Alessandra Laís Pinho Valente Pires, Adriana Mendonça da Silva, Murilo Cruz, Ynara Bosco de Oliveira Lima-Arsati, Franco Arsati, Rodrigo Tripodi Calumby, Jean Nunes dos Santos, Gabriela Botelho Martins, Valéria Souza Freitas
Objective
To estimate the network structure of 21 symptoms of anxiety and depression in individuals diagnosed with oral lichen planus (OLP) and compare it with salivary biomarkers, cortisol and alpha-amylase.
Materials and Methods
A case–control study was conducted with 21 OLP cases and 21 controls matched by sex and age. Beck Anxiety and Depression Inventories were administered, and salivary cortisol and alpha-amylase levels were determined. Descriptive analysis used the Mann–Whitney U test to compare participants' responses and the Benjamini-Hochberg Method to control the False Discovery Rate (FDR). Network analysis was performed using regularized partial correlation network models.
Results
A significant association was found between anxiety (p = 0.001) and depression (p = 0.004) scores and OLP. The “shaky/unsteady” symptom was most central in the anxiety network for OLP patients, while “feelings of punishment” and “self-criticism” were central in the depression network. Weak correlations were observed between cortisol and alpha-amylase in anxiety and depressive symptoms. Cortisol awekening response (CAR) had a negative correlation with alpha-amylase awakening response (AAR) (−0.54), as like AAR and Faint/lightheaded (−0.57) in anxiety network. Anxiety network structures did not differ between groups (p = 0.18), but the depression network was more connected in controls than in OLP cases (overall strength 69.29 vs. 27.35, p < 0.000).
Conclusion
This study reveals the distinct network structures of anxiety and depression symptoms in OLP patients, highlighting a new methodological approach to exploring symptom configurations. When exploring the relationship with cortisol and alpha-amylase, weak relationships were found between them. The findings may prompt further network studies involving biomarkers and their interaction with anxiety and depression.
{"title":"Network Analysis of Anxiety and Depression Symptoms in Individuals With Oral Lichen Planus and Evaluation of Salivary Biomarkers: A New Approach","authors":"Alessandra Laís Pinho Valente Pires, Adriana Mendonça da Silva, Murilo Cruz, Ynara Bosco de Oliveira Lima-Arsati, Franco Arsati, Rodrigo Tripodi Calumby, Jean Nunes dos Santos, Gabriela Botelho Martins, Valéria Souza Freitas","doi":"10.1111/jop.70038","DOIUrl":"10.1111/jop.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To estimate the network structure of 21 symptoms of anxiety and depression in individuals diagnosed with oral lichen planus (OLP) and compare it with salivary biomarkers, cortisol and alpha-amylase.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A case–control study was conducted with 21 OLP cases and 21 controls matched by sex and age. Beck Anxiety and Depression Inventories were administered, and salivary cortisol and alpha-amylase levels were determined. Descriptive analysis used the Mann–Whitney U test to compare participants' responses and the Benjamini-Hochberg Method to control the False Discovery Rate (FDR). Network analysis was performed using regularized partial correlation network models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant association was found between anxiety (<i>p</i> = 0.001) and depression (<i>p</i> = 0.004) scores and OLP. The “shaky/unsteady” symptom was most central in the anxiety network for OLP patients, while “feelings of punishment” and “self-criticism” were central in the depression network. Weak correlations were observed between cortisol and alpha-amylase in anxiety and depressive symptoms. Cortisol awekening response (CAR) had a negative correlation with alpha-amylase awakening response (AAR) (−0.54), as like AAR and Faint/lightheaded (−0.57) in anxiety network. Anxiety network structures did not differ between groups (<i>p</i> = 0.18), but the depression network was more connected in controls than in OLP cases (overall strength 69.29 vs. 27.35, <i>p</i> < 0.000).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study reveals the distinct network structures of anxiety and depression symptoms in OLP patients, highlighting a new methodological approach to exploring symptom configurations. When exploring the relationship with cortisol and alpha-amylase, weak relationships were found between them. The findings may prompt further network studies involving biomarkers and their interaction with anxiety and depression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"872-883"},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MiRNAs have essential research value and broad clinical application prospects in oral cancer.
Aims
We provided a comprehensive understanding of trends, current features, and priorities in the field of miRNA and oral cancer research based on bibliometrics.
Materials and Methods
Reference records were obtained from the Web of Science core collection and analyzed using CiteSpace 6.2.4, VOSviewer 1.6.20, and GraphPad Prism 8.
Results
Results showed that between 2008 and 2024, a total of 1149 publications in the database were retrieved to study the role of miRNAs in oral cancer. The annual number of publications showed an increasing trend from year to year, peaking in 2021. Among them, China (470 articles), China Medical University (37 articles), and the journal Oral Oncology demonstrated the highest research productivity in terms of countries (regions), institutions, and journals.
Discussion
Keywords and cited literature indicate that the current research focus is mainly on microenvironmentally- derived miRNAs as potential diagnostic and therapeutic targets for oral cancer. Recent studies have gradually focused on the experimental study of drug delivery systems of miRNAs in treating oral cancer, which may become one of the important research directions in the future.
Conclusions
Thus, by searching the literature in the field of miRNAs and oral cancer from the Web of Science core collection and performing bibliometric analysis, the development of research and research hotspots in the last two decades was mapped out. This will provide valuable references and guidelines for relevant scholars and researchers to explore the direction in future research endeavors.
背景：MiRNAs在口腔癌中具有重要的研究价值和广阔的临床应用前景。目的：我们基于文献计量学对miRNA和口腔癌研究领域的趋势、当前特征和重点进行了全面的了解。材料和方法：从Web of Science核心文集中获取文献记录，使用CiteSpace 6.2.4、VOSviewer 1.6.20和GraphPad Prism 8进行分析。结果：结果显示，2008年至2024年间，共检索数据库中1149篇研究miRNAs在口腔癌中的作用的出版物。年发表数呈逐年增加趋势，在2021年达到顶峰。其中，中国（470篇）、中国医科大学（37篇）和《口腔肿瘤学》杂志在国家（地区）、机构和期刊上的研究生产力最高。讨论：关键词和引用文献表明，目前的研究重点主要是微环境来源的mirna作为口腔癌的潜在诊断和治疗靶点。近年来的研究逐渐集中在mirna药物传递系统治疗口腔癌的实验研究上，这可能成为未来重要的研究方向之一。由此，通过检索Web of Science核心馆藏中miRNAs与口腔癌领域的文献，并进行文献计量分析，勾勒出近二十年的研究发展和研究热点。这将为相关学者和研究人员探索未来的研究方向提供有价值的参考和指导。
{"title":"Bibliometrics-Based Mapping of Research on the Role of miRNAs in Oral Cancer","authors":"Yujing Wang, Rujie Shi, Baisheng Wang, Kun Li","doi":"10.1111/jop.70037","DOIUrl":"10.1111/jop.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>MiRNAs have essential research value and broad clinical application prospects in oral cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>We provided a comprehensive understanding of trends, current features, and priorities in the field of miRNA and oral cancer research based on bibliometrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Reference records were obtained from the Web of Science core collection and analyzed using CiteSpace 6.2.4, VOSviewer 1.6.20, and GraphPad Prism 8.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results showed that between 2008 and 2024, a total of 1149 publications in the database were retrieved to study the role of miRNAs in oral cancer. The annual number of publications showed an increasing trend from year to year, peaking in 2021. Among them, China (470 articles), China Medical University (37 articles), and the journal <i>Oral Oncology</i> demonstrated the highest research productivity in terms of countries (regions), institutions, and journals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Keywords and cited literature indicate that the current research focus is mainly on microenvironmentally- derived miRNAs as potential diagnostic and therapeutic targets for oral cancer. Recent studies have gradually focused on the experimental study of drug delivery systems of miRNAs in treating oral cancer, which may become one of the important research directions in the future.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Thus, by searching the literature in the field of miRNAs and oral cancer from the Web of Science core collection and performing bibliometric analysis, the development of research and research hotspots in the last two decades was mapped out. This will provide valuable references and guidelines for relevant scholars and researchers to explore the direction in future research endeavors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"777-789"},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessia Riente, Alessio Abeltino, Cassandra Serantoni, Michele Maria De Giulio, Giada Bianchetti, Mariaconsiglia Santantonio, Giulio Cesare Passali, Stefano Capezzone, Rosita Esposito, Marco De Spirito, Giuseppe Maulucci
<div> <section> <h3> Background</h3> <p>Trigeminal neuralgia (TN) is a rare and debilitating condition characterized by severe, episodic facial pain, with an incidence of about five individuals per 100 000 annually, predominantly affecting women aged 50–70 years. TN is often difficult to diagnose; leading to underestimation or misdiagnosis and prolonged patient suffering.</p> </section> <section> <h3> Objective</h3> <p>This study aimed to assess masticatory dysfunction in individuals with and without TN using an electromyographic device (“Chewing”) and evaluate its potential to quantify pain-related dysfunction and inform treatment approaches.</p> </section> <section> <h3> Methods</h3> <p>This observational study assessed masticatory dysfunction in TN patients and healthy controls using “Chewing” device. Masticatory behavior was monitored with apple and carrot as test foods, and parameters such as chewing time, number of chews, and chewing force were recorded. Participants were clustered based on masticatory patterns using an unsupervised learning approach.</p> </section> <section> <h3> Results</h3> <p>Two distinct clusters of masticatory behavior emerged from the analysis. Cluster 1, representing 27.5% of TN1 patients, was characterized by prolonged chewing duration, a greater number of chewing cycles, and reduced chewing force compared to Cluster 0. Specifically, during apple mastication, Cluster 1 showed a 24% increase in chewing time (<i>p</i> = 0.02), a twofold increase in the number of chews (<i>p</i> < 0.001), and a 50% reduction in chewing force (<i>p</i> < 0.001). When chewing carrots, the number of chews increased by 57% (<i>p</i> < 0.001), while chewing force decreased by 64% (<i>p</i> < 0.001). Chewing frequency was also significantly higher in Cluster 1 for both food types (<i>p</i> < 0.001). Furthermore, a higher prevalence of TN1 patients was found in Cluster 1 compared to Cluster 0 (χ<sup>2</sup> = 4.53, <i>p</i> = 0.05), suggesting an association between altered masticatory behavior and trigeminal neuralgia. Nonetheless, the presence of some TN1 patients in Cluster 0 indicates that masticatory function may remain intact in certain individuals, possibly due to milder pain symptoms or the development of compensatory coping strategies.</p> </section> <section> <h3> Conclusions</h3> <p>“Chewing” device successfully quantified and differentiated masticatory patterns, providing valuable insights into functional adaptations
背景：三叉神经痛（TN）是一种罕见的衰弱性疾病，其特征是严重的、发作性面部疼痛，每年每10万人中约有5人发病，主要影响50-70岁的女性。TN通常难以诊断；导致低估或误诊，延长患者的痛苦。目的：本研究旨在使用肌电图装置（“咀嚼”）评估有和没有TN的个体的咀嚼功能障碍，并评估其量化疼痛相关功能障碍和告知治疗方法的潜力。方法：本观察性研究使用“咀嚼”装置评估TN患者和健康对照者的咀嚼功能障碍。以苹果、胡萝卜为试验食物监测咀嚼行为，记录咀嚼时间、咀嚼次数、咀嚼力度等参数。使用无监督学习方法根据咀嚼模式对参与者进行聚类。结果：从分析中出现了两个不同的咀嚼行为集群。第1组占TN1患者的27.5%，与第0组相比，其特征是咀嚼时间延长，咀嚼循环次数增加，咀嚼力降低。具体而言，在咀嚼苹果时，集群1咀嚼时间增加24% (p = 0.02)，咀嚼次数增加两倍（p 2 = 4.53, p = 0.05），表明咀嚼行为改变与三叉神经痛之间存在关联。然而，在第0组中出现的一些TN1患者表明，某些个体的咀嚼功能可能保持完整，这可能是由于较轻的疼痛症状或代偿性应对策略的发展。结论：“咀嚼”装置成功地量化和区分了咀嚼模式，为功能适应提供了有价值的见解。根据咀嚼行为对TN患者进行亚组可以指导个性化治疗策略，改善患者预后。
{"title":"Using Quantitative Masticatory Dysfunction to Inform Pain Management in Trigeminal Neuralgia Through Electromyographic Monitoring","authors":"Alessia Riente, Alessio Abeltino, Cassandra Serantoni, Michele Maria De Giulio, Giada Bianchetti, Mariaconsiglia Santantonio, Giulio Cesare Passali, Stefano Capezzone, Rosita Esposito, Marco De Spirito, Giuseppe Maulucci","doi":"10.1111/jop.70035","DOIUrl":"10.1111/jop.70035","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Trigeminal neuralgia (TN) is a rare and debilitating condition characterized by severe, episodic facial pain, with an incidence of about five individuals per 100 000 annually, predominantly affecting women aged 50–70 years. TN is often difficult to diagnose; leading to underestimation or misdiagnosis and prolonged patient suffering.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to assess masticatory dysfunction in individuals with and without TN using an electromyographic device (“Chewing”) and evaluate its potential to quantify pain-related dysfunction and inform treatment approaches.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This observational study assessed masticatory dysfunction in TN patients and healthy controls using “Chewing” device. Masticatory behavior was monitored with apple and carrot as test foods, and parameters such as chewing time, number of chews, and chewing force were recorded. Participants were clustered based on masticatory patterns using an unsupervised learning approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two distinct clusters of masticatory behavior emerged from the analysis. Cluster 1, representing 27.5% of TN1 patients, was characterized by prolonged chewing duration, a greater number of chewing cycles, and reduced chewing force compared to Cluster 0. Specifically, during apple mastication, Cluster 1 showed a 24% increase in chewing time (<i>p</i> = 0.02), a twofold increase in the number of chews (<i>p</i> < 0.001), and a 50% reduction in chewing force (<i>p</i> < 0.001). When chewing carrots, the number of chews increased by 57% (<i>p</i> < 0.001), while chewing force decreased by 64% (<i>p</i> < 0.001). Chewing frequency was also significantly higher in Cluster 1 for both food types (<i>p</i> < 0.001). Furthermore, a higher prevalence of TN1 patients was found in Cluster 1 compared to Cluster 0 (χ<sup>2</sup> = 4.53, <i>p</i> = 0.05), suggesting an association between altered masticatory behavior and trigeminal neuralgia. Nonetheless, the presence of some TN1 patients in Cluster 0 indicates that masticatory function may remain intact in certain individuals, possibly due to milder pain symptoms or the development of compensatory coping strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>“Chewing” device successfully quantified and differentiated masticatory patterns, providing valuable insights into functional adaptations","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"863-871"},"PeriodicalIF":2.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maribasappa Karched, Asma Hanif, Radhika G. Bhardwaj, Mai E. Khalaf, Muawia A. Qudeimat
Objective
To investigate the interaction between fluconazole-resistant (Flu-R) and -susceptible dose-dependent (Flu-SDD) isolates of Candida albicans and Candida glabrata with oral streptococci, exploring autoaggregation, coaggregation, and the impact of streptococcal biofilm-secreted components on Candida biofilms.
Methods
Autoaggregation and coaggregation of Candida Flu-R and Flu-SDD isolates with streptococci ( S. mutans , S. gordonii , and S. sanguinis ) were assessed using an optical density assay. The inhibitory effects of streptococcal biofilm-secreted components on Candida biofilms were examined, quantifying biofilm inhibition by crystal violet staining and assessing viability through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Statistical analysis of the data was done by one-way ANOVA, considering a p-value of < 0.05 as significant.
Results
Flu-R C. albicans exhibited higher autoaggregation (71%) than Flu-SDD (62%), both surpassing Streptococcus spp. (32%–49%). Flu-R and Flu-SDD C. glabrata had less autoaggregation ability than C. albicans (p < 0.05). Coaggregation increased steadily, with Flu-SDD C. albicans exhibiting the highest coaggregation with S. mutans (69% ± 8% at 2 h). Flu-R strains showed significant coaggregation differences with streptococcal species (p-values 0.05–< 0.001). Biofilm inhibition was significant in Candida Flu-R and Flu-SDD isolates treated with streptococcal biofilm supernatants. Supernatants of all three streptococcal species decreased Flu-R C. albicans viability (1.15–2.15-fold).
Conclusions
Fluconazole susceptibility/resistance significantly influences aggregation and biofilm formation with oral streptococci. Streptococcal biofilm supernatants hinder Candida strains' growth and viability, suggesting implications for colonization, biofilm formation, and oral infections.
{"title":"Influence of Fluconazole Resistance and Susceptibility on Candida–Streptococci Aggregation Dynamics","authors":"Maribasappa Karched, Asma Hanif, Radhika G. Bhardwaj, Mai E. Khalaf, Muawia A. Qudeimat","doi":"10.1111/jop.70034","DOIUrl":"10.1111/jop.70034","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the interaction between fluconazole-resistant (Flu-R) and -susceptible dose-dependent (Flu-SDD) isolates of \u0000 <i>Candida albicans</i>\u0000 and <i>Candida glabrata</i> with oral <i>streptococci</i>, exploring autoaggregation, coaggregation, and the impact of streptococcal biofilm-secreted components on <i>Candida</i> biofilms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Autoaggregation and coaggregation of <i>Candida</i> Flu-R and Flu-SDD isolates with <i>streptococci</i> (\u0000 <i>S. mutans</i>\u0000 , \u0000 <i>S. gordonii</i>\u0000 , and \u0000 <i>S. sanguinis</i>\u0000 ) were assessed using an optical density assay. The inhibitory effects of streptococcal biofilm-secreted components on <i>Candida</i> biofilms were examined, quantifying biofilm inhibition by crystal violet staining and assessing viability through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Statistical analysis of the data was done by one-way ANOVA, considering a <i>p</i>-value of < 0.05 as significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Flu-R \u0000 <i>C. albicans</i>\u0000 exhibited higher autoaggregation (71%) than Flu-SDD (62%), both surpassing <i>Streptococcus</i> spp. (32%–49%). Flu-R and Flu-SDD \u0000 <i>C. glabrata</i>\u0000 had less autoaggregation ability than \u0000 <i>C. albicans</i>\u0000 (<i>p</i> < 0.05). Coaggregation increased steadily, with Flu-SDD \u0000 <i>C. albicans</i>\u0000 exhibiting the highest coaggregation with \u0000 <i>S. mutans</i>\u0000 (69% ± 8% at 2 h). Flu-R strains showed significant coaggregation differences with streptococcal species (<i>p</i>-values 0.05–< 0.001). Biofilm inhibition was significant in <i>Candida</i> Flu-R and Flu-SDD isolates treated with streptococcal biofilm supernatants. Supernatants of all three streptococcal species decreased Flu-R \u0000 <i>C. albicans</i>\u0000 viability (1.15–2.15-fold).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Fluconazole susceptibility/resistance significantly influences aggregation and biofilm formation with oral <i>streptococci</i>. Streptococcal biofilm supernatants hinder <i>Candida</i> strains' growth and viability, suggesting implications for colonization, biofilm formation, and oral infections.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"853-862"},"PeriodicalIF":2.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Variants in the dentin sialophosphoprotein (DSPP) gene are known to cause hereditary dentin disorders, including dentinogenesis imperfecta (DGI), which is characterized by abnormal dentin development and structure. However, the full spectrum of clinical manifestations and the impact of specific variants remain to be fully elucidated.
Methods
Oral and radiological examinations were conducted on eight patients from two families. Physical characterization of deciduous DGI teeth and matched controls was performed. Exome and Sanger sequencing were employed for variant detection.
Results
All patients exhibited opalescent teeth with bulbous crowns and pulpal obliteration. A copper-beaten skull appearance was detected in one proband, indicating craniosynostosis and necessitating immediate medical intervention. Ultrastructural analyses revealed a dark and red-yellow tone in deciduous DGI teeth. DGI dentin exhibited decreased mineral density, hardness, and elastic modulus, along with disruption of dentinal tubules, the dentinoenamel junction, and mineral contents. Two novel heterozygous frameshift variants in DSPP, c.2317del and c.3555del, were identified in families A and B, respectively, both located in exon 5, expected to alter the repeating sequence pattern of the dentin phosphoprotein (DPP) protein.
Conclusion
This study identifies two novel frameshift variants in the DPP region associated with compromised dentin properties, composition, and ultrastructure. These findings expand the genotype and phenotype spectra of DSPP-DGI, highlighting the crucial role of dentists not only in addressing dental diseases but also in contributing to broader medical interventions.
{"title":"Unveiling Novel DSPP Variants and Dental Phenotypes in Dentinogenesis Imperfecta","authors":"Angkana Boonyakanog, Thanakorn Theerapanon, Tanit Arunratanothai, Somchai Yodsanga, Nond Rojvachiranonda, Lakshman Samaranayake, Wuttichart Kamolvisit, Vorasuk Shotelersuk, Thantrira Porntaveetus","doi":"10.1111/jop.70030","DOIUrl":"10.1111/jop.70030","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Variants in the dentin sialophosphoprotein (<i>DSPP</i>) gene are known to cause hereditary dentin disorders, including dentinogenesis imperfecta (DGI), which is characterized by abnormal dentin development and structure. However, the full spectrum of clinical manifestations and the impact of specific variants remain to be fully elucidated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Oral and radiological examinations were conducted on eight patients from two families. Physical characterization of deciduous DGI teeth and matched controls was performed. Exome and Sanger sequencing were employed for variant detection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All patients exhibited opalescent teeth with bulbous crowns and pulpal obliteration. A copper-beaten skull appearance was detected in one proband, indicating craniosynostosis and necessitating immediate medical intervention. Ultrastructural analyses revealed a dark and red-yellow tone in deciduous DGI teeth. DGI dentin exhibited decreased mineral density, hardness, and elastic modulus, along with disruption of dentinal tubules, the dentinoenamel junction, and mineral contents. Two novel heterozygous frameshift variants in <i>DSPP</i>, c.2317del and c.3555del, were identified in families A and B, respectively, both located in exon 5, expected to alter the repeating sequence pattern of the dentin phosphoprotein (DPP) protein.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study identifies two novel frameshift variants in the DPP region associated with compromised dentin properties, composition, and ultrastructure. These findings expand the genotype and phenotype spectra of <i>DSPP</i>-DGI, highlighting the crucial role of dentists not only in addressing dental diseases but also in contributing to broader medical interventions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"823-834"},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tackling (Oral) Health Disinformation: Not as Easy as It Seems","authors":"Nicola Cirillo","doi":"10.1111/jop.70033","DOIUrl":"10.1111/jop.70033","url":null,"abstract":"","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 8","pages":"609-612"},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cintia Eliza Marques, Everton Freitas de Morais, Bruno Cesar da Costa, Fábio Haach Téo, Ana Lúcia Carrinho Ayroza Rangel, Ricardo D. Coletta, Lívia Maris Ribeiro Paranaiba Dias
Background
Oral squamous cell carcinoma (OSCC) remains a challenging malignancy with poor 5-year survival rates due to diagnosis at an advanced stage and a high likelihood of recurrence and metastasis. These aggressive traits may be influenced by cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT).
Methods
This study investigated the prognostic significance of the CSC marker CD44 and EMT-related proteins (Snail1, Snail2, E-cadherin, N-cadherin) in 132 OSCCs using immunohistochemistry. The comprehensive survival analysis included univariate and multivariate (stepwise method) Cox regression for disease-specific survival (DSS) and disease-free survival (DFS), Kaplan–Meier curves based on log-rank testing, and receiver operating characteristic (ROC) analysis to assess the predictive accuracy of the markers.
Results
High CD44 expression independently predicted worse DSS (HR = 2.74, 95% CI 1.44–5.23, p = 0.003) and DFS (HR = 2.22, 95% CI 1.16–4.23, p = 0.01), and Snail1 was significantly associated with poor DSS (HR = 2.62, 95% CI 1.37–5.03, p = 0.004). The combined expression of CD44 and Snail1 improved the discrimination of worse outcomes compared to markers individually. The presence of lymphovascular invasion (HR = 8.68, 95% CI 3.81–19.75, p < 0.0001) and a positive surgical margin (< 5 mm; HR = 4.45, 95% CI 1.99–9.96, p = 0.0003) were also independently associated with DSS.
Conclusions
The results of this study highlight the prognostic significance of CD44 and Snail1 in OSCC, emphasizing their potential interplay in tumor aggressiveness.
背景：口腔鳞状细胞癌（OSCC）仍然是一种具有挑战性的恶性肿瘤，由于诊断为晚期，复发和转移的可能性高，5年生存率低。这些侵袭性特征可能受到癌症干细胞（CSC）和上皮-间质转化（EMT）的影响。方法：应用免疫组化方法研究132例OSCCs中CSC标志物CD44及emt相关蛋白（Snail1、Snail2、E-cadherin、N-cadherin）的预后意义。综合生存分析包括单因素和多因素（逐步法）疾病特异性生存（DSS）和无病生存（DFS）的Cox回归，基于log-rank检验的Kaplan-Meier曲线，以及评估标志物预测准确性的受试者工作特征（ROC）分析。结果：CD44高表达独立预测较差的DSS （HR = 2.74, 95% CI 1.44-5.23, p = 0.003）和DFS (HR = 2.22, 95% CI 1.16-4.23, p = 0.01)， Snail1与较差的DSS相关（HR = 2.62, 95% CI 1.37-5.03, p = 0.004）。与单独标记物相比，CD44和Snail1的联合表达提高了对不良结果的区分。淋巴血管浸润的存在（HR = 8.68, 95% CI 3.81-19.75, p）结论：本研究结果强调了CD44和Snail1在OSCC中的预后意义，强调了它们在肿瘤侵袭性中的潜在相互作用。
{"title":"CD44 and Snail1 Expression Predicts Poor Prognosis of Oral Squamous Cell Carcinoma","authors":"Cintia Eliza Marques, Everton Freitas de Morais, Bruno Cesar da Costa, Fábio Haach Téo, Ana Lúcia Carrinho Ayroza Rangel, Ricardo D. Coletta, Lívia Maris Ribeiro Paranaiba Dias","doi":"10.1111/jop.70032","DOIUrl":"10.1111/jop.70032","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral squamous cell carcinoma (OSCC) remains a challenging malignancy with poor 5-year survival rates due to diagnosis at an advanced stage and a high likelihood of recurrence and metastasis. These aggressive traits may be influenced by cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study investigated the prognostic significance of the CSC marker CD44 and EMT-related proteins (Snail1, Snail2, E-cadherin, N-cadherin) in 132 OSCCs using immunohistochemistry. The comprehensive survival analysis included univariate and multivariate (stepwise method) Cox regression for disease-specific survival (DSS) and disease-free survival (DFS), Kaplan–Meier curves based on log-rank testing, and receiver operating characteristic (ROC) analysis to assess the predictive accuracy of the markers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>High CD44 expression independently predicted worse DSS (HR = 2.74, 95% CI 1.44–5.23, <i>p</i> = 0.003) and DFS (HR = 2.22, 95% CI 1.16–4.23, <i>p</i> = 0.01), and Snail1 was significantly associated with poor DSS (HR = 2.62, 95% CI 1.37–5.03, <i>p</i> = 0.004). The combined expression of CD44 and Snail1 improved the discrimination of worse outcomes compared to markers individually. The presence of lymphovascular invasion (HR = 8.68, 95% CI 3.81–19.75, <i>p</i> < 0.0001) and a positive surgical margin (< 5 mm; HR = 4.45, 95% CI 1.99–9.96, <i>p</i> = 0.0003) were also independently associated with DSS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results of this study highlight the prognostic significance of CD44 and Snail1 in OSCC, emphasizing their potential interplay in tumor aggressiveness.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"835-845"},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammed Abdullah Çege, Öykü Öztürk Gündoğdu, Zühre Kaya, Zühre Akarslan, Dilek Aynur Çankal
Objective
The aim of this study was to assess mandibular trabecular bone health in patients with inherited bleeding disorders using fractal analysis (FA) on digital panoramic radiographs (DPR).
Methods
Thirty-five patients with hereditary bleeding disorders (hemophilia A or B, and von Willebrand disease (VWD)) and 35 healthy controls were included. Data were collected on factor levels, inhibitor status, bleeding history, factor replacement therapy, vitamin D use, and calcium supplementation. Using ImageJ software, FA was performed from the determined regions in the mandible via DPR: ROI-1 (condylar region), ROI-2 (mandibular angle) and ROI-3 (molar region). Each region was independently evaluated by a radiologist and a maxillofacial surgeon trained in FA.
Results
Of the patients, 23 (65%) had severe hemophilia, 3 (8%) had type III VWD, 5 (15%) had moderate hemophilia, and 4 (12%) had type I VWD. Interobserver agreement for FA measurements in the condyle, angle, and molar areas was almost perfect (Kw = 0.992–0.993). In these three regions, no statistically significant differences in mean FA values were found between patients and controls, regardless of age or gender (p > 0.05). However, four high-risk patients—one with severe hemophilia B with inhibitors, two with type III VWD, and one with severe hemophilia A on an on-demand regimen—displayed significantly lower mean FA values in the condylar region compared to controls (p < 0.05). These findings suggest that while most patients with inherited bleeding disorders may not show marked alterations in mandibular trabecular bone structure, some high-risk individuals could have compromised bone health detectable via FA.
Conclusion
This preliminary study indicates that FA may be a valuable tool for identifying at-risk patients with inherited bleeding disorders. Larger studies are needed to confirm these preliminary findings.
{"title":"Assessment of Mandibular Trabecular Bone by Fractal Analysis on Digital Panoramic Radiograph in Patients with Inherited Bleeding Disorder","authors":"Muhammed Abdullah Çege, Öykü Öztürk Gündoğdu, Zühre Kaya, Zühre Akarslan, Dilek Aynur Çankal","doi":"10.1111/jop.70036","DOIUrl":"10.1111/jop.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to assess mandibular trabecular bone health in patients with inherited bleeding disorders using fractal analysis (FA) on digital panoramic radiographs (DPR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-five patients with hereditary bleeding disorders (hemophilia A or B, and von Willebrand disease (VWD)) and 35 healthy controls were included. Data were collected on factor levels, inhibitor status, bleeding history, factor replacement therapy, vitamin D use, and calcium supplementation. Using ImageJ software, FA was performed from the determined regions in the mandible via DPR: ROI-1 (condylar region), ROI-2 (mandibular angle) and ROI-3 (molar region). Each region was independently evaluated by a radiologist and a maxillofacial surgeon trained in FA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the patients, 23 (65%) had severe hemophilia, 3 (8%) had type III VWD, 5 (15%) had moderate hemophilia, and 4 (12%) had type I VWD. Interobserver agreement for FA measurements in the condyle, angle, and molar areas was almost perfect (<i>Kw</i> = 0.992–0.993). In these three regions, no statistically significant differences in mean FA values were found between patients and controls, regardless of age or gender (<i>p</i> > 0.05). However, four high-risk patients—one with severe hemophilia B with inhibitors, two with type III VWD, and one with severe hemophilia A on an on-demand regimen—displayed significantly lower mean FA values in the condylar region compared to controls (<i>p</i> < 0.05). These findings suggest that while most patients with inherited bleeding disorders may not show marked alterations in mandibular trabecular bone structure, some high-risk individuals could have compromised bone health detectable via FA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This preliminary study indicates that FA may be a valuable tool for identifying at-risk patients with inherited bleeding disorders. Larger studies are needed to confirm these preliminary findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"846-852"},"PeriodicalIF":2.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabela de Sousa Slivar, Bruno de Andrade Zanesco, Manoela Domingues Martins, Leandro Luongo Matos, Fábio Daumas Nunes, Lauren Frenzel Schuch, Vivian Petersen Wagner
Background
Most studies suggest that NOTCH1 alterations are associated with prognosis in adenoid cystic carcinoma (ACC), but findings remain fragmented. We conducted an integrative analysis to evaluate the prognostic value of NOTCH1-related biomarkers in ACC.
Methods
A comprehensive search was conducted across multiple databases. Inclusion criteria comprised studies examining NOTCH1-related features at ACC diagnosis and their relation with survival outcomes. Meta-analysis was performed on studies sharing similar methodology.
Results
Twelve studies met the eligibility criteria. NOTCH1 mutational status, Notch1 immunoexpression, and NICD1 immunoexpression were associated either with overall, disease-free or progression-free survival. Methodological disparities hindered integration of results. Meta-analyses of HRs were conducted with 2 studies for each index factor, revealing a 2.31-fold increased risk of death for primary ACC cases with NOTCH1 mutations, a 2.6-fold increased risk of death for those exhibiting positive NICD1 expression and a 1.91-fold heightened risk of disease recurrence for cases with high Notch1 expression.
Conclusion
This comprehensive review underscores the prognostic relevance of NOTCH1 in ACC, indicating its potential as a valuable risk stratification tool.
{"title":"Deciphering NOTCH1 as a Biomarker in Adenoid Cystic Carcinoma: Insights From a Systematic Review With Meta-Analysis","authors":"Isabela de Sousa Slivar, Bruno de Andrade Zanesco, Manoela Domingues Martins, Leandro Luongo Matos, Fábio Daumas Nunes, Lauren Frenzel Schuch, Vivian Petersen Wagner","doi":"10.1111/jop.70028","DOIUrl":"10.1111/jop.70028","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Most studies suggest that NOTCH1 alterations are associated with prognosis in adenoid cystic carcinoma (ACC), but findings remain fragmented. We conducted an integrative analysis to evaluate the prognostic value of NOTCH1-related biomarkers in ACC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive search was conducted across multiple databases. Inclusion criteria comprised studies examining NOTCH1-related features at ACC diagnosis and their relation with survival outcomes. Meta-analysis was performed on studies sharing similar methodology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twelve studies met the eligibility criteria. NOTCH1 mutational status, Notch1 immunoexpression, and NICD1 immunoexpression were associated either with overall, disease-free or progression-free survival. Methodological disparities hindered integration of results. Meta-analyses of HRs were conducted with 2 studies for each index factor, revealing a 2.31-fold increased risk of death for primary ACC cases with NOTCH1 mutations, a 2.6-fold increased risk of death for those exhibiting positive NICD1 expression and a 1.91-fold heightened risk of disease recurrence for cases with high Notch1 expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This comprehensive review underscores the prognostic relevance of NOTCH1 in ACC, indicating its potential as a valuable risk stratification tool.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 8","pages":"647-657"},"PeriodicalIF":2.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Florian Dudde, Dominik Fildebrandt, Paul Kock, Karin Petz, Ralf Smeets, Martin Gosau, Michael Amling, Thomas Beikler, Florian Barvencik
Aim
Vitamin D deficiency is common in hypophosphatasia (HPP) patients. However, its impact on oral health is unclear. Therefore, the purpose of this study was to investigate the relationship between Vitamin D levels and oral health in adults with hypophosphatasia.
Materials and Methods
In this retrospective study, oral health and bone metabolism in HPP patients were examined. The Decayed/Missing/Filled Teeth (DMFT) index, clinical attachment level (CAL), probing pocket depth (PPD), and periodontal screening index (PSI) were among the metrics used to evaluate oral health.
Results
The average age of the 48 HPP patients in the study was 42.21 (±15.78) years. A mean Vitamin D level of 29 μg/L was used to divide the participants into two groups. Compared to patients with Vitamin D levels above 29 μg/L, those with levels below this threshold showed noticeably worse oral health, as evidenced by higher PSI, PPD, decayed tooth count, and periodontitis severity index.
Conclusion
The results imply that adults with HPP who have low Vitamin D levels have worse oral health. To potentially improve oral health, it is crucial to diagnose and treat Vitamin D deficiency in HPP patients, as it is a known risk factor for periodontitis in the general population.
{"title":"Influence of Vitamin D Level on Oral Health Status in Adult Hypophosphatasia","authors":"Florian Dudde, Dominik Fildebrandt, Paul Kock, Karin Petz, Ralf Smeets, Martin Gosau, Michael Amling, Thomas Beikler, Florian Barvencik","doi":"10.1111/jop.70039","DOIUrl":"10.1111/jop.70039","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Vitamin D deficiency is common in hypophosphatasia (HPP) patients. However, its impact on oral health is unclear. Therefore, the purpose of this study was to investigate the relationship between Vitamin D levels and oral health in adults with hypophosphatasia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this retrospective study, oral health and bone metabolism in HPP patients were examined. The Decayed/Missing/Filled Teeth (DMFT) index, clinical attachment level (CAL), probing pocket depth (PPD), and periodontal screening index (PSI) were among the metrics used to evaluate oral health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The average age of the 48 HPP patients in the study was 42.21 (±15.78) years. A mean Vitamin D level of 29 μg/L was used to divide the participants into two groups. Compared to patients with Vitamin D levels above 29 μg/L, those with levels below this threshold showed noticeably worse oral health, as evidenced by higher PSI, PPD, decayed tooth count, and periodontitis severity index.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results imply that adults with HPP who have low Vitamin D levels have worse oral health. To potentially improve oral health, it is crucial to diagnose and treat Vitamin D deficiency in HPP patients, as it is a known risk factor for periodontitis in the general population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"798-806"},"PeriodicalIF":2.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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