Pratyusha Ghanta, U. Bhatnagar, S. Pasumarthi, Sunil Kumar Chiliveri
{"title":"Cytotoxic Evaluation Using Murine Fibroblasts (L-929) Three Dimensional Cell Culture Technique","authors":"Pratyusha Ghanta, U. Bhatnagar, S. Pasumarthi, Sunil Kumar Chiliveri","doi":"10.3923/JPT.2019.18.27","DOIUrl":"https://doi.org/10.3923/JPT.2019.18.27","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88968792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Ibeh, G. Ikechukwu, S. Ijioma, C. Nwankwo, Ashok K. Singh, M. Samani, S. Onoja, G. S. Aloh
{"title":"Anti-spasmolytic and Anti-diarrheal Activities of Newbouldia laevis, Cola nitida and Acanthus montanus Extracts on Gastrointestinal Muscles","authors":"R. Ibeh, G. Ikechukwu, S. Ijioma, C. Nwankwo, Ashok K. Singh, M. Samani, S. Onoja, G. S. Aloh","doi":"10.3923/JPT.2019.1.8","DOIUrl":"https://doi.org/10.3923/JPT.2019.1.8","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88820391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Obakiro, L. Bunalema, J. Gakunga-Nd, E. Nyatia, J. P. Waako
{"title":"Ulcerogenic Potential of Eucalyptus globulus L. Leaf Extract in Wistar Albino Rats","authors":"S. Obakiro, L. Bunalema, J. Gakunga-Nd, E. Nyatia, J. P. Waako","doi":"10.3923/JPT.2018.45.51","DOIUrl":"https://doi.org/10.3923/JPT.2018.45.51","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"11 1","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85687914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. AnuforoPhilemon, K. AchiNgozi, Anthony Cemaluk C. Egbuonu, Egu U. Elizabeth
{"title":"Determination of Some Phyto-constituents Present in Terminalia catappa Endocarp Flour and Biochemical Evaluation of its Ethanolic Extract on Hepatic Indices in Male Wistar Rats","authors":"C. AnuforoPhilemon, K. AchiNgozi, Anthony Cemaluk C. Egbuonu, Egu U. Elizabeth","doi":"10.3923/JPT.2018.27.36","DOIUrl":"https://doi.org/10.3923/JPT.2018.27.36","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"59 1","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90629990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Edouard, V. Narcisse, Nelo Chancel Patrick, M. F. Pascal, Kenfack Augustave, N. Ferdinand, Teguia Alexis
{"title":"Bersama engleriana (Melianthaceae) Extracts Alleviate Cypermethrin-induced Alteration of Haemato-biochemical Parameters in Male Guinea Pigs","authors":"N. Edouard, V. Narcisse, Nelo Chancel Patrick, M. F. Pascal, Kenfack Augustave, N. Ferdinand, Teguia Alexis","doi":"10.3923/JPT.2018.19.26","DOIUrl":"https://doi.org/10.3923/JPT.2018.19.26","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"12 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82804201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yong-Xiao Cao, M. Hui, Lu Wudang, Wei-Ping Yu, Tao Chen, Jing-liang Gu
{"title":"Pharmacokinetics and Toxicity of Oily Delivery System of Ropivacaine via Subcutaneous Injection in Beagle Dogs","authors":"Yong-Xiao Cao, M. Hui, Lu Wudang, Wei-Ping Yu, Tao Chen, Jing-liang Gu","doi":"10.3923/JPT.2018.37.44","DOIUrl":"https://doi.org/10.3923/JPT.2018.37.44","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"2 1","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88251319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The present study was carried out to investigate the protective effect of zinc against oxidative damage induced by fipronil (FPN) in the liver and kidney of male rats. Methodology: Rats were assigned to four groups and received, water (control group), fipronil at concentration 10 mg LG1 (2.0 mg kgG1 b.wt.), zinc at concentration 227 mg LG1 and fipronil plus zinc group. All treatments were administered through drinking water for 45 days. The concentration used of fipronil in this study represents 2.0 mg kgG1 b.wt., based on average water consumptions and body weights of treated rats. Results: Results revealed that fipronil induced insignificant changes in body weight and significant increase in liver weight of treated rats. Also, significant activities of oxidative stress enzymes such as, superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and level of glutathione reduced (GSH) were obtained. The FPN caused a significant elevation in lipid peroxidation level. However, the adverse effects induced by FPN were mitigated when the rats were supplemented with zinc. Moreover, three new protein bands were detected only in the electrophoretic pattern of the FPN treated group and disappeared in the remaining three groups; control, zinc and fipronil plus zinc. Conclusion: The overall outcome suggested that FPN induced adverse effects on oxidant/antioxidant status in the liver and kidney of intoxicated rats and zinc has a role in attenuating these effects. These outcome show that administration of Zn may be useful, easy and economical to protect human against phenyl pyrazole insecticide toxic effects.
{"title":"Ameliorating Effect of Zinc Against Oxidative Stress and Lipid Peroxidation Induced by Fipronil in Male Rats","authors":"E. S. Swelam, Ibrahim S. Abdallah, A. Mossa","doi":"10.3923/JPT.2017.24.32","DOIUrl":"https://doi.org/10.3923/JPT.2017.24.32","url":null,"abstract":"Objective: The present study was carried out to investigate the protective effect of zinc against oxidative damage induced by fipronil (FPN) in the liver and kidney of male rats. Methodology: Rats were assigned to four groups and received, water (control group), fipronil at concentration 10 mg LG1 (2.0 mg kgG1 b.wt.), zinc at concentration 227 mg LG1 and fipronil plus zinc group. All treatments were administered through drinking water for 45 days. The concentration used of fipronil in this study represents 2.0 mg kgG1 b.wt., based on average water consumptions and body weights of treated rats. Results: Results revealed that fipronil induced insignificant changes in body weight and significant increase in liver weight of treated rats. Also, significant activities of oxidative stress enzymes such as, superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and level of glutathione reduced (GSH) were obtained. The FPN caused a significant elevation in lipid peroxidation level. However, the adverse effects induced by FPN were mitigated when the rats were supplemented with zinc. Moreover, three new protein bands were detected only in the electrophoretic pattern of the FPN treated group and disappeared in the remaining three groups; control, zinc and fipronil plus zinc. Conclusion: The overall outcome suggested that FPN induced adverse effects on oxidant/antioxidant status in the liver and kidney of intoxicated rats and zinc has a role in attenuating these effects. These outcome show that administration of Zn may be useful, easy and economical to protect human against phenyl pyrazole insecticide toxic effects.","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"1 1","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84729650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed A. Abd-Rabou, M. Mwaheb, O. Sayed, Safaa H. Mohamed, Mohamed S. Kishta
{"title":"5-fluorouracil Synergized with Raloxifene and Cytosine β-D-arabinofuranoside to Combat Colorectal Cancers in vitro via Controlling Lipolysis","authors":"Ahmed A. Abd-Rabou, M. Mwaheb, O. Sayed, Safaa H. Mohamed, Mohamed S. Kishta","doi":"10.3923/JPT.2017.14.23","DOIUrl":"https://doi.org/10.3923/JPT.2017.14.23","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"26 1","pages":"14-23"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79115634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the Antidepressant Activity of Beta vulgaris Alone and in Combination with Fluoxetine in Mice","authors":"Mihir Invally, Ginpreet Kaur, H. Buttar","doi":"10.3923/JPT.2017.33.41","DOIUrl":"https://doi.org/10.3923/JPT.2017.33.41","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"1 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83053860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Tabassum, R. R. Saha, Minhazur Rahman, M. A. Nure, Rubaba Karim, A. Imon, M. Maniruzzam, A. L. Kabir, A. Islam, J. F. Chaity, Bikash Chandra Adhikary, Abeer Sarwar, Tamanna Binte Huq, Mst. Marium Begum
{"title":"Combined Paracetamol and Ibuprofen for the Study of Analgesic Activity of Newly Formulated Dose in Prospective Pain Management in Bangladesh","authors":"A. Tabassum, R. R. Saha, Minhazur Rahman, M. A. Nure, Rubaba Karim, A. Imon, M. Maniruzzam, A. L. Kabir, A. Islam, J. F. Chaity, Bikash Chandra Adhikary, Abeer Sarwar, Tamanna Binte Huq, Mst. Marium Begum","doi":"10.3923/JPT.2017.1.13","DOIUrl":"https://doi.org/10.3923/JPT.2017.1.13","url":null,"abstract":"","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"16 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2017-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85134979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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