R. Takeuchi, K. Arikawa, T. Uchiyama, E. Aida, Michiko Takefuta, K. Nakakuki, T. Utsunomiya
{"title":"Amlodipine Inhibits the G 1 /S Cell Cycle Transition Induced by Basic Fibroblast Growth Factor in Human Gingival Fibroblasts","authors":"R. Takeuchi, K. Arikawa, T. Uchiyama, E. Aida, Michiko Takefuta, K. Nakakuki, T. Utsunomiya","doi":"10.11223/JARDE.11.141","DOIUrl":"https://doi.org/10.11223/JARDE.11.141","url":null,"abstract":"","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"139 1","pages":"141-147"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79921005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Miyamae, K. Kaneda, Y. Inamura, Mayumi Shiomi, Shizuka Koshinuma, Y. Momota, M. Vincent
{"title":"Sevoflurane Increases p38 Mitogen Activated Protein Kinase Phosphorylation During Ischemia, but its Cardioprotective Effect is not Blocked by SB 203580","authors":"M. Miyamae, K. Kaneda, Y. Inamura, Mayumi Shiomi, Shizuka Koshinuma, Y. Momota, M. Vincent","doi":"10.11223/JARDE.11.17","DOIUrl":"https://doi.org/10.11223/JARDE.11.17","url":null,"abstract":"","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"19 1","pages":"17-28"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78744677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Criteria for Choice of Dental Treatment: A Follow-up Survey of Foreign Residents","authors":"J. Fujita, E. Schoenbrunn, Bernard Macmugen","doi":"10.11223/JARDE.11.172","DOIUrl":"https://doi.org/10.11223/JARDE.11.172","url":null,"abstract":"","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"80 1","pages":"172-179"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74109906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Use of Porous Composite Uncalcined Hydroxyapatite / poly-DL-lactide for Vertical Ridge Augmentation","authors":"N. Akino, N. Tachikawa, M. Munakata, S. Kasugai","doi":"10.11223/JARDE.10.123","DOIUrl":"https://doi.org/10.11223/JARDE.10.123","url":null,"abstract":"","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"10 1","pages":"123-130"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82150577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kazuhiro Sato, Tomohiro Umemura, Tarou Tamura, Y. Kusaka, Kohji Aoyama, A. Ueda, Kohichi Harada, K. Minamoto, T. Otsuki, Kunihiko Yamashita, Masahiro Haitsuka, T. Takeshita, Eiji Shibata, K. Dobashi, S. Kameo, M. Miyagawa, M. Kaniwa, Takahiko Yoshida, T. Fukushima, K. Yuta
Department of Environmental Health, School of Medicine, University of Fukui, Fukui, Japan, Department of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, Department of Environmental Health, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Kumamoto University, Graduate School of Health Sciences, School of Health Sciences, Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan, Daicel Corporation, Ltd., Himeji, Japan, Department of Public Health, School of Medicine, Wakayama Medical University, Wakayama, Japan, Department of Hygiene, Aichi Medical University, Nagakute, Japan, School of Health Sciences, Faculty of Medicine, Gunma University, Maebashi, Japan, Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Japan, National Institute of Occupational Safety and Health, Kawasaki, Japan, Division of Medical Devices, National Institute of Health Sciences, Tokyo, Japan, Deaprtment of Health Science, School of Medicine, Asahikawa Medical University, Asahikawa, Japan, Department of Hygiene and Preventive Medicine, School of Medicine, Fukushima Medical University, Fukushima, JAPAN, Fujitsu Limited, Tokyo, Japan, In Silico Data Ltd. , Narashino, Japan
{"title":"Skin Sensitization Study by a New Qualitative Structure-toxicity Relationships (QSTR) Approach: K-step Yard Sampling (KY) Methods","authors":"Kazuhiro Sato, Tomohiro Umemura, Tarou Tamura, Y. Kusaka, Kohji Aoyama, A. Ueda, Kohichi Harada, K. Minamoto, T. Otsuki, Kunihiko Yamashita, Masahiro Haitsuka, T. Takeshita, Eiji Shibata, K. Dobashi, S. Kameo, M. Miyagawa, M. Kaniwa, Takahiko Yoshida, T. Fukushima, K. Yuta","doi":"10.11223/JARDE.9.167","DOIUrl":"https://doi.org/10.11223/JARDE.9.167","url":null,"abstract":"Department of Environmental Health, School of Medicine, University of Fukui, Fukui, Japan, Department of Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, Department of Environmental Health, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Kumamoto University, Graduate School of Health Sciences, School of Health Sciences, Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan, Daicel Corporation, Ltd., Himeji, Japan, Department of Public Health, School of Medicine, Wakayama Medical University, Wakayama, Japan, Department of Hygiene, Aichi Medical University, Nagakute, Japan, School of Health Sciences, Faculty of Medicine, Gunma University, Maebashi, Japan, Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Japan, National Institute of Occupational Safety and Health, Kawasaki, Japan, Division of Medical Devices, National Institute of Health Sciences, Tokyo, Japan, Deaprtment of Health Science, School of Medicine, Asahikawa Medical University, Asahikawa, Japan, Department of Hygiene and Preventive Medicine, School of Medicine, Fukushima Medical University, Fukushima, JAPAN, Fujitsu Limited, Tokyo, Japan, In Silico Data Ltd. , Narashino, Japan","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"37 1","pages":"167-173"},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81107720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Toshimi Iizuka, Takahiko Kagaya, K. Atsuda, Y. Yoshiyama
152 INTRODUCTION The isosorbide dinitrate or mononitrate are used chiefly to treat angina pectoris, and used as the osmotic diuretics in Japan. Additionally, it is used as a treatment of the intracranial hypertension, the ocular hypertension, and Meniere's disease. ISOBIDE was approved and put on the market in Japan in 1968. ISOBIDE is raising plasma osmolality and shows a brain pressure descent action, an intraocular pressure descent action, an inner lymph pressure descent action of an ear, and a diuretic effect. Moreover, a brain tumor patient may be administered for the purpose of brain pressure descent. However, the taste of ISOBIDE is unpalatable in the one that sweetness, acidity, and bitterness existed together. Generally, a bad taste drug may resist taking medicine, the possibility that the effect of the drug therapy is not achieved is thought, and there is a possibility that a satisfactory therapeutic effect is not obtained. In a package insert, it is important to consider the taste to complete the drug therapy though the method to take by the dilution with water is adopted to secure the adherence of ISOBIDE. In Evaluation of the Taste of Value Added Generic Drugs by a Taste Sensor
{"title":"Evaluation of the Taste of Value Added Generic Drugs by a Taste Sensor","authors":"Toshimi Iizuka, Takahiko Kagaya, K. Atsuda, Y. Yoshiyama","doi":"10.11223/JARDE.9.152","DOIUrl":"https://doi.org/10.11223/JARDE.9.152","url":null,"abstract":"152 INTRODUCTION The isosorbide dinitrate or mononitrate are used chiefly to treat angina pectoris, and used as the osmotic diuretics in Japan. Additionally, it is used as a treatment of the intracranial hypertension, the ocular hypertension, and Meniere's disease. ISOBIDE was approved and put on the market in Japan in 1968. ISOBIDE is raising plasma osmolality and shows a brain pressure descent action, an intraocular pressure descent action, an inner lymph pressure descent action of an ear, and a diuretic effect. Moreover, a brain tumor patient may be administered for the purpose of brain pressure descent. However, the taste of ISOBIDE is unpalatable in the one that sweetness, acidity, and bitterness existed together. Generally, a bad taste drug may resist taking medicine, the possibility that the effect of the drug therapy is not achieved is thought, and there is a possibility that a satisfactory therapeutic effect is not obtained. In a package insert, it is important to consider the taste to complete the drug therapy though the method to take by the dilution with water is adopted to secure the adherence of ISOBIDE. In Evaluation of the Taste of Value Added Generic Drugs by a Taste Sensor","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"15 1","pages":"152-158"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73657764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In Vitro Embryotoxicity Testing of Biomaterials by Improvement of Embryonic Stem Cell Test (EST)","authors":"K. Imai, Kazuaki Nakamura, A. Tanoue","doi":"10.11223/JARDE.10.48","DOIUrl":"https://doi.org/10.11223/JARDE.10.48","url":null,"abstract":"","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"18 1","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89682580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natsuki Yasui, Y. Taguchi, A. Tanaka, M. Ueda, M. Umeda
126 INTRODUCTION Emdogain (EMD) extracted from the tooth germ of juvenile swine is a material that can generate acellular cementum and facilitate periodontal regeneration in patients with periodontitis featuring marked alveolar bone resorption. EMD has been clinically used as Emdogain gel for more than a decade to produce marked regenerative effects . In addition, the molecular mechanisms behind the action of EMD on the structural cells of periodontal tissue have been comprehensively investigated for about a decade to substantiate its regenerative effects. Periodontal regenerative therapy with EMD is being established. The therapy is recognized as an advanced medical technology in Japan. However, EMD is a biological material extracted from the tooth germ of juvenile swine. Thus, patients reject EMD treatment because of concerns about unknown pathogens. Currently, many patients still choose guided tissue regeneration (GTR) with a blocking membrane, recommended for periodontal regenerative therapy in Japan . Thus, synthetic peptides should be developed. To make the best use of clinical data obtained over approximately a decade concerning the regenerative effects and postoperative stability of EMD, EMD-derived synthetic peptides should be developed. Traditional Biological Effects of Emdogain-derived Oligopeptides on Rat Bone Marrow Cells in Vitro
{"title":"Biological Effects of Emdogain ® -derived Oligopeptides on Rat Bone Marrow Cells in Vitro","authors":"Natsuki Yasui, Y. Taguchi, A. Tanaka, M. Ueda, M. Umeda","doi":"10.11223/JARDE.9.126","DOIUrl":"https://doi.org/10.11223/JARDE.9.126","url":null,"abstract":"126 INTRODUCTION Emdogain (EMD) extracted from the tooth germ of juvenile swine is a material that can generate acellular cementum and facilitate periodontal regeneration in patients with periodontitis featuring marked alveolar bone resorption. EMD has been clinically used as Emdogain gel for more than a decade to produce marked regenerative effects . In addition, the molecular mechanisms behind the action of EMD on the structural cells of periodontal tissue have been comprehensively investigated for about a decade to substantiate its regenerative effects. Periodontal regenerative therapy with EMD is being established. The therapy is recognized as an advanced medical technology in Japan. However, EMD is a biological material extracted from the tooth germ of juvenile swine. Thus, patients reject EMD treatment because of concerns about unknown pathogens. Currently, many patients still choose guided tissue regeneration (GTR) with a blocking membrane, recommended for periodontal regenerative therapy in Japan . Thus, synthetic peptides should be developed. To make the best use of clinical data obtained over approximately a decade concerning the regenerative effects and postoperative stability of EMD, EMD-derived synthetic peptides should be developed. Traditional Biological Effects of Emdogain-derived Oligopeptides on Rat Bone Marrow Cells in Vitro","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"C-18 1","pages":"126-135"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85047648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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