Pub Date : 2026-01-06Epub Date: 2025-11-19DOI: 10.1016/j.jacc.2025.09.1609
Paul A Heidenreich
{"title":"Giga-Trials Support Vaccination as Secondary Prevention for Cardiovascular Disease.","authors":"Paul A Heidenreich","doi":"10.1016/j.jacc.2025.09.1609","DOIUrl":"10.1016/j.jacc.2025.09.1609","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":"109-111"},"PeriodicalIF":22.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.jacc.2025.11.035
Michael C. Honigberg
{"title":"CHIP, LOY, and Other Clonal Hematopoiesis Subtypes in Cardiovascular Disease","authors":"Michael C. Honigberg","doi":"10.1016/j.jacc.2025.11.035","DOIUrl":"https://doi.org/10.1016/j.jacc.2025.11.035","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"19 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.jacc.2025.09.1502
Louise S. Goodall, Matthew J. Lennon, Perminder S. Sachdev, Philip B. Gorelick, Jason C. Kovacic, Katherine Samaras
{"title":"Current and Emerging Therapeutic Approaches for Vascular Cognitive Impairment and Dementia","authors":"Louise S. Goodall, Matthew J. Lennon, Perminder S. Sachdev, Philip B. Gorelick, Jason C. Kovacic, Katherine Samaras","doi":"10.1016/j.jacc.2025.09.1502","DOIUrl":"https://doi.org/10.1016/j.jacc.2025.09.1502","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"14 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/s0735-1097(25)10362-8
{"title":"Audio Summary","authors":"","doi":"10.1016/s0735-1097(25)10362-8","DOIUrl":"https://doi.org/10.1016/s0735-1097(25)10362-8","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"40 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Frailty is prevalent in patients with heart failure and is associated with adverse outcomes. However, the extent to which the Clinical Frailty Scale (CFS) accurately captures physical and cognitive decline and its prognostic utility in contemporary heart failure care remain uncertain.
Objectives: In this study, the authors sought to examine how well the CFS reflects domains of physical and cognitive function and its association with 2-year all-cause mortality in hospitalized patients with heart failure, using data from the Japanese Registry of Acute Decompensated Heart Failure-Next (JROADHF-NEXT).
Methods: This study involved 3,905 patients from a prospective, nationwide, multicenter registry focusing on hospitalized patients with heart failure (JROADHF-NEXT). Patients were stratified into 6 categories (1-2, 3, 4, 5, 6, and 7-9) according to the CFS. Physical function was assessed using gait speed, the 5-chair stand test, the Short Physical Performance Battery (SPPB), grip strength, and 6-minute walk distance; cognitive function was measured using the Mini-Cog test. The primary outcome was 2-year all-cause mortality after discharge.
Results: Physical function metrics and Mini-Cog scores progressively worsened with increasing CFS severity. Over a 2-year follow-up, 725 patients (18.6%) died, with mortality increasing stepwise with higher CFS scores. Adding CFS to the prognostic model significantly improved discrimination compared with a model based on the SPPB and Mini-Cog test.
Conclusions: The CFS is an independent predictor of 2-year mortality and a robust integrative measure of physical and cognitive vulnerability in patients with heart failure. The CFS provides a practical screening tool that complements formal performance-based frailty assessments in contemporary heart failure management.
背景：虚弱在心力衰竭患者中普遍存在，并与不良后果相关。然而，临床虚弱量表（CFS）准确捕获身体和认知能力下降的程度及其在当代心力衰竭护理中的预后应用仍不确定。目的：在这项研究中，作者利用日本急性失代偿性心力衰竭登记- next （JROADHF-NEXT）的数据，试图检查CFS对住院心力衰竭患者身体和认知功能领域的反映程度及其与2年全因死亡率的关系。方法：这项研究纳入了3905名患者，这些患者来自一个前瞻性的、全国性的、多中心的登记中心，主要关注住院心力衰竭患者（JROADHF-NEXT）。根据CFS将患者分为6类（1-2、3、4、5、6和7-9）。采用步态速度、5椅站立测试、短物理性能电池（SPPB）、握力和6分钟步行距离评估身体功能；认知功能采用Mini-Cog测试。主要终点为出院后2年全因死亡率。结果：随着CFS严重程度的增加，身体功能指标和Mini-Cog评分逐渐恶化。在2年的随访中，725例患者（18.6%）死亡，死亡率随着CFS评分的升高而逐步增加。与基于SPPB和Mini-Cog试验的预测模型相比，将CFS加入预测模型可显著提高识别能力。结论：CFS是心力衰竭患者2年死亡率的独立预测指标，也是身体和认知脆弱性的有力综合衡量指标。CFS提供了一种实用的筛查工具，补充了现代心力衰竭管理中基于绩效的正式虚弱评估。
{"title":"Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure.","authors":"Taisuke Nakade, Yudai Fujimoto, Yu Suresvar Singh, Yuka Akama, Tomomi Ide, Keisuke Kida, Shouji Matsushima, Hidetaka Kaku, Nobuyuki Enzan, Masataka Ikeda, Takeshi Kitai, Tatsunori Taniguchi, Takahiro Okumura, Takeshi Tohyama, Hiroyuki Tsutsui, Yuya Matsue","doi":"10.1016/j.jacc.2025.09.1590","DOIUrl":"10.1016/j.jacc.2025.09.1590","url":null,"abstract":"<p><strong>Background: </strong>Frailty is prevalent in patients with heart failure and is associated with adverse outcomes. However, the extent to which the Clinical Frailty Scale (CFS) accurately captures physical and cognitive decline and its prognostic utility in contemporary heart failure care remain uncertain.</p><p><strong>Objectives: </strong>In this study, the authors sought to examine how well the CFS reflects domains of physical and cognitive function and its association with 2-year all-cause mortality in hospitalized patients with heart failure, using data from the Japanese Registry of Acute Decompensated Heart Failure-Next (JROADHF-NEXT).</p><p><strong>Methods: </strong>This study involved 3,905 patients from a prospective, nationwide, multicenter registry focusing on hospitalized patients with heart failure (JROADHF-NEXT). Patients were stratified into 6 categories (1-2, 3, 4, 5, 6, and 7-9) according to the CFS. Physical function was assessed using gait speed, the 5-chair stand test, the Short Physical Performance Battery (SPPB), grip strength, and 6-minute walk distance; cognitive function was measured using the Mini-Cog test. The primary outcome was 2-year all-cause mortality after discharge.</p><p><strong>Results: </strong>Physical function metrics and Mini-Cog scores progressively worsened with increasing CFS severity. Over a 2-year follow-up, 725 patients (18.6%) died, with mortality increasing stepwise with higher CFS scores. Adding CFS to the prognostic model significantly improved discrimination compared with a model based on the SPPB and Mini-Cog test.</p><p><strong>Conclusions: </strong>The CFS is an independent predictor of 2-year mortality and a robust integrative measure of physical and cognitive vulnerability in patients with heart failure. The CFS provides a practical screening tool that complements formal performance-based frailty assessments in contemporary heart failure management.</p>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":"20-32"},"PeriodicalIF":22.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145452053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06Epub Date: 2025-12-10DOI: 10.1016/j.jacc.2025.10.045
Zachariah S Demarais, Jeffrey E Olgin, James P Pirruccello
{"title":"Estimating Ascending Aortic Diameter From the Electrocardiogram.","authors":"Zachariah S Demarais, Jeffrey E Olgin, James P Pirruccello","doi":"10.1016/j.jacc.2025.10.045","DOIUrl":"10.1016/j.jacc.2025.10.045","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":"105-108"},"PeriodicalIF":22.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.jacc.2025.11.040
Peter Libby, Taylor Nordan, Nicholas Chiu, Ohad Oren, Marie Billaud, Aeron Small
{"title":"Wondering Y","authors":"Peter Libby, Taylor Nordan, Nicholas Chiu, Ohad Oren, Marie Billaud, Aeron Small","doi":"10.1016/j.jacc.2025.11.040","DOIUrl":"https://doi.org/10.1016/j.jacc.2025.11.040","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"40 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.jacc.2025.11.008
Perminder S. Sachdev, Adam C. Bentvelzen, Deborah Gustafson, Gurpreet K. Hansra, Satoshi Hosoki, Jiyang Jiang, Matthew J. Lennon, María Angeles Moro, Danit G. Saks, Katherine Samaras, Jason C. Kovacic, Rajesh Kalaria
{"title":"Vascular Cognitive Impairment and Dementia","authors":"Perminder S. Sachdev, Adam C. Bentvelzen, Deborah Gustafson, Gurpreet K. Hansra, Satoshi Hosoki, Jiyang Jiang, Matthew J. Lennon, María Angeles Moro, Danit G. Saks, Katherine Samaras, Jason C. Kovacic, Rajesh Kalaria","doi":"10.1016/j.jacc.2025.11.008","DOIUrl":"https://doi.org/10.1016/j.jacc.2025.11.008","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"51 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06Epub Date: 2025-10-15DOI: 10.1016/j.jacc.2025.09.1580
Nicholas M Pajewski, Kathryn E Callahan, Ariela R Orkaby
{"title":"Frailty and Intensive Blood Pressure Control in ESPRIT: Risk, Benefit, and the Persistent Question of Generalizability.","authors":"Nicholas M Pajewski, Kathryn E Callahan, Ariela R Orkaby","doi":"10.1016/j.jacc.2025.09.1580","DOIUrl":"10.1016/j.jacc.2025.09.1580","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":"17-19"},"PeriodicalIF":22.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06Epub Date: 2025-10-22DOI: 10.1016/j.jacc.2025.09.017
Christopher M Kramer, William A Van Decker
{"title":"A Time of Health Care Delivery Uncertainty: A Call for Member Engagement.","authors":"Christopher M Kramer, William A Van Decker","doi":"10.1016/j.jacc.2025.09.017","DOIUrl":"10.1016/j.jacc.2025.09.017","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":"112-114"},"PeriodicalIF":22.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145346029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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