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Maintaining Survival While Improving Quality of Life: An Advanced Practitioner–Led Pilot Feasibility Study to Reduce Radiation Dose in Children With Brain Tumors 提高生活质量的同时维持生存:由高级医师领导的降低儿童脑肿瘤患者放射剂量的试点可行性研究
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.1.3
Jennifer L. Raybin, PhD, RN, CPNP, Andrew Donson, Nicholas K. Foreman, MRCP, Rajeev Vibhakar, MD, Michael H. Handler, MD, Arthur K. Liu, MD, PhD
Purpose: Oncology advanced practitioners (APs) are on the front line in treating adverse effects. Among children with brain tumors, treatments such as craniospinal irradiation (CSI) cause neurocognitive injury, endocrinopathies, and ototoxicity. High-dose CSI with concurrent chemotherapy allows high-risk embryonal tumors (non-anaplastic) good survival (70%), but significant distressing effects are commonly treated by APs in multidisciplinary long-term follow-up. The aim of this study was to test feasibility of reducing radiation dose with an AP-led protocol. Methods: An interdisciplinary team developed this pilot study with the primary outcome of fewer than two deaths in 10 patients (80% survival). Secondary outcomes were feasibility of an AP-led treatment protocol and acute/late effects of treatment. The AP held a pioneering role as principal investigator of a tumor treatment study. Exclusion criteria included age less than 3 years and anaplasia. The CSI was reduced from 36 to 24 Gy. All other treatment was standard. Results: Survival rate exceeded the primary outcome threshold (88%); the accrual rate (80%) and follow-up neurocognitive testing rate (75%) were acceptable. Eight children ages 3 to 19 years (M = 8) with tumors of varied molecular subtyping were enrolled. The single death occurred 2.5 years from diagnosis of multiorgan failure (without evidence of tumor). The mean survival is 11 years, with two college and one graduate degrees. Acute and late effects were decreased compared with the higher-dose CSI. Conclusion: APs who treat cancer adverse effects can also conduct clinical prospective studies to maintain survival rates and improve quality-of life-outcomes.
目的:肿瘤科高级医师(APs)处于治疗不良反应的第一线。在脑肿瘤患儿中,颅骨照射(CSI)等治疗方法会导致神经认知损伤、内分泌病变和耳毒性。大剂量 CSI 并发化疗可使高危胚胎性肿瘤(非无性细胞性)获得良好的生存率(70%),但在多学科长期随访中,APs 通常会治疗明显的不良反应。本研究的目的是测试以全科医生为主导的方案减少放射剂量的可行性。方法:一个跨学科团队开展了这项试点研究,主要结果是 10 名患者中死亡人数少于 2 人(存活率为 80%)。次要结果是由介入治疗师主导的治疗方案的可行性和治疗的急性/晚期效应。作为肿瘤治疗研究的主要研究者,AP 发挥了先锋作用。排除标准包括年龄小于 3 岁和无增生。CSI从36Gy降至24Gy。所有其他治疗均为标准治疗。结果:存活率超过了主要结果阈值(88%);应计率(80%)和随访神经认知测试率(75%)均可接受。8 名 3 至 19 岁的儿童(男 = 8)患有不同分子亚型的肿瘤。其中一名患儿在确诊后2.5年因多器官功能衰竭死亡(无肿瘤证据)。平均生存期为 11 年,其中两人获得大学学位,一人获得研究生学位。与高剂量的 CSI 相比,急性和晚期效应均有所降低。结论:治疗癌症不良反应的介入治疗师也可以开展临床前瞻性研究,以维持生存率并提高生活质量。
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引用次数: 0
Advanced Practice Providers’ Role in Intimacy in Advanced Cancer Patients 进修医生在晚期癌症患者亲密关系中的作用
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.1.6
Anna Poullard, DNP, MSN, APRN-BC, Sheena Charles, MS, FNP-BC
The primary objectives of early phase clinical trials are to determine the safety, tolerability, and recommended doses of an investigational agent for patients with advanced cancer. Although these advances in cancer treatment have resulted in patients living longer, patients often experience psychological side effects that may affect sexual health and intimacy. It is estimated that cancer and its subsequent treatments affect the sexual health and intimacy of 40% to 100% of this patient population. Patients with advanced cancer who have undergone numerous treatments may be impacted negatively, not only physically (such as being disfigured by surgical resection) but also emotionally in relationship aspects with their intimate partners. Health-care providers who treat patients with advanced cancer enrolled in early phase clinical trials tend to focus primarily on treatment, physical side effects, and symptom management. Advanced practice providers (APPs) are accustomed to performing comprehensive physical examinations on patients; however, research indicates that intimacy and sexuality are most often excluded in discussions with patients with advanced cancer. The purpose of the article is to increase awareness of the need to address intimacy and sexuality in this patient population and to encourage APPs to make this a part of their everyday practice.
早期临床试验的主要目的是确定研究药物对晚期癌症患者的安全性、耐受性和推荐剂量。虽然癌症治疗的进步使患者的寿命延长,但患者经常会出现心理副作用,这可能会影响性健康和亲密关系。据估计,癌症及其后续治疗会影响 40% 到 100% 的患者的性健康和亲密关系。接受过多次治疗的晚期癌症患者可能会受到负面影响,不仅是身体上的(如因手术切除而毁容),还有与亲密伴侣在感情方面的。为参加早期临床试验的晚期癌症患者提供治疗的医护人员往往主要关注治疗、身体副作用和症状控制。高级医疗服务提供者(APP)习惯于对患者进行全面的身体检查;然而,研究表明,在与晚期癌症患者进行讨论时,亲密关系和性行为往往被排除在外。这篇文章旨在提高人们对在这一患者群体中处理亲密关系和性行为的必要性的认识,并鼓励全科医生将其作为日常工作的一部分。
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引用次数: 0
Clinical Posters From JADPRO Live 2023 来自 JADPRO Live 2023 的临床海报
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.1.8
Thirty-three clinical posters focused on the role of the advanced practitioner were presented at JADPRO Live this past November 9 to 12, 2023, in Orlando, Florida.
在 2023 年 11 月 9 日至 12 日于佛罗里达州奥兰多市举行的 JADPRO 现场会议上,展示了 33 篇以高级医师的作用为主题的临床海报。
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引用次数: 0
The Cost of Care: Financial and Social Factors in Cancer Management 护理成本:癌症管理中的经济和社会因素
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.1.1
Beth Faiman, PhD, MSN, APRN-BC, AOCN, BMTCN, FAAN, FAPO
It is known among clinicians, including advanced practitioners (APs), that non-medical factors will influence health outcomes and contribute to health disparities. Factors such as socioeconomic position, access to health-care and education systems, and living conditions impact whether a patient will be provided similar treatment, care, or resources as others with the same condition. These are referred to as social determinants of health (SDOHs), and negative social factors lead to patients experiencing deleterious outcomes (Pinheiro et al., 2022).
临床医生(包括高级执业医师)都知道,非医疗因素会影响健康结果并造成健康差异。社会经济地位、获得医疗保健和教育系统的机会以及生活条件等因素都会影响患者是否会获得与其他病情相同的患者类似的治疗、护理或资源。这些因素被称为健康的社会决定因素(SDOHs),负面的社会因素会导致患者经历有害的结果(Pinheiro et al.)
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引用次数: 0
Clinical Posters From JADPRO Live 2023 来自 JADPRO Live 2023 的临床海报
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.1.8
Thirty-three clinical posters focused on the role of the advanced practitioner were presented at JADPRO Live this past November 9 to 12, 2023, in Orlando, Florida.
在 2023 年 11 月 9 日至 12 日于佛罗里达州奥兰多市举行的 JADPRO 现场会议上,展示了 33 篇以高级医师的作用为主题的临床海报。
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引用次数: 0
Peripheral T-Cell Lymphoma, Not Otherwise Specified: Diagnosis and Therapeutic Approaches for the Advanced Practice Provider 外周 T 细胞淋巴瘤,未另作说明:高级医疗人员的诊断和治疗方法
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.8.3
Karla V. Ow, MSN, APRN, AOCNP, Ann Vo, MSN, APRN, FNP, Jonathan Cunningham, MPAS, PA-C
T-cell lymphomas (TCLs) have a unique pathobiology, clinically aggressive course, and poor prognosis. Recently, there have been significant advances in understanding the molecular genetic alterations of TCLs through next-generation sequencing. This has led to the development of specific therapeutic molecules. This review aims to provide an up-to-date overview of the current therapeutic approaches for the subtype peripheral T-cell lymphoma, not otherwise specified.
T细胞淋巴瘤(TCL)具有独特的病理生物学特性、临床侵袭性病程和不良预后。最近,通过新一代测序技术,人们在了解 TCL 的分子基因改变方面取得了重大进展。这促进了特异性治疗分子的开发。本综述旨在概述目前治疗非特异性外周T细胞淋巴瘤亚型的最新方法。
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引用次数: 0
Does Use of Intratumoral Injections in Solid Tumor Malignancies Improve Outcomes and Reduce Adverse Events? An Integrative Review 在实体瘤恶性肿瘤中使用瘤内注射能改善疗效并减少不良反应吗?综述
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.1.4
Maggie Matyola, APRN, FNP-C, Ashley Martinez, DNP, APRN, FNP-BC, Joyce Dains, DrPH, JD, APRN, FNP-BC, FNAP, FAANP, FAAN
The purpose of this review is to assess the efficacy and adverse events associated with intratumoral injection in the treatment of solid tumor malignancies. A literature review was conducted using PubMed, the Cochrane Database of Systematic Reviews, CINAHL, and Scopus databases from 2009 to 2022. A total of 588 articles were retrieved, with five selected based on inclusion and exclusion criteria. Inclusion criteria specified English language publications, in human trials, and use of intratumoral anticancer agents. The findings from this integrative review demonstrate treatment efficacy as measured by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria with increased stable disease and partial response in patients as well as a prolonged survival period. Additionally, findings show that this therapy is associated with predominantly mild adverse events.
本综述旨在评估瘤内注射治疗实体瘤恶性肿瘤的疗效和相关不良反应。我们使用 PubMed、Cochrane 系统综述数据库、CINAHL 和 Scopus 数据库对 2009 年至 2022 年期间的文献进行了综述。共检索到 588 篇文章,根据纳入和排除标准筛选出 5 篇。纳入标准为英文出版物、人体试验和使用瘤内抗癌药物。根据实体瘤反应评估标准(RECIST)1.1 标准,本综合综述的研究结果显示了治疗效果,患者病情稳定和部分反应增加,生存期延长。此外,研究结果表明,这种疗法主要伴有轻微的不良反应。
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引用次数: 0
Guess What Is in My Brain 猜猜我脑子里有什么
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.1.7
Catherine Joseph, MSN, APN, AGACNP-BC
Magnetic resonance imaging (MRI) of the brain is an important diagnostic tool used by neurologists. This article explores the workup and management for a patient with a brain lesion and highlights the importance of neuroimaging. Similarities and differences in MRI findings for meningioma, central nervous system lymphoma, and glioblastomas are discussed, along with common MRI sequences and their utility.
脑部磁共振成像(MRI)是神经科医生使用的重要诊断工具。本文探讨了脑部病变患者的检查和治疗方法,并强调了神经影像学检查的重要性。文章讨论了脑膜瘤、中枢神经系统淋巴瘤和胶质母细胞瘤 MRI 检查结果的异同,以及常见的 MRI 序列及其用途。
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引用次数: 0
A Financial Toxicity Screening and Care Coordination Quality Improvement Program in a Gynecology Oncology Urban Practice 妇科肿瘤学城市诊所的财务毒性筛查和护理协调质量改进计划
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.1.2
Tina Harris, DNP, NP-C, AOCNP, Julie Brinzo, DNP, APRN, MBA, FNP-C, Christopher Pell, PhD
Background: Educating a multidisciplinary team on financial toxicity (FT) risk, screening, and care coordination is an approach to addressing gaps in care among newly diagnosed patients with stage III or IV cancer. Objective: The goal of this quality improvement project (QIP) was to supply an education program for the multidisciplinary team providing insights for the following objectives: (1) Increase the rate of FT screening where there was no baseline screening, (2) Increase referrals for resource care coordination among patients experiencing FT, and (3) Evaluate the relationship between FT and selected demographic identifiers during the 8-week project. Methods: The Plan-Do-Study-Act (PDSA) model was adopted for learning and leading the change during the QIP, focusing on the COmprehensive Score for financial Toxicity (COST) and resource care coordination for newly diagnosed participants with stage III or IV gynecologic cancer. Results: Of the 42 (80.75%) participants consenting to the QIP, 61.90% had COST scores below 23, with 100% (26) of the participants receiving referrals for resource care coordination. On average, 6.50 patients enter the practice for care, with 50% (3.25) reporting FT. At this rate, 162.50 patients were experiencing FT in a 50-week year and were not receiving resource care coordination. However, because some patients did not consent to the QIP, the average FT (Yes) count could potentially be between 199.50 to 225.00 patients in a 50-week year, leading to a potential 62.50 with FT (or 28% of 225.00) not receiving referrals. Age was the main driver for FT COST Score in this QIP. Many variables were unobserved in this QIP and could impact the FT COST Score. However, separate modeling reveals that age alone explains approximately 15% of FT COST scores’ observed changes. Controlling for more variables may refine the model, but it seems unlikely by the data analysis that age would disappear as a driver of change in the FT COST score. Conclusion: Developing a multidisciplinary education program focusing on a structured QIP-PDSA plan can be an example of standardizing an FT screening and care coordination program. The QIP team successfully incorporated a PDSA model roadmap screening program to identify the participants experiencing FT and promptly referred 100% for resource care coordination.
背景:对多学科团队进行经济毒性(FT)风险、筛查和护理协调方面的教育,是解决新诊断的 III 期或 IV 期癌症患者护理差距的一种方法。目标:本质量改进项目(QIP)的目标是为多学科团队提供一项教育计划,为实现以下目标提供启示:(1)提高未进行基线筛查的财务毒性筛查率;(2)在出现财务毒性的患者中增加资源护理协调转介;以及(3)在为期 8 周的项目中评估财务毒性与所选人口统计学识别指标之间的关系。方法:采用 "计划-实施-研究-行动"(Plan-Do-Study-Act,PDSA)模式来学习和引导 QIP 期间的变革,重点关注财务毒性综合评分(COST)和新诊断的 III 期或 IV 期妇科癌症参与者的资源护理协调。结果:在 42 名(80.75%)同意参加 QIP 的参与者中,61.90% 的 COST 评分低于 23 分,100%(26 名)的参与者接受了资源护理协调转介。平均有 6.50 名患者进入诊所接受治疗,其中 50%(3.25 人)报告有家庭病史。按此比例计算,在 50 周的一年中,有 162.50 名患者经历了 FT,但未接受资源护理协调。然而,由于部分患者未同意参与 QIP,在 50 周的一年中,FT(是)患者的平均人数可能在 199.50 到 225.00 之间,从而导致可能有 62.50 名 FT 患者(或 225.00 患者中的 28%)未接受转介。在这一质量改进项目中,年龄是影响固定电话转诊成本得分的主要因素。在这一质量改进项目中,许多变量都是不可观测的,可能会影响固定电话成本得分。然而,单独建模显示,年龄本身就能解释所观察到的 FT COST 分数变化的约 15%。对更多变量的控制可能会使模型更加完善,但从数据分析来看,年龄作为 FT COST 分数变化的驱动因素似乎不太可能消失。结论制定一项以结构化 QIP-PDSA 计划为重点的多学科教育计划,可以作为规范 FT 筛查和护理协调计划的一个范例。QIP 团队成功地将 PDSA 模型路线图筛查计划纳入其中,识别出了出现 FT 的参与者,并及时将 100% 的参与者转介到资源护理协调机构。
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引用次数: 0
Fostering Oral Chemotherapy Understanding and Safety (FOCUS) Project: Interventions for Improving Knowledge and Compliance With National Safety Standards 促进口服化疗理解和安全(FOCUS)项目:提高对国家安全标准的认识和遵守情况的干预措施
Pub Date : 2024-02-01 DOI: 10.6004/jadpro.2024.15.8.1
Jessica MacIntyre, DNP, MBA, APRN, NP-C, AOCNP, Rita D'Aoust, PhD, MS, RN, Deborah Baker, DNP, CRNP, NEA-BC, Ginger Hanson, PhD, MS, Lauren Gjolaj, RN, MBA, Lawrence Negret, MD, Daniel O'Neil, MD
Background: Oral chemotherapy drug development and use has increased, and evidence in the literature suggests variability in practices nationally. Thus, there is a need for continuous review of the process of oral chemotherapy administration that focuses on improving adherence to national standards. Objectives: This quality improvement project evaluated provider and staff general knowledge on oral chemotherapy and national safety standards and the implementation and ease of use of an electronic medical record (EMR)-integrated chemotherapy documentation template geared toward improving compliance with national chemotherapy administration standards. Methods: This project utilized a pre-test and post-test design comparing provider and staff knowledge as well as the intervention of a chemotherapy documentation template to assess compliance with national chemotherapy administration safety standards in an academic medical center. Through chart review, 24 national safety standards relevant to oral chemotherapy administration were used to assess compliance prior to and following the introduction of the intervention. Additionally, feasibility, accessibility, and usability of the intervention were evaluated through a validated questionnaire. Findings: Knowledge gained from pre-test to post-test improved (p value of < .001). Additionally, from the 88 charts reviewed, there was a statistical improvement in compliance with national safety standards (p value of < .001). The participants (n = 29) scored the documentation template as above average, indicating overall ease of use and feasibility for continued use.
背景:口服化疗药物的开发和使用日益增多,而文献证据表明,各国的做法不尽相同。因此,有必要对口服化疗药物的给药过程进行持续审查,重点关注如何更好地遵守国家标准。目标:该质量改进项目评估了医疗服务提供者和工作人员对口服化疗和国家安全标准的一般知识,以及电子病历(EMR)集成化疗文件模板的实施和易用性,旨在改善对国家化疗管理标准的遵守情况。方法:该项目采用了前测和后测设计,比较了医疗服务提供者和工作人员的知识以及化疗文件模板的干预情况,以评估一家学术医疗中心是否符合国家化疗管理安全标准。通过病历审查,24 项与口服化疗用药相关的国家安全标准被用于评估干预措施引入前后的合规性。此外,还通过一份经过验证的调查问卷对干预措施的可行性、可及性和可用性进行了评估。研究结果从测试前到测试后,获得的知识有所增加(P 值小于 0.001)。此外,从查阅的 88 份病历来看,在遵守国家安全标准方面有了明显改善(P 值小于 0.001)。参与者(n = 29)对文件模板的评分高于平均水平,这表明该模板总体上易于使用,并具有持续使用的可行性。
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引用次数: 0
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Journal of the Advanced Practitioner in Oncology
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