Pub Date : 2015-07-01DOI: 10.4103/2348-3113.152336
Sinai Siddhi Gaurish, J. Avinash, M. Kulkarni, D. Patel, A. Zode
{"title":"A rare case of monophasic synovial sarcoma of the hand: Cytological and immunohistopathological study","authors":"Sinai Siddhi Gaurish, J. Avinash, M. Kulkarni, D. Patel, A. Zode","doi":"10.4103/2348-3113.152336","DOIUrl":"https://doi.org/10.4103/2348-3113.152336","url":null,"abstract":"","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"229 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116253418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.4103/2348-3113.152334
C. Philips, C. Kalal, Amrish Sahney, K. Kumar
Stevens-Johnson Syndrome (SJS) forms part of a spectrum of severe adverse cutaneous reactions that can eventually culminate into toxic epidermal necrolysis (TEN), a potentially fatal condition. Drugs, most commonly allopurinol, antivirals, antiepileptics, sulfonamides and other antibiotics are implicated in this disease, even though, many case reports and series describe a variety of associations with many other classes of drugs. Infectious and inflammatory conditions also predispose to this severe cutaneous disease. Here, we present a patient who was initially diagnosed as a case of acute on chronic liver failure in hepatic encephalopathy grade I, in whom the introduction of rifaximin therapy led to aggressive cutaneous reactions, leading to SJS, which was managed with intensive supportive treatment because of which the patient improved substantially and was discharged after 14 days of onset of a potentially fatal condition. Rifaximin therapy leading to SJS-TEN has been reported only once before.
{"title":"Rifaximin induced Stevens-Johnson syndrome in a patient of acute on chronic liver failure","authors":"C. Philips, C. Kalal, Amrish Sahney, K. Kumar","doi":"10.4103/2348-3113.152334","DOIUrl":"https://doi.org/10.4103/2348-3113.152334","url":null,"abstract":"Stevens-Johnson Syndrome (SJS) forms part of a spectrum of severe adverse cutaneous reactions that can eventually culminate into toxic epidermal necrolysis (TEN), a potentially fatal condition. Drugs, most commonly allopurinol, antivirals, antiepileptics, sulfonamides and other antibiotics are implicated in this disease, even though, many case reports and series describe a variety of associations with many other classes of drugs. Infectious and inflammatory conditions also predispose to this severe cutaneous disease. Here, we present a patient who was initially diagnosed as a case of acute on chronic liver failure in hepatic encephalopathy grade I, in whom the introduction of rifaximin therapy led to aggressive cutaneous reactions, leading to SJS, which was managed with intensive supportive treatment because of which the patient improved substantially and was discharged after 14 days of onset of a potentially fatal condition. Rifaximin therapy leading to SJS-TEN has been reported only once before.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125518483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.4103/2348-3113.152319
Anuradha G. Patil, Shabnam Karangadan, S. Andola
Context: Serrated adenocarcinoma (SAC) is a recently described, distinct variant of colorectal carcinoma (CRC), accounting for about 7.5% of all CRCs and up to 17.5% of most proximal CRCs. It arises by serrated pathway characterized by early involvement of oncogenic BRAF mutations, excess CpG island methylation and subsequent low- or high-level DNA microsatellite instability and has a poorer prognosis than conventional colorectal carcinoma. Aims: The present study is an attempt to review and reclassify colorectal carcinomas into serrated and nonserrated type, and finds its incidence and associated features. Materials and Methods: Totally, 81 histopathologically diagnosed colorectal carcinomas during the period of 2001-2008 were reviewed. Histopathological criteria by Tuppurainen et al. was used to identify SAC and its features were studied. Results: Out of the total 81 cases of colorectal carcinoma comprising of mainly adenocarcinoma (81.48%), 5 cases of SAC were identified giving an incidence of 6.17%. Female preponderance (60%) was noted with mean age of 61.8 years. Most cases were located in cecum (60%). Serrated growth pattern was most frequent, noted in 60% cases, followed by mucinous in 20% and trabecular in 20%. Serrated mucinous carcinoma case also showed the presence of papillary rods, cell balls, focal clear cell change, and intraluminal dirty necrosis. Conclusion: This study attempts to define serrated colorectal adenocarcinoma in Indian population, where it has rarely been studied, using Tuppurainen et al.′s criteria. Since it is associated with poor prognosis its recognition, it is important for appropriate follow-up and therapeutic intervention.
{"title":"Serrated adenocarcinoma: A new look into colorectal carcinoma in Indian population","authors":"Anuradha G. Patil, Shabnam Karangadan, S. Andola","doi":"10.4103/2348-3113.152319","DOIUrl":"https://doi.org/10.4103/2348-3113.152319","url":null,"abstract":"Context: Serrated adenocarcinoma (SAC) is a recently described, distinct variant of colorectal carcinoma (CRC), accounting for about 7.5% of all CRCs and up to 17.5% of most proximal CRCs. It arises by serrated pathway characterized by early involvement of oncogenic BRAF mutations, excess CpG island methylation and subsequent low- or high-level DNA microsatellite instability and has a poorer prognosis than conventional colorectal carcinoma. Aims: The present study is an attempt to review and reclassify colorectal carcinomas into serrated and nonserrated type, and finds its incidence and associated features. Materials and Methods: Totally, 81 histopathologically diagnosed colorectal carcinomas during the period of 2001-2008 were reviewed. Histopathological criteria by Tuppurainen et al. was used to identify SAC and its features were studied. Results: Out of the total 81 cases of colorectal carcinoma comprising of mainly adenocarcinoma (81.48%), 5 cases of SAC were identified giving an incidence of 6.17%. Female preponderance (60%) was noted with mean age of 61.8 years. Most cases were located in cecum (60%). Serrated growth pattern was most frequent, noted in 60% cases, followed by mucinous in 20% and trabecular in 20%. Serrated mucinous carcinoma case also showed the presence of papillary rods, cell balls, focal clear cell change, and intraluminal dirty necrosis. Conclusion: This study attempts to define serrated colorectal adenocarcinoma in Indian population, where it has rarely been studied, using Tuppurainen et al.′s criteria. Since it is associated with poor prognosis its recognition, it is important for appropriate follow-up and therapeutic intervention.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130385779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.4103/2348-3113.152333
P. Aggarwal, G. Aggarwal
Buschke-Lowenstein tumor (BLT), also known as giant condyloma accuminata, first described in 1896 by Buschke, is a rare, slow-growing, locally invasive, mass lesion commonly affecting the anogenital region in immunocompromised males. This florid type of verrucous carcinoma is known for its high rate of recurrence as well as malignant conversion to squamous cell carcinoma. BLTs have been commonly reported to involve the penis, scrotum, bladder, vulva and perianal or anorectal regions. Our index case remains distinguished on the account of the rare anatomical location, causing a diagnostic dilemma, and once diagnosed managed adequately via surgery alone.
{"title":"Buschke-Lowenstein tumor of the inguinal region: A rare entity in a rarer location","authors":"P. Aggarwal, G. Aggarwal","doi":"10.4103/2348-3113.152333","DOIUrl":"https://doi.org/10.4103/2348-3113.152333","url":null,"abstract":"Buschke-Lowenstein tumor (BLT), also known as giant condyloma accuminata, first described in 1896 by Buschke, is a rare, slow-growing, locally invasive, mass lesion commonly affecting the anogenital region in immunocompromised males. This florid type of verrucous carcinoma is known for its high rate of recurrence as well as malignant conversion to squamous cell carcinoma. BLTs have been commonly reported to involve the penis, scrotum, bladder, vulva and perianal or anorectal regions. Our index case remains distinguished on the account of the rare anatomical location, causing a diagnostic dilemma, and once diagnosed managed adequately via surgery alone.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114129160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-07-01DOI: 10.4103/2348-3113.152330
S. Saraf, M. Chaturvedi, Manisha S Khare, A. Kalgutkar
Undifferentiated carcinoma is rare tumors with the worst prognosis than any type of surface epithelial carcinoma. They are common in fourth and fifth decade. In most cases, these spread beyond the ovary at the time of diagnosis and cannot be optimally debulked. A 17 years unmarried girl presented with an ovarian tumor, which on ultrasonography measured 9.9 cm Χ 6.7 cm Χ 6.6 cm arising from the left ovary and extending into the pelvis. Right ovary and other organs were unremarkable. Lab investigations: S. alpha fetoprotein (S.AFP) - 0.85 (0.5-2 ng/ml), B - human chorionic gonadotropin - 1.2 (<5 mIU/ml), cancer antigen - 125-127 (35 units/ml), carcinoembryonic antigen - 3.26 (<2.5 ng/ml). At histology, the tumor had undergone extensive areas of necrosis. The focal viable areas showed a poorly differentiated aggressive tumor. Extensive inter-observer variability in diagnosis existed. S.AFP levels were normal. AE1/AE3, EMA were positive while the rest IHC markers did not contribute to any specific diagnosis. The tumor was then diagnosed as undifferentiated carcinoma of the ovary. She received 3 cycles of cisplatin-based chemotherapy postoperatively. Two months later, she developed a metastatic nodule near the umbilicus. She succumbed to her illness within 3 months of diagnosis.
{"title":"A rare presentation of a necrotic undifferentiated ovarian carcinoma in an adolescent girl causing a diagnostic dilemma","authors":"S. Saraf, M. Chaturvedi, Manisha S Khare, A. Kalgutkar","doi":"10.4103/2348-3113.152330","DOIUrl":"https://doi.org/10.4103/2348-3113.152330","url":null,"abstract":"Undifferentiated carcinoma is rare tumors with the worst prognosis than any type of surface epithelial carcinoma. They are common in fourth and fifth decade. In most cases, these spread beyond the ovary at the time of diagnosis and cannot be optimally debulked. A 17 years unmarried girl presented with an ovarian tumor, which on ultrasonography measured 9.9 cm Χ 6.7 cm Χ 6.6 cm arising from the left ovary and extending into the pelvis. Right ovary and other organs were unremarkable. Lab investigations: S. alpha fetoprotein (S.AFP) - 0.85 (0.5-2 ng/ml), B - human chorionic gonadotropin - 1.2 (<5 mIU/ml), cancer antigen - 125-127 (35 units/ml), carcinoembryonic antigen - 3.26 (<2.5 ng/ml). At histology, the tumor had undergone extensive areas of necrosis. The focal viable areas showed a poorly differentiated aggressive tumor. Extensive inter-observer variability in diagnosis existed. S.AFP levels were normal. AE1/AE3, EMA were positive while the rest IHC markers did not contribute to any specific diagnosis. The tumor was then diagnosed as undifferentiated carcinoma of the ovary. She received 3 cycles of cisplatin-based chemotherapy postoperatively. Two months later, she developed a metastatic nodule near the umbilicus. She succumbed to her illness within 3 months of diagnosis.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"172 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123182542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-02-01DOI: 10.4103/2348-3113.152328
Y. Kadian
The vitellointestinal duct (VID) connects the yolksac to the midgut in the developing embryo and disappears by gestational week 9, just before the midgut returns to the abdomen. Failure of involution of the vitelline duct results in various residual structures like Meckel′s diverticulum, vitelline cord, enteric cyst, umbilical sinus, patent VID with ileal intussusception prolapsing over the umbilicus. The most common reported anomaly of residual vitelline duct is Meckel′s diverticulum with different presentations like bleeding, intestinal obstruction or diverticulitis. However, the patent VID with inverted ileal loop prolapse is a rarely reported. We have encountered three patients of this rare presentation who were managed successfully.
{"title":"Patent vitellointestinal duct with inverted ileal loop prolapse: A rare presentation","authors":"Y. Kadian","doi":"10.4103/2348-3113.152328","DOIUrl":"https://doi.org/10.4103/2348-3113.152328","url":null,"abstract":"The vitellointestinal duct (VID) connects the yolksac to the midgut in the developing embryo and disappears by gestational week 9, just before the midgut returns to the abdomen. Failure of involution of the vitelline duct results in various residual structures like Meckel′s diverticulum, vitelline cord, enteric cyst, umbilical sinus, patent VID with ileal intussusception prolapsing over the umbilicus. The most common reported anomaly of residual vitelline duct is Meckel′s diverticulum with different presentations like bleeding, intestinal obstruction or diverticulitis. However, the patent VID with inverted ileal loop prolapse is a rarely reported. We have encountered three patients of this rare presentation who were managed successfully.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115362273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139655
M. Garg, Gurmeen Kaur, N. Mahajan, S. Goyal
The deposition of amyloid as a distinct, clinically apparent mass is uncommon particularly in the soft tissues. There have been no previously published case reports of abdominal wall involvement; thereby we are describing a case of AA amyloidoma which presented as an abdominal wall abscess without any evidence of systemic disease. The clinical and radiological findings suggested soft tissue abscess likely cysticercosis or a neoplastic process. This case demonstrates the importance of considering the possibility of amyloidoma in the differential diagnosis of soft tissue lesions.
{"title":"Primary localized amyloidoma of abdominal wall presenting as abscess: Rare case","authors":"M. Garg, Gurmeen Kaur, N. Mahajan, S. Goyal","doi":"10.4103/2348-3113.139655","DOIUrl":"https://doi.org/10.4103/2348-3113.139655","url":null,"abstract":"The deposition of amyloid as a distinct, clinically apparent mass is uncommon particularly in the soft tissues. There have been no previously published case reports of abdominal wall involvement; thereby we are describing a case of AA amyloidoma which presented as an abdominal wall abscess without any evidence of systemic disease. The clinical and radiological findings suggested soft tissue abscess likely cysticercosis or a neoplastic process. This case demonstrates the importance of considering the possibility of amyloidoma in the differential diagnosis of soft tissue lesions.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123840697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139620
K. Kannan, P. Eswaran, S. Ismail
Objective: Gestational trophoblastic disease (GTD) is a peculiar disease in females of reproductive age group because of their natural history, management, high potential for bleeding and excellent response to chemotherapy. Although the incidence of brain metastases is only 10%, propensity for uncontrollable hemorrhage in brain parenchyma makes this situation, a medical emergency. We discuss case series of 7 patients with high risk GTD with brain metastases and their management. Study Design: A retrospective analysis of 15 years from January 1996 to December 2010 was done to study all cases of GTD treated in this institution. Patients who presented with brain metastases on initial diagnosis (early group) and who had metachronous disease (late group) during the course of treatment or follow-up were summarized in this study. Materials and Methods: Of 1208 cases of hydatidiform mole treated in this institution, 325 cases had low risk (WHO score 6 or less), and 38 patients had metastatic disease (score 7 and more). Seven cases were diagnosed to have a high risk GTD with brain metastases, 5 (71.43%) presented initially and 2 (28.57%) developed late brain metastases. Results: In our analysis, patients who had brain metastases on presentation had better survival (median = 52 months, range = 18-61) compared with patients who developed brain disease later in the course (median = 5.5 months, range = 3-8). Conclusion: Gestational trophoblastic disease with early brain metastases presentation showed better response and survival compared with late presentation group.
{"title":"Management of high risk gestational trophoblastic disease with brain metastases - A single institution experience from 1996 to 2010","authors":"K. Kannan, P. Eswaran, S. Ismail","doi":"10.4103/2348-3113.139620","DOIUrl":"https://doi.org/10.4103/2348-3113.139620","url":null,"abstract":"Objective: Gestational trophoblastic disease (GTD) is a peculiar disease in females of reproductive age group because of their natural history, management, high potential for bleeding and excellent response to chemotherapy. Although the incidence of brain metastases is only 10%, propensity for uncontrollable hemorrhage in brain parenchyma makes this situation, a medical emergency. We discuss case series of 7 patients with high risk GTD with brain metastases and their management. Study Design: A retrospective analysis of 15 years from January 1996 to December 2010 was done to study all cases of GTD treated in this institution. Patients who presented with brain metastases on initial diagnosis (early group) and who had metachronous disease (late group) during the course of treatment or follow-up were summarized in this study. Materials and Methods: Of 1208 cases of hydatidiform mole treated in this institution, 325 cases had low risk (WHO score 6 or less), and 38 patients had metastatic disease (score 7 and more). Seven cases were diagnosed to have a high risk GTD with brain metastases, 5 (71.43%) presented initially and 2 (28.57%) developed late brain metastases. Results: In our analysis, patients who had brain metastases on presentation had better survival (median = 52 months, range = 18-61) compared with patients who developed brain disease later in the course (median = 5.5 months, range = 3-8). Conclusion: Gestational trophoblastic disease with early brain metastases presentation showed better response and survival compared with late presentation group.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131139565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139649
Richa D. Patel, Manisha S Khare, N. Majethia, A. Kalgutkar
Infantile hepatic hemangioendothelioma (IHHE) is the most common type of hepatic vascular tumor in infancy, but is rarely reported because of the low incidence estimated to be about 1/20,000. We report an autopsy case of IHHE in a 20-day-old female who came with an initial manifestation of abdominal distension and congestive heart failure (CHF). Symptoms of cardiac decompensation gradually worsened in spite of treatment and child died within 2 days. On autopsy, grossly enlarged liver showed microscopy of large ecstatic vascular channels lined by single layer of plump endothelial cells and diagnosis was given as Type I IHHE. CHF is common complication due to arteriovenous shunts within the tumor and contributes to high morbidity and mortality in up to 70% of untreated infants with median age of presentation of 1-month. Therefore, if symptoms develop, aggressive treatments are warranted.
{"title":"Infantile hepatic hemangioendothelioma presenting as early heart failure: An autopsy case report","authors":"Richa D. Patel, Manisha S Khare, N. Majethia, A. Kalgutkar","doi":"10.4103/2348-3113.139649","DOIUrl":"https://doi.org/10.4103/2348-3113.139649","url":null,"abstract":"Infantile hepatic hemangioendothelioma (IHHE) is the most common type of hepatic vascular tumor in infancy, but is rarely reported because of the low incidence estimated to be about 1/20,000. We report an autopsy case of IHHE in a 20-day-old female who came with an initial manifestation of abdominal distension and congestive heart failure (CHF). Symptoms of cardiac decompensation gradually worsened in spite of treatment and child died within 2 days. On autopsy, grossly enlarged liver showed microscopy of large ecstatic vascular channels lined by single layer of plump endothelial cells and diagnosis was given as Type I IHHE. CHF is common complication due to arteriovenous shunts within the tumor and contributes to high morbidity and mortality in up to 70% of untreated infants with median age of presentation of 1-month. Therefore, if symptoms develop, aggressive treatments are warranted.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115392618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.4103/2348-3113.139623
Sakir Ahmed, Dipjyoti Payeng, A. Das
Background: Cirrhosis of liver is common in north-east India. Hepatitis A infection in adults with chronic liver disease can cause acute on chronic liver failure associated with high mortality and morbidity. There have been reports of an epidemiological shift in hepatitis A virus (HAV) seroprevalence from South-East Asia and India. This study evaluated the etiological profile and seroprevalence of anti-HAV IgG in cirrhosis of liver patients. Patients and Methods: 160 hospitalized adult cases of decompensated cirrhosis of liver and 200 healthy controls were assessed for etiology and their anti-HAV IgG status by commercially available kits. Results : Most common cause of cirrhosis of liver in our region is ethanol related. 95% of cases and 89% of controls were seropositive for anti-HAV IgG (P = 0,181, insignificant difference). All cases above the age of 40 years were seropositive. Seroprevalence between sexes (M 97% and F 83.3%) was statistically insignificant. Only age showed a high coefficient of correlation (r = 0.854, statistically significant, P < 0.001). Conclusion: Alcohol is the most common etiology of cirrhosis of liver in north-east India. Socio-cultural milieu in our part may play a role with alcohol contributing to a major but preventable heath burden. Anti-HAV vaccination in our setting is not indicated routinely to cirrhosis of liver patients as it will not be cost-effective. However, young cirrhotics should be screened for anti-HAV antibody and if negative, may be offered vaccination. Screening should target young chronic liver disease patients in view of reports of decreasing seroprevalence across Asia as compared to one or two decades back.
{"title":"Etiological profile of cirrhosis of liver from North-East India with reference to their anti-hepatitis A virus seroprevalence","authors":"Sakir Ahmed, Dipjyoti Payeng, A. Das","doi":"10.4103/2348-3113.139623","DOIUrl":"https://doi.org/10.4103/2348-3113.139623","url":null,"abstract":"Background: Cirrhosis of liver is common in north-east India. Hepatitis A infection in adults with chronic liver disease can cause acute on chronic liver failure associated with high mortality and morbidity. There have been reports of an epidemiological shift in hepatitis A virus (HAV) seroprevalence from South-East Asia and India. This study evaluated the etiological profile and seroprevalence of anti-HAV IgG in cirrhosis of liver patients. Patients and Methods: 160 hospitalized adult cases of decompensated cirrhosis of liver and 200 healthy controls were assessed for etiology and their anti-HAV IgG status by commercially available kits. Results : Most common cause of cirrhosis of liver in our region is ethanol related. 95% of cases and 89% of controls were seropositive for anti-HAV IgG (P = 0,181, insignificant difference). All cases above the age of 40 years were seropositive. Seroprevalence between sexes (M 97% and F 83.3%) was statistically insignificant. Only age showed a high coefficient of correlation (r = 0.854, statistically significant, P < 0.001). Conclusion: Alcohol is the most common etiology of cirrhosis of liver in north-east India. Socio-cultural milieu in our part may play a role with alcohol contributing to a major but preventable heath burden. Anti-HAV vaccination in our setting is not indicated routinely to cirrhosis of liver patients as it will not be cost-effective. However, young cirrhotics should be screened for anti-HAV antibody and if negative, may be offered vaccination. Screening should target young chronic liver disease patients in view of reports of decreasing seroprevalence across Asia as compared to one or two decades back.","PeriodicalId":166206,"journal":{"name":"Oncology, Gastroenterology and Hepatology Reports","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116549809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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