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Outcome of a Fixed-Bearing all-polyethylene unicompartmental tibial tray: A 12-year Joint Registry Follow-Up study. 固定轴承全聚乙烯单间隙胫骨托盘的结果:一项为期12年的关节登记随访研究。
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-01-15 DOI: 10.1177/10225536261416586
Katarina Sim, Simon Hadlow

AimsThis study aims to evaluate the long-term durability of a unicompartmental knee arthroplasty (UKA) implant using a fixed-bearing all-polyethylene tibial tray with a Cobalt-Chromium (Co-Cr) femoral condyle, stratified by patient age. It also aims to compare implant survivorship between inlay and onlay tibial implantation techniques.MethodsData from the New Zealand Joint Registry (NZJR) was used to evaluate survival of Smith & Nephew Genesis II® UKA performed between February 2000 and December 2011 in which two different tibial implant techniques (inlay and onlay) were used. The primary endpoint was revision surgery.ResultsAt a minimum follow-up of 10 years, 57 revisions were performed at an average of 6.6 years from index surgery. The revision rate per 100 component years was 1.29 (CI: 0.97 - 1.66), with a significant difference between the over-75 years cohort compared with the under-65 cohort, in favour of the older cohort (p < 0.05). There was a significant difference in survival between inlay and onlay techniques, in favour of the inlay technique (p < 0.05).ConclusionFixed-bearing all-polyethylene tibial UKA show acceptable outcomes at an average 12-year follow-up, especially in elderly patients and use of inlay tibial tray implantation technique.

目的:本研究旨在评估单室膝关节置换术(UKA)植入物的长期耐久性,该植入物使用固定承载的全聚乙烯胫骨托盘和钴铬(Co-Cr)股骨髁,并根据患者年龄分层。它还旨在比较内嵌和纯胫骨植入技术之间的种植体存活率。方法采用新西兰联合注册中心(NZJR)的数据,评估2000年2月至2011年12月期间使用两种不同胫骨植入技术(嵌体和嵌体)进行的Smith & Nephew Genesis II®UKA的生存率。主要终点是翻修手术。结果在至少10年的随访中,从指数手术开始平均6.6年,进行了57次翻修。每100个组成年的修订率为1.29 (CI: 0.97 - 1.66), 75岁以上的队列与65岁以下的队列比较差异有统计学意义(p < 0.05)。嵌体与嵌体技术的生存率差异有统计学意义(p < 0.05)。结论在平均随访12年的情况下,固定轴承全聚乙烯胫骨UKA的效果可接受,特别是在老年患者和采用内嵌式胫骨托盘植入技术的情况下。
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引用次数: 0
Radiographic tibial tubercle morphology as a predictor of anterior cruciate ligament injury. 胫骨结节的影像学形态作为前交叉韧带损伤的预测因子。
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-01-20 DOI: 10.1177/10225536261419556
Muhammed Furkan Küçükşen, Onur Bilge, Haluk Yaka, Furkan Bülbül, Mehmet Demiryürek, Faik Türkmen, Fatih Tahak

PurposeFew studies have assessed the link between tibial tubercle (TT) morphology and anterior cruciate ligament (ACL) injury, and most focus only on the TT-trochlear groove (TT-TG) distance. This study aimed to examine the relationship between ACL injury, TT morphology, and posterior tibial slope (PTS) by comprehensively evaluating TT-related radiological parameters.MethodsRadiological images of 100 patients who underwent isolated ACL reconstruction for non-contact injury between 2016 and 2022 and 100 demographically matched controls with no relevant abnormalities on knee MRI were retrospectively analyzed. Thirteen radiological parameters were measured and compared, including PTS; TT torsion (TTT); TT-rotational angle (TT-RA); plateau axis-tuberosity axis (PA-TA); TT-TG; TT-PCL distance and ratio; TT lateralization (TTL) distance and ratio; TT height (TTH); and TT angle (TTA). Associations between these parameters and ACL injury, as well as interparameter correlations, were evaluated using t-tests, logistic regression, ROC analysis, and Pearson correlation.ResultsMean TTT, TT-RA and PA-TA values were significantly lower in the ACL injury group (5.68° vs 8.34°, p < .001; 7.96° vs 12.09°, p < .001; 8.41° vs 11.58°, p < .001). Conversely, TT-TG, PTS and TTH were higher (10.69 mm vs 8.17 mm, p < .001; 12.84° vs 10.61°, p < .001; 11.69 mm vs 10.02 mm, p < .001). Logistic regression showed TTT (OR = -0.849), TT-RA (OR = -0.822), TT-TG (OR = 1.298), PTS (OR = 1.177), and TTH (OR = 1.327) independently associated with ACL injury.ConclusionIn isolated ACL injury patients, TT torsion was lower and TT prominence higher. TT morphology assessment may help personalize ACL reconstruction, identify high-risk individuals, and support future clinical and biomechanical research on ACL injury susceptibility.

目的很少有研究评估胫骨结节(TT)形态与前交叉韧带(ACL)损伤之间的关系,大多数研究只关注TT-滑车沟(TT- tg)距离。本研究旨在通过综合评估与前交叉韧带相关的放射学参数,探讨前交叉韧带损伤、前交叉韧带形态与胫骨后坡(PTS)之间的关系。方法回顾性分析2016年至2022年间100例非接触性损伤行孤立前交叉韧带重建的患者和100例人口统计学匹配且膝关节MRI无相关异常的对照组的影像学图像。测量并比较13个放射学参数,包括PTS;TT扭量(TTT);tt -旋转角(TT-RA);高原轴-结节轴(PA-TA);TT-TG;TT-PCL距离和比值;TT侧化(TTL)距离和比值;TT高度(TTH);和TT角(TTA)。使用t检验、逻辑回归、ROC分析和Pearson相关来评估这些参数与ACL损伤之间的关联以及参数间的相关性。结果前交叉韧带损伤组TTT、TT-RA、PA-TA均值显著低于前交叉韧带损伤组(5.68°比8.34°,p < 0.001; 7.96°比12.09°,p < 0.001; 8.41°比11.58°,p < 0.001)。相反,TT-TG、PTS和TTH升高(10.69 mm比8.17 mm, p < 0.001; 12.84°比10.61°,p < 0.001; 11.69 mm比10.02 mm, p < 0.001)。Logistic回归显示TTT (OR = -0.849)、TT-RA (OR = -0.822)、TT-TG (OR = 1.298)、PTS (OR = 1.177)、TTH (OR = 1.327)与ACL损伤独立相关。结论孤立性前交叉韧带损伤患者TT扭转较低,TT显著性较高。TT形态学评估有助于ACL重建个体化,识别高危人群,并为未来ACL损伤易感性的临床和生物力学研究提供支持。
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引用次数: 0
Gastrocnemius recession in the treatment of isolated metatarsalgia: A systematic review of surgical outcomes and complications. 腓肠肌收缩治疗孤立性跖骨痛:手术结果和并发症的系统回顾。
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-01-24 DOI: 10.1177/10225536251350416
Sara Calori, Alessandro Giuliani, Guido Bocchino, Fabrizio Forconi, Giulio Maccauro, Raffaele Vitiello

Background: Metatarsalgia is a frequent cause of forefoot pain, often linked to isolated gastrocnemius tightness, which increases forefoot pressure during gait. Gastrocnemius recession has been proposed as a surgical treatment to correct this biomechanical dysfunction. This systematic review aims to evaluate the clinical outcomes, complication rates, and quality of evidence regarding gastrocnemius recession performed exclusively for the treatment of isolated metatarsalgia. Materials and Methods: A systematic search of PubMed, MEDLINE, and the Cochrane Library was conducted in February 2025 following PRISMA guidelines. Studies were included if they reported outcomes of gastrocnemius release performed solely for isolated metatarsalgia. Data on surgical techniques, clinical outcomes, complications, and follow-up durations were extracted and analyzed. Results: Three studies met the inclusion criteria, encompassing a total of 86 operated feet with a mean follow-up of 37.5 months. Surgical techniques varied across studies, including proximal medial gastrocnemius release and musculotendinous junction recession. All studies reported significant improvements in Visual Analogue Scale (VAS) scores, along with high rates of patient satisfaction. Nevertheless, approximately 30% of patients required adjunctive forefoot procedures. The complication rate was low and predominantly involved minor nerve symptoms and transient bruising. Conclusion: Gastrocnemius recession appears to be an effective and safe surgical option for the management of isolated metatarsalgia, providing substantial pain relief and high patient satisfaction. However, the multifactorial nature of metatarsalgia often necessitates additional forefoot procedures. Standardization of surgical techniques, postoperative protocols, and outcome measures is essential to enhance clinical decision-making and future research quality.

背景:跖骨痛是前脚疼痛的常见原因,通常与孤立的腓肠肌紧绷有关,这增加了步态时的前脚压力。腓肠肌后退已被建议作为一种外科治疗来纠正这种生物力学功能障碍。本系统综述旨在评估单独治疗跖骨痛的腓肠肌收缩的临床结果、并发症发生率和证据质量。材料和方法:根据PRISMA指南,于2025年2月对PubMed、MEDLINE和Cochrane图书馆进行了系统搜索。仅报道腓肠肌松解治疗孤立性跖骨痛的结果的研究被纳入。提取并分析手术技术、临床结果、并发症和随访时间的数据。结果:三项研究符合纳入标准,共涉及86例手术足,平均随访37.5个月。手术技术在不同的研究中有所不同,包括近端腓肠肌内侧松解和肌肉肌腱连接处收缩。所有研究都报告了视觉模拟量表(VAS)评分的显著改善,以及患者满意度的提高。然而,大约30%的患者需要辅助前足手术。并发症发生率低,主要涉及轻微神经症状和一过性瘀伤。结论:腓肠肌后退术是治疗孤立性跖骨痛的一种有效且安全的手术选择,可有效缓解疼痛,患者满意度高。然而,跖痛的多因素性质往往需要额外的前足手术。手术技术、术后方案和结果测量的标准化对于提高临床决策和未来研究质量至关重要。
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引用次数: 0
Double compression technique for first MTP joint fusion: A cadaveric analysis of valgus plate fixation. 双加压技术用于首次MTP关节融合:外翻钢板固定的尸体分析。
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-02-09 DOI: 10.1177/10225536251415444
Danny Deng, Rajat Mittal, Gavin Buzza, Joseph Cadman, Dane Dabirrahmani Turner, Richard Appleyard, Dean Pepper

IntroductionFirst metatarsophalangeal (MTP) joint arthrodesis is the gold-standard treatment for end-stage arthritis and hallux deformities. Successful fusion is improved by achieving adequate compression across the joint. Traditional plating systems provide single-point compression, whereas the Arthrex MTP valgus plate is designed for double compression, potentially improving stability and union rates. This study aimed to confirm double compression and compare two anchoring methods: K-wire and olive tip guide wire (BB-tack).MethodsTwelve cadaveric feet were randomised to plate fixation using either K-wire or BB-tack anchoring. Compression was measured with Tekscan sensors during three stages: after seating the first compression screw, after seating the second screw, and after reseating the second screw without the stabilising K-wire. Peak force and contact pressure were analysed using ANOVA and t-tests (α = 0.05).ResultsBoth techniques achieved measurable compression after the first screw, which increased significantly with the second screw (mean pressure: 0.55-0.62 MPa; peak force: 18.3-22.2 N). Removing the stabilising K-wire before reseating reduced peak force but maintained comparable pressure. No significant differences were found between anchoring methods (p > 0.05).ConclusionThe Arthrex MTP valgus plate achieves double compression, enhancing construct rigidity compared to single-compression systems. Further clinical studies are warranted to validate these biomechanical advantages.

第一跖趾(MTP)关节融合术是治疗终末期关节炎和拇趾畸形的金标准。通过在整个关节处实现足够的压缩,可以改善成功的融合。传统的电镀系统提供单点压缩,而Arthrex MTP外翻钢板设计用于双重压缩,可能提高稳定性和愈合率。本研究旨在确认双压缩,并比较两种锚定方法:k -丝和橄榄尖导丝(BB-tack)。方法随机选取12只尸体足,采用k -丝或bb -钉锚定钢板固定。通过Tekscan传感器测量了三个阶段的压缩情况:安装第一根压缩螺钉后,安装第二根螺钉后,在没有固定k线的情况下重新安装第二根螺钉后。峰值力和接触压力分析采用方差分析和t检验(α = 0.05)。结果两种方法在第一枚螺钉后均获得了可测量的压缩,在第二枚螺钉后压缩显著增加(平均压力:0.55-0.62 MPa;峰值力:18.3-22.2 N)。在重新安装前拆除稳定k型钢丝,降低了峰值压力,但保持了相当的压力。不同锚固方式间无显著差异(p < 0.05)。结论Arthrex MTP外翻钢板实现了双压迫,与单压迫系统相比,提高了结构刚度。需要进一步的临床研究来验证这些生物力学优势。
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引用次数: 0
A diagnostic model based on clinical indicators and radiomics features for superior labral anterior and posterior lesions in the shoulder joint. 基于临床指标和放射组学特征的上唇肩关节前后病变诊断模型。
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-01-25 DOI: 10.1177/10225536261418429
Hongyu Wang, Lin Wang, Lei Shi, Fei Wang, Guanghan Gao, Qingyun Xue

BackgroundSuperior labrum anterior and posterior (SLAP) lesions are a common cause of shoulder pain and instability. Accurate diagnosis remains challenging in clinical practice. This study aims to develop and evaluate radiomics models and combined models integrating radiomics and clinical features for SLAP lesion detection.MethodsThis retrospective study included 149 patients who underwent shoulder arthroscopic surgery with preoperative shoulder magnetic resonance imaging (MRI) between 2019 and 2024. Regions of interest (ROIs) were manually delineated on MRI oblique coronal proton density-weighted fat-suppressed (PD FS) images, and radiomics features were subsequently extracted from these defined regions. Feature selection employed independent t-tests, Mann-Whitney U tests, Pearson correlation analysis, and least absolute shrinkage and selection operator (LASSO) regression. Common machine learning models including Support Vector Machine (SVM), Random Forest (RF), and Light Gradient Boosting Machine (LightGBM) were employed to construct diagnostic models based on radiomics features. A combined model integrating radiomics and clinical features was developed and visualized using nomograms.ResultsIn the test cohort, the LightGBM-based radiomics model achieved optimal performance with the Area Under the Curve (AUC) of 0.867, sensitivity of 0.952, and specificity of 0.625. The combined model demonstrated enhanced diagnostic capability with AUC of 0.899, sensitivity of 0.762, and specificity of 0.917. Manual diagnosis of SLAP injury using MRI achieved an accuracy of 50.3%, with a sensitivity of 27.7%, specificity of 78.8%, and AUC of 0.619.ConclusionMachine learning models based on MRI radiomics features demonstrated superior diagnostic accuracy compared to traditional radiologist assessment for SLAP lesions. The combined model incorporating both radiomics and clinical features provides effective risk prediction for SLAP lesions.

背景:上唇前后(SLAP)病变是引起肩部疼痛和不稳定的常见原因。在临床实践中,准确诊断仍然具有挑战性。本研究旨在建立和评估用于SLAP病变检测的放射组学模型和结合放射组学与临床特征的联合模型。方法回顾性研究纳入2019年至2024年间接受肩关节镜手术并术前进行肩关节磁共振成像(MRI)的149例患者。在MRI斜冠状位质子密度加权脂肪抑制(PD FS)图像上手动划定感兴趣区域(roi),随后从这些定义区域提取放射组学特征。特征选择采用独立t检验、Mann-Whitney U检验、Pearson相关分析和最小绝对收缩和选择算子(LASSO)回归。采用支持向量机(SVM)、随机森林(RF)、光梯度增强机(LightGBM)等常用机器学习模型构建基于放射组学特征的诊断模型。结合放射组学和临床特征开发了一个组合模型,并使用图显示。结果在测试队列中,基于lightgbm的放射组学模型的曲线下面积(Area Under the Curve, AUC)为0.867,灵敏度为0.952,特异性为0.625。联合模型的诊断能力增强,AUC为0.899,灵敏度为0.762,特异性为0.917。MRI手工诊断SLAP损伤的准确率为50.3%,敏感性27.7%,特异性78.8%,AUC为0.619。结论基于MRI放射组学特征的机器学习模型与传统放射科医师评估相比,对SLAP病变的诊断准确性更高。结合放射组学和临床特征的联合模型为SLAP病变提供了有效的风险预测。
{"title":"A diagnostic model based on clinical indicators and radiomics features for superior labral anterior and posterior lesions in the shoulder joint.","authors":"Hongyu Wang, Lin Wang, Lei Shi, Fei Wang, Guanghan Gao, Qingyun Xue","doi":"10.1177/10225536261418429","DOIUrl":"https://doi.org/10.1177/10225536261418429","url":null,"abstract":"<p><p>BackgroundSuperior labrum anterior and posterior (SLAP) lesions are a common cause of shoulder pain and instability. Accurate diagnosis remains challenging in clinical practice. This study aims to develop and evaluate radiomics models and combined models integrating radiomics and clinical features for SLAP lesion detection.MethodsThis retrospective study included 149 patients who underwent shoulder arthroscopic surgery with preoperative shoulder magnetic resonance imaging (MRI) between 2019 and 2024. Regions of interest (ROIs) were manually delineated on MRI oblique coronal proton density-weighted fat-suppressed (PD FS) images, and radiomics features were subsequently extracted from these defined regions. Feature selection employed independent t-tests, Mann-Whitney U tests, Pearson correlation analysis, and least absolute shrinkage and selection operator (LASSO) regression. Common machine learning models including Support Vector Machine (SVM), Random Forest (RF), and Light Gradient Boosting Machine (LightGBM) were employed to construct diagnostic models based on radiomics features. A combined model integrating radiomics and clinical features was developed and visualized using nomograms.ResultsIn the test cohort, the LightGBM-based radiomics model achieved optimal performance with the Area Under the Curve (AUC) of 0.867, sensitivity of 0.952, and specificity of 0.625. The combined model demonstrated enhanced diagnostic capability with AUC of 0.899, sensitivity of 0.762, and specificity of 0.917. Manual diagnosis of SLAP injury using MRI achieved an accuracy of 50.3%, with a sensitivity of 27.7%, specificity of 78.8%, and AUC of 0.619.ConclusionMachine learning models based on MRI radiomics features demonstrated superior diagnostic accuracy compared to traditional radiologist assessment for SLAP lesions. The combined model incorporating both radiomics and clinical features provides effective risk prediction for SLAP lesions.</p>","PeriodicalId":16608,"journal":{"name":"Journal of Orthopaedic Surgery","volume":"34 1","pages":"10225536261418429"},"PeriodicalIF":1.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modified combined Woodward and Green procedure for adult congenital Sprengel deformity. 改良的Woodward和Green联合手术治疗成人先天性Sprengel畸形。
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI: 10.1177/10225536261418722
Feng Zhu, Wei Mei, Xiangjian Song

ObjectiveTo investigate the clinical efficacy and incidence of complications in the treatment of adult congenital high scapula (Sprengel deformity) using the modified combined Woodward and Green surgical approach.MethodsFrom January 2020 to January 2024, 9 adult patients with congenital Sprengel deformity were treated with the modified Woodward and Green combined procedure. There were two males and seven females, aged 18-35 years (mean: 23.5 ± 4.2 years), with 6 cases on the left and 3 on the right. The surgical procedure involved the modified combined Woodward and Green technique. Postoperatively, routine infection prevention, 4-weeks brace fixation, and rehabilitation guidance were performed. Shoulder appearance was evaluated using the Cavendish grading system; bilateral scapular height difference was measured; and shoulder function was assessed using the UCLA Shoulder Function Rating System, including pain, daily activity ability, range of motion, and muscle strength. Paired t-tests were used to analyze pre- and postoperative data with SPSS 22.0 software.ResultsAll 9 patients were followed up for 12-36 months (mean: 24.11 ± 6.63 months). Postoperatively, shoulder appearance significantly improved, with marked reduction in scapular position, good correction of elevation and shrugging deformities, and near-normal shoulder contour. Cavendish grading improved significantly (p < 0.05). The scapular height difference decreased from 4.50 ± 0.67 cm preoperatively to 0.89 ± 0.77 cm at the last follow-up, and the UCLA shoulder function score increased from 23.44 ± 1.57 to 30.33 ± 0.67, with statistically significant differences (p < 0.001 for both).ConclusionThe modified combined Woodward and Green procedure is a safe and effective treatment for adult congenital Sprengel deformity, significantly improving shoulder appearance and joint function. However, due to the small sample size and short follow-up period, future studies with larger samples and longer follow-ups are needed to accurately evaluate the long-term efficacy.

目的探讨改良Woodward - Green联合入路治疗成人先天性高肩胛骨(Sprengel畸形)的临床疗效及并发症发生率。方法自2020年1月至2024年1月,对9例成人先天性Sprengel畸形采用改良Woodward - Green联合手术治疗。男性2例,女性7例,年龄18 ~ 35岁(平均23.5±4.2岁),左侧6例,右侧3例。手术过程涉及改良的Woodward和Green联合技术。术后常规预防感染,4周支架固定及康复指导。采用卡文迪什评分系统对肩部外观进行评价;测量双侧肩胛骨高度差;使用UCLA肩功能评分系统评估肩部功能,包括疼痛、日常活动能力、活动范围和肌肉力量。采用SPSS 22.0软件对术前和术后数据进行配对t检验。结果9例患者均获得12 ~ 36个月的随访,平均24.11±6.63个月。术后肩部外观明显改善,肩胛骨位置明显降低,抬高和耸肩畸形矫正良好,肩部轮廓接近正常。卡文迪什评分显著提高(p < 0.05)。肩胛骨高度差由术前的4.50±0.67 cm降至末次随访时的0.89±0.77 cm, UCLA肩关节功能评分由23.44±1.57上升至30.33±0.67,差异均有统计学意义(p < 0.001)。结论改良的Woodward和Green联合手术治疗成人先天性Sprengel畸形安全有效,可显著改善肩部外观和关节功能。然而,由于样本量小,随访时间短,未来需要更大样本量和更长随访时间的研究来准确评估长期疗效。
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引用次数: 0
Denosumab treatment after percutaneous vertebroplasty for osteoporotic vertebral compression fractures: Long-term follow-up of pain relief, bone mineral density changes, and risk of refracture. 经皮椎体成形术后Denosumab治疗骨质疏松性椎体压缩性骨折:疼痛缓解、骨密度变化和再骨折风险的长期随访
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-01-13 DOI: 10.1177/10225536261417407
Qinglong Li, Huagang Shi, Xing Chen, Simao Song

ObjectiveTo investigate the effects of denosumab on pain relief, bone mineral density (BMD), and refracture risk during long-term follow-up in patients with osteoporotic vertebral compression fractures (OVCF) after percutaneous vertebroplasty, and to identify factors associated with refracture.MethodsThis retrospective study included 396 OVCF patients who underwent percutaneous vertebroplasty and received denosumab between January 2021 and June 2023. Patients were classified into a completed-treatment group (n = 184) and a discontinued-treatment group (n = 212). After 1:1 propensity score matching, 101 patients were included in each group. Changes in visual analog scale (VAS) scores and lumbar spine and femoral neck T-score were compared over 24 months. Refracture risk was assessed using Kaplan-Meier analysis and multivariable Cox regression in the matched cohort.ResultsAfter matching, baseline characteristics were well balanced between groups. Over 24 months of follow-up, the completed-treatment group showed significantly lower VAS scores and greater improvements in lumbar spine and femoral neck T-score compared with the discontinued-treatment group. The incidence of refracture was significantly lower in the completed-treatment group. In the PSM cohort, multivariable Cox regression analysis demonstrated that completed denosumab treatment was independently associated with a lower risk of refracture (HR = 0.314, 95% CI 0.125-0.792, P = 0.014).ConclusionIn patients with OVCF treated with percutaneous vertebroplasty, persistent denosumab therapy for at least 24 months is associated with sustained pain relief, improved BMD, and a lower risk of refracture, underscoring the importance of long-term treatment adherence.

目的探讨denosumab对骨质疏松性椎体压缩性骨折(OVCF)患者经皮椎体成形术后长期随访期间疼痛缓解、骨密度(BMD)和再骨折风险的影响,并探讨再骨折的相关因素。方法本回顾性研究纳入了396例OVCF患者,这些患者在2021年1月至2023年6月期间接受了经皮椎体成形术并接受了denosumab。将患者分为完成治疗组(184例)和停止治疗组(212例)。经1:1倾向评分匹配,每组101例。比较两组24个月内视觉模拟评分(VAS)、腰椎及股骨颈t评分的变化。在匹配队列中使用Kaplan-Meier分析和多变量Cox回归评估再骨折风险。结果组间基线特征匹配良好。在24个月的随访中,与停止治疗组相比,完成治疗组的VAS评分明显降低,腰椎和股骨颈t评分的改善更大。完全治疗组的再骨折发生率明显降低。在PSM队列中,多变量Cox回归分析显示,完成denosumab治疗与再骨折风险降低独立相关(HR = 0.314, 95% CI 0.125-0.792, P = 0.014)。结论在经皮椎体成形术治疗的OVCF患者中,持续地诺单抗治疗至少24个月与持续疼痛缓解、改善骨密度和降低再骨折风险相关,强调了长期治疗依从性的重要性。
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引用次数: 0
Predictive value of monocyte-to-albumin ratio, red cell distribution with-to-albumin ratio, hemoglobin-to-albumin ratio, leukocyte-to-albumin ratio, and platelet-to-albumin ratio for 14-day readmission following primary total knee arthroplasty. 单核细胞-白蛋白比、红细胞分布与白蛋白比、血红蛋白-白蛋白比、白细胞-白蛋白比和血小板-白蛋白比对初次全膝关节置换术后14天再入院的预测价值。
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-01-22 DOI: 10.1177/10225536261417467
Ngi-Chiong Lau, Ching-Wei Hu, Chih-Chien Hu, Yu-Yi Huang, Pin-Ren Huang, Dave W Chen

Total knee arthroplasty (TKA) is a frequently performed surgery for restoring function in patients with severe knee osteoarthritis. TKA is associated with significant healthcare costs, partly due to complications leading to readmissions. This study aimed to identify biomarkers predictive of readmission after TKA. Data of adult patients who underwent primary TKA between 2014 and 2022 extracted from the Chang Gung Medical Research Database were retrospectively reviewed. Associations between the monocyte-to-albumin ratio (MAR), red cell distribution with (RDW)-to-albumin ratio (RAR), hemoglobin-to-albumin ratio (HAR), leukocyte-to-albumin ratio (LAR), and platelet-to-albumin ratio (PAR) with 14-day readmission were determined using univariate and multivariable regression analyses. A score termed the 'MAR-LAR-PAR' score was developed using the combination of these 3 markers, and its prognostic value was assessed. Data from 1,137 patients were included. Elevated MAR (adjusted odds ratio [aOR] = 1.77, 95% confidence interval [CI]: 1.08-2.89, p = 0.022), LAR (aOR = 1.59, 95% CI: 1.02-2.45, p = 0.039), and PAR (aOR = 1.88, 95% CI: 1.12-3.15, p = 0.016) were significantly associated with increased risk of 14-day readmission. The highest MAR-LAR-PAR score (score = 3) was significantly associated with 14-day readmission compared to score = 0 (aOR = 4.24, 95% CI: 1.91-9.44, p < 0.001). This study highlights the potential of MAR, LAR, PAR, and the score based on their combination, as significant predictors of short-term readmission following TKA. Incorporating these biomarkers into preoperative assessment may help determine the risk of readmission, and provide additional care for these patients.

全膝关节置换术(TKA)是严重膝骨关节炎患者常用的恢复功能的手术。TKA与大量医疗费用相关,部分原因是并发症导致再入院。本研究旨在确定预测TKA后再入院的生物标志物。从长庚医学研究数据库中提取的2014年至2022年间接受原发性TKA的成年患者的数据进行回顾性分析。使用单变量和多变量回归分析确定14天再入院时单核细胞-白蛋白比(MAR)、红细胞分布(RDW)-白蛋白比(RAR)、血红蛋白-白蛋白比(HAR)、白细胞-白蛋白比(LAR)和血小板-白蛋白比(PAR)之间的关系。将这3种指标联合使用,形成“MAR-LAR-PAR”评分,并评估其预后价值。数据来自1137名患者。MAR(调整优势比[aOR] = 1.77, 95%可信区间[CI]: 1.08-2.89, p = 0.022)、LAR (aOR = 1.59, 95% CI: 1.02-2.45, p = 0.039)和PAR (aOR = 1.88, 95% CI: 1.12-3.15, p = 0.016)升高与14天再入院风险增加显著相关。与评分为0的患者相比,最高MAR-LAR-PAR评分(评分为3)与14天再入院显著相关(aOR = 4.24, 95% CI: 1.91-9.44, p < 0.001)。本研究强调了MAR、LAR、PAR和基于它们组合的评分作为TKA后短期再入院的重要预测指标的潜力。将这些生物标志物纳入术前评估可能有助于确定再入院的风险,并为这些患者提供额外的护理。
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引用次数: 0
Correlation between visceral adiposity index, body roundness index, lipid accumulation product and the risk and severity of knee osteoarthritis. 内脏脂肪指数、体圆度指数、脂质堆积积与膝骨关节炎风险及严重程度的相关性研究。
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-02-05 DOI: 10.1177/10225536261422525
Lilan Peng, Jing Yan, Yuquan Zhou, Qing He, Yunshan He, Niuxiu Li, Jianjun Zhou

ObjectiveThis study examined the associations of visceral adiposity index (VAI), body roundness index (BRI), and lipid accumulation product (LAP) with the risk, severity, and prognosis of knee osteoarthritis (KOA). The aim was to evaluate the clinical utility of these novel adiposity indices for early screening and prognostic assessment of KOA.MethodsA total of 124 patients with clinically and radiographically confirmed KOA and 120 healthy individuals who underwent routine physical examinations during the same period were enrolled as the KOA and control groups, respectively. Baseline data were collected retrospectively from electronic medical records. KOA patients were further classified into mild, moderate, and severe subgroups based on K-L grading and were followed for 12 months.ResultsCompared with controls, the KOA group had significantly higher BMI, TG, TC, LDL-C, VAI, BRI, and LAP, and lower HDL-C (p < 0.05). VAI, BRI, and LAP increased progressively with KOA severity (p < 0.05), showing positive correlations (r = 0.608, 0.489, 0.551, p < 0.001), and were confirmed as independent risk factors (p < 0.05). ROC analysis yielded AUCs of 0.775 (95% CI: 0.718-0.833; cutoff: 2.91) for VAI, 0.752 (95% CI: 0.692-0.813; cutoff: 5.21) for BRI, and 0.779 (95% CI: 0.722-0.836; cutoff: 48.58) for LAP, with a combined AUC of 0.880 (95% CI: 0.839-0.922). Survival time differed significantly across groups stratified by these cutoffs (VAI: χ2 = 4.238; BRI: χ2 = 3.956; LAP: χ2 = 6.043; all p < 0.05).ConclusionThis study concludes that VAI, BRI, and LAP are closely linked to KOA. Firstly, their levels are significantly raised in patients and show a positive correlation with disease severity, marking them as useful clinical indicators. Secondly, the combined detection of these indices provides superior predictive value for KOA and is associated with an unfavorable prognosis, suggesting their utility in comprehensive risk assessment.

目的探讨内脏脂肪指数(VAI)、体圆度指数(BRI)和脂质积累产物(LAP)与膝骨关节炎(KOA)的风险、严重程度和预后的关系。目的是评估这些新型肥胖指数在KOA早期筛查和预后评估中的临床应用。方法选取124例经临床及影像学证实的KOA患者和120例同期进行常规体检的健康人,分别作为KOA组和对照组。从电子病历中回顾性收集基线数据。根据K-L分级将KOA患者进一步分为轻度、中度和重度亚组,随访12个月。结果与对照组比较,KOA组患者BMI、TG、TC、LDL-C、VAI、BRI、LAP显著升高,HDL-C显著降低(p < 0.05)。VAI、BRI、LAP随KOA严重程度逐渐升高(p < 0.05),呈正相关(r = 0.608、0.489、0.551,p < 0.001),为独立危险因素(p < 0.05)。ROC分析得出,VAI的AUC为0.775 (95% CI: 0.718-0.833;截止日期:2.91),BRI的AUC为0.752 (95% CI: 0.692-0.813;截止日期:5.21),LAP的AUC为0.779 (95% CI: 0.722-0.836;截止日期:48.58),合并AUC为0.880 (95% CI: 0.839-0.922)。按这些截断点分层的各组生存时间差异显著(VAI: χ2 = 4.238; BRI: χ2 = 3.956; LAP: χ2 = 6.043;均p < 0.05)。结论VAI、BRI和LAP与KOA密切相关。首先,它们的水平在患者体内显著升高,并与疾病严重程度呈正相关,是有用的临床指标。其次,这些指标的联合检测对KOA的预测价值较高,但与不良预后相关,可用于综合风险评估。
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引用次数: 0
Effect of epidural patient-controlled analgesia on pain relief after lumbar spinal surgeries-a case-control study. 患者自控硬膜外镇痛对腰椎手术后疼痛缓解的影响——病例对照研究。
IF 1.6 4区 医学 Pub Date : 2026-01-01 Epub Date: 2026-01-07 DOI: 10.1177/10225536261415693
Hsin-Chang Chen, Jin-Huei Yu, Ming-Han Hsieh, Shih-Liang Shih

PurposePatients withspinal degenerative diseases are often older and have multiple comorbidities. This study aims to evaluate the impact of epidural patient-controlled analgesia (PCA) on postoperative pain relief in patients undergoing lumbar spine surgeries for spinal degenerative diseases.MethodsThis retrospective case-control study included patients who underwent lumbar spine surgeries for degenerative spinal stenosis, spondylolisthesis, herniated intervertebral discs, or osteoporotic spinal fractures with spinal stenosis. The PCA group consisted of patients who received 72-h epidural PCA for postoperative pain control, while the control group received standard postoperative pain management. All patients were allowed to request intramuscular rescue analgesics for additional pain control. The primary endpoint was defined as the mean visual analogue scale (VAS) score during the effective PCA period (postoperative day [POD] 1-3). Secondary endpoints included individual daily VAS scores, rebound pain, rescue analgesic injections, morphine consumption, drainage duration, drainage volume, length of hospital stay, and complications.ResultsA total of 209 patients (mean age 73.8 years) were included, with 88 patients in the PCA group and 121 in the control group. Mean VAS score across POD 1-3 was significantly lower in the PCA group (Cohen's d = -1.89, 95% CI = -2.22 to -1.56, p < 0.001). During hospitalization, the PCA group required significantly fewer rescue analgesic injections (Cohen's d = -2.47, 95% CI = -2.84 to -2.11) and less total morphine consumption (Cohen's d = -0.39, 95% CI = -0.67 to -0.11) compared to the control group. Although the PCA group experienced greater drainage volume and longer duration of drainage placement, the incidence of infection and the length of hospital stay were comparable between the two groups.ConclusionIn this real-world cohort of elderly patients with multiple comorbidities undergoing lumbar spinal surgery, epidural PCA provided effective pain relief without an observed increase in infection rates in this study population.

目的脊柱退行性疾病患者通常年龄较大,并伴有多种合并症。本研究旨在评估硬膜外患者自控镇痛(PCA)对腰椎退行性疾病手术患者术后疼痛缓解的影响。方法本回顾性病例对照研究纳入因退行性椎管狭窄、椎体滑脱、椎间盘突出或骨质疏松性椎管狭窄而行腰椎手术的患者。PCA组患者接受72小时硬膜外PCA进行术后疼痛控制,对照组患者接受标准的术后疼痛管理。所有患者均可要求肌内急救镇痛以进一步控制疼痛。主要终点定义为有效PCA期间(术后1-3天[POD])的平均视觉模拟评分(VAS)评分。次要终点包括个人每日VAS评分、反弹疼痛、抢救性镇痛注射、吗啡用量、引流时间、引流量、住院时间和并发症。结果共纳入209例患者,平均年龄73.8岁,其中PCA组88例,对照组121例。PCA组POD 1-3的VAS平均评分显著降低(Cohen’s d = -1.89, 95% CI = -2.22 ~ -1.56, p < 0.001)。在住院期间,与对照组相比,PCA组需要更少的抢救性镇痛注射(Cohen’s d = -2.47, 95% CI = -2.84 ~ -2.11)和更少的吗啡总用量(Cohen’s d = -0.39, 95% CI = -0.67 ~ -0.11)。虽然PCA组引流量更大,引流时间更长,但两组的感染发生率和住院时间相当。结论:在这个现实世界的队列中,有多种合并症的老年患者接受腰椎手术,硬膜外PCA提供了有效的疼痛缓解,而没有观察到感染率的增加。
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引用次数: 0
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Journal of Orthopaedic Surgery
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