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Retracted: Early Diagnosis of Breast Cancer Using Image Processing Techniques 撤下:利用图像处理技术早期诊断乳腺癌
4区 材料科学 Q2 Materials Science Pub Date : 2023-11-01 DOI: 10.1155/2023/9838616
Journal of Nanomaterials
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引用次数: 0
The Development of Eco-Friendly Biopolymers for Use in Tissue Engineering and Drug Delivery 用于组织工程和药物输送的生态友好型生物聚合物的发展
4区 材料科学 Q2 Materials Science Pub Date : 2023-10-31 DOI: 10.1155/2023/9270064
Md. Zobair Al Mahmud, Md. Didarul Islam, Md Hosne Mobarak
Tissue engineering and drug delivery have emerged as promising fields that hold the potential to revolutionize modern healthcare. The widespread use of synthetic polymers in these applications raises concerns about their environmental impact and biocompatibility. In response, researchers have shifted their focus toward the development of eco-friendly biopolymers as viable alternatives. This review paper aims to comprehensively analyze the progress made in the utilization of biopolymers for tissue engineering and drug delivery, with an emphasis on their ecological advantages and biomedical performance. The review begins by exploring the diverse sources of biopolymers, such as proteins, polysaccharides, and nucleic acids, derived from renewable resources, agricultural waste, etc. The discussion then delves into the unique properties of these biopolymers, including their biodegradability, nontoxic nature, and potential for controlled drug release. The incorporation of biopolymers in tissue engineering scaffolds is critically examined. The review also explores the role of biopolymers in the drug delivery systems, with a focus on nanoparticles, microparticles, hydrogels, and films. The capability of biopolymers to encapsulate and protect therapeutic agents, as well as their controlled release, is discussed in the context of targeted drug delivery and improved therapeutic outcomes. This paper highlights the challenges and future perspectives in the field of eco-friendly biopolymers for tissue engineering and drug delivery. Promising advancements in biofabrication techniques, nanotechnology, and personalized medicine are identified as key drivers for the rapid translation of these materials into the clinical applications. The development of eco-friendly biopolymers offers a sustainable and bio-safe alternative to the traditional synthetic polymers in tissue engineering and drug delivery. This comprehensive review underscores the crucial role of biopolymers in fostering advancements in regenerative medicine and therapeutic interventions while prioritizing environmental preservation and human health.
组织工程和药物输送已经成为有前途的领域,有可能彻底改变现代医疗保健。合成聚合物在这些应用中的广泛使用引起了对其环境影响和生物相容性的关注。作为回应,研究人员已将重点转向开发环保生物聚合物作为可行的替代品。本文综述了生物聚合物在组织工程和给药领域的应用进展,重点介绍了其生态优势和生物医学性能。本文首先探讨了从可再生资源、农业废弃物等中提取生物聚合物的多种来源,如蛋白质、多糖和核酸。然后深入讨论了这些生物聚合物的独特特性,包括它们的生物可降解性、无毒性和控制药物释放的潜力。生物聚合物在组织工程支架中的掺入被严格检查。本文还探讨了生物聚合物在药物传递系统中的作用,重点是纳米颗粒、微颗粒、水凝胶和膜。生物聚合物封装和保护治疗剂的能力,以及它们的控制释放,在靶向药物递送和改善治疗结果的背景下进行了讨论。本文重点介绍了用于组织工程和药物输送的生态友好型生物聚合物领域的挑战和未来前景。生物制造技术、纳米技术和个性化医疗的进步被认为是这些材料快速转化为临床应用的关键驱动因素。生态友好型生物聚合物的发展为传统的合成聚合物在组织工程和药物输送方面提供了一种可持续和生物安全的替代品。这篇综合综述强调了生物聚合物在促进再生医学和治疗干预方面的重要作用,同时优先考虑环境保护和人类健康。
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引用次数: 0
Silver Nanoparticles Biosynthesized Using Azadirachta indica Fruit and Leaf Extracts: Optimization, Characterization, and Anticancer Activity 利用印楝果和叶提取物生物合成纳米银:优化、表征和抗癌活性
4区 材料科学 Q2 Materials Science Pub Date : 2023-10-26 DOI: 10.1155/2023/9916777
Njud S. Alharbi, Nehad S. Alsubhi
Silver nanoparticles (AgNPs) are becoming increasingly important for various crucial applications, including antimicrobial, anticancer, catalytic, and anti-inflammatory. AgNPs biosynthesized from plant extracts have attracted considerable attention because of their eco-friendliness, simplicity, cost-effectiveness, and stability. This study investigated the potential of using fruit and leaf extracts of the medicinal plant Azadirachta indica as a capping and reducing agent for the biosynthesis of AgNPs. The size, shape, and optical properties of AgNPs significantly affect their chemical, physical, and biological activity. Therefore, this study optimized the biosynthesis conditions as a first attempt for A. indica fruit extracts to produce AgNPs with precise morphology. Subsequently, the biologically manufactured AgNPs were characterized using suitable techniques. Their potential anticancer activities were examined against in vitro human lung and breast cancer (H1975 and MCF-7) cell lines. The AgNPs were stable, with a high yield and a spherical shape, ranging in size from 14 to 19 nm and exhibiting an absorption band between 420 and 440 nm. The AgNPs biosynthesized using A. indica fruit and leaf extracts were shown to be highly toxic against in vitro H1975, with IC50 of 62.2 and 91 µg/mL, respectively. The IC50 values were 67.5 and 68.7 µg/mL when testing against the MCF-7 cells. These findings suggest that plant-derived nanoparticles have enormous potential for future biomedical applications, which warrants further investigation.
银纳米颗粒(AgNPs)在各种关键应用中变得越来越重要,包括抗菌、抗癌、催化和抗炎。植物提取物生物合成AgNPs因其生态友好、简单、经济、稳定等优点而受到广泛关注。本研究探讨了药用植物印楝果实和叶片提取物作为AgNPs生物合成的封顶和还原剂的潜力。AgNPs的大小、形状和光学性质显著影响其化学、物理和生物活性。因此,本研究优化了籼稻果实提取物的生物合成条件,为制备形态精确的AgNPs进行了首次尝试。随后,使用合适的技术对生物制造的AgNPs进行了表征。在体外对人肺癌和乳腺癌(H1975和MCF-7)细胞株进行了抑癌活性检测。制备的AgNPs结构稳定,产率高,呈球形,尺寸在14 ~ 19 nm之间,吸收带在420 ~ 440 nm之间。用籼稻果实和叶片提取物合成的AgNPs对体外H1975有高毒性,IC50分别为62.2和91µg/mL。对MCF-7细胞的IC50分别为67.5和68.7µg/mL。这些发现表明,植物源纳米颗粒在未来的生物医学应用中具有巨大的潜力,值得进一步研究。
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引用次数: 0
Retracted: Evaluation of Physicothermal Properties of Silicone Oil Dispersed with Multiwalled Carbon Nanotubes and Data Prediction Using ANN 多壁碳纳米管分散硅油的物理热性能评价及人工神经网络预测
4区 材料科学 Q2 Materials Science Pub Date : 2023-10-11 DOI: 10.1155/2023/9813208
Journal of Nanomaterials
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引用次数: 0
Retracted: Structural and Optical Properties of CdSe/CdTe Core-Shell Quantum Dots 撤下:CdSe/CdTe核壳量子点的结构和光学性质
4区 材料科学 Q2 Materials Science Pub Date : 2023-10-11 DOI: 10.1155/2023/9854379
Journal of Nanomaterials
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引用次数: 0
Retracted: Experimental Investigation of Spirulina Microalgae Biodiesel with Metal Nanoadditive on Single-Cylinder Diesel Engine 金属纳米添加剂在单缸柴油机上制备螺旋藻微藻生物柴油的实验研究
4区 材料科学 Q2 Materials Science Pub Date : 2023-10-11 DOI: 10.1155/2023/9756721
Journal of Nanomaterials
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引用次数: 0
Retracted: Nanometal-Based Magnesium Oxide Nanoparticle with C. vulgaris Algae Biodiesel in Diesel Engine 撤下:纳米金属基氧化镁纳米颗粒与C. vulgaris藻类在柴油发动机中的应用
4区 材料科学 Q2 Materials Science Pub Date : 2023-10-11 DOI: 10.1155/2023/9861247
Journal of Nanomaterials
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引用次数: 0
Toxicity of Silver Nanoparticles Synthesized from Opuntia ficus-indica on Danio rerio and Arabidopsis thaliana and Their Antimicrobial Activity 无花果机会合成银纳米颗粒对水稻和拟南芥的毒性及抑菌活性研究
4区 材料科学 Q2 Materials Science Pub Date : 2023-10-05 DOI: 10.1155/2023/6903787
Mariana Georgina Muñoz-Carrillo, Cristina Garcidueñas-Piña, Melannie Montserrat Pedroza-Jimenez, Roberto Carlos Valerio-García, Ana Laura Carbajal-Hernández, Galdino Andrade, José Francisco Morales-Dominguez
Silver nanoparticles (AgNPs) usefulness has been widely demonstrated in fields such as agriculture, medicine, food, and pharmaceutical industries, primarily for their antibacterial properties. AgNPs synthesized from biological extracts are as effective as those obtained by chemical methods, with the advantage that in the former fewer toxic compounds are generated for the environment. In a previous work, we synthesized AgNPs from the aqueous extract of Opuntia ficus-indica fruit peel (OfAgNPs) and tested their activity against microorganisms from a wastewater treatment plant. OfAgNPs were proposed for use as tertiary wastewater treatment; however, more needs to be known about their antimicrobial activity and toxicological potential. In the present study, the antimicrobial effect of OfAgNPs was demonstrated against reference bacterial strains of Escherichia coli (DH5α), Pseudomonas aeruginosa (ATCC 27853), and Staphylococcus aureus (ATCC 29213), and against fungi isolated in the laboratory and identified as Aspergillus sp., Colletotrichum sp., and Cladosporium sp. In addition, in this work, we report the effects of OfAgNPs produced by exposure in two model organisms: a fish, Danio rerio, and a plant, Arabidopsis thaliana. OfAgNPs in A. thaliana caused negative effects on growth and photosynthetic pigment content only when the exposure was constant and greater than 6 mg/L. However, in D. rerio, impaired caudal fin development was observed at 0.15 mg/L from 24 hr of exposure. This is evidence of the toxicological potential of OfAgNPs, so their use should be carried out in a controlled manner.
银纳米粒子(AgNPs)的用途在农业、医药、食品和制药工业等领域得到了广泛的证明,主要是因为它们的抗菌特性。由生物提取物合成的AgNPs与通过化学方法获得的AgNPs一样有效,其优点是前者对环境产生的有毒化合物较少。在之前的研究中,我们从无花果皮的水提取物中合成了AgNPs (OfAgNPs),并测试了它们对废水处理厂微生物的活性。建议将agnps用于三级污水处理;然而,它们的抗菌活性和毒理学潜力还有待进一步了解。在本研究中,我们证实了OfAgNPs对大肠杆菌(DH5α)、铜绿假单胞菌(ATCC 27853)和金黄色葡萄球菌(ATCC 29213)的抑菌作用,以及对实验室分离的真菌(鉴定为曲霉、炭疽杆菌和枝孢杆菌)的抑菌作用。此外,在本研究中,我们报道了暴露在两种模式生物(鱼、丹尼奥里奥和植物、拟南芥)中产生的OfAgNPs的作用。当暴露量大于6 mg/L时,对拟南芥的生长和光合色素含量产生负影响。然而,在暴露于0.15 mg/L 24小时后,观察到d.r ereio尾鳍发育受损。这是OfAgNPs毒理学潜力的证据,因此它们的使用应以受控的方式进行。
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引用次数: 0
Assessment on the Toxic Effects of Chemically Synthesized SPIONs against Model Organisms 化学合成SPIONs对模式生物的毒性作用评价
4区 材料科学 Q2 Materials Science Pub Date : 2023-09-19 DOI: 10.1155/2023/4235308
Chellapan Justin, Antony V. Samrot, Nagarajan Shobana, Mahendran Sathiyasree, Subramanian Saigeetha, Rajan Renuka Remya, Deenadhayalan Rajalakshmi, S. Prasath
The remarkable physicochemical properties of nanomaterials have attracted researchers due to the numerous applications in the field of chemistry, biology, and physics. Despite the various applications, superparamagnetic iron oxide nanoparticles (SPIONs) are harmful to living organisms and to the environment as they are released without any safety testing. In this study, SPIONs were synthesized and further characterized. The aim of the study was to examine the toxicity of synthesized SPIONs against animal models: Zebrafish—Danio rerio, Earthworm—Eudrilus eugeniae, and Drosophila—Drosophila melanogaster through histology using Hematoxylin–Eosin and Prussian Blue staining. The accumulation of SPIONs was further quantified by using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Through histology images, it was observed that the SPIONs had caused damages and a lower concentration of 0.001–0.002 μg/ml of metal accumulation was detected in the ICP-MS analysis.
纳米材料以其卓越的物理化学特性在化学、生物学和物理学等领域有着广泛的应用,吸引了众多研究人员的关注。尽管有各种各样的应用,超顺磁性氧化铁纳米颗粒(SPIONs)在未经任何安全测试的情况下被释放,对生物和环境有害。本研究合成了SPIONs并对其进行了进一步的表征。采用苏木精-伊红染色和普鲁士蓝染色,观察合成SPIONs对斑马鱼-斑马鱼、蚯蚓-尤金线虫和果蝇-黑腹果蝇的组织学毒性。利用电感耦合等离子体质谱(ICP-MS)进一步定量SPIONs的积累。通过组织学观察发现,SPIONs已造成损伤,ICP-MS检测到低浓度的0.001 ~ 0.002 μg/ml的金属积累。
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引用次数: 0
Elucidating the Role of Plant Extracts Mediated Gold Nanoparticles as Smart Antimicrobials: Two-Way Attack 阐明植物提取物介导的金纳米颗粒作为智能抗菌剂的作用:双向攻击
4区 材料科学 Q2 Materials Science Pub Date : 2023-08-10 DOI: 10.1155/2023/4085090
A. Balkrishna, Akansha Rohela, Ashwani Kumar, Shalini Mishra, V. Arya, Vandana Kala, Naveen Thakur, Nikesh Thakur, A. Kumari, N. Khan
Pathogenic bacteria remain the primary health concern even after developing a broad spectrum of antibiotics. The emergence of drug-resistant strains increased mortality, perhaps resulting in a never-ending future pandemic. The researchers are currently concentrating their efforts on nanotechnology-based therapies to counteract resistance. The present review focuses on the antimicrobial characteristics of plant-mediated gold nanoparticles (Au NPs). First, the methodology and importance of green synthesis are highlighted. Variability in NPs characterization methods was identified, with dynamic light scattering, zeta potential, and thermogravimetric analysis limited to a few investigations. Second, the Au NPs synthesized using different plant extracts were found to be broad-spectrum antimicrobial agents against Pseudomonas aeruginosa, Escherichia coli, Cryptococcus neoformans, Candida glabrata, Aspergillus niger, etc. The lowest minimum inhibitory concentrations range (1.95–15.62 µg/mL) was observed with Au NPs synthesized using Thymus vulgaris extract against Staphylococcus aureus, P. aeruginosa, Bacillus subtilis, and E. coli. The effect was more pronounced with smaller NPs (<10 nm). The activity of Au NPs might be mediated through a two-way attack which includes nanoparticles’ diverse mechanisms like reactive oxygen species generation, etc., and surface-attached phytocompounds such as flavonoids, alkaloids, phenolics, terpenoids, tannins, etc. The futuristic role of nanotechnology-based interventions in managing microbial infections is imperative. Synergistic interactions of Au NPs with antibiotics, toxicity profiling, stability, and bioavailability could be major areas of NPs research.
即使在开发了广谱抗生素之后,致病菌仍然是主要的健康问题。耐药菌株的出现增加了死亡率,可能导致未来永无止境的大流行。研究人员目前正集中精力研究基于纳米技术的疗法来对抗耐药性。本文综述了植物介导的金纳米颗粒(Au NPs)的抗菌特性。首先,强调了绿色合成的方法和重要性。鉴定了NPs表征方法的可变性,动态光散射、zeta势和热重分析仅限于少数研究。其次,利用不同植物提取物合成的Au NPs对铜绿假单胞菌、大肠杆菌、新型隐球菌、光秃假丝酵母、黑曲霉等具有广谱抗菌作用。普通胸腺提取物合成的Au NPs对金黄色葡萄球菌、铜绿假单胞菌、枯草芽孢杆菌和大肠杆菌的最低抑制浓度范围为1.95 ~ 15.62µg/mL。NPs越小(<10 nm),效果越明显。Au NPs的活性可能是通过双向攻击介导的,双向攻击包括纳米颗粒的活性氧生成等多种机制,以及表面附着的植物化合物如黄酮类、生物碱、酚类、萜类、单宁等。基于纳米技术的干预措施在管理微生物感染方面的未来作用是必不可少的。Au NPs与抗生素的协同相互作用、毒性分析、稳定性和生物利用度可能是NPs研究的主要领域。
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引用次数: 3
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Journal of Nanomaterials
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