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Comparing the Effectiveness of Open, Laparoscopic, and Robotic Gastrectomy in the United States: A Retrospective Analysis of Perioperative, Oncologic, and Survival Outcomes 比较美国开腹、腹腔镜和机器人胃切除术的效果:围手术期、肿瘤学和生存结果的回顾性分析。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-16 DOI: 10.1016/j.jss.2024.10.014
Andrei Gurau MD, MHS, MS , Olivia Monton MD, ScM , Jonathan B. Greer MD , Fabian M. Johnston MD, MHS
<div><h3>Introduction</h3><div>Minimally invasive surgery (MIS) is increasingly used in the surgical management of gastric cancer; however, its adoption lags that of other cancers. Most randomized controlled trials comparing MIS to open gastrectomy have been conducted in Asia, with limited data from the United States. This study aimed to compare perioperative, oncologic, and survival outcomes between open, laparoscopic, and robotic gastrectomy in a large US cohort.</div></div><div><h3>Methods</h3><div>Using the National Cancer Database, we identified patients with gastric adenocarcinoma who underwent open, laparoscopic, or robotic gastrectomy between 2010 and 2020. Multivariate regression models were used to examine the association between surgical approach and various outcomes, including 30-d readmission, length of stay (LOS), surgical margin status, lymph node yield, 30- and 90-d mortality, and overall survival (OS). The interaction between surgical approach and tumor location (distal versus proximal or gastroesophageal junction [GEJ]) was also assessed.</div></div><div><h3>Results</h3><div>Of the 34,937 included patients, 64.8% underwent open gastrectomy, 25.7% underwent laparoscopic surgery, and 9.5% underwent robotic surgery. MIS was associated with lower odds of 30-d readmission (laparoscopic: odds ratio [OR] 0.78, 95% confidence interval [CI] 0.67-0.89; robotic: OR 0.75, 95% CI 0.60-0.92), positive margins (laparoscopic: OR 0.83, 95% CI 0.74-0.93; robotic: OR 0.75, 95% CI 0.62-0.90), 30-d mortality (laparoscopic: OR 0.69, 95% CI 0.55-0.85; robotic: OR 0.66, 95% CI 0.44-0.95), and 90-d mortality (laparoscopic: OR 0.74, 95% CI 0.63-0.87; robotic: OR 0.63, 95% CI 0.47-0.84), as well as improved OS (laparoscopic: hazard ratio 0.83, 95% CI 0.79-0.87; robotic: hazard ratio 0.76, 95% CI 0.69-0.83) compared to open surgery. Considering the interaction of approach with tumor location, for proximal/GEJ tumors, the associated outcome improvements with MIS were attenuated. We observe that the odds for 30-d readmission, 90-d mortality, and OS are similar to those for open operations. However, regardless of tumor location, robotic gastrectomy was associated with decreased LOS and yielded a higher lymph node count than laparoscopic or open approaches.</div></div><div><h3>Conclusions</h3><div>In this large US cohort, MIS gastrectomy was associated with improved perioperative, oncologic, and survival outcomes compared to open surgery for distal gastric cancers. However, the associated benefits of MIS were attenuated for proximal/GEJ tumors, with higher odds of readmission, mortality, and worse OS. Notably, robotic gastrectomy was associated with superior lymph node yield and LOS compared to laparoscopic and open approaches, even for proximal/GEJ tumors. These findings underscore the need for further research, especially randomized controlled trials conducted in Western populations, to definitively determine the efficacy of MIS for distal and proximal/GEJ t
导言:微创手术(MIS)越来越多地用于胃癌的外科治疗,但其应用却落后于其他癌症。大多数比较微创手术和开腹胃切除术的随机对照试验都是在亚洲进行的,来自美国的数据有限。本研究旨在比较美国大样本中开腹胃切除术、腹腔镜胃切除术和机器人胃切除术的围手术期、肿瘤学和生存结果:我们利用美国国家癌症数据库,确定了2010年至2020年间接受开腹、腹腔镜或机器人胃切除术的胃腺癌患者。我们使用多变量回归模型研究了手术方式与各种结果之间的关系,包括 30 天再入院率、住院时间(LOS)、手术边缘状态、淋巴结转移率、30 天和 90 天死亡率以及总生存率(OS)。此外,还评估了手术方法与肿瘤位置(远端与近端或胃食管交界处[GEJ])之间的相互作用:结果:在纳入的 34,937 例患者中,64.8% 接受了开腹胃切除术,25.7% 接受了腹腔镜手术,9.5% 接受了机器人手术。MIS 与较低的 30 天再入院几率相关(腹腔镜:几率比 [OR] 0.78,95% 置信区间 [CI]0.67-0.89;机器人:几率比 [OR] 0.75,95% 置信区间 [CI]0.67-0.89):OR为0.75,95% CI为0.60-0.92)、边缘阳性(腹腔镜:OR为0.83,95% CI为0.74-0.93;机器人:OR为0.75,95% CI为0.62-0.90)、30天死亡率(腹腔镜:OR为0.69,95% CI为0.55-0.85;机器人:OR为0.66,95% CI为0.44-0.95)和90天死亡率(腹腔镜:OR为0.69,95% CI为0.55-0.85;机器人:OR为0.66,95% CI为0.44-0.95)均较低。95)和90天死亡率(腹腔镜:OR 0.74,95% CI 0.63-0.87;机器人:OR 0.63,95% CI 0.47-0.84),与开腹手术相比,OS(腹腔镜:危险比0.83,95% CI 0.79-0.87;机器人:危险比0.76,95% CI 0.69-0.83)也有所改善。考虑到手术方式与肿瘤位置的交互作用,对于近端/GEJ肿瘤,MIS手术的相关预后改善有所减弱。我们观察到,30 天后再入院、90 天后死亡率和 OS 的几率与开放手术相似。然而,与腹腔镜或开腹手术相比,无论肿瘤位置如何,机器人胃切除术都能缩短住院时间并获得更高的淋巴结计数:结论:在这一大型美国队列中,与开腹手术相比,MIS胃切除术可改善远端胃癌的围手术期、肿瘤学和生存率。然而,对于近端/GEJ肿瘤,MIS的相关益处有所减弱,再入院几率更高、死亡率更高、OS更差。值得注意的是,与腹腔镜和开腹方法相比,机器人胃切除术的淋巴结产量和LOS都更高,即使是近端/GEJ肿瘤也是如此。这些发现强调了进一步研究的必要性,尤其是在西方人群中开展随机对照试验,以明确确定 MIS 对远端和近端/GEJ 肿瘤的疗效,并指导胃腺癌的手术决策。
{"title":"Comparing the Effectiveness of Open, Laparoscopic, and Robotic Gastrectomy in the United States: A Retrospective Analysis of Perioperative, Oncologic, and Survival Outcomes","authors":"Andrei Gurau MD, MHS, MS ,&nbsp;Olivia Monton MD, ScM ,&nbsp;Jonathan B. Greer MD ,&nbsp;Fabian M. Johnston MD, MHS","doi":"10.1016/j.jss.2024.10.014","DOIUrl":"10.1016/j.jss.2024.10.014","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Minimally invasive surgery (MIS) is increasingly used in the surgical management of gastric cancer; however, its adoption lags that of other cancers. Most randomized controlled trials comparing MIS to open gastrectomy have been conducted in Asia, with limited data from the United States. This study aimed to compare perioperative, oncologic, and survival outcomes between open, laparoscopic, and robotic gastrectomy in a large US cohort.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Using the National Cancer Database, we identified patients with gastric adenocarcinoma who underwent open, laparoscopic, or robotic gastrectomy between 2010 and 2020. Multivariate regression models were used to examine the association between surgical approach and various outcomes, including 30-d readmission, length of stay (LOS), surgical margin status, lymph node yield, 30- and 90-d mortality, and overall survival (OS). The interaction between surgical approach and tumor location (distal versus proximal or gastroesophageal junction [GEJ]) was also assessed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Of the 34,937 included patients, 64.8% underwent open gastrectomy, 25.7% underwent laparoscopic surgery, and 9.5% underwent robotic surgery. MIS was associated with lower odds of 30-d readmission (laparoscopic: odds ratio [OR] 0.78, 95% confidence interval [CI] 0.67-0.89; robotic: OR 0.75, 95% CI 0.60-0.92), positive margins (laparoscopic: OR 0.83, 95% CI 0.74-0.93; robotic: OR 0.75, 95% CI 0.62-0.90), 30-d mortality (laparoscopic: OR 0.69, 95% CI 0.55-0.85; robotic: OR 0.66, 95% CI 0.44-0.95), and 90-d mortality (laparoscopic: OR 0.74, 95% CI 0.63-0.87; robotic: OR 0.63, 95% CI 0.47-0.84), as well as improved OS (laparoscopic: hazard ratio 0.83, 95% CI 0.79-0.87; robotic: hazard ratio 0.76, 95% CI 0.69-0.83) compared to open surgery. Considering the interaction of approach with tumor location, for proximal/GEJ tumors, the associated outcome improvements with MIS were attenuated. We observe that the odds for 30-d readmission, 90-d mortality, and OS are similar to those for open operations. However, regardless of tumor location, robotic gastrectomy was associated with decreased LOS and yielded a higher lymph node count than laparoscopic or open approaches.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;In this large US cohort, MIS gastrectomy was associated with improved perioperative, oncologic, and survival outcomes compared to open surgery for distal gastric cancers. However, the associated benefits of MIS were attenuated for proximal/GEJ tumors, with higher odds of readmission, mortality, and worse OS. Notably, robotic gastrectomy was associated with superior lymph node yield and LOS compared to laparoscopic and open approaches, even for proximal/GEJ tumors. These findings underscore the need for further research, especially randomized controlled trials conducted in Western populations, to definitively determine the efficacy of MIS for distal and proximal/GEJ t","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"304 ","pages":"Pages 196-206"},"PeriodicalIF":1.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enteral and Parenteral Nutrition Timing in eICU Collaborative Research Database by Race: A Retrospective Observational Study 按种族分列的 eICU 协作研究数据库中肠内和肠外营养时间:一项回顾性观察研究。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-16 DOI: 10.1016/j.jss.2024.10.021
An-Kwok Ian Wong MD, PhD , Paul E. Wischmeyer MD , Haesung Lee DO , Laura Gorenshtein DO , Trevor Sytsma BS , Sicheng Hao MS , Chuan Hong PhD , Nrupen A. Bhavsar PhD , Ricardo Henao PhD , Matt Maciejewski PhD , Michael Pencina PhD , Christopher E. Cox MD, MPH , Joseph Fernandez-Moure MD, MS , Suresh Agarwal MD , Krista Haines DO, MA

Introduction

Racial and ethnic disparities in malnutrition are well-known, but it is unknown if there are disparities in early nutrition delivery for intensive care unit (ICU) patients, which is associated with better outcomes. We investigated the timing of enteral nutrition (EN) and parenteral nutrition (PN) initiation in the ICU, examining for racial differences.

Methods

Using the eICU-Collaborative Research Database (eICU-CRD) from 2014 to 2015, we analyzed patients eligible for EN and PN from 208 hospitals. EN and PN delivery was captured through intake/output entries. Exclusions included pre-existing EN/PN and short (<4 d) mechanical ventilation. Severity-of-illness was assessed using the sequential organ failure assessment (SOFA) score. Self-identified race was defined as the primary exposure, and Cox proportional hazards models were used to examine the association between race and time to EN and PN initiation, adjusting for patient, ICU, and hospital characteristics.

Results

Of 1914 patients from 14 hospitals with EN data (5.3% Black, 42.4% female, median age 65 y), 888 received EN. Among Black and White patients, the median [Q1, Q3] time from mechanical ventilation to EN was 1.5 [1.0, 2.8] d. Race was not associated with time until EN initiation (hazard ratio = 0.961, 95% confidence interval 0.693, 1.333). Rather, other variables including sex, SOFA score, hospital characteristics and ICU unit type appeared to account for variation in EN initiation. Among 31,551 patients from 59 hospitals with PN data (11.3% Black, 45.1% female, median age 67 y), 1140 received PN, with a median [Q1, Q3] time to PN initiation of 7.4 [4.2, 12.4] d amongst Black and White patients. Race was not associated with time until PN initiation (hazard ratio = 1.095, 95% confidence interval = 0.901, 1.331). Instead, sex, body mass index, SOFA score, hospital characteristics and ICU unit type appeared to account for variation in PN initiation.

Conclusions

Disparities in EN and PN delivery in the eICU-CRD dataset from 2014 to 2015 were not associated with race, but rather with sex, body mass index, SOFA, hospital characteristics and ICU unit type. Further investigations using more current data are needed.
简介:众所周知,营养不良存在种族和民族差异,但重症监护室(ICU)患者的早期营养提供是否存在差异尚不清楚,而早期营养提供与更好的预后相关。我们调查了重症监护病房开始肠内营养(EN)和肠外营养(PN)的时间,并研究了种族差异:我们使用 2014 年至 2015 年的 eICU 合作研究数据库(eICU-CRD),分析了 208 家医院符合 EN 和 PN 条件的患者。EN和PN的交付是通过入院/出院条目记录的。不包括已存在的EN/PN和短时间(结果:在 14 家医院的 1914 名有 EN 数据的患者(5.3% 为黑人,42.4% 为女性,中位年龄为 65 岁)中,有 888 人接受了 EN。在黑人和白人患者中,从机械通气到 EN 的中位时间 [Q1, Q3] 为 1.5 [1.0, 2.8] d。相反,包括性别、SOFA评分、医院特征和ICU病房类型在内的其他变量似乎是启动EN的原因。在有 PN 数据的 59 家医院的 31,551 名患者中(11.3% 为黑人,45.1% 为女性,中位年龄为 67 岁),有 1140 名患者接受了 PN,黑人和白人患者的 PN 启动时间中位数 [Q1, Q3] 为 7.4 [4.2, 12.4] d。种族与开始 PN 的时间无关(危险比 = 1.095,95% 置信区间 = 0.901,1.331)。相反,性别、体重指数、SOFA评分、医院特征和ICU病房类型似乎是启动PN的原因:2014年至2015年eICU-CRD数据集中EN和PN分娩的差异与种族无关,而是与性别、体重指数、SOFA、医院特征和ICU病房类型有关。需要使用更多最新数据进行进一步调查。
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引用次数: 0
Open or Closed? Management of Skin Incisions After Emergency General Surgery Laparotomies 开腹还是闭腹?普外科急诊腹腔手术后皮肤切口的处理。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-16 DOI: 10.1016/j.jss.2024.10.026
Shruthi Srinivas MD, Julia R. Coleman MD MPH, Holly Baselice MPH, Sara Scarlet MD MPH, Brett M. Tracy MD

Introduction

We sought to determine if there was a relationship between skin management and surgical site infections (SSIs) among patients undergoing a laparotomy for emergency general surgery (EGS). We hypothesize that skin closure technique is not associated with SSI.

Methods

We performed a retrospective review of adult patients (>18 y) who underwent an exploratory laparotomy for EGS conditions within 6 h of surgical consultation from 2015 to 2019. Patients whose fascia was not closed during the index operation were excluded. Patients were divided into groups: open skin (OS) and closed skin (CS). OS included negative pressure wound therapy or wet-to-dry gauze; CS included closure with staples or sutures. Our primary outcome was the rate of SSI.

Results

The cohort comprised 388 patients: 42.3% OS (n = 164) and 57.7% CS (n = 224). The OS group had greater rates of systemic inflammatory response syndrome [SIRS] (54.9% versus 27.7%, P < 0.0001), hollow viscus perforation [HVP] (71.3% versus 20.5%, P < 0.0001), and peritoneal drains (51.2% versus 17.9%, P < 0.0001). Rates of OS management increased as wound class severity increased (0% [I] versus 12.2% [II] versus 15.9% [III] versus 72% [IV], P < 0.0001). The SSI rate for the cohort was 3.6% (n = 14); there was no difference in SSI rates (2.7% versus 4.9%, P = 0.3) between the CS or OS groups. Median length of stay was longer for the OS group (10 d versus 6.5 d, P < 0.0001). Independent predictors of OS management were SIRS (adjusted odds ratio [aOR] 1.72, 95% confidence interval [CI] 1.01-2.93, P = 0.04), HVP (aOR 2.03, 95% CI 1.09-3.8, P = 0.03), and class III/IV wounds (aOR 8.65, 95% CI 4.43-16.89, P < 0.0001).

Conclusions

OS management occurs more often in patients with SIRS, HVP, and dirty wounds after EGS laparotomies. However, we found no difference in SSI between groups, suggesting that skin closure can be considered in contaminated or dirty wounds.
简介:我们试图确定急诊普外科(EGS)开腹手术患者的皮肤管理与手术部位感染(SSI)之间是否存在关系。我们假设皮肤闭合技术与 SSI 无关:我们对 2015 年至 2019 年期间因 EGS 病症在手术会诊后 6 小时内接受探查性开腹手术的成年患者(大于 18 岁)进行了回顾性研究。排除了在索引手术中筋膜未闭合的患者。患者分为两组:开放皮肤组(OS)和封闭皮肤组(CS)。OS包括负压伤口治疗或湿到干的纱布;CS包括用订书机或缝线缝合。我们的主要结果是 SSI 发生率:结果:组群包括 388 名患者:42.3%为OS组(164人),57.7%为CS组(224人)。OS组的全身炎症反应综合征[SIRS]发生率更高(54.9%对27.7%,P 结论:OS组的全身炎症反应综合征[SIRS]发生率更高:在 EGS 开腹手术后出现 SIRS、HVP 和伤口脏污的患者中,OS 处理更为常见。然而,我们发现不同组间的 SSI 并无差异,这表明对于污染或不洁伤口可考虑进行皮肤缝合。
{"title":"Open or Closed? Management of Skin Incisions After Emergency General Surgery Laparotomies","authors":"Shruthi Srinivas MD,&nbsp;Julia R. Coleman MD MPH,&nbsp;Holly Baselice MPH,&nbsp;Sara Scarlet MD MPH,&nbsp;Brett M. Tracy MD","doi":"10.1016/j.jss.2024.10.026","DOIUrl":"10.1016/j.jss.2024.10.026","url":null,"abstract":"<div><h3>Introduction</h3><div>We sought to determine if there was a relationship between skin management and surgical site infections (SSIs) among patients undergoing a laparotomy for emergency general surgery (EGS). We hypothesize that skin closure technique is not associated with SSI.</div></div><div><h3>Methods</h3><div>We performed a retrospective review of adult patients (&gt;18 y) who underwent an exploratory laparotomy for EGS conditions within 6 h of surgical consultation from 2015 to 2019. Patients whose fascia was not closed during the index operation were excluded. Patients were divided into groups: open skin (OS) and closed skin (CS). OS included negative pressure wound therapy or wet-to-dry gauze; CS included closure with staples or sutures. Our primary outcome was the rate of SSI.</div></div><div><h3>Results</h3><div>The cohort comprised 388 patients: 42.3% OS (<em>n</em> = 164) and 57.7% CS (<em>n</em> = 224). The OS group had greater rates of systemic inflammatory response syndrome [SIRS] (54.9% <em>versus</em> 27.7%, <em>P</em> &lt; 0.0001), hollow viscus perforation [HVP] (71.3% <em>versus</em> 20.5%, <em>P</em> &lt; 0.0001), and peritoneal drains (51.2% <em>versus</em> 17.9%, <em>P</em> &lt; 0.0001). Rates of OS management increased as wound class severity increased (0% [I] <em>versus</em> 12.2% [II] <em>versus</em> 15.9% [III] <em>versus</em> 72% [IV], <em>P</em> &lt; 0.0001). The SSI rate for the cohort was 3.6% (<em>n</em> = 14); there was no difference in SSI rates (2.7% <em>versus</em> 4.9%, <em>P</em> = 0.3) between the CS or OS groups. Median length of stay was longer for the OS group (10 d <em>versus</em> 6.5 d, <em>P</em> &lt; 0.0001). Independent predictors of OS management were SIRS (adjusted odds ratio [aOR] 1.72, 95% confidence interval [CI] 1.01-2.93, <em>P</em> = 0.04), HVP (aOR 2.03, 95% CI 1.09-3.8, <em>P</em> = 0.03), and class III/IV wounds (aOR 8.65, 95% CI 4.43-16.89, <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>OS management occurs more often in patients with SIRS, HVP, and dirty wounds after EGS laparotomies. However, we found no difference in SSI between groups, suggesting that skin closure can be considered in contaminated or dirty wounds.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"304 ","pages":"Pages 190-195"},"PeriodicalIF":1.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Equivalent Pain and Opioid Use Between Transabdominal and Retroperitoneal Adrenalectomy 经腹肾上腺切除术和腹膜后肾上腺切除术的疼痛和阿片类药物使用量相当。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-15 DOI: 10.1016/j.jss.2024.10.009
Lauren Haskins DO, MBA , Nicole Tobin MD , Elle Reineman , Rebecca Sippel MD , David Schneider MD , Kristin Long MD, MPH , Dawn Elfenbein MD , Courtney Balentine MD , Alexander Chiu MD, MPH

Introduction

Laparoscopic transabdominal adrenalectomy (LTA) and posterior retroperitoneoscopic adrenalectomy (PRA) are safe, effective surgical approaches. A direct comparison of postoperative pain and narcotic use is needed.

Methods

Adults who had laparoscopic adrenalectomy at a tertiary institution from 2015 to 2021 were identified from a surgical database. Evaluated key outcomes included opioid use and patient-reported pain during the perioperative period, which were analyzed by surgical approach and compared using multivariate linear regression. Additional data on pain postdischarge, prescription refills, length of stay, and 30-d readmission were also collected.

Results

Eighty-eight (69.3%) surgeries were LTA and 39 (30.7%) were PRA. The studied patient population was 58% female and had an average age of 54 (standard deviation 13). Adrenal tumors were 75% functional and 3.4 cm on average (standard deviation 2.6). Postoperative pain scores at rest (4.4 LTA versus 4.5 PRA, P = 0.87) and activity (4.7 LTA versus 5.6 PRA, P = 0.08) did not reach statistical significance. Patients undergoing LTA used a median of 110.3 morphine milligram equivalents (interquartile range 70.1-144.5) of opioids during their hospital stay compared to 91.0 (interquartile range 59.1-133.3) for PRA (P = 0.16). Linear regression demonstrated no significant difference in postoperative opioid use between approaches (−9.3 morphine milligram equivalents [95% confidence interval −40.7 to 22.1]).

Conclusions

Our analysis found no significant advantage of PRA over LTA in terms of postoperative pain or opioid use, contrary to earlier findings by Barczyński et al., who reported lower postoperative pain with PRA. Both approaches show similar clinical outcomes, and the choice between them should be based on individual patient factors rather than differences in patient-reported pain and opioid usage.
简介:腹腔镜经腹肾上腺切除术(LTA)和后腹膜后肾上腺切除术(PRA)是安全、有效的手术方法。需要对术后疼痛和麻醉剂使用情况进行直接比较:方法:从手术数据库中筛选出 2015 年至 2021 年期间在一家三级医院接受腹腔镜肾上腺切除术的成年人。评估的主要结果包括围手术期阿片类药物的使用情况和患者报告的疼痛情况,这些结果按手术方式进行分析,并使用多变量线性回归进行比较。此外,还收集了出院后疼痛、处方续订、住院时间和 30 天再入院的其他数据:88例(69.3%)手术为LTA,39例(30.7%)为PRA。研究对象中58%为女性,平均年龄54岁(标准偏差13)。功能性肾上腺肿瘤占 75%,平均 3.4 厘米(标准差 2.6)。术后休息时(4.4 LTA 对 4.5 PRA,P = 0.87)和活动时(4.7 LTA 对 5.6 PRA,P = 0.08)的疼痛评分没有统计学意义。接受 LTA 的患者在住院期间使用的阿片类药物中位数为 110.3 吗啡毫克当量(四分位数间距为 70.1-144.5),而接受 PRA 的患者使用的阿片类药物中位数为 91.0(四分位数间距为 59.1-133.3)(P = 0.16)。线性回归结果显示,不同方法的术后阿片类药物使用量无明显差异(-9.3吗啡毫克当量[95%置信区间-40.7至22.1]):我们的分析发现,在术后疼痛或阿片类药物使用方面,PRA 与 LTA 相比没有明显优势,这与 Barczyński 等人早前的研究结果相反,他们报告称 PRA 术后疼痛更低。这两种方法显示出相似的临床结果,在两者之间做出选择时应基于患者的个体因素,而不是患者报告的疼痛和阿片类药物使用量的差异。
{"title":"Equivalent Pain and Opioid Use Between Transabdominal and Retroperitoneal Adrenalectomy","authors":"Lauren Haskins DO, MBA ,&nbsp;Nicole Tobin MD ,&nbsp;Elle Reineman ,&nbsp;Rebecca Sippel MD ,&nbsp;David Schneider MD ,&nbsp;Kristin Long MD, MPH ,&nbsp;Dawn Elfenbein MD ,&nbsp;Courtney Balentine MD ,&nbsp;Alexander Chiu MD, MPH","doi":"10.1016/j.jss.2024.10.009","DOIUrl":"10.1016/j.jss.2024.10.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Laparoscopic transabdominal adrenalectomy (LTA) and posterior retroperitoneoscopic adrenalectomy (PRA) are safe, effective surgical approaches. A direct comparison of postoperative pain and narcotic use is needed.</div></div><div><h3>Methods</h3><div>Adults who had laparoscopic adrenalectomy at a tertiary institution from 2015 to 2021 were identified from a surgical database. Evaluated key outcomes included opioid use and patient-reported pain during the perioperative period, which were analyzed by surgical approach and compared using multivariate linear regression. Additional data on pain postdischarge, prescription refills, length of stay, and 30-d readmission were also collected.</div></div><div><h3>Results</h3><div>Eighty-eight (69.3%) surgeries were LTA and 39 (30.7%) were PRA. The studied patient population was 58% female and had an average age of 54 (standard deviation 13). Adrenal tumors were 75% functional and 3.4 cm on average (standard deviation 2.6). Postoperative pain scores at rest (4.4 LTA <em>versus</em> 4.5 PRA, <em>P</em> = 0.87) and activity (4.7 LTA <em>versus</em> 5.6 PRA, <em>P</em> = 0.08) did not reach statistical significance. Patients undergoing LTA used a median of 110.3 morphine milligram equivalents (interquartile range 70.1-144.5) of opioids during their hospital stay compared to 91.0 (interquartile range 59.1-133.3) for PRA (<em>P</em> = 0.16). Linear regression demonstrated no significant difference in postoperative opioid use between approaches (−9.3 morphine milligram equivalents [95% confidence interval −40.7 to 22.1]).</div></div><div><h3>Conclusions</h3><div>Our analysis found no significant advantage of PRA over LTA in terms of postoperative pain or opioid use, contrary to earlier findings by Barczyński <em>et al.</em>, who reported lower postoperative pain with PRA. Both approaches show similar clinical outcomes, and the choice between them should be based on individual patient factors rather than differences in patient-reported pain and opioid usage.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"304 ","pages":"Pages 173-180"},"PeriodicalIF":1.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholecystectomy Is a Risk Factor for Proximal Colon Cancer That May Also Relate to its Aggressiveness 胆囊切除术是近端结肠癌的一个风险因素,也可能与其侵袭性有关。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-15 DOI: 10.1016/j.jss.2024.10.018
Raymundo A. Muñoz MD , Andrei A. Ramos MD , Francisco J. Miranda MD , José E. De La Rosa MD , Alfonzo E. Muñoz BS , Aáron A. Ramírez MD , Eva P. Chavez MD , Guillermo Gallardo MD, FACS , Salvador Pizarro MD

Introduction

There are studies with mixed conclusions about the role cholecystectomy plays as a risk factor for proximal colorectal cancer (CRC).

Methods

We performed a multicenter retrospective cohort study where the records of patients with CRC were reviewed. Data was collected regarding affected colon subsegment (cecum, ascending, transverse, descending, sigmoid, or rectum, which were also combined into proximal or distal colon), history and time since cholecystectomy, histopathology reports (TNM classification and clinical stage), and KRAS, NRAS, and BRAF mutation analysis. Univariate and multivariate analysis adjusting for age, smoking history, body mass index, sex, and family history of cancer were performed. Logistical regression for statistical analysis was used to estimate the odds ratio for the association between cholecystectomy and tumor location.

Results

Four hundred four cases were obtained, of which 52 previously had cholecystectomy. The date of surgery was recorded in 43 patients, with a 5 y median and an interquartile range of 1.5-14 y prior to CRC diagnosis. Both crude and adjusted odds ratio (2.86 and 2.42, respectively) confirmed an associated risk for developing proximal CRC after cholecystectomy. When proximal CRC cases with previous cholecystectomy were directly compared against proximal CRC without cholecystectomy and distal CRC cases, the former had a higher distribution of prevalence for T3, T4b, N1b, M1a, and M1c. KRAS mutation also presented its highest prevalence in this group with 33%.

Conclusions

Cholecystectomy was related to the development of proximal CRC in all its subsegments, seemingly associated with higher stages at diagnosis. Close surveillance should be considered in patients who undergo cholecystectomy.
导言:关于胆囊切除术作为近端结直肠癌(CRC)风险因素的作用,研究结论不一:我们进行了一项多中心回顾性队列研究,审查了 CRC 患者的病历。收集的数据涉及受影响的结肠亚段(盲肠、升结肠、横结肠、降结肠、乙状结肠或直肠,也可合并为近端或远端结肠)、胆囊切除术后的病史和时间、组织病理学报告(TNM 分类和临床分期)以及 KRAS、NRAS 和 BRAF 基因突变分析。对年龄、吸烟史、体重指数、性别和癌症家族史进行了单变量和多变量分析。统计分析采用了逻辑回归法,以估算胆囊切除术与肿瘤位置之间的相关性的几率:结果:共获得 44 个病例,其中 52 人曾接受过胆囊切除术。43例患者的手术日期有记录,中位数为5年,四分位数范围为1.5-14年。粗略赔率和调整赔率(分别为 2.86 和 2.42)都证实了胆囊切除术后患近端 CRC 的相关风险。将曾接受过胆囊切除术的近端 CRC 病例与未接受过胆囊切除术的近端 CRC 病例和远端 CRC 病例进行直接比较,发现前者的 T3、T4b、N1b、M1a 和 M1c 患病率分布较高。KRAS突变在该组中的发病率也最高,为33%:结论:胆囊切除术与所有亚组近端 CRC 的发生有关,似乎与诊断时的较高分期有关。应考虑对接受胆囊切除术的患者进行密切监测。
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引用次数: 0
Corrigendum to "Gender Parity Among Vascular Surgeons: Progress and Attrition" [Journal of Surgical Research, Volume 303 (2024) P281-286]. 血管外科医生的性别均等:进展与流失》[《外科研究杂志》,第 303 卷(2024 年),P281-286]。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-14 DOI: 10.1016/j.jss.2024.10.022
Elisa Bass, Scott Anderson, Braden C Hintze, Young Erben
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引用次数: 0
Effects of Novel Cross-Linked Chondroitin Sulfate (SI-449) as a Postoperative Anti-Adhesion Barrier 新型交联硫酸软骨素(SI-449)作为术后抗粘连屏障的效果。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-14 DOI: 10.1016/j.jss.2024.10.016
Kei Toyama PhD , Katsuya Takahashi BS , Sho Funayama MS , Keiji Yoshioka PhD

Introduction

Postoperative adhesion often develops as a natural physiological response following abdominal and pelvic surgeries. Although existing resorbable adhesion barriers have reduced the incidence of postoperative adhesion formation, their clinical efficacy requires improvement. In this study, we generated a novel cross-linked, powder-formed chondroitin sulfate (SI-449) as an effective postoperative anti-adhesion barrier. We evaluated its anti-adhesion effect in animal models of abdominal and pelvic surgeries and elucidated its mechanism of action.

Methods

Rats in the cecum-abraded adhesion and uterine horn adhesion models were treated with SI-449 and Seprafilm, and adhesion frequency and scores were evaluated. The mechanisms underlying this anti-adhesion effect were examined histopathologically using a cecum-abraded adhesion model.

Results

In the cecum-abraded adhesion model, SI-449 reduced the adhesion frequency and total adhesion score to 30% and 1.6, respectively, compared with 100% and 8.1 in the control group and 50% and 2.5 in the Seprafilm group. We observed an SI-449-like substance between the cecum and abdominal wall and no fibrin net structure connecting the invasive tissues after surgery, as observed in the control group. In the rat uterine horn adhesion model, SI-449 reduced the adhesion frequency to 40%, compared with 100% in the control.

Conclusions

SI-449 exhibits anti-adhesion activity in animal models of postoperative adhesion. The mechanism of action of SI-449 during wound healing suggests mechanical obstruction of fibrin net structure formation, which is a key step in the development of adhesions at surgical sites. SI-449 is a promising candidate for preventing postoperative adhesions in clinical practice.
导言:术后粘连通常是腹部和盆腔手术后的一种自然生理反应。尽管现有的可吸收粘连屏障已降低了术后粘连形成的发生率,但其临床疗效仍有待提高。在本研究中,我们生成了一种新型交联粉末状硫酸软骨素(SI-449),作为有效的术后防粘连屏障。我们在腹部和盆腔手术动物模型中评估了其抗粘连效果,并阐明了其作用机制:方法:用 SI-449 和 Seprafilm 处理盲肠破损粘连和子宫角粘连模型中的大鼠,并评估粘连频率和评分。结果:结果:在盲肠破损粘附模型中,SI-449 将粘附频率和粘附总分分别降低至 30% 和 1.6,而对照组分别为 100% 和 8.1,Seprafilm 组分别为 50% 和 2.5。我们观察到盲肠和腹壁之间有类似 SI-449 的物质,术后没有纤维蛋白网结构连接侵入组织,这与对照组的观察结果相同。在大鼠子宫角粘连模型中,SI-449 可将粘连频率降至 40%,而对照组的粘连频率为 100%:结论:SI-449在术后粘连动物模型中具有抗粘连活性。SI-449在伤口愈合过程中的作用机制表明,机械性阻碍了纤维蛋白网状结构的形成,而纤维蛋白网状结构的形成是手术部位发生粘连的关键步骤。在临床实践中,SI-449 是一种有希望预防术后粘连的候选药物。
{"title":"Effects of Novel Cross-Linked Chondroitin Sulfate (SI-449) as a Postoperative Anti-Adhesion Barrier","authors":"Kei Toyama PhD ,&nbsp;Katsuya Takahashi BS ,&nbsp;Sho Funayama MS ,&nbsp;Keiji Yoshioka PhD","doi":"10.1016/j.jss.2024.10.016","DOIUrl":"10.1016/j.jss.2024.10.016","url":null,"abstract":"<div><h3>Introduction</h3><div>Postoperative adhesion often develops as a natural physiological response following abdominal and pelvic surgeries. Although existing resorbable adhesion barriers have reduced the incidence of postoperative adhesion formation, their clinical efficacy requires improvement. In this study, we generated a novel cross-linked, powder-formed chondroitin sulfate (SI-449) as an effective postoperative anti-adhesion barrier. We evaluated its anti-adhesion effect in animal models of abdominal and pelvic surgeries and elucidated its mechanism of action.</div></div><div><h3>Methods</h3><div>Rats in the cecum-abraded adhesion and uterine horn adhesion models were treated with SI-449 and Seprafilm, and adhesion frequency and scores were evaluated. The mechanisms underlying this anti-adhesion effect were examined histopathologically using a cecum-abraded adhesion model.</div></div><div><h3>Results</h3><div>In the cecum-abraded adhesion model, SI-449 reduced the adhesion frequency and total adhesion score to 30% and 1.6, respectively, compared with 100% and 8.1 in the control group and 50% and 2.5 in the Seprafilm group. We observed an SI-449-like substance between the cecum and abdominal wall and no fibrin net structure connecting the invasive tissues after surgery, as observed in the control group. In the rat uterine horn adhesion model, SI-449 reduced the adhesion frequency to 40%, compared with 100% in the control.</div></div><div><h3>Conclusions</h3><div>SI-449 exhibits anti-adhesion activity in animal models of postoperative adhesion. The mechanism of action of SI-449 during wound healing suggests mechanical obstruction of fibrin net structure formation, which is a key step in the development of adhesions at surgical sites. SI-449 is a promising candidate for preventing postoperative adhesions in clinical practice.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"304 ","pages":"Pages 162-172"},"PeriodicalIF":1.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Reading Times of RFID-Tagged and Barcode-Engraved Surgical Instruments 比较 RFID 标签和条形码刻印手术器械的读取时间。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-13 DOI: 10.1016/j.jss.2024.09.087
Kaori Kusuda DSci , Kazuhiko Yamashita DEng , Emiko Morishita BN , Nao Ishibashi BN , Yoshito Shiraishi MD, DMed , Hiromitsu Yamaguchi MD, DMed

Introduction

To improve patient safety and reduce burden on healthcare professionals and institutions, the individual management of surgical instruments is essential. There are two methods for individual item management: radio-frequency identification (RFID) and barcoding. However, there has been no examination of efficiency regarding reading times. Therefore, this study aimed to compare the reading times of RFID-tagged and barcode-engraved surgical instruments and evaluate the influence of operator proficiency.

Methods

The participants included 8 individuals and 41 surgical instruments from a varicose vein set. RFID tags and barcodes were attached to the surgical instruments. Five trials were conducted for each, and the reading times were measured.

Results

The reading times for RFID-tagged surgical instruments in the skilled and unskilled groups were 64.0 ± 9.0s and 79.4 ± 17.0 s, respectively, whereas those for barcode-engraved surgical instruments were 190.4 ± 28.1 s and 212.3 ± 40.3 s, respectively. Barcodes took 3.0 and 2.7 times longer to read than RFID-tagged instruments for the skilled and unskilled groups, respectively. Additionally, skilled operators using barcodes required 2.4 times more time than unskilled operators using RFID. Even nonmedical individuals were able to achieve quick and accurate readings with RFID. The estimated labor hours per person were $24,146-$42,322 for RFID and $71,078-$110,898 for barcode scanning for a year (working 8 h/d for 250 d).

Conclusions

RFID-tagged surgical instruments impose a lighter workload and financial burden than barcode-engraved surgical instruments. RFID technology may also improve patient safety due to less dependency on operator proficiency.
导言:为了提高患者安全,减轻医护人员和医疗机构的负担,对手术器械进行单独管理至关重要。单个物品管理有两种方法:射频识别(RFID)和条形码。然而,目前还没有关于读取时间效率的研究。因此,本研究旨在比较 RFID 标签和条形码刻印手术器械的读取时间,并评估操作员熟练程度的影响:参与者包括 8 个人和 41 件静脉曲张手术器械。手术器械上分别贴有 RFID 标签和条形码。结果:贴有 RFID 标签的手术器械的读取时间短于贴有条形码的手术器械的读取时间:结果:熟练组和非熟练组的 RFID 标签手术器械的读取时间分别为 64.0 ± 9.0 秒和 79.4 ± 17.0 秒,而刻有条形码的手术器械的读取时间分别为 190.4 ± 28.1 秒和 212.3 ± 40.3 秒。熟练组和非熟练组读取条形码所需的时间分别是 RFID 标签器械的 3.0 倍和 2.7 倍。此外,使用条形码的熟练操作员所需的时间是使用 RFID 的非熟练操作员的 2.4 倍。即使是非医务人员也能使用 RFID 快速准确地读取数据。一年下来,RFID 的人均工时估计为 24,146 美元至 42,322 美元,条形码扫描的人均工时估计为 71,078 美元至 110,898 美元(250 天/天,每天工作 8 小时):RFID 标签手术器械比条形码标签手术器械的工作量和经济负担更轻。RFID 技术还可减少对操作人员熟练程度的依赖,从而提高患者安全。
{"title":"Comparison of Reading Times of RFID-Tagged and Barcode-Engraved Surgical Instruments","authors":"Kaori Kusuda DSci ,&nbsp;Kazuhiko Yamashita DEng ,&nbsp;Emiko Morishita BN ,&nbsp;Nao Ishibashi BN ,&nbsp;Yoshito Shiraishi MD, DMed ,&nbsp;Hiromitsu Yamaguchi MD, DMed","doi":"10.1016/j.jss.2024.09.087","DOIUrl":"10.1016/j.jss.2024.09.087","url":null,"abstract":"<div><h3>Introduction</h3><div>To improve patient safety and reduce burden on healthcare professionals and institutions, the individual management of surgical instruments is essential. There are two methods for individual item management: radio-frequency identification (RFID) and barcoding. However, there has been no examination of efficiency regarding reading times. Therefore, this study aimed to compare the reading times of RFID-tagged and barcode-engraved surgical instruments and evaluate the influence of operator proficiency.</div></div><div><h3>Methods</h3><div>The participants included 8 individuals and 41 surgical instruments from a varicose vein set. RFID tags and barcodes were attached to the surgical instruments. Five trials were conducted for each, and the reading times were measured.</div></div><div><h3>Results</h3><div>The reading times for RFID-tagged surgical instruments in the skilled and unskilled groups were 64.0 ± 9.0s and 79.4 ± 17.0 s, respectively, whereas those for barcode-engraved surgical instruments were 190.4 ± 28.1 s and 212.3 ± 40.3 s, respectively. Barcodes took 3.0 and 2.7 times longer to read than RFID-tagged instruments for the skilled and unskilled groups, respectively. Additionally, skilled operators using barcodes required 2.4 times more time than unskilled operators using RFID. Even nonmedical individuals were able to achieve quick and accurate readings with RFID. The estimated labor hours per person were $24,146-$42,322 for RFID and $71,078-$110,898 for barcode scanning for a year (working 8 h/d for 250 d).</div></div><div><h3>Conclusions</h3><div>RFID-tagged surgical instruments impose a lighter workload and financial burden than barcode-engraved surgical instruments. RFID technology may also improve patient safety due to less dependency on operator proficiency.</div></div>","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"304 ","pages":"Pages 121-125"},"PeriodicalIF":1.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association for Academic Surgery: The Gateway to Transformative Leadership in American Surgery 外科学术协会:美国外科变革领导力的门户。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-13 DOI: 10.1016/j.jss.2024.10.013
Henri R. Ford MD, MHA, FACS, MAMSE, FRCS(Eng), FWACS, FAAP
{"title":"The Association for Academic Surgery: The Gateway to Transformative Leadership in American Surgery","authors":"Henri R. Ford MD, MHA, FACS, MAMSE, FRCS(Eng), FWACS, FAAP","doi":"10.1016/j.jss.2024.10.013","DOIUrl":"10.1016/j.jss.2024.10.013","url":null,"abstract":"","PeriodicalId":17030,"journal":{"name":"Journal of Surgical Research","volume":"304 ","pages":"Pages 147-151"},"PeriodicalIF":1.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adjuvant Radioactive Iodine Ablation in Tall Cell Subtype Papillary Thyroid Cancer: A Systematic Review and Meta-analysis 高细胞亚型甲状腺乳头状癌的放射性碘消融辅助治疗:系统回顾与元分析》。
IF 1.8 3区 医学 Q2 SURGERY Pub Date : 2024-11-13 DOI: 10.1016/j.jss.2024.10.010
Phillip Staibano MD MSc , Michael K. Gupta MD MSc FRCSC , Fay Alresaini MD , Michael Au MD MHI FRCSC , Keean Nanji MD , Emily Oulousian , Maya Senthilkumaran BHSc , Sarah Oulousian , Jesse D. Pasternak MD MPH FRCSC , Tyler McKechnie MD MSc , Eric Monteiro MD MSc FRCSC , Alex Thabane MSc , Han Zhang MD FRCSC

Introduction

Tall cell subtype papillary thyroid cancer (TCS-PTC) is associated with aggressive disease features and worse patient outcomes. It remains unclear whether adjuvant radioactive iodine (RAI) ablation following thyroidectomy is associated with improved survival in TCS-PTC. The purpose of this review and meta-analysis was to determine whether adjuvant RAI was associated with improved survival in patients with TCS-PTC.

Methods

We included any study design that investigated survival outcomes in adult patients diagnosed with TCS-PTC who underwent either thyroidectomy following by adjuvant RAI or thyroidectomy alone. We searched MEDLINE, EMBASE, Scopus, and CENTRAL databases from inception with no restrictions. All screening and review stages were performed in duplicate. Risk of bias was evaluated using ROBINS-I and certainty of evidence were evaluated using GRADE. Meta-analysis was performed using a random effects model and we calculated pooled hazard ratios (HRs), where applicable. All analyses were performed in RevMan 5.3 (Cochrane, UK).

Results

Seven nonrandomized studies were included with 9611 TCS-PTC patients, of which 6296 (65.5%) underwent adjuvant RAI. All studies were at high risk of bias. Based on low certainty evidence, we found that adjuvant RAI was possibly associated with improved overall survival in TCS-PTC (HR = 0.60, 95% confidence interval: 0.42-0.85). This benefit was maintained in studies that performed propensity score matching, but we did not find a significant association with tumor size. Sensitivity analysis to remove studies with potentially overlapping data changed the HR to 0.74 (95% CI: 0.46-1.19) with considerable heterogeneity (I2 = 70%). Based on very low certainty evidence, we were uncertain where adjuvant RAI was associated with cancer-specific or recurrence-free survival.

Conclusions

Adjuvant RAI may be associated with improved overall survival in TCS-PTC, but future high-quality randomized studies with risk stratification are needed.
导言:高细胞亚型甲状腺乳头状癌(TCS-PTC)具有侵袭性疾病特征,患者预后较差。目前仍不清楚甲状腺切除术后辅助放射性碘(RAI)消融是否与TCS-PTC生存率的提高有关。本综述和荟萃分析旨在确定辅助 RAI 是否与 TCS-PTC 患者生存率的提高有关:我们纳入了所有研究设计,这些设计调查了确诊为 TCS-PTC 的成年患者在接受甲状腺切除术后辅助 RAI 或单独接受甲状腺切除术的生存结果。我们对 MEDLINE、EMBASE、Scopus 和 CENTRAL 数据库进行了无限制检索。所有筛选和审查阶段均一式两份。使用 ROBINS-I 评估偏倚风险,使用 GRADE 评估证据的确定性。采用随机效应模型进行 Meta 分析,并酌情计算汇总危险比 (HR)。所有分析均在RevMan 5.3(Cochrane,英国)中进行:共纳入了 7 项非随机研究,9611 名 TCS-PTC 患者接受了 RAI 辅助治疗,其中 6296 人(65.5%)接受了 RAI 辅助治疗。所有研究均存在高偏倚风险。基于低确定性证据,我们发现辅助 RAI 可能与 TCS-PTC 总生存率的改善有关(HR = 0.60,95% 置信区间:0.42-0.85)。在进行倾向评分匹配的研究中,这种益处得以保持,但我们没有发现与肿瘤大小有显著关联。通过敏感性分析剔除数据可能重叠的研究后,HR 变为 0.74(95% 置信区间:0.46-1.19),异质性相当大(I2 = 70%)。基于确定性极低的证据,我们无法确定辅助 RAI 与癌症特异性生存或无复发生存的相关性:结论:RAI辅助治疗可能与TCS-PTC总生存率的改善有关,但未来还需要进行风险分层的高质量随机研究。
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引用次数: 0
期刊
Journal of Surgical Research
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