Journal of Oral Pathology & Medicine最新文献_第6页

Tumor immune microenvironment in odontogenic carcinomas: Evaluation of the therapeutic potential of immune checkpoint blockade 牙源性癌的肿瘤免疫微环境：评估免疫检查点阻断的治疗潜力。

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-03-06 DOI: 10.1111/jop.13525

Kyu-Young Oh, Seong-Doo Hong, Hye-Jung Yoon

Background

Despite recent advances in the use of immune checkpoint blockade (ICB) across various cancer types, its efficacy in odontogenic carcinomas remains unexplored. This study aims to investigate PD-L1 expression and the tumor immune microenvironment (TIME) in odontogenic carcinomas to determine the therapeutic potential of ICB and the significance of immune markers.

Methods

The expressions of PD-L1 and T cell markers (CD3, CD8, and FOXP3) were visualized by immunohistochemistry in 21 tissue samples of odontogenic carcinomas. Tumoral PD-L1 expression and the density and spatial distribution of T cell subsets were evaluated, from which TIME was determined. The associations of the variables with clinicopathological and prognostic factors were statistically analyzed.

Results

PD-L1 was positively expressed in 52.4% (11/21) of the cases studied. Among tumor types, ameloblastic carcinoma showed significantly higher PD-L1 expression (p = 0.016). TIME based on the intratumoral and stromal T cell distribution was immune-inflamed in 61.9% (13/21) and immune-excluded in 38.1% (8/21), with no immune-desert cases. PD-L1 expression was associated with the densities of all intratumoral T cell subsets (p = 0.03 for CD3, p = 0.03 for CD8, and p = 0.008 for FOXP3) but not with those of stromal T cells. High PD-L1 expression was associated with larger tumor size (p = 0.021), while the intratumoral CD8/CD3 ratio was inversely correlated with tumor size (p = 0.048).

Conclusion

These findings indicate the involvement of adaptive immune resistance in a subset of odontogenic carcinomas and support the therapeutic potential of ICB in patients with these rare malignancies.

背景：尽管免疫检查点阻断疗法（ICB）在各种癌症类型中的应用取得了最新进展，但其在牙源性癌中的疗效仍有待探索。本研究旨在调查牙源性癌中PD-L1的表达和肿瘤免疫微环境（TIME），以确定ICB的治疗潜力和免疫标记物的重要性：方法：采用免疫组化方法观察21个牙源性癌组织样本中PD-L1和T细胞标记物（CD3、CD8和FOXP3）的表达。评估了肿瘤 PD-L1 的表达以及 T 细胞亚群的密度和空间分布，并由此确定了 TIME。统计分析了这些变量与临床病理和预后因素的关系：结果：52.4%（11/21）的研究病例中 PD-L1 呈阳性表达。在肿瘤类型中，骨髓癌的PD-L1表达量明显更高（p = 0.016）。根据瘤内和基质 T 细胞分布，61.9%（13/21）的 TIME 为免疫炎症型，38.1%（8/21）为免疫排斥型，无免疫惰性病例。PD-L1 表达与所有瘤内 T 细胞亚群的密度相关（CD3 的 p = 0.03，CD8 的 p = 0.03，FOXP3 的 p = 0.008），但与基质 T 细胞的密度无关。PD-L1的高表达与肿瘤大小有关（p = 0.021），而瘤内CD8/CD3比值与肿瘤大小成反比（p = 0.048）：这些研究结果表明，适应性免疫抵抗参与了一部分牙源性癌的治疗，并支持 ICB 对这类罕见恶性肿瘤患者的治疗潜力。

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引用次数: 0

Salivary and serum biomarkers to evaluate psychological disorders in burning mouth syndrome: A systematic review and meta-analysis 评估灼口综合征心理障碍的唾液和血清生物标记物：系统回顾和荟萃分析。

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-03-04 DOI: 10.1111/jop.13526

Mei He, Wuda Huoshen, Xueqing Li, Chen Sun

Background

Burning mouth syndrome is a chronic pain syndrome mainly characterized by an intensive burning sensation of tongue. Previous studies have suggested that saliva/serum biomarkers in burning mouth syndrome might be associated with psychological disorders. The aim of systematic review was to observe whether the biomarkers in serum/saliva could be an alternative method to evaluate the psychological disorders in patients with burning mouth syndrome.

Materials and Methods

The PubMed, Embase, and Cochrane Library databases were searched for papers published up to March 15, 2023. Risk of bias was measured by using the Newcastle-Ottawa Scale. RevMan was used for meta-analysis.

Results

A total of 467 articles were screened, which of 12 studies were included. These studies collected 43 different biomarkers in saliva and 35 in serum. Of these biomarkers, only three (cortisol, α-amylase, and IL-6) were analyzed in two or more studies. Only salivary cortisol levels were significantly higher in the patient group compared to the controls (Mean Difference = 1.39; 95% CI [0.80–1.97]; p < 0.001). Moreover, cortisol might be relevant to psychological scores, especially anxiety.

Conclusion

Different papers have investigated salivary and serum biomarkers in burning mouth syndrome patients with controversial results. This meta-analysis showed that cortisol levels in saliva may be a potential biomarker to assess the psychological disorders in burning mouth syndrome patients.

背景介绍灼口综合征是一种慢性疼痛综合征，主要特征是舌头有强烈的灼烧感。以往的研究表明，烧灼感口腔综合征的唾液/血清生物标志物可能与心理障碍有关。系统综述的目的是观察血清/唾液中的生物标志物是否可以作为评估灼口综合征患者心理障碍的替代方法：在PubMed、Embase和Cochrane图书馆数据库中检索了截至2023年3月15日发表的论文。使用纽卡斯尔-渥太华量表测量偏倚风险。RevMan用于荟萃分析：共筛选出 467 篇文章，其中 12 项研究被纳入。这些研究在唾液中收集了 43 种不同的生物标记物，在血清中收集了 35 种不同的生物标记物。在这些生物标志物中，只有三种（皮质醇、α-淀粉酶和 IL-6）在两项或两项以上的研究中进行了分析。只有患者组的唾液皮质醇水平明显高于对照组（平均差 = 1.39；95% CI [0.80-1.97]；P 结论：患者组的唾液皮质醇水平明显高于对照组（平均差 = 1.39；95% CI [0.80-1.97]）：不同的论文对烧灼伤口腔综合征患者的唾液和血清生物标志物进行了研究，但结果存在争议。这项荟萃分析表明，唾液中的皮质醇水平可能是评估灼口综合征患者心理障碍的潜在生物标志物。

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引用次数: 0

Corrigendum: The expression of MACC1 and its role in the proliferation and apoptosis of salivary adenoid cystic carcinoma 更正 "MACC1的表达及其在唾液腺样囊性癌增殖和凋亡中的作用"。

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-02-29 DOI: 10.1111/jop.13522

Haifeng L, Liao X, Shen Z, Xiangfeng G, Haigang L, Huang Z. The expression of MACC1 and its role in the proliferation and apoptosis of salivary adenoid cystic carcinoma. J Oral Pathol Med. 2015; 44: 810-817.

The revision of our manuscript is prompted by the concerns raised by Jennifer Byrne and colleagues regarding the nucleotide sequence reagents used in our paper titled “The expression of MACC1 and its role in the proliferation and apoptosis of salivary adenoid cystic carcinoma.”

Upon thorough examination of the nucleotide sequence (5’-AAGAUUGGACUUGUACACUGCTT-3′) of the siRNA, we observed that the siRNA perfectly matches the mRNA of MACC1 after removing the overhanging TT sequence. It is worth noting that the overhanging TT, which does not correspond to the target sequence, is commonly incorporated in siRNA design to enhance thermodynamic stability and RNA interference activity (PMID: 25211666; PMID: 30660935). We speculate that the discrepancy in the sequences presented in the preprint by Jennifer Byrne and colleagues may be due to their algorithm not deleting the base sequence of “TT.”

Furthermore, the small interfering RNA (siRNA) of MACC1 used in our study was procured from GenePharma (Shanghai, China). The siRNA duplexes were synthesized and purified by GenePharma (Shanghai, China). Despite approximately 9 years having passed since the study, we have located the original purchase order. The nucleotide sequence of the siRNA for MACC1 is accurate. However, we identified an error in our manuscript where the antisense of the siRNA for MACC1 was mistakenly inverted. The correct antisense of the siRNA for MACC1 is as follows: 3’-TTUUCUAACCUGAACAUGUGACG-5′ or 5’-GCAGUGUACAAGUCCAAUCUUTT-3′.

We apologize for this error.

L Haifeng L, Liao X, Shen Z, Xiangfeng G, Haigang L, Huang Z. MACC1的表达及其在唾液腺样囊性癌增殖和凋亡中的作用。J Oral Pathol Med.2015; 44: 810-817.由于Jennifer Byrne及其同事对我们题为《MACC1的表达及其在唾液腺样囊性癌增殖和凋亡中的作用》的论文中使用的核苷酸序列试剂提出了疑虑，我们对稿件进行了修订。"在对 siRNA 的核苷酸序列（5'-AAGAUUGGACUUGUACUGCTT-3′）进行深入研究后，我们发现 siRNA 在去除悬空的 TT 序列后与 MACC1 的 mRNA 完全吻合。值得注意的是，在 siRNA 设计中通常会加入与靶序列不一致的悬空 TT 序列，以提高热力学稳定性和 RNA 干扰活性（PMID: 25211666; PMID: 30660935）。我们推测，Jennifer Byrne 及其同事在预印本中提出的序列差异可能是由于他们的算法没有删除 "TT "的碱基序列。此外，我们研究中使用的 MACC1 小干扰 RNA（siRNA）购自 GenePharma（中国上海）。siRNA 双链由基因工程有限公司（中国上海）合成和纯化。尽管研究已经过去了大约 9 年，但我们仍然找到了原始订购单。MACC1 siRNA 的核苷酸序列是准确的。然而，我们在手稿中发现了一个错误，即 MACC1 siRNA 的反义被错误地颠倒了。MACC1 siRNA 的正确反义如下：3'-TTUUCUAACCUGAACAUGUGACG-5′ 或 5'-GCAGUGUACAAGUCCAAUCUUTT-3′.

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引用次数: 0

Depth of invasion of oral squamous cell carcinoma in Nos2-knockout mice correlated to alterations in systemic inflammatory markers following 4NQO treatment Nos2基因敲除小鼠口腔鳞状细胞癌的侵袭深度与4NQO治疗后全身炎症标志物的变化相关。

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-02-28 DOI: 10.1111/jop.13523

Débora de Oliveira Santos, Anaíra Ribeiro Guedes Fonseca Costa, Pedro Victor Silva Duarte, Tássio Edno Atanásio Pitorro, Lúbia Cristina Fonseca, Sérgio Vitorino Cardoso, Paulo Rogério de Faria, Adriano Mota Loyola

Background

Peripheral blood analysis is a non-invasive and low-cost technique of prognostic value for several diseases, including oral cancer. Considering the role of inducible nitric oxide synthase in tumor-associated inflammation, this study purposed to evaluate the influence of this enzyme on peripheral blood parameters and systemic inflammatory biomarkers during murine oral carcinogenesis.

Methods

A 50 μg/mL solution of 4-nitroquinoleine-N-oxide was provided to 15 C57BL/6J (Nos2^+/+) and 16 B6.129P2-Nos2^tm1Lau/J (Nos2^−/−) for 16 weeks. Animals were followed for 8 weeks after treatment. Blood samples and tongues were collected for hematological and histopathological analyses. Red blood cells, white blood cells, and platelet cell parameters were analyzed. The neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and the systemic immune-inflammation index were also calculated. The depth of invasion of all carcinomas was measured.

Results

Differences were found in several blood parameters. The depth of invasion in Nos2^−/− was lower than in Nos2^+/+ (p = 0.009), and strong correlations were found between depth of invasion and neutrophil count (ρ = −0.68, p = 0.017), lymphocyte count (ρ = 0.72, p = 0.011), neutrophil-to-lymphocyte ratio (ρ = −0.65, p = 0.025), platelet-to-lymphocyte ratio (ρ = −0.73, p = 0.013), and systemic immune-inflammation index (ρ = −0.67, p = 0.037) in Nos2^−/− mice.

Conclusion

Inducible nitric oxide synthase seems to have an important role in OSCC invasion and progression, which might be associated to alterations in immune-inflammatory cell dynamics evidenced by peripheral blood and systemic inflammatory biomarkers.

背景：外周血分析是一种无创、低成本的技术，对包括口腔癌在内的多种疾病具有预后价值。考虑到诱导型一氧化氮合酶在肿瘤相关炎症中的作用，本研究旨在评估在小鼠口腔癌发生过程中该酶对外周血参数和全身炎症生物标志物的影响：给 15 只 C57BL/6J （Nos2+/+）和 16 只 B6.129P2-Nos2tm1Lau /J （Nos2-/-）提供 50 μg/mL 的 4-硝基喹啉-N-氧化物溶液，为期 16 周。治疗后对动物进行了 8 周的随访。采集血样和舌头进行血液学和组织病理学分析。分析了红细胞、白细胞和血小板的参数。还计算了中性粒细胞与淋巴细胞比率、血小板与淋巴细胞比率和全身免疫炎症指数。对所有癌细胞的浸润深度进行了测量：结果：在多个血液参数中发现了差异。侵袭深度与中性粒细胞计数（ρ = -0.68，p = 0.017）、淋巴细胞计数（ρ = 0.72，p = 0.011) 、中性粒细胞与淋巴细胞比率 (ρ = -0.65, p = 0.025)、血小板与淋巴细胞比率 (ρ = -0.73, p = 0.013) 和全身免疫炎症指数 (ρ = -0.67, p = 0.037)：结论：诱导型一氧化氮合酶似乎在 OSCC 的侵袭和进展中起着重要作用，这可能与外周血和全身炎症生物标志物所显示的免疫炎症细胞动态变化有关。

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引用次数: 0

Evaluation of possible role of fluoride in pathogenesis of oral submucous fibrosis: A pilot study 评估氟在口腔黏膜下纤维化发病机制中的可能作用：试点研究

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-02-28 DOI: 10.1111/jop.13527

Gururaj Arakeri, Vishal Rao US, Shekar Patil, Sateesh Kunigal, Roopa Reddy, Murugesan Krishnan, Beverley Hale, Peter A. Brennan

Background

Oral submucous fibrosis (OSMF) is a potentially malignant disorder. Although areca nut chewing is an established risk factor, its low prevalence among nut chewers indicates additional factors likely facilitates pathogenesis. We recently demonstrated high fluoride levels in smokeless tobacco products and hypothesized a potential pathological role of fluoride in OSMF. Further exploring this novel role, this study compared fluoride levels in tissue, serum, and saliva samples from OSMF patients and healthy controls.

Methods

The ethically approved study included 25 clinically confirmed OSMF patients and 25 healthy matched controls. OSMF cases underwent buccal mucosal incisional biopsy, while controls had buccal mucosa tissue sampling during third molar removal. Fasting venous blood and unstimulated saliva were collected. Fluoride levels were analysed using ion chromatography and expressed as median (IQR).

Results

OSMF cases showed significantly higher fluoride concentrations compared with controls in tissue biopsies (30.1 vs. 0 mg/kg, p < 0.0001), serum (0.4 vs. 0 mg/L, p = 0.005) and saliva (1.3 vs. 0 mg/L, p < 0.0001). Majority (68%) of controls had undetectable fluoride levels across all samples. Tissue fluoride weakly correlated with OSMF severity (r = −0.158, p = 0.334).

Conclusion

The preliminary findings demonstrated increased tissue fluoride levels in OSMF patients compared with healthy controls. Along with a previous study showing high fluoride content in smokeless tobacco products, these findings provided early evidence suggesting fluoride could play a contributory role in OSMF pathogenesis. Further large-scale investigation is warranted to definitively establish whether the association between fluoride exposure and OSMF is indicative of causation.

背景：口腔黏膜下纤维化（OSMF口腔黏膜下纤维化（OSMF）是一种潜在的恶性疾病。虽然咀嚼槟榔是一个既定的风险因素，但咀嚼槟榔者的发病率较低，这表明还有其他因素可能会促进发病。我们最近发现无烟烟草制品中氟含量很高，并假设氟在 OSMF 中可能起着病理作用。为了进一步探索这种新作用，本研究比较了OSMF患者和健康对照组的组织、血清和唾液样本中的氟含量：这项经伦理批准的研究包括 25 名临床确诊的 OSMF 患者和 25 名健康对照组。OSMF患者接受了颊黏膜切口活检，而对照组则在拔除第三磨牙时进行了颊黏膜组织取样。采集了空腹静脉血和未受刺激的唾液。采用离子色谱法分析氟含量，并以中位数（IQR）表示：结果：与对照组相比，OSMF 病例的组织活检结果显示氟浓度明显更高（30.1 对 0 毫克/千克，P 结论：OSMF 病例的组织活检结果显示氟浓度明显更高（30.1 对 0 毫克/千克，P 结论）：初步研究结果表明，与健康对照组相比，OSMF 患者组织中的氟含量有所增加。之前的一项研究显示，无烟烟草制品中的氟含量较高，这些发现提供了早期证据，表明氟可能在 OSMF 的发病机制中起着促进作用。要明确确定氟暴露与OSMF之间的关联是否表明存在因果关系，还需要进行进一步的大规模调查。

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引用次数: 0

Expression of TNF-α, omentin-1, and IL-6 before and after adjunctive treatment with a bioactive antimicrobial peptide periodontal gel 生物活性抗菌肽牙周凝胶辅助治疗前后 TNF-α、网织蛋白-1 和 IL-6 的表达情况

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-02-25 DOI: 10.1111/jop.13518

Bo Zhang, Lulu Wang, Chang Liu

Background

The objective of this study was to evaluate and compare the expression levels of TNF-α, omentin-1, and IL-6 in periodontitis patients before and after treatment with biological antimicrobial peptide (AMP) periodontal gel.

Methods

There involved 86 periodontitis patients admitted to our hospital from January 2020 to March 2021. They were equally and randomly distributed into the study group and the control group. The efficacy and adverse reactions were compared between the two groups after treatment, Additionally, the sulcus bleeding index (SBI), plaque index (PLI), gingival index (GI), periodontal probing depth (PD), and levels of TNF-α, omentin-1, and IL-6 were measured before and after treatment.

Results

After treatment, the total effective rate of the study group was significantly higher than that of the control group (p < 0.05), while the scores of four indicators (SBI, PLI, GI, and PD) and the levels of TNF-α, omentin-1, and IL-6 in the study group were evidently lower than the control group (p < 0.05). The study group had 1 case of mild irritant reaction, with an adverse reaction rate of 2.33% (1/43). And the control group had 1 case of nausea and 1 case of allergy, with an adverse reaction rate of 4.65% (2/43). The adverse reactions demonstrated no statistical difference between the two groups (χ² = 0.345, p = 0.557).

Conclusions

The levels of TNF-α and IL-6 were highly expressed before the auxiliary therapy of biological AMP periodontal gel for periodontitis, alongside low expression of omentin-1. Subsequently, the biological antibacterial polypeptide periodontal gel demonstrated efficacy in the treatment of periodontitis.

背景本研究旨在评估和比较牙周炎患者在使用生物抗菌肽（AMP）牙周凝胶治疗前后TNF-α、网状素-1和IL-6的表达水平。研究组和对照组的患者人数相等，随机分配。比较两组患者治疗后的疗效和不良反应，并测定两组患者治疗前后的龈沟出血指数（SBI）、牙菌斑指数（PLI）、牙龈指数（GI）、牙周探诊深度（PD）以及TNF-α、网状素-1和IL-6的水平。结果治疗后，研究组的总有效率明显高于对照组（P <0.05），而研究组的四项指标（SBI、PLI、GI、PD）评分和 TNF-α、网状素-1、IL-6 水平明显低于对照组（P <0.05）。研究组出现 1 例轻度刺激反应，不良反应率为 2.33%（1/43）。对照组有 1 例恶心和 1 例过敏，不良反应率为 4.65%（2/43）。结论在使用生物 AMP 牙周凝胶辅助治疗牙周炎前，TNF-α 和 IL-6 的表达水平较高，而网状素-1 的表达水平较低。随后，生物抗菌多肽牙周凝胶显示出治疗牙周炎的疗效。

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引用次数: 0

Professor Emeritus Newell W. Johnson, CMG; FMedSci 荣誉教授纽维尔-约翰逊（Newell W. Johnson），CMG；FMedSci：MDSc，PhD，FDSRCS（Eng），FRACDS，FRCPath（UK），FFOP（RCPA），FOMAA，FICD，FHEA（UK）。

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-02-22 DOI: 10.1111/jop.13519

Saman Warnakulasuriya, Lakshman Samaranayake, W. M. Tillakaratne

引用次数: 0

A call for the development of a clinical tool to quantify lifetime betel quid exposure, inspired by the pack-years concept in smoking—Betel-years 受 "吸烟-槟榔-年 "中 "包-年 "概念的启发，呼吁开发一种临床工具来量化槟榔的终生暴露量。

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-02-20 DOI: 10.1111/jop.13521

Hamrish Kumar Rajakumar, Varsha Coimbatore Sathyabal

引用次数: 0

Ameloblastic carcinoma: A systematic review 绒毛膜细胞癌：系统综述。

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-02-18 DOI: 10.1111/jop.13517

Liam Robinson, Lucas Guimarães Abreu, Felipe Paiva Fonseca, Keith D. Hunter, Melvin A. Ambele, Willie F. P. van Heerden

Background

Ameloblastic carcinoma (AC) is the most common odontogenic malignancy, constituting approximately 30% of cases in this category. Literature is sparse on malignant odontogenic neoplasms, with a large proportion of current knowledge derived from case reports or small case series.

Methods

A systematic review of case series/case reports of AC was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Statement guidelines. Demographic and clinical information, including duration of the lesion, location, clinical presentation and radiologic features, were analysed. Additionally, the origin of the lesion (primary/secondary), Ki-67 proliferation index, treatment performed, metastasis, tumour recurrence and prognosis were collected for analysis.

Results

A total of 126 studies, including 285 individual cases of AC, were included in this review. Patients presented with a near-equal distribution of painless and painful swellings. ACs presented at a median age of 45 years, with a male-to-female ratio of 1:2. The mandible was most frequently involved, with rare cases extending to involve more than one region, including crossing the midline. Although most lesions presented with poorly-demarcated borders (52.6%), unilocular lesions with well-demarcated borders (47.4%) comprised a substantial number in the sample. The proliferation index was only reported in 27 cases, with a mean score of 42% and a wide range. The probability of tumour recurrence increased, and the survival probability decreased with prolonged follow-up duration.

Conclusion

This study provides more comprehensive, up-to-date descriptive data on these rare odontogenic malignancies, aiding clinicians and Pathologists with the diagnosis and surgeons in their management of cases.

背景：无牙细胞癌（AC）是最常见的牙源性恶性肿瘤，约占该类病例的30%。有关恶性牙源性肿瘤的文献很少，目前大部分知识来自病例报告或小型病例系列：方法：根据《系统综述和元分析首选报告项目》（PRISMA）声明指南，对 AC 病例系列/病例报告进行了系统综述。分析了人口统计学和临床信息，包括病变持续时间、位置、临床表现和放射学特征。此外，还收集了病变来源（原发性/继发性）、Ki-67 增殖指数、治疗情况、转移情况、肿瘤复发情况和预后情况等信息进行分析：本综述共纳入了 126 项研究，包括 285 例 AC 病例。患者的无痛性肿胀和疼痛性肿胀分布几乎相等。中位年龄为 45 岁，男女比例为 1:2。下颌骨最常受累，少数病例可累及多个区域，包括跨越中线。虽然大多数病变的边界分界不清（52.6%），但在样本中，边界分界清晰的单眼病变（47.4%）也占了相当大的比例。仅有 27 个病例报告了增殖指数，平均值为 42%，范围很广。随着随访时间的延长，肿瘤复发的概率增加，生存概率降低：这项研究为这些罕见的牙源性恶性肿瘤提供了更全面、最新的描述性数据，有助于临床医生和病理学家进行诊断，也有助于外科医生处理病例。

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引用次数: 0

Ultrasonography use for tongue cancer management: A scoping review 用于舌癌治疗的超声波检查：范围综述。

IF 3.3 3区医学 Q1 Medicine

Journal of Oral Pathology & Medicine

Pub Date : 2024-02-14 DOI: 10.1111/jop.13515

Luiz Cláudio Pires Duarte, Karlayle Teixeira, Barbara Magalhães Figueiredo Dias, Felipe Paiva Fonseca, Denise Vieira Travassos, Chané Smit, Maurício Augusto Aquino de Castro, Aline Araujo Sampaio

Background

Tongue cancer is associated with debilitating diseases and poor prognostic outcomes. The use of imaging techniques like ultrasonography to assist in the clinical management of affected patients is desirable, but its reliability remains debatable. Therefore, the aim of this study is to investigate the importance of ultrasound use for the clinicopathological management of tongue cancer.

Methods

A scoping review was carried out using specific search strategies in the following electronic databases: PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar. Collected data included bibliographical information, study design, ultrasound equipment, the aim of the ultrasonography use, the timing of ultrasound use during oncological treatment (pre-, trans-, and/or post-operatively), and the advantages and disadvantages of the use of the ultrasound.

Results

A total of 47 studies were included in this review after following the selection process. The majority of the studies investigated the use of ultrasound pre-operatively for the investigation of lymph node metastases or to determine the tumor thickness and depth of invasion. The sensitivity, specificity, and accuracy of ultrasound to determine clinical lymph node metastases ranged from 47% to 87.2%, from 84.3% to 95.8%, and from 70% to 86.2%, respectively. The sensitivity and specificity to determine the microscopic depth of invasion were 92.3% and from 70.6% to 82.1%, respectively.

Conclusion

Ultrasonography seems to be a reliable imaging technique for the investigation of important prognostic parameters for tongue cancer, including depth of invasion and lymph node metastases.

背景：舌癌是一种使人衰弱和预后不良的疾病。使用超声波等成像技术来协助对患者进行临床管理是可取的，但其可靠性仍有待商榷。因此，本研究旨在探讨超声波在舌癌临床病理管理中的重要性：方法：采用特定的检索策略，在以下电子数据库中进行了范围综述：PubMed/MEDLINE、Scopus、Web of Science 和 Google Scholar。收集的数据包括文献信息、研究设计、超声设备、使用超声的目的、肿瘤治疗期间使用超声的时间（术前、术中和/或术后）以及使用超声的优缺点：经过筛选，共有 47 项研究被纳入本综述。大部分研究调查了术前使用超声波检查淋巴结转移或确定肿瘤厚度和侵犯深度的情况。超声波确定临床淋巴结转移的敏感性、特异性和准确性分别为 47% 至 87.2%、84.3% 至 95.8% 和 70% 至 86.2%。确定微观侵犯深度的敏感性和特异性分别为92.3%和70.6%至82.1%：结论：超声波检查似乎是一种可靠的成像技术，可用于检测舌癌的重要预后参数，包括浸润深度和淋巴结转移。

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引用次数: 0