Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.059
Zervos M, Lepetsos P, Zafeiris C
The main function of osteoblasts is new bone production during the process of skeletal growth and bone remodelling. During bone remodelling, osteoblasts interact directly with other osteoblasts and other bone cells, such as osteoclasts, osteocytes, and mesenchymal stem cells, through complex cellular mechanisms. With the contribution of these mechanisms, osteoblasts and osteoclasts are responsible for the preservation of a balance between bone production and bone resorption. Bone metastatic disease is a frequent and unpleasant event in advanced stages of malign tumors. When the tumor cells spread to the bone microenvironment, they use the specific cellular mechanisms, disrupting the homeostasis of the bones. The cross-talk among cancer cells and bone tissue cells is crucial in the maintenance of the metastatic process, including the initial survival and seeding of disseminated tumor cells, activation of inactive micro metastatic lesions, and outspread of osteoblastic or osteolytic metastases. The aim of this review is to describe the role of osteoblasts in bone metastatic disease.
{"title":"The Role of Osteoblasts in Bone Metastatic Disease","authors":"Zervos M, Lepetsos P, Zafeiris C","doi":"10.51737/2766-4813.2022.059","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.059","url":null,"abstract":"The main function of osteoblasts is new bone production during the process of skeletal growth and bone remodelling. During bone remodelling, osteoblasts interact directly with other osteoblasts and other bone cells, such as osteoclasts, osteocytes, and mesenchymal stem cells, through complex cellular mechanisms. With the contribution of these mechanisms, osteoblasts and osteoclasts are responsible for the preservation of a balance between bone production and bone resorption. Bone metastatic disease is a frequent and unpleasant event in advanced stages of malign tumors. When the tumor cells spread to the bone microenvironment, they use the specific cellular mechanisms, disrupting the homeostasis of the bones. The cross-talk among cancer cells and bone tissue cells is crucial in the maintenance of the metastatic process, including the initial survival and seeding of disseminated tumor cells, activation of inactive micro metastatic lesions, and outspread of osteoblastic or osteolytic metastases. The aim of this review is to describe the role of osteoblasts in bone metastatic disease.","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121412164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.050
M. K, B. H, Hayashi K, Dohi A, K. A
Recent pharmacological topic for diabetes includes clinical application of Glucagon-like peptide 1 receptor agonists (GLP-1 RAs). Among them, oral semaglutide (Rybelsus) has been developed as the first oral form of GLP-1RA by useful application of sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). Semaglutide concentration in the blood was compared when fasting time period after Rybelsus administration would be 15, 30, 60 and 120 minutes. As a result, the concentration ratio after 4 hours was 1.00, 1.67, 2.60 and 3.06, respectively. Authors have experienced a diabetic case of remarkable efficacy as HbA1c -1.4% and weight -5kg, who kept 3-4 hours fasting after Rybelsus intake.
{"title":"Longer Fasting After Rybelsus Administration Contributes Higher Efficacy","authors":"M. K, B. H, Hayashi K, Dohi A, K. A","doi":"10.51737/2766-4813.2022.050","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.050","url":null,"abstract":"Recent pharmacological topic for diabetes includes clinical application of Glucagon-like peptide 1 receptor agonists (GLP-1 RAs). Among them, oral semaglutide (Rybelsus) has been developed as the first oral form of GLP-1RA by useful application of sodium N-(8-[2-hydroxybenzoyl] amino) caprylate (SNAC). Semaglutide concentration in the blood was compared when fasting time period after Rybelsus administration would be 15, 30, 60 and 120 minutes. As a result, the concentration ratio after 4 hours was 1.00, 1.67, 2.60 and 3.06, respectively. Authors have experienced a diabetic case of remarkable efficacy as HbA1c -1.4% and weight -5kg, who kept 3-4 hours fasting after Rybelsus intake.","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125296234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2023.072
Shala A, Bojaxhiu Huçaj B
{"title":"The Importance of Family Cohesion in the Mental Health Well-Being of People Affected By Cancer in Coping with Adversity","authors":"Shala A, Bojaxhiu Huçaj B","doi":"10.51737/2766-4813.2023.072","DOIUrl":"https://doi.org/10.51737/2766-4813.2023.072","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129660377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2023.082
M. S, U. A, H. S.
{"title":"Recurrent Planter Fasciitis as First Extraintestinal Manifestation of Inflammatory Bowel Disease [Crohn's Disease]","authors":"M. S, U. A, H. S.","doi":"10.51737/2766-4813.2023.082","DOIUrl":"https://doi.org/10.51737/2766-4813.2023.082","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123639582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.063
Y. T, Oklar M, Talan M, Kardas G
Purpose: To evaluate the etiological factors that cause end-stage eye disease or phthisis bulbi requiring enucleation or evisceration and our surgical results. Material and Methods: Medical records of 226 patients, who underwent eye removal surgery, were analyzed retrospectively. Demographic information, clinical history, surgical procedure and histopathological data were all collected. Evisceration surgery was performed under general anesthesia in all patients except tumor cases and one patient with rhino-orbital mucormycosis. The patients were followed for an average of 16.46 ± 10.78 months and checked for the possible complications, cosmetic and functional results. Results: A 144 men, and 82 women, with a mean age of 41.78 ± 22.6 years, were underwent nucleation (n=15) or evisceration (n=211) due to traumatic (n=169) and non-traumatic (n=57) causes. In the traumatic group, 79.8% of 169 patients were injured by penetrating and 14.2% by blunt trauma. A 3.6% of the patients were injured in a traffic accident, and 2.4% of them were injured by explosives. In the non-traumatic group, 40% of 25 patients had post-traumatic endophalmitis, 32% had endophthalmitis due to corneal ulceration and melting, 24% had endophthalmitis after cataract surgery. One patient had panophthalmitis due to rhino-orbital mucormycosis. Another cause in the non-traumatic group was glaucoma, of which 92.3% had neovascular glaucoma and 8.7% had congenital glaucoma. Of the patients who were enucleated for tumor, 35.7% had retinoblastoma, 14.3% had medulloepithelioma, 42.9% had uveal melanoma and 7.1% had metastastatic tumor from paranasal sinuses. The most common complaint in the follow-up period was discharge, seen in all prosthesis wearing patients. 13.3% of the patients had itching due to ocular prosthesis. 4.4% of the patients were complaining about deep superior sulcus. 4.4% had pyogenic granuloma and 17.8% had implant exposure. Conclusion: Etiological factors should be carefully evaluated and precautions should take in order to reduce devastating effect of the physical loss of the eye.
{"title":"Common Causes of Eye Removal Surgery in Turkish Patients: A Review of 226 Cases","authors":"Y. T, Oklar M, Talan M, Kardas G","doi":"10.51737/2766-4813.2022.063","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.063","url":null,"abstract":"Purpose: To evaluate the etiological factors that cause end-stage eye disease or phthisis bulbi requiring enucleation or evisceration and our surgical results. Material and Methods: Medical records of 226 patients, who underwent eye removal surgery, were analyzed retrospectively. Demographic information, clinical history, surgical procedure and histopathological data were all collected. Evisceration surgery was performed under general anesthesia in all patients except tumor cases and one patient with rhino-orbital mucormycosis. The patients were followed for an average of 16.46 ± 10.78 months and checked for the possible complications, cosmetic and functional results. Results: A 144 men, and 82 women, with a mean age of 41.78 ± 22.6 years, were underwent nucleation (n=15) or evisceration (n=211) due to traumatic (n=169) and non-traumatic (n=57) causes. In the traumatic group, 79.8% of 169 patients were injured by penetrating and 14.2% by blunt trauma. A 3.6% of the patients were injured in a traffic accident, and 2.4% of them were injured by explosives. In the non-traumatic group, 40% of 25 patients had post-traumatic endophalmitis, 32% had endophthalmitis due to corneal ulceration and melting, 24% had endophthalmitis after cataract surgery. One patient had panophthalmitis due to rhino-orbital mucormycosis. Another cause in the non-traumatic group was glaucoma, of which 92.3% had neovascular glaucoma and 8.7% had congenital glaucoma. Of the patients who were enucleated for tumor, 35.7% had retinoblastoma, 14.3% had medulloepithelioma, 42.9% had uveal melanoma and 7.1% had metastastatic tumor from paranasal sinuses. The most common complaint in the follow-up period was discharge, seen in all prosthesis wearing patients. 13.3% of the patients had itching due to ocular prosthesis. 4.4% of the patients were complaining about deep superior sulcus. 4.4% had pyogenic granuloma and 17.8% had implant exposure. Conclusion: Etiological factors should be carefully evaluated and precautions should take in order to reduce devastating effect of the physical loss of the eye.","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125298884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2023.080
Zaman F, Akhtar S, Fatema B, B. M
{"title":"Profile of Wound Infection Following Caesarean Delivery at Institute of Child & Mother Health, Matuail, Dhaka","authors":"Zaman F, Akhtar S, Fatema B, B. M","doi":"10.51737/2766-4813.2023.080","DOIUrl":"https://doi.org/10.51737/2766-4813.2023.080","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134542792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2023.073
Snoussi M, Belmekki A
{"title":"Thrombotic Microangiopathy in a Patient with Systemic Lupus Erythematosus","authors":"Snoussi M, Belmekki A","doi":"10.51737/2766-4813.2023.073","DOIUrl":"https://doi.org/10.51737/2766-4813.2023.073","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114711726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.061
Yamashita H, B. H, Kato Y, Ogura K, Sueki E
{"title":"Clinical Improvement of Weight, HbA1c and Liver Function by Rybelsus (Oral Semaglutide) In Patient with Type 2 Diabetes (T2D), Obesity and Fatty Liver","authors":"Yamashita H, B. H, Kato Y, Ogura K, Sueki E","doi":"10.51737/2766-4813.2022.061","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.061","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129182348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.064
P. M.
{"title":"Omicron Variant: Similar or Different Than Other Sars-Cov-2 Variants? Along With Significance of Nanomaterial in Omicron","authors":"P. M.","doi":"10.51737/2766-4813.2022.064","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.064","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130365411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.051
R. N, K. A., Rafia R, M. S., Amin A, A. S., Islam Ms, Hosen A
{"title":"Comparative Study of Nutritional Compounds and Microbial Analysis of Moringa Oleifera (Sajna Leaf) Powder in Different Drying Method during Storage Periods","authors":"R. N, K. A., Rafia R, M. S., Amin A, A. S., Islam Ms, Hosen A","doi":"10.51737/2766-4813.2022.051","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.051","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132268408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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