Pub Date : 2026-03-13DOI: 10.1016/j.jacc.2025.11.016
Roger S. Blumenthal, Pamela B. Morris, Mario Gaudino, Heather M. Johnson, Timothy S. Anderson, Vera A. Bittner, Ron Blankstein, LaPrincess C. Brewer, Leslie Cho, Sarah D. de Ferranti, Eugenia Gianos, Ty J. Gluckman, Kristen F. Gradney, Ijeoma Isiadinso, Donald M. Lloyd-Jones, Joel C. Marrs, Seth S. Martin, Kellie H. McLain, Laxmi S. Mehta, Samia Mora, Wudeneh M. Mulugeta, Pradeep Natarajan, Ann Marie Navar, Carl E. Orringer, Tamar S. Polonsky, Harmony R. Reynolds, Joseph J. Saseen, Michael D. Shapiro, Daniel E. Soffer, Sheila A. Tynes, Chloé D. Villavaso, Salim S. Virani, John T. Wilkins
{"title":"2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia","authors":"Roger S. Blumenthal, Pamela B. Morris, Mario Gaudino, Heather M. Johnson, Timothy S. Anderson, Vera A. Bittner, Ron Blankstein, LaPrincess C. Brewer, Leslie Cho, Sarah D. de Ferranti, Eugenia Gianos, Ty J. Gluckman, Kristen F. Gradney, Ijeoma Isiadinso, Donald M. Lloyd-Jones, Joel C. Marrs, Seth S. Martin, Kellie H. McLain, Laxmi S. Mehta, Samia Mora, Wudeneh M. Mulugeta, Pradeep Natarajan, Ann Marie Navar, Carl E. Orringer, Tamar S. Polonsky, Harmony R. Reynolds, Joseph J. Saseen, Michael D. Shapiro, Daniel E. Soffer, Sheila A. Tynes, Chloé D. Villavaso, Salim S. Virani, John T. Wilkins","doi":"10.1016/j.jacc.2025.11.016","DOIUrl":"https://doi.org/10.1016/j.jacc.2025.11.016","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"94 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.jacc.2026.02.4869
Roger S. Blumenthal, Pamela B. Morris
{"title":"Clinical Guidelines as a Continuous Work in Progress: Moving at the Speed of Science","authors":"Roger S. Blumenthal, Pamela B. Morris","doi":"10.1016/j.jacc.2026.02.4869","DOIUrl":"https://doi.org/10.1016/j.jacc.2026.02.4869","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"325 1","pages":""},"PeriodicalIF":24.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147447245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1016/j.jacc.2026.01.066
Daniel A Gold, Nodari Maisuradze, Pratik B Sandesara, Nishant Vatsa, Matthew Gold, Adithya Yadalam, Scott Eisenberg, Brandon Davis, Yi-An Ko, Chang Liu, Nisreen Haroun, Ayman Alkhoder, Muhammad Owais, Wissam A Jaber, Paolo Raggi, William J Nicholson, Amit Shah, Kasra Moazzami, Viola Vaccarino, Arshed A Quyyumi
{"title":"The Comparative Prognostic Value of High Sensitivity Troponin Level and Stress Testing in Patients With Stable Coronary Artery Disease.","authors":"Daniel A Gold, Nodari Maisuradze, Pratik B Sandesara, Nishant Vatsa, Matthew Gold, Adithya Yadalam, Scott Eisenberg, Brandon Davis, Yi-An Ko, Chang Liu, Nisreen Haroun, Ayman Alkhoder, Muhammad Owais, Wissam A Jaber, Paolo Raggi, William J Nicholson, Amit Shah, Kasra Moazzami, Viola Vaccarino, Arshed A Quyyumi","doi":"10.1016/j.jacc.2026.01.066","DOIUrl":"https://doi.org/10.1016/j.jacc.2026.01.066","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":""},"PeriodicalIF":22.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-11DOI: 10.1016/j.jacc.2026.01.024
Muhammad Shahzeb Khan, Barry A Borlaug, Javed Butler, Mardi Gomberg-Maitland, Marc Humbert, Carolyn S P Lam, Yogesh N V Reddy, Gregg W Stone, Faiez Zannad, Ryan J Tedford
Pulmonary hypertension (PH) associated with left heart disease (LHD) is the most prevalent form of PH and is associated with substantial morbidity and mortality risk. Diagnosis is challenging because of overlapping phenotypes, imprecise echocardiographic estimates, and reliance on invasive hemodynamic assessment. Pulmonary arterial hypertension drugs have shown no benefit and may even be harmful in this population. There are no pharmacologic or interventional therapies approved specifically for PH-LHD to date, other than treatments directed at the underlying LHD. Multiple pharmacologic agents, such as sotatercept, relaxin analogues, and levosimendan, along with device-based strategies such as pulmonary artery denervation, transcatheter atrial shunts, and pericardiotomy, are under investigation. Progress in clinical trials has been hindered by patient recruitment, phenotypic heterogeneity, and a lack of standardized functional and hemodynamic outcomes. This review summarizes the current knowledge on PH-LHD, highlights emerging pharmacologic and invasive therapies, discusses barriers to trial design and regulatory approval, and proposes a framework to guide future investigations.
{"title":"Pulmonary Hypertension Associated With Left Heart Disease: Challenges, Emerging Strategies, and Future Directions.","authors":"Muhammad Shahzeb Khan, Barry A Borlaug, Javed Butler, Mardi Gomberg-Maitland, Marc Humbert, Carolyn S P Lam, Yogesh N V Reddy, Gregg W Stone, Faiez Zannad, Ryan J Tedford","doi":"10.1016/j.jacc.2026.01.024","DOIUrl":"https://doi.org/10.1016/j.jacc.2026.01.024","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) associated with left heart disease (LHD) is the most prevalent form of PH and is associated with substantial morbidity and mortality risk. Diagnosis is challenging because of overlapping phenotypes, imprecise echocardiographic estimates, and reliance on invasive hemodynamic assessment. Pulmonary arterial hypertension drugs have shown no benefit and may even be harmful in this population. There are no pharmacologic or interventional therapies approved specifically for PH-LHD to date, other than treatments directed at the underlying LHD. Multiple pharmacologic agents, such as sotatercept, relaxin analogues, and levosimendan, along with device-based strategies such as pulmonary artery denervation, transcatheter atrial shunts, and pericardiotomy, are under investigation. Progress in clinical trials has been hindered by patient recruitment, phenotypic heterogeneity, and a lack of standardized functional and hemodynamic outcomes. This review summarizes the current knowledge on PH-LHD, highlights emerging pharmacologic and invasive therapies, discusses barriers to trial design and regulatory approval, and proposes a framework to guide future investigations.</p>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":""},"PeriodicalIF":22.3,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1016/j.jacc.2025.12.044
Adith S Arun, Rishi M Shah, Yuan Lu, Sanket S Dhruva, Rishi K Wadhera, Harlan M Krumholz
{"title":"Exercise by Atherosclerotic Cardiovascular Disease Status: A JACC Data Report on Trends in the United States, 2020-2024.","authors":"Adith S Arun, Rishi M Shah, Yuan Lu, Sanket S Dhruva, Rishi K Wadhera, Harlan M Krumholz","doi":"10.1016/j.jacc.2025.12.044","DOIUrl":"https://doi.org/10.1016/j.jacc.2025.12.044","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"87 9","pages":"1149-1152"},"PeriodicalIF":22.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1016/j.jacc.2026.01.086
Omar Hahad, Sanjay Rajagopalan, Andreas Daiber, Sadeer Al-Kindi
{"title":"Hypertension as a Vulnerable Disease State Under Environmental Stress.","authors":"Omar Hahad, Sanjay Rajagopalan, Andreas Daiber, Sadeer Al-Kindi","doi":"10.1016/j.jacc.2026.01.086","DOIUrl":"https://doi.org/10.1016/j.jacc.2026.01.086","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":""},"PeriodicalIF":22.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1016/j.jacc.2025.12.051
Huanhuan Yang, Sanket S Dhruva, Rishi K Wadhera, Adith S Arun, Rishi M Shah, Harlan M Krumholz, Yuan Lu
{"title":"Dietary Quality by Sex, Age, and Race/Ethnicity: A JACC Data Report on Trends in the United States, 1999-2020.","authors":"Huanhuan Yang, Sanket S Dhruva, Rishi K Wadhera, Adith S Arun, Rishi M Shah, Harlan M Krumholz, Yuan Lu","doi":"10.1016/j.jacc.2025.12.051","DOIUrl":"https://doi.org/10.1016/j.jacc.2025.12.051","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"87 9","pages":"1161-1164"},"PeriodicalIF":22.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1016/j.jacc.2025.12.043
Adith S Arun, Rishi M Shah, Yuan Lu, Sanket S Dhruva, Harlan M Krumholz
{"title":"Sleep Duration by Atherosclerotic Cardiovascular Disease Status: A JACC Data Report on Trends in the United States, 2020-2024.","authors":"Adith S Arun, Rishi M Shah, Yuan Lu, Sanket S Dhruva, Harlan M Krumholz","doi":"10.1016/j.jacc.2025.12.043","DOIUrl":"https://doi.org/10.1016/j.jacc.2025.12.043","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"87 9","pages":"1153-1156"},"PeriodicalIF":22.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10DOI: 10.1016/j.jacc.2025.12.039
Smaraki Dash, ZhaoNian Zheng, Yunzhe Qian, Sanket S Dhruva, Yuan Lu, Lesley H Curtis, Rishi K Wadhera
{"title":"Out-of-Pocket Costs and Financial Burden Among Working-Age Adults With Cardiovascular Conditions: A JACC Data Report on Trends in the United States, 2007-2022.","authors":"Smaraki Dash, ZhaoNian Zheng, Yunzhe Qian, Sanket S Dhruva, Yuan Lu, Lesley H Curtis, Rishi K Wadhera","doi":"10.1016/j.jacc.2025.12.039","DOIUrl":"10.1016/j.jacc.2025.12.039","url":null,"abstract":"","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":"87 9","pages":"1135-1137"},"PeriodicalIF":22.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-10Epub Date: 2025-09-25DOI: 10.1016/j.jacc.2025.05.009
Dhruv S Kazi, Abdul R Abdullah, Suzanne V Arnold, Anirban Basu, Brandon K Bellows, Khadijah Breathett, Derek S Chew, David J Cohen, Colette DeJong, Paul A Heidenreich, Susan Hennessy, Inmaculada Hernandez, Nicolas Isaza, Karen E Joynt Maddox, Ann Marie Navar, Ankur Pandya, Kendra D Sims, Merilyn S Varghese, Liesl Zühlke
Aim: The "2025 AHA/ACC Statement on Cost/Value Methodology in Clinical Practice Guidelines (Update From 2014 Statement)" describes a systematic approach for consistent implementation of "economic value statements" across ACC/AHA guidelines. It updates the cost-effectiveness threshold and proposes a new level of certainty framework that summarizes the strength of the available evidence. Additionally, it describes how cost-effectiveness analyses (CEAs) can help advance equity in population cardiovascular health.
Methods: A focused literature search was conducted from January 9, 2024, to February 2, 2024, encompassing English-language publications related to CEA methodology in PubMed, EMBASE, and the Cochrane Library, with publication dates ranging from 1973 to the present. Additional relevant studies published during the writing process (through June 25, 2024) were also considered by the writing committee.
Structure: This Cost/Value Methodology Statement updates prior guidance regarding the incorporation of evidence from published CEAs into clinical guidelines. It provides guidance for identifying and synthesizing relevant high-quality evidence, developing economic value statements, and communicating level of certainty in such statements. It defines the US cost-effectiveness threshold as $120,000 per quality-adjusted life year gained, highlights special considerations related to cardiovascular drugs and devices, emphasizes health equity considerations when interpreting CEAs, and defines a reference case for future CEAs.
{"title":"2025 AHA/ACC Statement on Cost/Value Methodology in Clinical Practice Guidelines (Update From 2014 Statement): A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.","authors":"Dhruv S Kazi, Abdul R Abdullah, Suzanne V Arnold, Anirban Basu, Brandon K Bellows, Khadijah Breathett, Derek S Chew, David J Cohen, Colette DeJong, Paul A Heidenreich, Susan Hennessy, Inmaculada Hernandez, Nicolas Isaza, Karen E Joynt Maddox, Ann Marie Navar, Ankur Pandya, Kendra D Sims, Merilyn S Varghese, Liesl Zühlke","doi":"10.1016/j.jacc.2025.05.009","DOIUrl":"10.1016/j.jacc.2025.05.009","url":null,"abstract":"<p><strong>Aim: </strong>The \"2025 AHA/ACC Statement on Cost/Value Methodology in Clinical Practice Guidelines (Update From 2014 Statement)\" describes a systematic approach for consistent implementation of \"economic value statements\" across ACC/AHA guidelines. It updates the cost-effectiveness threshold and proposes a new level of certainty framework that summarizes the strength of the available evidence. Additionally, it describes how cost-effectiveness analyses (CEAs) can help advance equity in population cardiovascular health.</p><p><strong>Methods: </strong>A focused literature search was conducted from January 9, 2024, to February 2, 2024, encompassing English-language publications related to CEA methodology in PubMed, EMBASE, and the Cochrane Library, with publication dates ranging from 1973 to the present. Additional relevant studies published during the writing process (through June 25, 2024) were also considered by the writing committee.</p><p><strong>Structure: </strong>This Cost/Value Methodology Statement updates prior guidance regarding the incorporation of evidence from published CEAs into clinical guidelines. It provides guidance for identifying and synthesizing relevant high-quality evidence, developing economic value statements, and communicating level of certainty in such statements. It defines the US cost-effectiveness threshold as $120,000 per quality-adjusted life year gained, highlights special considerations related to cardiovascular drugs and devices, emphasizes health equity considerations when interpreting CEAs, and defines a reference case for future CEAs.</p>","PeriodicalId":17187,"journal":{"name":"Journal of the American College of Cardiology","volume":" ","pages":"1177-1206"},"PeriodicalIF":22.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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