Rodrigo J. Mariño, Carlos Zaror, Pablo Cantú, Gerardo Espinoza
Objective
The aim of this study is to investigate the financial consequences of immediate side effects of antibiotic over-prescription in dentistry from a societal perspective; to improve resource allocation and antibiotic prescribing practices.
Methods
A cost-outcome description study was conducted, employing a decision tree model to estimate the costs arising from antibiotic over-prescription in oral healthcare. The model is based on a review of the relevant literature regarding current antibiotic prescribing practices in dentistry. It estimated the annual antibiotic prescription from 31 233 registered dentists in Chile (i.e., 1 624 428 prescriptions), with 55% of these considered unnecessary. Direct costs from a societal perspective were evaluated over a one-year time horizon, including medical services, lost income, and transportation costs. A sensitivity analysis was performed to assess the robustness of the findings.
Results
The total societal cost of antibiotic over-prescription in dentistry was estimated at CLP: 8545478768 (USD: 9519516), including CLP: 3275870238 (USD: 3649263) for unnecessary prescriptions, and CLP: 5269608530 (USD:5870253) for adverse reactions. The sensitivity analysis indicated that variations in the percentage of unnecessary prescriptions significantly influenced the overall costs, ranging from CLP: 6991755356 (USD: 7788695) to CLP: 10099202180 (USD: 11250337).
Conclusion
The study evaluated the economic burden of antibiotic over-prescription in oral healthcare, in terms of adverse reactions, highlighting the need for better prescribing practices. It suggested that significant cost-savings (USD: 9.5 million) could be achieved by reducing unnecessary antibiotic prescriptions. By addressing this challenge, we can not only alleviate the financial burden on society but also contribute to the global fight against antimicrobial resistance.
{"title":"Costs-Outcome Description Arising From Side Effects due the Over-Prescription of Antibiotics in Oral Healthcare in Chile","authors":"Rodrigo J. Mariño, Carlos Zaror, Pablo Cantú, Gerardo Espinoza","doi":"10.1111/jop.70044","DOIUrl":"10.1111/jop.70044","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study is to investigate the financial consequences of immediate side effects of antibiotic over-prescription in dentistry from a societal perspective; to improve resource allocation and antibiotic prescribing practices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cost-outcome description study was conducted, employing a decision tree model to estimate the costs arising from antibiotic over-prescription in oral healthcare. The model is based on a review of the relevant literature regarding current antibiotic prescribing practices in dentistry. It estimated the annual antibiotic prescription from 31 233 registered dentists in Chile (i.e., 1 624 428 prescriptions), with 55% of these considered unnecessary. Direct costs from a societal perspective were evaluated over a one-year time horizon, including medical services, lost income, and transportation costs. A sensitivity analysis was performed to assess the robustness of the findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The total societal cost of antibiotic over-prescription in dentistry was estimated at CLP: 8545478768 (USD: 9519516), including CLP: 3275870238 (USD: 3649263) for unnecessary prescriptions, and CLP: 5269608530 (USD:5870253) for adverse reactions. The sensitivity analysis indicated that variations in the percentage of unnecessary prescriptions significantly influenced the overall costs, ranging from CLP: 6991755356 (USD: 7788695) to CLP: 10099202180 (USD: 11250337).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study evaluated the economic burden of antibiotic over-prescription in oral healthcare, in terms of adverse reactions, highlighting the need for better prescribing practices. It suggested that significant cost-savings (USD: 9.5 million) could be achieved by reducing unnecessary antibiotic prescriptions. By addressing this challenge, we can not only alleviate the financial burden on society but also contribute to the global fight against antimicrobial resistance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 10","pages":"963-971"},"PeriodicalIF":2.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Despite its widespread use in acne vulgaris treatment, the potential cytological and genotoxic effects of systemic isotretinoin on oral mucosal cells remain poorly understood. This study aimed to investigate the cytological and genotoxic effects of systemic isotretinoin on oral mucosal cells.
Methods
Buccal smear samples were collected from isotretinoin users (n = 20) and controls (n = 20). Cytomorphometric analyses (cell diameter (CD), nuclear diameter (ND), nuclear area (NA), cell area (CA), ND/CD, and NA/CA ratios) and cytological evaluations (nuclear degenerations, binucleation, perinuclear halos) were conducted using Papanicolaou staining. Micronucleus (MN) testing was performed on Feulgen-stained samples.
Results
CD, ND, CA, and NA were significantly higher in the isotretinoin group (p < 0.05), while the ND/CD ratio was reduced (p < 0.05). MN scores and the presence of micronucleated cells (MNed cells) were significantly increased in isotretinoin users (p < 0.05), indicating genotoxic effects. The isotretinoin group showed a lower mean pH (5.8) than controls (6.7) (p < 0.001). No significant differences were linked to isotretinoin duration (less than 6 months (6<) vs. 6 months or more (6≥)) (p > 0.05).
Conclusions
Isotretinoin use induces cytological changes, including increased cell and nuclear sizes, and genotoxic effects, as evidenced by elevated MN formation. Monitoring oral mucosal alterations in isotretinoin users may provide insights into potential side effects.
{"title":"Cytological and Genotoxic Effects of Systemic Isotretinoin on Oral Mucosa Cells","authors":"Alinda Uslu, Hanife Guler Donmez","doi":"10.1111/jop.70048","DOIUrl":"10.1111/jop.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite its widespread use in acne vulgaris treatment, the potential cytological and genotoxic effects of systemic isotretinoin on oral mucosal cells remain poorly understood. This study aimed to investigate the cytological and genotoxic effects of systemic isotretinoin on oral mucosal cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Buccal smear samples were collected from isotretinoin users (<i>n</i> = 20) and controls (<i>n</i> = 20). Cytomorphometric analyses (cell diameter (CD), nuclear diameter (ND), nuclear area (NA), cell area (CA), ND/CD, and NA/CA ratios) and cytological evaluations (nuclear degenerations, binucleation, perinuclear halos) were conducted using Papanicolaou staining. Micronucleus (MN) testing was performed on Feulgen-stained samples.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CD, ND, CA, and NA were significantly higher in the isotretinoin group (<i>p</i> < 0.05), while the ND/CD ratio was reduced (<i>p</i> < 0.05). MN scores and the presence of micronucleated cells (MNed cells) were significantly increased in isotretinoin users (<i>p</i> < 0.05), indicating genotoxic effects. The isotretinoin group showed a lower mean pH (5.8) than controls (6.7) (<i>p</i> < 0.001). No significant differences were linked to isotretinoin duration (less than 6 months (6<) vs. 6 months or more (6≥)) (<i>p</i> > 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Isotretinoin use induces cytological changes, including increased cell and nuclear sizes, and genotoxic effects, as evidenced by elevated MN formation. Monitoring oral mucosal alterations in isotretinoin users may provide insights into potential side effects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 10","pages":"944-952"},"PeriodicalIF":2.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ezhilarasan D, Apoorva VS, and Ashok Vardhan N. Syzygium Cumini Extract Induced Reactive Oxygen Species-Mediated Apoptosis in Human Oral Squamous Carcinoma Cells. Journal of Oral Pathology & Medicine. 48, no. 2 (2019): 115–121.
The morphology images in Figures 1B and 2 of the current online article are incorrect. Figure 1B was mistakenly uploaded during the submission process. Additionally, the second (SC 10 μg) and third (SC 20 μg) images in Figure 2 are identical due to a paneling error. The authors sincerely apologize for these image compilation and paneling mistakes.
{"title":"Corrigendum to “Syzygium Cumini Extract Induced Reactive Oxygen Species-Mediated Apoptosis in Human Oral Squamous Carcinoma Cells”","authors":"","doi":"10.1111/jop.70047","DOIUrl":"10.1111/jop.70047","url":null,"abstract":"<p>Ezhilarasan D, Apoorva VS, and Ashok Vardhan N. Syzygium Cumini Extract Induced Reactive Oxygen Species-Mediated Apoptosis in Human Oral Squamous Carcinoma Cells. <i>Journal of Oral Pathology & Medicine</i>. 48, no. 2 (2019): 115–121.</p><p>The morphology images in Figures 1B and 2 of the current online article are incorrect. Figure 1B was mistakenly uploaded during the submission process. Additionally, the second (SC 10 μg) and third (SC 20 μg) images in Figure 2 are identical due to a paneling error. The authors sincerely apologize for these image compilation and paneling mistakes.</p><p>We apologize for this error.</p>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"916-917"},"PeriodicalIF":2.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human papillomavirus-related cancer inflicts significant morbidity and mortality in adults. Real-life data on the effectiveness of a vaccine are scarce. The purpose of the study was to assess the association between human papillomavirus vaccination and oral and oropharyngeal cancer.
Methods
Queries used de-identified data from patients attending the University of Florida Gainesville Health Center for malignant neoplasm of the oral cavity and pharynx for patients diagnosed between October 2015 and September 2022.
Results
From a hospital population of 1 743 953 patients, 4 131 (0.23%) patients (1228 females and 2903 males) had oropharyngeal cancer. Males were likelier to have oral or oro/oropharyngeal cancer (Odds Ratio = 2.5; p < 0.0001). 56 654 (37 479 females and 19 175 males) were vaccinated, mostly Human papillomavirus 9-VALENT (53%). The vaccine was associated with a reduced odds ratio for oral/oropharyngeal cancer (Odds ratio 0.008, p < 0.0001) that remained low after adjustments for smoking status and alcohol abuse. When stratified by oropharyngeal and oral only, oral pharyngeal had a lower odds ratio with vaccination (0.01, 95%CI 0.00–0.06) compared to the oral cavity (0.03, 95% CI 0.01–0.10). There were also differences in the odds ratio with other risk factors such as gender, race, smoking, and alcohol abuse.
Conclusions
Human papillomavirus vaccination is associated with a reduced odds ratio for oral and oropharyngeal cancer.
{"title":"HPV-Vaccine and Reduced Odds Ratio for Oral and Oropharyngeal Cancer in Both Genders","authors":"J. Katz, H. Gao, A. I. Garcia","doi":"10.1111/jop.70016","DOIUrl":"10.1111/jop.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Human papillomavirus-related cancer inflicts significant morbidity and mortality in adults. Real-life data on the effectiveness of a vaccine are scarce. The purpose of the study was to assess the association between human papillomavirus vaccination and oral and oropharyngeal cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Queries used de-identified data from patients attending the University of Florida Gainesville Health Center for malignant neoplasm of the oral cavity and pharynx for patients diagnosed between October 2015 and September 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From a hospital population of 1 743 953 patients, 4 131 (0.23%) patients (1228 females and 2903 males) had oropharyngeal cancer. Males were likelier to have oral or oro/oropharyngeal cancer (Odds Ratio = 2.5; <i>p</i> < 0.0001). 56 654 (37 479 females and 19 175 males) were vaccinated, mostly Human papillomavirus 9-VALENT (53%). The vaccine was associated with a reduced odds ratio for oral/oropharyngeal cancer (Odds ratio 0.008, <i>p</i> < 0.0001) that remained low after adjustments for smoking status and alcohol abuse. When stratified by oropharyngeal and oral only, oral pharyngeal had a lower odds ratio with vaccination (0.01, 95%CI 0.00–0.06) compared to the oral cavity (0.03, 95% CI 0.01–0.10). There were also differences in the odds ratio with other risk factors such as gender, race, smoking, and alcohol abuse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Human papillomavirus vaccination is associated with a reduced odds ratio for oral and oropharyngeal cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"895-902"},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wan NurHazirah Wan Ahmad Kamil, Munirah Mokhtar, Madia Baizura Baharom, H. M. H. N. Bandara, Mohammad S. Alrashdan, Nicola Cirillo, Mohd Hafiz Arzmi
Background
Candida species and Staphylococcus aureus are nosocomial pathogens associated with immunocompromised individuals, especially oral cancer patients. This study elucidates the effects of mono- and co-culture biofilms of Candida albicans , Candida auris and S. aureus on cell viability and pro-inflammatory cytokine expression in healthy epithelial cells (hTERT TIGKs) and oral cancer (ORL-48) cell lines.
Methods
Mono- and co-culture biofilms of C. albicans , C. auris and S. aureus , developed using static biofilm for 72 h, were collected and filter sterilized (biofilm filtrate). Test cell growth medium (TCGM) was prepared for hTERT TIGKs and ORL-48 by mixing 20% (v/v) biofilm filtrate with 80% serum-free media. The cells were seeded in 96-well plates, and TCGM was added as treatment. The unstimulated media (UM), made of 100% serum-free media, served as control. After 24 h, cell viability was assessed using CCK-8. Interleukin (IL)-6 and IL-8 expression was analysed using enzyme-linked immunosorbent assay (ELISA).
Results
S. aureus consistently decreased cell vitality in co-culture as compared to mono-culture, C. albicans and C. auris in both cell lines. Co-culture of C. auris and S. aureus in cancer cells demonstrated significantly higher IL-6 and IL-8 expression than C. albicans (p < 0.05). Furthermore, co-culturing C. auris or C. albicans with S. aureus increases pro-inflammatory IL-8 expression in oral cancer cell lines compared to mono-cultures of respective Candida.
Conclusion
Co-culturing C. auris or C. albicans with S. aureus reduced cell
{"title":"Mono- and Co-Culture Biofilms of Candida auris or Candida albicans With Staphylococcus aureus Regulate Cell Viability and Pro-Inflammatory Cytokine Expression Differently in Oral Cancer Cell Lines","authors":"Wan NurHazirah Wan Ahmad Kamil, Munirah Mokhtar, Madia Baizura Baharom, H. M. H. N. Bandara, Mohammad S. Alrashdan, Nicola Cirillo, Mohd Hafiz Arzmi","doi":"10.1111/jop.70043","DOIUrl":"10.1111/jop.70043","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>\u0000 <i>Candida</i> species and \u0000 <i>Staphylococcus aureus</i>\u0000 are nosocomial pathogens associated with immunocompromised individuals, especially oral cancer patients. This study elucidates the effects of mono- and co-culture biofilms of \u0000 <i>Candida albicans</i>\u0000 , <i>Candida auris</i> and \u0000 <i>S. aureus</i>\u0000 on cell viability and pro-inflammatory cytokine expression in healthy epithelial cells (hTERT TIGKs) and oral cancer (ORL-48) cell lines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Mono- and co-culture biofilms of \u0000 <i>C. albicans</i>\u0000 , \u0000 <i>C. auris</i>\u0000 and \u0000 <i>S. aureus</i>\u0000 , developed using static biofilm for 72 h, were collected and filter sterilized (biofilm filtrate). Test cell growth medium (TCGM) was prepared for hTERT TIGKs and ORL-48 by mixing 20% (v/v) biofilm filtrate with 80% serum-free media. The cells were seeded in 96-well plates, and TCGM was added as treatment. The unstimulated media (UM), made of 100% serum-free media, served as control. After 24 h, cell viability was assessed using CCK-8. Interleukin (IL)-6 and IL-8 expression was analysed using enzyme-linked immunosorbent assay (ELISA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>\u0000 \u0000 <i>S. aureus</i>\u0000 consistently decreased cell vitality in co-culture as compared to mono-culture, \u0000 <i>C. albicans</i>\u0000 and \u0000 <i>C. auris</i>\u0000 in both cell lines. Co-culture of \u0000 <i>C. auris</i>\u0000 and \u0000 <i>S. aureus</i>\u0000 in cancer cells demonstrated significantly higher IL-6 and IL-8 expression than \u0000 <i>C. albicans</i>\u0000 (<i>p</i> < 0.05). Furthermore, co-culturing \u0000 <i>C. auris</i>\u0000 or \u0000 <i>C. albicans</i>\u0000 with \u0000 <i>S. aureus</i>\u0000 increases pro-inflammatory IL-8 expression in oral cancer cell lines compared to mono-cultures of respective <i>Candida</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Co-culturing \u0000 <i>C. auris</i>\u0000 or \u0000 <i>C. albicans</i>\u0000 with \u0000 <i>S. aureus</i>\u0000 reduced cell","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"909-915"},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Everton Freitas de Morais, Lívia Maris Ribeiro Paranaiba Dias, Ana Lúcia Carrinho Ayroza Rangel, Ricardo D. Coletta
Background
Prognostic stratification to predict patient outcomes and guide treatment decisions is urgently needed to improve clinical management of oral squamous cell carcinoma (OSCC). This study evaluated the prognostic performance of a novel histopathologic risk model that integrates modifications to the worst pattern of invasion (WPOI) system and tumor budding (TB) classification for OSCC, focusing on its effectiveness in predicting recurrence and survival.
Methods
In a retrospective study of 193 OSCC cases, the modifications incorporated to the WPOI and TB were initially compared to conventional assessments. Next, the effectiveness of the novel histopathologic risk model was assessed. Univariate and multivariate survival analyses were performed using Cox proportional hazards models. The performance of the classifiers was evaluated by applying the receiver operating characteristic (ROC) analysis, calculating the area under the curve (AUC).
Results
Classical WPOI was significantly and independently associated with shortened cancer-specific survival (HR = 2.0, 95% CI = 1.26–3.25, p = 0.003); whereas classical TB was associated with poor disease-free survival (HR = 2.17, 95% CI = 1.25–3.74, p = 0.005). In contrast, the modified WPOI and TB showed no significant associations with patient outcomes. The novel histopathologic risk model, which categorized 68.4% of cases as intermediate risk, showed limited ability to predict OSCC outcomes.
Conclusions
The findings of this study show the superior prognostic value of the classical WPOI and TB over their modified counterparts; the potential of the novel histopathologic risk was not validated in this cohort including OSCCs at all clinical stages.
背景：迫切需要预后分层来预测患者预后并指导治疗决策，以改善口腔鳞状细胞癌（OSCC）的临床管理。本研究评估了一种新的组织病理学风险模型的预后表现，该模型整合了对OSCC最坏侵袭模式（WPOI）系统和肿瘤萌芽（TB）分类的修改，重点关注其预测复发和生存的有效性。方法：在一项对193例OSCC病例的回顾性研究中，将WPOI和TB的修改与常规评估进行了初步比较。接下来，评估了新型组织病理学风险模型的有效性。采用Cox比例风险模型进行单因素和多因素生存分析。通过应用受试者工作特征（ROC）分析来评估分类器的性能，计算曲线下面积（AUC）。结果：经典WPOI与缩短的癌症特异性生存期（HR = 2.0, 95% CI = 1.26-3.25, p = 0.003）显著且独立相关；而经典结核病与较差的无病生存率相关（HR = 2.17, 95% CI = 1.25-3.74, p = 0.005）。相比之下，改良后的WPOI和TB与患者预后无显著关联。新的组织病理学风险模型将68.4%的病例归类为中度风险，但预测OSCC预后的能力有限。结论：本研究结果显示经典WPOI和TB的预后价值优于其改良对照；在包括所有临床阶段的oscc在内的该队列中，未验证新型组织病理学风险的可能性。
{"title":"Prognostic Significance of a Novel Histopathologic Risk Model Incorporating Modifications to the Worst Pattern of Invasion and Tumor Budding for Oral Squamous Cell Carcinoma","authors":"Everton Freitas de Morais, Lívia Maris Ribeiro Paranaiba Dias, Ana Lúcia Carrinho Ayroza Rangel, Ricardo D. Coletta","doi":"10.1111/jop.70046","DOIUrl":"10.1111/jop.70046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Prognostic stratification to predict patient outcomes and guide treatment decisions is urgently needed to improve clinical management of oral squamous cell carcinoma (OSCC). This study evaluated the prognostic performance of a novel histopathologic risk model that integrates modifications to the worst pattern of invasion (WPOI) system and tumor budding (TB) classification for OSCC, focusing on its effectiveness in predicting recurrence and survival.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a retrospective study of 193 OSCC cases, the modifications incorporated to the WPOI and TB were initially compared to conventional assessments. Next, the effectiveness of the novel histopathologic risk model was assessed. Univariate and multivariate survival analyses were performed using Cox proportional hazards models. The performance of the classifiers was evaluated by applying the receiver operating characteristic (ROC) analysis, calculating the area under the curve (AUC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Classical WPOI was significantly and independently associated with shortened cancer-specific survival (HR = 2.0, 95% CI = 1.26–3.25, <i>p</i> = 0.003); whereas classical TB was associated with poor disease-free survival (HR = 2.17, 95% CI = 1.25–3.74, <i>p</i> = 0.005). In contrast, the modified WPOI and TB showed no significant associations with patient outcomes. The novel histopathologic risk model, which categorized 68.4% of cases as intermediate risk, showed limited ability to predict OSCC outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings of this study show the superior prognostic value of the classical WPOI and TB over their modified counterparts; the potential of the novel histopathologic risk was not validated in this cohort including OSCCs at all clinical stages.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"903-908"},"PeriodicalIF":2.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jop.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bernardo da Fonseca Orcina, Ezequiel Azevedo Schemmfelnnig, Rebeka Camille Carvalho Chamon, Douglas Magno Guimarães, Maria Sueli da Silva Kataoka, Sérgio de Melo Alves Júnior, Sandra Beatriz Chaves Tarquinio, Ana Carolina Uchoa Vasconcelos, Ana Paula Neutzling Gomes, João de Jesus Viana Pinheiro, Adriana Etges
Background
Central giant cell granuloma (CGCG) is a benign and locally confined osteolytic lesion that occasionally exhibits aggressive behavior, while the peripheral giant cell granuloma (PGCG) is a reactive lesion with localized proliferation. Both lesions present similar histological characteristics.
Objective
To compare the immunoexpression of the main invadopodia-related proteins in CGCG and PGCG in the jaws.
Methods
30 CGCG and 12 PGCG biopsied at the oral and maxillofacial pathology departments of three universities were evaluated. The expression of cortactin, MT1-MMP, TKS4, and TKS5, in spindle-shaped and polygonal mononuclear cells (SPMC) and multinucleated giant cells (MGC) was observed through immunohistochemistry, and the labeled areas were semi-automatically detected by an image processing software equipped with an efficient color detection plugin. The percentages of labeled areas in MGC and SPMC for both lesions were statistically compared at a significance level of p < 0.05.
Results
The expressions of all evaluated proteins in MGC were significantly higher for CGCG than PGCG (p < 0.05). Regarding SPMC, only the expressions of cortactin and TKS5 were significantly higher expressed in CGCG than in PGCG (p < 0.05).
Conclusion
The significantly higher expressions of cortactin (MGC, SPMC), TKS4 (MGC), TKS5 (MGC, SPMC), and MT1-MMP (MGC) in CGCG may partially explain its greater invasiveness/aggressiveness.
{"title":"An Investigation of the Differences in Cortactin, MT1-MMP, TKS4, and TKS5 Immunoexpression Between Central and Peripheral Giant Cell Granulomas","authors":"Bernardo da Fonseca Orcina, Ezequiel Azevedo Schemmfelnnig, Rebeka Camille Carvalho Chamon, Douglas Magno Guimarães, Maria Sueli da Silva Kataoka, Sérgio de Melo Alves Júnior, Sandra Beatriz Chaves Tarquinio, Ana Carolina Uchoa Vasconcelos, Ana Paula Neutzling Gomes, João de Jesus Viana Pinheiro, Adriana Etges","doi":"10.1111/jop.70040","DOIUrl":"10.1111/jop.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Central giant cell granuloma (CGCG) is a benign and locally confined osteolytic lesion that occasionally exhibits aggressive behavior, while the peripheral giant cell granuloma (PGCG) is a reactive lesion with localized proliferation. Both lesions present similar histological characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the immunoexpression of the main invadopodia-related proteins in CGCG and PGCG in the jaws.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>30 CGCG and 12 PGCG biopsied at the oral and maxillofacial pathology departments of three universities were evaluated. The expression of cortactin, MT1-MMP, TKS4, and TKS5, in spindle-shaped and polygonal mononuclear cells (SPMC) and multinucleated giant cells (MGC) was observed through immunohistochemistry, and the labeled areas were semi-automatically detected by an image processing software equipped with an efficient color detection plugin. The percentages of labeled areas in MGC and SPMC for both lesions were statistically compared at a significance level of <i>p</i> < 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The expressions of all evaluated proteins in MGC were significantly higher for CGCG than PGCG (<i>p</i> < 0.05). Regarding SPMC, only the expressions of cortactin and TKS5 were significantly higher expressed in CGCG than in PGCG (<i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The significantly higher expressions of cortactin (MGC, SPMC), TKS4 (MGC), TKS5 (MGC, SPMC), and MT1-MMP (MGC) in CGCG may partially explain its greater invasiveness/aggressiveness.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"884-894"},"PeriodicalIF":2.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessandra Laís Pinho Valente Pires, Adriana Mendonça da Silva, Murilo Cruz, Ynara Bosco de Oliveira Lima-Arsati, Franco Arsati, Rodrigo Tripodi Calumby, Jean Nunes dos Santos, Gabriela Botelho Martins, Valéria Souza Freitas
Objective
To estimate the network structure of 21 symptoms of anxiety and depression in individuals diagnosed with oral lichen planus (OLP) and compare it with salivary biomarkers, cortisol and alpha-amylase.
Materials and Methods
A case–control study was conducted with 21 OLP cases and 21 controls matched by sex and age. Beck Anxiety and Depression Inventories were administered, and salivary cortisol and alpha-amylase levels were determined. Descriptive analysis used the Mann–Whitney U test to compare participants' responses and the Benjamini-Hochberg Method to control the False Discovery Rate (FDR). Network analysis was performed using regularized partial correlation network models.
Results
A significant association was found between anxiety (p = 0.001) and depression (p = 0.004) scores and OLP. The “shaky/unsteady” symptom was most central in the anxiety network for OLP patients, while “feelings of punishment” and “self-criticism” were central in the depression network. Weak correlations were observed between cortisol and alpha-amylase in anxiety and depressive symptoms. Cortisol awekening response (CAR) had a negative correlation with alpha-amylase awakening response (AAR) (−0.54), as like AAR and Faint/lightheaded (−0.57) in anxiety network. Anxiety network structures did not differ between groups (p = 0.18), but the depression network was more connected in controls than in OLP cases (overall strength 69.29 vs. 27.35, p < 0.000).
Conclusion
This study reveals the distinct network structures of anxiety and depression symptoms in OLP patients, highlighting a new methodological approach to exploring symptom configurations. When exploring the relationship with cortisol and alpha-amylase, weak relationships were found between them. The findings may prompt further network studies involving biomarkers and their interaction with anxiety and depression.
{"title":"Network Analysis of Anxiety and Depression Symptoms in Individuals With Oral Lichen Planus and Evaluation of Salivary Biomarkers: A New Approach","authors":"Alessandra Laís Pinho Valente Pires, Adriana Mendonça da Silva, Murilo Cruz, Ynara Bosco de Oliveira Lima-Arsati, Franco Arsati, Rodrigo Tripodi Calumby, Jean Nunes dos Santos, Gabriela Botelho Martins, Valéria Souza Freitas","doi":"10.1111/jop.70038","DOIUrl":"10.1111/jop.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To estimate the network structure of 21 symptoms of anxiety and depression in individuals diagnosed with oral lichen planus (OLP) and compare it with salivary biomarkers, cortisol and alpha-amylase.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A case–control study was conducted with 21 OLP cases and 21 controls matched by sex and age. Beck Anxiety and Depression Inventories were administered, and salivary cortisol and alpha-amylase levels were determined. Descriptive analysis used the Mann–Whitney U test to compare participants' responses and the Benjamini-Hochberg Method to control the False Discovery Rate (FDR). Network analysis was performed using regularized partial correlation network models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant association was found between anxiety (<i>p</i> = 0.001) and depression (<i>p</i> = 0.004) scores and OLP. The “shaky/unsteady” symptom was most central in the anxiety network for OLP patients, while “feelings of punishment” and “self-criticism” were central in the depression network. Weak correlations were observed between cortisol and alpha-amylase in anxiety and depressive symptoms. Cortisol awekening response (CAR) had a negative correlation with alpha-amylase awakening response (AAR) (−0.54), as like AAR and Faint/lightheaded (−0.57) in anxiety network. Anxiety network structures did not differ between groups (<i>p</i> = 0.18), but the depression network was more connected in controls than in OLP cases (overall strength 69.29 vs. 27.35, <i>p</i> < 0.000).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study reveals the distinct network structures of anxiety and depression symptoms in OLP patients, highlighting a new methodological approach to exploring symptom configurations. When exploring the relationship with cortisol and alpha-amylase, weak relationships were found between them. The findings may prompt further network studies involving biomarkers and their interaction with anxiety and depression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"872-883"},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MiRNAs have essential research value and broad clinical application prospects in oral cancer.
Aims
We provided a comprehensive understanding of trends, current features, and priorities in the field of miRNA and oral cancer research based on bibliometrics.
Materials and Methods
Reference records were obtained from the Web of Science core collection and analyzed using CiteSpace 6.2.4, VOSviewer 1.6.20, and GraphPad Prism 8.
Results
Results showed that between 2008 and 2024, a total of 1149 publications in the database were retrieved to study the role of miRNAs in oral cancer. The annual number of publications showed an increasing trend from year to year, peaking in 2021. Among them, China (470 articles), China Medical University (37 articles), and the journal Oral Oncology demonstrated the highest research productivity in terms of countries (regions), institutions, and journals.
Discussion
Keywords and cited literature indicate that the current research focus is mainly on microenvironmentally- derived miRNAs as potential diagnostic and therapeutic targets for oral cancer. Recent studies have gradually focused on the experimental study of drug delivery systems of miRNAs in treating oral cancer, which may become one of the important research directions in the future.
Conclusions
Thus, by searching the literature in the field of miRNAs and oral cancer from the Web of Science core collection and performing bibliometric analysis, the development of research and research hotspots in the last two decades was mapped out. This will provide valuable references and guidelines for relevant scholars and researchers to explore the direction in future research endeavors.
背景：MiRNAs在口腔癌中具有重要的研究价值和广阔的临床应用前景。目的：我们基于文献计量学对miRNA和口腔癌研究领域的趋势、当前特征和重点进行了全面的了解。材料和方法：从Web of Science核心文集中获取文献记录，使用CiteSpace 6.2.4、VOSviewer 1.6.20和GraphPad Prism 8进行分析。结果：结果显示，2008年至2024年间，共检索数据库中1149篇研究miRNAs在口腔癌中的作用的出版物。年发表数呈逐年增加趋势，在2021年达到顶峰。其中，中国（470篇）、中国医科大学（37篇）和《口腔肿瘤学》杂志在国家（地区）、机构和期刊上的研究生产力最高。讨论：关键词和引用文献表明，目前的研究重点主要是微环境来源的mirna作为口腔癌的潜在诊断和治疗靶点。近年来的研究逐渐集中在mirna药物传递系统治疗口腔癌的实验研究上，这可能成为未来重要的研究方向之一。由此，通过检索Web of Science核心馆藏中miRNAs与口腔癌领域的文献，并进行文献计量分析，勾勒出近二十年的研究发展和研究热点。这将为相关学者和研究人员探索未来的研究方向提供有价值的参考和指导。
{"title":"Bibliometrics-Based Mapping of Research on the Role of miRNAs in Oral Cancer","authors":"Yujing Wang, Rujie Shi, Baisheng Wang, Kun Li","doi":"10.1111/jop.70037","DOIUrl":"10.1111/jop.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>MiRNAs have essential research value and broad clinical application prospects in oral cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>We provided a comprehensive understanding of trends, current features, and priorities in the field of miRNA and oral cancer research based on bibliometrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Reference records were obtained from the Web of Science core collection and analyzed using CiteSpace 6.2.4, VOSviewer 1.6.20, and GraphPad Prism 8.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results showed that between 2008 and 2024, a total of 1149 publications in the database were retrieved to study the role of miRNAs in oral cancer. The annual number of publications showed an increasing trend from year to year, peaking in 2021. Among them, China (470 articles), China Medical University (37 articles), and the journal <i>Oral Oncology</i> demonstrated the highest research productivity in terms of countries (regions), institutions, and journals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Keywords and cited literature indicate that the current research focus is mainly on microenvironmentally- derived miRNAs as potential diagnostic and therapeutic targets for oral cancer. Recent studies have gradually focused on the experimental study of drug delivery systems of miRNAs in treating oral cancer, which may become one of the important research directions in the future.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Thus, by searching the literature in the field of miRNAs and oral cancer from the Web of Science core collection and performing bibliometric analysis, the development of research and research hotspots in the last two decades was mapped out. This will provide valuable references and guidelines for relevant scholars and researchers to explore the direction in future research endeavors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16588,"journal":{"name":"Journal of Oral Pathology & Medicine","volume":"54 9","pages":"777-789"},"PeriodicalIF":2.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessia Riente, Alessio Abeltino, Cassandra Serantoni, Michele Maria De Giulio, Giada Bianchetti, Mariaconsiglia Santantonio, Giulio Cesare Passali, Stefano Capezzone, Rosita Esposito, Marco De Spirito, Giuseppe Maulucci
<div> <section> <h3> Background</h3> <p>Trigeminal neuralgia (TN) is a rare and debilitating condition characterized by severe, episodic facial pain, with an incidence of about five individuals per 100 000 annually, predominantly affecting women aged 50–70 years. TN is often difficult to diagnose; leading to underestimation or misdiagnosis and prolonged patient suffering.</p> </section> <section> <h3> Objective</h3> <p>This study aimed to assess masticatory dysfunction in individuals with and without TN using an electromyographic device (“Chewing”) and evaluate its potential to quantify pain-related dysfunction and inform treatment approaches.</p> </section> <section> <h3> Methods</h3> <p>This observational study assessed masticatory dysfunction in TN patients and healthy controls using “Chewing” device. Masticatory behavior was monitored with apple and carrot as test foods, and parameters such as chewing time, number of chews, and chewing force were recorded. Participants were clustered based on masticatory patterns using an unsupervised learning approach.</p> </section> <section> <h3> Results</h3> <p>Two distinct clusters of masticatory behavior emerged from the analysis. Cluster 1, representing 27.5% of TN1 patients, was characterized by prolonged chewing duration, a greater number of chewing cycles, and reduced chewing force compared to Cluster 0. Specifically, during apple mastication, Cluster 1 showed a 24% increase in chewing time (<i>p</i> = 0.02), a twofold increase in the number of chews (<i>p</i> < 0.001), and a 50% reduction in chewing force (<i>p</i> < 0.001). When chewing carrots, the number of chews increased by 57% (<i>p</i> < 0.001), while chewing force decreased by 64% (<i>p</i> < 0.001). Chewing frequency was also significantly higher in Cluster 1 for both food types (<i>p</i> < 0.001). Furthermore, a higher prevalence of TN1 patients was found in Cluster 1 compared to Cluster 0 (χ<sup>2</sup> = 4.53, <i>p</i> = 0.05), suggesting an association between altered masticatory behavior and trigeminal neuralgia. Nonetheless, the presence of some TN1 patients in Cluster 0 indicates that masticatory function may remain intact in certain individuals, possibly due to milder pain symptoms or the development of compensatory coping strategies.</p> </section> <section> <h3> Conclusions</h3> <p>“Chewing” device successfully quantified and differentiated masticatory patterns, providing valuable insights into functional adaptations
背景：三叉神经痛（TN）是一种罕见的衰弱性疾病，其特征是严重的、发作性面部疼痛，每年每10万人中约有5人发病，主要影响50-70岁的女性。TN通常难以诊断；导致低估或误诊，延长患者的痛苦。目的：本研究旨在使用肌电图装置（“咀嚼”）评估有和没有TN的个体的咀嚼功能障碍，并评估其量化疼痛相关功能障碍和告知治疗方法的潜力。方法：本观察性研究使用“咀嚼”装置评估TN患者和健康对照者的咀嚼功能障碍。以苹果、胡萝卜为试验食物监测咀嚼行为，记录咀嚼时间、咀嚼次数、咀嚼力度等参数。使用无监督学习方法根据咀嚼模式对参与者进行聚类。结果：从分析中出现了两个不同的咀嚼行为集群。第1组占TN1患者的27.5%，与第0组相比，其特征是咀嚼时间延长，咀嚼循环次数增加，咀嚼力降低。具体而言，在咀嚼苹果时，集群1咀嚼时间增加24% (p = 0.02)，咀嚼次数增加两倍（p 2 = 4.53, p = 0.05），表明咀嚼行为改变与三叉神经痛之间存在关联。然而，在第0组中出现的一些TN1患者表明，某些个体的咀嚼功能可能保持完整，这可能是由于较轻的疼痛症状或代偿性应对策略的发展。结论：“咀嚼”装置成功地量化和区分了咀嚼模式，为功能适应提供了有价值的见解。根据咀嚼行为对TN患者进行亚组可以指导个性化治疗策略，改善患者预后。
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