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Comparison of nerve block and spinal anesthesia in second toe pulp free flap surgery for fingertip reconstruction. 比较神经阻滞和脊髓麻醉在第二趾髓内游离皮瓣手术中用于指尖重建的效果。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-30 DOI: 10.2340/jphs.v59.34020
Deok Hyeon Yu, Yunki Kim, Jiho Park

Toe pulp flap surgery is a viable option for soft tissue defects of the fingertips, effectively addressing patient needs and fingertip characteristics. The preferred anesthesia for lower-extremity surgery includes spinal and regional anesthesia. However, the choice between these methods depends on patient safety and surgical efficacy. In this retrospective study, we aimed to ascertain the optimal anesthetic technique by examining the efficacy, safety, pain control, and potential side effects of spinal and peripheral nerve block anesthetics. We included 40 patients aged 18-60 years who underwent partial second toe pulp free flap surgery for fingertip reconstruction. Twenty patients received spinal anesthesia (SA), while the remaining 20 received peripheral nerve block anesthesia. We conducted a comparative analysis of postoperative pain scores, adverse effects, analgesic usage, and patient satisfaction scores associated with each anesthesia method. Independent t-test, Mann-Whitney U test, and chi-squared test were performed. The SA group exhibited hypotension, bradycardia, urinary retention, and postdural puncture headache rates of 10%, 10%, 5%, and 5%, respectively. A significant difference in the timing of first analgesic use was observed (spinal, 3.7 ± 0.8 vs. peripheral nerve block, 13.2 ± 6.6; P = 0.006). Visual analog scale (VAS) scores of the patients at the 2nd, 4th, and 6th h were significantly lower in the peripheral nerve block group (P < 0.001, P < 0.001, P < 0.001, respectively). VAS scores at 12 and 24 h were similar between the groups (P = 0.07, P = 0.135, respectively). Peripheral nerve block anesthesia is superior to SA for partial second toe pulp free flap surgery, offering lower complication rates, reduced postoperative pain, and improved patient comfort.

趾髓瓣手术是治疗指尖软组织缺损的一种可行方法,能有效满足患者的需求和指尖的特点。下肢手术的首选麻醉方式包括脊髓麻醉和区域麻醉。然而,如何选择这两种方法取决于患者的安全性和手术效果。在这项回顾性研究中,我们旨在通过检查脊髓和周围神经阻滞麻醉剂的疗效、安全性、疼痛控制和潜在副作用来确定最佳麻醉技术。我们纳入了 40 名年龄在 18-60 岁之间、接受部分第二趾髓游离皮瓣手术以重建指尖的患者。其中 20 名患者接受了脊髓麻醉(SA),其余 20 名患者接受了周围神经阻滞麻醉。我们对每种麻醉方法的术后疼痛评分、不良反应、镇痛剂用量和患者满意度进行了比较分析。采用独立 t 检验、曼-惠特尼 U 检验和卡方检验。SA组出现低血压、心动过缓、尿潴留和硬膜穿刺后头痛的比例分别为10%、10%、5%和5%。首次使用镇痛药的时间存在明显差异(脊髓阻滞为 3.7 ± 0.8,周围神经阻滞为 13.2 ± 6.6;P = 0.006)。周围神经阻滞组患者在第 2、4 和 6 小时的视觉模拟量表(VAS)评分明显较低(分别为 P <0.001、P <0.001、P <0.001)。两组患者在 12 小时和 24 小时的 VAS 评分相似(分别为 P = 0.07、P = 0.135)。外周神经阻滞麻醉在部分第二趾髓质游离皮瓣手术中优于SA,并发症发生率低,术后疼痛减轻,患者更舒适。
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引用次数: 0
Spring-assisted posterior vault expansion in children over 2 years of age with craniosynostosis. 弹簧辅助后穹隆扩张术用于两岁以上的颅骨发育不良儿童。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-25 DOI: 10.2340/jphs.v59.41906
Karin Säljö, Madiha Bhatti-Søfteland, Peter Tarnow, Robert Olsson, Tobias Hallén, Wen-Chih Chao, Lars Kölby, Giovanni Maltese

Background: This study evaluated spring-assisted posterior vault expansion (SA-PVE) in children aged > 2 years with craniosynostosis and signs of high intracranial pressure (ICP).

Methods: We retrospectively analysed all consecutive patients aged > 2 years and operated with SA-PVE between 2018 and 2020 at the Craniofacial Center at Sahlgrenska University Hospital, Sweden. During the procedure, a circumferent occipital bone flap extending below the torcula was created and remained attached to the dura. Intracranial volumes (ICVs) were calculated from computed tomography (CT) images, and demographic data and information regarding symptoms and signs of high ICP were collected.

Results: The study included eight patients [Crouzon/Pfeiffer (n = 4), multiple craniosynostosis (n = 3), and secondary synostosis (n = 1)]. Median age at SA-PVE was 3.8 years (range: 2.5-12.8 years), and springs were removed after a median of 5.5 months (range: 2.3-8.3 months). The median operating time was 164 min (range: 102-221 min), and estimated blood loss was 4.5 mL/kg body weight (range: 1.4-59.1 mL/kg body weight), with 50% of patients receiving a blood transfusion. The median increase in ICV was 206 cm3 (range: 122-344 cm3) representing an 18.7% increase (range: 7.9-24.1%; p = 0.01). We observed no major perioperative complications, and symptoms related to high ICP were improved or absent at clinical follow-up.

Conclusion: These results demonstrated that SA-PVE involving creation of a large occipital bone flap including the torcula as a safe and effective surgical treatment in children aged >2 years with craniosynostosis and elevated ICP.

背景:本研究评估了弹簧辅助后穹隆扩张术(SA-PVE)在颅骨发育不良且有高颅内压(ICP)症状的2岁以上儿童中的应用:本研究评估了弹簧辅助后穹隆扩张术(SA-PVE)在颅骨发育不良且有高颅内压(ICP)症状的2岁以上儿童中的应用情况:我们回顾性分析了2018年至2020年间在瑞典萨赫格伦斯卡大学医院颅面中心接受SA-PVE手术的所有年龄大于2岁的连续患者。手术过程中,制作了一个延伸至穹窿下方的环枕骨瓣,并与硬脑膜保持连接。根据计算机断层扫描(CT)图像计算颅内容积(ICV),并收集人口统计学数据以及有关ICP过高的症状和体征的信息:研究包括 8 名患者[Crouzon/Pfeiffer(n = 4)、多发性颅骨突触症(n = 3)和继发性颅骨突触症(n = 1)]。SA-PVE的中位年龄为3.8岁(范围:2.5-12.8岁),取出弹簧的中位时间为5.5个月(范围:2.3-8.3个月)。中位手术时间为 164 分钟(范围:102-221 分钟),估计失血量为 4.5 毫升/千克体重(范围:1.4-59.1 毫升/千克体重),50% 的患者接受了输血。ICV 增加的中位数为 206 cm3(范围:122-344 cm3),增加了 18.7%(范围:7.9-24.1%;P = 0.01)。我们没有观察到严重的围手术期并发症,与高 ICP 相关的症状在临床随访中得到改善或消失:这些结果表明,对于年龄大于 2 岁的颅骨发育不良和 ICP 升高患儿,SA-PVE 是一种安全有效的手术治疗方法。
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引用次数: 0
Efficacy and safety of volar locking plate versus cast immobilization for distal radius fractures: a systematic review and meta-analysis of randomized controlled trials. 桡骨远端骨折的外侧锁定钢板与石膏固定的有效性和安全性:随机对照试验的系统回顾和荟萃分析。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-23 DOI: 10.2340/jphs.v59.41372
Faxiang Li, Yuzhong Tan, Liuchao Cui, Lin Tian

Volar locking plates (VLPs) are increasingly used for distal radius fractures (DRFs), yet their efficacy compared to cast immobilization remains debated. This meta-analysis aimed to compare VLPs versus cast immobilization for DRFs across various follow-up durations. Randomized controlled trials reporting patient-reported functional scores, wrist range of motion (ROM), radiological assessments, and complications were included. Meta-analysis was performed for 6-week, 3-month, 6-month, 12-month, and >12-month follow-ups. Subgroup analysis stratified studies by age group, ≥ 60 years and < 60 years. VLPs showed significantly lower Disabilities of the Arm, Shoulder, and Hand (DASH) scores at 6 weeks (p < 0.001), 3 months (p < 0.001), 12 months (p = 0.012), and > 12 months (p < 0.001), and lower PRWE scores at 6 weeks (p < 0.001), 3 months (p = 0.048), and >12 months (p = 0.032). Wrist ROM favored VLPs at 6 weeks (p < 0.05), with higher flexion and supination at 3 months (p = 0.027) and 12 months (p = 0.003). Radiologically, VLPs showed improved parameters at 3- and 12-month follow-up. Overall complications did not significantly differ. Subgroup analysis in patients < 60 years generally supported these findings, while in patients ≥ 60 years, radiological outcomes aligned, yet only lower DASH scores were observed with VLPs at 3 months (p < 0.001). VLPs may offer superior clinical, functional, and radiological outcomes compared to cast immobilization at 3- and 12-month follow-up for patients < 60 years, with comparable safety profiles. For patients ≥ 60 years, VLPs may yield better radiological outcomes at 3- and 12-month follow-up, though clinical benefits remain uncertain.

桡骨远端骨折(DRFs)越来越多地使用沃尔锁定板(VLPs),但与石膏固定相比,其疗效仍存在争议。本荟萃分析旨在比较VLP与石膏固定在不同随访时间内治疗桡骨远端骨折的效果。纳入的随机对照试验报告了患者报告的功能评分、腕关节活动范围(ROM)、放射学评估和并发症。对6周、3个月、6个月、12个月和>12个月的随访进行了元分析。分组分析按年龄组、≥ 60 岁和 12 个月对研究进行了分层(p 12 个月(p = 0.032))。6周时,VLPs的腕关节活动度更好(p < 0.05),3个月(p = 0.027)和12个月(p = 0.003)时,腕关节屈曲和上举度更高。从放射学角度来看,VLPs在3个月和12个月的随访中显示出更好的参数。总体并发症无明显差异。患者分组分析
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引用次数: 0
Experimental study of contrast-enhanced ultrasound in the evaluation of random-pattern flap blood supply in the early postoperative stage in rats. 对比增强超声波在大鼠术后早期评估随机模式皮瓣供血的实验研究。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-09-09 DOI: 10.2340/jphs.v59.39975
Jian-Xun Ma, You-Chen Xia, Zhi-Yong Bai, Hua-Bin Zhang, Xia Xie

Purpose: This study aims to investigate whether contrast-enhanced ultrasound (CEUS) could be used to reveal the status of blood supply of the superficial flap of rat model in the early postoperative stage.

Methods: One viable and one ischemic random-pattern flap were prepared on the left and right back of the same rat respectively with a number of 40. CEUS examinations were applied within 12 h and 7 days postoperatively, and the quantitative measurements of microvascular blood volume (BV) of the base and the end of both flaps were expressed using acoustic intensity as a ratio to that of the healthy skin.

Results: Within 12 h post operation, there was a smaller BV value of the ischemic ends than that of both the ischemic bases and viable ends (p < 0.001), while no difference was indicated between ischemic bases and viable bases or between viable bases and viable ends. The same result was provided 7 days post operation.

Conclusion: Microcirculation of superficial tissues such as random-pattern flaps in this rat model can be assessed quantitatively by CEUS. It could sensitively and accurately reveal the objective status of tissue perfusion in the early postoperative stage.

目的:本研究旨在探讨对比增强超声(CEUS)是否可用于揭示大鼠模型浅表皮瓣术后早期的血供状况:方法:在同一只大鼠的左背部和右背部分别制备一个存活和一个缺血的随机模式皮瓣,数量为 40 个。方法:在同一只大鼠的左背部和右背部分别制备一个存活的和一个缺血的随机图案皮瓣,数量为 40 个,分别在术后 12 小时和 7 天内进行 CEUS 检查,用声强与健康皮肤的比值来表示两个皮瓣基底和末端微血管血容量(BV)的定量测量结果:结果:术后 12 小时内,缺血末端的 BV 值小于缺血基底和存活末端的 BV 值(p 结论:术后 12 小时内,缺血基底和存活末端的 BV 值均小于缺血基底和存活末端的 BV 值:该大鼠模型中随机模式皮瓣等浅表组织的微循环可通过 CEUS 进行定量评估。它可以灵敏、准确地揭示术后早期组织灌注的客观状况。
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引用次数: 0
Clinical efficacy of Ni-Ti memory alloy four-corner arthrodesis concentrator in the treatment of scaphoid nonunion advanced collapse: a follow-up of over 10 years. 镍钛记忆合金四角关节置换集中器治疗肩胛骨未愈合晚期塌陷的临床疗效:超过 10 年的随访。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-08-29 DOI: 10.2340/jphs.v59.40353
Baochuang Qi, Minzheng Guo, Chen Meng, Teng Wang, Chuan Li, Yongqing Xu

Purpose: Exploring the therapeutic effects of Ni-Ti shape memory alloy four-corner arthrodesis concentrator (NT-FCAC) in treating scaphoid nonunion advanced collapse (SNAC) and providing a decade-long follow-up report.

Materials and methods: Twenty-six patients with SNAC underwent scaphoidectomy, along with four-corner arthrodesis fusion involving the capitate, lunate, triquetrum, and hamate, using NT-MFCAC. Grip strength was measured using a Jamar dynamometer, while wrist joint mobility was assessed using a goniometer. Preoperative and postoperative assessments were conducted using the Quick Disabilities of the Arm, Shoulder, and Hand (Quick DASH) questionnaire to monitor limb functionality restoration. Pain levels at the wrist joint were evaluated using the visual analog scale (VAS). Postoperative wrist bone fusion status was assessed through anteroposterior and lateral radiographs of the wrist joint.

Results: After a 3-month postoperative period, all 26 patients exhibited osseous union at the wrist joint. Over a follow-up spanning 10-15 years, no severe postoperative complications were observed in any patient. Grip strength in the affected side of all patients recovered to 81.96% compared to the healthy side, while wrist joint mobility in the affected side reached over 60% of the healthy side's functionality. VAS scores decreased significantly from 5.85 ± 0.73 preoperatively to 0.19 ± 0.40 at the final follow-up; Quick DASH scores reduced from 69.88 ± 5.12 preoperatively to 6.30 ± 1.25 at final follow-up. Statistically significant differences were noted in VAS and Quick DASH scores for all patients (p < 0.05). However, beyond 60 months postoperatively, subsequent follow-ups did not yield statistically significant differences in VAS and Quick DASH scores for all patients (p > 0.05).

Conclusions: Utilizing NT-FCAC for SNAC treated with four-corner arthrodesis fusion results in a high rate of wrist bone fusion, preserving a significant portion of wrist joint function and exhibiting favorable long-term outcomes. This approach is suitable for treating patients with SNAC requiring four-corner arthrodesis fusion.

目的:探讨镍钛形状记忆合金四角关节融合集中器(NT-FCAC)在治疗肩胛骨未愈合晚期塌陷(SNAC)中的疗效,并提供一份长达十年的随访报告:26名SNAC患者接受了肩胛骨切除术,并使用NT-MFCAC进行了涉及头状、新月、三槌和锤骨的四角关节融合术。使用贾马尔测力计测量握力,使用动态关节角度计评估腕关节活动度。术前和术后评估采用快速手臂、肩部和手部残疾(Quick DASH)问卷,以监测肢体功能的恢复情况。腕关节疼痛程度采用视觉模拟量表(VAS)进行评估。术后腕关节骨融合状况通过腕关节的正位和侧位X光片进行评估:结果:术后 3 个月后,所有 26 名患者的腕关节都出现了骨结合。在长达 10-15 年的随访中,没有发现任何严重的术后并发症。与健侧相比,所有患者患侧的握力恢复到 81.96%,患侧腕关节活动度达到健侧的 60%以上。VAS 评分从术前的 5.85 ± 0.73 显著降至最终随访时的 0.19 ± 0.40;快速 DASH 评分从术前的 69.88 ± 5.12 降至最终随访时的 6.30 ± 1.25。所有患者的 VAS 和 Quick DASH 评分均有明显统计学差异(P < 0.05)。然而,在术后60个月后,所有患者的VAS和Quick DASH评分在随后的随访中均未出现统计学意义上的显著差异(P > 0.05):结论:使用NT-FCAC治疗四角关节融合术治疗的SNAC患者,腕骨融合率高,保留了大部分腕关节功能,长期疗效良好。这种方法适用于治疗需要进行四角关节融合术的SNAC患者。
{"title":"Clinical efficacy of Ni-Ti memory alloy four-corner arthrodesis concentrator in the treatment of scaphoid nonunion advanced collapse: a follow-up of over 10 years.","authors":"Baochuang Qi, Minzheng Guo, Chen Meng, Teng Wang, Chuan Li, Yongqing Xu","doi":"10.2340/jphs.v59.40353","DOIUrl":"https://doi.org/10.2340/jphs.v59.40353","url":null,"abstract":"<p><strong>Purpose: </strong>Exploring the therapeutic effects of Ni-Ti shape memory alloy four-corner arthrodesis concentrator (NT-FCAC) in treating scaphoid nonunion advanced collapse (SNAC) and providing a decade-long follow-up report.</p><p><strong>Materials and methods: </strong>Twenty-six patients with SNAC underwent scaphoidectomy, along with four-corner arthrodesis fusion involving the capitate, lunate, triquetrum, and hamate, using NT-MFCAC. Grip strength was measured using a Jamar dynamometer, while wrist joint mobility was assessed using a goniometer. Preoperative and postoperative assessments were conducted using the Quick Disabilities of the Arm, Shoulder, and Hand (Quick DASH) questionnaire to monitor limb functionality restoration. Pain levels at the wrist joint were evaluated using the visual analog scale (VAS). Postoperative wrist bone fusion status was assessed through anteroposterior and lateral radiographs of the wrist joint.</p><p><strong>Results: </strong>After a 3-month postoperative period, all 26 patients exhibited osseous union at the wrist joint. Over a follow-up spanning 10-15 years, no severe postoperative complications were observed in any patient. Grip strength in the affected side of all patients recovered to 81.96% compared to the healthy side, while wrist joint mobility in the affected side reached over 60% of the healthy side's functionality. VAS scores decreased significantly from 5.85 ± 0.73 preoperatively to 0.19 ± 0.40 at the final follow-up; Quick DASH scores reduced from 69.88 ± 5.12 preoperatively to 6.30 ± 1.25 at final follow-up. Statistically significant differences were noted in VAS and Quick DASH scores for all patients (p < 0.05). However, beyond 60 months postoperatively, subsequent follow-ups did not yield statistically significant differences in VAS and Quick DASH scores for all patients (p > 0.05).</p><p><strong>Conclusions: </strong>Utilizing NT-FCAC for SNAC treated with four-corner arthrodesis fusion results in a high rate of wrist bone fusion, preserving a significant portion of wrist joint function and exhibiting favorable long-term outcomes. This approach is suitable for treating patients with SNAC requiring four-corner arthrodesis fusion.</p>","PeriodicalId":16847,"journal":{"name":"Journal of Plastic Surgery and Hand Surgery","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of injury area on the success of treatment in digital nerve injury. 损伤面积对数字神经损伤治疗成功率的影响。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-26 DOI: 10.2340/jphs.v59.40519
Numan Atilgan

Introduction: The main objective of the current study is to investigate variations in postoperative outcomes that follow digital nerve repair in Zone 1 and Zone 2, respectively. We hope that by carrying out this investigation, we will be able to identify which zone has better sensation recovery and patient-reported outcomes, allowing us to identify the best way of conducting surgery for specific types of injuries.

Materials and methods: A retrospective cohort study was conducted in patients with digital nerve injuries treated in a designated hand surgery clinic between January 2021 and December 2023. The study was guided by ethical consideration, where all participants gave their informed consent. Surgical interventions involved primary repair, autograft/allograft nerve grafting, nonsurgical approaches, as well as conduit repair in which results were determined using objective measures and patient feedback.

Results: Direct repair emerged superior among injuries of Zone 1 and Zone 2 with high success rates and good patient-reported outcomes. In general, injuries in Zone 1 had better sensory recovery than injuries in Zone 2 and this was associated with higher levels of satisfaction. Comparisons using statistical methods confirmed that direct repair outperformed other modalities.

Conclusion: More importantly, the comparison of this study shows that repairs in Zone 1 are more successful than those in Zone 2 revealing direct repair as a superior method for digital nerve injuries. The difference is crucial because it suggests that surgical efficiency may depend on where the injury is. This means that direct repair should be given priority over the two zones, although surgeons will need to watch out for challenges related to Zone 2 injuries and adjust their strategies accordingly to obtain the best patient outcomes possible.

简介本研究的主要目的是调查分别在 1 区和 2 区进行数字神经修复术后效果的差异。我们希望通过这项调查,能够确定哪个区域的感觉恢复和患者报告结果更好,从而确定针对特定类型损伤的最佳手术方式:对 2021 年 1 月至 2023 年 12 月期间在指定手外科诊所接受治疗的数字神经损伤患者进行了一项回顾性队列研究。该研究以伦理为指导,所有参与者均已知情同意。手术干预包括初次修复、自体/异体神经移植、非手术方法以及导管修复,其结果通过客观测量和患者反馈来确定:结果:在1区和2区的损伤中,直接修复效果更佳,成功率高,患者反馈结果良好。一般来说,1区的损伤比2区的损伤有更好的感觉恢复,这与更高的满意度有关。使用统计方法进行的比较证实,直接修复的效果优于其他方式:更重要的是,这项研究的比较结果表明,1 区的修复比 2 区的修复更成功,这表明直接修复是治疗数字神经损伤的最佳方法。这一差异至关重要,因为它表明手术效率可能取决于损伤部位。这意味着直接修复应优先于两个区域,但外科医生需要注意与 2 区损伤相关的挑战,并相应调整策略,以尽可能获得最佳的患者疗效。
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引用次数: 0
Breast volume in non-obese females is related to breast adipose cell hypertrophy, inflammation, and COX2 expression. 非肥胖女性的乳房体积与乳腺脂肪细胞肥大、炎症和 COX2 表达有关。
IF 1 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-05 DOI: 10.2340/jphs.v59.40754
Silvia Gogg, Annika Nerstedt, Ulf Smith, Emma Hansson

Background: Breast hypertrophy seems to be a risk factor for breast cancer and the amount and characteristics of breast adipose tissue may play important roles. The main aim of this study was to investigate associations between breast volume in normal weight women and hypertrophic adipose tissue and inflammation.

Methods: Fifteen non-obese women undergoing breast reduction surgery were examined. Breast volume was measured with plastic cups and surgery was indicated if the breast was 800 ml or larger according to Swedish guidelines. We isolated adipose cells from the breasts and ambient subcutaneous tissue to measure cell size, cell inflammation and other known markers of risk of developing breast cancer including COX2 gene activation and MAPK, a cell proliferation regulator.

Results: Breast adipose cell size was characterized by cell hypertrophy and closely related to breast volume. The breast adipose cells were also characterized by being pro-inflammatory with increased IL-6, IL-8, IL-1β, CCL-2, TNF-a and an increased marker of cell senescence GLB1/β-galactosidase, commonly increased in hypertrophic adipose tissue. The prostaglandin synthetic marker COX2 was also increased in the hypertrophic cells and COX2 has previously been shown to be an important marker of risk of developing breast cancer. Interestingly, the phosphorylation of the proliferation marker MAPK was also increased in the hypertrophic adipose cells.

Conclusion: Taken together, these findings show that increased breast volume in non-obese women is associated with adipose cell hypertrophy and dysfunction and characterized by increased inflammation and other markers of increased risk for developing breast cancer.

Trial registration: Projektdatabasen FoU i VGR, project number: 249191 (https://www.researchweb.org/is/vgr/project/249191).

背景:乳房肥大似乎是乳腺癌的一个危险因素,而乳房脂肪组织的数量和特征可能起着重要作用。本研究的主要目的是调查正常体重女性的乳房体积与肥大脂肪组织和炎症之间的关系:方法:研究了 15 名接受乳房缩小手术的非肥胖女性。用塑料杯测量乳房体积,根据瑞典指南,如果乳房体积大于或等于 800 毫升,则应进行手术。我们从乳房和周围皮下组织中分离出脂肪细胞,测量细胞大小、细胞炎症和其他已知的乳腺癌发病风险标志物,包括 COX2 基因激活和细胞增殖调节因子 MAPK:结果:乳房脂肪细胞的大小以细胞肥大为特征,与乳房体积密切相关。乳腺脂肪细胞还具有促炎特征,IL-6、IL-8、IL-1β、CCL-2、TNF-a 增加,细胞衰老标志物 GLB1/β-半乳糖苷酶增加,这在肥大脂肪组织中常见。肥大细胞中的前列腺素合成标志物 COX2 也增加了,而 COX2 以前曾被证明是罹患乳腺癌风险的重要标志物。有趣的是,增生标志物 MAPK 的磷酸化在肥大的脂肪细胞中也有所增加:综上所述,这些研究结果表明,非肥胖女性的乳房体积增大与脂肪细胞肥大和功能障碍有关,其特点是炎症和其他标志物增加,从而增加了罹患乳腺癌的风险:Projektdatabasen FoU i VGR,项目编号:249191 (https://www.researchweb.org/is/vgr/project/249191)。
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引用次数: 0
Proximal row carpectomy versus four-corner arthrodesis: a retrospective comparative study. 近端排骨切除术与四角关节固定术:一项回顾性比较研究。
IF 1.2 4区 医学 Q2 Medicine Pub Date : 2024-05-20 DOI: 10.2340/jphs.v59.18338
Richard Chan, Justine Goursat, Mathilde Payen, Matthieu Lalevée, Kamel Guelmi

Background: Four-corner arthrodesis with scaphoid excision (FCA) and proximal row carpal resection (PRC) are frequently performed in wrists with post-traumatic Scaphoid Non- Union Advanced Collapse (SNAC)/Scapho-Lunate Advanced Collapse (SLAC) osteoarthritis. The aim of this study was to compare the clinical outcomes of these two procedures.

Methods: This single-center, retrospective cohort study included all patients who had PRC or FCA between January 1st, 2009 and January 1st, 2019 and who were followed up. Follow-up included: mobility (radial deviation, ulnar deviation, flexion, extension), strength (grip test, pinch test), function (QuickDash, patient-rated wrist evaluation [PRWE]), subjective mobility, and global satisfaction scores.

Results: Among 25 patients included, 11 had PRC and 14 had FCA with a mean follow-up of 69.5 months [12-132]. Radial deviation was 18° versus 14° (p = 0.7), ulnar deviation was 21° versus 22° (p = 0.15), flexion was 39° versus 30° (p = 0.32), extension was 32.5° versus 29.5° (p = 0.09), grip test compared to the controlateral side was 72% versus 62% (p = 0.53), Quick Dash score was 12.5 versus 17.6 (p = 0.84), PRWE was 18.7 versus 17.6 (p = 0.38), subjective mobility was 7.8 versus 7.5 (p = 0.23), and satisfaction score was 8.7 versus 9 (p = 0.76), respectively, in the FCA group and the PRC group. Re-operation rates were 14% patients in the FCA group and 0% in the PRC group.

Conclusion: This study found no significant difference between FCA and PRC on strength, mobility, and function in patients with post-traumatic SLAC or SNAC stage II wrist arthritis. Both FCA and PRC seem to be reliable surgical techniques with good outcomes with more revision in the FCA group.

背景:肩胛骨非联合晚期塌陷(SNAC)/肩胛-月骨晚期塌陷(SLAC)骨关节炎患者的腕关节经常需要进行肩胛骨切除四角关节固定术(FCA)和腕关节近端行切除术(PRC)。本研究旨在比较这两种手术的临床效果:这项单中心回顾性队列研究纳入了2009年1月1日至2019年1月1日期间接受PRC或FCA手术并接受随访的所有患者。随访内容包括:活动度(桡侧偏移、尺侧偏移、屈曲、伸展)、力量(握力测试、捏力测试)、功能(QuickDash、患者评定的腕部评估[PRWE])、主观活动度和总体满意度评分:在纳入的 25 名患者中,11 人患有 PRC,14 人患有 FCA,平均随访时间为 69.5 个月 [12-132]。桡偏差为18°对14°(P = 0.7),尺偏差为21°对22°(P = 0.15),屈曲为39°对30°(P = 0.32),伸展为32.5°对29.5°(P = 0.09),与对照侧相比,握力测试为72%对62%(P = 0.53),快速冲刺评分(Quick Dash)为0.5分。FCA组和PRC组的快速冲刺评分分别为12.5分和17.6分(P = 0.84),PRWE分别为18.7分和17.6分(P = 0.38),主观活动度分别为7.8分和7.5分(P = 0.23),满意度分别为8.7分和9分(P = 0.76)。FCA组和PRC组患者的再次手术率分别为14%和0%:本研究发现,FCA 和 PRC 对创伤后 SLAC 或 SNAC II 期腕关节炎患者的力量、活动度和功能没有明显差异。FCA和PRC似乎都是可靠的手术技术,疗效良好,但FCA组的翻修率更高。
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引用次数: 0
Autologous fat transplantation prior to permanent expander implant breast reconstruction enhances the outcome after two years: a randomized controlled trial. 在永久扩张假体乳房再造术前进行自体脂肪移植可提高两年后的效果:随机对照试验。
IF 1.2 4区 医学 Q2 Medicine Pub Date : 2024-05-20 DOI: 10.2340/jphs.v59.18622
Anna Lindegren, Inkeri Schultz, Åsa Edsander-Nord, Jacinth Yan, Marie Wickman

Radiotherapy is important in breast cancer treatment. A side effect of the treatment is fibrosis that decreases the possibility for a successful breast reconstruction with expanders and with high patient satisfaction with the result. The most common option for mastectomized, irradiated women wishing for a breast reconstruction is autologous tissue transplantation. However, some patients are not suitable for flap surgery. Fifty mastectomized and irradiated women were included in a randomized controlled trial. They underwent breast reconstruction with expanders and were allocated 1:1 to either receive pre-treatment with autologous fat transplantation (AFT) or not. Primary outcomes were frequency of reoperations and complications. Secondary outcomes were number of days in hospital, number of outpatient visits to surgeon or nurse and patient reported outcome as reported with Breast Q. Follow-up time was 2 years. Fifty-two per cent of the intervention group and 68% of the controls underwent reoperations (p = 0.611). Thirty-two per cent of the intervention group and 52% of the controls had complications (p = 0.347). The median number of consultations with the nurse was four in the intervention group and six in the control group (p = 0.002). The AFT patients were significantly more satisfied with their breasts and psychosocial well-being after 2 years. They also had higher increase in satisfaction with breasts, psychosocial well-being, and sexual well-being when comparing baseline with 2 years postoperatively. This randomized controlled trial indicates benefits of AFT prior to breast reconstruction with expanders, especially on patient reported outcome even if the study sample is small.

放疗在乳腺癌治疗中非常重要。治疗的副作用之一是纤维化,这降低了使用扩张器成功重建乳房的可能性,也降低了患者对结果的满意度。对于切除乳房、接受过放射治疗的妇女来说,最常见的乳房重建方法是自体组织移植。然而,有些患者并不适合皮瓣手术。一项随机对照试验纳入了 50 名切除乳房和接受过放射治疗的妇女。她们接受了扩张器乳房重建手术,并按 1:1 的比例被分配接受或不接受自体脂肪移植(AFT)预处理。主要结果是再次手术的频率和并发症。次要结果是住院天数、门诊看外科医生或护士的次数,以及患者通过乳房 Q 报告的结果。52%的干预组患者和68%的对照组患者接受了再次手术(P = 0.611)。32%的干预组和 52% 的对照组出现了并发症(p = 0.347)。干预组和对照组的护士咨询次数中位数分别为 4 次和 6 次(p = 0.002)。两年后,AFT 患者对乳房和社会心理健康的满意度明显提高。将基线与术后 2 年进行比较,她们对乳房、社会心理健康和性健康的满意度也有更高的提升。这项随机对照试验表明,在使用扩张器进行乳房重建之前进行 AFT 有好处,尤其是在患者报告的结果方面,即使研究样本较少。
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引用次数: 0
Limited debridement combined with ReCell® Techniques for deep second-degree burns. 有限清创结合 ReCell® 技术治疗深二度烧伤。
IF 1.2 4区 医学 Q2 Medicine Pub Date : 2024-05-20 DOI: 10.2340/jphs.v59.24557
Yue Zhang, Kai Guo, Chenyang Tian, Ling Tong, Dahai Hu, Yunchuan Wang

Background: The purpose of this article is to introduce a method that combines limited debridement and ReCell® autologous cell regeneration techniques for the treatment of deep second-degree burn wounds.

Method: A total of 20 patients suffered with deep second-degree burns less than 10% of total body surface area (TBSA) who were admitted to our department, from June 2019 to June 2021, participated in this study. These patients first underwent limited debridement with an electric/pneumatic dermatome, followed by the ReCell® technique for secondary wounds. Routine treatment was applied to prevent scarring after the wound healed. Clinical outcomes were scored using the Vancouver Scar Scale (VSS).

Results: All wounds of the patients healed completely. One patient developed an infection in the skin graft area and finally recovered by routine dressing changes. The average healing time was 12 days (range: 10-15 days). The new skin in the treated area was soft and matched the colour of the surrounding normal skin and the VSS score ranged from 3~5 for each patient. Of the 20 patients, 19 were very satisfied and 1 was satisfied.

Conclusions: This article reports a useful treatment method that combines electric dermatome-dependent limited debridement and the ReCell® technique for the treatment of deep second-degree burn wounds. It is a feasible and effective strategy that is easy to implement and minimally invasive, and it is associated with a short healing time, mild scar formation and little damage to the donor skin area.

背景:本文旨在介绍一种结合有限清创和ReCell®自体细胞再生技术治疗深二度烧伤创面的方法:2019年6月至2021年6月期间,我科共收治了20名深度二度烧伤患者,其烧伤面积小于体表总面积(TBSA)的10%。这些患者首先使用电动/气动皮肤刀进行了有限的清创,然后使用 ReCell® 技术处理了继发性伤口。伤口愈合后进行常规治疗以防止疤痕形成。临床结果采用温哥华疤痕量表(VSS)进行评分:结果:所有患者的伤口均完全愈合。结果:所有患者的伤口均完全愈合,其中一名患者的植皮区域出现感染,最终通过常规换药痊愈。平均愈合时间为 12 天(范围:10-15 天)。治疗区域的新皮肤柔软,颜色与周围正常皮肤一致,每位患者的 VSS 评分在 3 至 5 分之间。20 名患者中,19 人非常满意,1 人满意:本文报道了一种有效的治疗方法,该方法结合了依赖于皮肤组织的电动有限清创和 ReCell® 技术,用于治疗深二度烧伤创面。这是一种可行且有效的策略,易于实施,创伤小,愈合时间短,疤痕形成轻微,对供体皮肤区域损伤小。
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引用次数: 0
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Journal of Plastic Surgery and Hand Surgery
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