首页 > 最新文献

Journal of Orthopaedic Research®最新文献

英文 中文
Issue Information - Cover 发行信息 - 封面
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-15 DOI: 10.1002/jor.25621
{"title":"Issue Information - Cover","authors":"","doi":"10.1002/jor.25621","DOIUrl":"https://doi.org/10.1002/jor.25621","url":null,"abstract":"","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"42 11","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy and precision of Volumetric Matching Micromotion Analysis (V3MA) is similar to RSA for tibial component migration in TKA 体积匹配微动分析法(V3MA)在 TKA 胫骨组件移位方面的准确性和精确度与 RSA 相似。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-15 DOI: 10.1002/jor.25989
Nienke N. de Laat, Lennard A. Koster, Berend C. Stoel, Rob G. H. H. Nelissen, Bart L. Kaptein

Radiostereometric analysis (RSA) is the current gold standard to determine implant migration, but it requires bone markers and special equipment. Therefore, we developed VoluMetric Matching Micromotion Analysis (V3MA), a software program for Computed Tomography-based radiostereometric analysis (CT-RSA). This study aimed to determine the accuracy and precision of V3MA in vitro compared to RSA and provide a clinical proof of concept. The accuracy (RMSE (Root Mean Squared Error)) and precision (SD (standard deviation)) of V3MA were compared to RSA. A tibial component was placed in 21 different positions within a cadaveric bone to assess accuracy. For precision, a total of 20 repeated zero-migration examinations from 4 cadaveric bones with cemented tibial components were performed. In 6 total knee arthroplasty (TKA) patients 1 to 5 year migration was measured with V3MA and RSA. V3MA accuracy ranged between 0.02 and 0.09 mm for translations and was 0.01° for internal–external rotations. For RSA, the accuracy ranged between 0.03 and 0.09 mm for translations and was 0.09° for internal-external rotations. V3MA precision ranged between 0.01 and 0.06 mm for translations and 0.02 to 0.07° for rotations. RSA precision ranged between 0.00 and 0.06 mm for translations and 0.04 to 0.25° for rotations. V3MA was successful in 6 clinical cases and no systematic bias was present. In conclusion, the accuracy and precision of V3MA were similar to RSA. Therefore, V3MA is a promising alternative to RSA in migration measurements of tibial components in TKA.

放射立体分析(RSA)是目前确定种植体移位的黄金标准,但它需要骨标记和特殊设备。因此,我们开发了 VoluMetric Matching Micromotion Analysis(V3MA),这是一种基于计算机断层扫描的放射立体分析(CT-RSA)软件。本研究旨在确定 V3MA 在体外与 RSA 相比的准确性和精确度,并提供临床概念验证。将 V3MA 的准确度(RMSE(均方根误差))和精确度(SD(标准偏差))与 RSA 进行比较。为评估准确性,将胫骨组件置于尸体骨骼的 21 个不同位置。在精确度方面,对 4 块带有骨水泥胫骨组件的尸骨进行了总共 20 次重复零移位检查。使用 V3MA 和 RSA 对 6 名全膝关节置换术(TKA)患者 1 至 5 年的移位情况进行了测量。V3MA 测量平移的准确度在 0.02 至 0.09 毫米之间,测量内外旋转的准确度为 0.01°。对于 RSA,平移精度在 0.03 至 0.09 毫米之间,内外旋转精度为 0.09°。V3MA 的平移精度在 0.01 至 0.06 毫米之间,旋转精度在 0.02 至 0.07°之间。RSA 的精度范围为:平移 0.00 至 0.06 mm,旋转 0.04 至 0.25°。V3MA 在 6 个临床病例中取得了成功,没有出现系统性偏差。总之,V3MA 的准确度和精确度与 RSA 相似。因此,在 TKA 中对胫骨组件进行移位测量时,V3MA 有希望替代 RSA。
{"title":"Accuracy and precision of Volumetric Matching Micromotion Analysis (V3MA) is similar to RSA for tibial component migration in TKA","authors":"Nienke N. de Laat,&nbsp;Lennard A. Koster,&nbsp;Berend C. Stoel,&nbsp;Rob G. H. H. Nelissen,&nbsp;Bart L. Kaptein","doi":"10.1002/jor.25989","DOIUrl":"10.1002/jor.25989","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Radiostereometric analysis (RSA) is the current gold standard to determine implant migration, but it requires bone markers and special equipment. Therefore, we developed VoluMetric Matching Micromotion Analysis (V3MA), a software program for Computed Tomography-based radiostereometric analysis (CT-RSA). This study aimed to determine the accuracy and precision of V3MA in vitro compared to RSA and provide a clinical proof of concept. The accuracy (RMSE (Root Mean Squared Error)) and precision (SD (standard deviation)) of V3MA were compared to RSA. A tibial component was placed in 21 different positions within a cadaveric bone to assess accuracy. For precision, a total of 20 repeated zero-migration examinations from 4 cadaveric bones with cemented tibial components were performed. In 6 total knee arthroplasty (TKA) patients 1 to 5 year migration was measured with V3MA and RSA. V3MA accuracy ranged between 0.02 and 0.09 mm for translations and was 0.01° for internal–external rotations. For RSA, the accuracy ranged between 0.03 and 0.09 mm for translations and was 0.09° for internal-external rotations. V3MA precision ranged between 0.01 and 0.06 mm for translations and 0.02 to 0.07° for rotations. RSA precision ranged between 0.00 and 0.06 mm for translations and 0.04 to 0.25° for rotations. V3MA was successful in 6 clinical cases and no systematic bias was present. In conclusion, the accuracy and precision of V3MA were similar to RSA. Therefore, V3MA is a promising alternative to RSA in migration measurements of tibial components in TKA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"311-321"},"PeriodicalIF":2.1,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25989","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a novel rabbit model for femoroacetabular impingement through surgically induced acetabular overcoverage 通过手术诱导髋臼过度覆盖,建立新型股骨髋臼撞击兔模型。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-13 DOI: 10.1002/jor.25994
Siqi Zhang, Guanying Gao, Xiang Zhou, Cancan Du, Yichuan Zhu, Tong-Chuan He, Yan Xu

There is a lack of validated small animal models for femoroacetabular impingement (FAI) that induce intra-articular lesions and cause osteoarthritis (OA) progression. The gene expression profile of articular cartilage in patients with FAI has not been characterized in animal studies. The purpose of this study is to describe a novel rabbit model for FAI with validated induction of intra-articular lesions and OA progression and to characterize the gene expression pattern in impinged cartilage using this model. Thirty 6-month-old New Zealand White rabbits underwent unilateral endobutton implant placement at the acetabular rim to surgically create overcoverage. Radiological assessment confirmed secure placement of endobutton at the acetabular rim for all operated hips with a mean alteration in lateral center-edge angle (ΔLCEA) of 16.2 ± 6.6°. Gross inspection revealed secondary cartilage injuries in the anterosuperior region of the femoral head for the operated hips. Cartilage injuries were shown to exacerbate with increased impingement duration, as demonstrated by the modified Outerbridge scores and Mankin scores. Immunostaining and quantitative real-time polymerase chain reaction revealed elevated expression of inflammatory, anabolic and catabolic genes in impinged cartilage. RNA sequencing analysis of cartilage tissue revealed a distinct transcriptome profile and identified C-KIT, CD86, and CD68 as central markers. Our study confirmed that the novel rabbit FAI model created acetabular overcoverage and produced articular cartilage injury at the impingement zone. Cartilage from the impingement zone demonstrated a heightened metabolic state, corroborating with the gene expression pattern observed in patients with FAI.

股骨髋臼撞击症(FAI)可诱发关节内病变并导致骨关节炎(OA)恶化,但目前缺乏有效的小动物模型。FAI 患者关节软骨的基因表达谱尚未在动物实验中得到描述。本研究的目的是描述一种新型兔FAI模型,该模型可有效诱导关节内病变和OA进展,并利用该模型描述撞击软骨的基因表达模式。30 只 6 个月大的新西兰白兔接受了单侧髋臼边缘内扣植入手术,通过手术形成过度覆盖。放射学评估证实,所有接受手术的兔子都在髋臼边缘安全放置了内扣,外侧中心-边缘角(ΔLCEA)的平均变化为 16.2 ± 6.6°。大体检查显示,手术髋关节的股骨头前上方区域存在继发性软骨损伤。改良Outerbridge评分和Mankin评分显示,软骨损伤会随着撞击持续时间的延长而加重。免疫染色和定量实时聚合酶链反应显示,撞击软骨中炎症、合成代谢和分解代谢基因的表达量升高。软骨组织的 RNA 测序分析显示了独特的转录组特征,并确定 C-KIT、CD86 和 CD68 为中心标记物。我们的研究证实,新型兔FAI模型会造成髋臼过度覆盖,并在撞击区产生关节软骨损伤。来自撞击区的软骨表现出一种高度代谢状态,这与在 FAI 患者身上观察到的基因表达模式相吻合。
{"title":"Development of a novel rabbit model for femoroacetabular impingement through surgically induced acetabular overcoverage","authors":"Siqi Zhang,&nbsp;Guanying Gao,&nbsp;Xiang Zhou,&nbsp;Cancan Du,&nbsp;Yichuan Zhu,&nbsp;Tong-Chuan He,&nbsp;Yan Xu","doi":"10.1002/jor.25994","DOIUrl":"10.1002/jor.25994","url":null,"abstract":"<p>There is a lack of validated small animal models for femoroacetabular impingement (FAI) that induce intra-articular lesions and cause osteoarthritis (OA) progression. The gene expression profile of articular cartilage in patients with FAI has not been characterized in animal studies. The purpose of this study is to describe a novel rabbit model for FAI with validated induction of intra-articular lesions and OA progression and to characterize the gene expression pattern in impinged cartilage using this model. Thirty 6-month-old New Zealand White rabbits underwent unilateral endobutton implant placement at the acetabular rim to surgically create overcoverage. Radiological assessment confirmed secure placement of endobutton at the acetabular rim for all operated hips with a mean alteration in lateral center-edge angle (ΔLCEA) of 16.2 ± 6.6°. Gross inspection revealed secondary cartilage injuries in the anterosuperior region of the femoral head for the operated hips. Cartilage injuries were shown to exacerbate with increased impingement duration, as demonstrated by the modified Outerbridge scores and Mankin scores. Immunostaining and quantitative real-time polymerase chain reaction revealed elevated expression of inflammatory, anabolic and catabolic genes in impinged cartilage. RNA sequencing analysis of cartilage tissue revealed a distinct transcriptome profile and identified C-KIT, CD86, and CD68 as central markers. Our study confirmed that the novel rabbit FAI model created acetabular overcoverage and produced articular cartilage injury at the impingement zone. Cartilage from the impingement zone demonstrated a heightened metabolic state, corroborating with the gene expression pattern observed in patients with FAI.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"407-418"},"PeriodicalIF":2.1,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human mesenchymal stem/stromal cell-derived extracellular vesicle transport in meniscus fibrocartilage 人体间充质干细胞/基质细胞衍生的细胞外囊泡在半月板纤维软骨中的运输。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-13 DOI: 10.1002/jor.25993
Gabi Schwartz, Samir Rana, Alicia R. Jackson, Clarissa Leñero, Thomas M. Best, Dimitrios Kouroupis, Francesco Travascio

Extracellular vesicles (EVs) derived from endometrial-derived mesenchymal stem/stromal cells (eMSC) play a crucial role in tissue repair due to their immunomodulatory and reparative properties. Given these properties, eMSC EVs may offer potential benefits for meniscal repair. The meniscus, being partly vascularized, relies on diffusivity for solute trafficking. This study focuses on EVs transport properties characterization within fibrocartilage that remains unknown. Specifically, EVs were isolated from Crude and CD146+ eMSC populations. Green fluorescence-labeled EVs transport properties were investigated in three structurally distinct layers (core, femoral, and tibial surfaces) of porcine meniscus. Diffusivity was measured via custom fluorescence recovery after photobleaching (FRAP) technique. Light spectrometry was used to determine EVs solubility. Both Crude and CD146+ eMSC EVs exhibited high purity (>90% CD63CD9 marker expression) and an average diffusivity of 10.924 (±4.065) µm²/s. Importantly, no significant difference was observed between Crude and CD146+ eMSC EV diffusivity on the meniscal layer (p > 0.05). The mean partitioning coefficient was 0.2118 (±0.1321), with Crude EVs demonstrating significantly higher solubility than CD146+ EVs (p < 0.05). In conclusion, this study underscores the potential of both Crude and CD146+ eMSC EVs to traverse all layers of the meniscus, supporting their capacity to enhance delivery of orthobiologics for cartilaginous tissue healing.

源自子宫内膜间充质干细胞/基质细胞(eMSC)的胞外囊泡(EVs)具有免疫调节和修复特性,在组织修复中发挥着至关重要的作用。鉴于这些特性,eMSC EVs 可为半月板修复带来潜在益处。半月板部分血管化,依赖于溶质运输的扩散性。本研究的重点是EVs在纤维软骨内的运输特性。具体来说,EVs是从粗体和 CD146+ eMSC 群体中分离出来的。绿色荧光标记的 EVs 运输特性在猪半月板的三个不同结构层(核心、股骨和胫骨表面)中进行了研究。扩散率是通过定制的光漂白后荧光恢复(FRAP)技术测量的。光光谱法用于确定 EVs 的溶解度。粗EVs和CD146+ eMSC EVs均表现出高纯度(CD63CD9标记表达>90%),平均扩散率为10.924 (±4.065) µm²/s。重要的是,粗体和 CD146+ eMSC EV 在半月板层上的扩散率没有明显差异(p > 0.05)。平均分配系数为 0.2118 (±0.1321),粗EVs的溶解度明显高于CD146+ EVs(p + eMSC EVs穿越半月板各层的能力,支持其增强软骨组织愈合中矫形生物制剂的输送能力)。
{"title":"Human mesenchymal stem/stromal cell-derived extracellular vesicle transport in meniscus fibrocartilage","authors":"Gabi Schwartz,&nbsp;Samir Rana,&nbsp;Alicia R. Jackson,&nbsp;Clarissa Leñero,&nbsp;Thomas M. Best,&nbsp;Dimitrios Kouroupis,&nbsp;Francesco Travascio","doi":"10.1002/jor.25993","DOIUrl":"10.1002/jor.25993","url":null,"abstract":"<p>Extracellular vesicles (EVs) derived from endometrial-derived mesenchymal stem/stromal cells (eMSC) play a crucial role in tissue repair due to their immunomodulatory and reparative properties. Given these properties, eMSC EVs may offer potential benefits for meniscal repair. The meniscus, being partly vascularized, relies on diffusivity for solute trafficking. This study focuses on EVs transport properties characterization within fibrocartilage that remains unknown. Specifically, EVs were isolated from Crude and CD146<sup>+</sup> eMSC populations. Green fluorescence-labeled EVs transport properties were investigated in three structurally distinct layers (core, femoral, and tibial surfaces) of porcine meniscus. Diffusivity was measured via custom fluorescence recovery after photobleaching (FRAP) technique. Light spectrometry was used to determine EVs solubility. Both Crude and CD146<sup>+</sup> eMSC EVs exhibited high purity (&gt;90% CD63CD9 marker expression) and an average diffusivity of 10.924 (±4.065) µm²/s. Importantly, no significant difference was observed between Crude and CD146<sup>+</sup> eMSC EV diffusivity on the meniscal layer (<i>p</i> &gt; 0.05). The mean partitioning coefficient was 0.2118 (±0.1321), with Crude EVs demonstrating significantly higher solubility than CD146<sup>+</sup> EVs (<i>p</i> &lt; 0.05). In conclusion, this study underscores the potential of both Crude and CD146<sup>+</sup> eMSC EVs to traverse all layers of the meniscus, supporting their capacity to enhance delivery of orthobiologics for cartilaginous tissue healing.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"457-465"},"PeriodicalIF":2.1,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining the segmental tension generated in a vertebral body tethering system for scoliosis 确定脊柱侧弯椎体系绳系统产生的节段张力。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-10 DOI: 10.1002/jor.25995
Vidyadhar V. Upasani, Christine L. Farnsworth, Jason P. Caffrey, Tony Olmert, Ian Brink, Phoebe Cain, Erin Mannen

Vertebral body tethering (VBT) uses a flexible tether affixed across the curve convexity with tension applied at each segment to treat scoliosis. Intraoperative tether tension may be achieved directly with a counter-tensioner or with an extension spring tube. The purpose of this study was to quantify the force generated with and without the extension spring tube using current FDA-approved VBT instrumentation, to understand the variation between surgeons using the same instrumentation, and to define the force range that is generated intra-operatively. Using a benchtop mechanical testing setup to simulate a spinal segment, we affixed the tether and applied tension using a tensioner and counter-tensioner alone (method T1) or by adding an extension spring tube (method T2). Eight orthopedic surgeons used T1 and T2 at six tensioner settings, and one surgeon completed three trials. A two-way ANOVA with a Tukey's HSD post hoc test (p < 0.05) compared the tensioner methods and testing levels. Inter- and intra-rater reliabilities were calculated using intraclass correlation coefficients (ICCs). Methods T1 and T2 exhibited linear tension-setting relationships, with high determination coefficients (R2 > 0.93). T2 consistently produced higher forces (increase of 62.1 N/setting), compared to T1 (increase of 50.6 N/setting, p < 0.05). Inter-rater reliability exhibited excellent agreement (ICC = 0.951 and 0.943 for T1 and T2, respectively), as did intra-rater reliability (ICC = 0.971).

椎体系带术(VBT)是利用横跨曲线凸面的柔性系带,在每个节段施加张力来治疗脊柱侧弯。术中系带张力可通过反张力器或延伸弹簧管直接实现。本研究的目的是量化使用目前经 FDA 批准的 VBT 器械在使用和不使用拉伸弹簧管时产生的力,了解使用相同器械的外科医生之间的差异,并确定术中产生的力的范围。我们使用台式机械测试装置模拟脊柱节段,粘贴系绳,并单独使用拉伸器和反拉伸器(方法 T1)或添加拉伸弹簧管(方法 T2)施加拉力。八名骨科医生在六种拉伸器设置下使用了 T1 和 T2 方法,其中一名外科医生完成了三次试验。进行了双向方差分析和 Tukey's HSD 事后检验(p 2 > 0.93)。与 T1(每组增加 50.6 牛顿,p 2 > 0.93)相比,T2 产生的力始终较高(每组增加 62.1 牛顿)。
{"title":"Defining the segmental tension generated in a vertebral body tethering system for scoliosis","authors":"Vidyadhar V. Upasani,&nbsp;Christine L. Farnsworth,&nbsp;Jason P. Caffrey,&nbsp;Tony Olmert,&nbsp;Ian Brink,&nbsp;Phoebe Cain,&nbsp;Erin Mannen","doi":"10.1002/jor.25995","DOIUrl":"10.1002/jor.25995","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 <p>Vertebral body tethering (VBT) uses a flexible tether affixed across the curve convexity with tension applied at each segment to treat scoliosis. Intraoperative tether tension may be achieved directly with a counter-tensioner or with an extension spring tube. The purpose of this study was to quantify the force generated with and without the extension spring tube using current FDA-approved VBT instrumentation, to understand the variation between surgeons using the same instrumentation, and to define the force range that is generated intra-operatively. Using a benchtop mechanical testing setup to simulate a spinal segment, we affixed the tether and applied tension using a tensioner and counter-tensioner alone (method T1) or by adding an extension spring tube (method T2). Eight orthopedic surgeons used T1 and T2 at six tensioner settings, and one surgeon completed three trials. A two-way ANOVA with a Tukey's HSD post hoc test (<i>p</i> &lt; 0.05) compared the tensioner methods and testing levels. Inter- and intra-rater reliabilities were calculated using intraclass correlation coefficients (ICCs). Methods T1 and T2 exhibited linear tension-setting relationships, with high determination coefficients (<i>R</i><sup>2</sup> &gt; 0.93). T2 consistently produced higher forces (increase of 62.1 N/setting), compared to T1 (increase of 50.6 N/setting, <i>p</i> &lt; 0.05). Inter-rater reliability exhibited excellent agreement (ICC = 0.951 and 0.943 for T1 and T2, respectively), as did intra-rater reliability (ICC = 0.971).</p>\u0000 </section>\u0000 </div>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"441-445"},"PeriodicalIF":2.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteoarthritis early-, mid- and late-stage progression in the rat medial meniscus transection model 大鼠内侧半月板横断模型的骨关节炎早期、中期和晚期进展。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-10 DOI: 10.1002/jor.25969
Jay M. McKinney, Krishna A. Pucha, Fabrice C. Bernard, J. Brandon Dixon, Thanh N. Doan, Nick J. Willett

Osteoarthritis is a degenerative disease of synovial joints affecting all tissues, including articular cartilage and subchondral bone. Osteoarthritis animal models can recapitulate aspects of human disease progression and are used to test efficacy of drugs, biomaterials, and cell therapies. The rat medial meniscus transection (MMT) model is a surgically induced posttraumatic osteoarthritis model commonly used for preclinical therapeutic screening. We describe herein, the qualitative and quantitative changes to articular cartilage, subchondral bone, and formation of osteophytes at early-, mid-, and late-stages of osteoarthritis progression. Tibia of MMT-operated animals showed proteoglycan loss and fibrillation along articular cartilage surfaces as early as 3-weeks post-surgery. With contrast-enhanced micro-CT technique, quantitative, 3-dimensional analysis of the tibia showed that the articular cartilage thickened at 3- and 6-weeks post-surgery and decreased at 12-weeks post-surgery. This decreased cartilage thickness corresponded with increased lesions in the articular cartilage that led to its full degradation and exposing the subchondral bone layer. Further, subchondral bone thickening was significant at 6-weeks post-surgery and followed cartilage damage. Osteophytes were found as early as 3-weeks post-surgery and coincided with articular cartilage degradation. Cartilaginous osteophytes preceded mineralization, suggesting endochondral ossification. The rat MMT model has predominantly been used out to 3-weeks, and most studies determined the effect of therapies to delay or prevent the onset of osteoarthritis. We provide evidence that an extension of the rat MMT model out to 6- and 12-weeks more resembled severe phenotypes of human osteoarthritis. Thus, evaluating novel therapeutics at late-stage will be important for eventual clinical translation.

骨关节炎是滑膜关节的一种退行性疾病,会影响包括关节软骨和软骨下骨在内的所有组织。骨关节炎动物模型可以再现人类疾病进展的各个方面,并用于测试药物、生物材料和细胞疗法的疗效。大鼠内侧半月板横断(MMT)模型是一种手术诱导的创伤后骨关节炎模型,常用于临床前治疗筛选。我们在本文中描述了骨关节炎进展早期、中期和晚期阶段关节软骨、软骨下骨以及骨赘形成的定性和定量变化。MMT手术动物的胫骨早在术后3周就出现了蛋白多糖脱落和关节软骨表面纤维化。通过对比增强显微 CT 技术对胫骨进行的三维定量分析显示,关节软骨在术后 3 周和 6 周时增厚,在术后 12 周时减薄。软骨厚度的减少与关节软骨病变的增加相对应,病变导致关节软骨完全退化,并暴露出软骨下骨层。此外,软骨下骨增厚在术后 6 周就很明显,而且是在软骨损伤之后。骨质增生早在术后 3 周就已出现,与关节软骨退化同时发生。软骨骨质增生先于矿化,表明软骨内骨化。大鼠 MMT 模型主要用于 3 周内,大多数研究确定了延迟或预防骨关节炎发生的疗法的效果。我们提供的证据表明,将大鼠 MMT 模型延长至 6 周和 12 周更类似于人类骨关节炎的严重表型。因此,在晚期评估新型疗法对于最终的临床转化非常重要。
{"title":"Osteoarthritis early-, mid- and late-stage progression in the rat medial meniscus transection model","authors":"Jay M. McKinney,&nbsp;Krishna A. Pucha,&nbsp;Fabrice C. Bernard,&nbsp;J. Brandon Dixon,&nbsp;Thanh N. Doan,&nbsp;Nick J. Willett","doi":"10.1002/jor.25969","DOIUrl":"10.1002/jor.25969","url":null,"abstract":"<p>Osteoarthritis is a degenerative disease of synovial joints affecting all tissues, including articular cartilage and subchondral bone. Osteoarthritis animal models can recapitulate aspects of human disease progression and are used to test efficacy of drugs, biomaterials, and cell therapies. The rat medial meniscus transection (MMT) model is a surgically induced posttraumatic osteoarthritis model commonly used for preclinical therapeutic screening. We describe herein, the qualitative and quantitative changes to articular cartilage, subchondral bone, and formation of osteophytes at early-, mid-, and late-stages of osteoarthritis progression. Tibia of MMT-operated animals showed proteoglycan loss and fibrillation along articular cartilage surfaces as early as 3-weeks post-surgery. With contrast-enhanced micro-CT technique, quantitative, 3-dimensional analysis of the tibia showed that the articular cartilage thickened at 3- and 6-weeks post-surgery and decreased at 12-weeks post-surgery. This decreased cartilage thickness corresponded with increased lesions in the articular cartilage that led to its full degradation and exposing the subchondral bone layer. Further, subchondral bone thickening was significant at 6-weeks post-surgery and followed cartilage damage. Osteophytes were found as early as 3-weeks post-surgery and coincided with articular cartilage degradation. Cartilaginous osteophytes preceded mineralization, suggesting endochondral ossification. The rat MMT model has predominantly been used out to 3-weeks, and most studies determined the effect of therapies to delay or prevent the onset of osteoarthritis. We provide evidence that an extension of the rat MMT model out to 6- and 12-weeks more resembled severe phenotypes of human osteoarthritis. Thus, evaluating novel therapeutics at late-stage will be important for eventual clinical translation.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 1","pages":"102-116"},"PeriodicalIF":2.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gait stability improves following unilateral total ankle arthroplasty 单侧全踝关节置换术后步态稳定性得到改善。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-10 DOI: 10.1002/jor.25992
Martin Barylak, Sara L. Arena, Stephanie H. Carpentier, Robin M. Queen

End-stage ankle arthritis is often treated surgically by total ankle arthroplasty (TAA) due to its potential to improve gait through increased joint range of motion and reduce pain. However, TAA's effect on gait stability is not well understood. This study explores the impact of TAA on gait stability, measured by Margin of Stability (MoS), in 148 patients with end-stage ankle arthritis. Kinematic data were collected pre-operatively, at 1-year post-op, and at 2-years post-op and the MoS was determined at heel strike and midstance for the anteroposterior (MoSAP) and mediolateral (MoSML) directions. A linear mixed effects model including gait speed as a factor was used to assess the effects of limb, session, and their interaction on outcome measures. A significant interaction (p < 0.002) between limb (surgical, nonsurgical) and session (pre-op, 1-year post-op, 2-years post-op) was identified for each MoS variable of interest. Cumulatively, our results suggest that the nonsurgical limb, MoSAP at heel strike and MoSML at midstance improved (increased) as time from surgery increased. These results suggest patients developed a compensatory movement pattern to navigate surgical limb single support. TAA reduces this compensation improving side-to-side symmetry, while not fully restoring symmetry by 2-years post-op. These results indicate that TAA could improve gait stability in patients with end-stage ankle arthritis, but further work is needed to understand the impact of TAA on altering fall risk.

晚期踝关节炎通常采用全踝关节置换术(TAA)进行手术治疗,因为这种手术可以通过增加关节活动范围来改善步态,并减轻疼痛。然而,TAA 对步态稳定性的影响尚不十分清楚。本研究探讨了踝关节置换术对步态稳定性的影响,通过对 148 名终末期踝关节炎患者的稳定性边际(MoS)进行测量。研究人员收集了术前、术后 1 年和术后 2 年的运动学数据,并测定了脚跟着地和中站时的前胸(MoSAP)和内外侧(MoSML)方向的 MoS。采用线性混合效应模型,将步速作为一个因子,评估肢体、疗程及其交互作用对结果测量的影响。随着手术时间的延长,脚跟着地时的交互作用(p AP)和中站时的MoSML均有明显改善(增加)。这些结果表明,患者形成了一种代偿运动模式,以适应手术肢体的单一支撑。TAA 可减少这种代偿,改善两侧对称性,但术后 2 年仍不能完全恢复对称性。这些结果表明,TAA可以改善终末期踝关节炎患者的步态稳定性,但要了解TAA对改变跌倒风险的影响还需要进一步的工作。
{"title":"Gait stability improves following unilateral total ankle arthroplasty","authors":"Martin Barylak,&nbsp;Sara L. Arena,&nbsp;Stephanie H. Carpentier,&nbsp;Robin M. Queen","doi":"10.1002/jor.25992","DOIUrl":"10.1002/jor.25992","url":null,"abstract":"<p>End-stage ankle arthritis is often treated surgically by total ankle arthroplasty (TAA) due to its potential to improve gait through increased joint range of motion and reduce pain. However, TAA's effect on gait stability is not well understood. This study explores the impact of TAA on gait stability, measured by Margin of Stability (MoS), in 148 patients with end-stage ankle arthritis. Kinematic data were collected pre-operatively, at 1-year post-op, and at 2-years post-op and the MoS was determined at heel strike and midstance for the anteroposterior (MoS<sub>AP</sub>) and mediolateral (MoS<sub>ML</sub>) directions. A linear mixed effects model including gait speed as a factor was used to assess the effects of limb, session, and their interaction on outcome measures. A significant interaction (<i>p</i> &lt; 0.002) between limb (surgical, nonsurgical) and session (pre-op, 1-year post-op, 2-years post-op) was identified for each MoS variable of interest. Cumulatively, our results suggest that the nonsurgical limb, MoS<sub>AP</sub> at heel strike and MoS<sub>ML</sub> at midstance improved (increased) as time from surgery increased. These results suggest patients developed a compensatory movement pattern to navigate surgical limb single support. TAA reduces this compensation improving side-to-side symmetry, while not fully restoring symmetry by 2-years post-op. These results indicate that TAA could improve gait stability in patients with end-stage ankle arthritis, but further work is needed to understand the impact of TAA on altering fall risk.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"388-395"},"PeriodicalIF":2.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25992","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an ex vivo model to study Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network 开发体外模型,研究金黄色葡萄球菌入侵骨细胞裂隙-髓鞘网络的情况。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-09 DOI: 10.1002/jor.25988
Niels Vanvelk, Karen L. de Mesy Bentley, Michael H. J. Verhofstad, Willem-Jan Metsemakers, Thomas F. Moriarty, Claudia Siverino

Staphylococcus aureus has multiple mechanisms to evade the host's immune system and antibiotic treatment. One such mechanism is the invasion of the osteocyte lacuno-canalicular network (OLCN), which may be particularly important in recurrence of infection after debridement and antibiotic therapy. The aim of this study was to develop an ex vivo model to facilitate further study of S. aureus invasion of the OLCN and early-stage testing of antibacterial strategies against bacteria in this niche. The diameter of the canaliculi of non-infected human, sheep, and mouse bones was measured microscopically on Schmorl's picrothionin stained sections, showing a large overlap in canalicular diameter. S. aureus successfully invaded the OLCN in all species in vitro as revealed by presence in osteocyte lacunae in Brown and Brenn-stained sections and by scanning electron microscopy. Murine bones were then selected for further experiments, and titanium pins with either a wild-type or ΔPBP4 mutant S. aureus USA300 were placed trans-cortically and incubated for 2 weeks in tryptic soy broth. Wild-type S. aureus readily invaded the osteocyte lacunae in mouse bones while the ΔPBP4 showed a significantly lower invasion of the OLCN (p = 0.0005). Bone specimens were then treated with gentamicin, sitafloxacin, R14 bacteriophages, or left untreated. Gentamicin (p = 0.0027) and sitafloxacin (p = 0.0280) significantly reduced the proportion of S. aureus-occupied lacunae, whilst bacteriophage treatment had no effect. This study shows that S. aureus is able to invade the OLCN in an ex vivo model. This ex vivo model can be used for future early-stage studies before proceeding to in vivo studies.

金黄色葡萄球菌有多种逃避宿主免疫系统和抗生素治疗的机制。其中一种机制是侵入骨细胞裂隙-颅骨网(OLCN),这可能是清创和抗生素治疗后感染复发的重要原因。本研究的目的是建立一个体外模型,以便于进一步研究金黄色葡萄球菌入侵 OLCN 的情况,并对针对这一龛位细菌的抗菌策略进行早期测试。通过显微镜测量未感染的人类、绵羊和小鼠骨骼的管腔直径,结果显示管腔直径有很大的重叠。布朗和布伦染色切片中的骨细胞裂隙以及扫描电子显微镜显示,金黄色葡萄球菌在体外成功侵入了所有物种的OLCN。然后选择小鼠骨骼进行进一步实验,将带有野生型或ΔPBP4突变型金黄色葡萄球菌USA300的钛针经皮质放置在胰蛋白酶大豆肉汤中培养2周。野生型金黄色葡萄球菌很容易侵入小鼠骨骼中的骨细胞裂隙,而ΔPBP4对OLCN的侵入明显较低(p = 0.0005)。然后用庆大霉素、西他沙星、R14噬菌体处理或不处理骨标本。庆大霉素(p = 0.0027)和西他沙星(p = 0.0280)显著降低了金黄色葡萄球菌占据裂隙的比例,而噬菌体处理则没有影响。这项研究表明,金黄色葡萄球菌能够在体外模型中侵入 OLCN。这种体外模型可用于未来的早期研究,然后再进行体内研究。
{"title":"Development of an ex vivo model to study Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network","authors":"Niels Vanvelk,&nbsp;Karen L. de Mesy Bentley,&nbsp;Michael H. J. Verhofstad,&nbsp;Willem-Jan Metsemakers,&nbsp;Thomas F. Moriarty,&nbsp;Claudia Siverino","doi":"10.1002/jor.25988","DOIUrl":"10.1002/jor.25988","url":null,"abstract":"<p><i>Staphylococcus aureus</i> has multiple mechanisms to evade the host's immune system and antibiotic treatment. One such mechanism is the invasion of the osteocyte lacuno-canalicular network (OLCN), which may be particularly important in recurrence of infection after debridement and antibiotic therapy. The aim of this study was to develop an ex vivo model to facilitate further study of <i>S. aureus</i> invasion of the OLCN and early-stage testing of antibacterial strategies against bacteria in this niche. The diameter of the canaliculi of non-infected human, sheep, and mouse bones was measured microscopically on Schmorl's picrothionin stained sections, showing a large overlap in canalicular diameter. <i>S. aureus</i> successfully invaded the OLCN in all species in vitro as revealed by presence in osteocyte lacunae in Brown and Brenn-stained sections and by scanning electron microscopy. Murine bones were then selected for further experiments, and titanium pins with either a wild-type or ΔPBP4 mutant <i>S. aureus</i> USA300 were placed trans-cortically and incubated for 2 weeks in tryptic soy broth. Wild-type <i>S. aureus</i> readily invaded the osteocyte lacunae in mouse bones while the ΔPBP4 showed a significantly lower invasion of the OLCN (<i>p</i> = 0.0005). Bone specimens were then treated with gentamicin, sitafloxacin, R14 bacteriophages, or left untreated. Gentamicin (<i>p</i> = 0.0027) and sitafloxacin (<i>p</i> = 0.0280) significantly reduced the proportion of <i>S. aureus</i>-occupied lacunae, whilst bacteriophage treatment had no effect. This study shows that <i>S. aureus</i> is able to invade the OLCN in an ex vivo model. This ex vivo model can be used for future early-stage studies before proceeding to in vivo studies.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"446-456"},"PeriodicalIF":2.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9-month equine groove model study” 更正 "钝性和锐性软骨损伤对关节结构、组成和功能的影响:为期 9 个月的马槽模型研究"。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-08 DOI: 10.1002/jor.25991

te Moller NCR, Mohammadi A, Plomp S, et al. Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9-month equine groove model study. J Orthop Res.2021;39:2363–2375.

In the supporting information document jor24971-sup-0007-Supplementary_Material-EquineGrooveModel_12-2020.pdf, on page 22, the Supplementary data set is mentioned: “Data generated by this research and used for analysis in the current paper, will be made available from data repository.” The link to this data set was missing. The data can be accessed via the link below:

https://public.yoda.uu.nl/dgk/UU01/0TO6PE.html

And has the following persistent identifier:

doi:10.24416/UU01-0TO6PE

We apologize for the delay.

莫勒,莫哈默迪A,普洛普S,等。钝性和尖锐软骨损伤对关节的结构、组成和功能影响:一项为期9个月的马沟模型研究[J]中华口腔外科杂志,2011;39(3):563 - 563。在支持信息文档jor24971-sup-0007- addientary_material - equinegroovemodel_12 -2020.pdf中,第22页提到了补充数据集:“本研究生成的数据以及本论文中用于分析的数据将从数据存储库中提供。”这个数据集的链接丢失了。这些数据可以通过以下链接访问:https://public.yoda.uu.nl/dgk/UU01/0TO6PE。html有以下持久标识符:doi:10.24416/ uu01 - 0to6pe我们为延迟道歉。
{"title":"Correction to “Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9-month equine groove model study”","authors":"","doi":"10.1002/jor.25991","DOIUrl":"10.1002/jor.25991","url":null,"abstract":"<p>te Moller NCR, Mohammadi A, Plomp S, et al. Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: A 9-month equine groove model study. J Orthop Res.2021;39:2363–2375.</p><p>In the supporting information document <i>jor24971-sup-0007-Supplementary_Material-EquineGrooveModel_12-2020.pdf</i>, on page 22, the Supplementary data set is mentioned: “Data generated by this research and used for analysis in the current paper, will be made available from data repository.” The link to this data set was missing. The data can be accessed via the link below:</p><p>https://public.yoda.uu.nl/dgk/UU01/0TO6PE.html</p><p>And has the following persistent identifier:</p><p>doi:10.24416/UU01-0TO6PE</p><p>We apologize for the delay.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 1","pages":"238"},"PeriodicalIF":2.1,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jor.25991","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing postural stability in flatfoot using a time-in-boundary method during single-leg standing 在单腿站立过程中使用边界时间法评估扁平足的姿势稳定性。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2024-10-04 DOI: 10.1002/jor.25987
Paul S. Sung, Dongchul Lee

Flatfoot, a foot deformity characterized by the collapse of the arch, significantly impacts an individual's balance and stability. This study explored postural adjustments and sway excursions in individuals with and without flatfoot using the Time-in-Boundary method. This method assessed relative stability by exploring various center of pressure radius thresholds during three trials of single-leg stance. We observed significant interactions in threshold levels (F = 4.37, p = 0.04) and normalized relative stable times (F = 7.64, p = 0.01), particularly in the initial trials. Initially, the flatfoot group showed marked decreases in stable times at 10 mm, 15 mm, and 20 mm thresholds, which expanded to 25 mm and 30 mm in subsequent trials. Despite a significant decrease in stability at the 30 mm threshold in early trials, participants exhibited improved stability control as trials progressed. This enhancement likely reflects a combination of a learning effect and an increased understanding of the task requirements, underscoring the adaptability of postural control systems to the biomechanical challenges posed by flatfoot. The Time-in-Boundary method has proven to be an effective tool for clinicians to assess postural control, playing a vital role in developing customized rehabilitation strategies for individuals with flatfoot.

扁平足是一种以足弓塌陷为特征的足部畸形,严重影响个人的平衡和稳定性。本研究使用 "边界时间法 "探讨了患有和不患有扁平足的人的姿势调整和摇摆偏移。这种方法通过在三次单腿站立试验中探索不同的压力中心半径阈值来评估相对稳定性。我们观察到阈值水平(F = 4.37,p = 0.04)和归一化相对稳定时间(F = 7.64,p = 0.01)之间存在明显的交互作用,尤其是在最初的试验中。最初,平足组在 10 毫米、15 毫米和 20 毫米阈值处的稳定时间明显减少,在随后的试验中扩大到 25 毫米和 30 毫米。尽管在早期试验中,30 毫米阈值处的稳定性明显下降,但随着试验的进行,参与者的稳定性控制能力有所提高。这种提高可能反映了学习效应和对任务要求理解的加深,突出了姿势控制系统对扁平足带来的生物力学挑战的适应性。事实证明,边界时间法是临床医生评估姿势控制的有效工具,在为扁平足患者制定个性化康复策略方面发挥着重要作用。
{"title":"Assessing postural stability in flatfoot using a time-in-boundary method during single-leg standing","authors":"Paul S. Sung,&nbsp;Dongchul Lee","doi":"10.1002/jor.25987","DOIUrl":"10.1002/jor.25987","url":null,"abstract":"<p>Flatfoot, a foot deformity characterized by the collapse of the arch, significantly impacts an individual's balance and stability. This study explored postural adjustments and sway excursions in individuals with and without flatfoot using the Time-in-Boundary method. This method assessed relative stability by exploring various center of pressure radius thresholds during three trials of single-leg stance. We observed significant interactions in threshold levels (<i>F</i> = 4.37, <i>p</i> = 0.04) and normalized relative stable times (<i>F</i> = 7.64, <i>p</i> = 0.01), particularly in the initial trials. Initially, the flatfoot group showed marked decreases in stable times at 10 mm, 15 mm, and 20 mm thresholds, which expanded to 25 mm and 30 mm in subsequent trials. Despite a significant decrease in stability at the 30 mm threshold in early trials, participants exhibited improved stability control as trials progressed. This enhancement likely reflects a combination of a learning effect and an increased understanding of the task requirements, underscoring the adaptability of postural control systems to the biomechanical challenges posed by flatfoot. The Time-in-Boundary method has proven to be an effective tool for clinicians to assess postural control, playing a vital role in developing customized rehabilitation strategies for individuals with flatfoot.</p>","PeriodicalId":16650,"journal":{"name":"Journal of Orthopaedic Research®","volume":"43 2","pages":"379-387"},"PeriodicalIF":2.1,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Orthopaedic Research®
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1