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Implementation of Placental Growth Factor in a Tertiary Western Canadian Centre: Association with Ultrasound Findings and Perinatal Outcomes 胎盘生长因子(PlGF)在加拿大西部三级中心的实施:与超声结果和围产期结局的关系。
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-09-11 DOI: 10.1016/j.jogc.2025.103120
Ernesto A. Figueiro-Filho MD, PhD, Genevieve Dietrich HBSc, MEng, Adrielle P. Souza Lira BSN, RN, Eman Ramadan MD, Adewumi Adanlawo MD, John Matelski MSc, Joshua D. Buse PhD

Objectives

This study aimed to evaluate the association between placental growth factor (PlGF) levels, ultrasound findings, and perinatal outcomes in a high-risk pregnant population at a tertiary referral centre in Western Canada, and to assess the predictive performance of the PlGF test.

Methods

We conducted a retrospective cohort study of 389 high-risk pregnant individuals who underwent PlGF testing between 120 and 360 weeks gestation. Participants were stratified by PlGF level: normal (≥10th centile), inconclusive (5th–9th centile), and low (≤5th centile). Clinical, biochemical, ultrasound, and perinatal outcomes were compared across groups. Odds ratios, sensitivity, specificity, and predictive values were calculated.

Results

Low PlGF levels were observed in 33.9% of pregnancies, with testing performed at a median gestational age of 276 weeks. Low PlGF levels were significantly associated with higher maternal BMI, elevated blood pressure, and increased creatinine, uric acid, and proteinuria levels. Ultrasound findings in the low PlGF group revealed higher rates of fetal growth restriction, abnormal Doppler studies, and abnormal placental morphology. These pregnancies had increased incidence of preterm birth <340 weeks (52/132; 39.3%), preeclampsia (69/132; 52.3%), neonatal intensive care unit admission (54/132; 40.9%), and small-for-gestational-age neonates (15/132; 11.4%). Most negative predictive values exceeded 90%.

Conclusions

Low maternal PlGF levels are strongly associated with ultrasound and biochemical indicators of placental dysfunction and adverse perinatal outcomes. PlGF testing may serve as an effective risk stratification tool in high-risk pregnancies, particularly in rural and underserved populations.
目的:评估加拿大西部三级转诊中心高危妊娠人群中胎盘生长因子(PlGF)水平、超声表现和围产期结局之间的关系,并评估PlGF检测的预测性能。方法:我们对389例妊娠12+0 ~ 36+0周间接受PlGF检测的高危孕妇进行了回顾性队列研究。参与者按PlGF水平分层:正常(≥10百分位)、不确定(5 -9百分位)和低(≤5百分位)。比较各组临床、生化、超声和围产期结局。计算比值比、敏感性、特异性和预测值。结果:低PlGF水平在33.9%的妊娠中被观察到,在中位胎龄为27.7周时进行检测。低PlGF水平与母亲较高的BMI、血压升高、肌酐、尿酸和蛋白尿水平升高显著相关。低PlGF组的超声检查结果显示胎儿生长受限率较高,多普勒检查异常,胎盘形态异常。结论:低PlGF水平与超声及胎盘功能障碍生化指标及不良围产期结局密切相关。PlGF检测可作为高危妊娠的有效风险分层工具,特别是在农村和服务不足的人群中。
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引用次数: 0
Guideline No. 464: Recurrent Pregnancy Loss 指南第464号:复发性妊娠丢失。
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI: 10.1016/j.jogc.2025.103167
Tarek Motan MD, Heather Cockwell MD, Jason Elliott MD, Roland Antaki MD, Justin White MD
<div><h3>Objective</h3><div>The object of this guideline is to provide clinicians with the most up to date evidence available for the evaluation and management of patients with recurrent pregnancy loss.</div></div><div><h3>Target Population</h3><div>Patients with Recurrent Pregnancy Loss (defined as two or more pregnancy losses.)</div></div><div><h3>Options</h3><div>Strategies for managing RPL includes lifestyle changes (reducing caffeine, smoking, alcohol), addressing obesity, screening for thyroid dysfunction, diabetes, antiphospholipid syndrome, and treating uterine anomalies like septate uterus or adhesions. Chronic endometritis may benefit from antibiotics. Genetic testing of gestational tissue and parental karyotyping can identify chromosomal issues. Treating acquired thrombophilias may be beneficial. Progesterone therapy may be helpful, especially if started in the luteal phase. Access to early pregnancy assessment clinics, emotional support, close monitoring, and trauma-informed care are essential, with empirical treatments used cautiously due to limited evidence.</div></div><div><h3>Outcomes</h3><div>Pregnancy loss rate, Live birth rate</div></div><div><h3>Benefits, Harms, and Costs</h3><div>Improved live birth rates and providing etiological answers to affected patients. Patients will sacrifice time and experience the discomfort of investigations with a high probability of negative results. The financial costs of investigations are covered by medical plans, but some of the therapies are uninsured and expensive. Investigations should be done according to evidence-based recommendations and accessible to all women.</div></div><div><h3>Evidence</h3><div>English-language articles were searched from January 1, 2008 to June 30, 2025 in PubMed, Cochrane Library, CINAHL, MEDLINE, Embase and Scopus using the broad search terms habitual abortion, abortion, recurrent abortion, recurrent miscarriage, recurrent early pregnancy loss, recurrent pregnancy loss, idiopathic pregnancy loss, idiopathic recurrent miscarriage.</div></div><div><h3>Validation Methods</h3><div>The authors rated the quality of evidence and strength of recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. See online <span><span>Appendix A</span></span> (<span><span>Tables A1</span></span> for definitions and <span><span>A2</span></span> for interpretations of strong and conditional [weak] recommendations).</div></div><div><h3>Intended Audience</h3><div>All healthcare professionals who care for patients with Recurrent Pregnancy Loss.</div></div><div><h3>Abstract for social media</h3><div>Recurrent Pregnancy Loss (RPL) is defined as two or more pregnancy losses, including non-consecutive and biochemical. Causes range from chromosomal and anatomical to endocrine, immune, infectious, and lifestyle factors—though most remain unexplained. Evaluation and personalized care are essential. While evidence for treatments varies, trauma-i
*目的:本指南的目的是为临床医生提供最新的证据,用于评估和管理复发性妊娠丢失患者。*目标人群:复发性妊娠丢失患者(定义为两次或两次以上妊娠丢失)。治疗RPL的策略包括改变生活方式(减少咖啡因,吸烟,饮酒),解决肥胖问题,筛查甲状腺功能障碍,糖尿病,抗磷脂综合征,治疗子宫异常,如分隔子宫或粘连。慢性子宫内膜炎可能受益于抗生素。妊娠组织的基因检测和亲本染色体组型可以确定染色体问题。治疗获得性血栓患者可能是有益的。黄体酮治疗可能有帮助,特别是在黄体期开始。获得早期妊娠评估诊所、情感支持、密切监测和创伤知情护理是必不可少的,由于证据有限,应谨慎使用经验性治疗。结果:流产率、活产率*益处、危害和成本:提高活产率并为受影响患者提供病因学答案。患者将牺牲时间,并经历调查的不适与高概率的阴性结果。调查的财务费用由医疗计划支付,但有些治疗没有保险,而且费用昂贵。调查应根据基于证据的建议进行,并向所有妇女开放。*证据:从2008年1月1日至2025年6月30日在PubMed、Cochrane Library、CINAHL、MEDLINE、Embase和Scopus中检索英语文章,使用广泛的搜索词习惯性流产、流产、复发性流产、复发性流产、复发性早期妊娠丢失、复发性妊娠丢失、特发性妊娠丢失、特发性复发性流产。*验证方法:作者使用分级推荐评估、发展和评价(GRADE)方法对证据质量和推荐的强度进行评级。参见在线附录A(表A1为定义,表A2为强建议和条件[弱]建议的解释)。*目标受众:所有护理复发性妊娠丢失患者的医疗保健专业人员。*社交媒体摘要:复发性妊娠丢失(RPL)定义为两次或两次以上的妊娠丢失,包括非连续和生化。病因包括从染色体和解剖学到内分泌、免疫、感染和生活方式等因素,尽管大多数原因仍无法解释。评估和个性化护理是必不可少的。虽然治疗的证据各不相同,但在全国范围内,创伤知情护理、共同决策和公平获得调查至关重要。
{"title":"Guideline No. 464: Recurrent Pregnancy Loss","authors":"Tarek Motan MD,&nbsp;Heather Cockwell MD,&nbsp;Jason Elliott MD,&nbsp;Roland Antaki MD,&nbsp;Justin White MD","doi":"10.1016/j.jogc.2025.103167","DOIUrl":"10.1016/j.jogc.2025.103167","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;The object of this guideline is to provide clinicians with the most up to date evidence available for the evaluation and management of patients with recurrent pregnancy loss.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Target Population&lt;/h3&gt;&lt;div&gt;Patients with Recurrent Pregnancy Loss (defined as two or more pregnancy losses.)&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Options&lt;/h3&gt;&lt;div&gt;Strategies for managing RPL includes lifestyle changes (reducing caffeine, smoking, alcohol), addressing obesity, screening for thyroid dysfunction, diabetes, antiphospholipid syndrome, and treating uterine anomalies like septate uterus or adhesions. Chronic endometritis may benefit from antibiotics. Genetic testing of gestational tissue and parental karyotyping can identify chromosomal issues. Treating acquired thrombophilias may be beneficial. Progesterone therapy may be helpful, especially if started in the luteal phase. Access to early pregnancy assessment clinics, emotional support, close monitoring, and trauma-informed care are essential, with empirical treatments used cautiously due to limited evidence.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Outcomes&lt;/h3&gt;&lt;div&gt;Pregnancy loss rate, Live birth rate&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Benefits, Harms, and Costs&lt;/h3&gt;&lt;div&gt;Improved live birth rates and providing etiological answers to affected patients. Patients will sacrifice time and experience the discomfort of investigations with a high probability of negative results. The financial costs of investigations are covered by medical plans, but some of the therapies are uninsured and expensive. Investigations should be done according to evidence-based recommendations and accessible to all women.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Evidence&lt;/h3&gt;&lt;div&gt;English-language articles were searched from January 1, 2008 to June 30, 2025 in PubMed, Cochrane Library, CINAHL, MEDLINE, Embase and Scopus using the broad search terms habitual abortion, abortion, recurrent abortion, recurrent miscarriage, recurrent early pregnancy loss, recurrent pregnancy loss, idiopathic pregnancy loss, idiopathic recurrent miscarriage.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Validation Methods&lt;/h3&gt;&lt;div&gt;The authors rated the quality of evidence and strength of recommendations using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. See online &lt;span&gt;&lt;span&gt;Appendix A&lt;/span&gt;&lt;/span&gt; (&lt;span&gt;&lt;span&gt;Tables A1&lt;/span&gt;&lt;/span&gt; for definitions and &lt;span&gt;&lt;span&gt;A2&lt;/span&gt;&lt;/span&gt; for interpretations of strong and conditional [weak] recommendations).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Intended Audience&lt;/h3&gt;&lt;div&gt;All healthcare professionals who care for patients with Recurrent Pregnancy Loss.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Abstract for social media&lt;/h3&gt;&lt;div&gt;Recurrent Pregnancy Loss (RPL) is defined as two or more pregnancy losses, including non-consecutive and biochemical. Causes range from chromosomal and anatomical to endocrine, immune, infectious, and lifestyle factors—though most remain unexplained. Evaluation and personalized care are essential. While evidence for treatments varies, trauma-i","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":"47 12","pages":"Article 103167"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145427248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of an Obstetric Medicine Curriculum for Obstetrics and Gynecology Trainees: A Quality Improvement Study 妇产科培训生产科医学课程评价:质量改进研究。
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-09-10 DOI: 10.1016/j.jogc.2025.103116
Kelsey MacEachern BMSc, MD , Katherine Steckham MD , Michelle Morais BSc, MD, DRCPSC , Serena Gundy MD , Amanda Huynh MD, MSc QIPS

Objectives

Medical disorders in pregnancy are increasing. This highlights the need for obstetrics trainees to develop a strong foundation in managing medical conditions in pregnancy.

Methods

To address this, the internal medicine curriculum at our institution was redesigned for first year obstetrics residents to include an obstetric medicine (OBM) rotation.

Results

Before implementation, only 19% of residents felt at least moderately comfortable with OBM topics outlined by the Canadian Consensus for a Curriculum in Obstetric Medicine. This increased to 66% after the introduction of the redesigned curriculum. Using quality improvement methodology, we aimed to increase this to 80% via iterative plan-do-study-act cycles. Post-intervention, 81% of trainees reported feeling at least moderately comfortable in 14 of 17 Canadian Consensus for a Curriculum in Obstetric Medicine topics.

Conclusions

This quality improvement–driven curriculum enhancement was well-received and further highlights the value of early OBM integration in obstetrics training.
目的:妊娠期医学障碍日益增多。这突出表明,产科培训生需要在管理妊娠医疗条件方面打下坚实的基础。方法:为了解决这个问题,我们机构重新设计了第一年产科住院医师的内科课程,包括产科医学(OBM)轮转。结果:在实施之前,只有19%的居民对加拿大产科医学课程共识(CanCOM)概述的产科医学主题感到至少适度舒适。引入重新设计的课程后,这一比例增加到66%。使用质量改进(QI)方法,我们的目标是通过迭代的计划-执行-研究-行动循环将这一比例提高到80%。干预后,81%的受训者报告在17个CanCOM主题中的14个中至少感到适度舒适。结论:以qi为导向的课程改进效果良好,进一步凸显了早期产科医学整合在产科培训中的价值。
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引用次数: 0
Trans Peoples’ Interest in Reproduction and Fertility Preservation: A Cross-Sectional, Descriptive Study Into Barriers to Reproductive Care 跨性别人群对生殖和生育保护的兴趣:对生殖保健障碍的横断面描述性研究。
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1016/j.jogc.2025.103125
Lara Des Roches MD, MSc, BScN, Bianca Ziegler MD, MSc, BHSc, Stacy Deniz MD

Objective

This study aimed to ascertain trans peoples’ interest in reproductive choices. Our secondary objective was to understand barriers to meeting their reproductive goals.

Methods

We conducted a descriptive cross-sectional study using a one-time anonymous survey. Analysis was conducted using descriptive statistics and a thematic analysis using inductive coding.

Results

Analysis of trans participants’ responses revealed 82% (N = 169) of participants are interested in pursuing reproductive options (biologically related children, donor gametes, gestational carriers, or fertility preservation). Sixty-eight percent (N = 172) of participants are taking gender-affirming hormone therapy or plan to start. Forty-nine percent (N = 124) have had or plan to have gender-affirming surgery that affects fertility. Trans folks experience many barriers when accessing fertility care; cost and trans-specific barriers were the most common and insurmountable barriers.

Conclusions

Our study highlights that trans folks are interested in reproductive options. However, many trans people experience significant barriers to meeting their reproductive goals and this significantly impacts their quality of life. With most of our survey population identifying as trans at an age during the window of peak fertility, we highlight the importance of early assessment and treatment to achieve fertility goals.
简介:变性人是一个不断增长的弱势群体。从历史上看,性别确认护理是失去生育选择的同义词。变性和生育保健一直在发展,因此,有必要对当前的生殖兴趣和生殖障碍进行调查。目的:了解跨性别人群对生育选择的兴趣。我们的第二个目标是了解阻碍她们实现生育目标的障碍。方法:采用一次性匿名调查进行描述性横断面研究。采用描述性统计和归纳编码的专题分析方法进行分析。结果:对跨性别参与者的反应分析显示,82% (N = 169)的参与者有兴趣追求生殖选择(生物学上相关的孩子、供体配子、妊娠载体或生育能力保存)。68% (N = 172)的参与者正在接受或计划接受性别确认激素治疗。49% (N = 124)的人已经或计划进行影响生育能力的性别确认手术。跨性别人士在获得生育护理时遇到许多障碍;成本和跨特定障碍是最常见和最难以克服的障碍。结论:我们的研究强调了变性人对生育选择的兴趣。然而,许多跨性别者在实现生育目标方面遇到了重大障碍,这对生活质量产生了重大影响。由于我们的大多数调查人口在生育高峰期的年龄确定为变性人,我们强调早期评估和治疗对实现生育目标的重要性。
{"title":"Trans Peoples’ Interest in Reproduction and Fertility Preservation: A Cross-Sectional, Descriptive Study Into Barriers to Reproductive Care","authors":"Lara Des Roches MD, MSc, BScN,&nbsp;Bianca Ziegler MD, MSc, BHSc,&nbsp;Stacy Deniz MD","doi":"10.1016/j.jogc.2025.103125","DOIUrl":"10.1016/j.jogc.2025.103125","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to ascertain trans peoples’ interest in reproductive choices. Our secondary objective was to understand barriers to meeting their reproductive goals.</div></div><div><h3>Methods</h3><div>We conducted a descriptive cross-sectional study using a one-time anonymous survey. Analysis was conducted using descriptive statistics and a thematic analysis using inductive coding.</div></div><div><h3>Results</h3><div>Analysis of trans participants’ responses revealed 82% (N = 169) of participants are interested in pursuing reproductive options (biologically related children, donor gametes, gestational carriers, or fertility preservation). Sixty-eight percent (N = 172) of participants are taking gender-affirming hormone therapy or plan to start. Forty-nine percent (N = 124) have had or plan to have gender-affirming surgery that affects fertility. Trans folks experience many barriers when accessing fertility care; cost and trans-specific barriers were the most common and insurmountable barriers.</div></div><div><h3>Conclusions</h3><div>Our study highlights that trans folks are interested in reproductive options. However, many trans people experience significant barriers to meeting their reproductive goals and this significantly impacts their quality of life. With most of our survey population identifying as trans at an age during the window of peak fertility, we highlight the importance of early assessment and treatment to achieve fertility goals.</div></div>","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":"47 12","pages":"Article 103125"},"PeriodicalIF":2.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of a Novel Resource Stewardship Curriculum for Residents in Obstetrics and Gynaecology 一种新的妇产科住院医师资源管理课程评估。
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-10-22 DOI: 10.1016/j.jogc.2025.103148
Claire Ann Jones MD , Catherine Friedman MD, HBSc, BScN , Leslie Po MD, MSc , Karen Born MSc, PhD , Heather Shapiro MD , Geetha Mukerji MD, MSc
Obstetrics and Gynaecology residents were randomized into 1 of 2 novel resource stewardship curriculum workshops. Surveys elicited skill, comfort, and clinical behaviours around resource stewardship. Communication skills on resource use were evaluated in an Objective Structured Clinical Exam. The curriculum was favourably rated (4.2 of 5) and clinical behaviours around select resource use issues improved. Skill and comfort were not significantly changed, but there was a trend toward improved Objective Structured Clinical Exam scores in residents attending the communication workshop. Favourable ratings and improved behaviour support inclusion of resource stewardship curricula in Obstetrics and Gynaecology residency programs.
妇产科(OBGYN)住院医师被随机分配到两个新颖的资源管理课程研讨会之一。调查引出了围绕资源管理的技能、舒适和临床行为。通过客观结构化临床检查(OSCE)评估资源使用的沟通技巧。课程得到了好评(5分满分4.2分),围绕选择资源使用问题的临床行为得到了改善。技能和舒适度没有显著变化,但参加交流讲习班的居民的欧安组织得分有提高的趋势。良好的评分和改进的行为支持在妇产科住院医师项目中纳入资源管理课程。
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引用次数: 0
The Effectiveness of Letrozole Adjunct in the Combined Pharmacological and Surgical Treatment of Cesarean Scar Pregnancy: A Prospective Cohort Study 来曲唑辅助药物联合手术治疗剖宫产瘢痕妊娠的有效性:一项前瞻性队列研究。
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-10-31 DOI: 10.1016/j.jogc.2025.103166
Iwona Gawron PhD, MD , Milosz Pietrus PhD, MD , Andrzej Zmaczynski MD , Robert Jach PhD, MD

Objectives

To compare the treatment outcomes of cesarean scar pregnancy (CSP) using a combined pharmacological and surgical approach with and without adjunct letrozole.

Methods

All women received 100 mg of methotrexate intravenously and 50 mg intra-amniotically. The intervention group also received 5 mg of letrozole orally for 10 days. After decreased CSP viability, hysteroscopic evacuation of trophoblastic remnants was performed. Biochemical indicators of efficacy and complications of pharmacotherapy, time interval to surgery, intraoperative blood loss, complications, and subsequent obstetric outcomes were compared across both study arms.

Results

Among 28 women, 16 received letrozole, whereas 12 received only methotrexate. There were no significant differences in serum β-human chorionic gonadotropin (β-hCG), hemoglobin, renal and liver parameters on days 0, 4, and 7 or in intraoperative blood loss, decrease in postoperative hemoglobin, red blood cell concentrate units transfused, uterine tamponade, complications, or obstetric outcomes. The day 0 β-hCG concentration correlated positively with postoperative hemoglobin reduction (P = 0.007), blood loss (P < 0.001), red blood cell concentrate units transfused (P = 0.012), and risk of uterine perforation or hemorrhage (P = 0.043). Cases with a positive fetal heartbeat experienced significantly greater blood loss (P = 0.019) and a higher number of red blood cell concentrate units transfused (P = 0.033).

Conclusions

The incorporation of letrozole in the studied regimen did not impact the final end points. The significant factors influencing intraoperative blood loss and complications were the initial concentration of β-hCG and the presence of a fetal heartbeat. Combined treatment of CSP with methotrexate, followed by hysteroscopy, is a safe method that ensures effective treatment while preserving the uterus.
目的:比较药物和手术联合治疗剖宫产瘢痕妊娠(CSP)的效果,并与不使用来曲唑进行比较。方法:所有妇女均静脉注射甲氨蝶呤100 mg,羊膜内注射甲氨蝶呤50 mg。干预组患者在对照组治疗的基础上口服来曲唑5 mg,疗程10 d。在CSP活力下降后,宫腔镜下进行滋养层残余的清除。比较两个研究组的药物治疗疗效和并发症、手术时间间隔、术中出血量、并发症和随后的产科结局的生化指标。结果:28例妇女中,16例接受来曲唑治疗,12例仅接受甲氨蝶呤治疗。在第0、4、7天的血清β-人绒毛膜促性腺激素(β-hCG)、血红蛋白、肾脏和肝脏参数、术中出血量、术后血红蛋白减少、输血红细胞浓缩单位、子宫填塞、并发症或产科结局方面均无显著差异。第0天β-hCG浓度与术后血红蛋白降低(P = 0.007)、出血量(P < 0.001)、输血红细胞浓缩单位(P = 0.012)、子宫穿孔或出血风险(P = 0.043)呈正相关。胎儿心跳阳性的患者失血量显著增加(P = 0.019),输血红细胞浓度显著增加(P = 0.033)。结论:在研究方案中加入来曲唑对最终终点没有影响。影响术中出血量和并发症的重要因素是β-hCG的初始浓度和胎儿心跳的存在。联合甲氨蝶呤治疗CSP后宫腔镜检查是一种安全的方法,确保有效的治疗,同时保留子宫。
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引用次数: 0
Evaluation of Cesarean Delivery Rates across Ontario from 2012 to 2019 Using the Modified Robson Classification System: A Population-Based Study 使用改进的Robson分类系统评估2012-2019年安大略省剖宫产率:一项基于人群的研究
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.jogc.2025.103131
Sandra I. Dunn RN, BNSc, MEd, MScN, PhD , Yanfang Guo MSc, MB, PhD , Sheryll Dimanlig-Cruz MSc , Malia S.Q. Murphy PhD , Sara Carolina Scremin Souza MSc , Ruth Rennicks White RN, BScN , Deshayne B. Fell MSc, PhD , Shi Wu Wen PhD , Jun Zhang PhD , Mark C. Walker MD, MSc, MSCHM , Darine El-Chaâr MD, MSc

Objectives

This study aimed to describe the trends in cesarean delivery (CD) rates in Ontario using the modified Robson classification system, and identify the most common indications for CD.

Methods

We conducted a population-based retrospective cross-sectional study using data from the Better Outcomes Registry & Network, a comprehensive maternal-child registry in Ontario. The analysis included all pregnant persons who delivered a live- or stillborn infant weighing ≥500 g at ≥200 weeks gestation between April 1, 2012 and March 31, 2019.

Results

A total of 952 567 pregnant persons gave birth in Ontario, Canada, during the study period. Our findings demonstrated a slight increase in the overall CD rate over 7 fiscal years from 2012–2013 to 2018–2019. Robson group 5 (term, singleton, cephalic pregnancy with previous CD), groups 1 and 2 (nulliparous, term, singleton, cephalic pregnancy and no labour, induced labour, or spontaneous labour), and group 6 (nulliparous pregnancy with breech presentation) made the largest contributions to the overall CD rate over the study period. The top 5 primary indications for CD across all years included previous CD, atypical or abnormal fetal surveillance, malposition/malpresentation, non-progressive first stage of labour, and non-progressive second stage of labour.

Conclusions

The results enhance our understanding of the key drivers of CD rates. These findings will help to inform practice improvement, support policy change, and identify areas where future research is needed.
目的:本研究旨在利用改进的Robson分类系统描述安大略省剖宫产率的趋势,并确定剖宫产最常见的适应症。方法:我们进行了一项基于人群的回顾性横断面研究,研究数据来自安大略省的一个综合母婴登记处——更好的结局登记处和网络(BORN)。该分析包括2012年4月1日至2019年3月31日期间妊娠≥20周分娩体重≥500克活产或死产婴儿的所有孕妇。结果:在研究期间,加拿大安大略省共有952 567名孕妇分娩。我们的研究结果表明,从2012-2013年到2018-2019年的七个财政年度,总体CD率略有上升。Robson组5(足月单胎头位妊娠,既往有乳糜泻)、组1和组2(无产、足月、单胎、头位妊娠,无分娩、引产或自然分娩)和组6(无产妊娠,臀位分娩)在研究期间对总乳糜泻率贡献最大。在所有年份中,乳糜泻的前五大主要指征包括既往乳糜泻、非典型或异常胎儿监测、体位/表现不当、第一产程非进行性和第二产程非进行性。结论:研究结果加深了我们对慢性阻塞性肺病发病率的主要影响因素的认识。这些发现将有助于为实践改进提供信息,支持政策变化,并确定未来需要研究的领域。
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引用次数: 0
SARS-CoV-2 Vaccination and Disorders of Menstruation: A Population-Based Cohort Study SARS-CoV-2疫苗接种与月经紊乱:一项基于人群的队列研究
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI: 10.1016/j.jogc.2025.103159
Maria P. Velez MD, PhD , Kensie Treacy BSc , Jonas Shellenberger MSc , Joel G. Ray MD, MSc
This population-based study evaluated the association between SARS-CoV-2 vaccination and disorders of menstruation among all women in Ontario aged 18–44 years. Study exposure was receipt of a first dose of any SARS-CoV-2 vaccine from December 2021 to December 2022, handled in a time-varying manner. The outcome was an incident diagnosis of a disorder of menstruation, defined as 2 medical encounters billed as International Classification of Diseases, Ninth Revision diagnosis code 626 up to December 2023. Included were 2 114 589 women, of whom 44.7% were vaccinated against SARS-CoV-2. Disorders of menstruation occurred at a rate of 15.9 per 1000 person-years among vaccinated women, in contrast to a rate of 26.4 per 1000 person-years among unvaccinated women (adjusted rate ratio 0.60; 95% CI 0.59–0.60), supporting a lack of association between SARS-CoV-2 vaccination and an increased risk of disorders of menstruation.
这项基于人群的研究评估了安大略省所有18-44岁女性接种SARS-CoV-2疫苗与月经紊乱之间的关系。研究暴露是指在2021年12月至2022年12月期间以随时间变化的方式接种任何SARS-CoV-2疫苗的第一剂。结果是对月经紊乱的意外诊断,定义为截至2023年12月的两次医疗就诊,编号为ICD9-626。包括2 114 589名妇女,其中44.7%接种了SARS-CoV-2疫苗。在接种疫苗的妇女中,月经紊乱的发生率为每1000人年15.9例,而未接种疫苗的妇女为每1000人年26.4例(aRR 0.60; 95% CI 0.59至0.60),支持SARS-CoV-2疫苗接种与月经紊乱风险增加之间缺乏关联。
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引用次数: 0
Ligne directrice n° 464 : Fausses couches à répétition 指南464:重复流产。
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-11-07 DOI: 10.1016/j.jogc.2025.103168
Tarek Motan MD, Heather Cockwell MD, Jason Elliott MD, Roland Antaki MD, Justin White MD
<div><h3>Objectif</h3><div>L'objectif de cette ligne directrice est de fournir aux professionnels de santé les données probantes les plus récentes disponibles pour l'évaluation et la prise en charge des patientes souffrant de fausses couches à répétition.</div></div><div><h3>Population cible</h3><div>Les patientes présentant des fausses couches à répétition, définies comme deux fausses couches ou plus.</div></div><div><h3>Options</h3><div>Les stratégies de prise en charge des FCR comprennent des changements de mode de vie (réduction de la consommation de caféine, de tabac et d'alcool), la lutte contre l'obésité, le dépistage des dysfonctionnements thyroïdiens, du diabète et du syndrome des antiphospholipides, ainsi que le traitement des anomalies utérines telles que l'utérus cloisonné(septé) ou les adhérences (synéchies) intrautérines. Les antibiotiques peuvent être bénéfiques en cas d'endométrite chronique. L’analyse génétique des produits de conceptions et le caryotypage parental permettent d'identifier les problèmes chromosomiques. Le traitement des thrombophilies acquises peut être bénéfique. Un traitement à la progestérone peut être utile, en particulier s'il est commencé pendant la phase lutéale. L'accès à des cliniques d'évaluation précoce de la grossesse, un soutien émotionnel, une surveillance étroite et des soins tenant compte des traumatismes sont essentiels, les traitements empiriques étant utilisés avec prudence en raison du manque de preuves.</div></div><div><h3>Résultats</h3><div>taux de fausses couches, taux de naissances vivantes</div></div><div><h3>Avantages, inconvénients et coûts</h3><div>amélioration des taux de naissances vivantes et apport de réponses étiologiques par les professionnels de santé aux patientes concernées. Les patientes devront sacrifier du temps et subir l'inconfort des examens, avec une forte probabilité de résultats négatifs. Les coûts financiers des examens sont couverts par les régimes d'assurance maladie, mais certains traitements ne sont pas pris en charge et sont coûteux. Les examens fondés doivent être effectués conformément aux recommandations fondées sur des données probantes et être accessibles à toutes les femmes.</div></div><div><h3>Preuves</h3><div>des articles en anglais ont été recherchés entre le 1er janvier 2008 et le 30 juin 2025 dans PubMed, Cochrane Library, CINAHL, MEDLINE, Embase et Scopus à l'aide des termes de recherche généraux : abortion, abortion, recurrent abortion, recurrent miscarriage, recurrent early pregnancy loss, recurrent pregnancy loss, idiopathic pregnancy loss, idiopathic recurrent miscarriage.</div></div><div><h3>Méthodes de validation</h3><div>Les auteurs ont évalué la qualité des preuves et la force des recommandations à l'aide de l'approche GRADE (Grading of Recommendations Assessment, Development and Evaluation). Voir l'annexe A en ligne (<span><span>tableaux A1</span></span> pour les définitions et <span><span>A2</span></span> pour les interprétations des recomma
目的:本指南的目的是为卫生保健专业人员提供评估和管理重复流产患者的最新证据。* CIBLE人群:反复流产的患者,定义为两次或两次以上流产。选项:承担风险基金策略包括生活方式的改变(消耗减少咖啡因、防治肥胖、吸烟和饮酒)、甲状腺功能失调、糖尿病筛查和antiphospholipides综合症,以及处理等子宫异常子宫分割(septé)或粘连(synéchies intrautérines)。抗生素可能对慢性子宫内膜炎有益。胚胎产品的基因分析和亲本核型可以识别染色体问题。获得性血栓形成的治疗可能是有益的。黄体酮治疗可能是有用的,特别是如果开始于黄体酮期。获得早期妊娠评估诊所、情感支持、密切监测和创伤敏感护理至关重要,但由于缺乏证据,应谨慎使用实证治疗。结果:流产率、活产优势、不一致和成本:提高活产率和卫生专业人员对相关患者的病因反应。患者将不得不牺牲时间,忍受不舒服的检查,结果很可能是阴性的。检查的经济费用由健康保险计划支付,但有些治疗不包括在内,而且很昂贵。循证检查必须按照循证建议进行,并对所有妇女开放。*英文文章的证据:被通缉的2025;2008年1月1日至6月30日,在PubMed、Cochrane Library CINAHL MEDLINE、基座和Scopus借助搜索笼统:recurrent流产、堕胎、流产、recurrent miscarriage早期怀孕,recurrent loss, recurrent怀孕loss, idiopathic怀孕loss, idiopathic recurrent miscarriage。*验证方法:作者使用GRADE(建议评估、发展和评估)方法评估了证据的质量和建议的强度。在线见附录A(表A1为定义,表A2为强建议和条件[弱]的解释)。*公共视图:所有照顾重复流产患者的卫生专业人员。*社会网络摘要:重复尿布(CRF)被定义为两个或两个以上的尿布,包括不连续的和生化的尿布。其原因从染色体和解剖因素到内分泌、免疫、感染和生活方式因素,尽管大多数仍未得到解释。个性化的评估和护理至关重要。虽然有关治疗的证据各不相同,但至关重要的是在全国范围内提供对创伤敏感的护理、共同决策和平等获得检查的机会。
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引用次数: 0
Assessing the Availability and Components of Perinatal Mental Health Support Programs 评估围产期心理健康支持计划的可用性和组成部分
IF 2.2 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.jogc.2025.103163
Rebeca C. Urizar BA , Light Uchechukwu BA , Kyla F. Wiens BA , Kaeley M. Simpson MA , Bhavya Arora BA , Tia Alsaidi BA , Patricia Furer PhD , Gillian M. Alcolado PhD , Leslie Roos PhD , Kristin A. Reynolds PhD

Objectives

Despite the increasing prevalence of anxiety in the perinatal period, limited access to providers and mental health services continues to prevent affected persons from receiving necessary support. Peer support programs may provide timely, accessible support by connecting persons with others who share lived experiences. This study aimed to identify and examine perinatal peer support programs available in Canada, with particular focus on those addressing perinatal anxiety.

Methods

We conducted an online environmental scan to identify and examine existing peer support programs available in Canada for persons experiencing perinatal anxiety. Websites were screened according to the inclusion and exclusion criteria, and eligible programs were analyzed for core components such as cost, delivery format, duration, targeted outcomes, and evidence of evaluation.

Results

The scan identified 180 websites, of which 8 met the inclusion criteria. Overall, the scan revealed a lack of readily available peer support programs specifically for perinatal anxiety. Program characteristics varied: several were delivered virtually, most were free or offered low-cost options, and few specified durations. Only 1 program reported undergoing scientific evaluation, and none included participant testimonials.

Conclusions

Findings highlight the limited availability of perinatal peer support programs in Canada, particularly those targeting perinatal anxiety. Expanding accessible, evidence-based peer support tailored to this population offers a meaningful way to strengthen perinatal mental health services while emphasizing the need for continued program development and broader availability.
目标:尽管围产期焦虑的发生率越来越高,但获得提供者和心理健康服务的机会有限,继续阻碍受影响者获得必要的支持。同伴支持计划可以通过将人们与分享生活经历的人联系起来,提供及时、容易获得的支持。本研究旨在确定和检查加拿大围产期同伴支持项目,特别关注那些解决围产期焦虑的项目。方法我们进行了一项在线环境扫描,以确定和检查加拿大现有的同伴支持计划,该计划可用于经历围产期焦虑的人。根据纳入和排除标准对网站进行筛选,并分析符合条件的项目的核心组成部分,如成本、交付形式、持续时间、目标结果和评估证据。结果共扫描出180个网站,其中8个符合纳入标准。总的来说,扫描显示缺乏现成的同伴支持计划,专门针对围产期焦虑。项目的特点各不相同:有几个是虚拟交付的,大多数是免费的或提供低成本的选择,很少有指定的持续时间。只有1个项目报告进行了科学评估,没有一个项目包括参与者的证词。结论:研究结果强调了加拿大围产期同伴支持项目的有限可用性,特别是那些针对围产期焦虑的项目。扩大为这一人群量身定制的可获得的循证同伴支持为加强围产期心理健康服务提供了一种有意义的方式,同时强调继续制定方案和扩大可获得性的必要性。
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引用次数: 0
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Journal of obstetrics and gynaecology Canada
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