A 68-year-old patient had, for about 7 months, in the right buttock, a nodule of about 2 cm in diameter, rosy colour, centrally ulcerated, of hard consistency, asymptomatic. Histological examination and immunohistochemical investigations deposed for the diagnosis of granular cell tumour (Abrikosoff tumour). Granular cell tumour is a neoplasm in most cases benign, characterised by voluminous cells with eosinophilic cytoplasm and grainy appearance, with the granules corresponding to lysosomes. It is currently considered a variant of schwannoma, although cases with different histogenesis have been described. This tumour, most frequently localised on the dorsal surface of the tongue, very rarely affects the skin
{"title":"Abrikosoff’s Tumor: A Case Repor","authors":"De Giacomo Pierfrancesco","doi":"10.23880/cdoaj-16000304","DOIUrl":"https://doi.org/10.23880/cdoaj-16000304","url":null,"abstract":"A 68-year-old patient had, for about 7 months, in the right buttock, a nodule of about 2 cm in diameter, rosy colour, centrally ulcerated, of hard consistency, asymptomatic. Histological examination and immunohistochemical investigations deposed for the diagnosis of granular cell tumour (Abrikosoff tumour). Granular cell tumour is a neoplasm in most cases benign, characterised by voluminous cells with eosinophilic cytoplasm and grainy appearance, with the granules corresponding to lysosomes. It is currently considered a variant of schwannoma, although cases with different histogenesis have been described. This tumour, most frequently localised on the dorsal surface of the tongue, very rarely affects the skin","PeriodicalId":164845,"journal":{"name":"Clinical Dermatology Open Access Journal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132869354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fatal Hepatitis Associated with Nivolumab and Ipilimumab Combination Therapy in the Patient with Malignant Melanoma","authors":"Y. Kato","doi":"10.23880/cdoaj-16000262","DOIUrl":"https://doi.org/10.23880/cdoaj-16000262","url":null,"abstract":"","PeriodicalId":164845,"journal":{"name":"Clinical Dermatology Open Access Journal","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122347755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vitiligo area severity index (VASI) is formulated as one of the successful tools used in dermatology to calculate the area of vitiligo which is gauged in hand units. Since the patches of vitiligo have irregular outlines with varying sizes in same patient, the accuracy of using hand units is still debated. Various methods have arrived in measuring the area of Vitiligo, but none prove precision for research purpose. Hence we extrapolate the “point-counting method” with the formula to calculate area of an irregular surface thus aiding in area calculation for statistical purpose.
{"title":"Vitiligo Area Assessment by Manual Planimetry for Statistical Precision","authors":"Kachhawa D","doi":"10.23880/cdoaj-16000241","DOIUrl":"https://doi.org/10.23880/cdoaj-16000241","url":null,"abstract":"Vitiligo area severity index (VASI) is formulated as one of the successful tools used in dermatology to calculate the area of vitiligo which is gauged in hand units. Since the patches of vitiligo have irregular outlines with varying sizes in same patient, the accuracy of using hand units is still debated. Various methods have arrived in measuring the area of Vitiligo, but none prove precision for research purpose. Hence we extrapolate the “point-counting method” with the formula to calculate area of an irregular surface thus aiding in area calculation for statistical purpose.","PeriodicalId":164845,"journal":{"name":"Clinical Dermatology Open Access Journal","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122523164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Melasma is an acquired hypermelanosis characterized by symmetrical, irregular light-to-dark-brown macules & patches on sun-exposed area, especially on the face. Tranexamic acid is a plasmin inhibitor which inhibits UV induced plasmin activity & subsequently reduces melanogenesis in melanocyte. Ascorbic acid affects the monopherase activity of tyrosinase thus reducing melanin synthesis. In addition, ascorbic acid has a photoprotective effect, preventing the absorption of ultraviolet radiation (UVA &UVB). The aim of this study is to evaluate & compare the clinical efficacy plus adverse effects of topical tranexamic acid and topical Ascorbic acid in the treatment of melasma. Materials and Methods: A total of fifty eight (58) Egyptian female patients are enrolled in this study. This is left-right randomized clinical trial. The total duration of the study was 12 weeks. At baseline, a photo will be taken and the patients will be instructed to use, at night, a wet dressing using TA solution (3 ampoules, total 15 ml of Tranexamic Acid® (500 mg/5 ml), was applied on the left side of the face. and Ascorbic acid cream once daily on the right side of the face. Results: We found no statistical significance differences between Rt side (Ascorbic acid treated side) and Lt side (Tranexamic acid treated side) in MASI score at any times of treatment also there were no statistical significance differences between them in % of change in MASI score. Regarding change in the same side there were statistical significant reduction in MASI score in both Rt side (Ascorbic acid treated side) and Lt side (Tranexamic acid treated side). Side effects were burning sensation and erythema which subside quickly on both sides.
{"title":"Topical Tranexamic Acid Versus Topical Ascorbic Acid in the Treatment of Melasma: Randomized Clinical Trial","authors":"A. A.","doi":"10.23880/cdoaj-16000192","DOIUrl":"https://doi.org/10.23880/cdoaj-16000192","url":null,"abstract":"Background: Melasma is an acquired hypermelanosis characterized by symmetrical, irregular light-to-dark-brown macules & patches on sun-exposed area, especially on the face. Tranexamic acid is a plasmin inhibitor which inhibits UV induced plasmin activity & subsequently reduces melanogenesis in melanocyte. Ascorbic acid affects the monopherase activity of tyrosinase thus reducing melanin synthesis. In addition, ascorbic acid has a photoprotective effect, preventing the absorption of ultraviolet radiation (UVA &UVB). The aim of this study is to evaluate & compare the clinical efficacy plus adverse effects of topical tranexamic acid and topical Ascorbic acid in the treatment of melasma. Materials and Methods: A total of fifty eight (58) Egyptian female patients are enrolled in this study. This is left-right randomized clinical trial. The total duration of the study was 12 weeks. At baseline, a photo will be taken and the patients will be instructed to use, at night, a wet dressing using TA solution (3 ampoules, total 15 ml of Tranexamic Acid® (500 mg/5 ml), was applied on the left side of the face. and Ascorbic acid cream once daily on the right side of the face. Results: We found no statistical significance differences between Rt side (Ascorbic acid treated side) and Lt side (Tranexamic acid treated side) in MASI score at any times of treatment also there were no statistical significance differences between them in % of change in MASI score. Regarding change in the same side there were statistical significant reduction in MASI score in both Rt side (Ascorbic acid treated side) and Lt side (Tranexamic acid treated side). Side effects were burning sensation and erythema which subside quickly on both sides.","PeriodicalId":164845,"journal":{"name":"Clinical Dermatology Open Access Journal","volume":"183 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121946867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cutaneous Dissemination of Herpes Simplex Virus: A Complication of Hailey-Hailey Disease","authors":"Gramp P","doi":"10.23880/cdoaj-16000254","DOIUrl":"https://doi.org/10.23880/cdoaj-16000254","url":null,"abstract":"","PeriodicalId":164845,"journal":{"name":"Clinical Dermatology Open Access Journal","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132154070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syringoma is often localized to the face. The aim of this work is to describe the first case of female genital syringoma observed in Bangui. Miss B, aged 19 years old, living in Bangui, consulted on September 13, 2019 for a genital pruritis. There is a history of carcinoma in her older sister. The physical examination shows a general good condition, elastic vulvar edema with a rash of small papules. The hypotheses of early condyloma and syringoma have been raised. The histology result is in favor of a syringoma. The patient was proposed for medical evacuation to a country with Laser. This case, which is the first in Bangui, should lead clinicians to think of syringoma when faced with a papular genital rash
{"title":"Women's Eruptive Genital Syringoma: A Case Observed at the Dermatology-Venerology Department of the National Hospital University Center of Bangui, Central African Republic","authors":"K. L","doi":"10.23880/cdoaj-16000250","DOIUrl":"https://doi.org/10.23880/cdoaj-16000250","url":null,"abstract":"Syringoma is often localized to the face. The aim of this work is to describe the first case of female genital syringoma observed in Bangui. Miss B, aged 19 years old, living in Bangui, consulted on September 13, 2019 for a genital pruritis. There is a history of carcinoma in her older sister. The physical examination shows a general good condition, elastic vulvar edema with a rash of small papules. The hypotheses of early condyloma and syringoma have been raised. The histology result is in favor of a syringoma. The patient was proposed for medical evacuation to a country with Laser. This case, which is the first in Bangui, should lead clinicians to think of syringoma when faced with a papular genital rash","PeriodicalId":164845,"journal":{"name":"Clinical Dermatology Open Access Journal","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127324081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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