Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.067
M. N
{"title":"Do Sodium-Glucose Cotransporters Type 2 Inhibitors Cause Hypercalcemia?","authors":"M. N","doi":"10.51737/2766-4813.2022.067","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.067","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133180857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2023.079
Victor P
{"title":"Multiple Sclerosis as a Cause of Disturbances in the Activity of the Heart and Brain; the Role of Glycine and N-Acetylcysteine in the Treatment and Prevention of these Conditions in the Elderly Using Resonance Therapy","authors":"Victor P","doi":"10.51737/2766-4813.2023.079","DOIUrl":"https://doi.org/10.51737/2766-4813.2023.079","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"474 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132023527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2023.069
Arredondo Gp
{"title":"Abdominal Trauma by Firearm in a Malnourished Patient: Clinical Case","authors":"Arredondo Gp","doi":"10.51737/2766-4813.2023.069","DOIUrl":"https://doi.org/10.51737/2766-4813.2023.069","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128786663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2023.078
Yanamadala A
{"title":"A Case Report of High Degree Atrioventricular Block Simulating As a Seizure","authors":"Yanamadala A","doi":"10.51737/2766-4813.2023.078","DOIUrl":"https://doi.org/10.51737/2766-4813.2023.078","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133422530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.049
Marinova L, Vassileva V, Petrov V, Gabrovski I
In improved therapeutic capabilities, late progression of locally advanced HER2 positive breast cancer (BC) is increasingly diagnosed after complex treatment by expression of late solitary brain metastasis (BM). We present a 35-year-old woman with left invasive ductal BC /pT2N1M0, grade G3 with positive estrogen, progesterone and HER2 receptors expression. Complex treatment was carried out, including radical mastectomy with axillary dissection followed by adjuvant treatment- chemotherapy (Ch), radiotherapy (RT), targeted therapy (TT) with trastuzumab and endocrine therapy with LHRH agonist plus tamoxifen. After 8 years a single brain metastasis has been found, extirpated and histologically verified. Postoperative whole-brain radiotherapy (WBRT) up to total dose (TD) 25 Gy with daily dose (DD) 2,5 Gy and boost in brain metastasis up to biologically effective dose/BED 49,5Gy was conducted. August-October 2020 after 1 year of WBRT, against the background of complex treatment with 2 targeted agents/ trastuzumab/pertuzumab and endocrine therapy, CT visualized elevated vasogenic peritumor edema with the progress of the mass effect. The only therapeutic alternative was re-irradiation of brain metastasis by hypofractionated radiosurgery (HFRS). The purpose of this article is to present the efficient healing combination of targeted therapy and HFRS re-irradiation in late solitary BM from HER2 positive BC, not only in terms of local control but also on prolonged survival.
{"title":"Hypofractionated Radiosurgery Re-Irradiation in Large Solitary Brain Metastasis from HER2 Positive Breast Carcinoma","authors":"Marinova L, Vassileva V, Petrov V, Gabrovski I","doi":"10.51737/2766-4813.2022.049","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.049","url":null,"abstract":"In improved therapeutic capabilities, late progression of locally advanced HER2 positive breast cancer (BC) is increasingly diagnosed after complex treatment by expression of late solitary brain metastasis (BM). We present a 35-year-old woman with left invasive ductal BC /pT2N1M0, grade G3 with positive estrogen, progesterone and HER2 receptors expression. Complex treatment was carried out, including radical mastectomy with axillary dissection followed by adjuvant treatment- chemotherapy (Ch), radiotherapy (RT), targeted therapy (TT) with trastuzumab and endocrine therapy with LHRH agonist plus tamoxifen. After 8 years a single brain metastasis has been found, extirpated and histologically verified. Postoperative whole-brain radiotherapy (WBRT) up to total dose (TD) 25 Gy with daily dose (DD) 2,5 Gy and boost in brain metastasis up to biologically effective dose/BED 49,5Gy was conducted. August-October 2020 after 1 year of WBRT, against the background of complex treatment with 2 targeted agents/ trastuzumab/pertuzumab and endocrine therapy, CT visualized elevated vasogenic peritumor edema with the progress of the mass effect. The only therapeutic alternative was re-irradiation of brain metastasis by hypofractionated radiosurgery (HFRS). The purpose of this article is to present the efficient healing combination of targeted therapy and HFRS re-irradiation in late solitary BM from HER2 positive BC, not only in terms of local control but also on prolonged survival.","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131316947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.057
Koch Ba, Uflacker L
{"title":"Prolonged Survival in Metastatic Gastrointestinal Cancer and the Significance of the Modulation of the Activity of Cells of the Tumor Microenvironment","authors":"Koch Ba, Uflacker L","doi":"10.51737/2766-4813.2022.057","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.057","url":null,"abstract":"","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120977778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51737/2766-4813.2022.060
J. Z., L. L., Zhenyun Y, C. H., J. Y, S. H
Cerebral Small Vessel Disease (CSVD) is not only a single disease, but a kind of clinical and pathological syndrome caused by various factors, such as intracranial arterioles, perforating arteries and venules, which can result in structural and functional changes. CSVD accounts for about 25% of ischemic stroke. It is related to cognitive dysfunction, emotional disorder and even defecation disorder in the elderly, which seriously affects the quality of life. The clinical manifestations and prognosis that different patients suffer from are different. The reasons why some patients’ clinical symptoms are differ from others’ are that besides stroke location, stroke area and other factors we talked about usually, in addition, inflammatory immune response also plays an significant role in CSVD. Inflammatory response is a defense mechanism for us, so that we can respond to a variety of stimulating factors quickly, by causing a series of effects such as activating inflammatory cells to release inflammatory factors and other bioactive substances. Similarly, the immune system of our body is composed of a variety of immune organs and immune cells, which has the functions of immune defense and immune regulation. Inflammatory immune response occurs in all systems of the body, which is regulated by immune cells, inflammatory factors and other mediators, and plays an important role in the occurrence and development of diseases.
脑血管病(Cerebral Small Vessel Disease, CSVD)不仅仅是一种单一的疾病，而是一种由颅内小动脉、穿通动脉和小静脉等多种因素引起的临床和病理综合征，可导致结构和功能的改变。CSVD约占缺血性卒中的25%。它与老年人的认知功能障碍、情绪障碍甚至排便障碍有关，严重影响生活质量。不同患者的临床表现及预后不同。有些患者的临床症状与其他患者不同的原因是，除了我们通常所说的卒中部位、卒中面积等因素外，炎症免疫反应在CSVD中也起着重要作用。炎症反应是我们的一种防御机制，通过引起激活炎症细胞释放炎症因子等生物活性物质等一系列作用，使我们对多种刺激因子迅速作出反应。同样，我们身体的免疫系统是由多种免疫器官和免疫细胞组成的，具有免疫防御和免疫调节的功能。炎症免疫反应存在于机体的各个系统，受免疫细胞、炎症因子等介质的调节，在疾病的发生发展中起着重要作用。
{"title":"The Relationship between Cerebral Small Vessel Disease and Inflamate-Immune Response: A Review","authors":"J. Z., L. L., Zhenyun Y, C. H., J. Y, S. H","doi":"10.51737/2766-4813.2022.060","DOIUrl":"https://doi.org/10.51737/2766-4813.2022.060","url":null,"abstract":"Cerebral Small Vessel Disease (CSVD) is not only a single disease, but a kind of clinical and pathological syndrome caused by various factors, such as intracranial arterioles, perforating arteries and venules, which can result in structural and functional changes. CSVD accounts for about 25% of ischemic stroke. It is related to cognitive dysfunction, emotional disorder and even defecation disorder in the elderly, which seriously affects the quality of life. The clinical manifestations and prognosis that different patients suffer from are different. The reasons why some patients’ clinical symptoms are differ from others’ are that besides stroke location, stroke area and other factors we talked about usually, in addition, inflammatory immune response also plays an significant role in CSVD. Inflammatory response is a defense mechanism for us, so that we can respond to a variety of stimulating factors quickly, by causing a series of effects such as activating inflammatory cells to release inflammatory factors and other bioactive substances. Similarly, the immune system of our body is composed of a variety of immune organs and immune cells, which has the functions of immune defense and immune regulation. Inflammatory immune response occurs in all systems of the body, which is regulated by immune cells, inflammatory factors and other mediators, and plays an important role in the occurrence and development of diseases.","PeriodicalId":166084,"journal":{"name":"SunText Review of Medical & Clinical Research","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126137224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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