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2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom)最新文献

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Generic features for fundus image quality evaluation 眼底图像质量评价的一般特征
Zhen-Jie Yao, Zhi-Peng Zhang, Li-Qun Xu, Qingxia Fan, Ling Xu
Fundus image is important for the medical screening and diagnosis of variety ophthalmopathy. The effectiveness of such a process, however, depends very much on the quality of the fundus image captured. This paper aims to asses in real-time the quality of a fundus image by first extracting a multitude of generic features, including statistical characteristics, entropy, texture, symmetry, frequency components and blur metric, which is then followed by a support vector machine (SVM) trained to filter out the poor quality image for clinic usage. The method was tested on a dataset of 3224 images collected from an eye hospital's practical screening project in rural areas in Northeastern Region of China. With the detection rate achieved being 0.9308, the corresponding false alarm rate is 0.1127, and the overall accuracy is 0.9138. The area under an ROC curve is as high as 0.9619. It is shown that the fundus images of poor quality can be automatically detected on the spot to ensure a clinically meaningful ophthalmopathy screening and diagnosis by a human expert or even an artificial intelligence software.
眼底图像对各种眼病的医学筛查和诊断具有重要意义。然而,这种方法的有效性在很大程度上取决于眼底图像的质量。本文旨在实时评估眼底图像的质量,首先提取大量的通用特征,包括统计特征、熵、纹理、对称性、频率成分和模糊度量,然后使用训练好的支持向量机(SVM)过滤掉质量较差的图像以供临床使用。该方法在中国东北地区农村眼科医院实际筛查项目中收集的3224张图像数据集上进行了测试。实现的检出率为0.9308,对应的虚警率为0.1127,总体准确率为0.9138。ROC曲线下面积高达0.9619。结果表明,对于质量较差的眼底图像,可以在现场自动检测出来,从而保证由人类专家甚至人工智能软件进行有临床意义的眼病筛查和诊断。
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引用次数: 18
Patterns for conflict identification in clinical trial eligibility criteria 临床试验资格标准中冲突识别的模式
Bonnie K. MacKellar, Christina Schweikert
Patients with serious diseases, such as cancer, often must consider and choose between multiple clinical trials. Patients are often concerned that participation in one clinical trial may preclude their participation in another trial. We are developing a system to help patients in this decision making process, focusing on pediatric cancer where clinical trial participation is very high. In this paper, we present a detailed description of the approach used to process and analyze the eligibility constraints, using a pattern-based approach from the literature. We show how the semantic categorizations produced by these patterns can be used to determine which eligibility constraints can produce conflicts, as well as to guide an analysis algorithm. This work contributes to research on using eligibility criteria and other clinical trial information to better support patient decision making and to improve accrual of patients into clinical trials.
患有严重疾病(如癌症)的患者经常必须考虑并在多个临床试验之间做出选择。患者常常担心参加一项临床试验可能会妨碍他们参加另一项试验。我们正在开发一个系统,以帮助患者在这个决策过程中,专注于儿科癌症,临床试验参与率非常高。在本文中,我们使用文献中的基于模式的方法,详细描述了用于处理和分析资格约束的方法。我们将展示如何使用这些模式产生的语义分类来确定哪些资格约束会产生冲突,以及如何指导分析算法。这项工作有助于研究使用资格标准和其他临床试验信息,以更好地支持患者决策,并提高患者进入临床试验的累积。
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引用次数: 3
Exploiting riemannian manifolds for daily activity classification in video towards health care 利用黎曼流形对医疗保健视频中的日常活动分类
Y. Yun, I. Gu
This paper addresses the problem of classifying activities of daily living in video. The proposed method uses a tree structure of two layers, where in each node of the tree there resides a Riemannian manifold that corresponds to different part-based covariance features. In the first layer, activities are classified according to the dynamics of upper body parts. In the second layer, activities are further classified according to the appearance of local image patches at hands in key frames, where the interacting objects are likely to be attached. The novelties of this paper include: (i) characterizing the motion of upper body parts by a covariance matrix of distances between each pair of key points and the orientations of lines that connect them; (ii) describing human-object interaction by the appearance of local regions around hands in key frames that are selected based on the proximity of hands to other key points; (iii) formulating a pairwise geodesics-based kernel for activity classification on Riemannian manifolds under the log-Euclidean metric. Experiments were conducted on a video dataset containing a total number of 426 video events (activities) from 4 classes. The proposed method is shown to be effective by achieving high classification accuracy (93.79% on average) and small false alarms (1.99% on average) overall, as well as for each individual class.
本文研究了视频中日常生活活动的分类问题。该方法采用两层树形结构,在树的每个节点上驻留一个黎曼流形,对应于不同的基于部分的协方差特征。在第一层,活动是根据上半身的动态分类的。在第二层,根据关键帧中手头的局部图像补丁的外观进一步分类活动,其中交互对象可能被附加。本文的新颖之处包括:(i)通过每对关键点之间的距离和连接它们的线的方向的协方差矩阵来表征上半身部分的运动;(ii)通过关键帧中手周围局部区域的出现来描述人与物体的相互作用,这些区域是根据手与其他关键点的接近程度选择的;(iii)在对数欧几里德度量下,为黎曼流形上的活动分类提出了基于成对测地线的核。实验在包含4个类的426个视频事件(活动)的视频数据集上进行。结果表明,该方法具有较高的分类准确率(平均为93.79%)和较小的误报率(平均为1.99%)。
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引用次数: 5
ParkNosis: Diagnosing Parkinson's disease using mobile phones ParkNosis:用手机诊断帕金森病
Abdulwahab Sahyoun, Karim Chehab, O. Al-Madani, F. Aloul, A. Sagahyroon
This paper aims to provide a Parkinson's Disease (PD) symptoms assessment tool using an Android smartphone application that allows PD patients to assess their symptoms using both quantitative and qualitative tests. Simple touch screen and motion tests focus on objectively measuring PD symptoms, whereas a questionnaire targets the subjective ones. The concatenation of the collected results will allow the application to accurately target several PD symptoms without visual or traditional assessment. Physicians, hospitals, and clinics will then be able to receive this data over the network for further assessment, analysis, and research. This enables the self-monitoring of patients, as well as remote monitoring from physicians in clinics and hospitals. In addition to this, this application aims to expand PD research and provide improvements to the current treatment process. Ultimately, the aim is to enable thousands of people, anywhere and at any time, to easily diagnose and assess the PD before visiting a specialist.
本文旨在利用Android智能手机应用程序提供帕金森病(PD)症状评估工具,允许PD患者通过定量和定性测试来评估其症状。简单的触摸屏和运动测试侧重于客观测量PD症状,而问卷调查则针对主观症状。收集结果的串联将允许应用程序准确地针对几种PD症状,而无需视觉或传统的评估。然后,医生、医院和诊所将能够通过网络接收这些数据,以进行进一步的评估、分析和研究。这使得患者可以自我监测,也可以由诊所和医院的医生远程监测。除此之外,该应用程序旨在扩大PD研究并对当前的治疗过程提供改进。最终的目标是使成千上万的人,无论何时何地,在拜访专家之前,都能轻松地诊断和评估PD。
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引用次数: 18
Wireless solution to prevent decubitus ulcers: Preventive weight shifting guide, monitor, and tracker app for wheel chair users with spinal cord injuries (phase II) 预防褥疮的无线解决方案:针对脊髓损伤的轮椅使用者的预防性体重转移指南、监视器和跟踪器应用程序(第二阶段)
Arshia A. Khan, M. Reuter, N. Phung, Syed S. Hafeez
Pressure ulcers pose a huge financial burden on the economy. Pressure ulcers cost between $9.1 to 11.6 billion a year in the United States. Each individual pressure can cost from $20,900 to $151,700 per pressure ulcer. Wheelchair users with spinal cord injury have a higher risk of developing pressure ulcers due to limited mobility and the countless hours they spend in the wheelchair, exerting pressure on the points of interface between the bony structure and the wheelchair cushion. The areas of interface that are under prolonged pressure lack blood flow, causing the tissue to breakdown, leading to a decubitus or pressure ulcer. Approximately 28.9 % wheelchair users in communities, 27% in nursing homes, and between 5 and 30% of hospitalized patients develop pressure sores. Nearly 70% of elderly patients develop pressure ulcers, which in turn significantly increase the healthcare management and costs and can be a cause of pain, discomfort, loss of independence and mobility in not only the elderly but also the younger patients. Mobile technology can be exploited to provide a technological solution to preventing pressure ulcers. An app was designed and developed to notify, walk through the process of weight shifting and also track the movements of the patient performing weight shifting using the accelerometer. The app was tested to find that the forward lean movements can be tracked accurately using the accelerometer but the lateral movements although tracked could not verify that the weight shifting was correctly performed. In order to fix this issue the pressure map is used as an additional sensor to track and monitor the weight shifting accurately. This paper discusses the design and development of the app in two phases.
压力性溃疡给经济带来了巨大的财政负担。在美国,每年用于治疗压疮的费用在91亿到116亿美元之间。每次压力性溃疡的费用从20,900美元到151,700美元不等。脊髓损伤的轮椅使用者患压疮的风险更高,因为他们的行动能力有限,而且他们在轮椅上花费了无数的时间,对骨骼结构和轮椅垫之间的界面点施加压力。界面区域在长时间的压力下缺乏血液流动,导致组织破裂,导致褥疮或压力性溃疡。大约28.9%的社区轮椅使用者、27%的养老院轮椅使用者以及5%至30%的住院患者患有压疮。近70%的老年患者患有压疮,这反过来又大大增加了医疗保健管理和成本,并且不仅是老年人而且是年轻患者疼痛、不适、丧失独立性和行动能力的原因。移动技术可以为预防压疮提供技术解决方案。设计并开发了一款应用程序,用于通知、行走体重转移过程,并使用加速度计跟踪患者进行体重转移的动作。经过测试,该应用程序发现,向前倾斜的运动可以使用加速度计准确地跟踪,但横向运动虽然跟踪无法验证正确执行的重量转移。为了解决这个问题,压力图被用作一个额外的传感器来准确地跟踪和监测重量的变化。本文分两个阶段讨论了应用程序的设计和开发。
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引用次数: 3
Integrating multiple data sources in a cardiology imaging laboratory 在心脏病成像实验室中集成多个数据源
T. Godinho, Eduardo Almeida, Luís Bastião, C. Costa
Nowadays, medical imaging laboratories are supported by heterogeneous systems, including image repositories, acquisition devices, viewer workstations and other administrative information systems. They hold tremendous amounts of data resulting not only from imaging modalities, but also from patient diagnosis, treatment, and services management. Unfortunately, the interoperability between the different medical information systems is still a major limitation. Despite the existence of standards to support the distinct RIS and PACS applications, such as DICOM and HL7, the interoperability between them is, in most cases, limited to a few sets of information elements. As a result, the establishment of cooperative workflows or the integrated visualization of patient data is still compromised. Moreover, this scenario severely constraints the usage of these data for research and business analytics purposes, commonly referred as secondary uses of data. In this document, we propose a method for transforming echocardiography reports held by proprietary information systems into DICOM Structured Reports (SR), the gold standard for interoperability in medical imaging. As a result, reports, images, and associated metadata can be accessed and shared by all PACS applications in an integrated and structured manner. Furthermore, the large-scale federation of those elements has a tremendous interest for data analytics and secondary uses of data.
目前,医学成像实验室由异构系统支持,包括图像存储库、采集设备、查看器工作站和其他管理信息系统。它们不仅拥有来自成像模式的大量数据,还拥有来自患者诊断、治疗和服务管理的大量数据。不幸的是,不同的医疗信息系统之间的互操作性仍然是一个主要的限制。尽管存在支持不同RIS和PACS应用程序的标准,如DICOM和HL7,但在大多数情况下,它们之间的互操作性仅限于几组信息元素。因此,协作工作流程的建立或患者数据的集成可视化仍然受到损害。此外,这种情况严重限制了这些数据用于研究和业务分析目的的使用,通常称为数据的二次使用。在本文中,我们提出了一种将专有信息系统保存的超声心动图报告转换为DICOM结构化报告(SR)的方法,这是医学成像中互操作性的黄金标准。因此,所有PACS应用程序都可以以集成和结构化的方式访问和共享报告、图像和相关元数据。此外,这些元素的大规模联合对数据分析和数据的二次使用具有巨大的兴趣。
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引用次数: 2
Anatomy of log files: Implications for information accountability measures 日志文件的剖析:信息问责措施的含义
C. Wickramage, T. Sahama, C. Fidge
Due to the growing use of digital technologies and Electronic Health Record systems, new auditing mechanisms are needed to help protect stakeholders from information misuse, both deliberate and accidental. Electronic storage of health records and use of sensor networks, wearable and ubiquitous health tracking devices raise numerous privacy related threats for both healthcare providers and their patients. A purely preventive approach to information access is not appropriate in healthcare scenarios, especially during emergencies, so after-the-fact justifications are needed to manage information handling risks in such an environment. To allow such justifications we need to analyse the root causes for unusual human actions or behaviours but current system event logs are inadequate for this purpose. Hence, a better solution would be to generate audit logs sufficient for analysing information use anomalies. Here we explain the limitations of existing event logs in clinical settings when attempting to perform after-the-fact justifications as part of a clinical Information Accountability system. From this we recommend additional features that must be added to event logs to support a healthcare-based Information Accountability Framework.
由于越来越多地使用数字技术和电子健康记录系统,需要新的审计机制来帮助保护利益相关者免受蓄意和意外的信息滥用。健康记录的电子存储和传感器网络、可穿戴和无处不在的健康跟踪设备的使用,给医疗保健提供者及其患者带来了许多与隐私相关的威胁。纯预防性的信息访问方法不适用于医疗保健场景,特别是在紧急情况下,因此需要事后证明,以便在这种环境中管理信息处理风险。为了允许这样的理由,我们需要分析不寻常的人类行为或行为的根本原因,但当前的系统事件日志不足以满足此目的。因此,更好的解决方案是生成足以分析信息使用异常的审计日志。在这里,我们解释现有的事件日志在临床设置的局限性,当试图执行事后证明作为临床信息问责制的一部分。据此,我们推荐必须添加到事件日志中的其他功能,以支持基于医疗保健的信息责任框架。
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引用次数: 12
Echocardiography to cardiac CT image registration: Spatial and temporal registration of the 2D planar echocardiography images with cardiac CT volume 超声心动图与心脏CT图像的配准:二维平面超声心动图图像与心脏CT体积的时空配准
A. Khalil, Y. Liew, S. Ng, K. Lai, Y. Hum
This study proposes a registration framework to register 2D echocardiography images with cardiac CT volume. The registration realizes the fusion of CT and echocardiography with the aim to aid the diagnosis of cardiac diseases. The image registration framework consists of two major steps: temporal and spatial registration. Temporal registration utilizes the ECG data to identify frames at similar cardiac phase as the CT volume. Spatial registration is an intensity-based normalized mutual information (NMI) method applied with pattern search optimization algorithm to produce interpolated cardiac CT image that matches the echocardiography image. Our proposed registration method has been applied on the short axis "Mercedes Benz" sign view of the aortic valve. The accuracy of our fully automated registration method were 0.81 ± 0.08 and 1.30 ± 0.13 mm in terms of Dice coefficient and Hausdorff distance. This accuracy is comparable to gold standard manual registration by expert. There was no significant difference in aortic annulus diameter measurement between the automatically and manually registered CT images. Without the use of optical tracking, we have shown the applicability of this technique for effective registration of echocardiography with cardiac CT volume.
本研究提出了一种配准框架,将二维超声心动图图像与心脏CT容积进行配准。该配准实现了CT与超声心动图的融合,以辅助心脏疾病的诊断。图像配准框架包括两个主要步骤:时间配准和空间配准。时间配准利用ECG数据来识别与CT容积相似的心脏相帧。空间配准是一种基于强度的归一化互信息(NMI)方法,结合模式搜索优化算法生成与超声心动图匹配的内插心脏CT图像。我们提出的配准方法已应用于主动脉瓣短轴“奔驰”标志视图。全自动配准方法的Dice系数和Hausdorff距离精度分别为0.81±0.08 mm和1.30±0.13 mm。这种精度可与专家手工注册的黄金标准相媲美。自动配准与人工配准的CT图像在主动脉环直径测量上无显著差异。在不使用光学跟踪的情况下,我们已经证明了这种技术在心脏CT容积超声心动图有效登记方面的适用性。
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引用次数: 4
Experiment design of free pregnancy monitoring mobile personal health records quality evaluation 免费孕期监测移动个人健康档案质量评价实验设计
A. Idri, M. Bachiri, J. Alemán, J. Álvarez
In order to improve the management of the patients' health data and promote the exchange between the patients and healthcare providers, mobile personal health records (mPHRs), as mobile applications, are used to access, store and manage these data. In this paper, a design of the software quality evaluation of free mPHRs for pregnancy monitoring is introduced. Ten mobile applications (4 for iOS and 6 for Android) are selected for the evaluation. A list of tasks is set to be executed in order to answer a quality assessment questionnaire that is developed for this purpose, covering the four quality characteristics: Functional suitability, Operability, Performance efficiency and Reliability, by using the ISO/IEC 25010 quality standard. This evaluation aims to analyze the degree of meeting these quality characteristics, in addition to the compliance between the users' ratings in the apps stores and the fulfillment of the quality characteristics by the mPHRs for pregnancy monitoring. This study is intended to be developed by conducting the proposed design of the evaluation, which will be of great use for the developers of these apps for further improvements.
为了改进对患者健康数据的管理并促进患者与医疗保健提供者之间的交换,移动个人健康记录(mPHRs)作为移动应用程序被用于访问、存储和管理这些数据。本文介绍了一种用于妊娠监测的免费mphr软件质量评价的设计。10个移动应用程序(4个用于iOS, 6个用于Android)被选中进行评估。通过使用ISO/IEC 25010质量标准,为回答为此目的制定的质量评估问卷,设置了要执行的任务列表,包括四个质量特征:功能适用性、可操作性、性能效率和可靠性。本次评价的目的是分析这些质量特征的满足程度,以及用户在应用商店的评分与孕期监测孕产妇对质量特征的满足程度之间的符合性。本研究旨在通过进行评估的拟议设计来开发,这将对这些应用程序的开发人员进行进一步改进有很大的帮助。
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引用次数: 16
Architecture of a web-based DICOM viewer showing segmentations and simulations 显示分段和模拟的基于web的DICOM查看器的体系结构
Roland Ellerweg, Dominic Reuter, Phil Weir
In teleradiology doctors view the image data of a healthcare institution from a remote site. To do so they typically connect to an image repository, download the necessary data and finally view it in a locally installed DICOM viewer. Recent research activities in teleradiology [1, 2, 3, 4] focus on the implementation of ubiquitously accessible web-based DICOM viewers which simplify the access and the collaboration among radiologists. However, these solutions either have a weak performance, they run on the client side only, or they are not as feature rich as their desktop counterpart. In this contribution we present an architecture of a web based DICOM viewer which has both, good performance as well as advanced features such as the visualization of anatomical structures. On the client side only native web technologies are used. The whole architecture has been implemented and evaluated in the GoSmart environment, a planning tool for minimally invasive cancer treatment.
在远程放射学中,医生从远程站点查看医疗机构的图像数据。为此,它们通常连接到映像存储库,下载必要的数据,最后在本地安装的DICOM查看器中查看数据。远程放射学最近的研究活动[1,2,3,4]集中在实现无处不在的可访问的基于web的DICOM查看器,这简化了放射科医生之间的访问和协作。然而,这些解决方案要么性能较差,要么只能在客户端运行,要么不如桌面解决方案功能丰富。在这篇文章中,我们提出了一个基于web的DICOM查看器的架构,它具有良好的性能和先进的功能,如解剖结构的可视化。在客户端只使用本地web技术。整个架构已经在微创癌症治疗的规划工具GoSmart环境中实施和评估。
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引用次数: 4
期刊
2016 IEEE 18th International Conference on e-Health Networking, Applications and Services (Healthcom)
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