Journal of obstetrics and gynaecology Canada最新文献

英文中文

The Prevalence and Predictors of Reported Prenatal Anxiety Among Primigravid Individuals in Nova Scotia 新斯科舍省初潮患者产前焦虑的患病率及预测因素

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.jogc.2025.103162

Jessica Ramia BSc , Helena Piccinini-Vallis MD, PhD, CCFP

Objectives

Prenatal anxiety affects 10%–20% of pregnant Canadians and is linked to adverse maternal and neonatal outcomes. This study aimed to determine the prevalence of reported prenatal anxiety among primigravid persons with singleton pregnancies in Nova Scotia from 2004 to 2023 and explore potential predictors of reported prenatal anxiety, including birth year group, age, partner status, education level, pre-pregnancy BMI, smoking, and cannabis use.

Methods

A retrospective cohort study was conducted using the Nova Scotia Atlee Prenatal Database. The study sample consisted of 53 852 primigravid persons with singleton pregnancies.

Results

The overall prevalence of reported prenatal anxiety was 8.9%, rising significantly over time (χ² = 3513.5(3), P < 0.001) from 1.2% in the 2004-2008 period to 21.8% in the 2019–2023 period. The bivariate analyses showed significant associations between reported anxiety and all variables. In the adjusted logistic regression, the absence of a partner, lower education level, BMI ≥30.0 kg/m², smoking, and cannabis use were all independent predictors of reported prenatal anxiety, collectively explaining 17.5% of variance.

Conclusions

Reported prenatal anxiety among primigravid persons in Nova Scotia increased markedly over 2 decades and is associated with multiple sociodemographic factors. These findings highlight the importance of targeted screening and interventions to support pregnant persons at risk of prenatal anxiety.

目的产前焦虑影响了10%-20%的加拿大孕妇，并与孕产妇和新生儿的不良结局有关。本研究旨在确定2004年至2023年新斯科舍省单胎妊娠初孕者中报告的产前焦虑的患病率，并探讨报告产前焦虑的潜在预测因素，包括出生年份、年龄、伴侣状况、教育水平、孕前BMI、吸烟和大麻使用。方法采用新斯科舍省阿特利产前数据库进行回顾性队列研究。研究样本包括53 852名单胎妊娠的原孕妇女。结果报告的产前焦虑总体患病率为8.9%，随着时间的推移显著上升（χ2 = 3513.5(3), P < 0.001），从2004-2008年的1.2%上升到2019-2023年的21.8%。双变量分析显示，报告的焦虑与所有变量之间存在显著关联。在调整后的logistic回归中，缺少伴侣、低教育水平、BMI≥30.0 kg/m2、吸烟和大麻使用都是报告的产前焦虑的独立预测因素，共同解释了17.5%的方差。结论新斯科舍省初产妇的产前焦虑在过去20年中显著增加，并与多种社会人口因素有关。这些发现强调了有针对性的筛查和干预措施对支持有产前焦虑风险的孕妇的重要性。

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引用次数: 0

Septic Pelvic Thrombophlebitis 脓毒性盆腔血栓性静脉炎。

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI: 10.1016/j.jogc.2025.103158

Andrew Walkty MD , John Embil MD

引用次数: 0

Preeclampsia as a Risk Factor for Postpartum Hemorrhage: A Systematic Review and Meta-Analysis 子痫前期是产后出血的危险因素：一项系统回顾和荟萃分析。

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI: 10.1016/j.jogc.2025.103157

Natalia Valeri Gallardo Cerna MD , Nayely Marisol Jara Huapaya MD , Wilfor Aguirre Quispe MSc, MD

Objectives

Postpartum hemorrhage (PPH) remains a leading cause of maternal mortality globally. Although endothelial dysfunction and vascular alterations in preeclampsia may increase PPH risk, this association lacks robust synthesis. We conducted a systematic review and meta-analysis to quantify the impact of preeclampsia on PPH.

Methods

Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we analyzed observational studies (case-control/cohort) assessing PPH as the primary outcome. Subgroup analyses examined delivery mode and geographic region. Risk of bias was evaluated using the Newcastle-Ottawa Scale (International Prospective Register of Systematic Reviews - PROSPERO: CRD42023441579).

Results

Twelve studies (7 case-control, 5 retrospective cohorts) comprising 2 102 987 pregnancies (61 139 preeclampsia cases) were included. Preeclampsia significantly increased PPH risk (OR 1.95; 95% CI 1.70–2.23). Geographic subgroup analyses revealed highest risk in Europe (OR 2.18; 95% CI 1.67–2.14), followed by America (OR 1.95; 95% CI 1.50–2.55) and Asia (OR 1.67; 95% CI 1.28–2.18). High heterogeneity (I² = 67.5%) reflected methodologic variations. Evidence certainty was moderate (Grading of Recommendations Assessment, Development, and Evaluation); some studies indicated bias from unadjusted confounders.

Conclusions

Preeclampsia is associated with a near-doubling of PPH risk (moderate-certainty evidence). Clinical protocols should consider preeclampsia as a significant risk factor for PPH, warranting increased vigilance during delivery and the postpartum period.

目的：产后出血（PPH）仍然是全球孕产妇死亡的主要原因。虽然子痫前期的内皮功能障碍和血管改变可能增加PPH风险，但这种关联缺乏强有力的综合。我们进行了系统回顾和荟萃分析，以量化子痫前期对PPH的影响。方法：遵循PRISMA指南，我们分析观察性研究（病例对照/队列），评估PPH为主要结局。分组分析考察了交付方式和地理区域。偏倚风险采用纽卡斯尔-渥太华量表进行评估。(普洛斯彼罗:CRD42023441579)。结果：纳入12项研究（7个病例对照，5个回顾性队列），包括2102 987例妊娠（61 139例先兆子痫）。子痫前期显著增加PPH风险（OR 1.95; 95% CI 1.70-2.23）。地理亚组分析显示欧洲的风险最高（OR 2.18; 95% CI 1.67-2.14），其次是美洲（OR 1.95; 95% CI 1.50-2.55）和亚洲（OR 1.67; 95% CI 1.28-2.18）。高异质性（I2 = 67.5%）反映了方法的差异。证据确定性为中等（GRADE）；一些研究显示了未调整混杂因素的偏倚。结论：子痫前期与PPH风险增加近一倍相关（中等确定性证据）。临床方案应考虑先兆子痫作为PPH的一个重要危险因素，保证在分娩和产后期间提高警惕。

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引用次数: 0

Prolonged Exposure to Childhood Adversity and Birth Outcomes in a Bi-Generational Longitudinal Cohort Study 在一项两代纵向队列研究中，长期暴露于童年逆境和出生结果。

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-12-01 Epub Date: 2025-09-22 DOI: 10.1016/j.jogc.2025.103123

Mary-Gray Southern MD , Cara Girardi MD , Dmitry Tumin PhD , James L. Whiteside MD, MA, MHA

Objectives

A higher number of exposures to different adverse childhood experiences (ACEs) has been associated with worse birth outcomes; however, the duration of ACE exposure could also negatively impact pregnancy outcomes. We sought to use a bi-generational longitudinal cohort survey to test if duration of exposure to specific types of childhood adversity exhibited a graded association with adverse birth outcomes.

Methods

The Bureau of Labor Statistics’ National Longitudinal Surveys of Youth 1979 cohort was used to create bi-generational cohorts capturing the number and duration of ACE events (reported by the oldest cohort and experienced by the middle cohort) and linking these with birth outcomes (low birth weight, preterm birth, route of delivery, and infant length of stay) documented in the youngest cohort. ACEs examined were maternal incarceration, divorce/separation, maternal binge drinking, and poverty.

Results

Demographic, birth outcome, and ACE exposures were determined from 1693 cases. Neither the count of ACEs nor the duration of exposure to ACEs was a statistically significant predictor of examined birth outcomes, except for greater ACE numbers and prolonged infant length of stay.

Conclusions

No association was identified between worsened birth outcomes and cumulative number or duration of ACE exposures, contradicting prior studies. This discrepancy may be explained by the mediating role of stressors encountered in adulthood, interactions between ACE exposure and adult-onset conditions, missing data on paternal ACE exposure, or differences in recall and reporting bias when collecting interview data from participants versus directly from the grandparent generation.

目的：不同童年不良经历（ace）的暴露次数越多，出生结局越差；然而，ACE暴露的持续时间也可能对妊娠结局产生负面影响。我们试图使用一项两代纵向队列调查来测试暴露于特定类型的童年逆境的持续时间是否与不良出生结局表现出分级关联。方法：采用美国劳工统计局1979年全国青年纵向调查（National Longitudinal Surveys of Youth）的队列数据创建两代人队列，收集年龄最大的队列报告的ACE事件的数量和持续时间，中间队列经历的ACE事件，并将这些事件与年龄最小队列记录的出生结果（低出生体重、早产、分娩方式和婴儿住院时间）联系起来。调查的ace包括母亲入狱、离婚/分居、母亲酗酒和贫困。结果：从1693例病例中确定了人口统计学、出生结局和ACE暴露。ACE的数量和暴露于ACE的持续时间都不是所检查的出生结果的统计显著预测因子，除了ACE的数量和延长的婴儿停留时间（LOS）。结论：与先前的研究相反，没有发现出生结果恶化与ACE暴露的累积次数或持续时间之间存在关联。这种差异可能是由于成年期遇到的压力源的中介作用，ACE暴露与成年发病条件之间的相互作用，父亲ACE暴露的数据缺失，或者从参与者那里收集访谈数据与直接从祖父母辈收集访谈数据时回忆和报告偏差的差异。

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引用次数: 0

Uterine Rupture with Fetal Leg Extrusion 子宫破裂伴胎腿挤压

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.jogc.2025.103164

Hongwei Li MD , Zi-yun Liao MD , Zhenbo OuYang MD

引用次数: 0

HPV prevention is better than cure 预防胜于治疗

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.jogc.2025.103160

Wiebren Tjalma MD, PhD (full Professor)

引用次数: 0

Endometritis Following Pregnancy: A Comparative Cohort Study of Cases With and Without RPOC 妊娠后子宫内膜炎：有和没有RPOC病例的比较队列研究。

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI: 10.1016/j.jogc.2025.103155

Nati Bor MD , Itay Hazan MD , Ronny Ram Biton MD , Ido Givon MD , Ran Matot MD , Lior Friedrich MD , Gil Zeevi MD , Haim Krissi MD

Objectives

This study aimed to compare the clinical course, management, and outcomes of women diagnosed with endometritis following delivery or abortion, with and without retained products of conception (RPOC).

Methods

A retrospective cohort study was conducted at a single tertiary medical centre between 2012 and 2023. Women admitted with a diagnosis of endometritis or pelvic inflammatory disease following delivery or abortion were identified and divided into 2 groups based on the presence or absence of RPOC. Clinical presentation, laboratory results, antibiotic treatment, need for surgical intervention, and severe complications were compared between groups.

Results

A total of 341 women were included, of whom 32 (9.4%) had RPOC. Baseline laboratory values did not differ significantly between groups. Most patients responded well to empiric antibiotic therapy, and modification of the antibiotic regimen was rare in both groups (0% in RPOC vs. 6.5% in non-RPOC, P = 0.2). Surgical interventions were significantly more frequent in the RPOC group (49% vs. 5.2%, P < 0.001), while severe complications such as intensive care unit admission, sepsis, and hysterectomy were rare in both groups.

Conclusions

Endometritis with RPOC does not necessarily follow a more severe course than endometritis alone. Most patients, regardless of RPOC status, improved with antibiotics alone. These findings support an individualized approach, wherein clinical stability may allow for conservative management of suspected infected RPOC.

目的：比较分娩或流产后诊断为子宫内膜炎的妇女的临床过程、处理和结局，有和没有保留妊娠产物（RPOC）。研究设计：2012年至2023年在单一三级医疗中心进行回顾性队列研究。分娩或流产后被诊断为子宫内膜炎或盆腔炎的妇女被确定并根据是否存在RPOC分为两组。比较两组患者的临床表现、实验室结果、抗生素治疗、手术干预需求和严重并发症。结果：共纳入341例妇女，其中32例（9.4%）有RPOC。试验室基线值在两组间无显著差异。大多数患者对经经性抗生素治疗反应良好，两组患者很少对抗生素方案进行修改（RPOC患者为0%，非RPOC患者为6.5%,P = 0.2）。RPOC组的手术干预明显更频繁（49% vs. 5.2%, P < 0.001），而重症监护病房入院、脓毒症或子宫切除术等严重并发症在两组中都很少见。结论：子宫内膜炎合并RPOC并不一定比单独的子宫内膜炎更严重。大多数患者，无论RPOC状态如何，单独使用抗生素均可改善。这些发现支持个体化治疗方法，其中临床稳定性可能允许对疑似感染的RPOC进行保守治疗。

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引用次数: 0

Can I get an Abortion Without my Parents’ Permission? Publicly Available Information About Age and Parental Consent for Abortion in Canada 我可以在没有父母允许的情况下堕胎吗？加拿大关于年龄和父母同意堕胎的公开信息。

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-11-01 Epub Date: 2025-09-05 DOI: 10.1016/j.jogc.2025.103099

Eleanor McGrath BComm, MSW

Objectives

This study aimed to investigate the availability and clarity of online abortion access information in Canada and identify, through the lens of a minor, if websites provide a clear answer to: “Can I get an abortion without my parents’ permission?”

Methods

Using ChoiceConnect, 139 abortion providers and 17 health resource websites were identified for analysis. Provider information was searched to discover an associated website. Identified websites were searched using Boolean operators for plain-language keywords on abortion access for minors (‘abortion,’ ‘consent,’ ‘permission,’ ‘parent,’ or ‘age,’) followed by manual searches. Results were classified as: (1) no abortion information; (2) no consent information; or (3) included consent information. Those that included consent information were further categorized thematically as either (1) statements that parental consent is not required; (2) statement regarding capacity to consent; or (3) stating an age of consent. These categories overlapped in some cases.

Results

Of the 139 providers, 72 had identifiable websites. Of those, 14 (19%) did not mention abortion and 28 (39%) provided information about parental or age of consent. Among those 28, 20 (74%) stated no parental consent was required, 10 (37%) mentioned capacity to consent, and 6 (22%) indicated an age to consent. Overall, 75% of providers and resources did not have a website, mention abortion, or provide consent information.

Conclusions

There is a lack of clear information online about minors’ abortion care access without parental consent. Absence of information presents a substantial barrier to abortion care access for minors.

目的：调查加拿大在线堕胎信息的可用性和清晰度，并通过未成年人的视角确定网站是否为“我可以在未经父母允许的情况下堕胎吗？”提供了明确的答案。方法：使用ChoiceConnect对139家人工流产服务提供者和17家健康资源网站进行分析。搜索提供商信息以发现关联网站。对确定的网站使用布尔运算符搜索有关未成年人堕胎途径的简单语言关键词（“堕胎”、“同意”、“许可”、“父母”或“年龄”），然后进行人工搜索。结果分为：1-无流产信息；2-无同意信息；或3-包括同意信息。那些包含同意信息的内容被进一步分类为：1-不需要父母同意的声明；2-关于同意能力的声明；或3岁-说明同意年龄。这些类别在某些情况下是重叠的。结果：在139家供应商中，72家有可识别的网站。其中，14个（19%）没有提到堕胎，28个（39%）提供了父母或同意年龄的信息。在这28人中，20人（74%）表示不需要父母的同意，10人（37%）提到了同意的能力，6人（22%）表示同意的年龄。总的来说，75%的提供者和资源没有网站，没有提到堕胎，也没有提供同意信息。结论：网上缺乏关于未成年人未经父母同意获得人工流产护理的明确信息。缺乏信息是未成年人获得堕胎护理的一个重大障碍。

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引用次数: 0

Serum Biglycan and Decorin as Biomarkers for Preterm Birth: A Prospective Cohort Study 血清Biglycan和Decorin作为早产的生物标志物：一项前瞻性队列研究。

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-11-01 Epub Date: 2025-08-26 DOI: 10.1016/j.jogc.2025.103086

Sundas Akram Mphil, Kaleem Maqsood PhD, Javeria Malik PhD, Nabila Roohi PhD

Objectives

Preterm birth (PTB) affects 10% of pregnancies worldwide, causing significant neonatal morbidity and mortality. Biglycan and decorin, essential proteoglycans in fetal membranes, are linked to spontaneous PTB pathophysiology. This study investigates their potential as biomarkers for spontaneous PTB.

Methods

This study included 500 pregnant women from various hospitals. Blood samples were collected, and participants were followed up until delivery. Pregnant women were categorized into groups based on gestational age at birth: moderate PTB, very PTB (vPTB), and term birth (control group). Serum levels of biglycan and decorin were measured using enzyme-linked immunosorbent assay kits. Statistical analysis included analysis of variance, logistic regression, and receiver operating characteristic curve evaluation using SPSS.

Results

Serum levels of biglycan were higher in the vPTB group in the second (82.49 ± 2.86 pg/mL, P = 0.0012) and third trimesters (81.17 ± 2.01 pg/mL, P = 0.0097). In both trimesters, decorin levels were lower in the vPTB group (second: 36.32 ± 0.90 ng/mL, P = 0.0013; third: 34.25 ± 1.86 ng/mL, P = 0.0023). Receiver operating characteristic curve analysis showed fair discriminatory power for decorin in the third trimester (area under the curve = 0.70, P = 0.0021). Multinomial logistic regression further confirmed that both biomarkers (biglycan: OR 1.034, P = 0.001; decorin: OR 0.914, P = 0.001) were significant predictors of PTB.

Conclusions

Reduced amount of decorin and increased concentration of biglycan during pregnancy were associated with enhanced risk of spontaneous PTB. These results support the potential of early gestation serum glycoprotein complex as a predictive model for spontaneous PTB.

导读：早产（PTB）影响全球10%的妊娠，造成显著的新生儿发病率和死亡率。Biglycan和decorin是胎膜中必需的蛋白聚糖，与自发性肺结核的病理生理有关。本研究探讨了它们作为自发性肺结核生物标志物的潜力。方法：本研究包括500名来自不同医院的孕妇。研究人员采集了参与者的血液样本，并对他们进行了随访，直到分娩。孕妇根据出生时的胎龄分为三组：中度早产（mPTB）、重度早产（vPTB）和足月分娩（对照组）。采用酶联免疫吸附试验（ELISA）检测血清多糖和decorin水平。统计分析采用方差分析、logistic回归及SPSS进行ROC曲线评价。结果：vPTB组在妊娠中期（82.49±2.86 pg/mL, P = 0.0012）和妊娠晚期（81.17±2.01 pg/mL, P = 0.0097）血清biglycan水平均较高。vPTB组的Decorin水平在两个妊娠期均较低（第二组：36.32±0.90 ng/mL, P = 0.0013；第三组：34.25±1.86 ng/mL, P = 0.0023）。ROC曲线分析显示，妊娠晚期decorin的区分力较好（AUC = 0.70, P = 0.0021）。多项logistic回归进一步证实了这两种生物标志物（biglycan: OR;1.034, P = 0.001）和decorin: OR； 0.914, P = 0.001)是早产的显著预测因子。结论：妊娠期decorin量的减少和biglycan浓度的升高与自发性早产的风险增加有关。这些结果支持早期妊娠血清糖蛋白复合物作为自发性早产的预测模型的潜力。

{"title":"Serum Biglycan and Decorin as Biomarkers for Preterm Birth: A Prospective Cohort Study","authors":"Sundas Akram Mphil, Kaleem Maqsood PhD, Javeria Malik PhD, Nabila Roohi PhD","doi":"10.1016/j.jogc.2025.103086","DOIUrl":"10.1016/j.jogc.2025.103086","url":null,"abstract":"<div><h3>Objectives</h3><div>Preterm birth (PTB) affects 10% of pregnancies worldwide, causing significant neonatal morbidity and mortality. Biglycan and decorin, essential proteoglycans in fetal membranes, are linked to spontaneous PTB pathophysiology. This study investigates their potential as biomarkers for spontaneous PTB.</div></div><div><h3>Methods</h3><div>This study included 500 pregnant women from various hospitals. Blood samples were collected, and participants were followed up until delivery. Pregnant women were categorized into groups based on gestational age at birth: moderate PTB, very PTB (vPTB), and term birth (control group). Serum levels of biglycan and decorin were measured using enzyme-linked immunosorbent assay kits. Statistical analysis included analysis of variance, logistic regression, and receiver operating characteristic curve evaluation using SPSS.</div></div><div><h3>Results</h3><div>Serum levels of biglycan were higher in the vPTB group in the second (82.49 ± 2.86 pg/mL, <em>P</em> = 0.0012) and third trimesters (81.17 ± 2.01 pg/mL, <em>P</em> = 0.0097). In both trimesters, decorin levels were lower in the vPTB group (second: 36.32 ± 0.90 ng/mL, <em>P</em> = 0.0013; third: 34.25 ± 1.86 ng/mL, <em>P</em> = 0.0023). Receiver operating characteristic curve analysis showed fair discriminatory power for decorin in the third trimester (area under the curve = 0.70, <em>P</em> = 0.0021). Multinomial logistic regression further confirmed that both biomarkers (biglycan: OR 1.034, <em>P</em> = 0.001; decorin: OR 0.914, <em>P</em> = 0.001) were significant predictors of PTB.</div></div><div><h3>Conclusions</h3><div>Reduced amount of decorin and increased concentration of biglycan during pregnancy were associated with enhanced risk of spontaneous PTB. These results support the potential of early gestation serum glycoprotein complex as a predictive model for spontaneous PTB.</div></div>","PeriodicalId":16688,"journal":{"name":"Journal of obstetrics and gynaecology Canada","volume":"47 11","pages":"Article 103086"},"PeriodicalIF":2.2,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrial Carcinoma Molecular Classification and Barriers to Implementation, Possible Solutions, and the Implications for Ongoing Clinical Trials 子宫内膜癌分子分类和实施的障碍，可能的解决方案和对正在进行的临床试验的影响。

IF 2.2 Q2 OBSTETRICS & GYNECOLOGY

Journal of obstetrics and gynaecology Canada

Pub Date : 2025-11-01 Epub Date: 2025-09-18 DOI: 10.1016/j.jogc.2025.103124

Anjelica Hodgson MD , Kathy Han MD, MSc , Stephen Welch MD , Wendy R. Parulekar MD , Jessica N. McAlpine MD , Mary Kinloch MD

Molecular classification of endometrial carcinoma provides important prognostic and predictive information and ongoing clinical trials are investigating different treatment paradigms and therapy de-escalation. Despite its benefits, there is variability in the application of molecular classification worldwide, including in Canada. A digital survey was distributed to gynaecologic pathologists in 13 Canadian academic pathology departments, and areas of homogeneity and variability in practice for endometrial carcinoma molecular classification were identified. Perceived barriers to universal application included resource restrictions and ambiguity of management implications. Focused research, knowledge translation, and guideline development will aid in more consistent implementation/application.

子宫内膜癌的分子分类提供了重要的预后和预测信息，正在进行的临床试验正在研究不同的治疗模式和治疗降级。尽管它的好处，有在世界各地的应用分子分类的变化，包括在加拿大。一项数字调查被分发给13个加拿大学术病理部门的妇科病理学家，并确定了子宫内膜癌分子分类在实践中的同质性和可变性。普遍应用的障碍包括资源限制和管理影响的模糊性。重点研究、知识转化和指南制定将有助于更一致的实施/应用。

引用次数: 0

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