Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139658
K. Kamaleshwaran, S. Natarajan, Anjali Malaikkal, Vyshakh Mohanan, A. Shinto
Cutaneous metastases from internal malignancies are rare with a reported incidence between 0.7% and 10%. It may be the first symptom in 7% of the patients with cancer. We report a case with distant solitary skin metastases in anterior abdominal skin from breast cancer detected on F-fluorodeoxyglucose-positron emission tomography/computed tomography imaging.
{"title":"Anterior abdominal wall cutaneous metastases detected by F-18 fluorodeoxyglucose-positron emission tomography/computed tomography in a patient with breast carcinoma","authors":"K. Kamaleshwaran, S. Natarajan, Anjali Malaikkal, Vyshakh Mohanan, A. Shinto","doi":"10.4103/2348-3113.139658","DOIUrl":"https://doi.org/10.4103/2348-3113.139658","url":null,"abstract":"Cutaneous metastases from internal malignancies are rare with a reported incidence between 0.7% and 10%. It may be the first symptom in 7% of the patients with cancer. We report a case with distant solitary skin metastases in anterior abdominal skin from breast cancer detected on F-fluorodeoxyglucose-positron emission tomography/computed tomography imaging.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115196755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139660
J. Sharma, C. Chonzik, Tonmoy Das, M. Krishnatreya
Appendicular tumors are rare, and lymphoma of the appendix is rarer. A 50-year-old female patient presented with vague abdominal discomfort and lump in the right iliac fossa. The diagnosis of diffuse large B-cell lymphoma was made after laparotomy and histopathological examination (HPE) supported by immunohistochemistry study. For appendicular neoplasms diagnosed postoperatively, including lymphoma, a meticulous grossing and HPE cannot be over emphasized. In case of wall thickening of >2.50-3 cm detected by the computed tomogram scan, the possibility of a neoplasm or lymphoma in particular should be included as the differential diagnosis irrespective of the clinical presentation.
{"title":"B-cell lymphoma of the appendix: A case report and review of literature","authors":"J. Sharma, C. Chonzik, Tonmoy Das, M. Krishnatreya","doi":"10.4103/2348-3113.139660","DOIUrl":"https://doi.org/10.4103/2348-3113.139660","url":null,"abstract":"Appendicular tumors are rare, and lymphoma of the appendix is rarer. A 50-year-old female patient presented with vague abdominal discomfort and lump in the right iliac fossa. The diagnosis of diffuse large B-cell lymphoma was made after laparotomy and histopathological examination (HPE) supported by immunohistochemistry study. For appendicular neoplasms diagnosed postoperatively, including lymphoma, a meticulous grossing and HPE cannot be over emphasized. In case of wall thickening of >2.50-3 cm detected by the computed tomogram scan, the possibility of a neoplasm or lymphoma in particular should be included as the differential diagnosis irrespective of the clinical presentation.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130015009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139638
Ashok K. Sharma, A. Hussain, D. Walia, S. Bansal
Rapunzel syndrome is a rare variant of trichobezoar where the long tail of accumulated hairs extends to the small intestine. Gastrotomy of a 7-year-old female child revealed a mass consisting of hairs and remains of threads that occupied the entire stomach extending up to the jejunum. This is a unique case report of Rapunzel syndrome with habit of eating threads in addition with hair. Treatment and psychological support of the mental as well as physical disorder is important for prevention of its recurrence.
{"title":"Trichobezoar and Rapunzel syndrome: A review","authors":"Ashok K. Sharma, A. Hussain, D. Walia, S. Bansal","doi":"10.4103/2348-3113.139638","DOIUrl":"https://doi.org/10.4103/2348-3113.139638","url":null,"abstract":"Rapunzel syndrome is a rare variant of trichobezoar where the long tail of accumulated hairs extends to the small intestine. Gastrotomy of a 7-year-old female child revealed a mass consisting of hairs and remains of threads that occupied the entire stomach extending up to the jejunum. This is a unique case report of Rapunzel syndrome with habit of eating threads in addition with hair. Treatment and psychological support of the mental as well as physical disorder is important for prevention of its recurrence.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124537289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139663
S. Senapati, S. Suklabaidya, S. Panda
Sir/Madam, Dogs are the most preferable companion animal in biomedical research, and this is mostly due to their anatomical and physiological similarity with humans. Studies on dogs have opened a significant opportunity for translational research. The information obtained from these studies has a positive impact on advancing both human and animal health care. Therefore, in advanced countries aggressive collaborative efforts are being made to harness the benefits of comparative oncology studies. Unfortunately, the Indian cancer research and veterinary science communities have grossly ignored this field. Highlighting these issues the summary of a talk presented at the last Veterinary Pathology Congress, Bhubaneswar, India (November 21‐23; 2013) and subsequent discussions are provided here.
{"title":"Scope of comparative oncology in India","authors":"S. Senapati, S. Suklabaidya, S. Panda","doi":"10.4103/2348-3113.139663","DOIUrl":"https://doi.org/10.4103/2348-3113.139663","url":null,"abstract":"Sir/Madam, Dogs are the most preferable companion animal in biomedical research, and this is mostly due to their anatomical and physiological similarity with humans. Studies on dogs have opened a significant opportunity for translational research. The information obtained from these studies has a positive impact on advancing both human and animal health care. Therefore, in advanced countries aggressive collaborative efforts are being made to harness the benefits of comparative oncology studies. Unfortunately, the Indian cancer research and veterinary science communities have grossly ignored this field. Highlighting these issues the summary of a talk presented at the last Veterinary Pathology Congress, Bhubaneswar, India (November 21‐23; 2013) and subsequent discussions are provided here.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116360158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139651
A. Bansal, F. Siraj, S. Grover, A. Bhatnagar, S. Saxena
Mesenteric cavernous lymphangioma is a rare benign tumor, not often described in literature. The etiopathogenesis of this tumor is largely unknown. Clinically, the presentation is variable and may be asymptomatic or present with subacute or acute abdomen. We describe here a case of 23-year-old pregnant woman with an asymptomatic abdominal mass which was incidentally detected after ultrasound examination during antenatal visit. The pregnancy was subsequently terminated and the patient underwent surgical excision of the tumor along with intestinal resection. The mass was pathologically diagnosed to be mesenteric cavernous lymphangioma.
{"title":"Mesenteric lymphangioma: A rare intraabdominal finding in a pregnant woman","authors":"A. Bansal, F. Siraj, S. Grover, A. Bhatnagar, S. Saxena","doi":"10.4103/2348-3113.139651","DOIUrl":"https://doi.org/10.4103/2348-3113.139651","url":null,"abstract":"Mesenteric cavernous lymphangioma is a rare benign tumor, not often described in literature. The etiopathogenesis of this tumor is largely unknown. Clinically, the presentation is variable and may be asymptomatic or present with subacute or acute abdomen. We describe here a case of 23-year-old pregnant woman with an asymptomatic abdominal mass which was incidentally detected after ultrasound examination during antenatal visit. The pregnancy was subsequently terminated and the patient underwent surgical excision of the tumor along with intestinal resection. The mass was pathologically diagnosed to be mesenteric cavernous lymphangioma.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132377368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139621
R. Patnayak, V. Reddy, A. Jena, N. Rukmangadha, S. Parthasarathy, M. Reddy
Background: Helicobacter pylori is the causative organism for chronic active gastritis, duodenal ulcer and also for malignancies like gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma. It is essential to mention the presence of H. pylori in gastric biopsies as it has an important role in patient care. Though there are several special stains to detect H. pylori in histological sections, their specificity and sensitivity vary greatly. Immunohistochemically H. pylori can be detected by using anti H. pylori antibody, which reacts with somatic antigens of the whole bacteria. The aim of this study was to compare the reliability of routine hematoxylin and eosin (H and E), Giemsa, Warthin-Starry (WS) silver stain and immunohistochemical technique in diagnosing H. pylori. Materials and Methods: In this retrospective 1-year (2009) study, endoscopic gastric biopsies taken from patients during gastrointestinal-endoscopy with histopathological diagnosis of gastritis were studied. Standard H and E staining was performed on 5-μm-sections from paraffin block of each specimen. Microscopic sections of biopsy specimens of patients showing features of gastritis histopathologically in routine H and E stain and where the presence of H. pylori was suspected were also stained with Giemsa, WS, and immunohistochemistry (IHC) using purified polyclonal H. pylori antiserum (BioGenex). We have not included gastric resection specimens in our study. Results: Of the 29 cases, 26 (32.9%) showed presence of H. pylori on H and E, Giemsa and WS stains, whereas 49 (62.0%) cases demonstrated H. pylori on IHC stain. Conclusion: We conclude that H. pylori detection by IHC has advantage over routine H and E staining. However, in the developing countries with financial constraints, routine H and E staining in combination with special staining are fairly reliable in demonstrating H. pylori.
{"title":"Utility of immunohistochemistry in demonstrating Helicobacter pylori","authors":"R. Patnayak, V. Reddy, A. Jena, N. Rukmangadha, S. Parthasarathy, M. Reddy","doi":"10.4103/2348-3113.139621","DOIUrl":"https://doi.org/10.4103/2348-3113.139621","url":null,"abstract":"Background: Helicobacter pylori is the causative organism for chronic active gastritis, duodenal ulcer and also for malignancies like gastric adenocarcinoma and mucosa associated lymphoid tissue lymphoma. It is essential to mention the presence of H. pylori in gastric biopsies as it has an important role in patient care. Though there are several special stains to detect H. pylori in histological sections, their specificity and sensitivity vary greatly. Immunohistochemically H. pylori can be detected by using anti H. pylori antibody, which reacts with somatic antigens of the whole bacteria. The aim of this study was to compare the reliability of routine hematoxylin and eosin (H and E), Giemsa, Warthin-Starry (WS) silver stain and immunohistochemical technique in diagnosing H. pylori. Materials and Methods: In this retrospective 1-year (2009) study, endoscopic gastric biopsies taken from patients during gastrointestinal-endoscopy with histopathological diagnosis of gastritis were studied. Standard H and E staining was performed on 5-μm-sections from paraffin block of each specimen. Microscopic sections of biopsy specimens of patients showing features of gastritis histopathologically in routine H and E stain and where the presence of H. pylori was suspected were also stained with Giemsa, WS, and immunohistochemistry (IHC) using purified polyclonal H. pylori antiserum (BioGenex). We have not included gastric resection specimens in our study. Results: Of the 29 cases, 26 (32.9%) showed presence of H. pylori on H and E, Giemsa and WS stains, whereas 49 (62.0%) cases demonstrated H. pylori on IHC stain. Conclusion: We conclude that H. pylori detection by IHC has advantage over routine H and E staining. However, in the developing countries with financial constraints, routine H and E staining in combination with special staining are fairly reliable in demonstrating H. pylori.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122034749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139631
A. Jha, D. Banerjee, V. Bohra
Wilson′s disease (WD) is an autosomal recessive disorder of copper metabolism and regulation in the body, which presents with varied clinical symptoms commonly referable to hepatology (cirrhosis), neurology (dyskinesia and movement disorders), and psychiatry (abnormal behavior). The other systems, which may be involved, are endocrine (hypoparathyroidism), musculoskeletal (osteomalacia) and the genito-reproductive system (miscarriages and still births). We present a case, which was diagnosed as WD during evaluation of primary infertility and subsequently conceived after therapy with zinc.
Wilson 's disease (WD)是一种体内铜代谢和调节的常染色体隐性遗传病，临床症状多样，通常涉及肝病(肝硬化)、神经病学(运动障碍和运动障碍)和精神病学(异常行为)。其他可能涉及的系统包括内分泌系统(甲状旁腺功能减退)、肌肉骨骼系统(骨软化症)和生殖系统(流产和死产)。我们提出了一个病例，在评估原发性不孕症时被诊断为WD，随后在锌治疗后怀孕。
{"title":"Infertility and de-liver","authors":"A. Jha, D. Banerjee, V. Bohra","doi":"10.4103/2348-3113.139631","DOIUrl":"https://doi.org/10.4103/2348-3113.139631","url":null,"abstract":"Wilson′s disease (WD) is an autosomal recessive disorder of copper metabolism and regulation in the body, which presents with varied clinical symptoms commonly referable to hepatology (cirrhosis), neurology (dyskinesia and movement disorders), and psychiatry (abnormal behavior). The other systems, which may be involved, are endocrine (hypoparathyroidism), musculoskeletal (osteomalacia) and the genito-reproductive system (miscarriages and still births). We present a case, which was diagnosed as WD during evaluation of primary infertility and subsequently conceived after therapy with zinc.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131211767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139656
K. Kumar, Ganthimathy Sekhar, C. Srinivasan, Jayaganesh Parthasarathy
An unusual case of a 34-year-old woman with a malignant peripheral nerve sheath tumor (MPNST) associated with neurofibromatosis type 1 (NF1), arising from plexiform neurofibroma of the mesentery is presented here. She presented with complaints of abdominal pain of 10 days duration. Imaging revealed the presence of multiple nodules along with a large mass in the mesentery of the small bowel. Small bowel resection along with the mesenteric mass was done and histopathologic examination showed MPNST arising from a plexiform neurofibroma of the mesentery. A review of the literature showed that till date only three cases of MPNST arising from neurofibroma of the mesentery in NF1 patients have been reported out of which one was from a plexiform neurofibroma.
{"title":"Malignant peripheral nerve sheath tumor arising from plexiform neurofibroma of the mesentery in a patient with neurofibromatosis 1","authors":"K. Kumar, Ganthimathy Sekhar, C. Srinivasan, Jayaganesh Parthasarathy","doi":"10.4103/2348-3113.139656","DOIUrl":"https://doi.org/10.4103/2348-3113.139656","url":null,"abstract":"An unusual case of a 34-year-old woman with a malignant peripheral nerve sheath tumor (MPNST) associated with neurofibromatosis type 1 (NF1), arising from plexiform neurofibroma of the mesentery is presented here. She presented with complaints of abdominal pain of 10 days duration. Imaging revealed the presence of multiple nodules along with a large mass in the mesentery of the small bowel. Small bowel resection along with the mesenteric mass was done and histopathologic examination showed MPNST arising from a plexiform neurofibroma of the mesentery. A review of the literature showed that till date only three cases of MPNST arising from neurofibroma of the mesentery in NF1 patients have been reported out of which one was from a plexiform neurofibroma.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114252509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139636
Biswaranjan Nayak, Rashmi Dash, B. Mallik
Meckel′s diverticulum is present on the antimesentric border of the terminal ileum, within 2 ft proximal to the ileocecal valve, and results from incomplete closure of the vitello-intestinal duct. Meckel′s diverticulum is usually diagnosed during laparotomy or due to a complication of it such as bleeding, diverticulitis, and perforation. Tumors within Meckel′s diverticulum are a rare, but known complication. A 50-year-old male presented with fever and pain abdomen particularly in periumbilical region with sign of peritonitis. During laparotomy, a perforated Meckel′s diverticulum was found. A perforation was found at the apex of Meckel′s diverticulum. We resected 5 cm of the healthy bowel each side with primary anastomosis. Histopathology and immune-histochemistry shows gastrointestinal stromal tumors (GISTs) of Meckel′s diverticulum. GISTs arising from Meckel′s diverticulum are an extremely rare, but recognized complication. Surgery is the standard treatment for nonmetastatic GISTs with en bloc resection and clear margins.
{"title":"Perforated Meckel′s diverticulum as a result of gastrointestinal stromal tumor presenting as acute abdomen: A rare case report","authors":"Biswaranjan Nayak, Rashmi Dash, B. Mallik","doi":"10.4103/2348-3113.139636","DOIUrl":"https://doi.org/10.4103/2348-3113.139636","url":null,"abstract":"Meckel′s diverticulum is present on the antimesentric border of the terminal ileum, within 2 ft proximal to the ileocecal valve, and results from incomplete closure of the vitello-intestinal duct. Meckel′s diverticulum is usually diagnosed during laparotomy or due to a complication of it such as bleeding, diverticulitis, and perforation. Tumors within Meckel′s diverticulum are a rare, but known complication. A 50-year-old male presented with fever and pain abdomen particularly in periumbilical region with sign of peritonitis. During laparotomy, a perforated Meckel′s diverticulum was found. A perforation was found at the apex of Meckel′s diverticulum. We resected 5 cm of the healthy bowel each side with primary anastomosis. Histopathology and immune-histochemistry shows gastrointestinal stromal tumors (GISTs) of Meckel′s diverticulum. GISTs arising from Meckel′s diverticulum are an extremely rare, but recognized complication. Surgery is the standard treatment for nonmetastatic GISTs with en bloc resection and clear margins.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116951130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139647
R. Kalra, S. Garg, Sunita Singh, A. Batra, S. Chhabra
Familial adenomatous polyposis (FAP) is an autosomal dominant condition that results in development of the large number of colorectal, and eventually, small intestinal or even gastric adenomas at an early age (late childhood to early adulthood). Extragonadal yolk sac tumors (YSTs) of the gastrointestinal tract are extremely rare neoplasms. Their greater rarity compared with other extragonadal YSTs suggests that different pathogenetic mechanisms could be involved according to the site of origin. Recent epigenetic studies suggest the involvement of some tumor suppressor genes, including the adenomatous polyposis coli gene in testicular YST. No case has so far been described in setting of FAP. Hereby, we describe a case of extragonadal germ cell tumor arising in colectomy stump of a patient with FAP.
{"title":"Extragonadal germ cell tumor (yolk sac tumor) arising in a case of familial adenomatous polyposis","authors":"R. Kalra, S. Garg, Sunita Singh, A. Batra, S. Chhabra","doi":"10.4103/2348-3113.139647","DOIUrl":"https://doi.org/10.4103/2348-3113.139647","url":null,"abstract":"Familial adenomatous polyposis (FAP) is an autosomal dominant condition that results in development of the large number of colorectal, and eventually, small intestinal or even gastric adenomas at an early age (late childhood to early adulthood). Extragonadal yolk sac tumors (YSTs) of the gastrointestinal tract are extremely rare neoplasms. Their greater rarity compared with other extragonadal YSTs suggests that different pathogenetic mechanisms could be involved according to the site of origin. Recent epigenetic studies suggest the involvement of some tumor suppressor genes, including the adenomatous polyposis coli gene in testicular YST. No case has so far been described in setting of FAP. Hereby, we describe a case of extragonadal germ cell tumor arising in colectomy stump of a patient with FAP.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131505618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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