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Proceedings. 2005 First International Conference on Neural Interface and Control, 2005.最新文献

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Immunohistochemical localization of the corticospinal tract in normal rat spinal cord as a stereotactic guidance for implantation of microelectronic chip 正常大鼠脊髓皮质脊髓束的免疫组织化学定位作为微电子芯片植入的立体定向指导
Luo Guangming, L. Dongmei, Jiang Zhenglin, D. Fei, Gu Xiaosong, Wang Zhigong
In order to investigate the pick-up, the process and the regeneration of central neural signals for neural function regeneration by means of microelectronic techniques, it is necessary to do a more detailed investigation, primarily of the stereotactic anatomical bases of corticospinal tract (CST). In present study, we use a polyclonal antibody against protein kinase C gamma subspecies (PKC /spl gamma/) as a specific marker of CST to reveal the precise localization of CST in rat spinal cord by immunohistochemistry. The strong PKC /spl gamma/ immunoreactivities in axons of CST were found in the pyramid and pyramidal decussation of medulla oblongata, and then from the cervical to lumbar spinal cord, PKC /spl gamma/ immunoreactivities were found to descend caudully through the white matter occupying the ventralmost portion of the posterior funiculus. At the conus medullaris, the positive reactivities of PKC /spl gamma/ appeared at the midline of the posterior funiculus. The area of positive reactivities of PKC /spl gamma/ decreased in size caudally in different spinal cord segments. These findings suggest that PKC /spl gamma/ immunohistochemical method can show the accurate position of corticospinal tract in rat spinal cord clearly, and provide the stereotactic anatomical bases for the microelectronic chip implantation in spinal cord.
为了研究微电子技术在神经功能再生中中枢神经信号的提取、过程和再生,有必要对皮质脊髓束(CST)的立体定向解剖学基础进行更详细的研究。本研究利用一种抗蛋白激酶C γ亚种的多克隆抗体(PKC /spl γ /)作为CST的特异性标记物,通过免疫组织化学方法揭示了CST在大鼠脊髓中的精确定位。CST轴突的PKC /spl γ /免疫反应在延髓锥体和锥体部可见,然后从颈髓到腰椎,PKC /spl γ /免疫反应在后索腹侧白质处呈尾侧下降。在髓圆锥处,后索中线出现PKC /spl γ /阳性反应。不同脊髓节段PKC /spl γ /阳性反应区呈尾侧减小。上述结果提示,PKC /spl γ /免疫组化方法可清晰显示大鼠脊髓皮质脊髓束的准确位置,为脊髓微电子芯片植入提供立体定向解剖学依据。
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引用次数: 1
Multisensor data fusion and control for complex neural interface system 复杂神经接口系统的多传感器数据融合与控制
Pan Wei, Weihua Li
Neural Interface (NI) technology has been an area of intense recent research and development activity. Signal and information management of neural recordings for complex neural interface system become a very difficult task. Recently we develop a framework for complex neural interface system aimed at processing neural signals with multisensor fusion approaches. The relationship of the data fusion with the whole system is detailed discussed. A general fusion and control architecture for complex neural interface system is proposed. In this work, using the proposed approach we make an illustrative experiment by exploiting the Sleep Heart Health Study Polysomnography (SHHS) Database to seek to integrate with the ECG, EEG, EOG and other neural signals, and propose a good solution to the investigation of clinical neural medicine.
神经接口(NI)技术是近年来研究和发展活跃的一个领域。对于复杂的神经接口系统,神经记录的信号和信息管理是一个非常困难的任务。最近,我们开发了一个复杂神经接口系统框架,旨在用多传感器融合方法处理神经信号。详细讨论了数据融合与整个系统的关系。提出了一种用于复杂神经接口系统的通用融合与控制体系结构。本文利用该方法,利用睡眠心脏健康研究多导睡眠图(SHHS)数据库进行说明性实验,寻求与ECG、EEG、EOG等神经信号的整合,为临床神经医学的研究提供一个较好的解决方案。
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引用次数: 0
A conceptual brain machine interface system 概念脑机接口系统
O. Byron, J. He, J. Hu, J. Si
While even a single bit output can impart a great deal of improvement in quality of life to patients, a richer vocabulary could obviously mean an even greater degree of control. This paper discusses ideas about extending previous results of using a support vector machine (SVM) based brain machine interface (BMI) to include multiple directions and magnitudes. It also investigates the number of neurons needed to create an accurate two direction result.
虽然即使是一个比特的输出也能极大地改善患者的生活质量,但更丰富的词汇显然意味着更大程度的控制。本文讨论了将基于支持向量机(SVM)的脑机接口(BMI)的先前结果扩展到包括多个方向和量级的想法。它还研究了产生精确的双向结果所需的神经元数量。
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引用次数: 5
Modeling and application of multimodal affective user interface with multimedia computer sensing 基于多媒体计算机感知的多模态情感用户界面建模与应用
Z. Jianzhong, Jia Shan, Cao Peipei, Yang Yuankui, Wang Xunheng
Emotions play an important role in people's everyday life. It's desirable to create intelligent computer systems that understand users' emotional states. In this paper we report on our efforts in developing multimodal affective user interface system used in emotion assessment. First, we discuss the importance of emotion research. Secondly, we introduce the prototype MAUI system built in BABYLAB. There are different modalities of synchronous inputs from the user using wireless sensors and multimedia computer sensing, including physiological signals, facial expressions, speech signals, and behavioral data. The physiological signals are collected using wireless remote sensors in real time. The images of facial expression and the ongoing videos of behavior and gesture are recorded by several cameras connected to different controlling computers. Signals captured simultaneously during experiments are saved in order to discern emotional state from processing sensory modalities over time. All these signals and experiments are collected synchronously in real time to make multimodal signal analysis convenient. Then, using this system, we present preliminary results from an exploratory study that aims to estimate emotion state with non-invasive technologies, which are mapped to their corresponding emotions. Finally, we discuss usages of this system in educational area, and people may benefit from improved satisfaction in learning and training.
情感在人们的日常生活中扮演着重要的角色。人们希望创造出能够理解用户情绪状态的智能计算机系统。在本文中,我们报告了我们在开发用于情绪评估的多模态情感用户界面系统方面所做的努力。首先,我们讨论了情绪研究的重要性。其次,我们介绍了在BABYLAB中构建的MAUI原型系统。使用无线传感器和多媒体计算机传感的用户有不同的同步输入方式,包括生理信号、面部表情、语音信号和行为数据。利用无线遥感器实时采集生理信号。面部表情的图像以及行为和手势的持续视频由连接到不同控制计算机的几个摄像头记录。在实验过程中同时捕获的信号被保存下来,以便从处理感觉模态中辨别情绪状态。所有这些信号和实验都是实时同步采集的,便于对多模态信号进行分析。然后,利用该系统,我们提出了一项探索性研究的初步结果,该研究旨在利用非侵入性技术估计情绪状态,并将其映射到相应的情绪上。最后,讨论了该系统在教育领域的应用,提高了人们的学习和培训满意度。
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引用次数: 2
Adaboost for improving classification of left and right hand motor imagery tasks Adaboost用于改进左手和右手运动想象任务的分类
Pei Xiaomei, Z. Chong-xun, Xu Jin, Bin Guangyu
The Adaboost classifier with Fisher discriminant analysis (FDA) as base learner is proposed to discriminate the left and right hand motor imagery tasks in this paper. Firstly, multichannel complexity and held power of EEG within 10-12Hz over two brain hemispheres are extracted as feature vectors, which characterize the brain features during hand motor imagination. Then with the Adaboost classifier, the satisfactory classification results on test data can be obtained. The maximum classification accuracy reaches to 89.29% and the maximum mutual information is 0.59bit. The primary results show that the Adaboost could effectively improve the classification accuracy of left and right hand motor imagery tasks, so that it has great potentials to mental tasks classification for BCI.
本文提出了以Fisher判别分析(FDA)为基础学习器的Adaboost分类器,用于区分左手和右手运动意象任务。首先,提取两个脑半球10-12Hz范围内脑电信号的多通道复杂度和保持功率作为特征向量,表征手部运动想象过程中的大脑特征;然后利用Adaboost分类器对试验数据进行分类,得到满意的分类结果。最大分类准确率达到89.29%,最大互信息为0.59bit。初步结果表明,Adaboost可以有效提高左手和右手运动意象任务的分类准确率,因此在脑机接口的心理任务分类中具有很大的潜力。
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引用次数: 9
Wavelet transform analyzing and real-time learning method for myoelectric signal in motion discrimination 运动识别中肌电信号的小波变换分析及实时学习方法
Liu Haihua, Chen Xinhao, Chen Yaguang
This paper discusses the applicability of the wavelet transform for analyzing EMG signal and discriminating motion classes. In previous many works, researchers have dealt with steady EMG and have proposed analyzing methods being suitable for the EMG, for example FFT and STFT. Therefore, it is difficult for the previous approaches to discriminate motions from the EMG in the different phases of muscle activity, i.e., pre-activity, in activity, post-activity phases, as well as the period of motion transition from one to another. In this paper, we introduce the wavelet transform using the Coiflet mother wavelet into our real-time EMG prosthetic hand controller for discriminating motions from steady and unsteady EMG. A preliminary experiment to discriminate three hand motions from four channels EMG in the initial pre-activity and in activity phase is carried out to show the effectiveness of the approach. However, future research effort is necessary to discriminate more motions much precisely.
讨论了小波变换在肌电信号分析和运动分类中的适用性。在之前的许多工作中,研究人员已经处理了稳定的肌电信号,并提出了适用于肌电信号的分析方法,如FFT和STFT。因此,以往的方法很难从肌电图中区分肌肉活动的不同阶段,即活动前、活动中、活动后阶段,以及运动从一个阶段到另一个阶段的过渡时期。本文利用Coiflet母小波将小波变换引入到我们的实时肌电假手控制器中,用于识别稳态和非稳态肌电运动。实验结果表明,该方法具有较好的识别手部运动的能力。然而,为了更精确地区分更多的运动,未来的研究工作是必要的。
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引用次数: 7
Nonlinear kinetics, fractals and chaos: applications to potassium single channel 非线性动力学,分形和混沌:钾单通道的应用
Tonghan Lan, Cheng Bo, Qi-ling Liu, Jiarui Lin
The kinetics of ion channels have been widely modeled as a Markov process. In these models it is assumed that the channel protein has a small number of discrete conformational states and kinetic rate constants connecting these states are constant. In this paper, voltage-dependent K/sup +/ channel current is recorded using cell-attached patch-clamp technique in rat dorsal root ganglion neurons. Due to various sources of noise, such as, seal leakage, electronic noise in the equipment, and shot noise in the channel. Firstly wavelet packet (WP) analysis is applied denoise, the error analysis shown that max error is 10.658fA, the result shown patch-clamp signals exist partially noise eliminated. Secondly Spectral analysis of ion channel current is studied, the result make known that spectrum is not flat spectrum, the data set from wavelet reconstruction shows considerable variability with a broad 1/f-like spectrum. Thirdly the phase space plot of x(t+/spl Delta/ t) versus x(t) is different for the random and the deterministic process, thus phase space analysis can be used to analyze time series to determine if it was generated by a random or a deterministics mechanism, the result is indicated that the gating kinetics of k/sup +/ channel in rat dorsal root ganglion neurons with nonlinear dynamics properties. Absolute values of C/sub a,b/ coefficients for different scales look similar, while resemblance index also resembles itself at difference scales. Thus, the voltage dependence of the gating of this ion channel exhibits nonlinear dynamics properties.
离子通道动力学已被广泛地建模为一个马尔可夫过程。在这些模型中,假设通道蛋白具有少量的离散构象状态,并且连接这些状态的动力学速率常数是恒定的。本文利用细胞贴附膜片钳技术,记录了大鼠背根神经节神经元的电压依赖性K/sup +/通道电流。由于各种噪声源,如密封泄漏、设备中的电子噪声、通道中的弹丸噪声等。首先对小波包(WP)分析进行去噪,误差分析表明最大误差为10.658fA,结果表明膜片钳信号存在部分噪声消除。其次,研究了离子通道电流的谱分析,结果表明,谱不是平坦谱,小波重构的数据集具有较大的变异性,具有较宽的1/f谱。第三,随机过程和确定性过程的x(t+/spl δ / t)与x(t)的相空间图不同,因此相空间分析可以用来分析时间序列,以确定它是由随机机制产生的还是由确定性机制产生的,结果表明大鼠背根神经节神经元k/sup +/通道的门控动力学具有非线性动力学特性。C/下标a、b/系数在不同尺度上的绝对值相似,而相似性指数在不同尺度上也相似。因此,该离子通道门控的电压依赖性表现出非线性动力学特性。
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引用次数: 0
A 16-site neural recording probe array and its circuit model simulation 一种16点神经记录探针阵列及其电路模型仿真
Lin Jianhui, Wu Xiaoming, Huang Pengsheng, Ren Tianling, Liu Litian
This paper introduces a simple MEMS (micro electromechanical system) process to fabricate a 16-site neural recording probe array and gives a detailed characterization of the neuron-electrode interface, based on the equivalent circuit approach. The impedance magnitude of the probes shows approximately a constant slope of f/sup -0.75/ from 100Hz up to 1MHz. The action potential can be simulated by the general-purpose circuit simulation program, such as HSPICE. The responses of the microelectrodes act as a function of several parameters, such as the sealing resistance and input resistance of the preamplifier. The responses are not sensitive to the changes of the microelectrode parameters. However, appreciable influence of the parasitic capacitance was obtained when the sealing resistance was large (e.g. 100M/spl Omega/).
本文介绍了一种简单的MEMS(微机电系统)工艺,用于制造16位神经记录探针阵列,并基于等效电路方法对神经元-电极界面进行了详细表征。从100Hz到1MHz,探头的阻抗大小显示出大约恒定的斜率f/sup -0.75/。动作电位可以通过通用电路仿真程序(如HSPICE)进行模拟。微电极的响应是几个参数的函数,如前置放大器的密封电阻和输入电阻。该响应对微电极参数的变化不敏感。当密封电阻较大(如100M/spl ω /)时,寄生电容对密封电阻的影响较为明显。
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引用次数: 2
Subretinal implantable artificial photoreceptor 视网膜下植入式人工感光器
Pei Weihua, Chen Hongda, Tang Jun, Lu Lin, Liu Jin-bin, Su Xiaohong, Wu Huijuan, Huo Xiaofeng, C. Jinghua, L. Xiaoxin, Li Kai
The present study reports a subretinal implant device which can imitate the function of photoreceptor cells. Photodiode (PD) arrays on the chip translate the incident light into current according to the intensity of light. With an electrode at the end of every photodiode, the PDs transfer the current to the remnant healthy visual cells such as bipolar cells and horizontal cells and then activate these cells. Biocompatible character of the materials and artificial photoreceptor itself were tested and the photoelectric characteristics of the chips in simulative condition were described and discussed.
本研究报道了一种可以模拟感光细胞功能的视网膜下植入装置。芯片上的光电二极管(PD)阵列根据光的强度将入射光转换成电流。在每个光电二极管的末端都有一个电极,pd将电流转移到剩余的健康视觉细胞,如双极细胞和水平细胞,然后激活这些细胞。测试了材料和人工光感受器本身的生物相容性,并对模拟条件下芯片的光电特性进行了描述和讨论。
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引用次数: 0
Recognition and analyses of EEG & ERP signals related to emotion: from the perspective of psychology 情绪相关EEG和ERP信号的识别与分析:基于心理学的视角
Yang Yuankui, Z. Jianzhong
Electroencephalography (EEG) is widely used to record activities of human brain in the area of psychology for many years. With the development of technology, neural basis of functional areas of emotion processing is revealed gradually. In order to extract the useful information of emotion from the background of EEG signals and noise, we propose to combine methods of psychology and the technology of signal processing such as pattern recognition, etc. In this paper, we first review the psychological methods and signal processing technology in the field of emotion research, and point out the junctions of these two approaches. Secondly, we introduce a method to evaluate emotion competence objectively, which involves the analyses of frequency fluctuations of EEG signals and frontal EEG asymmetry. Then, we take an example of event-related potentials (ERP) study about the face recognition task and the discrimination of sad/happy/neutral emotional facial expressions task. Finally, we indicate the present difficulties in this research area, and advance the possible solution to resolve these problems.
脑电图(EEG)在心理学领域被广泛用于记录人脑活动。随着技术的发展,情绪处理功能区的神经基础逐渐被揭示出来。为了从脑电信号和噪声的背景中提取有用的情绪信息,我们提出将心理学方法与模式识别等信号处理技术相结合。本文首先回顾了情绪研究领域的心理学方法和信号处理技术,并指出了这两种方法的联系。其次,介绍了一种客观评价情绪能力的方法,该方法包括分析脑电信号的频率波动和额叶脑电信号的不对称性。然后,我们以事件相关电位(ERP)在人脸识别任务和悲伤/快乐/中性面部表情识别任务中的应用为例进行了研究。最后,指出了该研究领域目前存在的困难,并提出了解决这些问题的可能方法。
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引用次数: 13
期刊
Proceedings. 2005 First International Conference on Neural Interface and Control, 2005.
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