可行性

IF 2.4 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-04-14 DOI: 10.1111/jon.13199

Jonghyun Bae, Sawwal Qayyum, Jin Zhang, Ayesha Das, Isabel Reyes, Eric Aronowitz, Mihaela A. Stavarache, Michael G. Kaplitt, Arjun Masurkar, Sungheon Gene Kim

Background and Purpose

The purpose of this study is to evaluate the feasibility of using 3-dimensional (3D) ultra-short echo time (UTE) radial imaging method for measurement of the permeability of the blood-brain barrier (BBB) to gadolinium-based contrast agent. In this study, we propose to use the golden-angle radial sparse parallel (GRASP) method with 3D center-out trajectories for UTE, hence named as 3D UTE-GRASP. We first examined the feasibility of using 3D UTE-GRASP dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) for differentiating subtle BBB disruptions induced by focused ultrasound (FUS). Then, we examined the BBB permeability changes in Alzheimer's disease (AD) pathology using Alzheimer's disease transgenic mice (5xFAD) at different ages.

Methods

For FUS experiments, we used four Sprague Dawley rats at similar ages where we compared BBB permeability of each rat receiving the FUS sonication with different acoustic power (0.4-1.0 MPa). For AD transgenic mice experiments, we included three 5xFAD mice (6, 12, and 16 months old) and three wild-type mice (4, 8, and 12 months old).

Results

The result from FUS experiments showed a progressive increase in BBB permeability with increase of acoustic power (p < .05), demonstrating the sensitivity of DCE-MRI method for detecting subtle changes in BBB disruption. Our AD transgenic mice experiments suggest an early BBB disruption in 5xFAD mice, which is further impaired with aging.

Conclusion

The results in this study substantiate the feasibility of using the proposed 3D UTE-GRASP method for detecting subtle BBB permeability changes expected in neurodegenerative diseases, such as AD.

背景与目的本研究旨在评估使用三维超短回波时间（UTE）径向成像方法测量血脑屏障（BBB）对钆基造影剂通透性的可行性。在本研究中，我们建议将黄金角径向稀疏平行（GRASP）方法与三维中心输出轨迹用于 UTE，因此命名为三维 UTE-GRASP。我们首先研究了使用三维UTE-GRASP动态对比增强（DCE）-磁共振成像（MRI）区分聚焦超声（FUS）引起的细微BBB破坏的可行性。然后，我们利用不同年龄的阿尔茨海默病转基因小鼠（5xFAD）研究了阿尔茨海默病（AD）病理学中的 BBB 通透性变化。方法在 FUS 实验中，我们使用了四只年龄相仿的 Sprague Dawley 大鼠，比较了每只大鼠在接受不同声功率（0.4-1.0 MPa）的 FUS 声波治疗后的 BBB 通透性。结果FUS实验结果表明，随着声功率的增加，BBB通透性逐渐增加（p <.05），这证明了DCE-MRI方法在检测BBB破坏的细微变化方面的灵敏度。我们的 AD 转基因小鼠实验表明，5xFAD 小鼠的 BBB 早期破坏会随着年龄的增长而进一步受损。

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引用次数: 0

Annual Meeting of the American Society of Neuroimaging 美国神经成像学会年会

IF 2.4 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-04-12 DOI: 10.1111/jon.13202

引用次数: 0

Statin treatment intensity and cerebral vasomotor reactivity response in patients with ischemic stroke 他汀类药物治疗强度与缺血性脑卒中患者的脑血管运动反应性反应

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging

Pub Date : 2024-04-08 DOI: 10.1111/jon.13200

Behnam Sabayan, Amirhossein Akhavan Sigari, Royya Modir, Brett C. Meyer, Thomas Hemmen, Dawn Meyer, Reza Bavarsad Shahripour

Background and Purpose

Cerebral vasomotor reactivity (VMR) is vital for regulating brain blood flow and maintaining neurological function. Impaired cerebral VMR is linked to a higher risk of stroke and poor post-stroke outcomes. This study explores the relationship between statin treatment intensity and VMR in patients with ischemic stroke.

Methods

Seventy-four consecutive patients (mean age 69.3 years, 59.4% male) with recent ischemic stroke were included. VMR levels were assessed 4 weeks after the index stroke using transcranial Doppler, measuring the breath-holding index (BHI) as an indicator of the percentage increase in middle cerebral artery blood flow (higher BHI signifies higher VMR). Multistep multivariable regression models, adjusted for demographic and cerebrovascular risk factors, were employed to examine the association between statin intensity treatment and BHI levels.

Results

Forty-one patients (55%) received high-intensity statins. Patients receiving high-intensity statins exhibited a mean BHI of 0.85, whereas those on low-intensity statins had a mean BHI of 0.67 (mean difference 0.18, 95% confidence interval: 0.13-0.22, p-value<.001). This significant difference persisted in the fully adjusted model (adjusted mean values: 0.84 vs. 0.68, p-value: .008). No significant differences were observed in BHI values within patient groups on high-intensity or low-intensity statin therapy (all p-values>.05). Furthermore, no significant association was found between baseline low-density lipoprotein (LDL) levels and BHI.

Conclusions

High-intensity statin treatment post-ischemic stroke is linked to elevated VMR independent of demographic and clinical characteristics, including baseline LDL level. Further research is needed to explore statin therapy's impact on preserving brain vascular function beyond lipid-lowering effects.

背景和目的脑血管运动反应性（VMR）对调节脑血流和维持神经功能至关重要。脑血管运动反应性受损与中风风险升高和中风后预后不良有关。本研究探讨了他汀类药物治疗强度与缺血性脑卒中患者 VMR 之间的关系。方法连续纳入 74 名近期发生缺血性脑卒中的患者（平均年龄 69.3 岁，59.4% 为男性）。在中风发生 4 周后使用经颅多普勒评估 VMR 水平，测量屏气指数（BHI）作为大脑中动脉血流增加百分比的指标（BHI 越高表示 VMR 越高）。结果41名患者（55%）接受了高强度他汀类药物治疗。接受高强度他汀治疗的患者的平均 BHI 为 0.85，而接受低强度他汀治疗的患者的平均 BHI 为 0.67（平均差异为 0.18，95% 置信区间：0.13-0.22，P 值<.001）。在完全调整模型中，这一显著差异依然存在（调整后的平均值：0.84 vs. 0.68，p 值：.008）。在接受高强度或低强度他汀类药物治疗的患者组中，BHI 值无明显差异（所有 p 值均为 0.05）。结论缺血性卒中后高强度他汀治疗与 VMR 升高有关，与人口统计学和临床特征（包括基线低密度脂蛋白水平）无关。除降脂作用外，他汀类药物治疗对保护脑血管功能的影响还需进一步研究。

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引用次数: 0