Pub Date : 2023-09-30DOI: 10.47363/jnsrr/2023(5)153
R C Jagessar
Porphyrins are terapyrrolic compounds that are usually synthesized by the condensation of aromatic aldehyde with pyrrole or the reaction of dipyrromethene with an aromatic aldehyde followed by oxidation with p-chloranil.
卟啉是三吡咯类化合物，通常由芳香醛与吡咯缩合或二吡咯甲烷与芳香醛反应，然后与对氯胺氧化合成。
{"title":"Porphyrins based Nanomaterials, the Future of Science","authors":"R C Jagessar","doi":"10.47363/jnsrr/2023(5)153","DOIUrl":"https://doi.org/10.47363/jnsrr/2023(5)153","url":null,"abstract":"Porphyrins are terapyrrolic compounds that are usually synthesized by the condensation of aromatic aldehyde with pyrrole or the reaction of dipyrromethene with an aromatic aldehyde followed by oxidation with p-chloranil.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135037708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-30DOI: 10.47363/jnsrr/2023(5)154
Sharon Kiprotich
Zinc telluride (ZnTe) quantum dots (QDs) prepared via a facile one-pot synthetic route is hereby reported. Zinc acetate, l-cysteine and potassium telluride were utilized as the starting materials for synthesis under low growth temperature (90oC) in open air conditions.
{"title":"Synthesis and Characterization of Zinc Telluride Quantum Dots: Studies on the Structural and Optical Properties","authors":"Sharon Kiprotich","doi":"10.47363/jnsrr/2023(5)154","DOIUrl":"https://doi.org/10.47363/jnsrr/2023(5)154","url":null,"abstract":"Zinc telluride (ZnTe) quantum dots (QDs) prepared via a facile one-pot synthetic route is hereby reported. Zinc acetate, l-cysteine and potassium telluride were utilized as the starting materials for synthesis under low growth temperature (90oC) in open air conditions.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135037710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.47363/jnsrr/2022(4)130
Jagessar Rc
Nanotechnology has indeed fulfill many roles in many fields in contemporary science, such as electronic and IT applications, medical and health care applications, including COVID-19, Energy applications, environmental remediation, nanocomposites, herbal nano-particles. Research in this field needs to further proliferate, because of the novel properties of nano-based materials. Nanotechnology, will continue to solve many technologically driven process in contemporary science. It remains the vision of contemporary nanotechnologist to proliferate this research to other dimensions such as finding a cure for COVID-19. Nanotechnology/nanoparticles is the way forward to neutralize and eradicate SARS-COV-2 virus. Nanoparticles are of the same dimension as the SARS-COV-2 virus and thus this will promote effective interaction with the virus. Research in this area is continually increasing. In addition, a relatively large number of nanomolecules can be in effective contact with the virus of nanodimensions. Of greater significance, the use of plant extracts in synthesis of plant based nanoparticles to eradicate the viruses because of their easier synthesis, environmentally friendly nature and superior nature, as selective plants possess antiviral activities on their own.
{"title":"Nanotechnology and Treatment of Covid-19","authors":"Jagessar Rc","doi":"10.47363/jnsrr/2022(4)130","DOIUrl":"https://doi.org/10.47363/jnsrr/2022(4)130","url":null,"abstract":"Nanotechnology has indeed fulfill many roles in many fields in contemporary science, such as electronic and IT applications, medical and health care applications, including COVID-19, Energy applications, environmental remediation, nanocomposites, herbal nano-particles. Research in this field needs to further proliferate, because of the novel properties of nano-based materials. Nanotechnology, will continue to solve many technologically driven process in contemporary science. It remains the vision of contemporary nanotechnologist to proliferate this research to other dimensions such as finding a cure for COVID-19. Nanotechnology/nanoparticles is the way forward to neutralize and eradicate SARS-COV-2 virus. Nanoparticles are of the same dimension as the SARS-COV-2 virus and thus this will promote effective interaction with the virus. Research in this area is continually increasing. In addition, a relatively large number of nanomolecules can be in effective contact with the virus of nanodimensions. Of greater significance, the use of plant extracts in synthesis of plant based nanoparticles to eradicate the viruses because of their easier synthesis, environmentally friendly nature and superior nature, as selective plants possess antiviral activities on their own.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90163167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.47363/jnsrr/2022(4)131
T. Lee, E. Chang
Molybdenum disulfide (MoS2 ) transistors are emerging as an exciting material system for future electronics due to their unique electrical properties, twodimensional (2D) nature and atomically thin geometry. This ultra-thin-body (UTB) semiconductor considerably reduces current leakage and enables gate-to-channel control. The homogeneous growth of sub-10 nm dielectrics on 2D materials remains challenging. We demonstrate high-performance MoS2 FETs at low temperature (150°C) using the plasma-enhanced Atomic layer deposition (PEALD) technique. The device exhibits a high on/off current ratio of about 106 , the field-effect mobility of 9.5 cm2 /Vs, and a subthreshold swing (SS) of 171 mV/dec, which is comparable to the similar structure of the top gate device. In addition, we have demonstrated contact resistance on back-gate MoS2 FETs with and without dielectric capping
{"title":"Improved Performance of MoS2 FETs using AlN/Al2 O3 dielectric and Plasma Enhanced Atomic Layer Deposition (PEALD)","authors":"T. Lee, E. Chang","doi":"10.47363/jnsrr/2022(4)131","DOIUrl":"https://doi.org/10.47363/jnsrr/2022(4)131","url":null,"abstract":"Molybdenum disulfide (MoS2 ) transistors are emerging as an exciting material system for future electronics due to their unique electrical properties, twodimensional (2D) nature and atomically thin geometry. This ultra-thin-body (UTB) semiconductor considerably reduces current leakage and enables gate-to-channel control. The homogeneous growth of sub-10 nm dielectrics on 2D materials remains challenging. We demonstrate high-performance MoS2 FETs at low temperature (150°C) using the plasma-enhanced Atomic layer deposition (PEALD) technique. The device exhibits a high on/off current ratio of about 106 , the field-effect mobility of 9.5 cm2 /Vs, and a subthreshold swing (SS) of 171 mV/dec, which is comparable to the similar structure of the top gate device. In addition, we have demonstrated contact resistance on back-gate MoS2 FETs with and without dielectric capping","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83011836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jnsrr/2021(3)126
V. Zaichick
Thyroid adenomas (TA) are benign tumors, but there is a 20% possibility of malignant transformation. The distinguishing between the TA and thyroid cancer (TC) is tricky, therefore new TA biomarkers are needed. Furthermore, the role of trace elements (TE) in etiology and pathogenesis of TA is unclear. The aim of this exploratory study was to examine the content of bromine (Br), cooper (Cu), iron (Fe), rubidium (Rb), strontium (Sr), and zinc (Zn) in the normal and in adenomatous thyroid. Thyroid tissue levels of six TE were prospectively evaluated in 19 patients with TA and 105 healthy inhabitants. Measurements were performed using 109Cd radionuclide-induced energy-dispersive X-ray fluorescent analysis Tissue samples were divided into two portions. One was used for morphological study while the other was intended for TE analysis. It was found that contents of Br and Cu were significantly higher (25.8 and 4.16 times, respectively) and content of Sr were significantly lower (39%) in adenomatous thyroid in comparison with normal level. There are considerable changes in TE contents in the adenomatous thyroid.
{"title":"Evaluation of Trace Elements in Thyroid Adenomas Using Energy Dispersive X-Ray Fluorescent Analysis","authors":"V. Zaichick","doi":"10.47363/jnsrr/2021(3)126","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)126","url":null,"abstract":"Thyroid adenomas (TA) are benign tumors, but there is a 20% possibility of malignant transformation. The distinguishing between the TA and thyroid cancer (TC) is tricky, therefore new TA biomarkers are needed. Furthermore, the role of trace elements (TE) in etiology and pathogenesis of TA is unclear. The aim of this exploratory study was to examine the content of bromine (Br), cooper (Cu), iron (Fe), rubidium (Rb), strontium (Sr), and zinc (Zn) in the normal and in adenomatous thyroid. Thyroid tissue levels of six TE were prospectively evaluated in 19 patients with TA and 105 healthy inhabitants. Measurements were performed using 109Cd radionuclide-induced energy-dispersive X-ray fluorescent analysis Tissue samples were divided into two portions. One was used for morphological study while the other was intended for TE analysis. It was found that contents of Br and Cu were significantly higher (25.8 and 4.16 times, respectively) and content of Sr were significantly lower (39%) in adenomatous thyroid in comparison with normal level. There are considerable changes in TE contents in the adenomatous thyroid.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81070838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jnsrr/2021(3)128
Jafarli Rufat
We have explored various solution- processing techniques to produce ZnS thin films on conducting (ITO) and silicon substrates along with ZnS-porous silicon composite films. All these samples obtained from different methods and chemical recipes were annealed under fixed ambient conditions and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and ultraviolet photocurrent response. Various characterizations reveal that the fabrication conditions and intrinsic defects of ZnS play a vital role in optoelectronic performance.
{"title":"Photoconductivity of ZnS Thin Films Deposited by Solution-Processing Techniques","authors":"Jafarli Rufat","doi":"10.47363/jnsrr/2021(3)128","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)128","url":null,"abstract":"We have explored various solution- processing techniques to produce ZnS thin films on conducting (ITO) and silicon substrates along with ZnS-porous silicon composite films. All these samples obtained from different methods and chemical recipes were annealed under fixed ambient conditions and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and ultraviolet photocurrent response. Various characterizations reveal that the fabrication conditions and intrinsic defects of ZnS play a vital role in optoelectronic performance.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88620236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jnsrr/2021(3)127
Jafarli Rufat
Semiconducting ZnS1-xFex thin films were prepared with different substrate temperature on glass substrates from aqueous solution technique. ZnS1-xFex films were prepared, using a aqueous solution containing ethyleneglycol, zinc chloride and sulphur. XRD study shows that the aqueous deposited ZnS1-xFex thin films are polycrystalline hexagonal structure. The effect of Fe concentration on the optical parameters such as absorption coefficient, refractive index, dielectric function, optical conductivity, and reflectivity is also investigated. Results revealed that Cd1-xFexS is a suitable compound for spintronics and optoelectronics devices. A good optical transparency of about 75% in the visible region is observed for all prepared ZnS1-xFex thin films. The direct optical band gap of the deposited ZnS1-xFex thin films with different substrate temperature (380°C – 530°C) were lying in the range 3.27–3.35 eV.
{"title":"Properties of ZnS1-xFe x thin Films Deposited","authors":"Jafarli Rufat","doi":"10.47363/jnsrr/2021(3)127","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)127","url":null,"abstract":"Semiconducting ZnS1-xFex thin films were prepared with different substrate temperature on glass substrates from aqueous solution technique. ZnS1-xFex films were prepared, using a aqueous solution containing ethyleneglycol, zinc chloride and sulphur. XRD study shows that the aqueous deposited ZnS1-xFex thin films are polycrystalline hexagonal structure. The effect of Fe concentration on the optical parameters such as absorption coefficient, refractive index, dielectric function, optical conductivity, and reflectivity is also investigated. Results revealed that Cd1-xFexS is a suitable compound for spintronics and optoelectronics devices. A good optical transparency of about 75% in the visible region is observed for all prepared ZnS1-xFex thin films. The direct optical band gap of the deposited ZnS1-xFex thin films with different substrate temperature (380°C – 530°C) were lying in the range 3.27–3.35 eV.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85242198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.47363/jnsrr/2021(3)125
Rc Jagessar
Carbon nanotubes often refer to single-wall carbon nanotubes (SWCNTs) with diameters in the range of a nanometer. Single-wall carbon nanotubes are one of the allotropes of carbon, intermediate between fullerene cages and flat graphene. Carbon nanotubes also often refer to multi-wall carbon nanotubes(MWCNTs), consisting of nested single-wall carbon nanotubes, weakly bound together by van der Waals interactions in a tree ring-like structure. If not identical, these tubes are very similar to long straight and parallel carbon layers, cylindrically arranged around a hollow tube. Multi-wall carbon nanotubes are also sometimes used to refer to double and triple wall carbon nanotubes. Carbon nanotubes can also refer to tubes with an undetermined carbon wall structure and diameters less than 100 nanometers. While nanotubes of other compositions exist, most research has been focused on the carbon ones. The length of a carbon nanotube produced by common production methods is typically much larger than its diameter. Thus, for many purposes, end effects are neglected and the length of carbon nanotubes is assumed infinite. Carbon nanotubes can exhibit remarkable unique properties. These include electrical conductivity, while others are semiconductors. They also have exceptional tensile strengthand thermal conductivity, because of their nanostructure and strength of the bonds between carbon atoms. In addition, they can be chemically modified. Thus, due to their variable, unique properties, carbon nanotubes have found applications in many realms such as electronics, optics, composite materials nanotechnology, and other applications of materials science. In addition, carbon nanotubes can be integrated into other molecules to form novel structures with unique properties, different from the individual reactants. These unique products have also found application in many realms of nanotechnology
{"title":"Carbon Nanotubes and its Application in Nanotechnology","authors":"Rc Jagessar","doi":"10.47363/jnsrr/2021(3)125","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)125","url":null,"abstract":"Carbon nanotubes often refer to single-wall carbon nanotubes (SWCNTs) with diameters in the range of a nanometer. Single-wall carbon nanotubes are one of the allotropes of carbon, intermediate between fullerene cages and flat graphene. Carbon nanotubes also often refer to multi-wall carbon nanotubes(MWCNTs), consisting of nested single-wall carbon nanotubes, weakly bound together by van der Waals interactions in a tree ring-like structure. If not identical, these tubes are very similar to long straight and parallel carbon layers, cylindrically arranged around a hollow tube. Multi-wall carbon nanotubes are also sometimes used to refer to double and triple wall carbon nanotubes. Carbon nanotubes can also refer to tubes with an undetermined carbon wall structure and diameters less than 100 nanometers. While nanotubes of other compositions exist, most research has been focused on the carbon ones. The length of a carbon nanotube produced by common production methods is typically much larger than its diameter. Thus, for many purposes, end effects are neglected and the length of carbon nanotubes is assumed infinite. Carbon nanotubes can exhibit remarkable unique properties. These include electrical conductivity, while others are semiconductors. They also have exceptional tensile strengthand thermal conductivity, because of their nanostructure and strength of the bonds between carbon atoms. In addition, they can be chemically modified. Thus, due to their variable, unique properties, carbon nanotubes have found applications in many realms such as electronics, optics, composite materials nanotechnology, and other applications of materials science. In addition, carbon nanotubes can be integrated into other molecules to form novel structures with unique properties, different from the individual reactants. These unique products have also found application in many realms of nanotechnology","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80340400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.47363/jnsrr/2021(3)124
S. Varshney, N. S. Satheesh Madhav
Aim: Isolation of novel biopolymer from Arachis hypogea seeds to be used as bio-excipient in formulation of nanosized Topiramate loaded bio-flexy films for epilepsy treatment. Method: Formulations containing nanosized Topiramate: Arachis hypogea biopolymer (in ratios of 1:0.5, 1:1; 1:3, 1:5, 1:6, 1:10) (FAO1-FAO6) were prepared by solvent casting method. Results: Arachis Hypogea Biopolymer showed percentage yield of 20% ±0.01. The biopolymer was brown in color, odourless, partially soluble in water. Its colour changing point was found to be 210ºC±2. It was tested positive for proteins and carbohydrates, amino acids were not present. Evaluation parameters of nanosized Topiramate loaded bio-flexy films containing Arachis hypogea biopolymer (FAO1-FAO6) revealed Thickness: 0.022 mm±0.004 to 0.044±0.003 mm, Folding Endurance: 140-169, Surface pH: 7.01±0.03 to 7.01±0.02, Weight Uniformity: 0.006±0.04 to 0.036±0.02, Drug Content Uniformity: 85.4%±0.68 to 93.4%±0.50, Swelling Percentage: 73%±0.6 to 89%±0.4, Percentage Moisture Uptake (PTU): 1.8%±0.10 to 2.4%±0.08, Mucoadhesion time: 45-150 minutes, Mucoretention time: 75-210 minutes. The drug release pattern for formulations FAO1-FAO6 containing Arachis hypogea biopolymer based on the T50% and T80% was found to be FAO2 (1:1) > FAO5 (1:6) > FAO6 (1:10) > FAO1 (1:0.5)> FAO4 (1:5) > FAO3 (1:3). Conclusion: Based on all above-mentioned evaluation parameters, FAO2 (containing Topiramate: Arachis hypogea biopolymer (1:1)) Bio-flexy film having R2 =0.9215, Higuchi Matrix as best fit model, follows Fickian Diffusion (Higuchi Matrix) release mechanism, T50%: 44.52 hrs., T80%: 46.14 hrs. using BITS Software. Stability study revealed stable formulations. Isolated Arachis hypogea biopolymer showed in-built filmability, mucoadhesivity properties, was non-reactive and suitable for Soft Palatal Drug Delivery.
{"title":"Smart Mucoadhesive Film Former from Seeds of Arachis Hypogea and Its In-Built Properties for Pharmaceutical Applications","authors":"S. Varshney, N. S. Satheesh Madhav","doi":"10.47363/jnsrr/2021(3)124","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)124","url":null,"abstract":"Aim: Isolation of novel biopolymer from Arachis hypogea seeds to be used as bio-excipient in formulation of nanosized Topiramate loaded bio-flexy films for epilepsy treatment. Method: Formulations containing nanosized Topiramate: Arachis hypogea biopolymer (in ratios of 1:0.5, 1:1; 1:3, 1:5, 1:6, 1:10) (FAO1-FAO6) were prepared by solvent casting method. Results: Arachis Hypogea Biopolymer showed percentage yield of 20% ±0.01. The biopolymer was brown in color, odourless, partially soluble in water. Its colour changing point was found to be 210ºC±2. It was tested positive for proteins and carbohydrates, amino acids were not present. Evaluation parameters of nanosized Topiramate loaded bio-flexy films containing Arachis hypogea biopolymer (FAO1-FAO6) revealed Thickness: 0.022 mm±0.004 to 0.044±0.003 mm, Folding Endurance: 140-169, Surface pH: 7.01±0.03 to 7.01±0.02, Weight Uniformity: 0.006±0.04 to 0.036±0.02, Drug Content Uniformity: 85.4%±0.68 to 93.4%±0.50, Swelling Percentage: 73%±0.6 to 89%±0.4, Percentage Moisture Uptake (PTU): 1.8%±0.10 to 2.4%±0.08, Mucoadhesion time: 45-150 minutes, Mucoretention time: 75-210 minutes. The drug release pattern for formulations FAO1-FAO6 containing Arachis hypogea biopolymer based on the T50% and T80% was found to be FAO2 (1:1) > FAO5 (1:6) > FAO6 (1:10) > FAO1 (1:0.5)> FAO4 (1:5) > FAO3 (1:3). Conclusion: Based on all above-mentioned evaluation parameters, FAO2 (containing Topiramate: Arachis hypogea biopolymer (1:1)) Bio-flexy film having R2 =0.9215, Higuchi Matrix as best fit model, follows Fickian Diffusion (Higuchi Matrix) release mechanism, T50%: 44.52 hrs., T80%: 46.14 hrs. using BITS Software. Stability study revealed stable formulations. Isolated Arachis hypogea biopolymer showed in-built filmability, mucoadhesivity properties, was non-reactive and suitable for Soft Palatal Drug Delivery.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77929685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-30DOI: 10.47363/jnsrr/2021(3)123
Vikram B. Madane, N. Aloorkar, V. Mokale
Niosomes are a non-ionic spherical surfactant that is biodegradable, non-toxic, more durable, and cost effective as compare to liposomes. Through niosomes delivery of both hydrophilic and liophilic drug can be achieve very constructively. To achieve targeted drug delivery, drug binds to receptor site and then we can get the therapeutic action without attaching to other sites to prevent the undesirable or side effect of active pharmaceutical ingredient to the systemic circulation, hence niosomes is a very novel drug delivery system by which we can achieve very safe drug delivery at the site of action needed with high efficacy. In this review paper we try to compile all the information related with niosomes like introduction, structure, composition advantages, types, disadvantage, preparation methods, factor affecting, evaluation studies, applications of niosomes, difference between liposomes and niosomes, current available marketed formulation and patents, final conclusion and at last future perspective of niosomes.
{"title":"Niosomes As an Ideal Drug Delivery System","authors":"Vikram B. Madane, N. Aloorkar, V. Mokale","doi":"10.47363/jnsrr/2021(3)123","DOIUrl":"https://doi.org/10.47363/jnsrr/2021(3)123","url":null,"abstract":"Niosomes are a non-ionic spherical surfactant that is biodegradable, non-toxic, more durable, and cost effective as compare to liposomes. Through niosomes delivery of both hydrophilic and liophilic drug can be achieve very constructively. To achieve targeted drug delivery, drug binds to receptor site and then we can get the therapeutic action without attaching to other sites to prevent the undesirable or side effect of active pharmaceutical ingredient to the systemic circulation, hence niosomes is a very novel drug delivery system by which we can achieve very safe drug delivery at the site of action needed with high efficacy. In this review paper we try to compile all the information related with niosomes like introduction, structure, composition advantages, types, disadvantage, preparation methods, factor affecting, evaluation studies, applications of niosomes, difference between liposomes and niosomes, current available marketed formulation and patents, final conclusion and at last future perspective of niosomes.","PeriodicalId":16545,"journal":{"name":"Journal of Nanosciences Research & Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86135719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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