Objective
As survival in cystic fibrosis (CF) continue to improve, more women with CF are considering their reproductive options. However, there are limited data on pregnancy and neonatal outcomes in this population. This study aimed to describe maternal and neonatal outcomes in women with CF and the general Canadian maternal population (general population).
Methods
Data on maternal and neonatal clinical outcomes and health care utilization for in-hospital live births were retrieved from the Canadian Institute for Health Information’s Discharge Abstract Database. Mothers with CF were identified using the International Classification of Diseases, 10th Revision, Canadian Modification code for CF. The observation period spanned from fiscal year (FY) 2006–2007 to FY 2020–2021 for mothers with CF, and FY 2019–2020 for the general population.
Results
During the 15-year observation period, 124 mothers with CF had 146 deliveries, resulting in 154 newborns. Relative to the general population, mothers with CF were younger (median age 28 vs. 31 years) and had higher rates of comorbidities, induction of labour, epidural use, assisted delivery, and use of assisted reproductive technologies, but fewer cesarean deliveries. Nearly 85% of mothers with CF delivered in a hospital that had a CF clinic; 6.8% of mothers with CF were admitted to the intensive care unit. Neonates born to mothers with CF had high rates of multiple births, preterm delivery, and jaundice, with 26.6% requiring admission to the neonatal intensive care unit.
Conclusions
While no inferential analyses were conducted, mothers with CF and their newborns may experience worse post-delivery outcomes and may require more health care resources than the general population.
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