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A qualitative investigation to identify return to sports criteria after shoulder stabilization surgery used by professional team physicians. 一项定性调查,以确定由专业团队医生使用的肩部稳定手术后恢复运动标准。
IF 1.6 4区 医学 Pub Date : 2024-09-01 DOI: 10.1177/10225536241302219
Mike Szlufcik, Mario Pasurka, John Theodoropoulos, Marcel Betsch

Purpose: Purpose of this study is to explore currently utilized readiness to return to sports (RTS) criteria after shoulder stabilization surgery used in elite athletes to gain novel insights into the RTS decision making process of professional team physicians.Methods: 19 qualitative semi-structured interviews with professional team physicians were conducted by a single trained interviewer. The interviews were used to identify team physician concepts and themes regarding the criteria used to determine RTS after shoulder stabilization surgery. General inductive analysis and a coding process were used to identify themes and sub-themes arising from the data. A hierarchical approach in coding helped to link themes.Results: We were able to identify five key themes that participating physicians focused on to determine RTS decision making: external influence, objective and subjective criteria, time elapsed since surgery and type of sport. The most important RTS criteria included: range of motion and muscle strength followed by clinical joint stability, time since surgery, ability of sporting movement, psychological readiness, functional testing, absence of pain and allied team support.Conclusion: This study identified several main themes and subordinate minor themes as having the most influence on RTS decision after shoulder surgery. We showed that even among specialized professional team physicians, the main criteria to RTS in these categories were inconsistent necessitating the future development of specific RTS guidelines.

目的:本研究的目的是探讨目前使用的精英运动员肩部稳定手术后重返运动准备(RTS)标准,以获得专业团队医生的RTS决策过程的新见解。方法:由一名训练有素的采访者对专业团队医生进行19次定性半结构化访谈。访谈用于确定团队医生关于确定肩部稳定手术后RTS标准的概念和主题。一般归纳分析和编码过程被用来确定从数据产生的主题和子主题。编码中的分层方法有助于将主题联系起来。结果:我们能够确定参与的医生在决定RTS决策时关注的五个关键主题:外部影响、客观和主观标准、手术后经过的时间和运动类型。最重要的RTS标准包括:运动范围和肌肉力量,其次是临床关节稳定性,手术后时间,运动能力,心理准备,功能测试,疼痛消失和团队支持。结论:本研究确定了几个主要主题和次要主题对肩部手术后的RTS决策影响最大。我们发现,即使在专业的专业团队医生中,这些类别的RTS主要标准也不一致,因此需要未来制定具体的RTS指南。
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引用次数: 0
Use of tourniquet in anterior cruciate ligament reconstruction: Is it truly necessary? A prospective randomized clinical trial. 在前十字韧带重建术中使用止血带:真的有必要吗?一项前瞻性随机临床试验。
IF 1.6 4区 医学 Pub Date : 2024-09-01 DOI: 10.1177/10225536241293538
Riccardo D'Ambrosi, Federico Valli, Fabrizio Di Feo, Pietro Marchetti, Nicola Ursino

Purpose: To examine the effects of tourniquet use in arthroscopic anterior cruciate ligament reconstruction in terms of (1) intraoperative visualization, (2) surgical time, (3) consumption of sterile saline, and (4) postoperative pain.

Methods: In this prospective randomized clinical trial, patients were assigned to Tourniquet Group or No Tourniquet treatment groups. The primary outcomes were intraoperative visualization, with scores ranging from 0 to 10 (0 = no visibility; 10 = clear and perfect display), surgical time, and the consumption of sterile saline. The secondary aim was to measure postoperative pain (24 h after surgery) with the visual analog scale (VAS) for pain.

Results: A total of 71 patients were included in the No Tourniquet group, and 75 were included in the Tourniquet group, with mean ages of 26.73 ± 8.05 years and 26.95 ± 10.11 years, respectively (p = .88). In the No Tourniquet group, 37 concomitant meniscal lesions were treated, whereas in the Tourniquet group, 38 (p = .99) were treated. The mean surgical times were 51.07 ± 6.90 and 50.03 ± 7.62 (p = .325), respectively, while the mean amount of saline consumed was 6.17 ± 1.18 L versus 5.89 ± 1.23 L (p = .217). Both groups achieved optimal visualization, with a sum of all surgical steps of 65.49 ± 1.86 for the no tourniquet group and 65.39 ± 1.88 for the Tourniquet group (p = .732). Postoperative pain was significantly lower in the No Tourniquet group (VAS score: 2.82 ± 1.33 vs 5.80 ± 1.22).

Conclusions: Tourniquet use during ACL reconstruction does not improve intraoperative visualization and does not reduce surgical time but leads to greater postoperative pain with a risk of well-known tourniquet-related complications.

Level of evidence: Level I - Randomized clinical trial.

目的:研究在关节镜前交叉韧带重建术中使用止血带对以下方面的影响:(1) 术中可视化;(2) 手术时间;(3) 无菌生理盐水的消耗量;(4) 术后疼痛:在这项前瞻性随机临床试验中,患者被分配到止血带组和无止血带组。主要结果是术中可视度,评分范围为 0-10 分(0 = 无可视度;10 = 显示清晰完美)、手术时间和无菌生理盐水消耗量。次要目的是用疼痛视觉模拟量表(VAS)测量术后疼痛(术后 24 小时):无止血带组共有 71 名患者,止血带组共有 75 名患者,平均年龄分别为(26.73 ± 8.05)岁和(26.95 ± 10.11)岁(P = .88)。在无止血带组中,有 37 例合并半月板病变的患者接受了治疗,而在止血带组中,有 38 例合并半月板病变的患者接受了治疗(p = .99)。平均手术时间分别为 51.07 ± 6.90 和 50.03 ± 7.62 (p = .325),平均生理盐水消耗量分别为 6.17 ± 1.18 L 和 5.89 ± 1.23 L (p = .217)。两组都达到了最佳视野,无止血带组所有手术步骤的总和为 65.49 ± 1.86,止血带组为 65.39 ± 1.88(p = .732)。无止血带组的术后疼痛明显减轻(VAS评分:2.82 ± 1.33 vs 5.80 ± 1.22):结论:在前交叉韧带重建过程中使用止血带不会改善术中可视化,也不会缩短手术时间,但会导致术后疼痛加剧,并有可能出现众所周知的止血带相关并发症:I级--随机临床试验。
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引用次数: 0
Oblique sliding ulna osteotomy to treat paediatric neglected monteggia fracture dislocation. 斜向滑动尺骨截骨术治疗小儿被忽视的畸形骨折脱位。
IF 1.6 4区 医学 Pub Date : 2024-09-01 DOI: 10.1177/10225536241286104
Nik Alyani Nik Abdul Adel, Emil Fazliq Mohd, Ismail Munajat, Abdul Razak Sulaiman

Introduction: There have been osteotomy methods that corrected or overcorrected the ulna deformity as part of surgical treatment for chronic radial head dislocation.

Methodology: We reported surgical technique and outcome of oblique sliding ulna osteotomy that created acute lengthening, deformity correction or both to assist open reduction of radiocapitellar joint in four patients with neglected Monteggia fracture dislocation.

Result: Patients aged 3-12 years old had trauma duration of 4 weeks to 3 years. Two patients had Bado type I injury, and the other two had Bado type III. There was no acute nerve injury. During the final follow-up, all patients achieved union, with the limitation of motion range in the rotation arch being less than 20°. The radial head had no recurrent dislocation.

Conclusion: This case series has shown sliding osteotomy safely, providing acute correction and lengthening of the ulna without requiring bone graft to facilitate stable reduction of the neglected Monteggia lesion.

导言:作为慢性桡骨头脱位手术治疗的一部分,曾有过矫正或过度矫正尺骨畸形的截骨方法:我们报告了4例被忽视的Monteggia骨折脱位患者的斜滑尺桡骨截骨术的手术技巧和结果,该截骨术可实现急性延长、畸形矫正或两者兼而有之,以辅助桡骨髌骨关节的开放复位:患者年龄在 3-12 岁之间,创伤持续时间为 4 周至 3 年。两名患者为巴多Ⅰ型损伤,另外两名为巴多Ⅲ型损伤。没有急性神经损伤。在最后的随访中,所有患者都达到了骨结合,旋转弓的活动范围小于20°。桡骨头无复发性脱位:本系列病例显示,滑动截骨术非常安全,可在不需要植骨的情况下对尺骨进行急性矫正和延长,从而促进被忽视的Monteggia病变的稳定缩小。
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引用次数: 0
Comparative analysis and validation of posterior cruciate ligament management in mobile-bearing total knee arthroplasty: Meta-analysis and animal study. 活动承载式全膝关节置换术中后交叉韧带处理的比较分析和验证:荟萃分析和动物实验。
IF 1.6 4区 医学 Pub Date : 2024-09-01 DOI: 10.1177/10225536241287910
Yuan-Shi Zhang, Hao-Yu Li, Lei Zhai, Gui-Zhou Zheng, Hong-Bo Xing, Shi-Xin Du, Xue-Dong Li

Total knee arthroplasty (TKA) is an effective treatment for end-stage knee joint diseases. The debate over preserving or sacrificing the posterior cruciate ligament (PCL) in mobile-bearing TKA (MB TKA) still needs to be solved due to the lack of high-quality evidence, particularly meta-analyses comparing these techniques. This study aims to conduct a meta-analysis to compare the outcomes of PCL retention (CR) and PCL sacrifice (PS) in terms of clinical and functional knee scores, range of motion, complication rates, and revision rates and to validate these findings through animal experiments. A comprehensive search was conducted using MEDLINE, Cochrane, and Embase databases. Relevant studies were selected for the meta-analysis using RevMan 5.3. Additionally, an animal experiment using Sprague-Dawley rats simulated MB TKA to compare the effects of PCL retention and sacrifice surgeries. 12 studies were included in the meta-analysis. No significant differences were found between CR and PS techniques regarding HSS, KSS, KSFS, WOMAC, ROM, and medial/lateral instability. However, CR MB showed slight superiority in NKJS, while PS MB had better outcomes in complication and revision rates. In the animal study, CR rats exhibited significant early postoperative inflammation, but both groups' knee structures gradually normalized. The meta-analysis indicates that PCL retention (CR MB) and sacrifice (PS MB) have similar effects on various clinical and functional knee scores. However, PS MB is significantly better at reducing complications and revision rates. The animal experiment confirms PS MB's advantages in reducing inflammation and promoting joint recovery. Despite the strong evidence, long-term follow-up and larger-scale randomized controlled trials are necessary to confirm these findings.

全膝关节置换术(TKA)是治疗终末期膝关节疾病的有效方法。由于缺乏高质量的证据,尤其是缺乏比较这两种技术的荟萃分析,在活动承载式全膝关节置换术(MB TKA)中保留或牺牲后交叉韧带(PCL)的争论仍有待解决。本研究旨在进行一项荟萃分析,从临床和膝关节功能评分、活动范围、并发症发生率和翻修率等方面比较 PCL 保留(CR)和 PCL 牺牲(PS)的结果,并通过动物实验验证这些发现。我们使用 MEDLINE、Cochrane 和 Embase 数据库进行了全面检索。使用 RevMan 5.3 挑选出相关研究进行荟萃分析。此外,还使用 Sprague-Dawley 大鼠进行了模拟 MB TKA 的动物实验,以比较 PCL 保留和牺牲手术的效果。12 项研究被纳入荟萃分析。在HSS、KSS、KSFS、WOMAC、ROM和内侧/外侧不稳定性方面,CR和PS技术没有发现明显差异。不过,CR MB 在 NKJS 方面略胜一筹,而 PS MB 在并发症和翻修率方面效果更好。在动物实验中,CR 组大鼠在术后早期表现出明显的炎症,但两组大鼠的膝关节结构都逐渐恢复正常。荟萃分析表明,保留 PCL(CR MB)和牺牲 PCL(PS MB)对各种临床和膝关节功能评分的影响相似。然而,PS MB在减少并发症和翻修率方面明显更胜一筹。动物实验证实了 PS MB 在减少炎症和促进关节恢复方面的优势。尽管证据确凿,但仍需长期随访和更大规模的随机对照试验来证实这些发现。
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引用次数: 0
Uric acid-to-high-density lipoprotein cholesterol ratio and osteoporosis: Evidence from the national health and nutrition examination survey. 尿酸与高密度脂蛋白胆固醇的比率与骨质疏松症:来自全国健康与营养调查的证据。
IF 1.6 4区 医学 Pub Date : 2024-09-01 DOI: 10.1177/10225536241293489
Zeyu Liu, Yuchen Tang, Ying Sun, Miao Lei, Minghuang Cheng, Xiaohan Pan, Zhenming Hu, Jie Hao

Background: The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel indicator of inflammatory and metabolic status. This study aims to examine the association between UHR and bone mineral density (BMD), as well as the risk of osteoporosis, in individuals aged ≥50 years. Methods: This cross-sectional study used data from the National Health and Nutrition Examination Survey, focusing on participants aged ≥50 years. Femoral neck BMD (FN-BMD) was measured using dual-energy X-ray absorptiometry. Linear regression models were employed to examine the association between UHR and FN-BMD. Additionally, generalised additive models were used to assess the nonlinear relationship between UHR and FN-BMD. Logistic regression models were employed to evaluate the association between UHR and the risk of osteoporosis. Results: Finally, the study included 2963 adults with a mean age of 64.16 ± 8.92 years. Linear regression analyses revealed a positive association between UHR and FN-BMD, regardless of covariate adjustments. Logistic regression analyses indicated that elevated UHR was associated with a reduced risk of osteoporosis with or without covariate adjustments. Subgroup analyses revealed that the positive association between UHR and BMD was significant in individuals aged ≥65 years but not in those aged 50 to 64 years. Interaction analyses by age showed significant differences after adjusting for all covariates. Conclusions: Clinicians should be vigilant regarding the potential risk of osteoporosis in individuals with a low UHR. UHR might serve as a risk indicator for osteoporosis.

背景:尿酸与高密度脂蛋白胆固醇比值(UHR)已成为炎症和代谢状况的新指标。本研究旨在探讨尿酸与高密度脂蛋白胆固醇比值(UHR)与骨矿物质密度(BMD)以及骨质疏松症风险之间的关系。研究方法这项横断面研究使用了美国国家健康与营养调查的数据,主要针对年龄≥50 岁的参与者。股骨颈 BMD(FN-BMD)采用双能 X 射线吸收测量法进行测量。采用线性回归模型来研究 UHR 与 FN-BMD 之间的关系。此外,还采用了广义相加模型来评估 UHR 与 FN-BMD 之间的非线性关系。逻辑回归模型用于评估 UHR 与骨质疏松症风险之间的关系。研究结果最后,研究纳入了 2963 名成年人,平均年龄为 64.16 ± 8.92 岁。线性回归分析表明,无论协变量如何调整,UHR 与 FN-BMD 之间均呈正相关。逻辑回归分析表明,无论是否进行协变量调整,UHR 升高都与骨质疏松症风险降低有关。亚组分析显示,UHR 与 BMD 之间的正相关在年龄≥65 岁的人群中显著,而在 50 至 64 岁的人群中则不显著。在对所有协变量进行调整后,按年龄进行的交互分析显示出显著差异。结论:临床医生应警惕 UHR 偏低者患骨质疏松症的潜在风险。UHR可作为骨质疏松症的风险指标。
{"title":"Uric acid-to-high-density lipoprotein cholesterol ratio and osteoporosis: Evidence from the national health and nutrition examination survey.","authors":"Zeyu Liu, Yuchen Tang, Ying Sun, Miao Lei, Minghuang Cheng, Xiaohan Pan, Zhenming Hu, Jie Hao","doi":"10.1177/10225536241293489","DOIUrl":"10.1177/10225536241293489","url":null,"abstract":"<p><p><b>Background:</b> The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel indicator of inflammatory and metabolic status. This study aims to examine the association between UHR and bone mineral density (BMD), as well as the risk of osteoporosis, in individuals aged ≥50 years. <b>Methods:</b> This cross-sectional study used data from the National Health and Nutrition Examination Survey, focusing on participants aged ≥50 years. Femoral neck BMD (FN-BMD) was measured using dual-energy X-ray absorptiometry. Linear regression models were employed to examine the association between UHR and FN-BMD. Additionally, generalised additive models were used to assess the nonlinear relationship between UHR and FN-BMD. Logistic regression models were employed to evaluate the association between UHR and the risk of osteoporosis. <b>Results:</b> Finally, the study included 2963 adults with a mean age of 64.16 ± 8.92 years. Linear regression analyses revealed a positive association between UHR and FN-BMD, regardless of covariate adjustments. Logistic regression analyses indicated that elevated UHR was associated with a reduced risk of osteoporosis with or without covariate adjustments. Subgroup analyses revealed that the positive association between UHR and BMD was significant in individuals aged ≥65 years but not in those aged 50 to 64 years. Interaction analyses by age showed significant differences after adjusting for all covariates. <b>Conclusions:</b> Clinicians should be vigilant regarding the potential risk of osteoporosis in individuals with a low UHR. UHR might serve as a risk indicator for osteoporosis.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"32 3","pages":"10225536241293489"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-value surgical innovation under peer-review: A sham study of abstracts on proximal humerus fractures submitted to scientific meetings. 同行评审下的低价值外科创新:对提交给科学会议的肱骨近端骨折摘要的虚假研究。
IF 1.6 4区 医学 Pub Date : 2024-09-01 DOI: 10.1177/10225536241292397
Sam Razaeian, Dafang Zhang, Christian Krettek

Background: Innovation has in common the promise of benefit for patients; however, past experience has shown that this promise is not always delivered. Instead, low-value innovation might encourage treatment variation and dilute the available body of evidence. This study aims to investigate (1) whether the peer-review process is capable of filtering out low-value innovation appropriately, and (2) whether low-value surgical innovation would be preferred more often than nonoperative innovation by peer-reviewers in the treatment of proximal humeral fractures in the elderly.

Materials and methods: Two duplicated sham scientific abstracts, respectively introducing a low-value surgical innovation and a valuable nonsurgical innovation, were submitted to nineteen peer-reviewed scientific meetings worldwide for orthopedic trauma surgery with submission deadlines between 01/01/2022 and 31/12/2022. Decision regarding abstract acceptance was compared.

Results: There was a high acceptance rate for the abstract introducing low-value surgical innovation (12 out of 19 (63.2 %)), which was higher than that of a nonoperative duplicate (10 out of 19 (52.6 %)), but this difference was not statistically significant (p = 0.5). The majority of the ten meetings that accepted both abstracts placed both in equivalent programmatic tiers (oral presentation (4) and poster presentation (2)). In three meetings, the surgical abstract received superior program placement (oral presentation). In one case, it was the opposite.

Conclusion: There is a high acceptance rate for low-value surgical innovation among peer-reviewed scientific meetings. However, we can not conclude that low-value surgical innovation is preferred more often than nonoperative innovation by peer-reviewers as the differences in acceptance rate were small and not statistically significant. The peer-review process may be suitable as value-based medicine emerges. Scientists should be encouraged to pursue value-based innovation.

背景:创新的共同点是承诺为患者带来益处;然而,过去的经验表明,这种承诺并非总能兑现。相反,低价值的创新可能会鼓励治疗方法的变化,并稀释现有的证据。本研究旨在调查:(1)同行评议过程是否能够适当过滤掉低价值创新;(2)在治疗老年人肱骨近端骨折时,同行评议者是否更倾向于低价值的手术创新而非非手术创新:向全球 19 个创伤骨科同行评审科学会议提交两份重复的假科学摘要,分别介绍一种低价值的手术创新和一种有价值的非手术创新,提交截止日期为 2022 年 1 月 1 日至 12 月 31 日。对摘要的接受决定进行了比较:结果:介绍低价值手术创新的摘要接受率较高(19 篇中有 12 篇(63.2%)),高于非手术重复摘要的接受率(19 篇中有 10 篇(52.6%)),但差异无统计学意义(P = 0.5)。在接受两篇摘要的 10 个会议中,大多数会议都将两篇摘要放在同等的计划层级(口头报告(4)和海报报告(2))。在三次会议上,外科手术摘要获得了较好的程序安排(口头报告)。结论:结论:在同行评审科学会议中,低价值外科创新的接受率很高。然而,我们并不能得出结论说,低价值的手术创新比非手术创新更受同行评审者的青睐,因为接受率的差异很小,在统计学上并不显著。随着以价值为基础的医学的出现,同行评审程序可能会变得合适。应鼓励科学家追求基于价值的创新。
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引用次数: 0
The effectiveness of microfracture augmentation on the wall of femoral condyle in meniscal healing among patients with meniscus tears after sports injury. 股骨髁壁微骨折增强在运动损伤后半月板撕裂患者半月板愈合中的作用。
IF 1.6 4区 医学 Pub Date : 2024-09-01 DOI: 10.1177/10225536241306169
Leonard Christianto Singjie, Muhammad Sakti, Notinas Horas, Dario Agustino Nelwan

Background: Meniscus injuries are familiar sources of knee pain, with meniscus repair sometimes yielding unsatisfactory results. Microfracture is a standard procedure for treating articular cartilage damage in the knee that promotes the formation of fibrocartilage over damaged cartilage. Microfracture enhanced the healing rate of meniscus repair in animal models.

Objective: Investigate the effectiveness of microfracture augmentation on the wall of femoral condyle in meniscus healing among patients with meniscus repair.

Methods: The current study, conducted in a single center, involved patients with red-white zone meniscal tears due to sports injury who underwent arthroscopic meniscus repair between January 2018 and December 2023. Meniscal repair was performed without microfracture in the control group but with microfracture augmentation in the intervention group.

Results: Functional outcomes, assessed using the Lysholm score, were significantly better in the microfracture group (p = 0.000). Both groups showed significant reductions in tear size according to its intensity on magnetic resonance imaging (MRI) (p = 0.002 in the control group and p = 0.001 in the microfracture group), with a notably better meniscus healing rate (35.7%) in the microfracture group compared to the control group.

Conclusion: This initial study highlights substantial effectiveness between meniscus repair augmented with microfracture and enhanced healing compared to repair without microfracture. Functional scores were notably higher, and MRI signal intensity decreased to grade 1 in a significant portion of patients in the microfracture group.

背景:半月板损伤是常见的膝关节疼痛来源,半月板修复有时效果不理想。微骨折是治疗膝关节关节软骨损伤的标准方法,可促进受损软骨上纤维软骨的形成。在动物模型中,微骨折可提高半月板修复的愈合率。目的:探讨股骨髁壁微骨折增强对半月板修复患者半月板愈合的影响。方法:目前的研究是在单一中心进行的,涉及2018年1月至2023年12月期间接受关节镜半月板修复术的运动损伤红白带半月板撕裂患者。对照组进行半月板修复,无微骨折,干预组进行微骨折增强。结果:使用Lysholm评分评估的功能结果,微骨折组明显更好(p = 0.000)。根据磁共振成像(MRI)显示,两组患者的撕裂大小均显著减小(对照组p = 0.002,微骨折组p = 0.001),微骨折组的半月板愈合率(35.7%)明显优于对照组。结论:这项初步研究强调了与不带微骨折的半月板修复相比,带微骨折的半月板修复和增强愈合之间的实质性效果。功能评分明显较高,微骨折组中相当一部分患者的MRI信号强度降至1级。
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引用次数: 0
Exploring Denosumab's potential in aneurysmal bone cyst treatment: A scoping review. 探索地诺单抗在动脉瘤性骨囊肿治疗中的潜力:范围综述。
IF 1.6 4区 医学 Pub Date : 2024-09-01 DOI: 10.1177/10225536241297105
Vinesh Sandhu, Vivek Ajit Singh, Ajay Puri

Background: Denosumab effectively treats RANKL-mediated bone disorders by inhibiting osteoclast activity. While approved for giant cell tumours, its role in aneurysmal bone cysts (ABC) remains unclear. This review explores denosumab's application in ABCs, focusing on its role, outcomes, and adverse effects. Methods: A scoping review adhering to PRISMA Extension for Scoping Reviews guidelines was conducted. The search involved five databases from inception until 31 December 2023. Results: From an initial 390 studies, 29 were selected post-screening involving 67 patients. The most common ABC sites were the spine (n = 42) and pelvis (n = 7). Denosumab served as primary treatment in 25 patients (37.3%), neoadjuvant in 11 (16.4%), second-line therapies after inadequate initial therapies in 24 (35.8%), and adjunct therapy in seven cases. All patients demonstrated favourable clinical and radiological responses post-denosumab. 10 patients (15%) experienced tumour recurrences: six after denosumab discontinuation (3-17 months post-cessation), three post-surgery following neoadjuvant denosumab, and one during ongoing treatment. Adverse effects reported were hypocalcaemia (n = 10), hypercalcemia (n = 14), and sclerotic metaphyseal bands (n = 2), all in the paediatric age group. While hypocalcaemia surfaced early in denosumab therapy, hypercalcaemia manifested 2.5-6 months post-discontinuation, mainly managed with bisphosphonates. Fewer than half of the studies had follow-ups that exceeded 2 years. Conclusion: Denosumab may be an effective therapy for ABC, especially for high-risk cases like spinal and pelvic tumours. It can also be utilized as a second-line for recurrence/failed initial intervention or as neoadjuvant therapy. Concerns exist about tumour recurrence and rebound hypercalcemia, necessitating careful monitoring, longer follow-up, and prophylactic measures. Prospective clinical trials are warranted for deeper insights.

背景地诺单抗通过抑制破骨细胞的活性,有效治疗 RANKL 介导的骨疾病。虽然地诺单抗已被批准用于治疗巨细胞瘤,但其在动脉瘤性骨囊肿(ABC)中的作用仍不明确。本综述探讨了地诺单抗在动脉瘤骨囊肿中的应用,重点关注其作用、疗效和不良反应。方法:按照PRISMA扩展范围综述指南进行了范围综述。从开始到 2023 年 12 月 31 日,共检索了五个数据库。结果从最初的 390 项研究中,筛选出 29 项,涉及 67 名患者。最常见的ABC部位是脊柱(42例)和骨盆(7例)。25名患者(37.3%)接受了地诺单抗作为主要治疗手段,11名患者(16.4%)接受了新辅助治疗,24名患者(35.8%)在初始治疗效果不佳后接受了二线治疗,7名患者接受了辅助治疗。所有患者在接受地诺单抗治疗后均有良好的临床和放射学反应。10例患者(15%)出现肿瘤复发:6例在停用地诺单抗后(停药后3-17个月)复发,3例在新辅助地诺单抗治疗后的手术后复发,1例在持续治疗期间复发。报告的不良反应包括低钙血症(10 例)、高钙血症(14 例)和骨骺硬化带(2 例),均发生在儿童年龄组。低钙血症出现在地诺单抗治疗的早期,而高钙血症则出现在停药后的 2.5-6 个月,主要通过双膦酸盐治疗。只有不到一半的研究随访时间超过 2 年。结论地诺单抗可能是治疗ABC的有效方法,尤其是对于脊柱和盆腔肿瘤等高风险病例。它还可作为复发/初次干预失败的二线治疗或新辅助治疗。肿瘤复发和反弹性高钙血症是令人担忧的问题,因此有必要进行仔细监测、延长随访时间并采取预防措施。需要进行前瞻性临床试验,以获得更深入的见解。
{"title":"Exploring Denosumab's potential in aneurysmal bone cyst treatment: A scoping review.","authors":"Vinesh Sandhu, Vivek Ajit Singh, Ajay Puri","doi":"10.1177/10225536241297105","DOIUrl":"10.1177/10225536241297105","url":null,"abstract":"<p><p><b>Background:</b> Denosumab effectively treats RANKL-mediated bone disorders by inhibiting osteoclast activity. While approved for giant cell tumours, its role in aneurysmal bone cysts (ABC) remains unclear. This review explores denosumab's application in ABCs, focusing on its role, outcomes, and adverse effects. <b>Methods:</b> A scoping review adhering to PRISMA Extension for Scoping Reviews guidelines was conducted. The search involved five databases from inception until 31 December 2023. <b>Results:</b> From an initial 390 studies, 29 were selected post-screening involving 67 patients. The most common ABC sites were the spine (<i>n</i> = 42) and pelvis (<i>n</i> = 7). Denosumab served as primary treatment in 25 patients (37.3%), neoadjuvant in 11 (16.4%), second-line therapies after inadequate initial therapies in 24 (35.8%), and adjunct therapy in seven cases. All patients demonstrated favourable clinical and radiological responses post-denosumab. 10 patients (15%) experienced tumour recurrences: six after denosumab discontinuation (3-17 months post-cessation), three post-surgery following neoadjuvant denosumab, and one during ongoing treatment. Adverse effects reported were hypocalcaemia (<i>n</i> = 10), hypercalcemia (<i>n</i> = 14), and sclerotic metaphyseal bands (<i>n</i> = 2), all in the paediatric age group. While hypocalcaemia surfaced early in denosumab therapy, hypercalcaemia manifested 2.5-6 months post-discontinuation, mainly managed with bisphosphonates. Fewer than half of the studies had follow-ups that exceeded 2 years. <b>Conclusion:</b> Denosumab may be an effective therapy for ABC, especially for high-risk cases like spinal and pelvic tumours. It can also be utilized as a second-line for recurrence/failed initial intervention or as neoadjuvant therapy. Concerns exist about tumour recurrence and rebound hypercalcemia, necessitating careful monitoring, longer follow-up, and prophylactic measures. Prospective clinical trials are warranted for deeper insights.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"32 3","pages":"10225536241297105"},"PeriodicalIF":1.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to full weight-bearing with the use of a calcium sulfate-calcium phosphate bone substitute as a bone void filler following extended curettage in the treatment of primary benign bone tumours. 使用硫酸钙-磷酸钙骨替代物作为骨空隙填充物治疗原发性良性骨肿瘤后的完全负重时间。
IF 1.6 4区 医学 Pub Date : 2024-05-01 DOI: 10.1177/10225536241254200
Lauren Gyemi, Asher Selznick, Brad Petrisor, Michelle Ghert

Purpose: The primary objective of this study was to determine time to full weight-bearing after the use of a calcium-sulfate-calcium phosphate bone substitute (CaSO4/CaPO4) as a bone void filler in the treatment of primary benign bone tumours following intralesional curettage. The secondary objectives were to determine surgical complications and recurrence rates.

Methods: Retrospective review of patients identified from a surgeon-specific orthopaedic oncology database, who underwent curettage of benign bone tumours and subsequent bone void filling with CaSO4/CaPO4.

Results: A total of 39 patients (20 males, 19 females) met inclusion criteria with an average age of 31 years (range: 13 to 62 years), a median follow-up of 3.7 years, and a maximum follow-up of 11 years. The most common tumour diagnosis was giant cell tumour of bone (GCT) (n = 19), and the most common location was the proximal tibia (n = 9). The mean volume of tumour excised was 74.1 cm3 including extraosseous bone expansion due to tumour growth, with a mean of volume of 21.4 mL of CaSO4/CaPO4 used to fill the intraosseous cavitary defects to restore normal bone anatomy. None of the lesions required additional internal fixation. The primary outcome measure, average time to full weight-bearing/full range of motion, was 11 weeks and 6 weeks for upper and lower extremity lesions, respectively. Secondary outcomes included tumour recurrence requiring reoperation in five patients and infection requiring reoperation in two patients.

Conclusion: This study demonstrates that CaSO4/CaPO4 is a viable option as a bone void filler in the reconstruction of cavitary defects following removal of primary benign bone tumours. CaSO4/CaPO4 provides sufficient bone regeneration early in the post-operative period to allow progression to full weight-bearing within weeks without the need for internal fixation. There were no graft-specific complications noted.

目的:本研究的主要目的是确定在使用硫酸钙-磷酸钙骨替代物(CaSO4/CaPO4)作为骨空隙填充物治疗原发性良性骨肿瘤后,患者完全负重所需的时间。次要目标是确定手术并发症和复发率:方法:对外科医生特定的骨科肿瘤数据库中确定的接受良性骨肿瘤刮除术并随后使用 CaSO4/CaPO4 进行骨空隙填充的患者进行回顾性研究:共有 39 名患者(20 名男性,19 名女性)符合纳入标准,平均年龄为 31 岁(范围:13 至 62 岁),中位随访时间为 3.7 年,最长随访时间为 11 年。最常见的肿瘤诊断是骨巨细胞瘤(GCT)(19 例),最常见的部位是胫骨近端(9 例)。切除肿瘤的平均体积为74.1立方厘米,其中包括因肿瘤生长而导致的骨外骨膨胀,平均21.4毫升的CaSO4/CaPO4用于填充骨内空腔缺损,以恢复正常的骨解剖结构。没有一个病灶需要额外的内固定。主要结果是上肢和下肢病变完全负重/完全活动范围的平均时间分别为11周和6周。次要结果包括五名患者肿瘤复发需要再次手术,两名患者感染需要再次手术:本研究表明,CaSO4/CaPO4 是一种可行的骨空隙填充物,可用于原发性良性骨肿瘤切除后空腔缺损的重建。CaSO4/CaPO4能在术后早期提供足够的骨再生,使患者在数周内就能完全负重,而无需进行内固定。没有发现移植物特有的并发症。
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引用次数: 0
Surface electromyography analysis of ankle flexor and extensor activity under different standing stability levels. 不同站立稳定性水平下踝关节屈伸活动的表面肌电图分析。
IF 1.6 4区 医学 Pub Date : 2024-05-01 DOI: 10.1177/10225536241258336
Fangchao Wu, Jiahe Zhang, Kezhen Yang, Yangzhen Li, Zetong Li, Tian Li, Jianhua Li

Background: To observe the activation strategies of the ankle muscles using surface electromyography (sEMG) during single-leg standing (SLS) and both-leg standing (BLS) on flat ground (FG), soft mat (SM), and BOSU ball (BB) surfaces. Methods: Thirty healthy young adults participated in the study. The muscle activities of the tibialis anterior (TA) and gastrocnemius medial (GM) were measured on the three surfaces during SLS and BLS. Electromyographic evaluations of the TA and GM were recorded during maximum voluntary isometric contractions (MVIC). Muscle activation was evaluated using MVIC%, and muscle co-contraction was evaluated using the co-contraction index (CI). Results: A statistically significant increase was observed in the MVIC% of the TA, GM, and CI on the three surfaces during SLS compared to BLS, except for the comparison of CI on BB between SLS and BLS (t = -1.35, p = 0.19). The MVIC% of the TA and GM during SLS and BLS on BB was significantly increased in comparison with FG and SM. The CI during BLS on BB increased compared to FG (t = 3.19, p < 0.01) and SM (t = 4.64, p < 0.01). The CI during BLS on SM (t = -1.46, p = 0.15) decreased when compared to FG but without statistical significance. Conclusions: SLS and unstable surfaces can induce greater muscle activation, and SLS can have a greater influence on ankle muscles.

研究背景通过表面肌电图(sEMG)观察在平地(FG)、软垫(SM)和 BOSU 球(BB)表面进行单腿站立(SLS)和双腿站立(BLS)时踝关节肌肉的激活策略。研究方法30 名健康的年轻人参加了研究。在 SLS 和 BLS 过程中,在三种表面上测量了胫骨前肌(TA)和腓肠肌内侧(GM)的肌肉活动。在最大自主等长收缩(MVIC)过程中记录了胫骨前肌(TA)和腓肠肌内侧(GM)的肌电图评估。使用 MVIC% 评估肌肉激活情况,使用共收缩指数 (CI) 评估肌肉共收缩情况。结果:与 BLS 相比,除了 BB 上的 CI 在 SLS 和 BLS 之间的比较(t =-1.35,p = 0.19)外,在 SLS 期间观察到 TA、GM 和 CI 在三个表面上的 MVIC% 有统计学意义的明显增加。与 FG 和 SM 相比,SLS 和 BLS 期间 BB 上 TA 和 GM 的 MVIC% 明显增加。与 FG(t = 3.19,p < 0.01)和 SM(t = 4.64,p < 0.01)相比,BB 上 BLS 期间的 CI 增加了。与 FG 相比,SM(t =-1.46,p = 0.15)上 BLS 期间的 CI 有所下降,但无统计学意义。结论:SLS和不稳定表面可引起更大的肌肉激活,SLS对踝关节肌肉的影响更大。
{"title":"Surface electromyography analysis of ankle flexor and extensor activity under different standing stability levels.","authors":"Fangchao Wu, Jiahe Zhang, Kezhen Yang, Yangzhen Li, Zetong Li, Tian Li, Jianhua Li","doi":"10.1177/10225536241258336","DOIUrl":"https://doi.org/10.1177/10225536241258336","url":null,"abstract":"<p><p><b>Background:</b> To observe the activation strategies of the ankle muscles using surface electromyography (sEMG) during single-leg standing (SLS) and both-leg standing (BLS) on flat ground (FG), soft mat (SM), and BOSU ball (BB) surfaces. <b>Methods:</b> Thirty healthy young adults participated in the study. The muscle activities of the tibialis anterior (TA) and gastrocnemius medial (GM) were measured on the three surfaces during SLS and BLS. Electromyographic evaluations of the TA and GM were recorded during maximum voluntary isometric contractions (MVIC). Muscle activation was evaluated using MVIC%, and muscle co-contraction was evaluated using the co-contraction index (CI). <b>Results:</b> A statistically significant increase was observed in the MVIC% of the TA, GM, and CI on the three surfaces during SLS compared to BLS, except for the comparison of CI on BB between SLS and BLS (t = -1.35, <i>p</i> = 0.19). The MVIC% of the TA and GM during SLS and BLS on BB was significantly increased in comparison with FG and SM. The CI during BLS on BB increased compared to FG (t = 3.19, <i>p</i> < 0.01) and SM (t = 4.64, <i>p</i> < 0.01). The CI during BLS on SM (t = -1.46, <i>p</i> = 0.15) decreased when compared to FG but without statistical significance. <b>Conclusions:</b> SLS and unstable surfaces can induce greater muscle activation, and SLS can have a greater influence on ankle muscles.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"32 2","pages":"10225536241258336"},"PeriodicalIF":1.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Orthopaedic Surgery
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