Journal of Oral Pathology & Medicine最新文献_第6页

Clinical Features Associated With Malignant Transformation of Low-Grade Dysplasia 低级别不典型增生恶性转化的临床特征。

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-10-06 DOI: 10.1111/jop.70070

Denise M. Laronde, Matt Berkowitz, A. Ross Kerr, Erinn M. Hade, Mutita Siriruchatanon, Miriam P. Rosin, Stella K. Kang

Background

Inferring risk for malignant transformation (MT) in patients with lesions diagnosed as mild or moderate oral epithelial dysplasia (low-grade OED) remains challenging. We developed two models assessing the risk of progression to high-grade OED (severe dysplasia or carcinoma in situ) or OSCC in patients with low-grade OED lesions.

Methods

We included demographic, risk habit and clinical data from participants with low-grade OED lesions enrolled in the BC Oral Cancer Prevention Program's Oral Cancer Prediction Longitudinal study. Cox proportional hazard models were fit to estimate the effects of anatomic site and toluidine blue findings and adjusted for confounders, as both are associated with MT in the literature but without a North American-specific cohort analysis. Our primary model included both variables of interest. A secondary model included only anatomic site since toluidine blue is not in widespread use.

Results

Five hundred and thirty-four participants with 605 lesions met final inclusion criteria, with 339 mild and 266 moderate OED at baseline. In the primary model, lesions at a high-risk anatomic site or with positive toluidine blue staining were associated with a 2.6 and 2.4-fold increased risk of progression, respectively. In the second model that did not incorporate toluidine blue, high-risk anatomic site remained a highly associated risk factor (2.7-fold increased risk of progression).

Conclusion

Lesion anatomic site is associated with higher risk of MT for the general practitioner, while a specialist with access to toluidine blue results can assume additional risk associated with positive staining. These models may inform decisions for surveillance and intervention for OED.

背景：推断轻度或中度口腔上皮发育不良（低级别OED）患者发生恶性转化（MT）的风险仍然具有挑战性。我们开发了两种模型来评估低级别OED患者进展为高级别OED（严重发育不良或原位癌）或OSCC的风险。方法：我们纳入了BC省口腔癌预防项目口腔癌预测纵向研究中低级别OED病变参与者的人口统计学、风险习惯和临床数据。Cox比例风险模型适合于估计解剖部位和甲苯胺蓝结果的影响，并对混杂因素进行了调整，因为两者在文献中都与MT相关，但没有北美特定的队列分析。我们的主要模型包括两个感兴趣的变量。二级模型只包括解剖部位，因为甲苯胺蓝没有广泛使用。结果：534名受试者605个病灶符合最终入选标准，其中339例为轻度OED， 266例为中度OED。在初级模型中，高风险解剖部位的病变或甲苯胺蓝染色阳性的病变分别与2.6倍和2.4倍的进展风险增加相关。在第二种不含甲苯胺蓝的模型中，高危解剖部位仍然是高度相关的危险因素（进展风险增加2.7倍）。结论：对于全科医生来说，病变解剖部位与MT的高风险相关，而获得甲苯胺蓝结果的专科医生可能会承担与阳性染色相关的额外风险。这些模型可以为OED的监测和干预决策提供信息。

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引用次数: 0

Pemphigus Vulgaris Scoring Systems: A Scoping Review 寻常性天疱疮评分系统：范围审查。

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-10-03 DOI: 10.1111/jop.70071

Sue-Ching Yeoh, Stephen Adelstein, Omar Kujan

Background

Pemphigus vulgaris is a rare autoimmune blistering condition characterised by mucocutaneous lesions secondary to acantholysis. Assessment of disease activity, severity, and treatment response is crucial for guiding management and research. Multiple clinical scoring systems have been developed for pemphigus vulgaris; however, consensus on their optimal use is lacking. This scoping review aims to identify, evaluate, and summarise the clinical scoring systems used in pemphigus vulgaris, focusing on validity, reliability, and application in clinical practice and research.

Methods

A comprehensive literature search was conducted using electronic databases (PubMed (Medline), Embase, Web of Science, Scopus, and Cochrane Library) as well as grey literature to identify studies describing clinical scoring systems for pemphigus vulgaris. Data on scoring system components, validity, clinical applicability, and limitations were extracted and synthesised.

Results

The review identified several scoring systems, including the Pemphigus Disease Area Index, Autoimmune Bullous Skin Disorder Intensity Score, and other less commonly used tools. Scoring systems varied in design, with key differences noted in assessment domains, including mucosal versus cutaneous involvement, patient-reported outcomes, and usability.

Conclusion

Current clinical scoring systems for pemphigus vulgaris provide frameworks for disease assessment but exhibit variability in scope, validation, and practical implementation. Further development to incorporate emerging biomarkers and quality of life, as well as encompass all clinical subsites, will enhance their utility in guiding patient care and advancing research. This review highlights the need for consensus on a universal scoring system tailored to the multifaceted nature of pemphigus vulgaris.

背景：寻常型天疱疮是一种罕见的自身免疫性水疱，其特征是继发于棘层松解的皮肤粘膜病变。评估疾病活动性、严重程度和治疗反应对指导管理和研究至关重要。多种临床评分系统已开发寻常型天疱疮；然而，对它们的最佳使用还缺乏共识。本综述旨在识别、评估和总结用于寻常型天疱疮的临床评分系统，重点关注有效性、可靠性及其在临床实践和研究中的应用。方法：通过电子数据库（PubMed （Medline）、Embase、Web of Science、Scopus和Cochrane Library）以及灰色文献进行全面的文献检索，以确定描述寻常型天疱疮临床评分系统的研究。提取和综合评分系统组成、有效性、临床适用性和局限性的数据。结果：本综述确定了几种评分系统，包括天疱疮疾病面积指数、自身免疫性大疱性皮肤疾病强度评分和其他不太常用的工具。评分系统在设计上各不相同，在评估领域存在关键差异，包括粘膜与皮肤受累、患者报告的结果和可用性。结论：目前的寻常型天疱疮临床评分系统为疾病评估提供了框架，但在范围、有效性和实际实施方面存在差异。进一步发展纳入新兴生物标志物和生活质量，以及涵盖所有临床亚位点，将增强其在指导患者护理和推进研究方面的效用。这篇综述强调需要共识的普遍评分系统量身定制寻常性天疱疮的多方面性质。

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引用次数: 0

Clinicopathological Profile of Intraosseous Adenoid Cystic Carcinoma of the Jaws: A Systematic Review 颌骨骨内腺样囊性癌的临床病理特征：系统综述。

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-09-23 DOI: 10.1111/jop.70063

Luccas Lavareze, João Figueira Scarini, Reydson Alcides de Lima-Souza, Talita de Carvalho Kimura, Rogério de Oliveira Gondak, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano

Objectives

We aimed to evaluate the clinicopathological features, survival rate, and potential prognostic markers of the jaws' primary intraosseous adenoid cystic carcinoma (PIACC).

Materials and Methods

MEDLINE/PubMed, Scopus, and Embase searches were performed with the keywords “adenoid cystic carcinoma,” and “jaw,” or “maxilla,” or “mandible.” We included articles that evaluated cases diagnosed as PIACC in jaws. Studies with insufficient demographic data, inconclusive histopathologic diagnosis, and appropriate follow-up were excluded. The Joanna Briggs Institute tool was used to assess the risk of bias.

Results

Fifty-five PIACC comprising 27 studies met the inclusion criteria. The mean age of the patients was 56.4 ± 19.6 years with no sex predilection. PIACC showed a strong predilection for the mandible (69.1%), mainly in the posterior segment (40%). The patients presented symptoms in 87.3% of cases. Radiographically, PIACC presented as an ill-defined radiolucent lesion (40%). Most cases showed a cribriform pattern (32.7%). PIACC with a solid growth pattern presented a lower disease-free survival (DFS) (p = 0.040). The 2- and 5-year overall survival rates were 57.9% and 53.8%, respectively. Distant metastases were seen in 3.6% of the patients and were related to a lower DFS (p = 0.043).

Conclusion

PIACC is a rare neoplasm of the jaws with an incidence in the fifth and sixth decades of life and no sex predilection. The posterior mandible was affected in most cases. Solid growth patterns and distant metastases are prognostic factors for a lower DFS.

目的：探讨颌骨原发性骨内腺样囊性癌（PIACC）的临床病理特征、生存率和潜在预后指标。材料和方法：使用关键词“腺样囊性癌”和“颌骨”或“上颌骨”或“下颌骨”进行MEDLINE/PubMed， Scopus和Embase搜索。我们纳入了评估颌骨中诊断为PIACC病例的文章。排除了人口统计资料不足、组织病理学诊断不确定和适当随访的研究。乔安娜布里格斯研究所的工具被用来评估偏见的风险。结果：55项PIACC包括27项研究符合纳入标准。患者平均年龄56.4±19.6岁，无性别偏好。PIACC对下颌骨有强烈的偏好（69.1%），主要在后段（40%）。87.3%的患者出现症状。放射学上，PIACC表现为界限不清的放射透明病变（40%）。以筛网型居多（32.7%）。固定生长模式的PIACC无病生存期（DFS）较低（p = 0.040）。2年和5年总生存率分别为57.9%和53.8%。3.6%的患者出现远处转移，并与较低的DFS相关（p = 0.043）。结论：PIACC是一种罕见的颌骨肿瘤，多发于五六十岁，无性别倾向。后下颌骨在大多数情况下受到影响。固体生长模式和远处转移是低DFS的预后因素。

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引用次数: 0

Elevated N6-Methyladenosine (m6A)-RNA-Methylation During Oral Carcinogenesis 口腔癌发生过程中n6 -甲基腺苷(m6A)- rna甲基化升高。

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-09-22 DOI: 10.1111/jop.70066

Zhiming Qin, Yanting Chi, Xinpei Wang, Jing Yan, Xinning Zhang, Binbin Li

Background/Purpose

Oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) encompass a series of molecular events in the malignant transformation process, ranging from simple epithelial hyperplasia to mild, moderate, and severe dysplasia. N6-methyladenosine (m6A)-RNA methylation participates in the regulation of the tumorigenesis of various malignant tumors, yet the roles played by m6A-RNA methylation in OED and OSCC remain unclear. Therefore, this study focused on investigating OED and OSCC from an epigenetic perspective, aiming to elucidate the underlying molecular mechanisms of malignant transformation.

Materials and Methods

Laser microdissection was performed on OED and OSCC samples. Methylated RNA immunoprecipitation sequencing (MeRIP-Seq) and RNA sequencing (RNA-seq) were applied to establish comprehensive profiles of m6A methylation modifications and gene expression patterns and to identify differentially modified/expressed genes in OED and OSCC.

Results

We presented the overall modification/expression profiles of m6A-RNA-methylation in OED and OSCC. Four hypermethylated genes and 11 hypomethylated genes were found in both OED and OSCC, together with the expression of 107 upregulated and 37 downregulated genes. The most common motifs GRAGRA (R = A/G) of the OED and OSCC methylation sites were mainly located in coding and stop codon regions. In the stable group, C4B, DNAH9, and NCALD all exhibited hypermethylated and upregulated, and the overall survival rate of patients with high expression of these genes was higher than that of patients with low-level expression.

Conclusion

Our study revealed that the level of m6A-RNA methylation in the epithelial tissues of OED and OSCC was higher than that in oral normal epithelium, suggesting that the methylation modification might be involved in the occurrence of OED and its progression to OSCC. Furthermore, hypermethylation and upregulated expression of C4B, DNAH9, and NCALD were associated with a favorable prognosis in these diseases.

背景/目的：口腔上皮异常增生（OED）和口腔鳞状细胞癌（OSCC）在恶性转化过程中包含一系列分子事件，从单纯上皮增生到轻度、中度和重度异常增生。n6 -甲基腺苷(m6A)-RNA甲基化参与多种恶性肿瘤发生的调控，但m6A-RNA甲基化在OED和OSCC中所起的作用尚不清楚。因此，本研究重点从表观遗传学角度对OED和OSCC进行研究，旨在阐明其恶性转化的潜在分子机制。材料和方法：对OED和OSCC样品进行激光显微解剖。应用甲基化RNA免疫沉淀测序（MeRIP-Seq）和RNA测序（RNA-seq）建立m6A甲基化修饰和基因表达模式的综合图谱，并鉴定OED和OSCC中差异修饰/表达的基因。结果：我们在OED和OSCC中获得了m6a - rna甲基化的总体修饰/表达谱。在OED和OSCC中均发现4个高甲基化基因和11个低甲基化基因，同时表达107个上调基因和37个下调基因。OED和OSCC甲基化位点最常见的基序GRAGRA （R = A/G）主要位于编码和停止密码子区。在稳定组中，C4B、DNAH9和NCALD均表现出高甲基化和上调，且这些基因高表达的患者的总生存率高于低表达的患者。结论：我们的研究发现，m6A-RNA在OED和OSCC上皮组织中的甲基化水平高于口腔正常上皮，提示甲基化修饰可能参与了OED的发生和向OSCC的发展。此外，C4B、DNAH9和NCALD的高甲基化和上调表达与这些疾病的良好预后相关。

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引用次数: 0

Why Oral Health Deserves a Seat at the Global Health Table 为什么口腔健康应该在全球健康的桌子上占有一席之地。

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-09-21 DOI: 10.1111/jop.70065

Chukwuemeka L. Anyikwa, Peter A. Brennan, Chukwuebuka E. Ogwo

Oral diseases affect billions worldwide yet remain sidelined in both national and global health policies. This oversight has perpetuated disparities in care access, particularly in low- and middle-income countries. The separation of oral health from broader healthcare systems is illogical and dangerous, given oral health's deep connections to systemic health. This commentary calls for the integration of oral health into primary care and its recognition as a fundamental health right. Essential dental services must be incorporated into universal health coverage (UHC), financial barriers dismantled, and policy frameworks updated. A paradigm shift is essential to position oral health at the heart of global health policy and noncommunicable disease (NCD) prevention strategies.

口腔疾病影响着全世界数十亿人，但在国家和全球卫生政策中仍然处于次要地位。这种疏忽使获得医疗服务的差距长期存在，特别是在低收入和中等收入国家。考虑到口腔健康与全身健康的深层联系，将口腔健康与更广泛的卫生保健系统分离是不合逻辑的，也是危险的。本评论呼吁将口腔卫生纳入初级保健，并将其视为一项基本健康权利。必须将基本牙科服务纳入全民健康覆盖，消除财政障碍，更新政策框架。要将口腔健康置于全球卫生政策和非传染性疾病预防战略的核心位置，就必须转变思维模式。

引用次数: 0

Dental Pulp Mesenchymal Stem Cell-Secretome Gel Reverse Areca Nut Induced Oral Submucous Fibrosis in Mice: A Pilot Study 牙髓间充质干细胞-分泌组凝胶逆转槟榔诱导的小鼠口腔黏膜下纤维化：一项初步研究。

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-09-18 DOI: 10.1111/jop.70064

Nishant Mante, Supriya Kheur, Avinash Sanap, Avinash Kharat, Pranjali Potdar, Poonam Suryawanshi, Ravindra Badhe, Vaishali Undale, Nitika Monga, Ramesh Bhonde

Objectives

Oral submucous fibrosis is a pre-malignant disorder caused by habitual areca nut consumption. This pilot study investigated the therapeutic potential of dental pulp mesenchymal stem cell-secretome chitosan gel in a mice model of areca nut extract-induced oral submucous fibrosis.

Materials and Methods

Angiogenic potential of dental pulp mesenchymal stem cell-secretome was validated using a chick yolk sac membrane assay. Oral submucous fibrosis was induced in male Swiss albino mice (n = 40) via intraoral areca nut extract administration for 3 months. Post-induction, animals were divided into disease control, DPMSCs-S, and DPMSCs-S gel groups. Treatments were administered intraorally twice weekly for 1 month. Therapeutic efficacy was assessed through measurements of mouth opening, histopathology, oxidative stress markers (LDH, MDA, SOD), and fibrotic gene expression (COL1, COL3, α-SMA).

Results

Dental pulp mesenchymal stem cells’ secretome contains pro-angiogenic growth factors. Dental pulp mesenchymal stem cells’ secretome gel significantly improved mouth opening, restored epithelial architecture, and reduced collagen deposition. Histological staining and gene expression analyses confirmed the reversal of fibrosis and downregulation of COL1, COL3, and α-SMA. Additionally, the gel reduced LDH and MDA levels and enhanced SOD activity, indicating antioxidant effects. The gel showed superior efficacy over the secretome alone.

Conclusion

DPMSCs-S gel demonstrates significant anti-fibrotic, antioxidant, and regenerative potential in reversing ANE-induced OSMF in mice. These findings warrant further investigation into larger, long-term preclinical studies.

目的：口腔黏膜下纤维化是一种由习惯性槟榔果食用引起的恶性前病变。本初步研究探讨牙髓间充质干细胞分泌组壳聚糖凝胶在槟榔提取物诱导的口腔黏膜下纤维化小鼠模型中的治疗潜力。材料和方法：利用鸡黄囊膜实验验证牙髓间充质干细胞分泌组的血管生成潜能。用槟榔提取物口服3个月诱导雄性瑞士白化小鼠（n = 40）口腔黏膜下纤维化。诱导后将动物分为疾病对照组、DPMSCs-S组和DPMSCs-S凝胶组。治疗方法为每周口服2次，持续1个月。通过张口、组织病理学、氧化应激标志物（LDH、MDA、SOD）和纤维化基因表达（COL1、COL3、α-SMA）评估治疗效果。结果：牙髓间充质干细胞分泌组含有促血管生成生长因子。牙髓间充质干细胞分泌组凝胶显著改善口腔张开，修复上皮结构，减少胶原沉积。组织学染色和基因表达分析证实了纤维化逆转和COL1、COL3和α-SMA的下调。此外，凝胶降低LDH和MDA水平，提高SOD活性，表明抗氧化作用。与单独使用分泌组相比，凝胶显示出更好的疗效。结论：DPMSCs-S凝胶在逆转ane诱导的小鼠OSMF中具有显著的抗纤维化、抗氧化和再生潜力。这些发现值得进一步进行更大规模、长期的临床前研究。

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引用次数: 0

Prevalence of Oral Alterations and Correlation Between Oral and Cutaneous Neurofibromas in Neurofibromatosis Type 1: A Retrospective Case–Control Study 1型神经纤维瘤病患者口腔改变的患病率及口腔和皮肤神经纤维瘤的相关性：一项回顾性病例对照研究

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-09-17 DOI: 10.1111/jop.70056

Pâmella de Pinho Montovani, Gabriela Pizão Werneck Moreira da Costa, Rafaela Elvira Rozza-de-Menezes, Karin Soares Cunha

Objective

The aim of this study was to determine the prevalence of oral alterations detectable through physical examination in NF1 individuals. Additionally, we assessed the correlation between the number of oral and cutaneous neurofibromas.

Design

This retrospective study evaluated oral alterations in individuals with and without NF1. In the NF1 group, associations between oral and cutaneous neurofibromas, age, sex, pregnancy, and family history of NF1 were assessed.

Results

A total of 327 participants were evaluated (81 with NF1 and 246 controls). Oral mucosal alterations (92.6% vs. 79.3%) and exostoses (12.3% vs. 4.5%) were significantly more prevalent in the NF1 group. The most frequent oral alterations were enlarged fungiform papillae (46.9% vs. 8.1%), coated tongue (45.7% vs. 29.3%), neurofibromas (38.3% versus none), physiological melanin pigmentation (30.9% vs. 10.6%), and exostoses (12.3% vs. 4.5%). Oral neurofibromas were more prevalent in older individuals, without a family history of NF1, and those with multiple cutaneous neurofibromas.

Conclusions

Enlarged fungiform papillae and oral neurofibromas are the most common oral alterations detectable through physical examination in NF1. Coated tongue, physiological melanin pigmentation, and exostoses were also more frequent in NF1. The number of oral and cutaneous neurofibromas is correlated. These findings underscore the necessity of regular oral assessments in NF1 individuals.

目的：本研究的目的是确定NF1个体通过体检可检测到的口腔改变的患病率。此外，我们评估了口腔和皮肤神经纤维瘤数量之间的相关性。设计：本回顾性研究评估了NF1患者和非NF1患者的口腔改变。在NF1组中，评估了口腔和皮肤神经纤维瘤、年龄、性别、妊娠和NF1家族史之间的关系。结果：共有327名参与者被评估（81名NF1患者和246名对照组）。口腔黏膜改变（92.6% vs. 79.3%）和外露（12.3% vs. 4.5%）在NF1组中更为普遍。最常见的口腔病变是真菌状乳头肿大（46.9%比8.1%）、舌膜覆盖（45.7%比29.3%）、神经纤维瘤（38.3%比无）、生理性黑色素沉着（30.9%比10.6%）和外生瘤（12.3%比4.5%）。口腔神经纤维瘤在没有NF1家族史的老年人和多发性皮肤神经纤维瘤患者中更为普遍。结论：真菌状乳头状瘤和口腔神经纤维瘤是NF1患者体格检查中最常见的口腔病变。舌包膜、生理性黑色素沉着和外生骨瘤在NF1中也更为常见。口腔和皮肤神经纤维瘤的数量是相关的。这些发现强调了对NF1个体进行定期口腔评估的必要性。

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引用次数: 0

The PI3K Inhibitor HCD Promotes Caspase Activation in Head and Neck Squamous Cells by Upregulating the Extrinsic and Intrinsic Apoptosis Pathways PI3K抑制剂HCD通过上调外源性和内源性凋亡途径促进头颈部鳞状细胞中Caspase的激活。

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-09-15 DOI: 10.1111/jop.70060

Leong-Perng Chan, Ya-Ping Tseng, Hui-Ching Wang, Chen-Yu Chien, Che-Wei Wu, Ling-Feng Wang, Tung-Wen Yen, Po-Chun Wang, Chih-Chuang Liaw, Chia-Hua Liang

Background

16-hydroxycleroda-3,13-dien-15,16-olide (HCD), a compound isolated from Polyalthia longifolia var. pendula, has been identified as a PI3K inhibitor. P. longifolia var. pendula is recognized for its diverse pharmacological properties, including antimicrobial, hypotensive, anti-inflammatory, and cytotoxic activities. Considering the pivotal role of PI3K in the regulation of apoptosis in cancer cells, this study aims to investigate the apoptotic effects induced by HCD in head and neck cancer cell models.

Methods

The study focused on investigating the mechanism through which HCD induces apoptosis in oral squamous cell carcinoma (OSCC) using SCC25 and SCC180 cells. These cells were treated with HCD at IC₂₀, IC₅₀, and IC₈₀ concentrations over periods of 24, 48, and 72 h. Assessments included cell viability, oxidative stress levels using MitoSOX and CellROX, and the analysis of gene and protein expressions related to apoptosis via immunofluorescence staining, flow cytometry, RT-PCR, and western blotting.

Results

The results demonstrated that HCD significantly increased the sub-G₁ phase cell population, suppressed clonogenic activity, and promoted mitochondrial ROS production, accompanied by a reduction in glutathione levels. HCD also activated cytochrome c (cyto. c) release and Bax expression while downregulating Bcl-2 expression. Notably, in SCC25 cells, HCD induced apoptosis through the TNF-α/TNF-R and FasL/Fas death domains, leading to caspase cascade activation. Moreover, HCD showed dose-dependent growth inhibition of SCC25 cells, both alone and combined with cisplatin, by enhancing caspase-3 expression.

Conclusion

This investigation into HCD's molecular mechanisms in OSCC cells offers insight into developing effective anticancer therapies, highlighting its role in apoptosis induction through oxidative stress, mitochondrial pathways, and death receptor signaling.

背景：16-hydroxycleroda-3,13-dien-15,16-olide （HCD）是从长叶蓼中分离得到的一种化合物，已被鉴定为PI3K抑制剂。长叶黄因其多种药理特性而被公认，包括抗菌、降压、抗炎和细胞毒活性。考虑到PI3K在肿瘤细胞凋亡调控中的关键作用，本研究旨在探讨HCD对头颈部肿瘤细胞模型的凋亡作用。方法：利用SCC25和SCC180细胞，研究HCD诱导口腔鳞状细胞癌（OSCC）细胞凋亡的机制。这些细胞分别用浓度为IC20、IC50和IC80的HCD处理24、48和72小时。评估包括使用MitoSOX和CellROX检测细胞活力、氧化应激水平，并通过免疫荧光染色、流式细胞术、RT-PCR和western blotting分析与凋亡相关的基因和蛋白表达。结果：结果表明，HCD显著增加亚g1期细胞群，抑制克隆生成活性，促进线粒体ROS产生，并伴有谷胱甘肽水平降低。HCD还能激活细胞色素c。c)释放和Bax表达，下调Bcl-2表达。值得注意的是，在SCC25细胞中，HCD通过TNF-α/TNF- r和FasL/Fas死亡结构域诱导细胞凋亡，导致caspase级联激活。此外，HCD通过提高caspase-3的表达，显示出剂量依赖性的SCC25细胞生长抑制作用，无论是单独使用还是与顺铂联合使用。结论：对HCD在OSCC细胞中的分子机制的研究为开发有效的抗癌疗法提供了见解，突出了其通过氧化应激、线粒体途径和死亡受体信号传导诱导细胞凋亡的作用。

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引用次数: 0

A Comparative Analysis of Clinical Aspects of Conventional Polymorphous Adenocarcinoma and Cribriform Adenocarcinoma of Salivary Glands: A Systematic Review 常规涎腺多形性腺癌与筛状腺癌临床比较分析：系统综述。

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-09-15 DOI: 10.1111/jop.70067

Bruno Romano de Oliveira, Warley Oliveira Silva, Carolina Cavaliéri Gomes, Jean Nunes dos Santos, Fabrício Tinôco Alvim de Souza

Background

Polymorphous adenocarcinoma (PmA) is the second most common malignant neoplasm in minor salivary glands; a subtype of this lesion was described in 2005 with more aggressive behavior, Cribriform Adenocarcinoma of Salivary Glands (CASG).

Objective

To compare the clinical aspects of conventional PmA and CASG originating in minor salivary glands of the oral cavity through the analysis of observational studies reported in the literature between 2005 and 2025.

Method

This systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The review included searches of Pubmed, Lilacs, Scopus, and Web of Science databases. A total of 988 records were identified, and after the selection process, 47 articles were chosen for inclusion.

Results

Females were the most affected (61% in PmA and 73.3% in CASG). The average age variation was 60 in PmA and 57.3 in CASG. The most frequent anatomical location was the palate (42.4%) in PmA and the tongue (46.7%) in CASG. Lymph node metastasis was found in 15.2% in PmA and in 60% in CASG. The most commonly used treatment was surgical excision (72.72%) in PmA and surgical excision and neck dissection (46.67%) in CASG. Recurrence rates were 9.09% in PmA and 33.33% in CASG. The average follow-up period was 21.7 months in PmA and 43.9 in CASG.

Conclusion

Female predilection and average age of 60 years are common between the two tumors. The clinical variables with quantitative differences are anatomical location, lymph node metastasis, treatment modality, and recurrence.

背景：多形态腺癌（PmA）是小唾液腺第二常见的恶性肿瘤；这种病变的一个亚型在2005年被描述为更具侵略性的行为，即唾液腺筛状腺癌（CASG）。目的：通过对2005年至2025年文献报道的观察性研究进行分析，比较传统PmA和起源于口腔小涎腺的CASG的临床特点。方法：本系统评价遵循系统评价和荟萃分析（PRISMA）指南的首选报告项目。该综述包括Pubmed、Lilacs、Scopus和Web of Science数据库的搜索。共确定了988条记录，经过筛选过程，选择了47篇文章纳入。结果：女性受影响最大（PmA为61%，CASG为73.3%）。PmA的平均年龄变化为60，CASG的平均年龄变化为57.3。最常见的解剖位置为上颚（42.4%）和舌部（46.7%）。PmA和CASG的淋巴结转移率分别为15.2%和60%。PmA最常用的治疗方法是手术切除（72.72%），CASG最常用的治疗方法是手术切除加颈部清扫（46.67%）。PmA复发率为9.09%，CASG为33.33%。PmA组平均随访21.7个月，CASG组平均随访43.9个月。结论：两种肿瘤均以女性为主，平均年龄60岁。具有数量差异的临床变量为解剖位置、淋巴结转移、治疗方式和复发。

{"title":"A Comparative Analysis of Clinical Aspects of Conventional Polymorphous Adenocarcinoma and Cribriform Adenocarcinoma of Salivary Glands: A Systematic Review","authors":"Bruno Romano de Oliveira, Warley Oliveira Silva, Carolina Cavaliéri Gomes, Jean Nunes dos Santos, Fabrício Tinôco Alvim de Souza","doi":"10.1111/jop.70067","DOIUrl":"10.1111/jop.70067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Polymorphous adenocarcinoma (PmA) is the second most common malignant neoplasm in minor salivary glands; a subtype of this lesion was described in 2005 with more aggressive behavior, Cribriform Adenocarcinoma of Salivary Glands (CASG).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the clinical aspects of conventional PmA and CASG originating in minor salivary glands of the oral cavity through the analysis of observational studies reported in the literature between 2005 and 2025.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The review included searches of Pubmed, Lilacs, Scopus, and Web of Science databases. A total of 988 records were identified, and after the selection process, 47 articles were chosen for inclusion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Females were the most affected (61% in PmA and 73.3% in CASG). The average age variation was 60 in PmA and 57.3 in CASG. The most frequent anatomical location was the palate (42.4%) in PmA and the tongue (46.7%) in CASG. Lymph node metastasis was found in 15.2% in PmA and in 60% in CASG. The most commonly used treatment was surgical excision (72.72%) in PmA and surgical excision and neck dissection (46.67%) in CASG. Recurrence rates were 9.09% in PmA and 33.33% in CASG. The average follow-up period was 21.7 months in PmA and 43.9 in CASG.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Female predilection and average age of 60 years are common between the two tumors. The clinical variables with quantitative differences are anatomical location, lymph node metastasis, treatment modality, and recurrence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"55 1","pages":"23-31"},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single Nucleotide Polymorphisms as Markers of Genetic Susceptibility for Oral Submucous Fibrosis Risk: A Systematic Review and Meta-Analysis 单核苷酸多态性作为口腔粘膜下纤维化风险遗传易感性的标记：一项系统综述和荟萃分析。

IF 2.3 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine

Pub Date : 2025-09-12 DOI: 10.1111/jop.70054

Divya Gopinath, Cheng Yung On, Chathathayil Mohammedali Shafeeque, Sajesh K. Veettil, Wanninayake M. Tilakaratne

Background

Varied susceptibility to Oral submucous fibrosis (OSF) among individuals exposed to the same environmental variables indicates that genetic variation may contribute as a risk factor in its development. The objective was to comprehensively analyze the association between single gene polymorphisms (SNPs) and the risk of OSF.

Methods

This comprehensive systematic review encompassed all relevant published studies up until June 2024 that examined the influence of gene polymorphisms on the likelihood of OSF. The search was conducted across multiple databases, including Medline, Scopus, and EBSCOhost. Data were pooled in a random-effect meta-analysis where at least two studies on the same SNP tested the same genotyping model. The assessment of heterogeneity was conducted using the I ² statistic. The Q-Genie tool was used to evaluate the quality of the included studies.

Results

Out of the 4573 papers initially searched, only 37 articles met the criteria to be included in this review. A total of 63 SNPs from 27 genes were tested, and 38 SNPs had significant associations. The meta-analysis revealed that five SNPs, including GSTM1 null (OR = 1.90; 1.41–2.56), GSTT1 null (OR = 2.41; 1.64–3.53), MMP3 (−1171; promoter region) (OR = 3.33; 1.45–7.61), XXCR3 (T vs. C) (OR = 1.70 (1.23–2.36)) and CYP1A1 m2 at Ncol site (−) (OR = 4.32; 1.22–15.29), are associated with an increased risk of OSF.

Conclusion

The limited SNPs identified in this review could be used as markers to identify patients at a higher risk of OSF. Further studies are warranted to validate the SNPs, which demonstrate contradictory results among the currently available studies.

背景：暴露于相同环境变量的个体对口腔黏膜下纤维化（OSF）的易感性不同，表明遗传变异可能是其发展的一个危险因素。目的是全面分析单基因多态性（snp）与OSF风险之间的关系。方法：这项全面的系统综述包含了截至2024年6月的所有相关已发表的研究，这些研究检查了基因多态性对OSF可能性的影响。检索是在多个数据库中进行的，包括Medline、Scopus和EBSCOhost。数据汇集在随机效应荟萃分析中，其中至少有两项关于相同SNP的研究测试了相同的基因分型模型。异质性评价采用I2统计量。使用Q-Genie工具评价纳入研究的质量。结果：在最初检索的4573篇论文中，只有37篇符合纳入本综述的标准。共检测了27个基因的63个snp，其中38个snp具有显著相关性。荟萃分析显示，GSTM1 null （OR = 1.90; 1.41-2.56）、GSTT1 null （OR = 2.41; 1.64-3.53）、MMP3（-1171；启动子区）（OR = 3.33; 1.45-7.61）、XXCR3 (T对C) （OR = 1.70(1.23-2.36)）和Ncol位点CYP1A1 m2 (-) （OR = 4.32; 1.22-15.29）等5个snp与OSF风险增加相关。结论：本综述中发现的有限snp可作为识别OSF高危患者的标志物。需要进一步的研究来验证这些snp，这些snp在目前的研究中显示出相互矛盾的结果。

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引用次数: 0