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Electrical Stimulated Polyvinyl Alcohol-Borax-Graphene Hydrogel for Drug Releasing and Delivery 电刺激聚乙烯醇-硼砂-石墨烯水凝胶用于药物释放和递送
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0269
Jafar M. Batayneh
Polyvinyl Alcohol hydrogel has promising applications in numerous biomedical, biomaterial, and tissue engineering. However, it has poor conductive properties, restraining its development within huge fields such as bio-signals acquisition systems, thermal stability, and drug delivery. Adding Graphene as a nanofiller will produce PVA/Borax/Graphene nanocomposite hydrogel, which is an excellent procedure to significantly improve the conductive properties of PVA. The toxicity will not affect the nanocomposite while very well-dispersed graphene will significantly improve the thermal and conductivity stability of the nanocomposite. In this study, we investigated the performance of a newly prepared conductive hydrogel gel using the freezing/thawing method
聚乙烯醇水凝胶在生物医学、生物材料和组织工程等领域有着广阔的应用前景。然而,由于其导电性能较差,限制了其在生物信号采集系统、热稳定性和药物传递等巨大领域的发展。添加石墨烯作为纳米填料制备PVA/硼砂/石墨烯纳米复合水凝胶,是一种显著提高PVA导电性能的优良工艺。石墨烯的毒性不会影响纳米复合材料,而分散良好的石墨烯将显著提高纳米复合材料的导热稳定性。在本研究中,我们用冷冻/解冻法研究了新制备的导电水凝胶的性能
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引用次数: 0
Effect of Anions and Related Organic Compounds on the Kinetics of Thiocyanate Oxidation in a Solar-induced Oxidative System 阴离子及相关有机化合物对太阳诱导氧化系统中硫氰酸盐氧化动力学的影响
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0272
Agnia A. Batoeva
The effect of anions (hydrocarbonates, chlorides, sulfates) and organic compounds (xanthates) on the kinetics of thiocyanate oxidation in a photoinduced iron-persulfate system was studied using natural sunlight as a radiation source. It was found that the introduction of anions into the solution inhibits the degradation of thiocyanates. Hydrocarbonates have the maximum effect, so at a HCO–3 concentration of 1 mM, the processing time required for the complete destruction of thiocyanates increased from 6 to 15.7 minutes. At high concentrations of bicarbonates (≥5 mM), the oxidation efficiency of thiocyanates does not exceed 52 %. The adding of butyl xanthate into the solution has no significant effect on the photochemical oxidation of thiocyanates. In real water matrices (tap water and circulating water of the tailing dump of a gold mining plant), oxidative processes are significantly slowed down. In tap water, this effect is mainly due to the influence of hydrocarbonates, and in waste water, it is due to the multicomponent nature of the water matrix. The efficiency of wastewater treatment from thiocyanates was 100 %, for COD – 82 %, for dissolved organic carbon – 65 %. No cyanides were found after the treatment
以自然太阳光为辐射源,研究了阴离子(碳酸盐、氯化物、硫酸盐)和有机化合物(黄药)对过硫酸铁体系中硫氰酸盐氧化动力学的影响。结果表明,阴离子的引入抑制了硫氰酸酯的降解。碳酸盐的作用最大,因此在HCO-3浓度为1 mM时,硫氰酸酯完全破坏所需的处理时间从6分钟增加到15.7分钟。在高浓度碳酸氢盐(≥5 mM)下,硫氰酸酯的氧化效率不超过52%。在溶液中加入丁基黄药对硫氰酸酯的光化学氧化无显著影响。在真实的水基质中(自来水和金矿厂尾矿库的循环水),氧化过程明显减慢。在自来水中,这种影响主要是由于碳酸盐的影响,而在废水中,这是由于水基质的多组分性质。硫氰酸酯废水处理效率为100%,COD - 82%,溶解有机碳- 65%。处理后未发现氰化物
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引用次数: 0
Preparation of a New Drug Based on Cis-Dichlorodiamminplatin(II), Arabinogalactan and Aptamer AS‑42 and Study of its Biological Activity 顺式二氯双明铂(II)、阿拉伯半乳聚糖及适配体AS‑42合成新药及其生物活性研究
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0273
A. K. Starkov
A new drug based on a complex of cis-dichlorodiamminplatin(II) with arabinogalactan and aptamer AS‑42 was obtained. The drug is characterized by the methods of XRD, thermogravimetry. IR spectroscopy. Its biological activity has been studied
以顺式二氯双明铂(II)与阿拉伯半乳聚糖和适体AS‑42配合物为基础,制备了一种新型药物。用XRD、热重法对该药物进行了表征。红外光谱。对其生物活性进行了研究
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引用次数: 0
Hydrodynamically Activated Sawdust of Common Pine Pinus sylvestris L.-substrate for Cultivation of the Strain Gl4–16A Ganoderma lucidum 水动力活化普通松木屑——培养菌株Gl4-16A灵芝的基质
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0274
V. S. Fedorov
The results of a study on the use of sawdust of common pine Pinus sylvestris L. with their preliminary activation in a cavitation water-impact dispersant for 25 minutes as a substrate for cultivating the Gl4–16A strain of Ganoderma lucidum are presented. It was found that the Gl4–16A strain of Ganoderma lucidum colonizes the substrate more efficiently with the introduction of (NH4)2SO4 and Na2HPO4 salts into its composition. At the same time, the average growth rate of basidiomycete on the substrate without the introduction of salts was 1.39±0.53 mm/day, and on the substrate with nitrogen salts – 3.22±0.48 mm/day, and complete fouling of the substrate occurred on day 13. It was found that during the cultivation of the Gl4–16A strain of Ganoderma lucidum on a substrate with nitrogen salts, the content of extractive substances in it increases from 4.37 % to 6.32 %, where more than 65 % is accounted for by substances extracted with water. There is a decrease in the content of difficult-to-hydrolyze polysaccharides by 13.3 %, and an increase in the non-hydrolyzable part by 2.4 %, which is 6.8 % per organic mass. The content of easily hydrolyzable polysaccharides (LGA) decreases by 2.4 %, but this change is not significant in terms of organic mass and the share of LGA both before and after bioconversion is about 15.7 %. The obtained data can expand the field of use of sawdust, which is a promising direction, both in the chemical and pharmaceutical industries
本文报道了以普通松木木屑为基质培养灵芝Gl4-16A菌株的研究结果,木屑在空化水冲击分散剂中初步活化25分钟。研究发现,在灵芝Gl4-16A菌株的组成中引入(NH4)2SO4和Na2HPO4盐后,菌株在底物上的定殖效率更高。同时,担子菌在未添加盐的培养基上的平均生长速率为1.39±0.53 mm/d,在添加了氮盐的培养基上的平均生长速率为3.22±0.48 mm/d,并在第13天发生基质完全污染。结果表明,在含氮培养基上培养灵芝Gl4-16A菌株,其萃取物含量由4.37%增加到6.32%,其中水萃取物占65%以上。难水解多糖的含量减少了13.3%,而不可水解部分的含量增加了2.4%,即每有机质量的6.8%。易水解多糖(LGA)的含量下降了2.4%,但在有机质量方面变化不显著,生物转化前后LGA的比例均为15.7%左右。所获得的数据可以扩大木屑的使用领域,这是一个有前途的方向,无论是在化学工业还是制药工业
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引用次数: 0
Synthesis and Properties of Polymers Based on Styrene and α-angelicalactone 苯乙烯- α-天使内酯聚合物的合成及性能研究
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0266
K. L. Kaigorodov
Polyangelicalactone-graft-polystyrene copolymers were obtained through cationic polymerization. Increasing the portion of styrene units in the copolymers improves the strength properties and increases fragility. Increasing the polyangelicalactone(PAL) content in the copolymers increases the elasticity of the materials obtained. The obtained copolymers are greatly a composition of PAL and polystyrene (PS)with a small content of bonds of styrene-units of 4-alkoxypent‑3-enoic acid.Low α-angelicalactone(AL) content in styrene copolymers improves the oxidative stability of the copolymers. The resulting PAL‑graft-PScopolymers have physical and mechanical properties corresponding to the requirements for general-purpose PS
采用阳离子聚合法制备了聚angelicalacton -接枝聚苯乙烯共聚物。增加共聚物中苯乙烯单元的比例可以提高共聚物的强度性能并增加其脆性。增加共聚物中聚angelicalactone(PAL)的含量可以提高所制材料的弹性。所制得的共聚物主要由聚苯乙烯(PS)和聚苯乙烯(PAL)组成,其中苯乙烯键(4-烷氧基- 3-烯酸单元)的含量很少。苯乙烯共聚物中α-angelicalactone(AL)的低含量提高了共聚物的氧化稳定性。所得到的聚丙烯酸酯接枝聚合物具有符合通用聚丙烯酸酯要求的物理和机械性能
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引用次数: 0
Synthesis and Sulfation with Sulfamic Acid of Aerogels Based on Birch-Wood and Cotton Celluloses 桦木和棉纤维素气凝胶的合成及氨基磺酸磺化
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0271
B. Kuznetsov
Firstly, the structure and properties of cellulose aerogels produced from birch-wood and cottoncellulose and of, and products of their sulfation with a non-toxic sulfamic acid-urea complex in an environmentally safe solvent – a mixture of polyethylene glycol and sodium hydroxide are compared. Aerogels based on birch and cotton celluloses have similar values of apparent density (0,071–0,078 г/см3) and porosity (near 95 %). The products of sulfating of cellulose aerogels, in contrast to the originalbirch and cotton celluloses, are completely soluble in water. Their yield and degree of substitution are higher when using birch cellulose aerogel. By drying the dissolved products of sulfating of cellulose aerogels, smooth and transparent films were produced. The structure and morphology of the obtained aerogels and films were established by metods of scanning electron microscopy and atomic force microscopy. Birch cellulose aerogel (BCA) has a reticular microfibrillated porous structure, and cotton cellulose aerogel (CCA) has a spongy structure in which more cavities and cracks are observed than in the case of CCA. The surface of the film of sulfated BCA is formed by particles with a length 100–200 nm and width of 50–70 nm, and the films of sulfated CCA is formed by spherical particles with a diameter of 70–100 nm. The developed methods for obtaining sulfated cellulose films can be used in medicine to oreate anticoagulant coatings
首先,比较了由桦木和棉纤维素制成的纤维素气凝胶的结构和性能,以及它们在环境安全的溶剂-聚乙二醇和氢氧化钠的混合物中用无毒的氨基磺酸-尿素络合物磺化的产物。基于桦木和棉花纤维素的气凝胶具有相似的表观密度值(0,071-0,078 /см3)和孔隙度(接近95%)。硫酸盐酸化的纤维素气凝胶的产品,与原来的桦树和棉花纤维素相反,是完全可溶于水的。使用桦木纤维素气凝胶时,它们的产率和取代度更高。通过对纤维素气凝胶硫酸酸化溶解产物进行干燥,得到光滑透明的薄膜。通过扫描电镜和原子力显微镜对制备的气凝胶和膜的结构和形貌进行了表征。桦木纤维素气凝胶(BCA)具有网状微纤化多孔结构,棉纤维素气凝胶(CCA)具有海绵状结构,其中比CCA观察到更多的空洞和裂缝。硫酸酸化BCA膜表面由长度为100-200 nm、宽度为50-70 nm的颗粒组成,硫酸酸化CCA膜由直径为70-100 nm的球形颗粒组成。所开发的硫酸盐纤维素膜的制备方法可用于医学上制备抗凝涂层
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引用次数: 3
High-pressure Helium as a Template for the Formation of a Microporous Silica Structure 高压氦作为形成微孔二氧化硅结构的模板
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0278
Sergey V. Kukhtetskiy
The modeling of various modes of formation of microporous silica using high-pressure helium was carried out by the methods of molecular dynamics. It is shown that by controlling the helium pressure in the process of quenching the silica melt, the structure of the obtained glasses can be changed continuously and within wide limits. The density of the obtained glasses varies in the range from 2.2 to 1.5 g / cm3 and the Ostwald solubility coefficients for helium and neon are more than an order of magnitude
采用分子动力学方法对高压氦作用下二氧化硅微孔的各种形成模式进行了建模。结果表明,在石英熔体淬火过程中控制氦气压力,可以在较宽的范围内连续改变玻璃的结构。所得玻璃的密度在2.2 ~ 1.5 g / cm3之间变化,氦和氖的奥斯特瓦尔德溶解度系数大于一个数量级
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引用次数: 1
Synthesis, Crystal Structure and Thermodynamic Properties of Apatite-like Lead Gadolinium Vanadato-germanates 类磷灰石型铅钆钒锗酸盐的合成、晶体结构和热力学性质
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0277
L. T. Denisova
The Pb10-xGdx(GeO4)2+x(VO4)4-x (x = 0.5, 1.0) apatites were synthesized by the solid-phase synthesis by roasting stoichiometric mixtures of PbO, Gd2O3, GeO2, and V2O5 in air at temperatures of 773–1073 K. Their crystal structure was determined using X‑ray diffraction analysis. The high-temperature heat capacity (350–1000 K) was measured by differential scanning calorimetry. The experimental data Cp = f (T) were used to calculate the thermodynamic properties of apatites
用PbO、Gd2O3、GeO2和V2O5的化学测量混合物在773 ~ 1073 K的空气中焙烧,采用固相法合成Pb10-xGdx(GeO4)2+x(VO4)4-x (x = 0.5, 1.0)磷灰石。用X射线衍射分析确定了它们的晶体结构。采用差示扫描量热法测定高温热容(350 ~ 1000 K)。利用实验数据Cp = f (T)计算磷灰石的热力学性质
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引用次数: 0
Study of the Effect of Silica Filler Silica 1165 on the Properties of Rubber for Rail Fastening Gaskets 二氧化硅填料二氧化硅1165对钢轨紧固垫片橡胶性能影响的研究
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0276
E. N. Egorov
The effect of silica filler Silica 1165 instead of kaolin and carbon black N220 on the plasto-elastic, rheometric, physical-mechanical, operational and dynamic properties of rubber based on general-purpose caoutchoucs was investigated in order to develop effective noise and vibration-absorbing rubber gaskets of rail fasteners for railway tracks. It has been established that the developed rubber with a sulfur vulcanizing system based on SKMS-30ARK, SKI-3 и SKD caoutchoucs with Silica 1165 additives has improved plasto-elastic and rheometric indicators, satisfactory physical and mechanical properties, is characterized by an increase in the vibration-absorbing properties of rubber, which is the determining factor for under-rail pads
为了研制有效的铁路轨道扣件吸声减振橡胶垫片,研究了用硅填料二氧化硅1165代替高岭土和碳黑N220对通用型橡胶的塑性弹性、流变学、物理力学、操作性能和动力学性能的影响。结果表明,以SKMS-30ARK、SKI-3、SKD为基础,添加二氧化硅1165的硫硫化体系橡胶的弹弹性和流变学指标得到改善,物理力学性能令人满意,橡胶的吸振性能得到提高,这是轨道垫的决定性因素
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引用次数: 0
Utilization of Poplar Leaves (Populus balsamifera L.) by Bioconversion 杨树叶片的生物转化利用
IF 0.4 Q4 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-03-01 DOI: 10.17516/1998-2836-0275
O. O. Mamaeva
The results on the possibility of utilization of post-extractionation residues of green leaves of balsamic poplar (Populus balsamifera L.) by xylotrophic basidiomycetes Fomitopsis pinicola (strain Fp5–15) are presented. It was found that the most favorable for the growth and development of fungi is the residue after the extraction of alcohol-soluble substances. High growth parameters of fungi are observed on this substrate, such as the growth rate, which is 3.9 mm/day and the growth coefficient is 15.6. During the biocoversion of Fp5–15, F. pinicola utilizes up to 30 % of extractive substances and polysaccharides. At the same time, the utilization of easily hydrolyzable polysaccharides is 24 %, difficult-to-hydrolyze‑30 %. Also, in the process of destruction, up to 12 % of lignin substances are disposed of. The decrease in the mass of the substrate after the bioconversion process is 14 %. It is noted that in the process of bioconversion, the substrate is enriched with protein (up to 24 %)
本文研究了木营养担子菌Fp5-15对香杨绿叶残渣利用的可能性。结果表明,醇溶性物质提取后的残渣最有利于真菌的生长发育。在该基质上观察到真菌的高生长参数,如生长速率为3.9 mm/d,生长系数为15.6。在Fp5-15的生物转化过程中,F. pinicola利用高达30%的萃取物质和多糖。同时易水解多糖的利用率为24%,难水解多糖的利用率为30%。此外,在破坏过程中,高达12%的木质素物质被处理掉。生物转化过程后,底物的质量下降了14%。值得注意的是,在生物转化过程中,底物富含蛋白质(高达24%)。
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引用次数: 0
期刊
Journal of Siberian Federal University. Chemistry
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