Pub Date : 2021-09-30DOI: 10.47363/jnsrr/2021(3)122
B. Prajapati, Umang Varia
Respiratory diseases are a common disease with high incidence all over the world, pose a serious threat to human health and are considered to be an economic and social burden. The application of nanotechnology in drug delivery systems has created new treatments for respiratory diseases. In this regard, this review has systematically introduced the physicochemical properties of nanoparticles (NP). We have reviewed the current state of research on various Nano carriers in the treatment of respiratory diseases, including liposomes, solid lipid Nano carriers, and polymer Nano carriers. The application of nanotechnology overcomes some of the deficiencies inherent in drugs and offers endless possibilities for the development of drugs for the treatment of respiratory diseases. However, most of the relevant research is in the preclinical stage and the assessment of safety remains a difficult task. Future research is needed to focus on changes in the performance, molecular mechanisms, and potential toxicity of therapeutic Nano medicines.
{"title":"Nano Science in Pulmonary Drug Delivery","authors":"B. Prajapati, Umang Varia","doi":"10.47363/jnsrr/2021(3)122","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)122","url":null,"abstract":"Respiratory diseases are a common disease with high incidence all over the world, pose a serious threat to human health and are considered to be an economic and social burden. The application of nanotechnology in drug delivery systems has created new treatments for respiratory diseases. In this regard, this review has systematically introduced the physicochemical properties of nanoparticles (NP). We have reviewed the current state of research on various Nano carriers in the treatment of respiratory diseases, including liposomes, solid lipid Nano carriers, and polymer Nano carriers. The application of nanotechnology overcomes some of the deficiencies inherent in drugs and offers endless possibilities for the development of drugs for the treatment of respiratory diseases. However, most of the relevant research is in the preclinical stage and the assessment of safety remains a difficult task. Future research is needed to focus on changes in the performance, molecular mechanisms, and potential toxicity of therapeutic Nano medicines.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":"184 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80480980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jnsrr/2021(3)120
N. Omer
Hybrid smart materials, frame both inorganic and organic components, and their contribution in the designing of specific modern technologies are receiving more attention and interest due to their better improved solution process, controllable synthesis, and tunable chemical roperties. However, the focus problem of compatibility, solubility and aggregation is to be solved urgently, which inevitably limits them widely application. To this end, an inorganic–organic hybrid material with wide-band absorption is designed and prepared, that incorporates octavinyl-polyhedral oligomeric silsesquioxane (OV-POSS)with aminecontaining and cyan uric chloride (CC) to get our novel system OV-POSS-Amine-CC our structure, composition, and properties were characterized and evaluated, the system was prepared as anew path to synthesis novel enhanced hybrid to applied in many application.
{"title":"Organic Inorganic Materials Open New Path for Synthesis and Application","authors":"N. Omer","doi":"10.47363/jnsrr/2021(3)120","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)120","url":null,"abstract":"Hybrid smart materials, frame both inorganic and organic components, and their contribution in the designing of specific modern technologies are receiving more attention and interest due to their better improved solution process, controllable synthesis, and tunable chemical roperties. However, the focus problem of compatibility, solubility and aggregation is to be solved urgently, which inevitably limits them widely application. To this end, an inorganic–organic hybrid material with wide-band absorption is designed and prepared, that incorporates octavinyl-polyhedral oligomeric silsesquioxane (OV-POSS)with aminecontaining and cyan uric chloride (CC) to get our novel system OV-POSS-Amine-CC our structure, composition, and properties were characterized and evaluated, the system was prepared as anew path to synthesis novel enhanced hybrid to applied in many application.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73545532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-30DOI: 10.47363/jnsrr/2021(3)121
B. Najafov, FP Abasov, RS Ibragimov, Baku c Azadlig Ave. Russia Industry
In the work of the various parameters studied film amorphous and nano-crystalline alloy silicon-carbon (а-nc-Si1-xCx :H (x=0÷1)) doped with phosphorus (PH3 ) and boron (B2 H6 ). Studied the properties of these films on different substrates derived from quartz, glass and Silicon-coated Fe, Al, Pd, Ni, Ti, Ag. Using transmission electron microscopy (TEM) studied the morphology obtained nano tubes. Also examine the structural properties of films by using infrared spectroscopy and x-ray diffraction of x-rays. Created by cascade solar cells area S = 1.2 cm2 and have a coefficient of 11.2%.
在各种参数的工作下，研究了掺杂磷(PH3)和硼(B2 H6)的薄膜非晶和纳米晶合金硅碳(nc- si - xcx:H (x=0÷1))。研究了这些薄膜在石英、玻璃和硅包覆Fe、Al、Pd、Ni、Ti、Ag等不同基底上的性能。利用透射电子显微镜(TEM)研究所得纳米管的形貌。同时用红外光谱和x射线衍射法检查薄膜的结构特性。由级联太阳能电池产生，面积S = 1.2平方厘米，系数为11.2%。
{"title":"Obtaining Thin Films of Silicon-Carbon Method of Reactive Magnetron Sputtering are used as Solar Cells","authors":"B. Najafov, FP Abasov, RS Ibragimov, Baku c Azadlig Ave. Russia Industry","doi":"10.47363/jnsrr/2021(3)121","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)121","url":null,"abstract":"In the work of the various parameters studied film amorphous and nano-crystalline alloy silicon-carbon (а-nc-Si1-xCx :H (x=0÷1)) doped with phosphorus (PH3 ) and boron (B2 H6 ). Studied the properties of these films on different substrates derived from quartz, glass and Silicon-coated Fe, Al, Pd, Ni, Ti, Ag. Using transmission electron microscopy (TEM) studied the morphology obtained nano tubes. Also examine the structural properties of films by using infrared spectroscopy and x-ray diffraction of x-rays. Created by cascade solar cells area S = 1.2 cm2 and have a coefficient of 11.2%.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80856302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-31DOI: 10.47363/jnsrr/2021(3)118
Rc Jagessar
Nonotechanology has been a rapidly growing field of advanced science at the inception of this century. Many problematic endeavours in sciences have been successfully overcome using nanoparticles. For example, a low risk solution using antibody modified bismuth nanoparticle, in combination with an X-ray dose equivalent to a chest X-ray specifically, has been shown to kill the common bacterium Pseudomonas aeruginosa in a set up designed to resemble a deep wound in human tissue. Nanosized gold particle could catalyse the oxidation of carbon monoxide better than anything previously known. Heparin functionalized nanoparticles have been use for targeted delivery of anti-malarial drugs. Heparin is abundant and cheap compared to treatments that involve antibodies, an important consideration, since malaria is most common in developing countries. A bone repairing nano-particle paste has been developed that promises faster repair of fractures and breakages. DNA containing two growth genes is encapsulated inside synthetic calcium phosphate nanoparticles. In a remarkable demonstration of the extreme limits of nanoscale engineering, researchers have used the tip of a scanning tunnelling microscope to cleave and form selected chemical bonds in a complex molecule. Many medicinal and industrial endeavours have seen the use of Nanotechnology. These and other more recent advances in nanotechnology will be presented at this conference
{"title":"Nanotechnology and Nanoparticles in Contemporary Sciences","authors":"Rc Jagessar","doi":"10.47363/jnsrr/2021(3)118","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)118","url":null,"abstract":"Nonotechanology has been a rapidly growing field of advanced science at the inception of this century. Many problematic endeavours in sciences have been successfully overcome using nanoparticles. For example, a low risk solution using antibody modified bismuth nanoparticle, in combination with an X-ray dose equivalent to a chest X-ray specifically, has been shown to kill the common bacterium Pseudomonas aeruginosa in a set up designed to resemble a deep wound in human tissue. Nanosized gold particle could catalyse the oxidation of carbon monoxide better than anything previously known. Heparin functionalized nanoparticles have been use for targeted delivery of anti-malarial drugs. Heparin is abundant and cheap compared to treatments that involve antibodies, an important consideration, since malaria is most common in developing countries. A bone repairing nano-particle paste has been developed that promises faster repair of fractures and breakages. DNA containing two growth genes is encapsulated inside synthetic calcium phosphate nanoparticles. In a remarkable demonstration of the extreme limits of nanoscale engineering, researchers have used the tip of a scanning tunnelling microscope to cleave and form selected chemical bonds in a complex molecule. Many medicinal and industrial endeavours have seen the use of Nanotechnology. These and other more recent advances in nanotechnology will be presented at this conference","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75562245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-31DOI: 10.47363/JNSRR/2020(2)114
Prathima Prabhu Tumkur, Nicole Nazario Bayon, N. Gunasekaran, B. Lamani, K. Prabhakaran, Joseph C. Hall, G. Ramesh
In the present study, cellulose nanoparticles were synthesized from waste cotton by acid hydrolysis method. Nanoparticles were obtained by the hydrolysis of pretreated cotton fibers with an acid mixture containing water, hydrochloric acid (HCl) and sulphuric acid (H2SO4). Characterization and biocompatibility studies of obtained cellulose nanoparticles were performed successfully. The morphological studies of cellulose nanoparticles were conducted by Field Emission Scanning Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM). Both showed that the cellulose nanoparticles synthesized from waste cotton measured approximately 100 - 200nm in diameter. Energy Dispersive X-ray Spectroscopic spectrum showed the elemental composition of the cellulose nanoparticles containing carbon and oxygen. Fourier Transform Infrared (FT-IR) spectroscopy spectrum revealed the presence of several characteristic peaks of cellulose nanoparticles. Human lung epithelial (Beas-2B) cells were used to assess the cytotoxicity and biocompatibility activity of cellulose nanoparticles. Cytotoxicity of cellulose nanoparticles was determined by 3-(4,5- Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. Live/Dead viability assay was carried out to assess the biocompatibility of cellulose nanoparticles. Generation of Reactive Oxygen Species in Beas-2B cells incubated with cellulose nanoparticles was determined by Reactive Oxygen Species (ROS) assay. MTT and Live/Dead assays showed no significant induction of cell death even at higher concentrations (100 μg) upon exposure to Beas- 2B cells. ROS assay revealed that cellulose nanoparticles did not induce any reactive oxygen species that contribute to the oxidative stress and inflammation leading to various disease conditions. The results revealed that the cellulose nanoparticles have a great potential in a variety of commercial applications
{"title":"Evaluation of Cellulose Nanoparticles Synthesized by Acid Hydrolysis for Safe Applications","authors":"Prathima Prabhu Tumkur, Nicole Nazario Bayon, N. Gunasekaran, B. Lamani, K. Prabhakaran, Joseph C. Hall, G. Ramesh","doi":"10.47363/JNSRR/2020(2)114","DOIUrl":"https://doi.org/10.47363/JNSRR/2020(2)114","url":null,"abstract":"In the present study, cellulose nanoparticles were synthesized from waste cotton by acid hydrolysis method. Nanoparticles were obtained by the hydrolysis of pretreated cotton fibers with an acid mixture containing water, hydrochloric acid (HCl) and sulphuric acid (H2SO4). Characterization and biocompatibility studies of obtained cellulose nanoparticles were performed successfully. The morphological studies of cellulose nanoparticles were conducted by Field Emission Scanning Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM). Both showed that the cellulose nanoparticles synthesized from waste cotton measured approximately 100 - 200nm in diameter. Energy Dispersive X-ray Spectroscopic spectrum showed the elemental composition of the cellulose nanoparticles containing carbon and oxygen. Fourier Transform Infrared (FT-IR) spectroscopy spectrum revealed the presence of several characteristic peaks of cellulose nanoparticles. Human lung epithelial (Beas-2B) cells were used to assess the cytotoxicity and biocompatibility activity of cellulose nanoparticles. Cytotoxicity of cellulose nanoparticles was determined by 3-(4,5- Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. Live/Dead viability assay was carried out to assess the biocompatibility of cellulose nanoparticles. Generation of Reactive Oxygen Species in Beas-2B cells incubated with cellulose nanoparticles was determined by Reactive Oxygen Species (ROS) assay. MTT and Live/Dead assays showed no significant induction of cell death even at higher concentrations (100 μg) upon exposure to Beas- 2B cells. ROS assay revealed that cellulose nanoparticles did not induce any reactive oxygen species that contribute to the oxidative stress and inflammation leading to various disease conditions. The results revealed that the cellulose nanoparticles have a great potential in a variety of commercial applications","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83477305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-31DOI: 10.47363/JNSRR/2020(2)104
Sara Khelf, Leila Guedjali, S. Haddad, D. Satta
Breast cancer (CS) is the most common female cancer worldwide, ranking first in Algeria for its frequency and mortality .Molecular classification has distinguished at least four molecular types: luminal A, luminal B, HER2 and basal-like. Our objective is to study the phenotypic profile of breast cancer in women with cancer as well as the different clinical, immunohistochemical and therapeutic aspects of different molecular groups.We undertook a retrospective study between October 2016 and December 2017. This study involved 121 files. The distribution of the population according to age showed that the most affected age group is [53-63] years old with 35%. Molecular classification results showed that the most common type was luminal A at 37.19%, followed by luminal type B at 27.27%, basal-like at 19.83%, and HER2 at 15.70%. Breast cancer of luminal type, expressing[ ER], accounts for 70 to 80% of all mammary carcinomas and that the luminal group A is the most common with proportions of 58 , 5% and 54.3% respectively while the distinction is observed in the other groups. Molecular classification plays a very important role in the treatment. This result shows that luminal type A is the most common, and that postmenopausal women are most likely to have breast cancer. This classification is very important in the orientation of the treatment. The resulting molecular classification is expected to better classify tumors to a personalized therapy. Breast cancer, molecular classification, immunohistochemistry, hormone receptors, HER2 status
乳腺癌(CS)是世界范围内最常见的女性癌症，其发病率和死亡率在阿尔及利亚排名第一。分子分类已区分出至少四种分子类型:luminal A, luminal B, HER2和basal-like。我们的目的是研究女性乳腺癌的表型特征，以及不同分子群的不同临床、免疫组织化学和治疗方面的差异。我们在2016年10月至2017年12月期间进行了回顾性研究。这项研究涉及121个文件。人群按年龄分布情况显示，受影响最大的年龄组为[53-63]，占35%。分子分类结果显示，最常见的类型为管腔A型(37.19%)，其次为管腔B型(27.27%)、基底样型(19.83%)和HER2型(15.70%)。表达[ER]的管腔型乳腺癌占所有乳腺癌的70 - 80%，其中以管腔A组最为常见，分别为58.5%和54.3%，而其他组之间存在差异。分子分类在治疗中起着非常重要的作用。这一结果表明，腔型A是最常见的，绝经后妇女最容易患乳腺癌。这种分类对于治疗的方向是非常重要的。由此产生的分子分类有望更好地对肿瘤进行个性化治疗。乳腺癌，分子分类，免疫组织化学，激素受体，HER2状态
{"title":"Molecular Classification of Breast Cancer in the Region of Constantine: An Epidemiological Study","authors":"Sara Khelf, Leila Guedjali, S. Haddad, D. Satta","doi":"10.47363/JNSRR/2020(2)104","DOIUrl":"https://doi.org/10.47363/JNSRR/2020(2)104","url":null,"abstract":"Breast cancer (CS) is the most common female cancer worldwide, ranking first in Algeria for its frequency and mortality .Molecular classification has distinguished at least four molecular types: luminal A, luminal B, HER2 and basal-like. Our objective is to study the phenotypic profile of breast cancer in women with cancer as well as the different clinical, immunohistochemical and therapeutic aspects of different molecular groups.We undertook a retrospective study between October 2016 and December 2017. This study involved 121 files. The distribution of the population according to age showed that the most affected age group is [53-63] years old with 35%. Molecular classification results showed that the most common type was luminal A at 37.19%, followed by luminal type B at 27.27%, basal-like at 19.83%, and HER2 at 15.70%. Breast cancer of luminal type, expressing[ ER], accounts for 70 to 80% of all mammary carcinomas and that the luminal group A is the most common with proportions of 58 , 5% and 54.3% respectively while the distinction is observed in the other groups. Molecular classification plays a very important role in the treatment. This result shows that luminal type A is the most common, and that postmenopausal women are most likely to have breast cancer. This classification is very important in the orientation of the treatment. The resulting molecular classification is expected to better classify tumors to a personalized therapy. Breast cancer, molecular classification, immunohistochemistry, hormone receptors, HER2 status","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74836544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-31DOI: 10.47363/jnsrr/2019(1)102
A. Belousov
This scientific article is devoted to the study of the effect of magnetite nanoparticles (MCS-B brand) on the functional platelets activity of human. 0.9% NaCl was used as a control. The results of the study showed that the use of NaCl saline solution shifts the colloidal suspension equilibrium of platelets towards a significant (P<0.001) increase in the rate and index of their aggregation. For the first time, the effect of 0.9% NaCl on function of platelets makes us reconsider the concept of safety of infusion solutions in patients with initial signs of platelet disorders hemostasis. On the contrary, the use of MCS-B nanoparticles significantly revealed (P<0.05) an increase in the stability of colloidal suspension of platelets. This is an important pathogenetic factor which affects the occurrence of correction of hemostasis in conditions of blood clotting disorders
{"title":"Study of the Effect of Nanotechnology Drugs (mcs-b) on the Aggregation of Human Blood Platelets","authors":"A. Belousov","doi":"10.47363/jnsrr/2019(1)102","DOIUrl":"https://doi.org/10.47363/jnsrr/2019(1)102","url":null,"abstract":"This scientific article is devoted to the study of the effect of magnetite nanoparticles (MCS-B brand) on the functional platelets activity of human. 0.9% NaCl was used as a control. The results of the study showed that the use of NaCl saline solution shifts the colloidal suspension equilibrium of platelets towards a significant (P<0.001) increase in the rate and index of their aggregation. For the first time, the effect of 0.9% NaCl on function of platelets makes us reconsider the concept of safety of infusion solutions in patients with initial signs of platelet disorders hemostasis. On the contrary, the use of MCS-B nanoparticles significantly revealed (P<0.05) an increase in the stability of colloidal suspension of platelets. This is an important pathogenetic factor which affects the occurrence of correction of hemostasis in conditions of blood clotting disorders","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80562347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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