Maja Kopczynska MBBCh, Thaksala Uduvawidana MD, Simon Harrison MPharm, Sorrel Burden PhD, Gordon L. Carlson PhD, Simon Lal PhD
Background
Patients with type 2 intestinal failure (IF) are metabolically unstable and prone to electrolyte derangements. Nevertheless, the data on the prevalence of hypercalcemia in these patients are lacking to date. The aim of this study was therefore to evaluate the prevalence and causes of hypercalcemia in patients with type 2 IF during their first admission to a dedicated IF unit.
Methods
This was a cohort study of patients with a new diagnosis of type 2 IF admitted to a national UK IF Reference Centre between July 1, 2018, and April 31, 2023. Patients with identified hypercalcemia were followed up from their admission until parenteral support cessation or end of the follow-up on December 31, 2024.
Results
Overall, there were 265 patients included in the analysis. In total, 26/265 (9.8%) patients were diagnosed with hypercalcemia during the admission. In most patients, the cause of hypercalcemia was multifactorial with immobilization, dehydration, and presence of calcium in parenteral support being the most common factors. In all cases, hypercalcemia was transient and resolved by the end of patient admission with continuous optimization of hydration, reduction in supplemented calcium, and/or improved patient mobility. Notably, 11/26 (45.8%) patients with transient inpatient hypercalcemia remained on calcium-free parenteral support after hospital discharge.
Conclusion
Hypercalcemia is present in almost 10% of all admissions with type 2 IF and is multifactorial in origin. Care should be undertaken to optimize patient hydration, parenteral support prescription, and mobilization in the acute hospital setting, with ongoing assessment of calcium requirements following discharge.
{"title":"Hypercalcemia in patients with type 2 intestinal failure receiving parenteral support: A descriptive cohort study","authors":"Maja Kopczynska MBBCh, Thaksala Uduvawidana MD, Simon Harrison MPharm, Sorrel Burden PhD, Gordon L. Carlson PhD, Simon Lal PhD","doi":"10.1002/jpen.70005","DOIUrl":"10.1002/jpen.70005","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients with type 2 intestinal failure (IF) are metabolically unstable and prone to electrolyte derangements. Nevertheless, the data on the prevalence of hypercalcemia in these patients are lacking to date. The aim of this study was therefore to evaluate the prevalence and causes of hypercalcemia in patients with type 2 IF during their first admission to a dedicated IF unit.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a cohort study of patients with a new diagnosis of type 2 IF admitted to a national UK IF Reference Centre between July 1, 2018, and April 31, 2023. Patients with identified hypercalcemia were followed up from their admission until parenteral support cessation or end of the follow-up on December 31, 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, there were 265 patients included in the analysis. In total, 26/265 (9.8%) patients were diagnosed with hypercalcemia during the admission. In most patients, the cause of hypercalcemia was multifactorial with immobilization, dehydration, and presence of calcium in parenteral support being the most common factors. In all cases, hypercalcemia was transient and resolved by the end of patient admission with continuous optimization of hydration, reduction in supplemented calcium, and/or improved patient mobility. Notably, 11/26 (45.8%) patients with transient inpatient hypercalcemia remained on calcium-free parenteral support after hospital discharge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Hypercalcemia is present in almost 10% of all admissions with type 2 IF and is multifactorial in origin. Care should be undertaken to optimize patient hydration, parenteral support prescription, and mobilization in the acute hospital setting, with ongoing assessment of calcium requirements following discharge.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 8","pages":"1021-1027"},"PeriodicalIF":4.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mengxin Zhang MM, Bo Li MM, Yuesheng Gong BM, Lei Dong PhD
{"title":"Energy and protein intake adequacy in geriatric rehabilitation inpatients: A descriptive cohort study","authors":"Mengxin Zhang MM, Bo Li MM, Yuesheng Gong BM, Lei Dong PhD","doi":"10.1002/jpen.70007","DOIUrl":"10.1002/jpen.70007","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"JPEN Journal Club 95. Pursuing truth with P values","authors":"Ronald L. Koretz MD","doi":"10.1002/jpen.70006","DOIUrl":"10.1002/jpen.70006","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 2","pages":"261-263"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amy Gates PhD, Sarah D. Maria MS, Nathan A. Meredith PhD, Thomas Houslay PhD, Brian K. Stansfield MD
Background
We aimed to analyze vitamin A content in pooled donor human milk (DHM) and determine enteral vitamin A intake after fortification (NCT05742815).
Methods
We analyzed pooled DHM (n = 15) from seven commercial milk banks for vitamin A (retinol) content. Retinol was directly quantified by ultra-high–performance liquid chromatography. Enteral retinol intake was calculated for several commercial liquid human milk fortifiers (HMFs) at standard fortification according to each manufacturer's instructions.
Results
The mean retinol concentration in commercial DHM was 120 ± 30 international units (IU)/dl (range, 49–158 IU/dl). Retinol content correlated with fat content in DHM (R2 = 0.37; P = 0.01). Standard fortification of DHM with HMF (150 ml/kg/day; 24 kcal/ounce) results in variable enteral retinol intake (range, 200–1600 IU/kg/day).
Conclusion
Vitamin A content in DHM approximates mature term human milk, but vitamin A intake may be insufficient for some preterm infants provided an exclusive human milk diet.
背景：我们旨在分析混合供乳（DHM）中维生素A的含量，并测定强化后肠内维生素A的摄入量（NCT05742815）。方法：对7家商业母乳库中15份DHM的维生素A（视黄醇）含量进行分析。采用高效液相色谱法对视黄醇进行定量分析。根据每个制造商的说明，计算了几种商业液体人乳强化剂（HMFs）在标准强化下的肠内视黄醇摄入量。结果：市售丹参中视黄醇平均浓度为120±30国际单位(IU)/dl（范围49 ~ 158 IU/dl）。DHM中视黄醇含量与脂肪含量相关（R2 = 0.37; P = 0.01）。用HMF标准强化DHM（150毫升/公斤/天；24千卡/盎司）会导致不同的肠内视黄醇摄入量（范围，200-1600 IU/公斤/天）。结论：DHM中维生素A的含量与足月人乳相近，但在纯母乳喂养的情况下，某些早产儿维生素A的摄入量可能不足。
{"title":"Vitamin A in donor human milk: An experimental study","authors":"Amy Gates PhD, Sarah D. Maria MS, Nathan A. Meredith PhD, Thomas Houslay PhD, Brian K. Stansfield MD","doi":"10.1002/jpen.70008","DOIUrl":"10.1002/jpen.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We aimed to analyze vitamin A content in pooled donor human milk (DHM) and determine enteral vitamin A intake after fortification (NCT05742815).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed pooled DHM (<i>n</i> = 15) from seven commercial milk banks for vitamin A (retinol) content. Retinol was directly quantified by ultra-high–performance liquid chromatography. Enteral retinol intake was calculated for several commercial liquid human milk fortifiers (HMFs) at standard fortification according to each manufacturer's instructions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean retinol concentration in commercial DHM was 120 ± 30 international units (IU)/dl (range, 49–158 IU/dl). Retinol content correlated with fat content in DHM (<i>R</i><sup>2</sup> = 0.37; <i>P</i> = 0.01). Standard fortification of DHM with HMF (150 ml/kg/day; 24 kcal/ounce) results in variable enteral retinol intake (range, 200–1600 IU/kg/day).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Vitamin A content in DHM approximates mature term human milk, but vitamin A intake may be insufficient for some preterm infants provided an exclusive human milk diet.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 8","pages":"951-954"},"PeriodicalIF":4.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiaohua Ai MD, Yuchun Deng RN, Bolan Wang RN, Hua Deng RN, Dongmei Tang RN, Linying Zeng RN, Yuping Jin RN, Yurong Liu RN, Lingli Jia RN
Background
Oral mucosal membrane pressure injuries are common yet underrecognized complications in critically ill patients with endotracheal tubes. This study investigated the association between nutrition risk and oral mucosal membrane pressure injuries.
Methods
This multicenter prospective cohort study enrolled 1533 intensive care unit patients with endotracheal tubes between April and December 2023. The primary model examined the association between nutrition risk and oral mucosal membrane pressure injuries. Additional analyses evaluated associations of medical nutrition therapy and inflammatory biomarkers (procalcitonin and C-reactive protein) with the outcome. Cox proportional hazards regression models were used, and five sequential models adjusted for confounders.
Results
Overall, 551 patients (36.3%) developed oral mucosal membrane pressure injuries. Nutrition risk was independently associated with an increased risk (hazard ratio [HR] = 1.37; 95% CI, 1.07–1.75). Medical nutrition therapy, including enteral nutrition, parenteral nutrition, and combined therapy, was associated with a reduced risk compared with suspended diet, with longer durations conferring greater benefit (HR = 0.77; 95% CI, 0.74–0.80). Additionally, elevated procalcitonin levels were associated with an increased risk of oral mucosal membrane pressure injuries (HR = 1.35; 95% CI, 1.09–1.68), whereas high C-reactive protein levels, although not statistically significant (HR = 1.09; 95% CI, 0.91–1.30), suggested a potential promoting effect.
Conclusion
Nutrition risk was an independent risk factor for oral mucosal membrane pressure injuries in critically ill patients with endotracheal tubes. Medical nutrition therapy reduced this risk, particularly with longer durations. Additionally, elevated procalcitonin levels were associated with a higher risk, highlighting the role of inflammation in pressure injury development.
{"title":"Association between nutrition risk and oral mucosal membrane pressure injury in critically ill adults requiring endotracheal tube placement: A prospective cohort study","authors":"Xiaohua Ai MD, Yuchun Deng RN, Bolan Wang RN, Hua Deng RN, Dongmei Tang RN, Linying Zeng RN, Yuping Jin RN, Yurong Liu RN, Lingli Jia RN","doi":"10.1002/jpen.70004","DOIUrl":"10.1002/jpen.70004","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral mucosal membrane pressure injuries are common yet underrecognized complications in critically ill patients with endotracheal tubes. This study investigated the association between nutrition risk and oral mucosal membrane pressure injuries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multicenter prospective cohort study enrolled 1533 intensive care unit patients with endotracheal tubes between April and December 2023. The primary model examined the association between nutrition risk and oral mucosal membrane pressure injuries. Additional analyses evaluated associations of medical nutrition therapy and inflammatory biomarkers (procalcitonin and C-reactive protein) with the outcome. Cox proportional hazards regression models were used, and five sequential models adjusted for confounders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 551 patients (36.3%) developed oral mucosal membrane pressure injuries. Nutrition risk was independently associated with an increased risk (hazard ratio [HR] = 1.37; 95% CI, 1.07–1.75). Medical nutrition therapy, including enteral nutrition, parenteral nutrition, and combined therapy, was associated with a reduced risk compared with suspended diet, with longer durations conferring greater benefit (HR = 0.77; 95% CI, 0.74–0.80). Additionally, elevated procalcitonin levels were associated with an increased risk of oral mucosal membrane pressure injuries (HR = 1.35; 95% CI, 1.09–1.68), whereas high C-reactive protein levels, although not statistically significant (HR = 1.09; 95% CI, 0.91–1.30), suggested a potential promoting effect.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Nutrition risk was an independent risk factor for oral mucosal membrane pressure injuries in critically ill patients with endotracheal tubes. Medical nutrition therapy reduced this risk, particularly with longer durations. Additionally, elevated procalcitonin levels were associated with a higher risk, highlighting the role of inflammation in pressure injury development.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 8","pages":"983-992"},"PeriodicalIF":4.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aspenjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johannes Hilberath MD, Andreas Busch MD, Ulrich Schoppmeier PhD, Kristina Schmauder MD, Philipp Oberhettinger MD, Matthias Marschal MD, Christoph Slavetinsky MD, PhD, Ekkehard Sturm MD, PhD, Silke Peter MD, Paul D'Alvise PhD
Background
Small intestinal bacterial overgrowth (SIBO) is a clinical and diagnostic challenge in pediatric intestinal failure. This study aimed to assess SIBO and dysbiosis in children with intestinal failure and to analyze clinical characteristics as well as cultural and metagenomic sequencing results from different sampling methods.
Methods
Descriptive, single-center cohort study in intestinal failure patients with prospective collection of intraluminal aspirate, epithelial brush swab, mucosal biopsy, and small bowel stoma stool for SIBO diagnosis, defined as ≥103 CFU/ml of enteric, colonic-type bacteria, and microbiome analysis via whole-genome sequencing. Statistical testing included receiver operating characteristic analysis, chi-square test, and independent samples t test.
Results
Forty-four children with intestinal failure were analyzed (median age 58 months; female 48%; short bowel syndrome 70%). Sixty-six percent of samples were positive for SIBO. In 93%, all three endoscopic sampling methods showed congruent results. SIBO-positive cases were associated (P < 0.05) with small bowel dilatation, proton pump inhibitor use, intestinal inflammation, elevated direct bilirubin and hepatocellular enzyme levels, and a history of liver fibrosis and central venous catheter infections. Metagenomic sequencing revealed microbial dysbiosis in intestinal failure patients, with SIBO-positive cases showing higher microbial reads, lower alpha diversity, and increased abundance of Enterobacteriaceae and enteric anaerobes.
Conclusion
SIBO and dysbiosis are common in children with intestinal failure and associated with liver injury, central line–associated bloodstream infections, and intestinal inflammation. Cultural diagnosis of SIBO using mucosal biopsies or brush swabs are alternatives to small bowel aspirates. Metagenomic sequencing is feasible, and high microbial read numbers are indicative of SIBO.
{"title":"Small intestinal bacterial overgrowth and dysbiosis in children with intestinal failure: A descriptive cohort study","authors":"Johannes Hilberath MD, Andreas Busch MD, Ulrich Schoppmeier PhD, Kristina Schmauder MD, Philipp Oberhettinger MD, Matthias Marschal MD, Christoph Slavetinsky MD, PhD, Ekkehard Sturm MD, PhD, Silke Peter MD, Paul D'Alvise PhD","doi":"10.1002/jpen.2808","DOIUrl":"10.1002/jpen.2808","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Small intestinal bacterial overgrowth (SIBO) is a clinical and diagnostic challenge in pediatric intestinal failure. This study aimed to assess SIBO and dysbiosis in children with intestinal failure and to analyze clinical characteristics as well as cultural and metagenomic sequencing results from different sampling methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Descriptive, single-center cohort study in intestinal failure patients with prospective collection of intraluminal aspirate, epithelial brush swab, mucosal biopsy, and small bowel stoma stool for SIBO diagnosis, defined as ≥10<sup>3</sup> CFU/ml of enteric, colonic-type bacteria, and microbiome analysis via whole-genome sequencing. Statistical testing included receiver operating characteristic analysis, chi-square test, and independent samples <i>t</i> test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-four children with intestinal failure were analyzed (median age 58 months; female 48%; short bowel syndrome 70%). Sixty-six percent of samples were positive for SIBO. In 93%, all three endoscopic sampling methods showed congruent results. SIBO-positive cases were associated (<i>P</i> < 0.05) with small bowel dilatation, proton pump inhibitor use, intestinal inflammation, elevated direct bilirubin and hepatocellular enzyme levels, and a history of liver fibrosis and central venous catheter infections. Metagenomic sequencing revealed microbial dysbiosis in intestinal failure patients, with SIBO-positive cases showing higher microbial reads, lower alpha diversity, and increased abundance of Enterobacteriaceae and enteric anaerobes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SIBO and dysbiosis are common in children with intestinal failure and associated with liver injury, central line–associated bloodstream infections, and intestinal inflammation. Cultural diagnosis of SIBO using mucosal biopsies or brush swabs are alternatives to small bowel aspirates. Metagenomic sequencing is feasible, and high microbial read numbers are indicative of SIBO.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 8","pages":"964-974"},"PeriodicalIF":4.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aspenjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2808","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhihao Zhao MM, Diya Qi MM, Fengyun Zhang MD, Ying Gao MM
Background
The composite dietary antioxidant index (CDAI) is a useful tool for evaluating antioxidant consumption and has been shown to effectively lower the risk of age-related diseases. However, the exact relationship between the CDAI and vascular age has yet to be established.
Methods
We performed a cross-sectional study examining the association between dietary antioxidants, as measured by the CDAI, and estimated pulse wave velocity (ePWV) and heart vascular age in 41,380 adults based in the United States using data from the National Health and Nutrition Examination Survey from 1999 to 2018. Multivariable linear regression models, restricted cubic splines, and subgroup analysis were used to examine the associations between the CDAI and ePWV and heart vascular age.
Results
This study included 41,380 participants with a mean ± SD age of 50 ± 18 years. After adjusting for confounding factors, multiple linear regression analysis revealed that higher CDAI scores were independently associated with lower ePWV (β = −0.008, P < 0.001) and lower heart vascular age (β = −0.080, P = 0.033). Restricted cubic spline analysis showed that the CDAI was negatively associated with ePWV and heart vascular age. No statistical interaction was observed within any subgroups of the CDAI and ePWV and heart vascular age.
Conclusion
Higher CDAI scores were associated with lower ePWV and heart vascular age in US adults.
{"title":"Association between the composite dietary antioxidant index and vascular age among United States adults: A cross-sectional study","authors":"Zhihao Zhao MM, Diya Qi MM, Fengyun Zhang MD, Ying Gao MM","doi":"10.1002/jpen.70001","DOIUrl":"10.1002/jpen.70001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The composite dietary antioxidant index (CDAI) is a useful tool for evaluating antioxidant consumption and has been shown to effectively lower the risk of age-related diseases. However, the exact relationship between the CDAI and vascular age has yet to be established.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a cross-sectional study examining the association between dietary antioxidants, as measured by the CDAI, and estimated pulse wave velocity (ePWV) and heart vascular age in 41,380 adults based in the United States using data from the National Health and Nutrition Examination Survey from 1999 to 2018. Multivariable linear regression models, restricted cubic splines, and subgroup analysis were used to examine the associations between the CDAI and ePWV and heart vascular age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study included 41,380 participants with a mean ± SD age of 50 ± 18 years. After adjusting for confounding factors, multiple linear regression analysis revealed that higher CDAI scores were independently associated with lower ePWV (β = −0.008, <i>P</i> < 0.001) and lower heart vascular age (β = −0.080, <i>P</i> = 0.033). Restricted cubic spline analysis showed that the CDAI was negatively associated with ePWV and heart vascular age. No statistical interaction was observed within any subgroups of the CDAI and ePWV and heart vascular age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Higher CDAI scores were associated with lower ePWV and heart vascular age in US adults.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 8","pages":"1012-1020"},"PeriodicalIF":4.1,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tatucu-Babet OA, King SJ, Zhang AY, et al. Measured energy expenditure according to the phases of critical illness: a descriptive cohort study. J Parenter Enteral Nutr. 2025;49(3):314-323. doi:10.1002/jpen.2721
In the abstract, results, and conclusion, we erroneously described the energy expenditure in our cohort as corresponding to a median [interquartile range] of 135 [117–155]% increase above the predicted basal metabolic rate.
However, the correct description is that measured energy expenditure corresponded to a median [interquartile range] of 135 [117–155]% of the predicted basal metabolic rate, meaning it was a median of 35% above the predicted value.
We apologize for this error.
塔图库-巴贝特OA， King SJ，张艾，等。根据危重疾病阶段测量能量消耗：一项描述性队列研究。[J]中华儿科杂志，2015;49(3):314-323。doi: 10.1002 / jpen。2721在摘要、结果和结论中，我们错误地将我们队列中的能量消耗描述为高于预测基础代谢率的中位数[四分位数范围]增加了135[117-155]%。然而，正确的描述是，测量的能量消耗对应于预测基础代谢率的中位数[四分位数范围]为135[117-155]%，这意味着它比预测值高35%。我们为这个错误道歉。
{"title":"Correction to “Measured energy expenditure according to the phases of critical illness: A descriptive cohort study”","authors":"","doi":"10.1002/jpen.70003","DOIUrl":"10.1002/jpen.70003","url":null,"abstract":"<p>Tatucu-Babet OA, King SJ, Zhang AY, et al. Measured energy expenditure according to the phases of critical illness: a descriptive cohort study. <i>J Parenter Enteral Nutr</i>. 2025;49(3):314-323. doi:10.1002/jpen.2721</p><p>In the abstract, results, and conclusion, we erroneously described the energy expenditure in our cohort as corresponding to a median [interquartile range] of 135 [117–155]% increase above the predicted basal metabolic rate.</p><p>However, the correct description is that measured energy expenditure corresponded to a median [interquartile range] of 135 [117–155]% of the predicted basal metabolic rate, meaning it was a median of 35% above the predicted value.</p><p>We apologize for this error.</p>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 7","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aspenjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing Z, Zhengli J, Ying S, et al. Variations in adverse events associated with different infusion modalities of parenteral nutrition: a pharmacovigilance study. J Parenter Enteral Nutr. 2025; 49(5):659–669. doi:10.1002/jpen.2763
In the article cited above, extraneous text was included in the AUTHOR CONTRIBUTIONS section. The corrected section is reprinted below.
AUTHOR CONTRIBUTIONS
Zhou Jing contributed to the conceptualization, methodology, project administration, review and editing, and investigation. Jiang Zhengli contributed to the software, data curation, formal analysis, methodology, and review and editing. Su Ying contributed to the software, data curation, and visualization. Man Shiyu contributed to the software, data curation, and visualization. Ma Jingjing contributed to the validation and formal analysis. Pang Mujuan contributed to the validation and formal analysis. Xu Hongyan contributed to the validation and visualization. Hu Yan contributed to the conceptualization, original draft, project administration, supervision, and resources.
{"title":"Correction to “Variations in adverse events associated with different infusion modalities of parenteral nutrition: A pharmacovigilance study”","authors":"","doi":"10.1002/jpen.70002","DOIUrl":"10.1002/jpen.70002","url":null,"abstract":"<p>Jing Z, Zhengli J, Ying S, et al. Variations in adverse events associated with different infusion modalities of parenteral nutrition: a pharmacovigilance study. <i>J Parenter Enteral Nutr</i>. 2025; 49(5):659–669. doi:10.1002/jpen.2763</p><p>In the article cited above, extraneous text was included in the AUTHOR CONTRIBUTIONS section. The corrected section is reprinted below.</p><p>AUTHOR CONTRIBUTIONS</p><p>Zhou Jing contributed to the conceptualization, methodology, project administration, review and editing, and investigation. Jiang Zhengli contributed to the software, data curation, formal analysis, methodology, and review and editing. Su Ying contributed to the software, data curation, and visualization. Man Shiyu contributed to the software, data curation, and visualization. Ma Jingjing contributed to the validation and formal analysis. Pang Mujuan contributed to the validation and formal analysis. Xu Hongyan contributed to the validation and visualization. Hu Yan contributed to the conceptualization, original draft, project administration, supervision, and resources.</p><p>We apologize for this error.</p>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 7","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aspenjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"JPEN Journal Club 94. Qualitative systematic reviews","authors":"Ronald L. Koretz MD","doi":"10.1002/jpen.70000","DOIUrl":"10.1002/jpen.70000","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"50 1","pages":"131-133"},"PeriodicalIF":4.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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